-- dump date 20140619_154919 -- class Genbank::misc_feature -- table misc_feature_note -- id note 478434000001 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 478434000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 478434000003 Walker A motif; other site 478434000004 ATP binding site [chemical binding]; other site 478434000005 Walker B motif; other site 478434000006 arginine finger; other site 478434000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 478434000008 DnaA box-binding interface [nucleotide binding]; other site 478434000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 478434000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 478434000011 putative DNA binding surface [nucleotide binding]; other site 478434000012 dimer interface [polypeptide binding]; other site 478434000013 beta-clamp/clamp loader binding surface; other site 478434000014 beta-clamp/translesion DNA polymerase binding surface; other site 478434000015 recF protein; Region: recf; TIGR00611 478434000016 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 478434000017 Walker A/P-loop; other site 478434000018 ATP binding site [chemical binding]; other site 478434000019 Q-loop/lid; other site 478434000020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 478434000021 ABC transporter signature motif; other site 478434000022 Walker B; other site 478434000023 D-loop; other site 478434000024 H-loop/switch region; other site 478434000025 hypothetical protein; Provisional; Region: PRK03195 478434000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 478434000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 478434000028 Mg2+ binding site [ion binding]; other site 478434000029 G-X-G motif; other site 478434000030 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 478434000031 anchoring element; other site 478434000032 dimer interface [polypeptide binding]; other site 478434000033 ATP binding site [chemical binding]; other site 478434000034 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 478434000035 active site 478434000036 putative metal-binding site [ion binding]; other site 478434000037 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 478434000038 DNA gyrase subunit A; Validated; Region: PRK05560 478434000039 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 478434000040 CAP-like domain; other site 478434000041 active site 478434000042 primary dimer interface [polypeptide binding]; other site 478434000043 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 478434000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 478434000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 478434000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 478434000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 478434000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 478434000049 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 478434000050 Protein of unknown function (DUF2562); Region: DUF2562; pfam10814 478434000051 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 478434000052 active site 478434000053 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 478434000054 putative septation inhibitor protein; Reviewed; Region: PRK00159 478434000055 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 478434000056 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 478434000057 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 478434000058 Glutamine amidotransferase class-I; Region: GATase; pfam00117 478434000059 glutamine binding [chemical binding]; other site 478434000060 catalytic triad [active] 478434000061 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 478434000062 Catalytic domain of Protein Kinases; Region: PKc; cd00180 478434000063 active site 478434000064 ATP binding site [chemical binding]; other site 478434000065 substrate binding site [chemical binding]; other site 478434000066 activation loop (A-loop); other site 478434000067 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 478434000068 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 478434000069 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 478434000070 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 478434000071 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 478434000072 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 478434000073 Catalytic domain of Protein Kinases; Region: PKc; cd00180 478434000074 active site 478434000075 ATP binding site [chemical binding]; other site 478434000076 substrate binding site [chemical binding]; other site 478434000077 activation loop (A-loop); other site 478434000078 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 478434000079 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 478434000080 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 478434000081 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 478434000082 active site 478434000083 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 478434000084 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 478434000085 phosphopeptide binding site; other site 478434000086 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 478434000087 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 478434000088 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 478434000089 phosphopeptide binding site; other site 478434000090 Nitronate monooxygenase; Region: NMO; pfam03060 478434000091 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 478434000092 FMN binding site [chemical binding]; other site 478434000093 substrate binding site [chemical binding]; other site 478434000094 putative catalytic residue [active] 478434000095 Transcription factor WhiB; Region: Whib; pfam02467 478434000096 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 478434000097 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 478434000098 non-specific DNA binding site [nucleotide binding]; other site 478434000099 salt bridge; other site 478434000100 sequence-specific DNA binding site [nucleotide binding]; other site 478434000101 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 478434000102 NlpC/P60 family; Region: NLPC_P60; pfam00877 478434000103 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 478434000104 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 478434000105 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 478434000106 Protein of unknown function (DUF2694); Region: DUF2694; pfam10904 478434000107 Protein of unknown function (DUF2710); Region: DUF2710; pfam10921 478434000108 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 478434000109 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 478434000110 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 478434000111 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 478434000112 catalytic residue [active] 478434000113 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 478434000114 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 478434000115 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 478434000116 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 478434000117 acyl-activating enzyme (AAE) consensus motif; other site 478434000118 active site 478434000119 TIGR03084 family protein; Region: TIGR03084 478434000120 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 478434000121 Wyosine base formation; Region: Wyosine_form; pfam08608 478434000122 H+ Antiporter protein; Region: 2A0121; TIGR00900 478434000123 hypothetical protein; Validated; Region: PRK00228 478434000124 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 478434000125 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 478434000126 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 478434000127 active site 478434000128 HIGH motif; other site 478434000129 nucleotide binding site [chemical binding]; other site 478434000130 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 478434000131 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 478434000132 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 478434000133 active site 478434000134 KMSKS motif; other site 478434000135 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 478434000136 tRNA binding surface [nucleotide binding]; other site 478434000137 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 478434000138 MarR family; Region: MarR; pfam01047 478434000139 Transcriptional regulators [Transcription]; Region: FadR; COG2186 478434000140 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 478434000141 DNA-binding site [nucleotide binding]; DNA binding site 478434000142 probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856 478434000143 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 478434000144 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 478434000145 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 478434000146 inositol 1-phosphate synthase, Actinobacterial type; Region: mycothiol_INO1; TIGR03450 478434000147 Predicted transcriptional regulators [Transcription]; Region: COG1695 478434000148 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 478434000149 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 478434000150 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 478434000151 Transglycosylase; Region: Transgly; pfam00912 478434000152 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 478434000153 Predicted integral membrane protein [Function unknown]; Region: COG5650 478434000154 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 478434000155 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 478434000156 conserved cys residue [active] 478434000157 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 478434000158 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 478434000159 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 478434000160 dimer interface [polypeptide binding]; other site 478434000161 ssDNA binding site [nucleotide binding]; other site 478434000162 tetramer (dimer of dimers) interface [polypeptide binding]; other site 478434000163 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 478434000164 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 478434000165 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 478434000166 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 478434000167 replicative DNA helicase; Validated; Region: PRK07773 478434000168 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 478434000169 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 478434000170 Walker A motif; other site 478434000171 ATP binding site [chemical binding]; other site 478434000172 Walker B motif; other site 478434000173 DNA binding loops [nucleotide binding] 478434000174 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 478434000175 protein-splicing catalytic site; other site 478434000176 thioester formation/cholesterol transfer; other site 478434000177 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 478434000178 protein-splicing catalytic site; other site 478434000179 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 478434000180 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 478434000181 ADP-ribose binding site [chemical binding]; other site 478434000182 Predicted phosphatase homologous to the C-terminal domain of histone macroH2A1 [General function prediction only]; Region: COG2110 478434000183 Cellobiohydrolase A (1,4-beta-cellobiosidase A) [Carbohydrate transport and metabolism]; Region: CelA; COG5297 478434000184 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 478434000185 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 478434000186 FAD binding domain; Region: FAD_binding_4; pfam01565 478434000187 Berberine and berberine like; Region: BBE; pfam08031 478434000188 hypothetical protein; Provisional; Region: PRK12438 478434000189 hypothetical protein; Validated; Region: PRK00068 478434000190 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 478434000191 homotetrameric interface [polypeptide binding]; other site 478434000192 putative active site [active] 478434000193 metal binding site [ion binding]; metal-binding site 478434000194 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 478434000195 Monomeric isocitrate dehydrogenase; Region: IDH; pfam03971 478434000196 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 478434000197 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478434000198 short chain dehydrogenase; Provisional; Region: PRK06197 478434000199 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 478434000200 putative NAD(P) binding site [chemical binding]; other site 478434000201 active site 478434000202 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 478434000203 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 478434000204 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 478434000205 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 478434000206 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 478434000207 dimer interface [polypeptide binding]; other site 478434000208 active site 478434000209 glycine-pyridoxal phosphate binding site [chemical binding]; other site 478434000210 folate binding site [chemical binding]; other site 478434000211 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 478434000212 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 478434000213 putative NTP binding site [chemical binding]; other site 478434000214 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 478434000215 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 478434000216 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 478434000217 Walker A/P-loop; other site 478434000218 ATP binding site [chemical binding]; other site 478434000219 Q-loop/lid; other site 478434000220 ABC transporter signature motif; other site 478434000221 Walker B; other site 478434000222 D-loop; other site 478434000223 H-loop/switch region; other site 478434000224 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 478434000225 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 478434000226 ligand binding site [chemical binding]; other site 478434000227 flexible hinge region; other site 478434000228 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 478434000229 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 478434000230 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 478434000231 active site 478434000232 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 478434000233 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 478434000234 pyridoxal 5'-phosphate binding site [chemical binding]; other site 478434000235 homodimer interface [polypeptide binding]; other site 478434000236 catalytic residue [active] 478434000237 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 478434000238 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 478434000239 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478434000240 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 478434000241 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 478434000242 dimerization interface [polypeptide binding]; other site 478434000243 putative DNA binding site [nucleotide binding]; other site 478434000244 putative Zn2+ binding site [ion binding]; other site 478434000245 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 478434000246 hydrogenase 4 subunit B; Validated; Region: PRK06521 478434000247 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 478434000248 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 478434000249 NADH dehydrogenase; Region: NADHdh; cl00469 478434000250 Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; COG4237 478434000251 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 478434000252 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 478434000253 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 478434000254 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 478434000255 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 478434000256 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825 478434000257 putative hydrophobic ligand binding site [chemical binding]; other site 478434000258 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478434000259 S-adenosylmethionine binding site [chemical binding]; other site 478434000260 Predicted membrane protein [Function unknown]; Region: COG3305 478434000261 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 478434000262 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 478434000263 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 478434000264 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 478434000265 metal-binding site [ion binding] 478434000266 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 478434000267 Soluble P-type ATPase [General function prediction only]; Region: COG4087 478434000268 Predicted integral membrane protein [Function unknown]; Region: COG5660 478434000269 Putative zinc-finger; Region: zf-HC2; pfam13490 478434000270 Domain of unknown function (DUF222); Region: DUF222; pfam02720 478434000271 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 478434000272 active site 478434000273 Domain of unknown function (DUF222); Region: DUF222; pfam02720 478434000274 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478434000275 PPE family; Region: PPE; pfam00823 478434000276 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 478434000277 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 478434000278 FcoT-like thioesterase domain; Region: FcoT; pfam10862 478434000279 acyl-CoA synthetase; Validated; Region: PRK05857 478434000280 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 478434000281 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 478434000282 acyl-activating enzyme (AAE) consensus motif; other site 478434000283 acyl-activating enzyme (AAE) consensus motif; other site 478434000284 AMP binding site [chemical binding]; other site 478434000285 active site 478434000286 CoA binding site [chemical binding]; other site 478434000287 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 478434000288 AMP-binding enzyme; Region: AMP-binding; pfam00501 478434000289 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 478434000290 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 478434000291 acyl-activating enzyme (AAE) consensus motif; other site 478434000292 acyl-activating enzyme (AAE) consensus motif; other site 478434000293 active site 478434000294 AMP binding site [chemical binding]; other site 478434000295 CoA binding site [chemical binding]; other site 478434000296 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 478434000297 Condensation domain; Region: Condensation; pfam00668 478434000298 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 478434000299 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 478434000300 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 478434000301 acyl-activating enzyme (AAE) consensus motif; other site 478434000302 AMP binding site [chemical binding]; other site 478434000303 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 478434000304 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 478434000305 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 478434000306 putative NAD(P) binding site [chemical binding]; other site 478434000307 active site 478434000308 putative substrate binding site [chemical binding]; other site 478434000309 Predicted membrane protein [Function unknown]; Region: COG3336 478434000310 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 478434000311 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 478434000312 metal-binding site [ion binding] 478434000313 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 478434000314 Soluble P-type ATPase [General function prediction only]; Region: COG4087 478434000315 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 478434000316 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 478434000317 ligand binding site [chemical binding]; other site 478434000318 flexible hinge region; other site 478434000319 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 478434000320 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 478434000321 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 478434000322 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 478434000323 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 478434000324 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 478434000325 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 478434000326 motif II; other site 478434000327 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 478434000328 PE family; Region: PE; pfam00934 478434000329 B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction; Region: BBOX; cl00034 478434000330 Rhomboid family; Region: Rhomboid; pfam01694 478434000331 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 478434000332 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 478434000333 active site 478434000334 catalytic triad [active] 478434000335 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 478434000336 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 478434000337 NADP-binding site; other site 478434000338 homotetramer interface [polypeptide binding]; other site 478434000339 substrate binding site [chemical binding]; other site 478434000340 homodimer interface [polypeptide binding]; other site 478434000341 active site 478434000342 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 478434000343 dimer interface [polypeptide binding]; other site 478434000344 active site 478434000345 histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656 478434000346 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 478434000347 active site 478434000348 motif I; other site 478434000349 motif II; other site 478434000350 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 478434000351 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 478434000352 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 478434000353 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 478434000354 Transcriptional regulator [Transcription]; Region: LysR; COG0583 478434000355 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 478434000356 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 478434000357 dimerization interface [polypeptide binding]; other site 478434000358 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 478434000359 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 478434000360 PYR/PP interface [polypeptide binding]; other site 478434000361 dimer interface [polypeptide binding]; other site 478434000362 TPP binding site [chemical binding]; other site 478434000363 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 478434000364 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 478434000365 TPP-binding site; other site 478434000366 dimer interface [polypeptide binding]; other site 478434000367 acyl-CoA synthetase; Validated; Region: PRK05852 478434000368 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 478434000369 Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; Region: FACL_fum10p_like; cd05926 478434000370 acyl-activating enzyme (AAE) consensus motif; other site 478434000371 acyl-activating enzyme (AAE) consensus motif; other site 478434000372 putative AMP binding site [chemical binding]; other site 478434000373 putative active site [active] 478434000374 putative CoA binding site [chemical binding]; other site 478434000375 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 478434000376 elongation factor G; Reviewed; Region: PRK12740 478434000377 G1 box; other site 478434000378 putative GEF interaction site [polypeptide binding]; other site 478434000379 GTP/Mg2+ binding site [chemical binding]; other site 478434000380 Switch I region; other site 478434000381 G2 box; other site 478434000382 G3 box; other site 478434000383 Switch II region; other site 478434000384 G4 box; other site 478434000385 G5 box; other site 478434000386 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 478434000387 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 478434000388 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 478434000389 PPOX class probable F420-dependent enzyme, Rv0121 family; Region: Rv0121_F420; TIGR03668 478434000390 potential frameshift: common BLAST hit: gi|148821316|ref|YP_001286070.1| PE-PGRS family protein 478434000391 PE family; Region: PE; pfam00934 478434000392 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 478434000393 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 478434000394 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 478434000395 trehalose synthase; Region: treS_nterm; TIGR02456 478434000396 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 478434000397 active site 478434000398 catalytic site [active] 478434000399 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 478434000400 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 478434000401 Predicted membrane protein [Function unknown]; Region: COG3619 478434000402 Predicted esterase [General function prediction only]; Region: COG0627 478434000403 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 478434000404 putative active site [active] 478434000405 putative catalytic site [active] 478434000406 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 478434000407 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 478434000408 active site 478434000409 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 478434000410 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 478434000411 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 478434000412 Coenzyme A binding pocket [chemical binding]; other site 478434000413 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 478434000414 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 478434000415 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 478434000416 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478434000417 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 478434000418 Cytochrome P450; Region: p450; cl12078 478434000419 methionine sulfoxide reductase A; Provisional; Region: PRK14054 478434000420 SnoaL-like domain; Region: SnoaL_2; pfam12680 478434000421 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 478434000422 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 478434000423 NAD(P) binding site [chemical binding]; other site 478434000424 active site 478434000425 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 478434000426 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 478434000427 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 478434000428 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 478434000429 minor groove reading motif; other site 478434000430 helix-hairpin-helix signature motif; other site 478434000431 active site 478434000432 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 478434000433 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 478434000434 Cl- selectivity filter; other site 478434000435 Cl- binding residues [ion binding]; other site 478434000436 pore gating glutamate residue; other site 478434000437 dimer interface [polypeptide binding]; other site 478434000438 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 478434000439 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478434000440 Leucine carboxyl methyltransferase; Region: LCM; cl01306 478434000441 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 478434000442 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 478434000443 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 478434000444 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 478434000445 NAD(P) binding site [chemical binding]; other site 478434000446 catalytic residues [active] 478434000447 short chain dehydrogenase; Provisional; Region: PRK07791 478434000448 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 478434000449 NAD binding site [chemical binding]; other site 478434000450 homodimer interface [polypeptide binding]; other site 478434000451 active site 478434000452 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 478434000453 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 478434000454 NAD(P) binding site [chemical binding]; other site 478434000455 PE family; Region: PE; pfam00934 478434000456 PE-PPE domain; Region: PE-PPE; pfam08237 478434000457 PE-PPE domain; Region: PE-PPE; pfam08237 478434000458 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 478434000459 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 478434000460 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 478434000461 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 478434000462 Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155 478434000463 FAD binding site [chemical binding]; other site 478434000464 substrate binding site [chemical binding]; other site 478434000465 catalytic base [active] 478434000466 Protein of unknown function (DUF1348); Region: DUF1348; pfam07080 478434000467 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 478434000468 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 478434000469 ligand binding site [chemical binding]; other site 478434000470 homodimer interface [polypeptide binding]; other site 478434000471 NAD(P) binding site [chemical binding]; other site 478434000472 trimer interface B [polypeptide binding]; other site 478434000473 trimer interface A [polypeptide binding]; other site 478434000474 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 478434000475 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 478434000476 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 478434000477 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 478434000478 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 478434000479 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478434000480 QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360 478434000481 PE family; Region: PE; pfam00934 478434000482 PE-PPE domain; Region: PE-PPE; pfam08237 478434000483 PE family; Region: PE; pfam00934 478434000484 PE-PPE domain; Region: PE-PPE; pfam08237 478434000485 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 478434000486 FAD binding domain; Region: FAD_binding_4; pfam01565 478434000487 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 478434000488 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 478434000489 NAD(P) binding site [chemical binding]; other site 478434000490 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 478434000491 active site 478434000492 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 478434000493 putative hydrophobic ligand binding site [chemical binding]; other site 478434000494 Transcriptional regulators [Transcription]; Region: GntR; COG1802 478434000495 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 478434000496 DNA-binding site [nucleotide binding]; DNA binding site 478434000497 FCD domain; Region: FCD; pfam07729 478434000498 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07786 478434000499 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 478434000500 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 478434000501 acyl-activating enzyme (AAE) consensus motif; other site 478434000502 acyl-activating enzyme (AAE) consensus motif; other site 478434000503 putative AMP binding site [chemical binding]; other site 478434000504 putative active site [active] 478434000505 putative CoA binding site [chemical binding]; other site 478434000506 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 478434000507 Permease; Region: Permease; pfam02405 478434000508 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 478434000509 Permease; Region: Permease; pfam02405 478434000510 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 478434000511 mce related protein; Region: MCE; pfam02470 478434000512 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 478434000513 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 478434000514 mce related protein; Region: MCE; pfam02470 478434000515 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 478434000516 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 478434000517 mce related protein; Region: MCE; pfam02470 478434000518 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 478434000519 mce related protein; Region: MCE; pfam02470 478434000520 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 478434000521 mce related protein; Region: MCE; pfam02470 478434000522 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 478434000523 mce related protein; Region: MCE; pfam02470 478434000524 RDD family; Region: RDD; pfam06271 478434000525 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 478434000526 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 478434000527 Predicted membrane protein [Function unknown]; Region: COG1511 478434000528 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 478434000529 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 478434000530 Pirin-related protein [General function prediction only]; Region: COG1741 478434000531 Pirin; Region: Pirin; pfam02678 478434000532 RNA polymerase factor sigma-70; Validated; Region: PRK08241 478434000533 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 478434000534 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 478434000535 DNA binding residues [nucleotide binding] 478434000536 SnoaL-like domain; Region: SnoaL_2; pfam12680 478434000537 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 478434000538 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 478434000539 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 478434000540 putative metallohydrolase, TIGR04338 family; Region: HEXXH_Rv0185 478434000541 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 478434000542 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 478434000543 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 478434000544 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 478434000545 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 478434000546 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478434000547 S-adenosylmethionine binding site [chemical binding]; other site 478434000548 SPW repeat; Region: SPW; pfam03779 478434000549 SPW repeat; Region: SPW; pfam03779 478434000550 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 478434000551 6-phosphogluconate dehydratase; Region: edd; TIGR01196 478434000552 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 478434000553 putative homodimer interface [polypeptide binding]; other site 478434000554 putative homotetramer interface [polypeptide binding]; other site 478434000555 putative allosteric switch controlling residues; other site 478434000556 putative metal binding site [ion binding]; other site 478434000557 putative homodimer-homodimer interface [polypeptide binding]; other site 478434000558 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 478434000559 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 478434000560 putative substrate translocation pore; other site 478434000561 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 478434000562 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 478434000563 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 478434000564 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 478434000565 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 478434000566 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 478434000567 Walker A/P-loop; other site 478434000568 ATP binding site [chemical binding]; other site 478434000569 Q-loop/lid; other site 478434000570 ABC transporter signature motif; other site 478434000571 Walker B; other site 478434000572 D-loop; other site 478434000573 H-loop/switch region; other site 478434000574 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 478434000575 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 478434000576 Walker A/P-loop; other site 478434000577 ATP binding site [chemical binding]; other site 478434000578 Q-loop/lid; other site 478434000579 ABC transporter signature motif; other site 478434000580 Walker B; other site 478434000581 D-loop; other site 478434000582 H-loop/switch region; other site 478434000583 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 478434000584 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 478434000585 dimerization interface [polypeptide binding]; other site 478434000586 DNA binding residues [nucleotide binding] 478434000587 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 478434000588 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478434000589 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 478434000590 The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762 478434000591 putative [Fe4-S4] binding site [ion binding]; other site 478434000592 putative molybdopterin cofactor binding site [chemical binding]; other site 478434000593 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 478434000594 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 478434000595 putative molybdopterin cofactor binding site; other site 478434000596 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 478434000597 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 478434000598 active site 478434000599 Zn binding site [ion binding]; other site 478434000600 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 478434000601 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 478434000602 Predicted integral membrane protein [Function unknown]; Region: COG0392 478434000603 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 478434000604 Domain of unknown function DUF20; Region: UPF0118; pfam01594 478434000605 MMPL family; Region: MMPL; pfam03176 478434000606 MMPL family; Region: MMPL; pfam03176 478434000607 LabA_like proteins; Region: LabA_like; cd06167 478434000608 putative metal binding site [ion binding]; other site 478434000609 Putative methyltransferase; Region: Methyltransf_4; pfam02390 478434000610 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 478434000611 active site 478434000612 substrate-binding site [chemical binding]; other site 478434000613 metal-binding site [ion binding] 478434000614 GTP binding site [chemical binding]; other site 478434000615 nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526 478434000616 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 478434000617 active site 478434000618 (T/H)XGH motif; other site 478434000619 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 478434000620 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 478434000621 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 478434000622 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 478434000623 FeS/SAM binding site; other site 478434000624 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 478434000625 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 478434000626 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 478434000627 acyl-activating enzyme (AAE) consensus motif; other site 478434000628 acyl-activating enzyme (AAE) consensus motif; other site 478434000629 putative AMP binding site [chemical binding]; other site 478434000630 putative active site [active] 478434000631 putative CoA binding site [chemical binding]; other site 478434000632 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 478434000633 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 478434000634 active site 478434000635 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 478434000636 putative active site [active] 478434000637 putative catalytic site [active] 478434000638 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 478434000639 active site 2 [active] 478434000640 active site 1 [active] 478434000641 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 478434000642 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 478434000643 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 478434000644 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cd00321 478434000645 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 478434000646 Moco binding site; other site 478434000647 metal coordination site [ion binding]; other site 478434000648 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 478434000649 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 478434000650 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 478434000651 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 478434000652 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 478434000653 enoyl-CoA hydratase; Provisional; Region: PRK08252 478434000654 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 478434000655 substrate binding site [chemical binding]; other site 478434000656 oxyanion hole (OAH) forming residues; other site 478434000657 trimer interface [polypeptide binding]; other site 478434000658 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 478434000659 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 478434000660 NAD binding site [chemical binding]; other site 478434000661 catalytic residues [active] 478434000662 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478434000663 S-adenosylmethionine binding site [chemical binding]; other site 478434000664 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 478434000665 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 478434000666 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 478434000667 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 478434000668 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 478434000669 putative active site [active] 478434000670 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 478434000671 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 478434000672 active site 478434000673 substrate binding pocket [chemical binding]; other site 478434000674 homodimer interaction site [polypeptide binding]; other site 478434000675 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 478434000676 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 478434000677 active site 478434000678 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 478434000679 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478434000680 Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain; Region: RNRR2_Rv0233_like; cd07911 478434000681 active site 478434000682 diiron metal binding site [ion binding]; other site 478434000683 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 478434000684 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 478434000685 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 478434000686 NAD(P) binding site [chemical binding]; other site 478434000687 catalytic residues [active] 478434000688 Lipase maturation factor; Region: LMF1; pfam06762 478434000689 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 478434000690 Protein of unknown function (DUF2613); Region: DUF2613; pfam11021 478434000691 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 478434000692 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 478434000693 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 478434000694 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478434000695 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 478434000696 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 478434000697 MaoC like domain; Region: MaoC_dehydratas; pfam01575 478434000698 active site 2 [active] 478434000699 active site 1 [active] 478434000700 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 478434000701 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 478434000702 NAD(P) binding site [chemical binding]; other site 478434000703 active site 478434000704 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 478434000705 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 478434000706 dimer interface [polypeptide binding]; other site 478434000707 active site 478434000708 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 478434000709 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 478434000710 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 478434000711 FAD binding site [chemical binding]; other site 478434000712 substrate binding site [chemical binding]; other site 478434000713 catalytic residues [active] 478434000714 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 478434000715 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 478434000716 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386 478434000717 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 478434000718 catalytic loop [active] 478434000719 iron binding site [ion binding]; other site 478434000720 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803 478434000721 L-aspartate oxidase; Provisional; Region: PRK06175 478434000722 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 478434000723 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 478434000724 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 478434000725 putative dimer interface [polypeptide binding]; other site 478434000726 nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374 478434000727 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 478434000728 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 478434000729 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 478434000730 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 478434000731 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 478434000732 homotrimer interface [polypeptide binding]; other site 478434000733 Walker A motif; other site 478434000734 GTP binding site [chemical binding]; other site 478434000735 Walker B motif; other site 478434000736 cobyric acid synthase; Provisional; Region: PRK00784 478434000737 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 478434000738 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 478434000739 catalytic triad [active] 478434000740 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478434000741 PPE family; Region: PPE; pfam00823 478434000742 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 478434000743 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 478434000744 putative active site [active] 478434000745 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 478434000746 putative active site [active] 478434000747 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 478434000748 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 478434000749 active site 478434000750 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 478434000751 DNA binding site [nucleotide binding] 478434000752 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 478434000753 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 478434000754 Coenzyme A binding pocket [chemical binding]; other site 478434000755 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 478434000756 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 478434000757 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 478434000758 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 478434000759 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 478434000760 intersubunit interface [polypeptide binding]; other site 478434000761 5-oxoprolinase; Region: PLN02666 478434000762 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 478434000763 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 478434000764 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 478434000765 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 478434000766 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 478434000767 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 478434000768 nucleotide binding site [chemical binding]; other site 478434000769 acyl-CoA synthetase; Validated; Region: PRK07788 478434000770 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 478434000771 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 478434000772 active site 478434000773 CoA binding site [chemical binding]; other site 478434000774 AMP binding site [chemical binding]; other site 478434000775 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 478434000776 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 478434000777 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 478434000778 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 478434000779 FAD binding site [chemical binding]; other site 478434000780 substrate binding site [chemical binding]; other site 478434000781 catalytic base [active] 478434000782 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 478434000783 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 478434000784 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478434000785 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 478434000786 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 478434000787 Zn binding site [ion binding]; other site 478434000788 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 478434000789 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 478434000790 putative active site [active] 478434000791 PE family; Region: PE; pfam00934 478434000792 PE family; Region: PE; pfam00934 478434000793 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478434000794 PPE family; Region: PPE; pfam00823 478434000795 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478434000796 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 478434000797 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 478434000798 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 478434000799 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 478434000800 Walker A motif; other site 478434000801 ATP binding site [chemical binding]; other site 478434000802 Walker B motif; other site 478434000803 arginine finger; other site 478434000804 Protein of unknown function (DUF690); Region: DUF690; pfam05108 478434000805 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 478434000806 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 478434000807 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 478434000808 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 478434000809 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 478434000810 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478434000811 PPE family; Region: PPE; pfam00823 478434000812 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 478434000813 EspG family; Region: ESX-1_EspG; pfam14011 478434000814 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 478434000815 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 478434000816 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 478434000817 active site 478434000818 catalytic residues [active] 478434000819 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 478434000820 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 478434000821 Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752 478434000822 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 478434000823 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478434000824 S-adenosylmethionine binding site [chemical binding]; other site 478434000825 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4424 478434000826 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 478434000827 Sulfatase; Region: Sulfatase; cl17466 478434000828 hypothetical protein; Region: PHA01748 478434000829 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 478434000830 putative active site [active] 478434000831 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 478434000832 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478434000833 light-dependent protochlorophyllide reductase (LPOR)-like, classical (c)-like SDRs; Region: LPOR_like_SDR_c_like; cd09810 478434000834 protochlorophyllide reductase; Region: PLN00015 478434000835 putative NAD(P) binding site [chemical binding]; other site 478434000836 active site 478434000837 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478434000838 PPE family; Region: PPE; pfam00823 478434000839 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478434000840 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478434000841 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478434000842 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478434000843 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478434000844 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478434000845 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478434000846 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478434000847 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478434000848 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478434000849 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478434000850 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478434000851 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 478434000852 putative FMN binding site [chemical binding]; other site 478434000853 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 478434000854 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 478434000855 active site 478434000856 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 478434000857 SnoaL-like domain; Region: SnoaL_4; pfam13577 478434000858 SnoaL-like domain; Region: SnoaL_3; pfam13474 478434000859 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 478434000860 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 478434000861 nucleotide binding site [chemical binding]; other site 478434000862 Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones]; Region: HtpG; COG0326 478434000863 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 478434000864 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 478434000865 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 478434000866 active site 478434000867 catalytic residues [active] 478434000868 Muconolactone delta-isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CatC1; COG4829 478434000869 Muconolactone delta-isomerase; Region: MIase; cl01992 478434000870 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 478434000871 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 478434000872 putative active site [active] 478434000873 catalytic site [active] 478434000874 putative metal binding site [ion binding]; other site 478434000875 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 478434000876 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 478434000877 putative substrate binding pocket [chemical binding]; other site 478434000878 AC domain interface; other site 478434000879 catalytic triad [active] 478434000880 AB domain interface; other site 478434000881 interchain disulfide; other site 478434000882 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 478434000883 trimer interface [polypeptide binding]; other site 478434000884 active site 478434000885 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 478434000886 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 478434000887 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 478434000888 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 478434000889 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 478434000890 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 478434000891 dimerization interface [polypeptide binding]; other site 478434000892 putative DNA binding site [nucleotide binding]; other site 478434000893 putative Zn2+ binding site [ion binding]; other site 478434000894 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 478434000895 active site residue [active] 478434000896 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478434000897 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 478434000898 Cytochrome P450; Region: p450; cl12078 478434000899 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 478434000900 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478434000901 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 478434000902 Methyltransferase domain; Region: Methyltransf_23; pfam13489 478434000903 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478434000904 S-adenosylmethionine binding site [chemical binding]; other site 478434000905 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 478434000906 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478434000907 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 478434000908 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 478434000909 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 478434000910 SnoaL-like domain; Region: SnoaL_2; pfam12680 478434000911 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 478434000912 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 478434000913 substrate binding site; other site 478434000914 tetramer interface; other site 478434000915 PE family; Region: PE; pfam00934 478434000916 Domain of unknown function (DUF222); Region: DUF222; pfam02720 478434000917 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 478434000918 active site 478434000919 aminotransferase AlaT; Validated; Region: PRK09265 478434000920 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 478434000921 pyridoxal 5'-phosphate binding site [chemical binding]; other site 478434000922 homodimer interface [polypeptide binding]; other site 478434000923 catalytic residue [active] 478434000924 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 478434000925 4Fe-4S binding domain; Region: Fer4; pfam00037 478434000926 Cysteine-rich domain; Region: CCG; pfam02754 478434000927 Cysteine-rich domain; Region: CCG; pfam02754 478434000928 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 478434000929 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 478434000930 DNA binding residues [nucleotide binding] 478434000931 dimerization interface [polypeptide binding]; other site 478434000932 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 478434000933 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 478434000934 G1 box; other site 478434000935 GTP/Mg2+ binding site [chemical binding]; other site 478434000936 G2 box; other site 478434000937 Switch I region; other site 478434000938 G3 box; other site 478434000939 Switch II region; other site 478434000940 G4 box; other site 478434000941 G5 box; other site 478434000942 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 478434000943 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 478434000944 G1 box; other site 478434000945 GTP/Mg2+ binding site [chemical binding]; other site 478434000946 G2 box; other site 478434000947 Switch I region; other site 478434000948 G3 box; other site 478434000949 Switch II region; other site 478434000950 Uncharacterized MobA-related protein [General function prediction only]; Region: COG2068 478434000951 active site 478434000952 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 478434000953 TIGR04255 family protein; Region: sporadTIGR04255 478434000954 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 478434000955 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 478434000956 nucleotide binding site [chemical binding]; other site 478434000957 NEF interaction site [polypeptide binding]; other site 478434000958 SBD interface [polypeptide binding]; other site 478434000959 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 478434000960 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 478434000961 dimer interface [polypeptide binding]; other site 478434000962 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 478434000963 chaperone protein DnaJ; Provisional; Region: PRK14279 478434000964 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 478434000965 HSP70 interaction site [polypeptide binding]; other site 478434000966 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 478434000967 Zn binding sites [ion binding]; other site 478434000968 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 478434000969 dimer interface [polypeptide binding]; other site 478434000970 Helix-Turn-Helix DNA binding domain of HspR-like transcription regulators; Region: HTH_HspR-like; cd01279 478434000971 DNA binding residues [nucleotide binding] 478434000972 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 478434000973 putative dimer interface [polypeptide binding]; other site 478434000974 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478434000975 PPE family; Region: PPE; pfam00823 478434000976 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478434000977 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478434000978 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478434000979 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478434000980 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 478434000981 CoenzymeA binding site [chemical binding]; other site 478434000982 subunit interaction site [polypeptide binding]; other site 478434000983 PHB binding site; other site 478434000984 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 478434000985 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 478434000986 GDP-binding site [chemical binding]; other site 478434000987 ACT binding site; other site 478434000988 IMP binding site; other site 478434000989 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 478434000990 Peptidase family M50; Region: Peptidase_M50; pfam02163 478434000991 active site 478434000992 putative substrate binding region [chemical binding]; other site 478434000993 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 478434000994 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 478434000995 MgtE intracellular N domain; Region: MgtE_N; pfam03448 478434000996 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 478434000997 Divalent cation transporter; Region: MgtE; pfam01769 478434000998 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 478434000999 fructose-bisphosphate aldolase, class II, yeast/E. coli subtype; Region: FruBisAldo_II_A; TIGR01520 478434001000 active site 478434001001 intersubunit interface [polypeptide binding]; other site 478434001002 zinc binding site [ion binding]; other site 478434001003 Na+ binding site [ion binding]; other site 478434001004 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 478434001005 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 478434001006 Predicted glycosyl hydrolase [Carbohydrate transport and metabolism]; Region: COG4833 478434001007 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 478434001008 AAA domain; Region: AAA_33; pfam13671 478434001009 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 478434001010 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 478434001011 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 478434001012 putative hydrophobic ligand binding site [chemical binding]; other site 478434001013 MoxR-like ATPases [General function prediction only]; Region: COG0714 478434001014 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 478434001015 Ligand binding site; other site 478434001016 metal-binding site 478434001017 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 478434001018 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 478434001019 XdhC Rossmann domain; Region: XdhC_C; pfam13478 478434001020 carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416 478434001021 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 478434001022 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 478434001023 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 478434001024 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 478434001025 catalytic loop [active] 478434001026 iron binding site [ion binding]; other site 478434001027 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 478434001028 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 478434001029 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 478434001030 Uncharacterized conserved protein [Function unknown]; Region: COG3360 478434001031 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 478434001032 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 478434001033 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 478434001034 active site 478434001035 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 478434001036 Clp amino terminal domain; Region: Clp_N; pfam02861 478434001037 Clp amino terminal domain; Region: Clp_N; pfam02861 478434001038 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 478434001039 Walker A motif; other site 478434001040 ATP binding site [chemical binding]; other site 478434001041 Walker B motif; other site 478434001042 arginine finger; other site 478434001043 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 478434001044 Walker A motif; other site 478434001045 ATP binding site [chemical binding]; other site 478434001046 Walker B motif; other site 478434001047 arginine finger; other site 478434001048 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 478434001049 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 478434001050 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 478434001051 heme-binding site [chemical binding]; other site 478434001052 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 478434001053 FAD binding pocket [chemical binding]; other site 478434001054 FAD binding motif [chemical binding]; other site 478434001055 phosphate binding motif [ion binding]; other site 478434001056 beta-alpha-beta structure motif; other site 478434001057 NAD binding pocket [chemical binding]; other site 478434001058 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 478434001059 cyclase homology domain; Region: CHD; cd07302 478434001060 nucleotidyl binding site; other site 478434001061 metal binding site [ion binding]; metal-binding site 478434001062 dimer interface [polypeptide binding]; other site 478434001063 Predicted ATPase [General function prediction only]; Region: COG3903 478434001064 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 478434001065 Walker A motif; other site 478434001066 ATP binding site [chemical binding]; other site 478434001067 Walker B motif; other site 478434001068 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 478434001069 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 478434001070 DNA binding residues [nucleotide binding] 478434001071 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478434001072 PPE family; Region: PPE; pfam00823 478434001073 Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase) [Nucleotide transport and metabolism]; Region: PurT; COG0027 478434001074 ATP-grasp domain; Region: ATP-grasp_4; cl17255 478434001075 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 478434001076 active site residue [active] 478434001077 O-succinylhomoserine sulfhydrylase; Provisional; Region: PRK07810 478434001078 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 478434001079 homodimer interface [polypeptide binding]; other site 478434001080 substrate-cofactor binding pocket; other site 478434001081 pyridoxal 5'-phosphate binding site [chemical binding]; other site 478434001082 catalytic residue [active] 478434001083 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 478434001084 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 478434001085 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 478434001086 Domain of unknown function (DUF222); Region: DUF222; pfam02720 478434001087 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 478434001088 active site 478434001089 PLD-like domain; Region: PLDc_2; pfam13091 478434001090 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 478434001091 Beta-lactamase; Region: Beta-lactamase; pfam00144 478434001092 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 478434001093 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 478434001094 FAD binding site [chemical binding]; other site 478434001095 substrate binding pocket [chemical binding]; other site 478434001096 catalytic base [active] 478434001097 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 478434001098 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 478434001099 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 478434001100 acyl-CoA synthetase; Validated; Region: PRK05850 478434001101 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 478434001102 acyl-activating enzyme (AAE) consensus motif; other site 478434001103 active site 478434001104 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 478434001105 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 478434001106 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 478434001107 active site 478434001108 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 478434001109 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 478434001110 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 478434001111 Thioesterase; Region: PKS_TE; smart00824 478434001112 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 478434001113 glucose-6-phosphate dehydrogenase (coenzyme-F420); Region: F420_G6P_DH; TIGR03554 478434001114 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 478434001115 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 478434001116 phosphate acetyltransferase; Reviewed; Region: PRK05632 478434001117 DRTGG domain; Region: DRTGG; pfam07085 478434001118 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 478434001119 propionate/acetate kinase; Provisional; Region: PRK12379 478434001120 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 478434001121 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 478434001122 Catalytic domain of Protein Kinases; Region: PKc; cd00180 478434001123 active site 478434001124 ATP binding site [chemical binding]; other site 478434001125 substrate binding site [chemical binding]; other site 478434001126 activation loop (A-loop); other site 478434001127 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 478434001128 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 478434001129 substrate binding pocket [chemical binding]; other site 478434001130 membrane-bound complex binding site; other site 478434001131 hinge residues; other site 478434001132 NUDIX domain; Region: NUDIX; pfam00293 478434001133 nudix motif; other site 478434001134 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 478434001135 thiamine phosphate binding site [chemical binding]; other site 478434001136 active site 478434001137 pyrophosphate binding site [ion binding]; other site 478434001138 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 478434001139 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 478434001140 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 478434001141 thiS-thiF/thiG interaction site; other site 478434001142 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 478434001143 ThiS interaction site; other site 478434001144 putative active site [active] 478434001145 tetramer interface [polypeptide binding]; other site 478434001146 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 478434001147 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 478434001148 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 478434001149 PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH. Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816 478434001150 PA/protease or protease-like domain interface [polypeptide binding]; other site 478434001151 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 478434001152 active site 478434001153 metal binding site [ion binding]; metal-binding site 478434001154 Predicted metalloprotease [General function prediction only]; Region: COG2321 478434001155 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 478434001156 Zn binding site [ion binding]; other site 478434001157 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 478434001158 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 478434001159 dimer interface [polypeptide binding]; other site 478434001160 substrate binding site [chemical binding]; other site 478434001161 ATP binding site [chemical binding]; other site 478434001162 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 478434001163 ThiC-associated domain; Region: ThiC-associated; pfam13667 478434001164 ThiC family; Region: ThiC; pfam01964 478434001165 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 478434001166 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 478434001167 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 478434001168 motif II; other site 478434001169 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 478434001170 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 478434001171 putative catalytic site [active] 478434001172 putative phosphate binding site [ion binding]; other site 478434001173 active site 478434001174 metal binding site A [ion binding]; metal-binding site 478434001175 DNA binding site [nucleotide binding] 478434001176 putative AP binding site [nucleotide binding]; other site 478434001177 putative metal binding site B [ion binding]; other site 478434001178 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 478434001179 active site 478434001180 catalytic residues [active] 478434001181 metal binding site [ion binding]; metal-binding site 478434001182 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 478434001183 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 478434001184 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 478434001185 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 478434001186 E-class dimer interface [polypeptide binding]; other site 478434001187 P-class dimer interface [polypeptide binding]; other site 478434001188 active site 478434001189 Cu2+ binding site [ion binding]; other site 478434001190 Zn2+ binding site [ion binding]; other site 478434001191 carboxylate-amine ligase; Provisional; Region: PRK13517 478434001192 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 478434001193 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 478434001194 AAA family ATPase, CDC48 subfamily; Region: CDC48; TIGR01243 478434001195 Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359 478434001196 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 478434001197 Walker A motif; other site 478434001198 ATP binding site [chemical binding]; other site 478434001199 Walker B motif; other site 478434001200 arginine finger; other site 478434001201 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 478434001202 Walker A motif; other site 478434001203 ATP binding site [chemical binding]; other site 478434001204 Walker B motif; other site 478434001205 arginine finger; other site 478434001206 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 478434001207 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 478434001208 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 478434001209 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 478434001210 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 478434001211 dimer interface [polypeptide binding]; other site 478434001212 putative functional site; other site 478434001213 putative MPT binding site; other site 478434001214 short chain dehydrogenase; Provisional; Region: PRK06197 478434001215 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 478434001216 putative NAD(P) binding site [chemical binding]; other site 478434001217 active site 478434001218 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 478434001219 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 478434001220 ring oligomerisation interface [polypeptide binding]; other site 478434001221 ATP/Mg binding site [chemical binding]; other site 478434001222 stacking interactions; other site 478434001223 hinge regions; other site 478434001224 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478434001225 PPE family; Region: PPE; pfam00823 478434001226 Protein of unknown function (DUF664); Region: DUF664; pfam04978 478434001227 DinB superfamily; Region: DinB_2; pfam12867 478434001228 putative anti-sigmaE protein; Provisional; Region: PRK13920 478434001229 Anti-sigma-K factor rskA; Region: RskA; pfam10099 478434001230 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 478434001231 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 478434001232 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 478434001233 DNA binding residues [nucleotide binding] 478434001234 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 478434001235 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 478434001236 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 478434001237 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478434001238 S-adenosylmethionine binding site [chemical binding]; other site 478434001239 Uncharacterized conserved protein [Function unknown]; Region: COG3496 478434001240 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 478434001241 Subunit A of Class III extradiol dioxygenases; Region: Extradiol_Dioxygenase_3A_like; cl06673 478434001242 dimer interface [polypeptide binding]; other site 478434001243 Transport protein; Region: actII; TIGR00833 478434001244 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 478434001245 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 478434001246 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478434001247 PPE family; Region: PPE; pfam00823 478434001248 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478434001249 Protein of unknown function (DUF2782); Region: DUF2782; pfam11191 478434001250 enoyl-CoA hydratase; Provisional; Region: PRK12478 478434001251 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 478434001252 substrate binding site [chemical binding]; other site 478434001253 oxyanion hole (OAH) forming residues; other site 478434001254 trimer interface [polypeptide binding]; other site 478434001255 PemK-like protein; Region: PemK; pfam02452 478434001256 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 478434001257 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 478434001258 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 478434001259 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 478434001260 NAD(P) binding site [chemical binding]; other site 478434001261 catalytic residues [active] 478434001262 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3564 478434001263 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 478434001264 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 478434001265 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 478434001266 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 478434001267 Uncharacterized conserved protein [Function unknown]; Region: COG2128 478434001268 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 478434001269 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 478434001270 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 478434001271 non-specific DNA binding site [nucleotide binding]; other site 478434001272 salt bridge; other site 478434001273 sequence-specific DNA binding site [nucleotide binding]; other site 478434001274 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 478434001275 Domain of unknown function (DUF955); Region: DUF955; pfam06114 478434001276 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 478434001277 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 478434001278 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 478434001279 active site 478434001280 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 478434001281 active site 2 [active] 478434001282 isocitrate lyase; Provisional; Region: PRK15063 478434001283 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cd06556 478434001284 oligomerization interface [polypeptide binding]; other site 478434001285 active site 478434001286 metal binding site [ion binding]; metal-binding site 478434001287 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 478434001288 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 478434001289 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 478434001290 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 478434001291 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478434001292 S-adenosylmethionine binding site [chemical binding]; other site 478434001293 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 478434001294 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 478434001295 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478434001296 S-adenosylmethionine binding site [chemical binding]; other site 478434001297 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224 478434001298 UbiA prenyltransferase family; Region: UbiA; pfam01040 478434001299 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 478434001300 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478434001301 Predicted membrane protein [Function unknown]; Region: COG2733 478434001302 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 478434001303 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 478434001304 non-specific DNA binding site [nucleotide binding]; other site 478434001305 salt bridge; other site 478434001306 sequence-specific DNA binding site [nucleotide binding]; other site 478434001307 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 478434001308 Protein of unknown function (DUF2599); Region: DUF2599; pfam10783 478434001309 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 478434001310 intersubunit interface [polypeptide binding]; other site 478434001311 active site 478434001312 catalytic residue [active] 478434001313 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 478434001314 Predicted amidohydrolase [General function prediction only]; Region: COG0388 478434001315 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 478434001316 putative active site [active] 478434001317 catalytic triad [active] 478434001318 putative dimer interface [polypeptide binding]; other site 478434001319 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 478434001320 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 478434001321 FAD binding domain; Region: FAD_binding_4; pfam01565 478434001322 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 478434001323 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 478434001324 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 478434001325 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 478434001326 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 478434001327 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 478434001328 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 478434001329 NAD(P) binding site [chemical binding]; other site 478434001330 active site 478434001331 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 478434001332 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 478434001333 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 478434001334 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 478434001335 putative ADP-binding pocket [chemical binding]; other site 478434001336 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 478434001337 L-lysine exporter; Region: 2a75; TIGR00948 478434001338 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 478434001339 catalytic core [active] 478434001340 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 478434001341 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 478434001342 dimer interface [polypeptide binding]; other site 478434001343 phosphorylation site [posttranslational modification] 478434001344 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 478434001345 ATP binding site [chemical binding]; other site 478434001346 Mg2+ binding site [ion binding]; other site 478434001347 G-X-G motif; other site 478434001348 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 478434001349 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 478434001350 active site 478434001351 phosphorylation site [posttranslational modification] 478434001352 intermolecular recognition site; other site 478434001353 dimerization interface [polypeptide binding]; other site 478434001354 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 478434001355 DNA binding site [nucleotide binding] 478434001356 GMC oxidoreductase; Region: GMC_oxred_N; pfam00732 478434001357 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 478434001358 Transcriptional regulators [Transcription]; Region: FadR; COG2186 478434001359 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 478434001360 DNA-binding site [nucleotide binding]; DNA binding site 478434001361 FCD domain; Region: FCD; pfam07729 478434001362 exopolyphosphatase; Region: exo_poly_only; TIGR03706 478434001363 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 478434001364 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 478434001365 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 478434001366 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 478434001367 Diacylglycerol kinase catalytic domain (presumed); Region: DAGKc; smart00046 478434001368 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 478434001369 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 478434001370 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 478434001371 DNA binding domain, excisionase family; Region: excise; TIGR01764 478434001372 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 478434001373 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 478434001374 putative NAD(P) binding site [chemical binding]; other site 478434001375 active site 478434001376 putative substrate binding site [chemical binding]; other site 478434001377 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 478434001378 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 478434001379 putative acyl-acceptor binding pocket; other site 478434001380 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 478434001381 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 478434001382 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478434001383 S-adenosylmethionine binding site [chemical binding]; other site 478434001384 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 478434001385 active site 478434001386 catalytic site [active] 478434001387 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 478434001388 HAD-superfamily subfamily IB hydrolase, TIGR01490; Region: HAD-SF-IB-hyp1 478434001389 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 478434001390 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 478434001391 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 478434001392 glutamyl-tRNA reductase; Region: hemA; TIGR01035 478434001393 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 478434001394 tRNA; other site 478434001395 putative tRNA binding site [nucleotide binding]; other site 478434001396 putative NADP binding site [chemical binding]; other site 478434001397 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 478434001398 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 478434001399 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 478434001400 domain interfaces; other site 478434001401 active site 478434001402 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 478434001403 active site 478434001404 homodimer interface [polypeptide binding]; other site 478434001405 SAM binding site [chemical binding]; other site 478434001406 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 478434001407 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 478434001408 active site 478434001409 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 478434001410 dimer interface [polypeptide binding]; other site 478434001411 active site 478434001412 Schiff base residues; other site 478434001413 Domain of unknown function (DUF222); Region: DUF222; pfam02720 478434001414 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 478434001415 active site 478434001416 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 478434001417 anti sigma factor interaction site; other site 478434001418 regulatory phosphorylation site [posttranslational modification]; other site 478434001419 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 478434001420 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 478434001421 active site 478434001422 catalytic triad [active] 478434001423 oxyanion hole [active] 478434001424 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 478434001425 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478434001426 Methyltransferase domain; Region: Methyltransf_31; pfam13847 478434001427 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 478434001428 Domain of unknown function (DUF385); Region: DUF385; pfam04075 478434001429 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 478434001430 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 478434001431 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 478434001432 catalytic residue [active] 478434001433 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 478434001434 catalytic core [active] 478434001435 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 478434001436 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 478434001437 catalytic residues [active] 478434001438 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 478434001439 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 478434001440 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 478434001441 ResB-like family; Region: ResB; pfam05140 478434001442 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 478434001443 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 478434001444 AAA domain; Region: AAA_31; pfam13614 478434001445 P-loop; other site 478434001446 Magnesium ion binding site [ion binding]; other site 478434001447 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 478434001448 Protein of unknown function (DUF4229); Region: DUF4229; pfam14012 478434001449 3-oxoacyl-(acyl-carrier-protein) synthase III; Region: fabH; TIGR00747 478434001450 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 478434001451 dimer interface [polypeptide binding]; other site 478434001452 active site 478434001453 CoA binding pocket [chemical binding]; other site 478434001454 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 478434001455 UbiA prenyltransferase family; Region: UbiA; pfam01040 478434001456 5'-methylthioadenosine phosphorylase; Validated; Region: PRK07823 478434001457 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 478434001458 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 478434001459 NAD(P) binding site [chemical binding]; other site 478434001460 active site 478434001461 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 478434001462 Ligand binding site; other site 478434001463 Putative Catalytic site; other site 478434001464 DXD motif; other site 478434001465 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3222 478434001466 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 478434001467 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 478434001468 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 478434001469 acyl-activating enzyme (AAE) consensus motif; other site 478434001470 acyl-activating enzyme (AAE) consensus motif; other site 478434001471 AMP binding site [chemical binding]; other site 478434001472 active site 478434001473 CoA binding site [chemical binding]; other site 478434001474 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 478434001475 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 478434001476 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 478434001477 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 478434001478 active site 478434001479 short chain dehydrogenase; Provisional; Region: PRK05866 478434001480 classical (c) SDRs; Region: SDR_c; cd05233 478434001481 NAD(P) binding site [chemical binding]; other site 478434001482 active site 478434001483 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 478434001484 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 478434001485 substrate binding site [chemical binding]; other site 478434001486 oxyanion hole (OAH) forming residues; other site 478434001487 trimer interface [polypeptide binding]; other site 478434001488 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 478434001489 putative active site [active] 478434001490 homotetrameric interface [polypeptide binding]; other site 478434001491 metal binding site [ion binding]; metal-binding site 478434001492 Post-segregation antitoxin (ccd killing mechanism protein) encoded by the F plasmid [General function prediction only]; Region: COG5302 478434001493 acyl-CoA synthetase; Validated; Region: PRK06188 478434001494 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 478434001495 putative active site [active] 478434001496 putative CoA binding site [chemical binding]; other site 478434001497 putative AMP binding site [chemical binding]; other site 478434001498 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 478434001499 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 478434001500 active site 478434001501 O-succinylbenzoate synthase; Provisional; Region: PRK02901 478434001502 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 478434001503 active site 478434001504 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 478434001505 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 478434001506 TAP-like protein; Region: Abhydrolase_4; pfam08386 478434001507 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 478434001508 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 478434001509 dimer interface [polypeptide binding]; other site 478434001510 tetramer interface [polypeptide binding]; other site 478434001511 PYR/PP interface [polypeptide binding]; other site 478434001512 TPP binding site [chemical binding]; other site 478434001513 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 478434001514 TPP-binding site; other site 478434001515 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 478434001516 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 478434001517 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 478434001518 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 478434001519 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478434001520 S-adenosylmethionine binding site [chemical binding]; other site 478434001521 Protein of unknown function (DUF732); Region: DUF732; pfam05305 478434001522 Methyltransferase domain; Region: Methyltransf_23; pfam13489 478434001523 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478434001524 S-adenosylmethionine binding site [chemical binding]; other site 478434001525 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 478434001526 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 478434001527 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 478434001528 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 478434001529 substrate binding pocket [chemical binding]; other site 478434001530 chain length determination region; other site 478434001531 substrate-Mg2+ binding site; other site 478434001532 catalytic residues [active] 478434001533 aspartate-rich region 1; other site 478434001534 active site lid residues [active] 478434001535 aspartate-rich region 2; other site 478434001536 heat shock protein HtpX; Provisional; Region: PRK03072 478434001537 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK12439 478434001538 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 478434001539 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 478434001540 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 478434001541 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 478434001542 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 478434001543 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 478434001544 O-methyltransferase; Region: Methyltransf_2; pfam00891 478434001545 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 478434001546 Cytochrome P450; Region: p450; cl12078 478434001547 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 478434001548 ATP cone domain; Region: ATP-cone; pfam03477 478434001549 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 478434001550 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 478434001551 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 478434001552 active site 478434001553 dimer interface [polypeptide binding]; other site 478434001554 effector binding site; other site 478434001555 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 478434001556 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 478434001557 active site 478434001558 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 478434001559 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 478434001560 nicotinate phosphoribosyltransferase; Provisional; Region: PRK12484 478434001561 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 478434001562 active site 478434001563 Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane]; Region: PgsA; COG2843 478434001564 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 478434001565 putative active site [active] 478434001566 putative metal binding site [ion binding]; other site 478434001567 hypothetical protein; Provisional; Region: PRK07588 478434001568 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 478434001569 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 478434001570 dimerization interface [polypeptide binding]; other site 478434001571 putative DNA binding site [nucleotide binding]; other site 478434001572 putative Zn2+ binding site [ion binding]; other site 478434001573 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 478434001574 putative hydrophobic ligand binding site [chemical binding]; other site 478434001575 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 478434001576 TIGR03086 family protein; Region: TIGR03086 478434001577 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 478434001578 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 478434001579 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 478434001580 PE family; Region: PE; pfam00934 478434001581 Ub domain fused to Mut7-C; Region: Ub-Mut7C; pfam14451 478434001582 Uncharacterized conserved protein [Function unknown]; Region: COG1656 478434001583 Protein of unknown function DUF82; Region: DUF82; pfam01927 478434001584 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 478434001585 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 478434001586 putative active site [active] 478434001587 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 478434001588 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 478434001589 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 478434001590 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 478434001591 Transcriptional regulators [Transcription]; Region: FadR; COG2186 478434001592 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 478434001593 DNA-binding site [nucleotide binding]; DNA binding site 478434001594 FCD domain; Region: FCD; pfam07729 478434001595 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 478434001596 Permease; Region: Permease; pfam02405 478434001597 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 478434001598 Permease; Region: Permease; pfam02405 478434001599 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 478434001600 mce related protein; Region: MCE; pfam02470 478434001601 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 478434001602 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 478434001603 mce related protein; Region: MCE; pfam02470 478434001604 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 478434001605 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 478434001606 mce related protein; Region: MCE; pfam02470 478434001607 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 478434001608 mce related protein; Region: MCE; pfam02470 478434001609 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 478434001610 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 478434001611 mce related protein; Region: MCE; pfam02470 478434001612 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 478434001613 mce related protein; Region: MCE; pfam02470 478434001614 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 478434001615 oligomeric interface; other site 478434001616 putative active site [active] 478434001617 homodimer interface [polypeptide binding]; other site 478434001618 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 478434001619 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 478434001620 AAA domain; Region: AAA_14; pfam13173 478434001621 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 478434001622 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 478434001623 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 478434001624 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 478434001625 ATP binding site [chemical binding]; other site 478434001626 Mg2+ binding site [ion binding]; other site 478434001627 G-X-G motif; other site 478434001628 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 478434001629 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 478434001630 active site 478434001631 phosphorylation site [posttranslational modification] 478434001632 intermolecular recognition site; other site 478434001633 dimerization interface [polypeptide binding]; other site 478434001634 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 478434001635 DNA binding site [nucleotide binding] 478434001636 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 478434001637 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 478434001638 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 478434001639 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 478434001640 catalytic residues [active] 478434001641 catalytic nucleophile [active] 478434001642 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 478434001643 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 478434001644 Probable transposase; Region: OrfB_IS605; pfam01385 478434001645 Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704 478434001646 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 478434001647 putative active site [active] 478434001648 SEC-C motif; Region: SEC-C; pfam02810 478434001649 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB-like; cd09875 478434001650 putative active site [active] 478434001651 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 478434001652 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 478434001653 nucleotide binding site/active site [active] 478434001654 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 478434001655 galactokinase; Provisional; Region: PRK00555 478434001656 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 478434001657 Protein of unknown function (DUF732); Region: DUF732; pfam05305 478434001658 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4423 478434001659 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 478434001660 putative active site [active] 478434001661 Uncharacterized conserved protein [Function unknown]; Region: COG0398 478434001662 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 478434001663 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 478434001664 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 478434001665 oligomeric interface; other site 478434001666 putative active site [active] 478434001667 homodimer interface [polypeptide binding]; other site 478434001668 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398 478434001669 FIST N domain; Region: FIST; pfam08495 478434001670 FIST C domain; Region: FIST_C; pfam10442 478434001671 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 478434001672 AAA domain; Region: AAA_30; pfam13604 478434001673 Family description; Region: UvrD_C_2; pfam13538 478434001674 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 478434001675 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 478434001676 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 478434001677 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 478434001678 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 478434001679 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 478434001680 substrate binding site [chemical binding]; other site 478434001681 oxyanion hole (OAH) forming residues; other site 478434001682 trimer interface [polypeptide binding]; other site 478434001683 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 478434001684 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 478434001685 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 478434001686 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 478434001687 active site 478434001688 catalytic site [active] 478434001689 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 478434001690 active site 478434001691 catalytic site [active] 478434001692 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 478434001693 active site 478434001694 catalytic site [active] 478434001695 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 478434001696 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 478434001697 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 478434001698 putative homodimer interface [polypeptide binding]; other site 478434001699 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 478434001700 heterodimer interface [polypeptide binding]; other site 478434001701 homodimer interface [polypeptide binding]; other site 478434001702 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 478434001703 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 478434001704 23S rRNA interface [nucleotide binding]; other site 478434001705 L7/L12 interface [polypeptide binding]; other site 478434001706 putative thiostrepton binding site; other site 478434001707 L25 interface [polypeptide binding]; other site 478434001708 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 478434001709 mRNA/rRNA interface [nucleotide binding]; other site 478434001710 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 478434001711 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478434001712 S-adenosylmethionine binding site [chemical binding]; other site 478434001713 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 478434001714 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 478434001715 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478434001716 S-adenosylmethionine binding site [chemical binding]; other site 478434001717 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 478434001718 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 478434001719 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478434001720 S-adenosylmethionine binding site [chemical binding]; other site 478434001721 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 478434001722 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 478434001723 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478434001724 S-adenosylmethionine binding site [chemical binding]; other site 478434001725 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 478434001726 TAP-like protein; Region: Abhydrolase_4; pfam08386 478434001727 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 478434001728 ABC1 family; Region: ABC1; cl17513 478434001729 N-terminal catalytic domain of class II alpha-mannosidases and similar proteins; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_like; cd10786 478434001730 active site 478434001731 catalytic site [active] 478434001732 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 478434001733 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 478434001734 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 478434001735 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 478434001736 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 478434001737 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 478434001738 23S rRNA interface [nucleotide binding]; other site 478434001739 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 478434001740 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 478434001741 core dimer interface [polypeptide binding]; other site 478434001742 peripheral dimer interface [polypeptide binding]; other site 478434001743 L10 interface [polypeptide binding]; other site 478434001744 L11 interface [polypeptide binding]; other site 478434001745 putative EF-Tu interaction site [polypeptide binding]; other site 478434001746 putative EF-G interaction site [polypeptide binding]; other site 478434001747 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 478434001748 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478434001749 WHG domain; Region: WHG; pfam13305 478434001750 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 478434001751 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 478434001752 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 478434001753 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 478434001754 Walker A/P-loop; other site 478434001755 ATP binding site [chemical binding]; other site 478434001756 Q-loop/lid; other site 478434001757 ABC transporter signature motif; other site 478434001758 Walker B; other site 478434001759 D-loop; other site 478434001760 H-loop/switch region; other site 478434001761 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 478434001762 putative active site [active] 478434001763 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 478434001764 Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266 478434001765 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 478434001766 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG1848 478434001767 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 478434001768 Sulfatase; Region: Sulfatase; pfam00884 478434001769 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 478434001770 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 478434001771 putative active site [active] 478434001772 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 478434001773 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 478434001774 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 478434001775 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 478434001776 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 478434001777 RPB10 interaction site [polypeptide binding]; other site 478434001778 RPB1 interaction site [polypeptide binding]; other site 478434001779 RPB11 interaction site [polypeptide binding]; other site 478434001780 RPB3 interaction site [polypeptide binding]; other site 478434001781 RPB12 interaction site [polypeptide binding]; other site 478434001782 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 478434001783 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 478434001784 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 478434001785 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 478434001786 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 478434001787 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 478434001788 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 478434001789 G-loop; other site 478434001790 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 478434001791 DNA binding site [nucleotide binding] 478434001792 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 478434001793 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; pfam04734 478434001794 endonuclease IV; Provisional; Region: PRK01060 478434001795 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 478434001796 AP (apurinic/apyrimidinic) site pocket; other site 478434001797 Metal-binding active site; metal-binding site 478434001798 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 478434001799 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 478434001800 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 478434001801 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 478434001802 active site 478434001803 enoyl-CoA hydratase; Provisional; Region: PRK12478 478434001804 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 478434001805 substrate binding site [chemical binding]; other site 478434001806 oxyanion hole (OAH) forming residues; other site 478434001807 trimer interface [polypeptide binding]; other site 478434001808 Phenylacetic acid-responsive transcriptional repressor [Transcription]; Region: PaaX; COG3327 478434001809 PaaX-like protein; Region: PaaX; pfam07848 478434001810 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 478434001811 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 478434001812 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 478434001813 substrate binding site [chemical binding]; other site 478434001814 oxyanion hole (OAH) forming residues; other site 478434001815 trimer interface [polypeptide binding]; other site 478434001816 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 478434001817 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 478434001818 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 478434001819 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 478434001820 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 478434001821 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478434001822 WHG domain; Region: WHG; pfam13305 478434001823 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 478434001824 S17 interaction site [polypeptide binding]; other site 478434001825 S8 interaction site; other site 478434001826 16S rRNA interaction site [nucleotide binding]; other site 478434001827 streptomycin interaction site [chemical binding]; other site 478434001828 23S rRNA interaction site [nucleotide binding]; other site 478434001829 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 478434001830 30S ribosomal protein S7; Validated; Region: PRK05302 478434001831 elongation factor G; Reviewed; Region: PRK00007 478434001832 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 478434001833 G1 box; other site 478434001834 putative GEF interaction site [polypeptide binding]; other site 478434001835 GTP/Mg2+ binding site [chemical binding]; other site 478434001836 Switch I region; other site 478434001837 G2 box; other site 478434001838 G3 box; other site 478434001839 Switch II region; other site 478434001840 G4 box; other site 478434001841 G5 box; other site 478434001842 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 478434001843 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 478434001844 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 478434001845 elongation factor Tu; Reviewed; Region: PRK00049 478434001846 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 478434001847 G1 box; other site 478434001848 GEF interaction site [polypeptide binding]; other site 478434001849 GTP/Mg2+ binding site [chemical binding]; other site 478434001850 Switch I region; other site 478434001851 G2 box; other site 478434001852 G3 box; other site 478434001853 Switch II region; other site 478434001854 G4 box; other site 478434001855 G5 box; other site 478434001856 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 478434001857 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 478434001858 Antibiotic Binding Site [chemical binding]; other site 478434001859 Short C-terminal domain; Region: SHOCT; pfam09851 478434001860 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 478434001861 classical (c) SDRs; Region: SDR_c; cd05233 478434001862 NAD(P) binding site [chemical binding]; other site 478434001863 active site 478434001864 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 478434001865 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 478434001866 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4427 478434001867 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 478434001868 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478434001869 putative mycofactocin binding protein MftB; Region: mycofact_MftB; TIGR03967 478434001870 mycofactocin radical SAM maturase; Region: mycofact_rSAM; TIGR03962 478434001871 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 478434001872 FeS/SAM binding site; other site 478434001873 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 478434001874 heme/flavin dehydrogenase, mycofactocin system; Region: actino_HemFlav; TIGR03966 478434001875 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 478434001876 phosphate binding site [ion binding]; other site 478434001877 mycofactocin system creatininase family protein; Region: mycofact_creat; TIGR03964 478434001878 mycofactocin system glycosyltransferase; Region: mycofact_glyco; TIGR03965 478434001879 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 478434001880 Probable Catalytic site; other site 478434001881 metal-binding site 478434001882 dehydrogenase, Rv0697 family; Region: Rv0697; TIGR03970 478434001883 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 478434001884 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 478434001885 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 478434001886 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 478434001887 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 478434001888 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 478434001889 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 478434001890 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 478434001891 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 478434001892 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 478434001893 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 478434001894 putative translocon binding site; other site 478434001895 protein-rRNA interface [nucleotide binding]; other site 478434001896 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 478434001897 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 478434001898 G-X-X-G motif; other site 478434001899 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 478434001900 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 478434001901 23S rRNA interface [nucleotide binding]; other site 478434001902 5S rRNA interface [nucleotide binding]; other site 478434001903 putative antibiotic binding site [chemical binding]; other site 478434001904 L25 interface [polypeptide binding]; other site 478434001905 L27 interface [polypeptide binding]; other site 478434001906 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 478434001907 putative translocon interaction site; other site 478434001908 23S rRNA interface [nucleotide binding]; other site 478434001909 signal recognition particle (SRP54) interaction site; other site 478434001910 L23 interface [polypeptide binding]; other site 478434001911 trigger factor interaction site; other site 478434001912 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 478434001913 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 478434001914 Sulfatase; Region: Sulfatase; pfam00884 478434001915 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl17353 478434001916 Uncharacterized conserved protein [Function unknown]; Region: COG1262 478434001917 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 478434001918 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 478434001919 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 478434001920 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 478434001921 RNA binding site [nucleotide binding]; other site 478434001922 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 478434001923 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 478434001924 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 478434001925 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 478434001926 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 478434001927 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 478434001928 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 478434001929 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 478434001930 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 478434001931 5S rRNA interface [nucleotide binding]; other site 478434001932 23S rRNA interface [nucleotide binding]; other site 478434001933 L5 interface [polypeptide binding]; other site 478434001934 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 478434001935 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 478434001936 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 478434001937 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 478434001938 23S rRNA binding site [nucleotide binding]; other site 478434001939 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 478434001940 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 478434001941 tandem repeat interface [polypeptide binding]; other site 478434001942 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 478434001943 oligomer interface [polypeptide binding]; other site 478434001944 active site residues [active] 478434001945 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 478434001946 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 478434001947 tandem repeat interface [polypeptide binding]; other site 478434001948 oligomer interface [polypeptide binding]; other site 478434001949 active site residues [active] 478434001950 Leucine carboxyl methyltransferase; Region: LCM; cl01306 478434001951 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 478434001952 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 478434001953 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 478434001954 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 478434001955 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 478434001956 intersubunit interface [polypeptide binding]; other site 478434001957 active site 478434001958 Zn2+ binding site [ion binding]; other site 478434001959 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 478434001960 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 478434001961 NAD binding site [chemical binding]; other site 478434001962 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 478434001963 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 478434001964 nucleotide binding site [chemical binding]; other site 478434001965 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 478434001966 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 478434001967 Coenzyme A binding pocket [chemical binding]; other site 478434001968 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 478434001969 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 478434001970 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 478434001971 SecY translocase; Region: SecY; pfam00344 478434001972 adenylate kinase; Reviewed; Region: adk; PRK00279 478434001973 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 478434001974 AMP-binding site [chemical binding]; other site 478434001975 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 478434001976 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 478434001977 active site 478434001978 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 478434001979 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 478434001980 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 478434001981 DNA binding residues [nucleotide binding] 478434001982 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 478434001983 Putative zinc-finger; Region: zf-HC2; pfam13490 478434001984 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 478434001985 MarR family; Region: MarR; pfam01047 478434001986 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 478434001987 TIGR03086 family protein; Region: TIGR03086 478434001988 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 478434001989 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 478434001990 Transposase; Region: DDE_Tnp_ISL3; pfam01610 478434001991 Helix-turn-helix domain; Region: HTH_17; pfam12728 478434001992 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 478434001993 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 478434001994 PE family; Region: PE; pfam00934 478434001995 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 478434001996 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 478434001997 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 478434001998 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 478434001999 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 478434002000 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 478434002001 active site 478434002002 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 478434002003 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 478434002004 tetrameric interface [polypeptide binding]; other site 478434002005 NAD binding site [chemical binding]; other site 478434002006 catalytic residues [active] 478434002007 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 478434002008 catalytic core [active] 478434002009 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478434002010 PPE family; Region: PPE; pfam00823 478434002011 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478434002012 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478434002013 Helix-turn-helix domain; Region: HTH_28; pfam13518 478434002014 Winged helix-turn helix; Region: HTH_29; pfam13551 478434002015 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 478434002016 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 478434002017 active site 478434002018 phosphorylation site [posttranslational modification] 478434002019 intermolecular recognition site; other site 478434002020 dimerization interface [polypeptide binding]; other site 478434002021 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 478434002022 DNA binding site [nucleotide binding] 478434002023 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 478434002024 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 478434002025 dimerization interface [polypeptide binding]; other site 478434002026 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 478434002027 dimer interface [polypeptide binding]; other site 478434002028 phosphorylation site [posttranslational modification] 478434002029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 478434002030 ATP binding site [chemical binding]; other site 478434002031 Mg2+ binding site [ion binding]; other site 478434002032 G-X-G motif; other site 478434002033 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 478434002034 nucleotide binding site/active site [active] 478434002035 HIT family signature motif; other site 478434002036 catalytic residue [active] 478434002037 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 478434002038 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 478434002039 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 478434002040 NAD binding site [chemical binding]; other site 478434002041 catalytic Zn binding site [ion binding]; other site 478434002042 substrate binding site [chemical binding]; other site 478434002043 structural Zn binding site [ion binding]; other site 478434002044 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 478434002045 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 478434002046 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 478434002047 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 478434002048 Cytochrome P450; Region: p450; cl12078 478434002049 short chain dehydrogenase; Provisional; Region: PRK07775 478434002050 classical (c) SDRs; Region: SDR_c; cd05233 478434002051 NAD(P) binding site [chemical binding]; other site 478434002052 active site 478434002053 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 478434002054 Cytochrome P450; Region: p450; cl12078 478434002055 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 478434002056 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 478434002057 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 478434002058 NAD binding site [chemical binding]; other site 478434002059 catalytic residues [active] 478434002060 short chain dehydrogenase; Provisional; Region: PRK07774 478434002061 classical (c) SDRs; Region: SDR_c; cd05233 478434002062 NAD(P) binding site [chemical binding]; other site 478434002063 active site 478434002064 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 478434002065 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 478434002066 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 478434002067 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 478434002068 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 478434002069 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 478434002070 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 478434002071 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 478434002072 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 478434002073 Predicted esterase [General function prediction only]; Region: COG0627 478434002074 S-formylglutathione hydrolase; Region: PLN02442 478434002075 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 478434002076 Predicted nuclease (RNAse H fold) [General function prediction only]; Region: COG4328 478434002077 Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302 478434002078 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 478434002079 tetramer interface [polypeptide binding]; other site 478434002080 active site 478434002081 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 478434002082 Cytochrome P450; Region: p450; cl12078 478434002083 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 478434002084 ATP binding site [chemical binding]; other site 478434002085 active site 478434002086 substrate binding site [chemical binding]; other site 478434002087 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 478434002088 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 478434002089 WHG domain; Region: WHG; pfam13305 478434002090 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 478434002091 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 478434002092 putative substrate translocation pore; other site 478434002093 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 478434002094 Predicted deacetylase [General function prediction only]; Region: COG3233 478434002095 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374 478434002096 putative active site [active] 478434002097 putative Zn binding site [ion binding]; other site 478434002098 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 478434002099 FAD binding domain; Region: FAD_binding_2; pfam00890 478434002100 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 478434002101 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 478434002102 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 478434002103 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 478434002104 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 478434002105 putative active site [active] 478434002106 catalytic triad [active] 478434002107 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 478434002108 Transglutaminase/protease-like homologues; Region: TGc; smart00460 478434002109 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 478434002110 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 478434002111 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 478434002112 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 478434002113 DNA-binding site [nucleotide binding]; DNA binding site 478434002114 UTRA domain; Region: UTRA; pfam07702 478434002115 Uncharacterized conserved protein [Function unknown]; Region: COG1359 478434002116 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 478434002117 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 478434002118 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 478434002119 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 478434002120 Transposase; Region: DEDD_Tnp_IS110; pfam01548 478434002121 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 478434002122 Transposase; Region: DEDD_Tnp_IS110; pfam01548 478434002123 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 478434002124 Uncharacterized protein, linocin/CFP29 homolog [Function unknown]; Region: COG1659 478434002125 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 478434002126 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 478434002127 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 478434002128 active site 478434002129 metal binding site [ion binding]; metal-binding site 478434002130 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 478434002131 active site 478434002132 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 478434002133 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 478434002134 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 478434002135 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 478434002136 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 478434002137 dimerization interface [polypeptide binding]; other site 478434002138 ATP binding site [chemical binding]; other site 478434002139 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 478434002140 dimerization interface [polypeptide binding]; other site 478434002141 ATP binding site [chemical binding]; other site 478434002142 CAAX protease self-immunity; Region: Abi; pfam02517 478434002143 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 478434002144 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 478434002145 active site 478434002146 metal binding site [ion binding]; metal-binding site 478434002147 hexamer interface [polypeptide binding]; other site 478434002148 Protein of unknown function (DUF3184); Region: DUF3184; pfam11380 478434002149 amidophosphoribosyltransferase; Provisional; Region: PRK07847 478434002150 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 478434002151 active site 478434002152 tetramer interface [polypeptide binding]; other site 478434002153 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 478434002154 active site 478434002155 phosphoribosylaminoimidazole synthetase; Region: purM; TIGR00878 478434002156 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 478434002157 dimerization interface [polypeptide binding]; other site 478434002158 putative ATP binding site [chemical binding]; other site 478434002159 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 478434002160 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 478434002161 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 478434002162 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 478434002163 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 478434002164 pyridoxal 5'-phosphate binding site [chemical binding]; other site 478434002165 catalytic residue [active] 478434002166 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 478434002167 heme-binding site [chemical binding]; other site 478434002168 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 478434002169 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 478434002170 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 478434002171 active site residue [active] 478434002172 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 478434002173 active site residue [active] 478434002174 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 478434002175 catalytic residues [active] 478434002176 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 478434002177 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 478434002178 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 478434002179 DNA binding site [nucleotide binding] 478434002180 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 478434002181 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 478434002182 Coenzyme A binding pocket [chemical binding]; other site 478434002183 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 478434002184 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 478434002185 Walker A/P-loop; other site 478434002186 ATP binding site [chemical binding]; other site 478434002187 Q-loop/lid; other site 478434002188 ABC transporter signature motif; other site 478434002189 Walker B; other site 478434002190 D-loop; other site 478434002191 H-loop/switch region; other site 478434002192 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 478434002193 PhoU domain; Region: PhoU; pfam01895 478434002194 PhoU domain; Region: PhoU; pfam01895 478434002195 cell envelope-related function transcriptional attenuator common domain; Region: lytR_cpsA_psr; TIGR00350 478434002196 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 478434002197 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 478434002198 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 478434002199 FMN binding site [chemical binding]; other site 478434002200 active site 478434002201 catalytic residues [active] 478434002202 substrate binding site [chemical binding]; other site 478434002203 Fatty acid desaturase; Region: FA_desaturase_2; pfam03405 478434002204 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 478434002205 homodimer interface [polypeptide binding]; other site 478434002206 putative substrate binding pocket [chemical binding]; other site 478434002207 diiron center [ion binding]; other site 478434002208 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 478434002209 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 478434002210 dimerization interface [polypeptide binding]; other site 478434002211 putative DNA binding site [nucleotide binding]; other site 478434002212 putative Zn2+ binding site [ion binding]; other site 478434002213 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 478434002214 dimer interface [polypeptide binding]; other site 478434002215 catalytic motif [active] 478434002216 nucleoside/Zn binding site; other site 478434002217 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 478434002218 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 478434002219 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 478434002220 TIGR04255 family protein; Region: sporadTIGR04255 478434002221 PE family; Region: PE; pfam00934 478434002222 PE family; Region: PE; pfam00934 478434002223 PknH-like extracellular domain; Region: PknH_C; pfam14032 478434002224 putative transposase OrfB; Reviewed; Region: PHA02517 478434002225 HTH-like domain; Region: HTH_21; pfam13276 478434002226 Integrase core domain; Region: rve; pfam00665 478434002227 Integrase core domain; Region: rve_3; pfam13683 478434002228 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 478434002229 Transposase; Region: HTH_Tnp_1; cl17663 478434002230 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 478434002231 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 478434002232 MoaE interaction surface [polypeptide binding]; other site 478434002233 MoeB interaction surface [polypeptide binding]; other site 478434002234 thiocarboxylated glycine; other site 478434002235 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 478434002236 trimer interface [polypeptide binding]; other site 478434002237 dimer interface [polypeptide binding]; other site 478434002238 putative active site [active] 478434002239 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 478434002240 aromatic arch; other site 478434002241 DCoH dimer interaction site [polypeptide binding]; other site 478434002242 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 478434002243 DCoH tetramer interaction site [polypeptide binding]; other site 478434002244 substrate binding site [chemical binding]; other site 478434002245 Molybdenum cofactor biosynthesis enzyme [Coenzyme metabolism]; Region: MoaA; COG2896 478434002246 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 478434002247 FeS/SAM binding site; other site 478434002248 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 478434002249 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 478434002250 FAD binding domain; Region: FAD_binding_4; pfam01565 478434002251 ferredoxin-NADP+ reductase; Region: PLN02852 478434002252 peptide chain release factor 2; Validated; Region: prfB; PRK00578 478434002253 This domain is found in peptide chain release factors; Region: PCRF; smart00937 478434002254 RF-1 domain; Region: RF-1; pfam00472 478434002255 Mechanosensitive ion channel; Region: MS_channel; pfam00924 478434002256 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 478434002257 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 478434002258 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 478434002259 Walker A/P-loop; other site 478434002260 ATP binding site [chemical binding]; other site 478434002261 Q-loop/lid; other site 478434002262 ABC transporter signature motif; other site 478434002263 Walker B; other site 478434002264 D-loop; other site 478434002265 H-loop/switch region; other site 478434002266 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 478434002267 FtsX-like permease family; Region: FtsX; pfam02687 478434002268 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 478434002269 SmpB-tmRNA interface; other site 478434002270 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 478434002271 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 478434002272 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 478434002273 PemK-like protein; Region: PemK; pfam02452 478434002274 PE family; Region: PE; pfam00934 478434002275 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 478434002276 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 478434002277 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 478434002278 Predicted transcriptional regulators [Transcription]; Region: COG1733 478434002279 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 478434002280 dimerization interface [polypeptide binding]; other site 478434002281 putative DNA binding site [nucleotide binding]; other site 478434002282 putative Zn2+ binding site [ion binding]; other site 478434002283 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 478434002284 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 478434002285 active site 478434002286 probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841 478434002287 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 478434002288 Protein of unknown function (DUF808); Region: DUF808; cl01002 478434002289 Patatin-like phospholipase; Region: Patatin; pfam01734 478434002290 SPFH domain / Band 7 family; Region: Band_7; pfam01145 478434002291 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 478434002292 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 478434002293 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 478434002294 acyl-activating enzyme (AAE) consensus motif; other site 478434002295 AMP binding site [chemical binding]; other site 478434002296 active site 478434002297 CoA binding site [chemical binding]; other site 478434002298 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 478434002299 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 478434002300 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 478434002301 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 478434002302 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 478434002303 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 478434002304 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 478434002305 NAD binding site [chemical binding]; other site 478434002306 catalytic Zn binding site [ion binding]; other site 478434002307 substrate binding site [chemical binding]; other site 478434002308 structural Zn binding site [ion binding]; other site 478434002309 short chain dehydrogenase; Provisional; Region: PRK07832 478434002310 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 478434002311 NAD(P) binding site [chemical binding]; other site 478434002312 active site 478434002313 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 478434002314 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 478434002315 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 478434002316 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 478434002317 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 478434002318 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 478434002319 Nucleotidyl transferase of unknown function (DUF2204); Region: DUF2204; pfam09970 478434002320 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 478434002321 Catalytic domain of Protein Kinases; Region: PKc; cd00180 478434002322 active site 478434002323 ATP binding site [chemical binding]; other site 478434002324 substrate binding site [chemical binding]; other site 478434002325 activation loop (A-loop); other site 478434002326 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 478434002327 AAA ATPase domain; Region: AAA_16; pfam13191 478434002328 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 478434002329 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 478434002330 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 478434002331 Sulfatase; Region: Sulfatase; pfam00884 478434002332 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 478434002333 putative hydrophobic ligand binding site [chemical binding]; other site 478434002334 protein interface [polypeptide binding]; other site 478434002335 gate; other site 478434002336 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 478434002337 Domain of unknown function (DUF222); Region: DUF222; pfam02720 478434002338 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 478434002339 active site 478434002340 Uncharacterized conserved protein [Function unknown]; Region: COG3189 478434002341 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 478434002342 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 478434002343 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 478434002344 Uncharacterized ACR, COG1993; Region: DUF190; pfam02641 478434002345 camphor resistance protein CrcB; Provisional; Region: PRK14228 478434002346 camphor resistance protein CrcB; Provisional; Region: PRK14216 478434002347 phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132 478434002348 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 478434002349 active site 478434002350 substrate binding site [chemical binding]; other site 478434002351 metal binding site [ion binding]; metal-binding site 478434002352 Protein of unknown function (DUF732); Region: DUF732; pfam05305 478434002353 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 478434002354 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478434002355 Small Multidrug Resistance protein; Region: Multi_Drug_Res; pfam00893 478434002356 Predicted membrane protein [Function unknown]; Region: COG2259 478434002357 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 478434002358 Carbon starvation protein CstA; Region: CstA; pfam02554 478434002359 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 478434002360 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180 478434002361 Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901 478434002362 active site 478434002363 DNA binding site [nucleotide binding] 478434002364 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 478434002365 DNA binding site [nucleotide binding] 478434002366 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 478434002367 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 478434002368 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 478434002369 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 478434002370 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 478434002371 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 478434002372 active site 478434002373 Transcriptional regulators [Transcription]; Region: FadR; COG2186 478434002374 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 478434002375 DNA-binding site [nucleotide binding]; DNA binding site 478434002376 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 478434002377 Transcriptional regulators [Transcription]; Region: FadR; COG2186 478434002378 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 478434002379 DNA-binding site [nucleotide binding]; DNA binding site 478434002380 FCD domain; Region: FCD; pfam07729 478434002381 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 478434002382 Cytochrome P450; Region: p450; cl12078 478434002383 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 478434002384 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478434002385 short chain dehydrogenase; Provisional; Region: PRK07832 478434002386 classical (c) SDRs; Region: SDR_c; cd05233 478434002387 NAD(P) binding site [chemical binding]; other site 478434002388 active site 478434002389 DNA polymerase IV; Validated; Region: PRK03352 478434002390 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 478434002391 active site 478434002392 DNA binding site [nucleotide binding] 478434002393 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 478434002394 Predicted flavoprotein [General function prediction only]; Region: COG0431 478434002395 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 478434002396 catalytic residues [active] 478434002397 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 478434002398 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 478434002399 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 478434002400 Class I ribonucleotide reductase; Region: RNR_I; cd01679 478434002401 active site 478434002402 dimer interface [polypeptide binding]; other site 478434002403 catalytic residues [active] 478434002404 effector binding site; other site 478434002405 R2 peptide binding site; other site 478434002406 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 478434002407 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478434002408 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 478434002409 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 478434002410 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 478434002411 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 478434002412 dimer interface [polypeptide binding]; other site 478434002413 putative radical transfer pathway; other site 478434002414 diiron center [ion binding]; other site 478434002415 tyrosyl radical; other site 478434002416 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 478434002417 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 478434002418 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 478434002419 putative NAD(P) binding site [chemical binding]; other site 478434002420 putative substrate binding site [chemical binding]; other site 478434002421 catalytic Zn binding site [ion binding]; other site 478434002422 structural Zn binding site [ion binding]; other site 478434002423 dimer interface [polypeptide binding]; other site 478434002424 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 478434002425 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 478434002426 siderophore binding site; other site 478434002427 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 478434002428 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 478434002429 D-pathway; other site 478434002430 Putative ubiquinol binding site [chemical binding]; other site 478434002431 Low-spin heme (heme b) binding site [chemical binding]; other site 478434002432 Putative water exit pathway; other site 478434002433 Binuclear center (heme o3/CuB) [ion binding]; other site 478434002434 K-pathway; other site 478434002435 Putative proton exit pathway; other site 478434002436 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 478434002437 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 478434002438 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 478434002439 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 478434002440 motif II; other site 478434002441 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119 478434002442 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 478434002443 Walker A/P-loop; other site 478434002444 ATP binding site [chemical binding]; other site 478434002445 Q-loop/lid; other site 478434002446 ABC transporter signature motif; other site 478434002447 Walker B; other site 478434002448 D-loop; other site 478434002449 H-loop/switch region; other site 478434002450 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 478434002451 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 478434002452 substrate binding site [chemical binding]; other site 478434002453 oxyanion hole (OAH) forming residues; other site 478434002454 trimer interface [polypeptide binding]; other site 478434002455 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478434002456 S-adenosylmethionine binding site [chemical binding]; other site 478434002457 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 478434002458 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 478434002459 FOG: WD40-like repeat [Function unknown]; Region: COG1520 478434002460 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 478434002461 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 478434002462 trimer interface [polypeptide binding]; other site 478434002463 active site 478434002464 substrate binding site [chemical binding]; other site 478434002465 CoA binding site [chemical binding]; other site 478434002466 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 478434002467 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 478434002468 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 478434002469 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 478434002470 Uncharacterized conserved protein [Function unknown]; Region: COG1543 478434002471 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 478434002472 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 478434002473 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478434002474 S-adenosylmethionine binding site [chemical binding]; other site 478434002475 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 478434002476 Ligand binding site [chemical binding]; other site 478434002477 Electron transfer flavoprotein domain; Region: ETF; pfam01012 478434002478 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 478434002479 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 478434002480 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 478434002481 Putative hemolysin [General function prediction only]; Region: COG3176 478434002482 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 478434002483 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 478434002484 putative acyl-acceptor binding pocket; other site 478434002485 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 478434002486 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 478434002487 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 478434002488 catalytic residue [active] 478434002489 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 478434002490 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 478434002491 Ligand Binding Site [chemical binding]; other site 478434002492 Transposase, Mutator family; Region: Transposase_mut; pfam00872 478434002493 MULE transposase domain; Region: MULE; pfam10551 478434002494 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478434002495 PPE family; Region: PPE; pfam00823 478434002496 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 478434002497 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478434002498 PPE family; Region: PPE; pfam00823 478434002499 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 478434002500 PknH-like extracellular domain; Region: PknH_C; pfam14032 478434002501 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310 478434002502 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 478434002503 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 478434002504 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 478434002505 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 478434002506 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 478434002507 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 478434002508 Dimer interface [polypeptide binding]; other site 478434002509 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 478434002510 aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, C subunit; Region: gatC; TIGR00135 478434002511 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 478434002512 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 478434002513 6-phosphofructokinase; Provisional; Region: PRK03202 478434002514 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 478434002515 active site 478434002516 ADP/pyrophosphate binding site [chemical binding]; other site 478434002517 dimerization interface [polypeptide binding]; other site 478434002518 allosteric effector site; other site 478434002519 fructose-1,6-bisphosphate binding site; other site 478434002520 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 478434002521 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 478434002522 GatB domain; Region: GatB_Yqey; smart00845 478434002523 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 478434002524 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 478434002525 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 478434002526 Predicted membrane protein [Function unknown]; Region: COG2259 478434002527 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 478434002528 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 478434002529 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 478434002530 PYR/PP interface [polypeptide binding]; other site 478434002531 dimer interface [polypeptide binding]; other site 478434002532 TPP binding site [chemical binding]; other site 478434002533 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 478434002534 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 478434002535 TPP-binding site [chemical binding]; other site 478434002536 dimer interface [polypeptide binding]; other site 478434002537 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 478434002538 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 478434002539 putative valine binding site [chemical binding]; other site 478434002540 dimer interface [polypeptide binding]; other site 478434002541 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 478434002542 ketol-acid reductoisomerase; Provisional; Region: PRK05479 478434002543 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 478434002544 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 478434002545 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 478434002546 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 478434002547 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 478434002548 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 478434002549 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 478434002550 phosphorylation site [posttranslational modification] 478434002551 Protein of unknown function (DUF433); Region: DUF433; pfam04255 478434002552 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 478434002553 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 478434002554 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 478434002555 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 478434002556 ligand binding site [chemical binding]; other site 478434002557 NAD binding site [chemical binding]; other site 478434002558 dimerization interface [polypeptide binding]; other site 478434002559 catalytic site [active] 478434002560 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 478434002561 putative L-serine binding site [chemical binding]; other site 478434002562 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 478434002563 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 478434002564 Major Facilitator Superfamily; Region: MFS_1; pfam07690 478434002565 putative substrate translocation pore; other site 478434002566 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 478434002567 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 478434002568 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 478434002569 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 478434002570 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 478434002571 active site 478434002572 HIGH motif; other site 478434002573 nucleotide binding site [chemical binding]; other site 478434002574 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 478434002575 active site 478434002576 KMSKS motif; other site 478434002577 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 478434002578 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 478434002579 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478434002580 S-adenosylmethionine binding site [chemical binding]; other site 478434002581 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 478434002582 Transcriptional regulator [Transcription]; Region: IclR; COG1414 478434002583 Bacterial transcriptional regulator; Region: IclR; pfam01614 478434002584 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 478434002585 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 478434002586 substrate binding site [chemical binding]; other site 478434002587 ligand binding site [chemical binding]; other site 478434002588 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 478434002589 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 478434002590 substrate binding site [chemical binding]; other site 478434002591 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 478434002592 IHF - DNA interface [nucleotide binding]; other site 478434002593 IHF dimer interface [polypeptide binding]; other site 478434002594 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 478434002595 active site 478434002596 Ap6A binding site [chemical binding]; other site 478434002597 nudix motif; other site 478434002598 metal binding site [ion binding]; metal-binding site 478434002599 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 478434002600 catalytic core [active] 478434002601 polyphosphate kinase; Provisional; Region: PRK05443 478434002602 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 478434002603 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 478434002604 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 478434002605 putative domain interface [polypeptide binding]; other site 478434002606 putative active site [active] 478434002607 catalytic site [active] 478434002608 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 478434002609 putative domain interface [polypeptide binding]; other site 478434002610 putative active site [active] 478434002611 catalytic site [active] 478434002612 Predicted nucleotidyltransferase, CobY/MobA/RfbA family [General function prediction only]; Region: COG1920 478434002613 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 478434002614 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 478434002615 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 478434002616 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 478434002617 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 478434002618 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 478434002619 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 478434002620 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 478434002621 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 478434002622 catalytic residues [active] 478434002623 catalytic nucleophile [active] 478434002624 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 478434002625 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 478434002626 Probable transposase; Region: OrfB_IS605; pfam01385 478434002627 thiamine monophosphate kinase; Provisional; Region: PRK05731 478434002628 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 478434002629 ATP binding site [chemical binding]; other site 478434002630 dimerization interface [polypeptide binding]; other site 478434002631 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 478434002632 ligand binding site [chemical binding]; other site 478434002633 active site 478434002634 UGI interface [polypeptide binding]; other site 478434002635 catalytic site [active] 478434002636 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 478434002637 DAK2 domain; Region: Dak2; cl03685 478434002638 DAK2 domain; Region: Dak2; cl03685 478434002639 Dihydroxyacetone kinase family; Region: Dak1_2; pfam13684 478434002640 RecG-like helicase [DNA replication, recombination, and repair / Transcription]; Region: RecG; COG1200 478434002641 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 478434002642 generic binding surface II; other site 478434002643 ssDNA binding site; other site 478434002644 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 478434002645 ATP binding site [chemical binding]; other site 478434002646 putative Mg++ binding site [ion binding]; other site 478434002647 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 478434002648 nucleotide binding region [chemical binding]; other site 478434002649 ATP-binding site [chemical binding]; other site 478434002650 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 478434002651 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 478434002652 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 478434002653 active site 478434002654 catalytic tetrad [active] 478434002655 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 478434002656 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 478434002657 substrate binding pocket [chemical binding]; other site 478434002658 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 478434002659 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 478434002660 catalytic residues [active] 478434002661 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 478434002662 putative active site [active] 478434002663 redox center [active] 478434002664 pyruvate carboxylase; Reviewed; Region: PRK12999 478434002665 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 478434002666 ATP-grasp domain; Region: ATP-grasp_4; cl17255 478434002667 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 478434002668 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 478434002669 active site 478434002670 catalytic residues [active] 478434002671 metal binding site [ion binding]; metal-binding site 478434002672 homodimer binding site [polypeptide binding]; other site 478434002673 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 478434002674 carboxyltransferase (CT) interaction site; other site 478434002675 biotinylation site [posttranslational modification]; other site 478434002676 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 478434002677 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478434002678 S-adenosylmethionine binding site [chemical binding]; other site 478434002679 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 478434002680 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 478434002681 active site 478434002682 (T/H)XGH motif; other site 478434002683 formyltetrahydrofolate deformylase; Region: PurU; TIGR00655 478434002684 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 478434002685 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 478434002686 putative active site [active] 478434002687 putative substrate binding site [chemical binding]; other site 478434002688 putative cosubstrate binding site; other site 478434002689 catalytic site [active] 478434002690 Predicted permease; Region: DUF318; pfam03773 478434002691 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 478434002692 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 478434002693 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 478434002694 Cephalosporin hydroxylase [Defense mechanisms]; Region: CmcI; COG3510 478434002695 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 478434002696 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 478434002697 active site 478434002698 TDP-binding site; other site 478434002699 acceptor substrate-binding pocket; other site 478434002700 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 478434002701 metal-binding site 478434002702 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 478434002703 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 478434002704 Methyltransferase domain; Region: Methyltransf_23; pfam13489 478434002705 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478434002706 S-adenosylmethionine binding site [chemical binding]; other site 478434002707 Uncharacterized conserved protein [Function unknown]; Region: COG3268 478434002708 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478434002709 S-adenosylmethionine binding site [chemical binding]; other site 478434002710 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 478434002711 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 478434002712 acyl-CoA synthetase; Validated; Region: PRK05850 478434002713 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 478434002714 acyl-activating enzyme (AAE) consensus motif; other site 478434002715 active site 478434002716 4-hydroxybenzoate synthetase (chorismate lyase) [Coenzyme metabolism]; Region: UbiC; COG3161 478434002717 acyl-CoA synthetase; Validated; Region: PRK06060 478434002718 Benzoate CoA ligase (BCL) and similar adenylate forming enzymes; Region: BCL_like; cd05919 478434002719 dimer interface [polypeptide binding]; other site 478434002720 acyl-activating enzyme (AAE) consensus motif; other site 478434002721 putative active site [active] 478434002722 putative AMP binding site [chemical binding]; other site 478434002723 putative CoA binding site [chemical binding]; other site 478434002724 chemical substrate binding site [chemical binding]; other site 478434002725 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 478434002726 potential frameshift: common BLAST hit: gi|148824136|ref|YP_001288890.1| polyketide synthase pks15 478434002727 Erythronolide synthase docking; Region: Docking; pfam08990 478434002728 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 478434002729 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 478434002730 active site 478434002731 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 478434002732 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 478434002733 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 478434002734 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 478434002735 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 478434002736 Enoylreductase; Region: PKS_ER; smart00829 478434002737 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 478434002738 NAD(P) binding site [chemical binding]; other site 478434002739 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 478434002740 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 478434002741 putative NADP binding site [chemical binding]; other site 478434002742 active site 478434002743 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 478434002744 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 478434002745 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 478434002746 ATP binding site [chemical binding]; other site 478434002747 Walker A motif; other site 478434002748 Walker B motif; other site 478434002749 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 478434002750 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 478434002751 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 478434002752 Integrase core domain; Region: rve; pfam00665 478434002753 MMPL family; Region: MMPL; pfam03176 478434002754 acyl-CoA synthetase; Validated; Region: PRK05850 478434002755 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 478434002756 acyl-activating enzyme (AAE) consensus motif; other site 478434002757 active site 478434002758 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 478434002759 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 478434002760 active site 478434002761 Acyl transferase domain; Region: Acyl_transf_1; pfam00698 478434002762 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 478434002763 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 478434002764 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 478434002765 Enoylreductase; Region: PKS_ER; smart00829 478434002766 NAD(P) binding site [chemical binding]; other site 478434002767 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 478434002768 KR domain; Region: KR; pfam08659 478434002769 putative NADP binding site [chemical binding]; other site 478434002770 active site 478434002771 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 478434002772 acyltransferase PapA5; Provisional; Region: PRK09294 478434002773 ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025 478434002774 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 478434002775 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 478434002776 ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025 478434002777 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 478434002778 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 478434002779 Walker A/P-loop; other site 478434002780 ATP binding site [chemical binding]; other site 478434002781 Q-loop/lid; other site 478434002782 ABC transporter signature motif; other site 478434002783 Walker B; other site 478434002784 D-loop; other site 478434002785 H-loop/switch region; other site 478434002786 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 478434002787 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 478434002788 active site 478434002789 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 478434002790 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 478434002791 Condensation domain; Region: Condensation; pfam00668 478434002792 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 478434002793 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 478434002794 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 478434002795 active site 478434002796 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 478434002797 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 478434002798 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 478434002799 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 478434002800 active site 478434002801 Acyl transferase domain; Region: Acyl_transf_1; cl08282 478434002802 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 478434002803 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 478434002804 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 478434002805 Enoylreductase; Region: PKS_ER; smart00829 478434002806 NAD(P) binding site [chemical binding]; other site 478434002807 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 478434002808 KR domain; Region: KR; pfam08659 478434002809 putative NADP binding site [chemical binding]; other site 478434002810 active site 478434002811 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 478434002812 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 478434002813 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 478434002814 active site 478434002815 Acyl transferase domain; Region: Acyl_transf_1; cl08282 478434002816 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 478434002817 KR domain; Region: KR; pfam08659 478434002818 NADP binding site [chemical binding]; other site 478434002819 active site 478434002820 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 478434002821 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 478434002822 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 478434002823 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 478434002824 active site 478434002825 Acyl transferase domain; Region: Acyl_transf_1; pfam00698 478434002826 acyl-CoA synthetase; Validated; Region: PRK05850 478434002827 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 478434002828 acyl-activating enzyme (AAE) consensus motif; other site 478434002829 active site 478434002830 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 478434002831 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 478434002832 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 478434002833 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 478434002834 ribonuclease III; Reviewed; Region: rnc; PRK00102 478434002835 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 478434002836 dimerization interface [polypeptide binding]; other site 478434002837 active site 478434002838 metal binding site [ion binding]; metal-binding site 478434002839 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 478434002840 dsRNA binding site [nucleotide binding]; other site 478434002841 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 478434002842 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 478434002843 DNA binding site [nucleotide binding] 478434002844 catalytic residue [active] 478434002845 H2TH interface [polypeptide binding]; other site 478434002846 putative catalytic residues [active] 478434002847 turnover-facilitating residue; other site 478434002848 intercalation triad [nucleotide binding]; other site 478434002849 8OG recognition residue [nucleotide binding]; other site 478434002850 putative reading head residues; other site 478434002851 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 478434002852 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 478434002853 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 478434002854 acylphosphatase; Provisional; Region: PRK14422 478434002855 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 478434002856 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 478434002857 Walker A/P-loop; other site 478434002858 ATP binding site [chemical binding]; other site 478434002859 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 478434002860 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 478434002861 ABC transporter signature motif; other site 478434002862 Walker B; other site 478434002863 D-loop; other site 478434002864 H-loop/switch region; other site 478434002865 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 478434002866 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 478434002867 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 478434002868 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 478434002869 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 478434002870 Nitrogen regulatory protein P-II; Region: P-II; smart00938 478434002871 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 478434002872 metal binding triad [ion binding]; metal-binding site 478434002873 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 478434002874 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 478434002875 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 478434002876 ATP binding site [chemical binding]; other site 478434002877 putative Mg++ binding site [ion binding]; other site 478434002878 signal recognition particle protein; Provisional; Region: PRK10867 478434002879 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 478434002880 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 478434002881 P loop; other site 478434002882 GTP binding site [chemical binding]; other site 478434002883 Signal peptide binding domain; Region: SRP_SPB; pfam02978 478434002884 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 478434002885 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 478434002886 active site 478434002887 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 478434002888 Catalytic domain of Protein Kinases; Region: PKc; cd00180 478434002889 active site 478434002890 ATP binding site [chemical binding]; other site 478434002891 substrate binding site [chemical binding]; other site 478434002892 activation loop (A-loop); other site 478434002893 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 478434002894 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 478434002895 active site 478434002896 putative substrate binding pocket [chemical binding]; other site 478434002897 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 478434002898 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 478434002899 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478434002900 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 478434002901 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 478434002902 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 478434002903 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 478434002904 hypothetical protein; Provisional; Region: PRK02821 478434002905 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 478434002906 G-X-X-G motif; other site 478434002907 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 478434002908 RimM N-terminal domain; Region: RimM; pfam01782 478434002909 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 478434002910 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 478434002911 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 478434002912 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 478434002913 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 478434002914 Catalytic site [active] 478434002915 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 478434002916 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 478434002917 RNA/DNA hybrid binding site [nucleotide binding]; other site 478434002918 active site 478434002919 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 478434002920 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 478434002921 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 478434002922 putative molybdopterin cofactor binding site [chemical binding]; other site 478434002923 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 478434002924 putative molybdopterin cofactor binding site; other site 478434002925 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 478434002926 hypothetical protein; Reviewed; Region: PRK12497 478434002927 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 478434002928 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 478434002929 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 478434002930 Walker A motif; other site 478434002931 ATP binding site [chemical binding]; other site 478434002932 Walker B motif; other site 478434002933 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 478434002934 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 478434002935 DNA protecting protein DprA; Region: dprA; TIGR00732 478434002936 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 478434002937 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 478434002938 FAD binding pocket [chemical binding]; other site 478434002939 FAD binding motif [chemical binding]; other site 478434002940 phosphate binding motif [ion binding]; other site 478434002941 NAD binding pocket [chemical binding]; other site 478434002942 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 478434002943 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 478434002944 active site 478434002945 DNA binding site [nucleotide binding] 478434002946 Int/Topo IB signature motif; other site 478434002947 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 478434002948 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 478434002949 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478434002950 PPE family; Region: PPE; pfam00823 478434002951 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 478434002952 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 478434002953 Peptidase family M23; Region: Peptidase_M23; pfam01551 478434002954 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 478434002955 rRNA interaction site [nucleotide binding]; other site 478434002956 S8 interaction site; other site 478434002957 putative laminin-1 binding site; other site 478434002958 elongation factor Ts; Provisional; Region: tsf; PRK09377 478434002959 UBA/TS-N domain; Region: UBA; pfam00627 478434002960 Elongation factor TS; Region: EF_TS; pfam00889 478434002961 Elongation factor TS; Region: EF_TS; pfam00889 478434002962 amidase; Provisional; Region: PRK07869 478434002963 Amidase; Region: Amidase; pfam01425 478434002964 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 478434002965 MarR family; Region: MarR; pfam01047 478434002966 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 478434002967 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 478434002968 catalytic residues [active] 478434002969 catalytic nucleophile [active] 478434002970 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 478434002971 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 478434002972 Probable transposase; Region: OrfB_IS605; pfam01385 478434002973 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 478434002974 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 478434002975 DNA binding site [nucleotide binding] 478434002976 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 478434002977 putative nucleotide binding site [chemical binding]; other site 478434002978 uridine monophosphate binding site [chemical binding]; other site 478434002979 homohexameric interface [polypeptide binding]; other site 478434002980 ribosome recycling factor; Reviewed; Region: frr; PRK00083 478434002981 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 478434002982 hinge region; other site 478434002983 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 478434002984 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 478434002985 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 478434002986 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 478434002987 FeS/SAM binding site; other site 478434002988 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 478434002989 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 478434002990 catalytic residues [active] 478434002991 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 478434002992 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 478434002993 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 478434002994 Fasciclin domain; Region: Fasciclin; pfam02469 478434002995 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 478434002996 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 478434002997 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 478434002998 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 478434002999 catalytic residues [active] 478434003000 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 478434003001 Fasciclin domain; Region: Fasciclin; pfam02469 478434003002 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 478434003003 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 478434003004 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 478434003005 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 478434003006 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 478434003007 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 478434003008 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 478434003009 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 478434003010 active site 478434003011 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 478434003012 protein binding site [polypeptide binding]; other site 478434003013 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 478434003014 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 478434003015 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 478434003016 Predicted acetyltransferase [General function prediction only]; Region: COG3393 478434003017 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 478434003018 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 478434003019 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 478434003020 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 478434003021 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 478434003022 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 478434003023 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 478434003024 putative active site [active] 478434003025 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 478434003026 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 478434003027 active site 478434003028 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 478434003029 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 478434003030 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 478434003031 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 478434003032 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 478434003033 catalytic triad [active] 478434003034 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 478434003035 NAD(P)+ dependent aldehyde dehydrogenase family; Region: ALDH; cd07078 478434003036 NAD(P) binding site [chemical binding]; other site 478434003037 catalytic residues [active] 478434003038 short chain dehydrogenase; Provisional; Region: PRK06057 478434003039 classical (c) SDRs; Region: SDR_c; cd05233 478434003040 NAD(P) binding site [chemical binding]; other site 478434003041 active site 478434003042 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 478434003043 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 478434003044 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 478434003045 mycothione reductase; Reviewed; Region: PRK07846 478434003046 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 478434003047 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 478434003048 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 478434003049 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 478434003050 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 478434003051 PE family; Region: PE; pfam00934 478434003052 malate:quinone oxidoreductase; Validated; Region: PRK05257 478434003053 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 478434003054 Predicted acyltransferase [General function prediction only]; Region: ElaA; COG2153 478434003055 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 478434003056 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 478434003057 Walker A motif; other site 478434003058 ATP binding site [chemical binding]; other site 478434003059 Walker B motif; other site 478434003060 arginine finger; other site 478434003061 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 478434003062 metal ion-dependent adhesion site (MIDAS); other site 478434003063 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 478434003064 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 478434003065 homodimer interface [polypeptide binding]; other site 478434003066 Walker A motif; other site 478434003067 ATP binding site [chemical binding]; other site 478434003068 hydroxycobalamin binding site [chemical binding]; other site 478434003069 Walker B motif; other site 478434003070 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 478434003071 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 478434003072 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 478434003073 catalytic triad [active] 478434003074 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 478434003075 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 478434003076 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 478434003077 homodimer interface [polypeptide binding]; other site 478434003078 active site 478434003079 SAM binding site [chemical binding]; other site 478434003080 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 478434003081 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 478434003082 putative substrate translocation pore; other site 478434003083 prolyl-tRNA synthetase; Provisional; Region: PRK09194 478434003084 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 478434003085 dimer interface [polypeptide binding]; other site 478434003086 motif 1; other site 478434003087 active site 478434003088 motif 2; other site 478434003089 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 478434003090 putative deacylase active site [active] 478434003091 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 478434003092 active site 478434003093 motif 3; other site 478434003094 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 478434003095 anticodon binding site; other site 478434003096 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 478434003097 dinuclear metal binding motif [ion binding]; other site 478434003098 ribosome maturation protein RimP; Reviewed; Region: PRK00092 478434003099 Sm and related proteins; Region: Sm_like; cl00259 478434003100 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 478434003101 putative oligomer interface [polypeptide binding]; other site 478434003102 putative RNA binding site [nucleotide binding]; other site 478434003103 Mitochondrial ATP synthase g subunit; Region: ATP-synt_G; pfam04718 478434003104 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 478434003105 NusA N-terminal domain; Region: NusA_N; pfam08529 478434003106 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 478434003107 RNA binding site [nucleotide binding]; other site 478434003108 homodimer interface [polypeptide binding]; other site 478434003109 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 478434003110 G-X-X-G motif; other site 478434003111 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 478434003112 G-X-X-G motif; other site 478434003113 Predicted nucleic-acid-binding protein implicated in transcription termination [Transcription]; Region: COG2740 478434003114 putative RNA binding cleft [nucleotide binding]; other site 478434003115 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 478434003116 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 478434003117 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 478434003118 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 478434003119 G1 box; other site 478434003120 putative GEF interaction site [polypeptide binding]; other site 478434003121 GTP/Mg2+ binding site [chemical binding]; other site 478434003122 Switch I region; other site 478434003123 G2 box; other site 478434003124 G3 box; other site 478434003125 Switch II region; other site 478434003126 G4 box; other site 478434003127 G5 box; other site 478434003128 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 478434003129 Translation-initiation factor 2; Region: IF-2; pfam11987 478434003130 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 478434003131 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 478434003132 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 478434003133 DHH family; Region: DHH; pfam01368 478434003134 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 478434003135 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 478434003136 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 478434003137 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 478434003138 dimer interface [polypeptide binding]; other site 478434003139 conserved gate region; other site 478434003140 putative PBP binding loops; other site 478434003141 ABC-ATPase subunit interface; other site 478434003142 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 478434003143 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 478434003144 dimer interface [polypeptide binding]; other site 478434003145 conserved gate region; other site 478434003146 putative PBP binding loops; other site 478434003147 ABC-ATPase subunit interface; other site 478434003148 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 478434003149 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 478434003150 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 478434003151 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 478434003152 Walker A/P-loop; other site 478434003153 ATP binding site [chemical binding]; other site 478434003154 Q-loop/lid; other site 478434003155 ABC transporter signature motif; other site 478434003156 Walker B; other site 478434003157 D-loop; other site 478434003158 H-loop/switch region; other site 478434003159 enoyl-CoA hydratase; Provisional; Region: PRK06190 478434003160 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 478434003161 substrate binding site [chemical binding]; other site 478434003162 oxyanion hole (OAH) forming residues; other site 478434003163 trimer interface [polypeptide binding]; other site 478434003164 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 478434003165 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 478434003166 putative active site [active] 478434003167 Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041 478434003168 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4293 478434003169 Protein of unknown function (DUF2005); Region: DUF2005; pfam09407 478434003170 Uncharacterized conserved protein [Function unknown]; Region: COG2253 478434003171 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4293 478434003172 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 478434003173 Predicted CRISPR-associated polymerase [Defense mechanisms]; Region: COG1353 478434003174 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680 478434003175 CRISPR/Cas system-associated protein Csm2; Region: Csm2_III-A; cd09647 478434003176 CRISPR/Cas system-associated RAMP superfamily protein Csm3; Region: Csm3_III-A; cd09684 478434003177 CRISPR/Cas system-associated RAMP superfamily protein Csm4; Region: Csm4_III-A; cd09663 478434003178 CRISPR/Cas system-associated RAMP superfamily protein Csm5; Region: Csm5_III-A; cd09662 478434003179 CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cd09699 478434003180 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09636 478434003181 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638 478434003182 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 478434003183 Transposase; Region: HTH_Tnp_1; cl17663 478434003184 putative transposase OrfB; Reviewed; Region: PHA02517 478434003185 HTH-like domain; Region: HTH_21; pfam13276 478434003186 Integrase core domain; Region: rve; pfam00665 478434003187 Integrase core domain; Region: rve_3; pfam13683 478434003188 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 478434003189 Helix-turn-helix domain; Region: HTH_28; pfam13518 478434003190 Winged helix-turn helix; Region: HTH_29; pfam13551 478434003191 Integrase core domain; Region: rve; pfam00665 478434003192 Integrase core domain; Region: rve_3; pfam13683 478434003193 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 478434003194 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 478434003195 Transposase; Region: DDE_Tnp_ISL3; pfam01610 478434003196 Integrase core domain; Region: rve; pfam00665 478434003197 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 478434003198 Uncharacterized conserved protein [Function unknown]; Region: COG5586 478434003199 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 478434003200 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 478434003201 Predicted acyl esterases [General function prediction only]; Region: COG2936 478434003202 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 478434003203 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 478434003204 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 478434003205 Uncharacterized conserved protein [Function unknown]; Region: COG4717 478434003206 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 478434003207 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 478434003208 active site 478434003209 metal binding site [ion binding]; metal-binding site 478434003210 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 478434003211 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 478434003212 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 478434003213 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 478434003214 RNA binding site [nucleotide binding]; other site 478434003215 active site 478434003216 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 478434003217 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 478434003218 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 478434003219 catalytic residues [active] 478434003220 catalytic nucleophile [active] 478434003221 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 478434003222 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 478434003223 Probable transposase; Region: OrfB_IS605; pfam01385 478434003224 lipid-transfer protein; Provisional; Region: PRK08256 478434003225 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 478434003226 active site 478434003227 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 478434003228 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 478434003229 active site 478434003230 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 478434003231 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 478434003232 putative DNA binding site [nucleotide binding]; other site 478434003233 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 478434003234 FeoA domain; Region: FeoA; pfam04023 478434003235 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 478434003236 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 478434003237 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 478434003238 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 478434003239 active site 478434003240 Riboflavin kinase; Region: Flavokinase; pfam01687 478434003241 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 478434003242 16S/18S rRNA binding site [nucleotide binding]; other site 478434003243 S13e-L30e interaction site [polypeptide binding]; other site 478434003244 25S rRNA binding site [nucleotide binding]; other site 478434003245 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 478434003246 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 478434003247 oligomer interface [polypeptide binding]; other site 478434003248 RNA binding site [nucleotide binding]; other site 478434003249 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 478434003250 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 478434003251 RNase E interface [polypeptide binding]; other site 478434003252 trimer interface [polypeptide binding]; other site 478434003253 active site 478434003254 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 478434003255 putative nucleic acid binding region [nucleotide binding]; other site 478434003256 G-X-X-G motif; other site 478434003257 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 478434003258 RNA binding site [nucleotide binding]; other site 478434003259 domain interface; other site 478434003260 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 478434003261 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 478434003262 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 478434003263 Nitronate monooxygenase; Region: NMO; pfam03060 478434003264 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 478434003265 FMN binding site [chemical binding]; other site 478434003266 substrate binding site [chemical binding]; other site 478434003267 putative catalytic residue [active] 478434003268 alanine dehydrogenase; Region: alaDH; TIGR00518 478434003269 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 478434003270 hexamer interface [polypeptide binding]; other site 478434003271 ligand binding site [chemical binding]; other site 478434003272 putative active site [active] 478434003273 NAD(P) binding site [chemical binding]; other site 478434003274 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 478434003275 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 478434003276 putative DNA binding site [nucleotide binding]; other site 478434003277 putative Zn2+ binding site [ion binding]; other site 478434003278 AsnC family; Region: AsnC_trans_reg; pfam01037 478434003279 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 478434003280 hydrophobic ligand binding site; other site 478434003281 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 478434003282 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 478434003283 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 478434003284 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 478434003285 FMN-binding pocket [chemical binding]; other site 478434003286 flavin binding motif; other site 478434003287 phosphate binding motif [ion binding]; other site 478434003288 beta-alpha-beta structure motif; other site 478434003289 NAD binding pocket [chemical binding]; other site 478434003290 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 478434003291 catalytic loop [active] 478434003292 iron binding site [ion binding]; other site 478434003293 putative transposase OrfB; Reviewed; Region: PHA02517 478434003294 HTH-like domain; Region: HTH_21; pfam13276 478434003295 Integrase core domain; Region: rve; pfam00665 478434003296 Integrase core domain; Region: rve_3; pfam13683 478434003297 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 478434003298 Transposase; Region: HTH_Tnp_1; cl17663 478434003299 dihydrodipicolinate reductase; Provisional; Region: PRK00048 478434003300 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 478434003301 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 478434003302 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 478434003303 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478434003304 PPE family; Region: PPE; pfam00823 478434003305 PE family; Region: PE; pfam00934 478434003306 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 478434003307 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478434003308 PPE family; Region: PPE; pfam00823 478434003309 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 478434003310 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 478434003311 classical (c) SDRs; Region: SDR_c; cd05233 478434003312 NAD(P) binding site [chemical binding]; other site 478434003313 active site 478434003314 Dienelactone hydrolase family; Region: DLH; pfam01738 478434003315 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 478434003316 thymidylate synthase; Reviewed; Region: thyA; PRK01827 478434003317 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 478434003318 dimerization interface [polypeptide binding]; other site 478434003319 active site 478434003320 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 478434003321 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 478434003322 folate binding site [chemical binding]; other site 478434003323 NADP+ binding site [chemical binding]; other site 478434003324 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 478434003325 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 478434003326 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 478434003327 Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704 478434003328 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 478434003329 putative active site [active] 478434003330 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 478434003331 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 478434003332 putative active site [active] 478434003333 HsdM N-terminal domain; Region: HsdM_N; pfam12161 478434003334 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 478434003335 Methyltransferase domain; Region: Methyltransf_26; pfam13659 478434003336 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 478434003337 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 478434003338 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 478434003339 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 478434003340 dimer interface [polypeptide binding]; other site 478434003341 active site 478434003342 catalytic residue [active] 478434003343 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 478434003344 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 478434003345 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 478434003346 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 478434003347 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 478434003348 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 478434003349 classical (c) SDRs; Region: SDR_c; cd05233 478434003350 NAD(P) binding site [chemical binding]; other site 478434003351 active site 478434003352 Uncharacterized conserved protein [Function unknown]; Region: COG1359 478434003353 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 478434003354 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 478434003355 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 478434003356 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 478434003357 Coenzyme A binding pocket [chemical binding]; other site 478434003358 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 478434003359 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 478434003360 non-specific DNA binding site [nucleotide binding]; other site 478434003361 salt bridge; other site 478434003362 sequence-specific DNA binding site [nucleotide binding]; other site 478434003363 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 478434003364 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 478434003365 PE family; Region: PE; pfam00934 478434003366 Limonene-1,2-epoxide hydrolase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LimA; COG4308 478434003367 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 478434003368 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 478434003369 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 478434003370 DNA recombination protein RecA; Reviewed; Region: recA; PRK09519 478434003371 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 478434003372 hexamer interface [polypeptide binding]; other site 478434003373 Walker A motif; other site 478434003374 ATP binding site [chemical binding]; other site 478434003375 Walker B motif; other site 478434003376 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 478434003377 protein-splicing catalytic site; other site 478434003378 thioester formation/cholesterol transfer; other site 478434003379 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 478434003380 recA bacterial DNA recombination protein; Region: RecA; cl17211 478434003381 Uncharacterized protein conserved in bacteria [General function prediction only]; Region: OraA; COG2137 478434003382 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 478434003383 FeS/SAM binding site; other site 478434003384 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 478434003385 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 478434003386 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 478434003387 FeS/SAM binding site; other site 478434003388 TRAM domain; Region: TRAM; cl01282 478434003389 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 478434003390 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 478434003391 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 478434003392 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 478434003393 active site 478434003394 metal binding site [ion binding]; metal-binding site 478434003395 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 478434003396 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 478434003397 diaminopimelate epimerase; Region: DapF; TIGR00652 478434003398 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 478434003399 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 478434003400 GTPases [General function prediction only]; Region: HflX; COG2262 478434003401 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 478434003402 HflX GTPase family; Region: HflX; cd01878 478434003403 G1 box; other site 478434003404 GTP/Mg2+ binding site [chemical binding]; other site 478434003405 Switch I region; other site 478434003406 G2 box; other site 478434003407 G3 box; other site 478434003408 Switch II region; other site 478434003409 G4 box; other site 478434003410 G5 box; other site 478434003411 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 478434003412 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 478434003413 active site 478434003414 Integral membrane protein TerC family; Region: TerC; cl10468 478434003415 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 478434003416 LGFP repeat; Region: LGFP; pfam08310 478434003417 LGFP repeat; Region: LGFP; pfam08310 478434003418 LGFP repeat; Region: LGFP; pfam08310 478434003419 LGFP repeat; Region: LGFP; pfam08310 478434003420 LGFP repeat; Region: LGFP; pfam08310 478434003421 LexA repressor; Validated; Region: PRK00215 478434003422 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 478434003423 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 478434003424 Catalytic site [active] 478434003425 LysM domain; Region: LysM; pfam01476 478434003426 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 478434003427 ATP cone domain; Region: ATP-cone; pfam03477 478434003428 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 478434003429 heme-binding site [chemical binding]; other site 478434003430 Phenazine biosynthesis-like protein; Region: PhzC-PhzF; pfam02567 478434003431 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 478434003432 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 478434003433 PAC2 family; Region: PAC2; pfam09754 478434003434 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 478434003435 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 478434003436 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 478434003437 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 478434003438 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 478434003439 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 478434003440 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 478434003441 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 478434003442 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 478434003443 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 478434003444 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 478434003445 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 478434003446 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 478434003447 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 478434003448 DNA binding residues [nucleotide binding] 478434003449 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 478434003450 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 478434003451 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 478434003452 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3502 478434003453 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 478434003454 homotrimer interaction site [polypeptide binding]; other site 478434003455 putative active site [active] 478434003456 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 478434003457 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 478434003458 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 478434003459 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 478434003460 DNA binding residues [nucleotide binding] 478434003461 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 478434003462 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 478434003463 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 478434003464 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 478434003465 active site 478434003466 dimerization interface [polypeptide binding]; other site 478434003467 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 478434003468 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 478434003469 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 478434003470 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 478434003471 trimer interface [polypeptide binding]; other site 478434003472 active site 478434003473 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 478434003474 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 478434003475 generic binding surface II; other site 478434003476 ssDNA binding site; other site 478434003477 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 478434003478 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 478434003479 TrkA-N domain; Region: TrkA_N; pfam02254 478434003480 TrkA-C domain; Region: TrkA_C; pfam02080 478434003481 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 478434003482 TrkA-N domain; Region: TrkA_N; pfam02254 478434003483 TrkA-C domain; Region: TrkA_C; pfam02080 478434003484 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 478434003485 TRAM domain; Region: TRAM; cl01282 478434003486 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 478434003487 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 478434003488 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 478434003489 Walker A/P-loop; other site 478434003490 ATP binding site [chemical binding]; other site 478434003491 Q-loop/lid; other site 478434003492 ABC transporter signature motif; other site 478434003493 Walker B; other site 478434003494 D-loop; other site 478434003495 H-loop/switch region; other site 478434003496 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 478434003497 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 478434003498 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 478434003499 transmembrane helices; other site 478434003500 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 478434003501 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 478434003502 transmembrane helices; other site 478434003503 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 478434003504 Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154 478434003505 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 478434003506 TPP-binding site; other site 478434003507 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 478434003508 PYR/PP interface [polypeptide binding]; other site 478434003509 dimer interface [polypeptide binding]; other site 478434003510 TPP binding site [chemical binding]; other site 478434003511 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 478434003512 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 478434003513 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 478434003514 catalytic site [active] 478434003515 putative active site [active] 478434003516 putative substrate binding site [chemical binding]; other site 478434003517 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 478434003518 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 478434003519 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 478434003520 substrate binding site [chemical binding]; other site 478434003521 oxyanion hole (OAH) forming residues; other site 478434003522 trimer interface [polypeptide binding]; other site 478434003523 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 478434003524 substrate binding site [chemical binding]; other site 478434003525 active site 478434003526 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 478434003527 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 478434003528 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 478434003529 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 478434003530 Methyltransferase domain; Region: Methyltransf_31; pfam13847 478434003531 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478434003532 S-adenosylmethionine binding site [chemical binding]; other site 478434003533 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 478434003534 SelR domain; Region: SelR; pfam01641 478434003535 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 478434003536 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 478434003537 TAP-like protein; Region: Abhydrolase_4; pfam08386 478434003538 hypothetical protein; Provisional; Region: PRK14059 478434003539 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 478434003540 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 478434003541 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 478434003542 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 478434003543 Coenzyme A binding pocket [chemical binding]; other site 478434003544 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 478434003545 Transposase, Mutator family; Region: Transposase_mut; pfam00872 478434003546 MULE transposase domain; Region: MULE; pfam10551 478434003547 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 478434003548 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 478434003549 active site 478434003550 catalytic residues [active] 478434003551 DNA binding site [nucleotide binding] 478434003552 Int/Topo IB signature motif; other site 478434003553 DNA binding domain, excisionase family; Region: excise; TIGR01764 478434003554 Protein of unknown function (DUF2742); Region: DUF2742; pfam10888 478434003555 Protein of unknown function (DUF3631); Region: DUF3631; pfam12307 478434003556 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: COG3747 478434003557 Phage head maturation protease [General function prediction only]; Region: COG3740 478434003558 Predicted phage phi-C31 gp36 major capsid-like protein [General function prediction only]; Region: COG4653 478434003559 Phage capsid family; Region: Phage_capsid; pfam05065 478434003560 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 478434003561 ParB-like nuclease domain; Region: ParBc; cl02129 478434003562 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 478434003563 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 478434003564 active site 478434003565 DNA binding site [nucleotide binding] 478434003566 Int/Topo IB signature motif; other site 478434003567 Protein of unknown function (DUF3018); Region: DUF3018; pfam11455 478434003568 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 478434003569 arsenical-resistance protein; Region: acr3; TIGR00832 478434003570 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 478434003571 Low molecular weight phosphatase family; Region: LMWPc; cd00115 478434003572 active site 478434003573 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 478434003574 dimerization interface [polypeptide binding]; other site 478434003575 putative DNA binding site [nucleotide binding]; other site 478434003576 putative Zn2+ binding site [ion binding]; other site 478434003577 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 478434003578 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 478434003579 putative metal binding site [ion binding]; other site 478434003580 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 478434003581 Transcriptional regulators [Transcription]; Region: MarR; COG1846 478434003582 putative DNA binding site [nucleotide binding]; other site 478434003583 putative Zn2+ binding site [ion binding]; other site 478434003584 hypothetical protein; Provisional; Region: PRK02237 478434003585 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 478434003586 anti sigma factor interaction site; other site 478434003587 regulatory phosphorylation site [posttranslational modification]; other site 478434003588 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 478434003589 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 478434003590 Chloramphenicol (Cm) phosphotransferase (CPT). Cm-inactivating enzyme; modifies the primary (C-3) hydroxyl of the antibiotic. Related structurally to shikimate kinase II; Region: CPT; cd00227 478434003591 P-loop motif; other site 478434003592 ATP binding site [chemical binding]; other site 478434003593 Chloramphenicol (Cm) binding site [chemical binding]; other site 478434003594 catalytic residue [active] 478434003595 PE family; Region: PE; pfam00934 478434003596 Hemerythrin-like domain; Region: Hr-like; cd12108 478434003597 Fe binding site [ion binding]; other site 478434003598 Domain of unknown function (DUF1876); Region: DUF1876; pfam08962 478434003599 Uncharacterized conserved protein [Function unknown]; Region: RtcB; COG1690 478434003600 hypothetical protein; Reviewed; Region: PRK09588 478434003601 SHS2 domain protein implicated in nucleic acid metabolism [General function prediction only]; Region: COG1371 478434003602 peptide chain release factor 1; Provisional; Region: PRK04011 478434003603 FOG: CBS domain [General function prediction only]; Region: COG0517 478434003604 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 478434003605 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 478434003606 active site 478434003607 Peptidase family M50; Region: Peptidase_M50; pfam02163 478434003608 putative substrate binding region [chemical binding]; other site 478434003609 FOG: CBS domain [General function prediction only]; Region: COG0517 478434003610 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612 478434003611 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 478434003612 Ligand Binding Site [chemical binding]; other site 478434003613 Universal stress protein family; Region: Usp; pfam00582 478434003614 Ligand Binding Site [chemical binding]; other site 478434003615 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 478434003616 Ligand Binding Site [chemical binding]; other site 478434003617 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 478434003618 Ligand Binding Site [chemical binding]; other site 478434003619 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478434003620 S-adenosylmethionine binding site [chemical binding]; other site 478434003621 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 478434003622 Predicted transcriptional regulator [Transcription]; Region: COG2345 478434003623 Helix-turn-helix domain; Region: HTH_20; pfam12840 478434003624 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 478434003625 Helix-turn-helix domain; Region: HTH_20; pfam12840 478434003626 Predicted transcriptional regulator [Transcription]; Region: COG2345 478434003627 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4762 478434003628 PE family; Region: PE; pfam00934 478434003629 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 478434003630 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 478434003631 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 478434003632 active site 478434003633 dimer interface [polypeptide binding]; other site 478434003634 motif 1; other site 478434003635 motif 2; other site 478434003636 motif 3; other site 478434003637 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 478434003638 anticodon binding site; other site 478434003639 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 478434003640 nucleotide binding site/active site [active] 478434003641 HIT family signature motif; other site 478434003642 catalytic residue [active] 478434003643 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 478434003644 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 478434003645 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 478434003646 putative acyl-acceptor binding pocket; other site 478434003647 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 478434003648 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 478434003649 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_26; cd04685 478434003650 nudix motif; other site 478434003651 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478434003652 PPE family; Region: PPE; pfam00823 478434003653 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478434003654 PE-PPE domain; Region: PE-PPE; pfam08237 478434003655 Pyridoxamine-phosphate oxidase [Coenzyme metabolism]; Region: PdxH; COG0259 478434003656 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 478434003657 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 478434003658 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 478434003659 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 478434003660 active site 478434003661 multimer interface [polypeptide binding]; other site 478434003662 acyl-CoA thioesterase II; Region: tesB; TIGR00189 478434003663 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 478434003664 active site 478434003665 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 478434003666 catalytic triad [active] 478434003667 dimer interface [polypeptide binding]; other site 478434003668 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 478434003669 predicted active site [active] 478434003670 catalytic triad [active] 478434003671 hypothetical protein; Validated; Region: PRK00110 478434003672 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 478434003673 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 478434003674 Predicted spermidine synthase with an N-terminal membrane domain [General function prediction only]; Region: COG4262 478434003675 Spermine/spermidine synthase; Region: Spermine_synth; pfam01564 478434003676 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 478434003677 Domain of unknown function (DUF4247); Region: DUF4247; pfam14042 478434003678 Protein of unknown function DUF2617; Region: DUF2617; pfam10936 478434003679 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 478434003680 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 478434003681 putative active site [active] 478434003682 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 478434003683 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 478434003684 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 478434003685 active site 478434003686 putative DNA-binding cleft [nucleotide binding]; other site 478434003687 dimer interface [polypeptide binding]; other site 478434003688 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 478434003689 RuvA N terminal domain; Region: RuvA_N; pfam01330 478434003690 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 478434003691 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 478434003692 Walker A motif; other site 478434003693 ATP binding site [chemical binding]; other site 478434003694 Walker B motif; other site 478434003695 arginine finger; other site 478434003696 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 478434003697 PE family; Region: PE; pfam00934 478434003698 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 478434003699 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 478434003700 acyl-activating enzyme (AAE) consensus motif; other site 478434003701 AMP binding site [chemical binding]; other site 478434003702 active site 478434003703 CoA binding site [chemical binding]; other site 478434003704 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 478434003705 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 478434003706 putative NAD(P) binding site [chemical binding]; other site 478434003707 active site 478434003708 putative substrate binding site [chemical binding]; other site 478434003709 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 478434003710 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 478434003711 inhibitor-cofactor binding pocket; inhibition site 478434003712 pyridoxal 5'-phosphate binding site [chemical binding]; other site 478434003713 catalytic residue [active] 478434003714 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05886 478434003715 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 478434003716 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 478434003717 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 478434003718 Protein export membrane protein; Region: SecD_SecF; pfam02355 478434003719 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 478434003720 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 478434003721 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 478434003722 active site 478434003723 (p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691 478434003724 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 478434003725 Zn2+ binding site [ion binding]; other site 478434003726 Mg2+ binding site [ion binding]; other site 478434003727 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 478434003728 synthetase active site [active] 478434003729 NTP binding site [chemical binding]; other site 478434003730 metal binding site [ion binding]; metal-binding site 478434003731 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 478434003732 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 478434003733 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 478434003734 active site 478434003735 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 478434003736 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 478434003737 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 478434003738 dimer interface [polypeptide binding]; other site 478434003739 motif 1; other site 478434003740 active site 478434003741 motif 2; other site 478434003742 motif 3; other site 478434003743 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 478434003744 anticodon binding site; other site 478434003745 haloalkane dehalogenase; Provisional; Region: PRK03592 478434003746 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 478434003747 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 478434003748 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 478434003749 active site 478434003750 metal binding site [ion binding]; metal-binding site 478434003751 Predicted metalloprotease [General function prediction only]; Region: COG2321 478434003752 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 478434003753 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 478434003754 putative hydrophobic ligand binding site [chemical binding]; other site 478434003755 protein interface [polypeptide binding]; other site 478434003756 gate; other site 478434003757 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 478434003758 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 478434003759 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 478434003760 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 478434003761 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 478434003762 dimer interface [polypeptide binding]; other site 478434003763 anticodon binding site; other site 478434003764 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 478434003765 homodimer interface [polypeptide binding]; other site 478434003766 motif 1; other site 478434003767 active site 478434003768 motif 2; other site 478434003769 GAD domain; Region: GAD; pfam02938 478434003770 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 478434003771 active site 478434003772 motif 3; other site 478434003773 Predicted membrane protein [Function unknown]; Region: COG4129 478434003774 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 478434003775 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3801 478434003776 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 478434003777 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 478434003778 Transglutaminase/protease-like homologues; Region: TGc; smart00460 478434003779 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307 478434003780 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 478434003781 Uncharacterized conserved protein [Function unknown]; Region: COG2308 478434003782 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 478434003783 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 478434003784 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 478434003785 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 478434003786 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 478434003787 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 478434003788 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 478434003789 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 478434003790 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 478434003791 ligand binding site [chemical binding]; other site 478434003792 flexible hinge region; other site 478434003793 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 478434003794 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 478434003795 active site 478434003796 nucleophile elbow; other site 478434003797 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 478434003798 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 478434003799 Walker A/P-loop; other site 478434003800 ATP binding site [chemical binding]; other site 478434003801 Q-loop/lid; other site 478434003802 ABC transporter signature motif; other site 478434003803 Walker B; other site 478434003804 D-loop; other site 478434003805 H-loop/switch region; other site 478434003806 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 478434003807 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 478434003808 ligand binding site [chemical binding]; other site 478434003809 flexible hinge region; other site 478434003810 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 478434003811 Protein of unknown function (DUF2652); Region: DUF2652; pfam10851 478434003812 Predicted integral membrane protein [Function unknown]; Region: COG5473 478434003813 recombination factor protein RarA; Reviewed; Region: PRK13342 478434003814 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 478434003815 Walker A motif; other site 478434003816 ATP binding site [chemical binding]; other site 478434003817 Walker B motif; other site 478434003818 arginine finger; other site 478434003819 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 478434003820 Uncharacterized conserved protein [Function unknown]; Region: COG0432 478434003821 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 478434003822 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 478434003823 motif 1; other site 478434003824 active site 478434003825 motif 2; other site 478434003826 motif 3; other site 478434003827 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 478434003828 DHHA1 domain; Region: DHHA1; pfam02272 478434003829 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 478434003830 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 478434003831 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 478434003832 dimerization interface [polypeptide binding]; other site 478434003833 shikimate-5-dehydrogenase, fungal AROM-type; Region: Shik-DH-AROM; TIGR01809 478434003834 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 478434003835 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 478434003836 NAD(P) binding site [chemical binding]; other site 478434003837 shikimate binding site; other site 478434003838 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 478434003839 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 478434003840 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 478434003841 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2402 478434003842 putative active site [active] 478434003843 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 478434003844 oligomeric interface; other site 478434003845 putative active site [active] 478434003846 homodimer interface [polypeptide binding]; other site 478434003847 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 478434003848 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 478434003849 putative active site [active] 478434003850 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 478434003851 digalactosyldiacylglycerol synthase; Region: PLN02846 478434003852 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 478434003853 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 478434003854 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 478434003855 Tetramer interface [polypeptide binding]; other site 478434003856 active site 478434003857 FMN-binding site [chemical binding]; other site 478434003858 shikimate kinase; Reviewed; Region: aroK; PRK00131 478434003859 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 478434003860 ADP binding site [chemical binding]; other site 478434003861 magnesium binding site [ion binding]; other site 478434003862 putative shikimate binding site; other site 478434003863 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 478434003864 active site 478434003865 dimer interface [polypeptide binding]; other site 478434003866 metal binding site [ion binding]; metal-binding site 478434003867 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 478434003868 Dehydroquinase class II; Region: DHquinase_II; pfam01220 478434003869 trimer interface [polypeptide binding]; other site 478434003870 active site 478434003871 dimer interface [polypeptide binding]; other site 478434003872 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 478434003873 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 478434003874 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 478434003875 active site 478434003876 elongation factor P; Validated; Region: PRK00529 478434003877 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 478434003878 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 478434003879 RNA binding site [nucleotide binding]; other site 478434003880 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 478434003881 RNA binding site [nucleotide binding]; other site 478434003882 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 478434003883 putative RNA binding site [nucleotide binding]; other site 478434003884 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 478434003885 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 478434003886 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 478434003887 catalytic residue [active] 478434003888 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 478434003889 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 478434003890 putative active site [active] 478434003891 ERCC4 domain; Region: ERCC4; pfam02732 478434003892 Lsr2; Region: Lsr2; pfam11774 478434003893 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 478434003894 Mrr N-terminal domain; Region: Mrr_N; pfam14338 478434003895 Restriction endonuclease; Region: Mrr_cat; pfam04471 478434003896 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 478434003897 putative active site [active] 478434003898 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 478434003899 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 478434003900 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 478434003901 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 478434003902 phosphate binding site [ion binding]; other site 478434003903 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 478434003904 FAS_MaoC, the MaoC-like hot dog fold of the fatty acid synthase, beta subunit. Other enzymes with this fold include MaoC dehydratase, Hydratase-Dehydrogenase-Epimerase protein (HDE), and 17-beta-hydroxysteriod dehydrogenase (HSD); Region: FAS_MaoC; cd03447 478434003905 putative active site [active] 478434003906 putative catalytic site [active] 478434003907 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 478434003908 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 478434003909 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 478434003910 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 478434003911 putative NAD(P) binding site [chemical binding]; other site 478434003912 active site 478434003913 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 478434003914 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 478434003915 active site 478434003916 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 478434003917 hypothetical protein; Provisional; Region: PRK07907 478434003918 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 478434003919 active site 478434003920 metal binding site [ion binding]; metal-binding site 478434003921 dimer interface [polypeptide binding]; other site 478434003922 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 478434003923 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 478434003924 catalytic triad [active] 478434003925 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 478434003926 PE family; Region: PE; pfam00934 478434003927 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 478434003928 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 478434003929 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 478434003930 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 478434003931 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2739; cl17893 478434003932 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 478434003933 non-specific DNA binding site [nucleotide binding]; other site 478434003934 salt bridge; other site 478434003935 sequence-specific DNA binding site [nucleotide binding]; other site 478434003936 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 478434003937 Domain of unknown function (DUF4411); Region: DUF4411; pfam14367 478434003938 Transposase, Mutator family; Region: Transposase_mut; pfam00872 478434003939 MULE transposase domain; Region: MULE; pfam10551 478434003940 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 478434003941 catalytic site [active] 478434003942 putative active site [active] 478434003943 putative substrate binding site [chemical binding]; other site 478434003944 dimer interface [polypeptide binding]; other site 478434003945 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 478434003946 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 478434003947 classical (c) SDRs; Region: SDR_c; cd05233 478434003948 NAD(P) binding site [chemical binding]; other site 478434003949 active site 478434003950 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 478434003951 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 478434003952 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478434003953 AMP-binding domain protein; Validated; Region: PRK08315 478434003954 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 478434003955 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 478434003956 acyl-activating enzyme (AAE) consensus motif; other site 478434003957 acyl-activating enzyme (AAE) consensus motif; other site 478434003958 putative AMP binding site [chemical binding]; other site 478434003959 putative active site [active] 478434003960 putative CoA binding site [chemical binding]; other site 478434003961 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 478434003962 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 478434003963 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 478434003964 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 478434003965 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 478434003966 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 478434003967 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 478434003968 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 478434003969 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 478434003970 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 478434003971 carboxyltransferase (CT) interaction site; other site 478434003972 biotinylation site [posttranslational modification]; other site 478434003973 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 478434003974 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 478434003975 active site 478434003976 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 478434003977 putative active site [active] 478434003978 putative catalytic site [active] 478434003979 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 478434003980 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 478434003981 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 478434003982 tetramer interface [polypeptide binding]; other site 478434003983 TPP-binding site [chemical binding]; other site 478434003984 heterodimer interface [polypeptide binding]; other site 478434003985 phosphorylation loop region [posttranslational modification] 478434003986 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 478434003987 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 478434003988 alpha subunit interface [polypeptide binding]; other site 478434003989 TPP binding site [chemical binding]; other site 478434003990 heterodimer interface [polypeptide binding]; other site 478434003991 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 478434003992 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 478434003993 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 478434003994 E3 interaction surface; other site 478434003995 lipoyl attachment site [posttranslational modification]; other site 478434003996 e3 binding domain; Region: E3_binding; pfam02817 478434003997 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 478434003998 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 478434003999 putative transposase OrfB; Reviewed; Region: PHA02517 478434004000 HTH-like domain; Region: HTH_21; pfam13276 478434004001 Integrase core domain; Region: rve; pfam00665 478434004002 Integrase core domain; Region: rve_3; pfam13683 478434004003 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 478434004004 Transposase; Region: HTH_Tnp_1; cl17663 478434004005 TIGR00725 family protein; Region: TIGR00725 478434004006 PE family; Region: PE; pfam00934 478434004007 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 478434004008 cyclase homology domain; Region: CHD; cd07302 478434004009 nucleotidyl binding site; other site 478434004010 metal binding site [ion binding]; metal-binding site 478434004011 dimer interface [polypeptide binding]; other site 478434004012 Predicted ATPase [General function prediction only]; Region: COG3903 478434004013 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 478434004014 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 478434004015 DNA binding residues [nucleotide binding] 478434004016 dimerization interface [polypeptide binding]; other site 478434004017 PE family; Region: PE; pfam00934 478434004018 enoyl-CoA hydratase; Provisional; Region: PRK05870 478434004019 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 478434004020 substrate binding site [chemical binding]; other site 478434004021 oxyanion hole (OAH) forming residues; other site 478434004022 trimer interface [polypeptide binding]; other site 478434004023 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 478434004024 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 478434004025 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 478434004026 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 478434004027 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 478434004028 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 478434004029 HAD-superfamily subfamily IB hydrolase, TIGR01490; Region: HAD-SF-IB-hyp1 478434004030 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 478434004031 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 478434004032 putative acyl-acceptor binding pocket; other site 478434004033 glycerol-3-phosphate acyltransferase; Validated; Region: PRK03355 478434004034 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 478434004035 putative acyl-acceptor binding pocket; other site 478434004036 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 478434004037 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 478434004038 dimer interface [polypeptide binding]; other site 478434004039 ssDNA binding site [nucleotide binding]; other site 478434004040 tetramer (dimer of dimers) interface [polypeptide binding]; other site 478434004041 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 478434004042 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 478434004043 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 478434004044 ABC transporter; Region: ABC_tran_2; pfam12848 478434004045 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 478434004046 NAD-specific glutamate dehydrogenase [Amino acid transport and metabolism]; Region: COG2902 478434004047 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 478434004048 active site 478434004049 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 478434004050 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 478434004051 active site 478434004052 catalytic site [active] 478434004053 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 478434004054 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 478434004055 apolar tunnel; other site 478434004056 heme binding site [chemical binding]; other site 478434004057 dimerization interface [polypeptide binding]; other site 478434004058 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 478434004059 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 478434004060 active site 478434004061 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 478434004062 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 478434004063 Zn binding site [ion binding]; other site 478434004064 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 478434004065 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 478434004066 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 478434004067 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 478434004068 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 478434004069 putative DNA binding site [nucleotide binding]; other site 478434004070 catalytic residue [active] 478434004071 putative H2TH interface [polypeptide binding]; other site 478434004072 putative catalytic residues [active] 478434004073 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 478434004074 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 478434004075 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 478434004076 Beta-lactamase; Region: Beta-lactamase; pfam00144 478434004077 trigger factor; Provisional; Region: tig; PRK01490 478434004078 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 478434004079 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 478434004080 Clp protease; Region: CLP_protease; pfam00574 478434004081 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 478434004082 oligomer interface [polypeptide binding]; other site 478434004083 active site residues [active] 478434004084 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 478434004085 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 478434004086 oligomer interface [polypeptide binding]; other site 478434004087 active site residues [active] 478434004088 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 478434004089 Major Facilitator Superfamily; Region: MFS_1; pfam07690 478434004090 putative substrate translocation pore; other site 478434004091 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 478434004092 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 478434004093 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 478434004094 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 478434004095 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 478434004096 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 478434004097 Walker A motif; other site 478434004098 ATP binding site [chemical binding]; other site 478434004099 Walker B motif; other site 478434004100 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 478434004101 Major Facilitator Superfamily; Region: MFS_1; pfam07690 478434004102 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 478434004103 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 478434004104 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 478434004105 dimer interface [polypeptide binding]; other site 478434004106 PYR/PP interface [polypeptide binding]; other site 478434004107 TPP binding site [chemical binding]; other site 478434004108 substrate binding site [chemical binding]; other site 478434004109 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 478434004110 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 478434004111 TPP-binding site [chemical binding]; other site 478434004112 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 478434004113 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 478434004114 GTP binding site; other site 478434004115 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 478434004116 Uncharacterized conserved protein [Function unknown]; Region: COG3268 478434004117 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 478434004118 NAD(P) binding pocket [chemical binding]; other site 478434004119 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 478434004120 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 478434004121 active site 478434004122 HIGH motif; other site 478434004123 nucleotide binding site [chemical binding]; other site 478434004124 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 478434004125 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 478434004126 active site 478434004127 KMSKS motif; other site 478434004128 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 478434004129 tRNA binding surface [nucleotide binding]; other site 478434004130 anticodon binding site; other site 478434004131 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 478434004132 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 478434004133 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 478434004134 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 478434004135 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 478434004136 active site 478434004137 multimer interface [polypeptide binding]; other site 478434004138 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 478434004139 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 478434004140 homodimer interface [polypeptide binding]; other site 478434004141 oligonucleotide binding site [chemical binding]; other site 478434004142 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 478434004143 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 478434004144 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 478434004145 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 478434004146 GTPase CgtA; Reviewed; Region: obgE; PRK12296 478434004147 GTP1/OBG; Region: GTP1_OBG; pfam01018 478434004148 Obg GTPase; Region: Obg; cd01898 478434004149 G1 box; other site 478434004150 GTP/Mg2+ binding site [chemical binding]; other site 478434004151 Switch I region; other site 478434004152 G2 box; other site 478434004153 G3 box; other site 478434004154 Switch II region; other site 478434004155 G4 box; other site 478434004156 G5 box; other site 478434004157 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 478434004158 gamma-glutamyl kinase; Provisional; Region: PRK05429 478434004159 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 478434004160 nucleotide binding site [chemical binding]; other site 478434004161 homotetrameric interface [polypeptide binding]; other site 478434004162 putative phosphate binding site [ion binding]; other site 478434004163 putative allosteric binding site; other site 478434004164 PUA domain; Region: PUA; pfam01472 478434004165 NAD synthetase; Reviewed; Region: nadE; PRK02628 478434004166 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 478434004167 multimer interface [polypeptide binding]; other site 478434004168 active site 478434004169 catalytic triad [active] 478434004170 protein interface 1 [polypeptide binding]; other site 478434004171 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 478434004172 homodimer interface [polypeptide binding]; other site 478434004173 NAD binding pocket [chemical binding]; other site 478434004174 ATP binding pocket [chemical binding]; other site 478434004175 Mg binding site [ion binding]; other site 478434004176 active-site loop [active] 478434004177 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 478434004178 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 478434004179 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 478434004180 substrate binding site [chemical binding]; other site 478434004181 dimer interface [polypeptide binding]; other site 478434004182 ATP binding site [chemical binding]; other site 478434004183 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 478434004184 dimerization interface [polypeptide binding]; other site 478434004185 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 478434004186 cyclase homology domain; Region: CHD; cd07302 478434004187 nucleotidyl binding site; other site 478434004188 metal binding site [ion binding]; metal-binding site 478434004189 dimer interface [polypeptide binding]; other site 478434004190 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 478434004191 Mechanosensitive ion channel; Region: MS_channel; pfam00924 478434004192 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 478434004193 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 478434004194 ligand binding site [chemical binding]; other site 478434004195 flexible hinge region; other site 478434004196 PE family; Region: PE; pfam00934 478434004197 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478434004198 PPE family; Region: PPE; pfam00823 478434004199 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 478434004200 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 478434004201 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 478434004202 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 478434004203 dimer interface [polypeptide binding]; other site 478434004204 decamer (pentamer of dimers) interface [polypeptide binding]; other site 478434004205 catalytic triad [active] 478434004206 peroxidatic and resolving cysteines [active] 478434004207 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 478434004208 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 478434004209 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 478434004210 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 478434004211 putative catalytic cysteine [active] 478434004212 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 478434004213 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 478434004214 Walker A motif; other site 478434004215 ATP binding site [chemical binding]; other site 478434004216 Walker B motif; other site 478434004217 arginine finger; other site 478434004218 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 478434004219 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 478434004220 metal ion-dependent adhesion site (MIDAS); other site 478434004221 Transposase; Region: DEDD_Tnp_IS110; pfam01548 478434004222 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 478434004223 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 478434004224 Methyltransferase domain; Region: Methyltransf_23; pfam13489 478434004225 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478434004226 S-adenosylmethionine binding site [chemical binding]; other site 478434004227 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 478434004228 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 478434004229 active site 478434004230 (T/H)XGH motif; other site 478434004231 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 478434004232 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 478434004233 catalytic core [active] 478434004234 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 478434004235 active site 478434004236 catalytic triad [active] 478434004237 oxyanion hole [active] 478434004238 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307 478434004239 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 478434004240 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 478434004241 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 478434004242 Coenzyme A binding pocket [chemical binding]; other site 478434004243 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 478434004244 Helix-hairpin-helix motif; Region: HHH; pfam00633 478434004245 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 478434004246 Competence protein; Region: Competence; pfam03772 478434004247 hypothetical protein; Reviewed; Region: PRK07914 478434004248 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 478434004249 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 478434004250 Uncharacterized conserved protein [Function unknown]; Region: COG2308 478434004251 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 478434004252 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 478434004253 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 478434004254 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 478434004255 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 478434004256 PE family; Region: PE; pfam00934 478434004257 ribonuclease Z; Reviewed; Region: PRK00055 478434004258 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 478434004259 FOG: CBS domain [General function prediction only]; Region: COG0517 478434004260 PemK-like protein; Region: PemK; pfam02452 478434004261 GTP-binding protein LepA; Provisional; Region: PRK05433 478434004262 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 478434004263 G1 box; other site 478434004264 putative GEF interaction site [polypeptide binding]; other site 478434004265 GTP/Mg2+ binding site [chemical binding]; other site 478434004266 Switch I region; other site 478434004267 G2 box; other site 478434004268 G3 box; other site 478434004269 Switch II region; other site 478434004270 G4 box; other site 478434004271 G5 box; other site 478434004272 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 478434004273 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 478434004274 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 478434004275 PknH-like extracellular domain; Region: PknH_C; pfam14032 478434004276 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 478434004277 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 478434004278 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 478434004279 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 478434004280 sulfate transport protein; Provisional; Region: cysT; CHL00187 478434004281 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 478434004282 dimer interface [polypeptide binding]; other site 478434004283 conserved gate region; other site 478434004284 putative PBP binding loops; other site 478434004285 ABC-ATPase subunit interface; other site 478434004286 sulfate transport protein; Provisional; Region: cysT; CHL00187 478434004287 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 478434004288 dimer interface [polypeptide binding]; other site 478434004289 conserved gate region; other site 478434004290 putative PBP binding loops; other site 478434004291 ABC-ATPase subunit interface; other site 478434004292 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 478434004293 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 478434004294 Walker A/P-loop; other site 478434004295 ATP binding site [chemical binding]; other site 478434004296 Q-loop/lid; other site 478434004297 ABC transporter signature motif; other site 478434004298 Walker B; other site 478434004299 D-loop; other site 478434004300 H-loop/switch region; other site 478434004301 PE family; Region: PE; pfam00934 478434004302 Predicted membrane protein [Function unknown]; Region: COG1297 478434004303 putative oligopeptide transporter, OPT family; Region: TIGR00733 478434004304 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 478434004305 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 478434004306 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 478434004307 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 478434004308 putative active site [active] 478434004309 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 478434004310 putative active site [active] 478434004311 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 478434004312 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 478434004313 Active Sites [active] 478434004314 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 478434004315 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 478434004316 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 478434004317 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 478434004318 coproporphyrinogen III oxidase; Validated; Region: PRK05628 478434004319 Predicted permease [General function prediction only]; Region: COG3329 478434004320 salicylate synthase MbtI; Reviewed; Region: PRK07912 478434004321 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 478434004322 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 478434004323 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 478434004324 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 478434004325 acyl-activating enzyme (AAE) consensus motif; other site 478434004326 active site 478434004327 AMP binding site [chemical binding]; other site 478434004328 substrate binding site [chemical binding]; other site 478434004329 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 478434004330 Condensation domain; Region: Condensation; pfam00668 478434004331 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 478434004332 Nonribosomal peptide synthase; Region: NRPS; pfam08415 478434004333 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 478434004334 acyl-activating enzyme (AAE) consensus motif; other site 478434004335 AMP binding site [chemical binding]; other site 478434004336 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 478434004337 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 478434004338 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 478434004339 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 478434004340 active site 478434004341 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 478434004342 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 478434004343 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 478434004344 NADP binding site [chemical binding]; other site 478434004345 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 478434004346 active site 478434004347 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 478434004348 Condensation domain; Region: Condensation; pfam00668 478434004349 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 478434004350 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 478434004351 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 478434004352 acyl-activating enzyme (AAE) consensus motif; other site 478434004353 AMP binding site [chemical binding]; other site 478434004354 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 478434004355 Condensation domain; Region: Condensation; pfam00668 478434004356 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 478434004357 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 478434004358 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 478434004359 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 478434004360 Condensation domain; Region: Condensation; pfam00668 478434004361 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 478434004362 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 478434004363 acyl-activating enzyme (AAE) consensus motif; other site 478434004364 AMP binding site [chemical binding]; other site 478434004365 Condensation domain; Region: Condensation; pfam00668 478434004366 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 478434004367 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 478434004368 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 478434004369 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 478434004370 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 478434004371 chaperone protein DnaJ; Provisional; Region: PRK14278 478434004372 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 478434004373 HSP70 interaction site [polypeptide binding]; other site 478434004374 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 478434004375 Zn binding sites [ion binding]; other site 478434004376 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 478434004377 dimer interface [polypeptide binding]; other site 478434004378 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 478434004379 RNA methyltransferase, RsmE family; Region: TIGR00046 478434004380 PE family; Region: PE; pfam00934 478434004381 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 478434004382 K homology RNA-binding domain; Region: KH; smart00322 478434004383 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 478434004384 PhoH-like protein; Region: PhoH; pfam02562 478434004385 metal-binding heat shock protein; Provisional; Region: PRK00016 478434004386 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 478434004387 Domain of unknown function DUF21; Region: DUF21; pfam01595 478434004388 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 478434004389 Transporter associated domain; Region: CorC_HlyC; smart01091 478434004390 GTPase Era; Reviewed; Region: era; PRK00089 478434004391 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 478434004392 G1 box; other site 478434004393 GTP/Mg2+ binding site [chemical binding]; other site 478434004394 Switch I region; other site 478434004395 G2 box; other site 478434004396 Switch II region; other site 478434004397 G3 box; other site 478434004398 G4 box; other site 478434004399 G5 box; other site 478434004400 KH domain; Region: KH_2; pfam07650 478434004401 amidase; Provisional; Region: PRK06061 478434004402 Amidase; Region: Amidase; pfam01425 478434004403 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 478434004404 Recombination protein O N terminal; Region: RecO_N; pfam11967 478434004405 Recombination protein O C terminal; Region: RecO_C; pfam02565 478434004406 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 478434004407 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 478434004408 catalytic residue [active] 478434004409 putative FPP diphosphate binding site; other site 478434004410 putative FPP binding hydrophobic cleft; other site 478434004411 dimer interface [polypeptide binding]; other site 478434004412 putative IPP diphosphate binding site; other site 478434004413 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 478434004414 metal binding site 2 [ion binding]; metal-binding site 478434004415 putative DNA binding helix; other site 478434004416 metal binding site 1 [ion binding]; metal-binding site 478434004417 dimer interface [polypeptide binding]; other site 478434004418 structural Zn2+ binding site [ion binding]; other site 478434004419 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 478434004420 dimerization interface [polypeptide binding]; other site 478434004421 putative DNA binding site [nucleotide binding]; other site 478434004422 putative Zn2+ binding site [ion binding]; other site 478434004423 glycyl-tRNA synthetase; Provisional; Region: PRK04173 478434004424 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 478434004425 motif 1; other site 478434004426 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 478434004427 active site 478434004428 motif 2; other site 478434004429 motif 3; other site 478434004430 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 478434004431 anticodon binding site; other site 478434004432 PPE family; Region: PPE; pfam00823 478434004433 PPE family; Region: PPE; pfam00823 478434004434 PPE family; Region: PPE; pfam00823 478434004435 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478434004436 PPE family; Region: PPE; pfam00823 478434004437 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478434004438 PPE family; Region: PPE; pfam00823 478434004439 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 478434004440 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 478434004441 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 478434004442 Transposase; Region: HTH_Tnp_1; cl17663 478434004443 putative transposase OrfB; Reviewed; Region: PHA02517 478434004444 HTH-like domain; Region: HTH_21; pfam13276 478434004445 Integrase core domain; Region: rve; pfam00665 478434004446 Integrase core domain; Region: rve_3; pfam13683 478434004447 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478434004448 PPE family; Region: PPE; pfam00823 478434004449 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 478434004450 Phosphoesterase family; Region: Phosphoesterase; pfam04185 478434004451 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 478434004452 Phosphoesterase family; Region: Phosphoesterase; pfam04185 478434004453 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 478434004454 Phosphoesterase family; Region: Phosphoesterase; pfam04185 478434004455 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 478434004456 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 478434004457 Repair protein; Region: Repair_PSII; pfam04536 478434004458 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 478434004459 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 478434004460 Zn2+ binding site [ion binding]; other site 478434004461 Mg2+ binding site [ion binding]; other site 478434004462 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 478434004463 DNA primase; Validated; Region: dnaG; PRK05667 478434004464 CHC2 zinc finger; Region: zf-CHC2; pfam01807 478434004465 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 478434004466 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 478434004467 active site 478434004468 metal binding site [ion binding]; metal-binding site 478434004469 interdomain interaction site; other site 478434004470 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 478434004471 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 478434004472 PE family; Region: PE; pfam00934 478434004473 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 478434004474 hypothetical protein; Validated; Region: PRK08223 478434004475 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 478434004476 ATP binding site [chemical binding]; other site 478434004477 substrate interface [chemical binding]; other site 478434004478 hypothetical protein; Provisional; Region: PRK14851 478434004479 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 478434004480 serine O-acetyltransferase; Region: cysE; TIGR01172 478434004481 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 478434004482 trimer interface [polypeptide binding]; other site 478434004483 active site 478434004484 substrate binding site [chemical binding]; other site 478434004485 CoA binding site [chemical binding]; other site 478434004486 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 478434004487 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 478434004488 pyridoxal 5'-phosphate binding site [chemical binding]; other site 478434004489 dimer interface [polypeptide binding]; other site 478434004490 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 478434004491 Major Facilitator Superfamily; Region: MFS_1; pfam07690 478434004492 putative substrate translocation pore; other site 478434004493 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 478434004494 putative substrate translocation pore; other site 478434004495 malate dehydrogenase; Provisional; Region: PRK13529 478434004496 Malic enzyme, N-terminal domain; Region: malic; pfam00390 478434004497 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 478434004498 NAD(P) binding site [chemical binding]; other site 478434004499 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 478434004500 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 478434004501 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 478434004502 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 478434004503 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 478434004504 putative substrate translocation pore; other site 478434004505 PE family; Region: PE; pfam00934 478434004506 MarR family; Region: MarR; pfam01047 478434004507 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 478434004508 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 478434004509 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 478434004510 Walker A/P-loop; other site 478434004511 ATP binding site [chemical binding]; other site 478434004512 Q-loop/lid; other site 478434004513 ABC transporter signature motif; other site 478434004514 Walker B; other site 478434004515 D-loop; other site 478434004516 H-loop/switch region; other site 478434004517 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 478434004518 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 478434004519 Walker A/P-loop; other site 478434004520 ATP binding site [chemical binding]; other site 478434004521 Q-loop/lid; other site 478434004522 ABC transporter signature motif; other site 478434004523 Walker B; other site 478434004524 D-loop; other site 478434004525 H-loop/switch region; other site 478434004526 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 478434004527 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 478434004528 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 478434004529 putative DNA binding site [nucleotide binding]; other site 478434004530 putative Zn2+ binding site [ion binding]; other site 478434004531 AsnC family; Region: AsnC_trans_reg; pfam01037 478434004532 Amidinotransferase; Region: Amidinotransf; pfam02274 478434004533 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 478434004534 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 478434004535 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 478434004536 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 478434004537 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 478434004538 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 478434004539 catalytic residue [active] 478434004540 amino acid transporter; Region: 2A0306; TIGR00909 478434004541 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 478434004542 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 478434004543 Ligand Binding Site [chemical binding]; other site 478434004544 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 478434004545 Ligand Binding Site [chemical binding]; other site 478434004546 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 478434004547 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 478434004548 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 478434004549 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 478434004550 dimer interface [polypeptide binding]; other site 478434004551 conserved gate region; other site 478434004552 putative PBP binding loops; other site 478434004553 ABC-ATPase subunit interface; other site 478434004554 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 478434004555 putative PBP binding loops; other site 478434004556 ABC-ATPase subunit interface; other site 478434004557 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 478434004558 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 478434004559 Uncharacterized conserved protein [Function unknown]; Region: COG2128 478434004560 ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member [DNA replication, recombination, and repair]; Region: RecD; COG0507 478434004561 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 478434004562 DNA binding residues [nucleotide binding] 478434004563 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 478434004564 DNA binding site [nucleotide binding] 478434004565 active site 478434004566 Int/Topo IB signature motif; other site 478434004567 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 478434004568 Uncharacterized conserved protein [Function unknown]; Region: COG2442 478434004569 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 478434004570 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 478434004571 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 478434004572 Uncharacterized conserved protein [Function unknown]; Region: COG0398 478434004573 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 478434004574 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 478434004575 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 478434004576 Cutinase; Region: Cutinase; pfam01083 478434004577 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 478434004578 heat shock protein 90; Provisional; Region: PRK05218 478434004579 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 478434004580 ATP binding site [chemical binding]; other site 478434004581 Mg2+ binding site [ion binding]; other site 478434004582 G-X-G motif; other site 478434004583 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 478434004584 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 478434004585 active site 478434004586 catalytic tetrad [active] 478434004587 haloalkane dehalogenase; Provisional; Region: PRK00870 478434004588 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3196 478434004589 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 478434004590 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 478434004591 pyridoxal 5'-phosphate binding site [chemical binding]; other site 478434004592 homodimer interface [polypeptide binding]; other site 478434004593 catalytic residue [active] 478434004594 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 478434004595 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 478434004596 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 478434004597 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 478434004598 active site residue [active] 478434004599 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 478434004600 active site residue [active] 478434004601 CDP-diacylglycerol pyrophosphatase [Lipid metabolism]; Region: Cdh; COG2134 478434004602 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 478434004603 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 478434004604 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 478434004605 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 478434004606 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 478434004607 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 478434004608 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 478434004609 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 478434004610 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 478434004611 Transposase; Region: HTH_Tnp_1; cl17663 478434004612 putative transposase OrfB; Reviewed; Region: PHA02517 478434004613 HTH-like domain; Region: HTH_21; pfam13276 478434004614 Integrase core domain; Region: rve; pfam00665 478434004615 Integrase core domain; Region: rve_3; pfam13683 478434004616 Transcriptional regulator [Transcription]; Region: LysR; COG0583 478434004617 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 478434004618 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 478434004619 dimerization interface [polypeptide binding]; other site 478434004620 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 478434004621 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 478434004622 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 478434004623 FAD binding domain; Region: FAD_binding_4; pfam01565 478434004624 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial protein Rv2277c and similar proteins; Region: GDPD_Rv2277c_like; cd08580 478434004625 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 478434004626 putative active site [active] 478434004627 catalytic site [active] 478434004628 putative metal binding site [ion binding]; other site 478434004629 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 478434004630 Cytochrome P450; Region: p450; cl12078 478434004631 Domain of unknown function (DUF202); Region: DUF202; pfam02656 478434004632 Predicted membrane protein [Function unknown]; Region: COG2149 478434004633 Protein of unknown function (DUF2695); Region: DUF2695; pfam10905 478434004634 Septum formation; Region: Septum_form; pfam13845 478434004635 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 478434004636 Cytochrome P450; Region: p450; cl12078 478434004637 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 478434004638 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 478434004639 Cytochrome P450; Region: p450; cl12078 478434004640 Major Facilitator Superfamily; Region: MFS_1; pfam07690 478434004641 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 478434004642 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 478434004643 nucleotide binding site [chemical binding]; other site 478434004644 short chain dehydrogenase; Provisional; Region: PRK05854 478434004645 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 478434004646 putative NAD(P) binding site [chemical binding]; other site 478434004647 active site 478434004648 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 478434004649 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 478434004650 putative active site [active] 478434004651 catalytic triad [active] 478434004652 putative dimer interface [polypeptide binding]; other site 478434004653 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 478434004654 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 478434004655 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 478434004656 NAD binding site [chemical binding]; other site 478434004657 catalytic Zn binding site [ion binding]; other site 478434004658 substrate binding site [chemical binding]; other site 478434004659 structural Zn binding site [ion binding]; other site 478434004660 Methyltransferase domain; Region: Methyltransf_31; pfam13847 478434004661 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478434004662 S-adenosylmethionine binding site [chemical binding]; other site 478434004663 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 478434004664 Beta-lactamase; Region: Beta-lactamase; pfam00144 478434004665 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 478434004666 diacylglycerol kinase; Reviewed; Region: PRK11914 478434004667 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 478434004668 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 478434004669 FAD binding domain; Region: FAD_binding_4; pfam01565 478434004670 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 478434004671 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478434004672 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 478434004673 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 478434004674 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 478434004675 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 478434004676 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 478434004677 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 478434004678 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 478434004679 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 478434004680 dimer interface [polypeptide binding]; other site 478434004681 active site 478434004682 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 478434004683 dimer interface [polypeptide binding]; other site 478434004684 active site 478434004685 acyl carrier protein; Provisional; Region: acpP; PRK00982 478434004686 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 478434004687 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 478434004688 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 478434004689 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 478434004690 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 478434004691 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 478434004692 dimer interface [polypeptide binding]; other site 478434004693 TPP-binding site [chemical binding]; other site 478434004694 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 478434004695 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 478434004696 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 478434004697 dimer interface [polypeptide binding]; other site 478434004698 catalytic triad [active] 478434004699 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 478434004700 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 478434004701 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 478434004702 Low molecular weight phosphatase family; Region: LMWPc; cd00115 478434004703 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 478434004704 active site 478434004705 phosphoglycolate phosphatase; Provisional; Region: PRK13222 478434004706 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 478434004707 active site 478434004708 motif I; other site 478434004709 motif II; other site 478434004710 PIN domain nuclease, a component of toxin-antitoxin system (PIN domain) [Signal transduction mechanisms]; Region: COG3744 478434004711 hypothetical protein; Provisional; Region: PRK07908 478434004712 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 478434004713 pyridoxal 5'-phosphate binding site [chemical binding]; other site 478434004714 homodimer interface [polypeptide binding]; other site 478434004715 catalytic residue [active] 478434004716 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 478434004717 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 478434004718 Uncharacterized conserved protein [Function unknown]; Region: COG0327 478434004719 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 478434004720 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 478434004721 Putative zinc ribbon domain; Region: DUF164; pfam02591 478434004722 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 478434004723 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 478434004724 RNA/DNA hybrid binding site [nucleotide binding]; other site 478434004725 active site 478434004726 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 478434004727 catalytic core [active] 478434004728 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3826 478434004729 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 478434004730 putative active site; other site 478434004731 putative metal binding residues [ion binding]; other site 478434004732 signature motif; other site 478434004733 putative triphosphate binding site [ion binding]; other site 478434004734 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 478434004735 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 478434004736 oligomerization interface [polypeptide binding]; other site 478434004737 active site 478434004738 metal binding site [ion binding]; metal-binding site 478434004739 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 478434004740 TAP-like protein; Region: Abhydrolase_4; pfam08386 478434004741 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 478434004742 TAP-like protein; Region: Abhydrolase_4; pfam08386 478434004743 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 478434004744 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 478434004745 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 478434004746 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 478434004747 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 478434004748 metal binding triad; other site 478434004749 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 478434004750 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 478434004751 metal binding triad; other site 478434004752 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 478434004753 glutamine synthetase, type I; Region: GlnA; TIGR00653 478434004754 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 478434004755 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 478434004756 RDD family; Region: RDD; pfam06271 478434004757 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 478434004758 lipoyl synthase; Provisional; Region: PRK05481 478434004759 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 478434004760 FeS/SAM binding site; other site 478434004761 lipoate-protein ligase B; Provisional; Region: PRK14345 478434004762 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 478434004763 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 478434004764 putative NAD(P) binding site [chemical binding]; other site 478434004765 putative active site [active] 478434004766 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 478434004767 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 478434004768 E3 interaction surface; other site 478434004769 lipoyl attachment site [posttranslational modification]; other site 478434004770 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 478434004771 E3 interaction surface; other site 478434004772 lipoyl attachment site [posttranslational modification]; other site 478434004773 e3 binding domain; Region: E3_binding; pfam02817 478434004774 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 478434004775 short chain dehydrogenase; Validated; Region: PRK05855 478434004776 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 478434004777 classical (c) SDRs; Region: SDR_c; cd05233 478434004778 NAD(P) binding site [chemical binding]; other site 478434004779 active site 478434004780 multifunctional aminopeptidase A; Provisional; Region: PRK00913 478434004781 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 478434004782 interface (dimer of trimers) [polypeptide binding]; other site 478434004783 Substrate-binding/catalytic site; other site 478434004784 Zn-binding sites [ion binding]; other site 478434004785 cyclase homology domain; Region: CHD; cd07302 478434004786 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 478434004787 nucleotidyl binding site; other site 478434004788 metal binding site [ion binding]; metal-binding site 478434004789 dimer interface [polypeptide binding]; other site 478434004790 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 478434004791 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 478434004792 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 478434004793 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 478434004794 homodimer interface [polypeptide binding]; other site 478434004795 substrate-cofactor binding pocket; other site 478434004796 catalytic residue [active] 478434004797 Cobalamin-5-phosphate synthase; Region: CobS; pfam02654 478434004798 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 478434004799 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 478434004800 putative dimer interface [polypeptide binding]; other site 478434004801 active site pocket [active] 478434004802 putative cataytic base [active] 478434004803 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 478434004804 Glycerate kinase family; Region: Gly_kinase; cl00841 478434004805 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 478434004806 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 478434004807 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 478434004808 substrate binding site [chemical binding]; other site 478434004809 ATP binding site [chemical binding]; other site 478434004810 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 478434004811 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 478434004812 dimer interface [polypeptide binding]; other site 478434004813 active site 478434004814 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 478434004815 Ligand Binding Site [chemical binding]; other site 478434004816 Molecular Tunnel; other site 478434004817 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 478434004818 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 478434004819 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 478434004820 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 478434004821 Protein of unknown function (DUF2561); Region: DUF2561; pfam10812 478434004822 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 478434004823 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 478434004824 heme bH binding site [chemical binding]; other site 478434004825 intrachain domain interface; other site 478434004826 heme bL binding site [chemical binding]; other site 478434004827 interchain domain interface [polypeptide binding]; other site 478434004828 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 478434004829 Qo binding site; other site 478434004830 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 478434004831 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 478434004832 iron-sulfur cluster [ion binding]; other site 478434004833 [2Fe-2S] cluster binding site [ion binding]; other site 478434004834 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 478434004835 Cytochrome c; Region: Cytochrom_C; pfam00034 478434004836 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 478434004837 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 478434004838 Subunit I/III interface [polypeptide binding]; other site 478434004839 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 478434004840 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 478434004841 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 478434004842 hypothetical protein; Validated; Region: PRK07883 478434004843 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 478434004844 active site 478434004845 catalytic site [active] 478434004846 substrate binding site [chemical binding]; other site 478434004847 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 478434004848 GIY-YIG motif/motif A; other site 478434004849 active site 478434004850 catalytic site [active] 478434004851 putative DNA binding site [nucleotide binding]; other site 478434004852 metal binding site [ion binding]; metal-binding site 478434004853 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 478434004854 NlpC/P60 family; Region: NLPC_P60; pfam00877 478434004855 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 478434004856 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 478434004857 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 478434004858 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 478434004859 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 478434004860 acyl-activating enzyme (AAE) consensus motif; other site 478434004861 putative AMP binding site [chemical binding]; other site 478434004862 putative active site [active] 478434004863 putative CoA binding site [chemical binding]; other site 478434004864 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 478434004865 putative hydrophobic ligand binding site [chemical binding]; other site 478434004866 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 478434004867 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 478434004868 DTAP/Switch II; other site 478434004869 Switch I; other site 478434004870 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 478434004871 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 478434004872 putative acyl-acceptor binding pocket; other site 478434004873 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 478434004874 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; COG3200 478434004875 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 478434004876 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 478434004877 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 478434004878 Catalytic domain of Protein Kinases; Region: PKc; cd00180 478434004879 active site 478434004880 ATP binding site [chemical binding]; other site 478434004881 substrate binding site [chemical binding]; other site 478434004882 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 478434004883 substrate binding site [chemical binding]; other site 478434004884 activation loop (A-loop); other site 478434004885 activation loop (A-loop); other site 478434004886 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 478434004887 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 478434004888 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 478434004889 substrate binding pocket [chemical binding]; other site 478434004890 chain length determination region; other site 478434004891 substrate-Mg2+ binding site; other site 478434004892 catalytic residues [active] 478434004893 aspartate-rich region 1; other site 478434004894 active site lid residues [active] 478434004895 aspartate-rich region 2; other site 478434004896 Protein of unknown function (DUF3153); Region: DUF3153; pfam11353 478434004897 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 478434004898 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 478434004899 MraZ protein; Region: MraZ; pfam02381 478434004900 MraZ protein; Region: MraZ; pfam02381 478434004901 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 478434004902 MraW methylase family; Region: Methyltransf_5; pfam01795 478434004903 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 478434004904 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 478434004905 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 478434004906 PE family; Region: PE; pfam00934 478434004907 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 478434004908 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 478434004909 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 478434004910 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 478434004911 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 478434004912 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 478434004913 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 478434004914 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 478434004915 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 478434004916 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 478434004917 Mg++ binding site [ion binding]; other site 478434004918 putative catalytic motif [active] 478434004919 putative substrate binding site [chemical binding]; other site 478434004920 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03369 478434004921 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 478434004922 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 478434004923 cell division protein FtsW; Region: ftsW; TIGR02614 478434004924 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 478434004925 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Region: murG; TIGR01133 478434004926 active site 478434004927 homodimer interface [polypeptide binding]; other site 478434004928 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 478434004929 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 478434004930 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 478434004931 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 478434004932 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 478434004933 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 478434004934 Cell division protein FtsQ; Region: FtsQ; pfam03799 478434004935 cell division protein FtsZ; Validated; Region: PRK09330 478434004936 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 478434004937 nucleotide binding site [chemical binding]; other site 478434004938 SulA interaction site; other site 478434004939 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 478434004940 uncharacterized protein, YfiH family; Region: TIGR00726 478434004941 Predicted enzyme with a TIM-barrel fold [General function prediction only]; Region: COG0325 478434004942 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 478434004943 catalytic residue [active] 478434004944 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 478434004945 Predicted integral membrane protein [Function unknown]; Region: COG0762 478434004946 DivIVA domain; Region: DivI1A_domain; TIGR03544 478434004947 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 478434004948 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 478434004949 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 478434004950 active site 478434004951 putative addiction module component, TIGR02574 family; Region: stabl_TIGR02574 478434004952 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483 478434004953 hypothetical protein; Provisional; Region: PRK07906 478434004954 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 478434004955 putative metal binding site [ion binding]; other site 478434004956 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 478434004957 substrate binding site [chemical binding]; other site 478434004958 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 478434004959 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 478434004960 quinone interaction residues [chemical binding]; other site 478434004961 active site 478434004962 catalytic residues [active] 478434004963 FMN binding site [chemical binding]; other site 478434004964 substrate binding site [chemical binding]; other site 478434004965 undecaprenyl-diphosphatase UppP; Region: undec_PP_bacA; TIGR00753 478434004966 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 478434004967 catalytic core [active] 478434004968 conserved hypothetical protein; Region: TIGR03847 478434004969 conserved hypothetical protein; Region: TIGR03843 478434004970 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 478434004971 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 478434004972 active site 478434004973 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 478434004974 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 478434004975 active site 478434004976 HIGH motif; other site 478434004977 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 478434004978 active site 478434004979 KMSKS motif; other site 478434004980 Anticodon-binding domain of cysteinyl tRNA synthetases and domain found in MshC; Region: Anticodon_Ia_Cys_like; cd07955 478434004981 putative tRNA binding surface [nucleotide binding]; other site 478434004982 short chain dehydrogenase; Provisional; Region: PRK05872 478434004983 classical (c) SDRs; Region: SDR_c; cd05233 478434004984 NAD(P) binding site [chemical binding]; other site 478434004985 active site 478434004986 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 478434004987 PAC2 family; Region: PAC2; pfam09754 478434004988 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 478434004989 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 478434004990 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 478434004991 substrate binding pocket [chemical binding]; other site 478434004992 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 478434004993 B12 binding site [chemical binding]; other site 478434004994 cobalt ligand [ion binding]; other site 478434004995 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 478434004996 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478434004997 PPE family; Region: PPE; pfam00823 478434004998 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 478434004999 homodimer interface [polypeptide binding]; other site 478434005000 putative metal binding site [ion binding]; other site 478434005001 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 478434005002 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 478434005003 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 478434005004 Predicted membrane protein [Function unknown]; Region: COG3918 478434005005 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 478434005006 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 478434005007 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478434005008 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1550 478434005009 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 478434005010 proteasome ATPase; Region: pup_AAA; TIGR03689 478434005011 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 478434005012 Walker A motif; other site 478434005013 ATP binding site [chemical binding]; other site 478434005014 Walker B motif; other site 478434005015 arginine finger; other site 478434005016 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 478434005017 Pup-like protein; Region: Pup; pfam05639 478434005018 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 478434005019 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 478434005020 active site 478434005021 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 478434005022 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 478434005023 active site 478434005024 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478434005025 PPE family; Region: PPE; pfam00823 478434005026 PE family; Region: PE; pfam00934 478434005027 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 478434005028 Transposase; Region: HTH_Tnp_1; cl17663 478434005029 putative transposase OrfB; Reviewed; Region: PHA02517 478434005030 HTH-like domain; Region: HTH_21; pfam13276 478434005031 Integrase core domain; Region: rve; pfam00665 478434005032 Integrase core domain; Region: rve_3; pfam13683 478434005033 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 478434005034 Transposase; Region: HTH_Tnp_1; cl17663 478434005035 putative transposase OrfB; Reviewed; Region: PHA02517 478434005036 HTH-like domain; Region: HTH_21; pfam13276 478434005037 Integrase core domain; Region: rve; pfam00665 478434005038 Integrase core domain; Region: rve_3; pfam13683 478434005039 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 478434005040 putative active site [active] 478434005041 Uncharacterized conserved protein [Function unknown]; Region: COG4279 478434005042 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 478434005043 SNF2 Helicase protein; Region: DUF3670; pfam12419 478434005044 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 478434005045 ATP binding site [chemical binding]; other site 478434005046 putative Mg++ binding site [ion binding]; other site 478434005047 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 478434005048 nucleotide binding region [chemical binding]; other site 478434005049 ATP-binding site [chemical binding]; other site 478434005050 Domain of unknown function (DUF222); Region: DUF222; pfam02720 478434005051 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 478434005052 active site 478434005053 PE family; Region: PE; pfam00934 478434005054 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 478434005055 Predicted transcriptional regulator [Transcription]; Region: COG2378 478434005056 WYL domain; Region: WYL; pfam13280 478434005057 Predicted transcriptional regulator [Transcription]; Region: COG2378 478434005058 WYL domain; Region: WYL; pfam13280 478434005059 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 478434005060 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 478434005061 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 478434005062 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 478434005063 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 478434005064 ATP binding site [chemical binding]; other site 478434005065 putative Mg++ binding site [ion binding]; other site 478434005066 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 478434005067 nucleotide binding region [chemical binding]; other site 478434005068 ATP-binding site [chemical binding]; other site 478434005069 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 478434005070 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 478434005071 5'-3' exonuclease, N-terminal resolvase-like domain; Region: 5_3_exonuc_N; pfam02739 478434005072 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 478434005073 active site 478434005074 metal binding site 1 [ion binding]; metal-binding site 478434005075 putative 5' ssDNA interaction site; other site 478434005076 metal binding site 3; metal-binding site 478434005077 metal binding site 2 [ion binding]; metal-binding site 478434005078 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 478434005079 putative DNA binding site [nucleotide binding]; other site 478434005080 putative metal binding site [ion binding]; other site 478434005081 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 478434005082 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 478434005083 active site 478434005084 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 478434005085 Catalytic domain of Protein Kinases; Region: PKc; cd00180 478434005086 active site 478434005087 ATP binding site [chemical binding]; other site 478434005088 substrate binding site [chemical binding]; other site 478434005089 activation loop (A-loop); other site 478434005090 PknH-like extracellular domain; Region: PknH_C; pfam14032 478434005091 putative transposase OrfB; Reviewed; Region: PHA02517 478434005092 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 478434005093 Protein of unknown function (DUF2563); Region: DUF2563; pfam10817 478434005094 Catalytic domain of uncharacterized Mycobacterium tuberculosis Rv2075c-like proteins; Region: PI-PLCc_Rv2075c_like; cd08590 478434005095 putative active site [active] 478434005096 catalytic site [active] 478434005097 putative metal binding site [ion binding]; other site 478434005098 C-type lectin (CTL)/C-type lectin-like (CTLD) domain; Region: CLECT; cl02432 478434005099 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 478434005100 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 478434005101 NAD(P) binding site [chemical binding]; other site 478434005102 active site 478434005103 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 478434005104 active site 478434005105 putative homodimer interface [polypeptide binding]; other site 478434005106 SAM binding site [chemical binding]; other site 478434005107 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 478434005108 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 478434005109 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 478434005110 active site 478434005111 SAM binding site [chemical binding]; other site 478434005112 homodimer interface [polypeptide binding]; other site 478434005113 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 478434005114 precorrin-6x reductase; Region: precor6x_red; TIGR00715 478434005115 RNA polymerase sigma factor SigC; Reviewed; Region: PRK09649 478434005116 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 478434005117 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 478434005118 DNA binding residues [nucleotide binding] 478434005119 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 478434005120 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 478434005121 Methyltransferase domain; Region: Methyltransf_31; pfam13847 478434005122 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478434005123 S-adenosylmethionine binding site [chemical binding]; other site 478434005124 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 478434005125 active site 478434005126 SAM binding site [chemical binding]; other site 478434005127 homodimer interface [polypeptide binding]; other site 478434005128 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 478434005129 active site 478434005130 SAM binding site [chemical binding]; other site 478434005131 homodimer interface [polypeptide binding]; other site 478434005132 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 478434005133 Precorrin-8X methylmutase; Region: CbiC; pfam02570 478434005134 precorrin-3B synthase; Region: CobG; TIGR02435 478434005135 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 478434005136 PemK-like protein; Region: PemK; pfam02452 478434005137 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 478434005138 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 478434005139 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 478434005140 PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666 478434005141 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 478434005142 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 478434005143 intersubunit interface [polypeptide binding]; other site 478434005144 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 478434005145 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 478434005146 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 478434005147 30S ribosomal protein S18; Provisional; Region: PRK13401 478434005148 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 478434005149 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 478434005150 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 478434005151 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 478434005152 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 478434005153 active site 478434005154 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 478434005155 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 478434005156 putative active site [active] 478434005157 catalytic triad [active] 478434005158 putative dimer interface [polypeptide binding]; other site 478434005159 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 478434005160 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 478434005161 Ligand binding site; other site 478434005162 Putative Catalytic site; other site 478434005163 DXD motif; other site 478434005164 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 478434005165 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 478434005166 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 478434005167 active site 478434005168 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 478434005169 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 478434005170 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 478434005171 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 478434005172 Enoylreductase; Region: PKS_ER; smart00829 478434005173 NAD(P) binding site [chemical binding]; other site 478434005174 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 478434005175 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 478434005176 putative NADP binding site [chemical binding]; other site 478434005177 active site 478434005178 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 478434005179 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 478434005180 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 478434005181 active site 478434005182 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 478434005183 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 478434005184 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 478434005185 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 478434005186 Enoylreductase; Region: PKS_ER; smart00829 478434005187 NAD(P) binding site [chemical binding]; other site 478434005188 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 478434005189 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 478434005190 putative NADP binding site [chemical binding]; other site 478434005191 active site 478434005192 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 478434005193 hypothetical protein; Provisional; Region: PRK05865 478434005194 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 478434005195 NAD(P) binding site [chemical binding]; other site 478434005196 active site 478434005197 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 478434005198 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 478434005199 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 478434005200 substrate binding pocket [chemical binding]; other site 478434005201 catalytic triad [active] 478434005202 Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861 478434005203 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 478434005204 Isochorismatase family; Region: Isochorismatase; pfam00857 478434005205 catalytic triad [active] 478434005206 metal binding site [ion binding]; metal-binding site 478434005207 conserved cis-peptide bond; other site 478434005208 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 478434005209 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 478434005210 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 478434005211 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 478434005212 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 478434005213 dimer interface [polypeptide binding]; other site 478434005214 conserved gate region; other site 478434005215 putative PBP binding loops; other site 478434005216 ABC-ATPase subunit interface; other site 478434005217 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 478434005218 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 478434005219 dimer interface [polypeptide binding]; other site 478434005220 conserved gate region; other site 478434005221 putative PBP binding loops; other site 478434005222 ABC-ATPase subunit interface; other site 478434005223 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 478434005224 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 478434005225 Walker A/P-loop; other site 478434005226 ATP binding site [chemical binding]; other site 478434005227 Q-loop/lid; other site 478434005228 ABC transporter signature motif; other site 478434005229 Walker B; other site 478434005230 D-loop; other site 478434005231 H-loop/switch region; other site 478434005232 TOBE domain; Region: TOBE_2; pfam08402 478434005233 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 478434005234 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 478434005235 nucleophile elbow; other site 478434005236 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 478434005237 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 478434005238 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 478434005239 MDMPI C-terminal domain; Region: MDMPI_C; pfam07398 478434005240 Ligand-binding SRPBCC domain of Micromonospora echinospora CalC and related proteins; Region: SRPBCC_CalC; cd08891 478434005241 putative hydrophobic ligand binding site [chemical binding]; other site 478434005242 CLM binding site; other site 478434005243 L1 loop; other site 478434005244 DNA binding site [nucleotide binding] 478434005245 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 478434005246 putative DNA binding site [nucleotide binding]; other site 478434005247 dimerization interface [polypeptide binding]; other site 478434005248 putative Zn2+ binding site [ion binding]; other site 478434005249 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 478434005250 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 478434005251 dimer interface [polypeptide binding]; other site 478434005252 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 478434005253 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 478434005254 putative dimer interface [polypeptide binding]; other site 478434005255 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 478434005256 active site 478434005257 Erythromycin esterase homolog [General function prediction only]; Region: COG2312 478434005258 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 478434005259 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 478434005260 putative substrate binding site [chemical binding]; other site 478434005261 putative ATP binding site [chemical binding]; other site 478434005262 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 478434005263 Ligand Binding Site [chemical binding]; other site 478434005264 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 478434005265 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 478434005266 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 478434005267 Histidine kinase; Region: HisKA_3; pfam07730 478434005268 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 478434005269 Ligand Binding Site [chemical binding]; other site 478434005270 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 478434005271 Ligand Binding Site [chemical binding]; other site 478434005272 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 478434005273 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 478434005274 Predicted helicase [General function prediction only]; Region: COG4889 478434005275 Restriction endonuclease; Region: Mrr_cat_2; pfam13156 478434005276 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 478434005277 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 478434005278 ATP binding site [chemical binding]; other site 478434005279 putative Mg++ binding site [ion binding]; other site 478434005280 Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271 478434005281 ATP-binding site [chemical binding]; other site 478434005282 Methyltransferase domain; Region: Methyltransf_26; pfam13659 478434005283 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4683 478434005284 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 478434005285 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 478434005286 non-specific DNA binding site [nucleotide binding]; other site 478434005287 salt bridge; other site 478434005288 sequence-specific DNA binding site [nucleotide binding]; other site 478434005289 Predicted helicase [General function prediction only]; Region: COG4889 478434005290 putative transposase OrfB; Reviewed; Region: PHA02517 478434005291 HTH-like domain; Region: HTH_21; pfam13276 478434005292 Integrase core domain; Region: rve; pfam00665 478434005293 Integrase core domain; Region: rve_3; pfam13683 478434005294 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 478434005295 Transposase; Region: HTH_Tnp_1; cl17663 478434005296 Uncharacterized conserved protein [Function unknown]; Region: COG2442 478434005297 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 478434005298 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 478434005299 non-specific DNA binding site [nucleotide binding]; other site 478434005300 salt bridge; other site 478434005301 sequence-specific DNA binding site [nucleotide binding]; other site 478434005302 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 478434005303 Domain of unknown function (DUF222); Region: DUF222; pfam02720 478434005304 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 478434005305 active site 478434005306 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 478434005307 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 478434005308 Transposase; Region: DEDD_Tnp_IS110; pfam01548 478434005309 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 478434005310 Phage envelope protein [General function prediction only]; Region: COG5562 478434005311 Transcriptional regulators [Transcription]; Region: MarR; COG1846 478434005312 MarR family; Region: MarR_2; pfam12802 478434005313 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 478434005314 putative active site [active] 478434005315 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 478434005316 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 478434005317 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 478434005318 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 478434005319 Walker A motif; other site 478434005320 ATP binding site [chemical binding]; other site 478434005321 Walker B motif; other site 478434005322 arginine finger; other site 478434005323 Ferredoxin [Energy production and conversion]; Region: COG1146 478434005324 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 478434005325 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 478434005326 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 478434005327 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 478434005328 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 478434005329 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 478434005330 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 478434005331 Universal stress protein family; Region: Usp; pfam00582 478434005332 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 478434005333 Ligand Binding Site [chemical binding]; other site 478434005334 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 478434005335 Predicted kinase [General function prediction only]; Region: COG0645 478434005336 AAA domain; Region: AAA_17; pfam13207 478434005337 Methyltransferase domain; Region: Methyltransf_23; pfam13489 478434005338 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478434005339 S-adenosylmethionine binding site [chemical binding]; other site 478434005340 3beta17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 3beta-17beta-HSD_like_SDR_c; cd05341 478434005341 homotetramer interface [polypeptide binding]; other site 478434005342 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 478434005343 NAD binding site [chemical binding]; other site 478434005344 homodimer interface [polypeptide binding]; other site 478434005345 active site 478434005346 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 478434005347 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 478434005348 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 478434005349 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 478434005350 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 478434005351 tetramer interface [polypeptide binding]; other site 478434005352 active site 478434005353 Mg2+/Mn2+ binding site [ion binding]; other site 478434005354 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 478434005355 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 478434005356 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 478434005357 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 478434005358 Soluble P-type ATPase [General function prediction only]; Region: COG4087 478434005359 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 478434005360 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 478434005361 Ligand Binding Site [chemical binding]; other site 478434005362 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 478434005363 Ligand Binding Site [chemical binding]; other site 478434005364 Hemerythrin-like domain; Region: Hr-like; cd12108 478434005365 Fe binding site [ion binding]; other site 478434005366 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 478434005367 dimerization interface [polypeptide binding]; other site 478434005368 putative DNA binding site [nucleotide binding]; other site 478434005369 putative Zn2+ binding site [ion binding]; other site 478434005370 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 478434005371 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 478434005372 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 478434005373 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 478434005374 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 478434005375 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 478434005376 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 478434005377 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 478434005378 Uncharacterized conserved protein [Function unknown]; Region: COG5654 478434005379 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478434005380 S-adenosylmethionine binding site [chemical binding]; other site 478434005381 Cellulose binding domain; Region: CBM_2; pfam00553 478434005382 Lysine efflux permease [General function prediction only]; Region: COG1279 478434005383 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 478434005384 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 478434005385 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 478434005386 dimerization interface [polypeptide binding]; other site 478434005387 Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594 478434005388 Cutinase; Region: Cutinase; pfam01083 478434005389 PE family; Region: PE; pfam00934 478434005390 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4423 478434005391 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 478434005392 putative active site [active] 478434005393 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 478434005394 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 478434005395 dimer interface [polypeptide binding]; other site 478434005396 putative radical transfer pathway; other site 478434005397 diiron center [ion binding]; other site 478434005398 tyrosyl radical; other site 478434005399 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 478434005400 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 478434005401 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478434005402 S-adenosylmethionine binding site [chemical binding]; other site 478434005403 Peptidase family M48; Region: Peptidase_M48; pfam01435 478434005404 YacP-like NYN domain; Region: NYN_YacP; cl01491 478434005405 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 478434005406 Protein of unknown function (DUF732); Region: DUF732; pfam05305 478434005407 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 478434005408 mce related protein; Region: MCE; pfam02470 478434005409 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 478434005410 mce related protein; Region: MCE; pfam02470 478434005411 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 478434005412 mce related protein; Region: MCE; pfam02470 478434005413 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 478434005414 mce related protein; Region: MCE; pfam02470 478434005415 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 478434005416 mce related protein; Region: MCE; pfam02470 478434005417 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 478434005418 mce related protein; Region: MCE; pfam02470 478434005419 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 478434005420 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 478434005421 Permease; Region: Permease; pfam02405 478434005422 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 478434005423 Permease; Region: Permease; pfam02405 478434005424 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 478434005425 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478434005426 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 478434005427 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478434005428 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 478434005429 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 478434005430 putative active site [active] 478434005431 Uncharacterized protein family (UPF0156); Region: RHH_2; pfam03693 478434005432 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 478434005433 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 478434005434 non-specific DNA binding site [nucleotide binding]; other site 478434005435 salt bridge; other site 478434005436 sequence-specific DNA binding site [nucleotide binding]; other site 478434005437 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 478434005438 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: VapC; COG1487 478434005439 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 478434005440 Domain of unknown function (DUF222); Region: DUF222; pfam02720 478434005441 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 478434005442 active site 478434005443 SEC-C motif; Region: SEC-C; pfam02810 478434005444 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 478434005445 classical (c) SDR, subgroup 12; Region: SDR_c12; cd08944 478434005446 putative NAD(P) binding site [chemical binding]; other site 478434005447 active site 478434005448 homodimer interface [polypeptide binding]; other site 478434005449 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 478434005450 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 478434005451 GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807 478434005452 dimerization interface [polypeptide binding]; other site 478434005453 active site 478434005454 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 478434005455 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 478434005456 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 478434005457 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 478434005458 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 478434005459 catalytic loop [active] 478434005460 iron binding site [ion binding]; other site 478434005461 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 478434005462 FAD binding pocket [chemical binding]; other site 478434005463 FAD binding motif [chemical binding]; other site 478434005464 phosphate binding motif [ion binding]; other site 478434005465 beta-alpha-beta structure motif; other site 478434005466 NAD binding pocket [chemical binding]; other site 478434005467 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 478434005468 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 478434005469 enoyl-CoA hydratase; Provisional; Region: PRK08290 478434005470 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 478434005471 substrate binding site [chemical binding]; other site 478434005472 oxyanion hole (OAH) forming residues; other site 478434005473 trimer interface [polypeptide binding]; other site 478434005474 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 478434005475 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 478434005476 FAD binding site [chemical binding]; other site 478434005477 substrate binding site [chemical binding]; other site 478434005478 catalytic base [active] 478434005479 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 478434005480 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 478434005481 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 478434005482 active site 478434005483 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 478434005484 dimer interface [polypeptide binding]; other site 478434005485 catalytic triad [active] 478434005486 peroxidatic and resolving cysteines [active] 478434005487 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 478434005488 conserved cys residue [active] 478434005489 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 478434005490 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 478434005491 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 478434005492 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 478434005493 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 478434005494 TIGR03085 family protein; Region: TIGR03085 478434005495 short chain dehydrogenase; Provisional; Region: PRK05867 478434005496 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 478434005497 NAD(P) binding site [chemical binding]; other site 478434005498 active site 478434005499 Uncharacterized conserved protein [Function unknown]; Region: COG3361 478434005500 Domain of unknown function (DUF1942); Region: DUF1942; pfam09167 478434005501 putative fatty-acid--CoA ligase; Provisional; Region: PRK12476 478434005502 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 478434005503 acyl-activating enzyme (AAE) consensus motif; other site 478434005504 active site 478434005505 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 478434005506 Beta-lactamase; Region: Beta-lactamase; pfam00144 478434005507 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 478434005508 Beta-lactamase; Region: Beta-lactamase; pfam00144 478434005509 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 478434005510 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 478434005511 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 478434005512 putative acyl-acceptor binding pocket; other site 478434005513 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 478434005514 putative hydrophobic ligand binding site [chemical binding]; other site 478434005515 protein interface [polypeptide binding]; other site 478434005516 gate; other site 478434005517 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478434005518 PPE family; Region: PPE; pfam00823 478434005519 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478434005520 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478434005521 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478434005522 PPE family; Region: PPE; pfam00823 478434005523 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478434005524 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478434005525 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478434005526 Isocitrate lyase [Energy production and conversion]; Region: AceA; COG2224 478434005527 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 478434005528 tetramer interface [polypeptide binding]; other site 478434005529 active site 478434005530 Mg2+/Mn2+ binding site [ion binding]; other site 478434005531 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 478434005532 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 478434005533 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR3; cd08275 478434005534 putative NAD(P) binding site [chemical binding]; other site 478434005535 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 478434005536 substrate binding site [chemical binding]; other site 478434005537 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 478434005538 substrate binding site [chemical binding]; other site 478434005539 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 478434005540 metal binding site 2 [ion binding]; metal-binding site 478434005541 putative DNA binding helix; other site 478434005542 metal binding site 1 [ion binding]; metal-binding site 478434005543 dimer interface [polypeptide binding]; other site 478434005544 structural Zn2+ binding site [ion binding]; other site 478434005545 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 478434005546 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 478434005547 dimer interface [polypeptide binding]; other site 478434005548 active site 478434005549 heme binding site [chemical binding]; other site 478434005550 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 478434005551 Domain of unknown function (DUF4262); Region: DUF4262; pfam14081 478434005552 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 478434005553 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 478434005554 anti sigma factor interaction site; other site 478434005555 regulatory phosphorylation site [posttranslational modification]; other site 478434005556 Predicted membrane protein [Function unknown]; Region: COG1950 478434005557 putative sialic acid transporter; Region: 2A0112; TIGR00891 478434005558 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 478434005559 putative substrate translocation pore; other site 478434005560 competence damage-inducible protein A; Provisional; Region: PRK00549 478434005561 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 478434005562 putative MPT binding site; other site 478434005563 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 478434005564 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 478434005565 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 478434005566 cyclase homology domain; Region: CHD; cd07302 478434005567 nucleotidyl binding site; other site 478434005568 metal binding site [ion binding]; metal-binding site 478434005569 dimer interface [polypeptide binding]; other site 478434005570 Macro domain, Unknown family 2. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_2; cd03330 478434005571 putative ADP-ribose binding site [chemical binding]; other site 478434005572 Domain of unknown function DUF77; Region: DUF77; pfam01910 478434005573 D-tyrosyl-tRNA(Tyr) deacylase; Provisional; Region: PRK05273 478434005574 putative active site [active] 478434005575 dimerization interface [polypeptide binding]; other site 478434005576 putative tRNAtyr binding site [nucleotide binding]; other site 478434005577 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 478434005578 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 478434005579 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 2; Region: FDH_like_2; cd08284 478434005580 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 478434005581 catalytic Zn binding site [ion binding]; other site 478434005582 NAD(P) binding site [chemical binding]; other site 478434005583 structural Zn binding site [ion binding]; other site 478434005584 Nitronate monooxygenase; Region: NMO; pfam03060 478434005585 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 478434005586 FMN binding site [chemical binding]; other site 478434005587 substrate binding site [chemical binding]; other site 478434005588 putative catalytic residue [active] 478434005589 Uncharacterized conserved protein [Function unknown]; Region: COG2353 478434005590 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 478434005591 Leucine carboxyl methyltransferase; Region: LCM; cl01306 478434005592 Leucine carboxyl methyltransferase; Region: LCM; cl01306 478434005593 Putative esterase; Region: Esterase; pfam00756 478434005594 chorismate mutase; Provisional; Region: PRK09269 478434005595 chorismate mutase, putative; Region: CM_mono2; TIGR01806 478434005596 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 478434005597 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 478434005598 hydrophobic ligand binding site; other site 478434005599 short chain dehydrogenase; Provisional; Region: PRK08267 478434005600 classical (c) SDR, subgroup 9; Region: SDR_c9; cd08931 478434005601 putative NAD(P) binding site [chemical binding]; other site 478434005602 active site 478434005603 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 478434005604 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 478434005605 Cytochrome P450; Region: p450; cl12078 478434005606 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 478434005607 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 478434005608 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 478434005609 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 478434005610 Major Facilitator Superfamily; Region: MFS_1; pfam07690 478434005611 putative substrate translocation pore; other site 478434005612 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 478434005613 putative substrate translocation pore; other site 478434005614 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cl00333 478434005615 23S rRNA interface [nucleotide binding]; other site 478434005616 L3 interface [polypeptide binding]; other site 478434005617 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 478434005618 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 478434005619 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 478434005620 heme binding site [chemical binding]; other site 478434005621 ferroxidase pore; other site 478434005622 ferroxidase diiron center [ion binding]; other site 478434005623 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 478434005624 Uncharacterized conserved protein [Function unknown]; Region: COG5579 478434005625 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 478434005626 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 478434005627 active site 478434005628 substrate binding site [chemical binding]; other site 478434005629 FMN binding site [chemical binding]; other site 478434005630 putative catalytic residues [active] 478434005631 Domain of unknown function (DUF385); Region: DUF385; pfam04075 478434005632 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 478434005633 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 478434005634 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 478434005635 hypothetical protein; Provisional; Region: PRK12320 478434005636 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 478434005637 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 478434005638 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 478434005639 active site 478434005640 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 478434005641 CoA-transferase family III; Region: CoA_transf_3; pfam02515 478434005642 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 478434005643 CoA-transferase family III; Region: CoA_transf_3; pfam02515 478434005644 short chain dehydrogenase; Provisional; Region: PRK07825 478434005645 classical (c) SDRs; Region: SDR_c; cd05233 478434005646 NAD(P) binding site [chemical binding]; other site 478434005647 active site 478434005648 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 478434005649 MOSC domain; Region: MOSC; pfam03473 478434005650 CAAX protease self-immunity; Region: Abi; pfam02517 478434005651 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 478434005652 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822 478434005653 putative NAD(P) binding site [chemical binding]; other site 478434005654 putative substrate binding site [chemical binding]; other site 478434005655 catalytic Zn binding site [ion binding]; other site 478434005656 structural Zn binding site [ion binding]; other site 478434005657 Predicted membrane protein [Function unknown]; Region: COG2261 478434005658 Fibronectin-attachment protein (FAP); Region: FAP; pfam07174 478434005659 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 478434005660 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 478434005661 Walker A/P-loop; other site 478434005662 ATP binding site [chemical binding]; other site 478434005663 Q-loop/lid; other site 478434005664 ABC transporter signature motif; other site 478434005665 Walker B; other site 478434005666 D-loop; other site 478434005667 H-loop/switch region; other site 478434005668 TOBE domain; Region: TOBE; pfam03459 478434005669 sulfate transport protein; Provisional; Region: cysT; CHL00187 478434005670 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 478434005671 dimer interface [polypeptide binding]; other site 478434005672 conserved gate region; other site 478434005673 putative PBP binding loops; other site 478434005674 ABC-ATPase subunit interface; other site 478434005675 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 478434005676 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 478434005677 classical (c) SDRs; Region: SDR_c; cd05233 478434005678 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 478434005679 NAD(P) binding site [chemical binding]; other site 478434005680 active site 478434005681 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 478434005682 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 478434005683 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 478434005684 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 478434005685 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 478434005686 UreD urease accessory protein; Region: UreD; cl00530 478434005687 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 478434005688 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 478434005689 UreF; Region: UreF; pfam01730 478434005690 urease subunit alpha; Reviewed; Region: ureC; PRK13206 478434005691 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 478434005692 subunit interactions [polypeptide binding]; other site 478434005693 active site 478434005694 flap region; other site 478434005695 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 478434005696 gamma-beta subunit interface [polypeptide binding]; other site 478434005697 alpha-beta subunit interface [polypeptide binding]; other site 478434005698 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 478434005699 alpha-gamma subunit interface [polypeptide binding]; other site 478434005700 beta-gamma subunit interface [polypeptide binding]; other site 478434005701 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 478434005702 CoenzymeA binding site [chemical binding]; other site 478434005703 subunit interaction site [polypeptide binding]; other site 478434005704 PHB binding site; other site 478434005705 Predicted transcriptional regulator [Transcription]; Region: COG3682 478434005706 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 478434005707 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 478434005708 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 478434005709 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 478434005710 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 478434005711 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 478434005712 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 478434005713 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 478434005714 active site 478434005715 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 478434005716 Domain of unknown function DUF21; Region: DUF21; pfam01595 478434005717 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 478434005718 Transporter associated domain; Region: CorC_HlyC; smart01091 478434005719 Domain of unknown function DUF21; Region: DUF21; pfam01595 478434005720 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 478434005721 FOG: CBS domain [General function prediction only]; Region: COG0517 478434005722 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 478434005723 putative active site [active] 478434005724 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 478434005725 active site 478434005726 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 478434005727 metal ion-dependent adhesion site (MIDAS); other site 478434005728 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 478434005729 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 478434005730 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 478434005731 haloalkane dehalogenase; Provisional; Region: PRK03204 478434005732 glycine dehydrogenase; Provisional; Region: PRK05367 478434005733 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 478434005734 pyridoxal 5'-phosphate binding site [chemical binding]; other site 478434005735 tetramer interface [polypeptide binding]; other site 478434005736 catalytic residue [active] 478434005737 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 478434005738 tetramer interface [polypeptide binding]; other site 478434005739 pyridoxal 5'-phosphate binding site [chemical binding]; other site 478434005740 catalytic residue [active] 478434005741 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 478434005742 DNA binding residues [nucleotide binding] 478434005743 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 478434005744 putative dimer interface [polypeptide binding]; other site 478434005745 Bifunctional nuclease; Region: DNase-RNase; pfam02577 478434005746 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 478434005747 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 478434005748 DNA binding residues [nucleotide binding] 478434005749 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 478434005750 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 478434005751 phosphopeptide binding site; other site 478434005752 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 478434005753 lipoyl attachment site [posttranslational modification]; other site 478434005754 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 478434005755 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 478434005756 Uncharacterized conserved protein (small basic protein) [Function unknown]; Region: Sbp; COG3856 478434005757 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 478434005758 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 478434005759 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 478434005760 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 478434005761 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 478434005762 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 478434005763 nucleotide binding region [chemical binding]; other site 478434005764 ATP-binding site [chemical binding]; other site 478434005765 hypothetical protein; Provisional; Region: PRK05858 478434005766 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 478434005767 PYR/PP interface [polypeptide binding]; other site 478434005768 dimer interface [polypeptide binding]; other site 478434005769 TPP binding site [chemical binding]; other site 478434005770 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 478434005771 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 478434005772 TPP-binding site; other site 478434005773 dimer interface [polypeptide binding]; other site 478434005774 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 478434005775 ABC transporter transmembrane region 2; Region: ABC_membrane_2; pfam06472 478434005776 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 478434005777 PE family; Region: PE; pfam00934 478434005778 hypothetical protein; Validated; Region: PRK07121 478434005779 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 478434005780 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 478434005781 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 478434005782 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 478434005783 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 478434005784 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 478434005785 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 478434005786 MgtC family; Region: MgtC; pfam02308 478434005787 Protein of unknown function (DUF732); Region: DUF732; pfam05305 478434005788 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478434005789 PPE family; Region: PPE; pfam00823 478434005790 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 478434005791 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478434005792 PPE family; Region: PPE; pfam00823 478434005793 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478434005794 PPE family; Region: PPE; pfam00823 478434005795 PE family; Region: PE; pfam00934 478434005796 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 478434005797 Transposase; Region: HTH_Tnp_1; cl17663 478434005798 putative transposase OrfB; Reviewed; Region: PHA02517 478434005799 HTH-like domain; Region: HTH_21; pfam13276 478434005800 Integrase core domain; Region: rve; pfam00665 478434005801 Integrase core domain; Region: rve_3; pfam13683 478434005802 Protein of unknown function (DUF732); Region: DUF732; pfam05305 478434005803 PE family; Region: PE; pfam00934 478434005804 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478434005805 PPE family; Region: PPE; pfam00823 478434005806 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478434005807 PPE family; Region: PPE; pfam00823 478434005808 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478434005809 PPE family; Region: PPE; pfam00823 478434005810 PE-PPE domain; Region: PE-PPE; pfam08237 478434005811 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 478434005812 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 478434005813 Walker A motif; other site 478434005814 ATP binding site [chemical binding]; other site 478434005815 Walker B motif; other site 478434005816 arginine finger; other site 478434005817 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 478434005818 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 478434005819 catalytic residues [active] 478434005820 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 478434005821 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 478434005822 active site 478434005823 catalytic residues [active] 478434005824 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 478434005825 EspG family; Region: ESX-1_EspG; pfam14011 478434005826 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 478434005827 Proteins of 100 residues with WXG; Region: WXG100; cl02005 478434005828 PE family; Region: PE; pfam00934 478434005829 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478434005830 PPE family; Region: PPE; pfam00823 478434005831 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 478434005832 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478434005833 PPE family; Region: PPE; pfam00823 478434005834 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 478434005835 PE family; Region: PE; pfam00934 478434005836 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478434005837 PPE family; Region: PPE; pfam00823 478434005838 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 478434005839 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 478434005840 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 478434005841 Cytochrome P450; Region: p450; cl12078 478434005842 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 478434005843 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 478434005844 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 478434005845 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 478434005846 Protein of unknown function (DUF690); Region: DUF690; pfam05108 478434005847 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 478434005848 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362 478434005849 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 478434005850 Cytochrome P450; Region: p450; cl12078 478434005851 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 478434005852 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478434005853 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 478434005854 FAD binding domain; Region: FAD_binding_4; pfam01565 478434005855 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 478434005856 Transcriptional regulator [Transcription]; Region: IclR; COG1414 478434005857 Bacterial transcriptional regulator; Region: IclR; pfam01614 478434005858 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 478434005859 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 478434005860 FAD binding domain; Region: FAD_binding_4; pfam01565 478434005861 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 478434005862 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 478434005863 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 478434005864 metal binding site [ion binding]; metal-binding site 478434005865 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 478434005866 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813 478434005867 dimer interface [polypeptide binding]; other site 478434005868 active site 478434005869 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 478434005870 substrate binding site [chemical binding]; other site 478434005871 catalytic residue [active] 478434005872 PE family; Region: PE; pfam00934 478434005873 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 478434005874 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 478434005875 putative homotetramer interface [polypeptide binding]; other site 478434005876 putative homodimer interface [polypeptide binding]; other site 478434005877 putative allosteric switch controlling residues; other site 478434005878 putative metal binding site [ion binding]; other site 478434005879 putative homodimer-homodimer interface [polypeptide binding]; other site 478434005880 Integrase core domain; Region: rve; pfam00665 478434005881 Domain of unknown function (DUF222); Region: DUF222; pfam02720 478434005882 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 478434005883 active site 478434005884 Uncharacterized conserved protein [Function unknown]; Region: COG0393 478434005885 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 478434005886 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 478434005887 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 478434005888 Cutinase; Region: Cutinase; pfam01083 478434005889 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 478434005890 Transposase; Region: HTH_Tnp_1; cl17663 478434005891 putative transposase OrfB; Reviewed; Region: PHA02517 478434005892 HTH-like domain; Region: HTH_21; pfam13276 478434005893 Integrase core domain; Region: rve; pfam00665 478434005894 Integrase core domain; Region: rve_3; pfam13683 478434005895 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 478434005896 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478434005897 PPE family; Region: PPE; pfam00823 478434005898 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478434005899 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478434005900 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 478434005901 hypothetical protein; Provisional; Region: PRK06185 478434005902 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 478434005903 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 478434005904 acyl-CoA synthetase; Provisional; Region: PRK13388 478434005905 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 478434005906 acyl-activating enzyme (AAE) consensus motif; other site 478434005907 AMP binding site [chemical binding]; other site 478434005908 active site 478434005909 CoA binding site [chemical binding]; other site 478434005910 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 478434005911 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 478434005912 phosphopeptide binding site; other site 478434005913 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 478434005914 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 478434005915 phosphopeptide binding site; other site 478434005916 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 478434005917 The Eye Pigment Precursor Transporter (EPP) Family protein; Region: 3a01204; TIGR00955 478434005918 Walker A/P-loop; other site 478434005919 ATP binding site [chemical binding]; other site 478434005920 Q-loop/lid; other site 478434005921 ABC transporter signature motif; other site 478434005922 Walker B; other site 478434005923 D-loop; other site 478434005924 H-loop/switch region; other site 478434005925 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 478434005926 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 478434005927 Catalytic domain of Protein Kinases; Region: PKc; cd00180 478434005928 active site 478434005929 ATP binding site [chemical binding]; other site 478434005930 substrate binding site [chemical binding]; other site 478434005931 activation loop (A-loop); other site 478434005932 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 478434005933 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 478434005934 active site 478434005935 metal binding site [ion binding]; metal-binding site 478434005936 nudix motif; other site 478434005937 Protein tyrosine kinase; Region: Pkinase_Tyr; pfam07714 478434005938 Catalytic domain of Protein Kinases; Region: PKc; cd00180 478434005939 active site 478434005940 ATP binding site [chemical binding]; other site 478434005941 substrate binding site [chemical binding]; other site 478434005942 activation loop (A-loop); other site 478434005943 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 478434005944 Thioredoxin; Region: Thioredoxin_4; cl17273 478434005945 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3742 478434005946 putative active site [active] 478434005947 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4423 478434005948 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 478434005949 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 478434005950 Sulfate transporter family; Region: Sulfate_transp; pfam00916 478434005951 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 478434005952 Domain of unknown function (DUF1876); Region: DUF1876; pfam08962 478434005953 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 478434005954 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 478434005955 putative substrate translocation pore; other site 478434005956 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 478434005957 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 478434005958 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 478434005959 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 478434005960 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_1; cd09319 478434005961 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 478434005962 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_1; cd09319 478434005963 gating phenylalanine in ion channel; other site 478434005964 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes [Energy production and conversion]; Region: AceF; COG0508 478434005965 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 478434005966 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 478434005967 putative catalytic residue [active] 478434005968 succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407 478434005969 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101 478434005970 NAD(P) binding site [chemical binding]; other site 478434005971 catalytic residues [active] 478434005972 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 478434005973 Beta-lactamase; Region: Beta-lactamase; pfam00144 478434005974 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 478434005975 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 478434005976 TIGR03086 family protein; Region: TIGR03086 478434005977 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 478434005978 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 478434005979 FAD binding domain; Region: FAD_binding_4; pfam01565 478434005980 Berberine and berberine like; Region: BBE; pfam08031 478434005981 Predicted transcriptional regulators [Transcription]; Region: COG1733 478434005982 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 478434005983 dimerization interface [polypeptide binding]; other site 478434005984 putative DNA binding site [nucleotide binding]; other site 478434005985 putative Zn2+ binding site [ion binding]; other site 478434005986 Predicted transcriptional regulators [Transcription]; Region: COG1733 478434005987 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 478434005988 Beta-lactamase; Region: Beta-lactamase; pfam00144 478434005989 biotin carboxylase-like protein; Validated; Region: PRK06524 478434005990 ATP-grasp domain; Region: ATP-grasp_4; cl17255 478434005991 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 478434005992 putative active site [active] 478434005993 homotetrameric interface [polypeptide binding]; other site 478434005994 metal binding site [ion binding]; metal-binding site 478434005995 Transcriptional regulator [Transcription]; Region: IclR; COG1414 478434005996 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 478434005997 putative switch regulator; other site 478434005998 non-specific DNA interactions [nucleotide binding]; other site 478434005999 DNA binding site [nucleotide binding] 478434006000 sequence specific DNA binding site [nucleotide binding]; other site 478434006001 putative cAMP binding site [chemical binding]; other site 478434006002 Bacterial transcriptional regulator; Region: IclR; pfam01614 478434006003 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 478434006004 Cupin domain; Region: Cupin_2; cl17218 478434006005 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 478434006006 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 478434006007 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 478434006008 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 478434006009 short chain dehydrogenase; Provisional; Region: PRK07060 478434006010 classical (c) SDRs; Region: SDR_c; cd05233 478434006011 NAD(P) binding site [chemical binding]; other site 478434006012 active site 478434006013 GTP-binding protein Der; Reviewed; Region: PRK03003 478434006014 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 478434006015 GTP/Mg2+ binding site [chemical binding]; other site 478434006016 Switch I region; other site 478434006017 G2 box; other site 478434006018 Switch II region; other site 478434006019 G3 box; other site 478434006020 G4 box; other site 478434006021 G5 box; other site 478434006022 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 478434006023 G1 box; other site 478434006024 GTP/Mg2+ binding site [chemical binding]; other site 478434006025 Switch I region; other site 478434006026 G2 box; other site 478434006027 G3 box; other site 478434006028 Switch II region; other site 478434006029 G4 box; other site 478434006030 G5 box; other site 478434006031 cytidylate kinase; Provisional; Region: cmk; PRK00023 478434006032 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 478434006033 CMP-binding site; other site 478434006034 The sites determining sugar specificity; other site 478434006035 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 478434006036 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 478434006037 RNA binding surface [nucleotide binding]; other site 478434006038 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 478434006039 active site 478434006040 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 478434006041 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 478434006042 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 478434006043 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 478434006044 P-loop; other site 478434006045 Magnesium ion binding site [ion binding]; other site 478434006046 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 478434006047 Magnesium ion binding site [ion binding]; other site 478434006048 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 478434006049 Sulfate transporter family; Region: Sulfate_transp; pfam00916 478434006050 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 478434006051 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478434006052 PPE family; Region: PPE; pfam00823 478434006053 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 478434006054 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478434006055 PPE family; Region: PPE; pfam00823 478434006056 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 478434006057 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 478434006058 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 478434006059 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478434006060 S-adenosylmethionine binding site [chemical binding]; other site 478434006061 Domain of unknown function (DUF222); Region: DUF222; pfam02720 478434006062 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 478434006063 active site 478434006064 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 478434006065 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 478434006066 active site 478434006067 DNA binding site [nucleotide binding] 478434006068 Int/Topo IB signature motif; other site 478434006069 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 478434006070 dimer interface [polypeptide binding]; other site 478434006071 ADP-ribose binding site [chemical binding]; other site 478434006072 active site 478434006073 nudix motif; other site 478434006074 metal binding site [ion binding]; metal-binding site 478434006075 CTP synthetase; Validated; Region: pyrG; PRK05380 478434006076 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 478434006077 Catalytic site [active] 478434006078 active site 478434006079 UTP binding site [chemical binding]; other site 478434006080 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 478434006081 active site 478434006082 putative oxyanion hole; other site 478434006083 catalytic triad [active] 478434006084 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 478434006085 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 478434006086 Thiamine pyrophosphokinase; Region: TPK; cl08415 478434006087 Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555 478434006088 DNA repair protein RecN; Region: recN; TIGR00634 478434006089 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 478434006090 Walker A/P-loop; other site 478434006091 ATP binding site [chemical binding]; other site 478434006092 Q-loop/lid; other site 478434006093 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 478434006094 ABC transporter signature motif; other site 478434006095 Walker B; other site 478434006096 D-loop; other site 478434006097 H-loop/switch region; other site 478434006098 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 478434006099 ATP-NAD kinase; Region: NAD_kinase; pfam01513 478434006100 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 478434006101 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 478434006102 RNA binding surface [nucleotide binding]; other site 478434006103 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478434006104 S-adenosylmethionine binding site [chemical binding]; other site 478434006105 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 478434006106 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 478434006107 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 478434006108 Tetratrico peptide repeat; Region: TPR_5; pfam12688 478434006109 Protein of unknown function (DUF732); Region: DUF732; pfam05305 478434006110 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 478434006111 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 478434006112 active site 478434006113 HIGH motif; other site 478434006114 dimer interface [polypeptide binding]; other site 478434006115 KMSKS motif; other site 478434006116 S4 RNA-binding domain; Region: S4; smart00363 478434006117 RNA binding surface [nucleotide binding]; other site 478434006118 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 478434006119 active site 478434006120 DNA binding site [nucleotide binding] 478434006121 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 478434006122 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 478434006123 Walker A/P-loop; other site 478434006124 ATP binding site [chemical binding]; other site 478434006125 Q-loop/lid; other site 478434006126 ABC transporter signature motif; other site 478434006127 Walker B; other site 478434006128 D-loop; other site 478434006129 H-loop/switch region; other site 478434006130 ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025 478434006131 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 478434006132 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 478434006133 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478434006134 Uncharacterized conserved protein [Function unknown]; Region: COG2835 478434006135 acyl-CoA synthetase; Validated; Region: PRK07868 478434006136 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 478434006137 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 478434006138 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 478434006139 acyl-activating enzyme (AAE) consensus motif; other site 478434006140 AMP binding site [chemical binding]; other site 478434006141 active site 478434006142 CoA binding site [chemical binding]; other site 478434006143 DivIVA protein; Region: DivIVA; pfam05103 478434006144 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 478434006145 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 478434006146 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 478434006147 FeS/SAM binding site; other site 478434006148 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 478434006149 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 478434006150 substrate binding pocket [chemical binding]; other site 478434006151 membrane-bound complex binding site; other site 478434006152 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 478434006153 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 478434006154 active site 478434006155 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 478434006156 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 478434006157 catalytic residues [active] 478434006158 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 478434006159 putative catalytic residues [active] 478434006160 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 478434006161 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 478434006162 ligand binding site [chemical binding]; other site 478434006163 flexible hinge region; other site 478434006164 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 478434006165 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 478434006166 dimerization interface [polypeptide binding]; other site 478434006167 putative DNA binding site [nucleotide binding]; other site 478434006168 putative Zn2+ binding site [ion binding]; other site 478434006169 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 478434006170 active site residue [active] 478434006171 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 478434006172 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 478434006173 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 478434006174 putative substrate translocation pore; other site 478434006175 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 478434006176 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 478434006177 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 478434006178 ABC transporter; Region: ABC_tran_2; pfam12848 478434006179 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 478434006180 Cytochrome P450; Region: p450; cl12078 478434006181 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 478434006182 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 478434006183 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 478434006184 malonyl-CoA binding site [chemical binding]; other site 478434006185 dimer interface [polypeptide binding]; other site 478434006186 active site 478434006187 product binding site; other site 478434006188 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 478434006189 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 478434006190 active site 478434006191 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 478434006192 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 478434006193 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 478434006194 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 478434006195 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 478434006196 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 478434006197 putative NADP binding site [chemical binding]; other site 478434006198 active site 478434006199 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 478434006200 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 478434006201 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 478434006202 active site 478434006203 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 478434006204 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 478434006205 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 478434006206 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 478434006207 Enoylreductase; Region: PKS_ER; smart00829 478434006208 NAD(P) binding site [chemical binding]; other site 478434006209 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 478434006210 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 478434006211 active site 478434006212 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 478434006213 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 478434006214 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 478434006215 Enoylreductase; Region: PKS_ER; smart00829 478434006216 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 478434006217 NAD(P) binding site [chemical binding]; other site 478434006218 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 478434006219 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 478434006220 putative NADP binding site [chemical binding]; other site 478434006221 active site 478434006222 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 478434006223 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 478434006224 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 478434006225 malonyl-CoA binding site [chemical binding]; other site 478434006226 dimer interface [polypeptide binding]; other site 478434006227 active site 478434006228 product binding site; other site 478434006229 argininosuccinate lyase; Provisional; Region: PRK00855 478434006230 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 478434006231 active sites [active] 478434006232 tetramer interface [polypeptide binding]; other site 478434006233 argininosuccinate synthase; Provisional; Region: PRK13820 478434006234 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 478434006235 ANP binding site [chemical binding]; other site 478434006236 Substrate Binding Site II [chemical binding]; other site 478434006237 Substrate Binding Site I [chemical binding]; other site 478434006238 arginine repressor; Provisional; Region: PRK03341 478434006239 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 478434006240 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 478434006241 ornithine carbamoyltransferase; Provisional; Region: PRK00779 478434006242 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 478434006243 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 478434006244 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 478434006245 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 478434006246 inhibitor-cofactor binding pocket; inhibition site 478434006247 pyridoxal 5'-phosphate binding site [chemical binding]; other site 478434006248 catalytic residue [active] 478434006249 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 478434006250 feedback inhibition sensing region; other site 478434006251 homohexameric interface [polypeptide binding]; other site 478434006252 nucleotide binding site [chemical binding]; other site 478434006253 N-acetyl-L-glutamate binding site [chemical binding]; other site 478434006254 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 478434006255 heterotetramer interface [polypeptide binding]; other site 478434006256 active site pocket [active] 478434006257 cleavage site 478434006258 N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850 478434006259 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 478434006260 PE family; Region: PE; pfam00934 478434006261 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 478434006262 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 478434006263 putative tRNA-binding site [nucleotide binding]; other site 478434006264 B3/4 domain; Region: B3_4; pfam03483 478434006265 tRNA synthetase B5 domain; Region: B5; smart00874 478434006266 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 478434006267 dimer interface [polypeptide binding]; other site 478434006268 motif 1; other site 478434006269 motif 3; other site 478434006270 motif 2; other site 478434006271 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 478434006272 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 478434006273 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 478434006274 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 478434006275 dimer interface [polypeptide binding]; other site 478434006276 motif 1; other site 478434006277 active site 478434006278 motif 2; other site 478434006279 motif 3; other site 478434006280 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 478434006281 cyclase homology domain; Region: CHD; cd07302 478434006282 nucleotidyl binding site; other site 478434006283 metal binding site [ion binding]; metal-binding site 478434006284 dimer interface [polypeptide binding]; other site 478434006285 PE family; Region: PE; pfam00934 478434006286 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 478434006287 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 478434006288 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 478434006289 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 478434006290 23S rRNA binding site [nucleotide binding]; other site 478434006291 L21 binding site [polypeptide binding]; other site 478434006292 L13 binding site [polypeptide binding]; other site 478434006293 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 478434006294 translation initiation factor IF-3; Region: infC; TIGR00168 478434006295 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 478434006296 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 478434006297 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 478434006298 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 478434006299 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 478434006300 dimer interface [polypeptide binding]; other site 478434006301 putative anticodon binding site; other site 478434006302 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 478434006303 motif 1; other site 478434006304 dimer interface [polypeptide binding]; other site 478434006305 active site 478434006306 motif 2; other site 478434006307 motif 3; other site 478434006308 Predicted esterase [General function prediction only]; Region: COG0627 478434006309 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 478434006310 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 478434006311 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 478434006312 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 478434006313 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 478434006314 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 478434006315 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 478434006316 Ligand Binding Site [chemical binding]; other site 478434006317 Predicted membrane protein [Function unknown]; Region: COG5305 478434006318 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 478434006319 Major Facilitator Superfamily; Region: MFS_1; pfam07690 478434006320 putative substrate translocation pore; other site 478434006321 excinuclease ABC subunit B; Provisional; Region: PRK05298 478434006322 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 478434006323 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 478434006324 nucleotide binding region [chemical binding]; other site 478434006325 ATP-binding site [chemical binding]; other site 478434006326 Ultra-violet resistance protein B; Region: UvrB; pfam12344 478434006327 UvrB/uvrC motif; Region: UVR; pfam02151 478434006328 Predicted RNA-binding protein, associated with RNAses E/G family [General function prediction only]; Region: COG2306 478434006329 dephospho-CoA kinase/protein folding accessory domain-containing protein; Provisional; Region: coaE; PRK03333 478434006330 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 478434006331 CoA-binding site [chemical binding]; other site 478434006332 ATP-binding [chemical binding]; other site 478434006333 Uncharacterized conserved protein [Function unknown]; Region: GrpB; COG2320 478434006334 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 478434006335 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 478434006336 RNA binding site [nucleotide binding]; other site 478434006337 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 478434006338 RNA binding site [nucleotide binding]; other site 478434006339 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 478434006340 RNA binding site [nucleotide binding]; other site 478434006341 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 478434006342 RNA binding site [nucleotide binding]; other site 478434006343 DNA polymerase I; Provisional; Region: PRK05755 478434006344 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 478434006345 active site 478434006346 metal binding site 1 [ion binding]; metal-binding site 478434006347 putative 5' ssDNA interaction site; other site 478434006348 metal binding site 3; metal-binding site 478434006349 metal binding site 2 [ion binding]; metal-binding site 478434006350 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 478434006351 putative DNA binding site [nucleotide binding]; other site 478434006352 putative metal binding site [ion binding]; other site 478434006353 3'-5' exonuclease; Region: 35EXOc; smart00474 478434006354 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 478434006355 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 478434006356 active site 478434006357 DNA binding site [nucleotide binding] 478434006358 catalytic site [active] 478434006359 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 478434006360 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 478434006361 DUF35 OB-fold domain; Region: DUF35; pfam01796 478434006362 lipid-transfer protein; Provisional; Region: PRK06059 478434006363 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 478434006364 active site 478434006365 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 478434006366 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 478434006367 active site 478434006368 phosphorylation site [posttranslational modification] 478434006369 intermolecular recognition site; other site 478434006370 dimerization interface [polypeptide binding]; other site 478434006371 ANTAR domain; Region: ANTAR; pfam03861 478434006372 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 478434006373 cyclase homology domain; Region: CHD; cd07302 478434006374 nucleotidyl binding site; other site 478434006375 metal binding site [ion binding]; metal-binding site 478434006376 dimer interface [polypeptide binding]; other site 478434006377 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 478434006378 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 478434006379 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 478434006380 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 478434006381 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 478434006382 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 478434006383 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 478434006384 Walker A/P-loop; other site 478434006385 ATP binding site [chemical binding]; other site 478434006386 Q-loop/lid; other site 478434006387 ABC transporter signature motif; other site 478434006388 Walker B; other site 478434006389 D-loop; other site 478434006390 H-loop/switch region; other site 478434006391 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 478434006392 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 478434006393 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 478434006394 Walker A/P-loop; other site 478434006395 Walker A/P-loop; other site 478434006396 ATP binding site [chemical binding]; other site 478434006397 ATP binding site [chemical binding]; other site 478434006398 Q-loop/lid; other site 478434006399 Uncharacterized conserved protein [Function unknown]; Region: COG2898 478434006400 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 478434006401 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 478434006402 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 478434006403 active site 478434006404 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 478434006405 catalytic triad [active] 478434006406 dimer interface [polypeptide binding]; other site 478434006407 pyruvate kinase; Provisional; Region: PRK06247 478434006408 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 478434006409 domain interfaces; other site 478434006410 active site 478434006411 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 478434006412 TM2 domain; Region: TM2; pfam05154 478434006413 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK13108 478434006414 Prolipoprotein diacylglyceryltransferase [Cell envelope biogenesis, outer membrane]; Region: Lgt; COG0682 478434006415 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 478434006416 substrate binding site [chemical binding]; other site 478434006417 active site 478434006418 catalytic residues [active] 478434006419 heterodimer interface [polypeptide binding]; other site 478434006420 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 478434006421 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 478434006422 pyridoxal 5'-phosphate binding site [chemical binding]; other site 478434006423 catalytic residue [active] 478434006424 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 478434006425 active site 478434006426 ribulose/triose binding site [chemical binding]; other site 478434006427 phosphate binding site [ion binding]; other site 478434006428 substrate (anthranilate) binding pocket [chemical binding]; other site 478434006429 product (indole) binding pocket [chemical binding]; other site 478434006430 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534 478434006431 anthranilate synthase component I; Provisional; Region: PRK13571 478434006432 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 478434006433 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 478434006434 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 478434006435 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 478434006436 catalytic triad [active] 478434006437 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 478434006438 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 478434006439 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 478434006440 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 478434006441 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 478434006442 substrate binding site [chemical binding]; other site 478434006443 glutamase interaction surface [polypeptide binding]; other site 478434006444 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 478434006445 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 478434006446 active site 478434006447 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 478434006448 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 478434006449 catalytic residues [active] 478434006450 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 478434006451 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 478434006452 putative active site [active] 478434006453 oxyanion strand; other site 478434006454 catalytic triad [active] 478434006455 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 478434006456 4-fold oligomerization interface [polypeptide binding]; other site 478434006457 putative active site pocket [active] 478434006458 metal binding residues [ion binding]; metal-binding site 478434006459 3-fold/trimer interface [polypeptide binding]; other site 478434006460 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 478434006461 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 478434006462 pyridoxal 5'-phosphate binding site [chemical binding]; other site 478434006463 homodimer interface [polypeptide binding]; other site 478434006464 catalytic residue [active] 478434006465 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 478434006466 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 478434006467 NAD binding site [chemical binding]; other site 478434006468 dimerization interface [polypeptide binding]; other site 478434006469 product binding site; other site 478434006470 substrate binding site [chemical binding]; other site 478434006471 zinc binding site [ion binding]; other site 478434006472 catalytic residues [active] 478434006473 deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026 478434006474 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478434006475 S-adenosylmethionine binding site [chemical binding]; other site 478434006476 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 478434006477 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 478434006478 dimerization interface [polypeptide binding]; other site 478434006479 active site 478434006480 L-aspartate oxidase; Provisional; Region: PRK07804 478434006481 L-aspartate oxidase; Provisional; Region: PRK06175 478434006482 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 478434006483 quinolinate synthetase; Provisional; Region: PRK09375 478434006484 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 478434006485 nudix motif; other site 478434006486 Secretory lipase; Region: LIP; pfam03583 478434006487 Protein of unknown function (DUF2567); Region: DUF2567; pfam10821 478434006488 biotin synthase; Validated; Region: PRK06256 478434006489 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 478434006490 FeS/SAM binding site; other site 478434006491 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 478434006492 Domain of unknown function (DUF222); Region: DUF222; pfam02720 478434006493 Domain of unknown function (DUF222); Region: DUF222; pfam02720 478434006494 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 478434006495 active site 478434006496 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 478434006497 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 478434006498 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 478434006499 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 478434006500 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 478434006501 catalytic residue [active] 478434006502 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 478434006503 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 478434006504 inhibitor-cofactor binding pocket; inhibition site 478434006505 pyridoxal 5'-phosphate binding site [chemical binding]; other site 478434006506 catalytic residue [active] 478434006507 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 478434006508 NlpC/P60 family; Region: NLPC_P60; pfam00877 478434006509 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 478434006510 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 478434006511 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 478434006512 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 478434006513 active site 478434006514 catalytic site [active] 478434006515 malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401 478434006516 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 478434006517 active site 478434006518 catalytic site [active] 478434006519 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 478434006520 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 478434006521 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 478434006522 catalytic site [active] 478434006523 active site 478434006524 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 478434006525 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 478434006526 putative active site [active] 478434006527 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 478434006528 threonine dehydratase; Validated; Region: PRK08639 478434006529 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 478434006530 tetramer interface [polypeptide binding]; other site 478434006531 pyridoxal 5'-phosphate binding site [chemical binding]; other site 478434006532 catalytic residue [active] 478434006533 C-terminal regulatory domain of Threonine dehydratase; Region: Thr_dehydrat_C; pfam00585 478434006534 Domain of unknown function (DUF385); Region: DUF385; pfam04075 478434006535 MMPL family; Region: MMPL; pfam03176 478434006536 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 478434006537 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478434006538 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 478434006539 Iron-sulfur protein interface; other site 478434006540 proximal quinone binding site [chemical binding]; other site 478434006541 C-subunit interface; other site 478434006542 distal quinone binding site; other site 478434006543 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 478434006544 D-subunit interface [polypeptide binding]; other site 478434006545 Iron-sulfur protein interface; other site 478434006546 proximal quinone binding site [chemical binding]; other site 478434006547 distal quinone binding site [chemical binding]; other site 478434006548 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 478434006549 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 478434006550 fumarate reductase, flavoprotein subunit; Region: fum_red_Fp; TIGR01176 478434006551 L-aspartate oxidase; Provisional; Region: PRK06175 478434006552 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 478434006553 glycerol-3-phosphate acyltransferase; Reviewed; Region: PRK11915 478434006554 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 478434006555 putative acyl-acceptor binding pocket; other site 478434006556 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 478434006557 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 478434006558 acyl-activating enzyme (AAE) consensus motif; other site 478434006559 putative AMP binding site [chemical binding]; other site 478434006560 putative active site [active] 478434006561 putative CoA binding site [chemical binding]; other site 478434006562 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478434006563 PPE family; Region: PPE; pfam00823 478434006564 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478434006565 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478434006566 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 478434006567 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 478434006568 active site 478434006569 PHP Thumb interface [polypeptide binding]; other site 478434006570 metal binding site [ion binding]; metal-binding site 478434006571 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 478434006572 generic binding surface II; other site 478434006573 generic binding surface I; other site 478434006574 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 478434006575 hydrophobic ligand binding site; other site 478434006576 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 478434006577 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 478434006578 NAD(P) binding site [chemical binding]; other site 478434006579 active site 478434006580 short chain dehydrogenase; Provisional; Region: PRK05866 478434006581 classical (c) SDRs; Region: SDR_c; cd05233 478434006582 NAD(P) binding site [chemical binding]; other site 478434006583 active site 478434006584 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 478434006585 apolar tunnel; other site 478434006586 heme binding site [chemical binding]; other site 478434006587 dimerization interface [polypeptide binding]; other site 478434006588 Uncharacterized protein conserved in bacteria, putative lipoprotein [Function unknown]; Region: LprI; COG4461 478434006589 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 478434006590 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 478434006591 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 478434006592 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 478434006593 active site 478434006594 lipoprotein signal peptidase; Provisional; Region: PRK14764 478434006595 lipoprotein signal peptidase; Provisional; Region: PRK14787 478434006596 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 478434006597 active site 478434006598 homodimer interface [polypeptide binding]; other site 478434006599 homotetramer interface [polypeptide binding]; other site 478434006600 DNA polymerase IV; Provisional; Region: PRK03348 478434006601 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 478434006602 active site 478434006603 DNA binding site [nucleotide binding] 478434006604 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 478434006605 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 478434006606 HIGH motif; other site 478434006607 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 478434006608 active site 478434006609 KMSKS motif; other site 478434006610 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 478434006611 tRNA binding surface [nucleotide binding]; other site 478434006612 anticodon binding site; other site 478434006613 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478434006614 Nitronate monooxygenase; Region: NMO; pfam03060 478434006615 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 478434006616 FMN binding site [chemical binding]; other site 478434006617 substrate binding site [chemical binding]; other site 478434006618 putative catalytic residue [active] 478434006619 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 478434006620 CoenzymeA binding site [chemical binding]; other site 478434006621 subunit interaction site [polypeptide binding]; other site 478434006622 PHB binding site; other site 478434006623 Uncharacterized conserved protein [Function unknown]; Region: COG2128 478434006624 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 478434006625 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 478434006626 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 478434006627 NAD(P) binding site [chemical binding]; other site 478434006628 acyl-CoA synthetase; Validated; Region: PRK05850 478434006629 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 478434006630 acyl-activating enzyme (AAE) consensus motif; other site 478434006631 active site 478434006632 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 478434006633 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 478434006634 active site 478434006635 Acyl transferase domain; Region: Acyl_transf_1; pfam00698 478434006636 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 478434006637 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 478434006638 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 478434006639 Enoylreductase; Region: PKS_ER; smart00829 478434006640 NAD(P) binding site [chemical binding]; other site 478434006641 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 478434006642 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 478434006643 putative NADP binding site [chemical binding]; other site 478434006644 active site 478434006645 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 478434006646 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 478434006647 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 478434006648 homodimer interface [polypeptide binding]; other site 478434006649 active site 478434006650 TDP-binding site; other site 478434006651 acceptor substrate-binding pocket; other site 478434006652 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 478434006653 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 478434006654 Probable Catalytic site; other site 478434006655 metal-binding site 478434006656 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 478434006657 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 478434006658 homodimer interface [polypeptide binding]; other site 478434006659 active site 478434006660 TDP-binding site; other site 478434006661 acceptor substrate-binding pocket; other site 478434006662 Methyltransferase domain; Region: Methyltransf_23; pfam13489 478434006663 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478434006664 S-adenosylmethionine binding site [chemical binding]; other site 478434006665 Transport protein; Region: actII; TIGR00833 478434006666 acyl-CoA synthetase; Validated; Region: PRK05850 478434006667 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 478434006668 acyl-activating enzyme (AAE) consensus motif; other site 478434006669 active site 478434006670 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 478434006671 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 478434006672 active site 478434006673 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 478434006674 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 478434006675 active site 478434006676 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 478434006677 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 478434006678 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 478434006679 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 478434006680 active site 478434006681 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478434006682 S-adenosylmethionine binding site [chemical binding]; other site 478434006683 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 478434006684 metal-binding site 478434006685 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 478434006686 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 478434006687 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 478434006688 NADP binding site [chemical binding]; other site 478434006689 active site 478434006690 putative substrate binding site [chemical binding]; other site 478434006691 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 478434006692 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 478434006693 NADP-binding site; other site 478434006694 homotetramer interface [polypeptide binding]; other site 478434006695 substrate binding site [chemical binding]; other site 478434006696 homodimer interface [polypeptide binding]; other site 478434006697 active site 478434006698 Methyltransferase domain; Region: Methyltransf_23; pfam13489 478434006699 Methyltransferase domain; Region: Methyltransf_12; pfam08242 478434006700 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 478434006701 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 478434006702 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 478434006703 WbqC-like protein family; Region: WbqC; pfam08889 478434006704 Methyltransferase domain; Region: Methyltransf_12; pfam08242 478434006705 S-adenosylmethionine binding site [chemical binding]; other site 478434006706 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 478434006707 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 478434006708 putative trimer interface [polypeptide binding]; other site 478434006709 putative CoA binding site [chemical binding]; other site 478434006710 potential frameshift: common BLAST hit: gi|224989911|ref|YP_002644598.1| TDP-4-oxo-6-deoxy-D-glucose transaminase 478434006711 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 478434006712 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 478434006713 inhibitor-cofactor binding pocket; inhibition site 478434006714 pyridoxal 5'-phosphate binding site [chemical binding]; other site 478434006715 catalytic residue [active] 478434006716 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 478434006717 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 478434006718 Glycosyl hydrolase families 32 and 68, which for the clan GH-J; Region: GH_J; cd08979 478434006719 active site 478434006720 Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5285 478434006721 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 478434006722 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 478434006723 Ligand binding site; other site 478434006724 Putative Catalytic site; other site 478434006725 DXD motif; other site 478434006726 Uncharacterized conserved protein [Function unknown]; Region: COG3360 478434006727 Methyltransferase domain; Region: Methyltransf_31; pfam13847 478434006728 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478434006729 S-adenosylmethionine binding site [chemical binding]; other site 478434006730 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 478434006731 Beta-lactamase; Region: Beta-lactamase; pfam00144 478434006732 membrane ATPase/protein kinase; Provisional; Region: PRK09435 478434006733 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 478434006734 Walker A; other site 478434006735 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 478434006736 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 478434006737 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 478434006738 active site 478434006739 substrate binding site [chemical binding]; other site 478434006740 coenzyme B12 binding site [chemical binding]; other site 478434006741 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 478434006742 B12 binding site [chemical binding]; other site 478434006743 cobalt ligand [ion binding]; other site 478434006744 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 478434006745 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 478434006746 heterodimer interface [polypeptide binding]; other site 478434006747 substrate interaction site [chemical binding]; other site 478434006748 Methylmalonyl-CoA mutase, C-terminal domain/subunit (cobalamin-binding) [Lipid metabolism]; Region: Sbm; COG2185 478434006749 Uncharacterized conserved protein [Function unknown]; Region: COG0398 478434006750 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 478434006751 Transposase domain (DUF772); Region: DUF772; pfam05598 478434006752 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 478434006753 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 478434006754 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 478434006755 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 478434006756 ferrochelatase; Reviewed; Region: hemH; PRK00035 478434006757 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 478434006758 C-terminal domain interface [polypeptide binding]; other site 478434006759 active site 478434006760 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 478434006761 active site 478434006762 N-terminal domain interface [polypeptide binding]; other site 478434006763 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 478434006764 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 478434006765 NAD binding site [chemical binding]; other site 478434006766 homotetramer interface [polypeptide binding]; other site 478434006767 homodimer interface [polypeptide binding]; other site 478434006768 substrate binding site [chemical binding]; other site 478434006769 active site 478434006770 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 478434006771 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 478434006772 NAD(P) binding site [chemical binding]; other site 478434006773 homotetramer interface [polypeptide binding]; other site 478434006774 homodimer interface [polypeptide binding]; other site 478434006775 active site 478434006776 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 478434006777 hypothetical protein; Provisional; Region: PRK13685 478434006778 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 478434006779 metal ion-dependent adhesion site (MIDAS); other site 478434006780 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 478434006781 Protein of unknown function DUF58; Region: DUF58; pfam01882 478434006782 MoxR-like ATPases [General function prediction only]; Region: COG0714 478434006783 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 478434006784 Walker A motif; other site 478434006785 ATP binding site [chemical binding]; other site 478434006786 Walker B motif; other site 478434006787 arginine finger; other site 478434006788 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 478434006789 NlpC/P60 family; Region: NLPC_P60; pfam00877 478434006790 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 478434006791 NlpC/P60 family; Region: NLPC_P60; pfam00877 478434006792 aconitate hydratase; Validated; Region: PRK09277 478434006793 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 478434006794 substrate binding site [chemical binding]; other site 478434006795 ligand binding site [chemical binding]; other site 478434006796 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 478434006797 substrate binding site [chemical binding]; other site 478434006798 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 478434006799 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478434006800 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 478434006801 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 478434006802 Walker A/P-loop; other site 478434006803 ATP binding site [chemical binding]; other site 478434006804 Q-loop/lid; other site 478434006805 ABC transporter signature motif; other site 478434006806 Walker B; other site 478434006807 D-loop; other site 478434006808 H-loop/switch region; other site 478434006809 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 478434006810 enoyl-CoA hydratase; Provisional; Region: PRK05864 478434006811 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 478434006812 substrate binding site [chemical binding]; other site 478434006813 oxyanion hole (OAH) forming residues; other site 478434006814 trimer interface [polypeptide binding]; other site 478434006815 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 478434006816 catalytic residues [active] 478434006817 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 478434006818 catalytic residues [active] 478434006819 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 478434006820 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 478434006821 PE family; Region: PE; pfam00934 478434006822 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 478434006823 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 478434006824 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 478434006825 active site 478434006826 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 478434006827 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 478434006828 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 478434006829 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 478434006830 trimerization site [polypeptide binding]; other site 478434006831 active site 478434006832 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 478434006833 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 478434006834 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 478434006835 catalytic residue [active] 478434006836 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 478434006837 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 478434006838 Walker A/P-loop; other site 478434006839 ATP binding site [chemical binding]; other site 478434006840 Q-loop/lid; other site 478434006841 ABC transporter signature motif; other site 478434006842 Walker B; other site 478434006843 D-loop; other site 478434006844 H-loop/switch region; other site 478434006845 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 478434006846 FeS assembly protein SufD; Region: sufD; TIGR01981 478434006847 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 478434006848 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 478434006849 protein-splicing catalytic site; other site 478434006850 thioester formation/cholesterol transfer; other site 478434006851 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 478434006852 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 478434006853 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 478434006854 Predicted transcriptional regulator [Transcription]; Region: COG2345 478434006855 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 478434006856 putative DNA binding site [nucleotide binding]; other site 478434006857 putative Zn2+ binding site [ion binding]; other site 478434006858 Transcriptional regulator PadR-like family; Region: PadR; cl17335 478434006859 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 478434006860 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 478434006861 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 478434006862 Walker A/P-loop; other site 478434006863 ATP binding site [chemical binding]; other site 478434006864 Q-loop/lid; other site 478434006865 ABC transporter signature motif; other site 478434006866 Walker B; other site 478434006867 D-loop; other site 478434006868 H-loop/switch region; other site 478434006869 ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025 478434006870 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 478434006871 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 478434006872 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 478434006873 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 478434006874 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 478434006875 NADP binding site [chemical binding]; other site 478434006876 dimer interface [polypeptide binding]; other site 478434006877 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 478434006878 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 478434006879 PE family; Region: PE; pfam00934 478434006880 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 478434006881 UbiA prenyltransferase family; Region: UbiA; pfam01040 478434006882 PE family; Region: PE; pfam00934 478434006883 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 478434006884 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 478434006885 TPP-binding site [chemical binding]; other site 478434006886 dimer interface [polypeptide binding]; other site 478434006887 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 478434006888 PYR/PP interface [polypeptide binding]; other site 478434006889 dimer interface [polypeptide binding]; other site 478434006890 TPP binding site [chemical binding]; other site 478434006891 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 478434006892 putative active site [active] 478434006893 transaldolase; Provisional; Region: PRK03903 478434006894 catalytic residue [active] 478434006895 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 478434006896 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 478434006897 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 478434006898 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 478434006899 Glucose-6-P dehydrogenase subunit [Carbohydrate transport and metabolism]; Region: COG3429 478434006900 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 478434006901 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 478434006902 putative active site [active] 478434006903 Proteins of 100 residues with WXG; Region: WXG100; cl02005 478434006904 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 478434006905 hydrophobic ligand binding site; other site 478434006906 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 478434006907 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 478434006908 molybdopterin cofactor binding site [chemical binding]; other site 478434006909 substrate binding site [chemical binding]; other site 478434006910 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 478434006911 molybdopterin cofactor binding site; other site 478434006912 PE family; Region: PE; pfam00934 478434006913 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 478434006914 SnoaL-like domain; Region: SnoaL_2; pfam12680 478434006915 triosephosphate isomerase; Provisional; Region: PRK14567 478434006916 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 478434006917 substrate binding site [chemical binding]; other site 478434006918 dimer interface [polypeptide binding]; other site 478434006919 catalytic triad [active] 478434006920 Phosphoglycerate kinase; Region: PGK; pfam00162 478434006921 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 478434006922 substrate binding site [chemical binding]; other site 478434006923 hinge regions; other site 478434006924 ADP binding site [chemical binding]; other site 478434006925 catalytic site [active] 478434006926 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 478434006927 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 478434006928 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 478434006929 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 478434006930 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 478434006931 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 478434006932 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 478434006933 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 478434006934 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 478434006935 PE family; Region: PE; pfam00934 478434006936 PE-PPE domain; Region: PE-PPE; pfam08237 478434006937 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 478434006938 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 478434006939 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 478434006940 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 478434006941 putative acyl-acceptor binding pocket; other site 478434006942 acyl-CoA synthetase; Provisional; Region: PRK13382 478434006943 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 478434006944 acyl-activating enzyme (AAE) consensus motif; other site 478434006945 putative AMP binding site [chemical binding]; other site 478434006946 putative active site [active] 478434006947 putative CoA binding site [chemical binding]; other site 478434006948 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 478434006949 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 478434006950 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 478434006951 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 478434006952 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 478434006953 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 478434006954 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 478434006955 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 478434006956 phosphate binding site [ion binding]; other site 478434006957 putative substrate binding pocket [chemical binding]; other site 478434006958 dimer interface [polypeptide binding]; other site 478434006959 P-loop ATPase protein family; Region: ATP_bind_2; pfam03668 478434006960 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 478434006961 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 478434006962 GIY-YIG motif/motif A; other site 478434006963 active site 478434006964 catalytic site [active] 478434006965 putative DNA binding site [nucleotide binding]; other site 478434006966 metal binding site [ion binding]; metal-binding site 478434006967 UvrB/uvrC motif; Region: UVR; pfam02151 478434006968 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 478434006969 Helix-hairpin-helix motif; Region: HHH; pfam00633 478434006970 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 478434006971 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 478434006972 putative sugar binding sites [chemical binding]; other site 478434006973 Q-X-W motif; other site 478434006974 PknH-like extracellular domain; Region: PknH_C; pfam14032 478434006975 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 478434006976 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 478434006977 homopentamer interface [polypeptide binding]; other site 478434006978 active site 478434006979 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 478434006980 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 478434006981 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 478434006982 dimerization interface [polypeptide binding]; other site 478434006983 active site 478434006984 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 478434006985 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 478434006986 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 478434006987 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 478434006988 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 478434006989 Lumazine binding domain; Region: Lum_binding; pfam00677 478434006990 Lumazine binding domain; Region: Lum_binding; pfam00677 478434006991 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 478434006992 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 478434006993 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 478434006994 putative substrate translocation pore; other site 478434006995 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 478434006996 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 478434006997 catalytic motif [active] 478434006998 Zn binding site [ion binding]; other site 478434006999 RibD C-terminal domain; Region: RibD_C; pfam01872 478434007000 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 478434007001 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 478434007002 substrate binding site [chemical binding]; other site 478434007003 hexamer interface [polypeptide binding]; other site 478434007004 metal binding site [ion binding]; metal-binding site 478434007005 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 478434007006 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 478434007007 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 478434007008 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 478434007009 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 478434007010 putative active site [active] 478434007011 substrate binding site [chemical binding]; other site 478434007012 putative cosubstrate binding site; other site 478434007013 catalytic site [active] 478434007014 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 478434007015 substrate binding site [chemical binding]; other site 478434007016 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478434007017 S-adenosylmethionine binding site [chemical binding]; other site 478434007018 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 478434007019 MarR family; Region: MarR; pfam01047 478434007020 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478434007021 S-adenosylmethionine binding site [chemical binding]; other site 478434007022 primosome assembly protein PriA; Provisional; Region: PRK14873 478434007023 Predicted membrane protein [Function unknown]; Region: COG3714 478434007024 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 478434007025 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 478434007026 substrate binding pocket [chemical binding]; other site 478434007027 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 478434007028 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 478434007029 substrate binding pocket [chemical binding]; other site 478434007030 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 478434007031 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 478434007032 oligomeric interface; other site 478434007033 putative active site [active] 478434007034 homodimer interface [polypeptide binding]; other site 478434007035 PE family; Region: PE; pfam00934 478434007036 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 478434007037 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 478434007038 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 478434007039 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 478434007040 Cytochrome P450; Region: p450; cl12078 478434007041 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 478434007042 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 478434007043 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 478434007044 S-adenosylmethionine synthetase; Validated; Region: PRK05250 478434007045 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 478434007046 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 478434007047 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 478434007048 Flavoprotein; Region: Flavoprotein; pfam02441 478434007049 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 478434007050 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 478434007051 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 478434007052 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 478434007053 catalytic site [active] 478434007054 G-X2-G-X-G-K; other site 478434007055 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478434007056 PPE family; Region: PPE; pfam00823 478434007057 PE family; Region: PE; pfam00934 478434007058 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 478434007059 active site 478434007060 dimer interface [polypeptide binding]; other site 478434007061 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 478434007062 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 478434007063 ATP-grasp domain; Region: ATP-grasp_4; cl17255 478434007064 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 478434007065 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 478434007066 ATP-grasp domain; Region: ATP-grasp_4; cl17255 478434007067 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 478434007068 IMP binding site; other site 478434007069 dimer interface [polypeptide binding]; other site 478434007070 interdomain contacts; other site 478434007071 partial ornithine binding site; other site 478434007072 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 478434007073 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 478434007074 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 478434007075 catalytic site [active] 478434007076 subunit interface [polypeptide binding]; other site 478434007077 dihydroorotase; Validated; Region: pyrC; PRK09357 478434007078 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 478434007079 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 478434007080 active site 478434007081 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 478434007082 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 478434007083 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 478434007084 bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; Provisional; Region: PRK05205 478434007085 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 478434007086 Domain of unknown function (DUF222); Region: DUF222; pfam02720 478434007087 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 478434007088 active site 478434007089 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478434007090 S-adenosylmethionine binding site [chemical binding]; other site 478434007091 Uncharacterized conserved protein [Function unknown]; Region: COG3482 478434007092 uncharacterized domain; Region: TIGR00702 478434007093 YcaO-like family; Region: YcaO; pfam02624 478434007094 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 478434007095 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 478434007096 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 478434007097 malonyl-CoA binding site [chemical binding]; other site 478434007098 dimer interface [polypeptide binding]; other site 478434007099 active site 478434007100 product binding site; other site 478434007101 Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; pfam00173 478434007102 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 478434007103 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 478434007104 putative di-iron ligands [ion binding]; other site 478434007105 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 478434007106 Beta-lactamase; Region: Beta-lactamase; pfam00144 478434007107 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 478434007108 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 478434007109 synthetase active site [active] 478434007110 NTP binding site [chemical binding]; other site 478434007111 metal binding site [ion binding]; metal-binding site 478434007112 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 478434007113 anti sigma factor interaction site; other site 478434007114 regulatory phosphorylation site [posttranslational modification]; other site 478434007115 PAS fold; Region: PAS_4; pfam08448 478434007116 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 478434007117 putative active site [active] 478434007118 heme pocket [chemical binding]; other site 478434007119 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 478434007120 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 478434007121 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 478434007122 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 478434007123 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 478434007124 anti sigma factor interaction site; other site 478434007125 regulatory phosphorylation site [posttranslational modification]; other site 478434007126 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478434007127 PPE family; Region: PPE; pfam00823 478434007128 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 478434007129 probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841 478434007130 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 478434007131 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 478434007132 cyclase homology domain; Region: CHD; cd07302 478434007133 Predicted ATPase [General function prediction only]; Region: COG3903 478434007134 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 478434007135 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 478434007136 DNA binding residues [nucleotide binding] 478434007137 dimerization interface [polypeptide binding]; other site 478434007138 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 478434007139 cyclase homology domain; Region: CHD; cd07302 478434007140 nucleotidyl binding site; other site 478434007141 dimer interface [polypeptide binding]; other site 478434007142 metal binding site [ion binding]; metal-binding site 478434007143 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 478434007144 hypothetical protein; Provisional; Region: PRK07877 478434007145 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 478434007146 ATP binding site [chemical binding]; other site 478434007147 substrate interface [chemical binding]; other site 478434007148 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 478434007149 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 478434007150 GAF domain; Region: GAF; pfam01590 478434007151 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 478434007152 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 478434007153 metal binding site [ion binding]; metal-binding site 478434007154 active site 478434007155 I-site; other site 478434007156 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 478434007157 tetracycline repressor protein TetR; Provisional; Region: PRK13756 478434007158 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478434007159 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 478434007160 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 478434007161 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 478434007162 NAD(P) binding site [chemical binding]; other site 478434007163 active site 478434007164 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 478434007165 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 478434007166 Walker A/P-loop; other site 478434007167 ATP binding site [chemical binding]; other site 478434007168 Q-loop/lid; other site 478434007169 ABC transporter signature motif; other site 478434007170 Walker B; other site 478434007171 D-loop; other site 478434007172 H-loop/switch region; other site 478434007173 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 478434007174 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 478434007175 FAD binding pocket [chemical binding]; other site 478434007176 FAD binding motif [chemical binding]; other site 478434007177 phosphate binding motif [ion binding]; other site 478434007178 NAD binding pocket [chemical binding]; other site 478434007179 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 478434007180 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 478434007181 Walker A/P-loop; other site 478434007182 ATP binding site [chemical binding]; other site 478434007183 Q-loop/lid; other site 478434007184 ABC transporter signature motif; other site 478434007185 Walker B; other site 478434007186 D-loop; other site 478434007187 H-loop/switch region; other site 478434007188 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 478434007189 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 478434007190 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 478434007191 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 478434007192 active site 478434007193 long-chain-fatty-acid--[acyl-carrier-protein] ligase; Validated; Region: PRK05851 478434007194 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 478434007195 acyl-activating enzyme (AAE) consensus motif; other site 478434007196 active site 478434007197 acyl carrier protein; Validated; Region: PRK05883 478434007198 Glucitol operon activator [Transcription]; Region: GutM; COG4578 478434007199 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 478434007200 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 478434007201 active site 478434007202 dimerization interface [polypeptide binding]; other site 478434007203 ribonuclease PH; Reviewed; Region: rph; PRK00173 478434007204 Ribonuclease PH; Region: RNase_PH_bact; cd11362 478434007205 hexamer interface [polypeptide binding]; other site 478434007206 active site 478434007207 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 478434007208 glutamate racemase; Provisional; Region: PRK00865 478434007209 Rhomboid family; Region: Rhomboid; pfam01694 478434007210 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 478434007211 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 478434007212 dimer interface [polypeptide binding]; other site 478434007213 pyridoxal 5'-phosphate binding site [chemical binding]; other site 478434007214 catalytic residue [active] 478434007215 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 478434007216 MoaE interaction surface [polypeptide binding]; other site 478434007217 MoeB interaction surface [polypeptide binding]; other site 478434007218 thiocarboxylated glycine; other site 478434007219 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 478434007220 MPN+ (JAMM) motif; other site 478434007221 Zinc-binding site [ion binding]; other site 478434007222 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 478434007223 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 478434007224 putative active site pocket [active] 478434007225 cleavage site 478434007226 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 478434007227 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 478434007228 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 478434007229 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 478434007230 active site 478434007231 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 478434007232 DEAD/DEAH box helicase; Region: DEAD; pfam00270 478434007233 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 478434007234 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 478434007235 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 478434007236 putative homodimer interface [polypeptide binding]; other site 478434007237 putative active site pocket [active] 478434007238 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 478434007239 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 478434007240 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 478434007241 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 478434007242 active site 478434007243 homodimer interface [polypeptide binding]; other site 478434007244 catalytic site [active] 478434007245 acceptor binding site [chemical binding]; other site 478434007246 glycogen branching enzyme; Provisional; Region: PRK05402 478434007247 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 478434007248 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 478434007249 active site 478434007250 catalytic site [active] 478434007251 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 478434007252 PE family; Region: PE; pfam00934 478434007253 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 478434007254 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 478434007255 putative acyltransferase; Provisional; Region: PRK05790 478434007256 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 478434007257 dimer interface [polypeptide binding]; other site 478434007258 active site 478434007259 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 478434007260 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 478434007261 dimer interface [polypeptide binding]; other site 478434007262 substrate binding site [chemical binding]; other site 478434007263 metal binding site [ion binding]; metal-binding site 478434007264 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 478434007265 hypothetical protein; Provisional; Region: PRK03298 478434007266 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 478434007267 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 478434007268 dimerization interface [polypeptide binding]; other site 478434007269 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 478434007270 cyclase homology domain; Region: CHD; cd07302 478434007271 nucleotidyl binding site; other site 478434007272 metal binding site [ion binding]; metal-binding site 478434007273 dimer interface [polypeptide binding]; other site 478434007274 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 478434007275 dimerization interface [polypeptide binding]; other site 478434007276 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 478434007277 cyclase homology domain; Region: CHD; cd07302 478434007278 nucleotidyl binding site; other site 478434007279 metal binding site [ion binding]; metal-binding site 478434007280 dimer interface [polypeptide binding]; other site 478434007281 HAMP domain; Region: HAMP; pfam00672 478434007282 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 478434007283 cyclase homology domain; Region: CHD; cd07302 478434007284 nucleotidyl binding site; other site 478434007285 metal binding site [ion binding]; metal-binding site 478434007286 dimer interface [polypeptide binding]; other site 478434007287 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 478434007288 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 478434007289 AlkA N-terminal domain; Region: AlkA_N; pfam06029 478434007290 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 478434007291 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 478434007292 minor groove reading motif; other site 478434007293 helix-hairpin-helix signature motif; other site 478434007294 substrate binding pocket [chemical binding]; other site 478434007295 active site 478434007296 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 478434007297 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 478434007298 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 478434007299 DNA binding site [nucleotide binding] 478434007300 active site 478434007301 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 478434007302 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 478434007303 hinge; other site 478434007304 active site 478434007305 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 478434007306 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 478434007307 Transposase; Region: DDE_Tnp_ISL3; pfam01610 478434007308 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 478434007309 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 478434007310 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 478434007311 gamma subunit interface [polypeptide binding]; other site 478434007312 epsilon subunit interface [polypeptide binding]; other site 478434007313 LBP interface [polypeptide binding]; other site 478434007314 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 478434007315 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 478434007316 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 478434007317 alpha subunit interaction interface [polypeptide binding]; other site 478434007318 Walker A motif; other site 478434007319 ATP binding site [chemical binding]; other site 478434007320 Walker B motif; other site 478434007321 inhibitor binding site; inhibition site 478434007322 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 478434007323 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 478434007324 core domain interface [polypeptide binding]; other site 478434007325 delta subunit interface [polypeptide binding]; other site 478434007326 epsilon subunit interface [polypeptide binding]; other site 478434007327 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 478434007328 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 478434007329 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 478434007330 Walker A motif; other site 478434007331 ATP binding site [chemical binding]; other site 478434007332 Walker B motif; other site 478434007333 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 478434007334 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13428 478434007335 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 478434007336 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 478434007337 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 478434007338 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 478434007339 F0F1 ATP synthase subunit C; Validated; Region: PRK05880 478434007340 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 478434007341 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 478434007342 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 478434007343 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 478434007344 Mg++ binding site [ion binding]; other site 478434007345 putative catalytic motif [active] 478434007346 substrate binding site [chemical binding]; other site 478434007347 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 478434007348 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 478434007349 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478434007350 S-adenosylmethionine binding site [chemical binding]; other site 478434007351 peptide chain release factor 1; Region: prfA; TIGR00019 478434007352 This domain is found in peptide chain release factors; Region: PCRF; smart00937 478434007353 RF-1 domain; Region: RF-1; pfam00472 478434007354 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 478434007355 transcription termination factor Rho; Provisional; Region: PRK12678 478434007356 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 478434007357 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 478434007358 RNA binding site [nucleotide binding]; other site 478434007359 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 478434007360 multimer interface [polypeptide binding]; other site 478434007361 Walker A motif; other site 478434007362 ATP binding site [chemical binding]; other site 478434007363 Walker B motif; other site 478434007364 Homoserine kinase [Amino acid transport and metabolism]; Region: ThrB; COG0083 478434007365 threonine synthase; Reviewed; Region: PRK06721 478434007366 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 478434007367 homodimer interface [polypeptide binding]; other site 478434007368 pyridoxal 5'-phosphate binding site [chemical binding]; other site 478434007369 catalytic residue [active] 478434007370 homoserine dehydrogenase; Provisional; Region: PRK06349 478434007371 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 478434007372 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 478434007373 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 478434007374 diaminopimelate decarboxylase; Region: lysA; TIGR01048 478434007375 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 478434007376 active site 478434007377 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 478434007378 substrate binding site [chemical binding]; other site 478434007379 catalytic residues [active] 478434007380 dimer interface [polypeptide binding]; other site 478434007381 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 478434007382 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 478434007383 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 478434007384 active site 478434007385 HIGH motif; other site 478434007386 KMSK motif region; other site 478434007387 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 478434007388 tRNA binding surface [nucleotide binding]; other site 478434007389 anticodon binding site; other site 478434007390 Protein of unknown function (DUF732); Region: DUF732; pfam05305 478434007391 Predicted membrane protein [Function unknown]; Region: COG4325 478434007392 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 478434007393 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 478434007394 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 478434007395 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 478434007396 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 478434007397 Putative esterase; Region: Esterase; pfam00756 478434007398 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 478434007399 Rrf2 family protein; Region: rrf2_super; TIGR00738 478434007400 Transcriptional regulator; Region: Rrf2; pfam02082 478434007401 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 478434007402 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 478434007403 CysD dimerization site [polypeptide binding]; other site 478434007404 G1 box; other site 478434007405 putative GEF interaction site [polypeptide binding]; other site 478434007406 GTP/Mg2+ binding site [chemical binding]; other site 478434007407 Switch I region; other site 478434007408 G2 box; other site 478434007409 G3 box; other site 478434007410 Switch II region; other site 478434007411 G4 box; other site 478434007412 G5 box; other site 478434007413 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 478434007414 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 478434007415 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 478434007416 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 478434007417 Walker A/P-loop; other site 478434007418 ligand-binding site [chemical binding]; other site 478434007419 ATP binding site [chemical binding]; other site 478434007420 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 478434007421 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 478434007422 Active Sites [active] 478434007423 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 478434007424 active site clefts [active] 478434007425 zinc binding site [ion binding]; other site 478434007426 dimer interface [polypeptide binding]; other site 478434007427 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 478434007428 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 478434007429 dimer interface [polypeptide binding]; other site 478434007430 conserved gate region; other site 478434007431 putative PBP binding loops; other site 478434007432 ABC-ATPase subunit interface; other site 478434007433 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 478434007434 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 478434007435 dimer interface [polypeptide binding]; other site 478434007436 conserved gate region; other site 478434007437 putative PBP binding loops; other site 478434007438 ABC-ATPase subunit interface; other site 478434007439 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 478434007440 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 478434007441 Walker A/P-loop; other site 478434007442 ATP binding site [chemical binding]; other site 478434007443 Q-loop/lid; other site 478434007444 ABC transporter signature motif; other site 478434007445 Walker B; other site 478434007446 D-loop; other site 478434007447 H-loop/switch region; other site 478434007448 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 478434007449 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 478434007450 Walker A/P-loop; other site 478434007451 ATP binding site [chemical binding]; other site 478434007452 Q-loop/lid; other site 478434007453 ABC transporter signature motif; other site 478434007454 Walker B; other site 478434007455 D-loop; other site 478434007456 H-loop/switch region; other site 478434007457 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 478434007458 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 478434007459 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 478434007460 choline dehydrogenase; Validated; Region: PRK02106 478434007461 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 478434007462 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 478434007463 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 478434007464 Walker A/P-loop; other site 478434007465 ATP binding site [chemical binding]; other site 478434007466 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 478434007467 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 478434007468 active site 478434007469 metal binding site [ion binding]; metal-binding site 478434007470 DNA binding site [nucleotide binding] 478434007471 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 478434007472 catalytic core [active] 478434007473 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 478434007474 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 478434007475 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 478434007476 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 478434007477 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 478434007478 Walker A/P-loop; other site 478434007479 ATP binding site [chemical binding]; other site 478434007480 Q-loop/lid; other site 478434007481 ABC transporter signature motif; other site 478434007482 Walker B; other site 478434007483 D-loop; other site 478434007484 H-loop/switch region; other site 478434007485 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 478434007486 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 478434007487 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 478434007488 Walker A/P-loop; other site 478434007489 ATP binding site [chemical binding]; other site 478434007490 Q-loop/lid; other site 478434007491 ABC transporter signature motif; other site 478434007492 Walker B; other site 478434007493 D-loop; other site 478434007494 H-loop/switch region; other site 478434007495 Protein of unknown function (DUF732); Region: DUF732; pfam05305 478434007496 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 478434007497 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 478434007498 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 478434007499 putative active site [active] 478434007500 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 478434007501 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 478434007502 DNA binding site [nucleotide binding] 478434007503 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 478434007504 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 478434007505 phosphopeptide binding site; other site 478434007506 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 478434007507 Catalytic domain of Protein Kinases; Region: PKc; cd00180 478434007508 active site 478434007509 ATP binding site [chemical binding]; other site 478434007510 substrate binding site [chemical binding]; other site 478434007511 activation loop (A-loop); other site 478434007512 PknH-like extracellular domain; Region: PknH_C; pfam14032 478434007513 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 478434007514 cyclase homology domain; Region: CHD; cd07302 478434007515 nucleotidyl binding site; other site 478434007516 metal binding site [ion binding]; metal-binding site 478434007517 dimer interface [polypeptide binding]; other site 478434007518 amidase; Provisional; Region: PRK12470 478434007519 Amidase; Region: Amidase; pfam01425 478434007520 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 478434007521 HIT family signature motif; other site 478434007522 catalytic residue [active] 478434007523 Domain of unknown function (DUF385); Region: DUF385; pfam04075 478434007524 hypothetical protein; Validated; Region: PRK05868 478434007525 hypothetical protein; Provisional; Region: PRK07236 478434007526 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 478434007527 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 478434007528 Fe-S cluster binding site [ion binding]; other site 478434007529 DNA binding site [nucleotide binding] 478434007530 active site 478434007531 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 478434007532 H+ Antiporter protein; Region: 2A0121; TIGR00900 478434007533 putative substrate translocation pore; other site 478434007534 FAD binding domain; Region: FAD_binding_4; pfam01565 478434007535 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 478434007536 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 478434007537 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 478434007538 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478434007539 Acyltransferase family; Region: Acyl_transf_3; pfam01757 478434007540 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 478434007541 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 478434007542 ATP binding site [chemical binding]; other site 478434007543 Mg++ binding site [ion binding]; other site 478434007544 motif III; other site 478434007545 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 478434007546 nucleotide binding region [chemical binding]; other site 478434007547 ATP-binding site [chemical binding]; other site 478434007548 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 478434007549 putative RNA binding site [nucleotide binding]; other site 478434007550 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 478434007551 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 478434007552 RNase_H superfamily; Region: RNase_H_2; pfam13482 478434007553 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 478434007554 Part of AAA domain; Region: AAA_19; pfam13245 478434007555 AAA domain; Region: AAA_12; pfam13087 478434007556 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 478434007557 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 478434007558 putative substrate translocation pore; other site 478434007559 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 478434007560 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 478434007561 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 478434007562 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 478434007563 TPP-binding site [chemical binding]; other site 478434007564 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 478434007565 dimer interface [polypeptide binding]; other site 478434007566 PYR/PP interface [polypeptide binding]; other site 478434007567 TPP binding site [chemical binding]; other site 478434007568 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 478434007569 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 478434007570 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 478434007571 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 478434007572 NAD(P) binding site [chemical binding]; other site 478434007573 active site 478434007574 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 478434007575 PE family; Region: PE; pfam00934 478434007576 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 478434007577 malate dehydrogenase; Provisional; Region: PRK05442 478434007578 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 478434007579 NAD(P) binding site [chemical binding]; other site 478434007580 dimer interface [polypeptide binding]; other site 478434007581 malate binding site [chemical binding]; other site 478434007582 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 478434007583 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 478434007584 oligomer interface [polypeptide binding]; other site 478434007585 metal binding site [ion binding]; metal-binding site 478434007586 metal binding site [ion binding]; metal-binding site 478434007587 putative Cl binding site [ion binding]; other site 478434007588 basic sphincter; other site 478434007589 hydrophobic gate; other site 478434007590 periplasmic entrance; other site 478434007591 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 478434007592 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 478434007593 Walker A/P-loop; other site 478434007594 ATP binding site [chemical binding]; other site 478434007595 Q-loop/lid; other site 478434007596 ABC transporter signature motif; other site 478434007597 Walker B; other site 478434007598 D-loop; other site 478434007599 H-loop/switch region; other site 478434007600 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 478434007601 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 478434007602 dimer interface [polypeptide binding]; other site 478434007603 conserved gate region; other site 478434007604 ABC-ATPase subunit interface; other site 478434007605 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 478434007606 dimer interface [polypeptide binding]; other site 478434007607 conserved gate region; other site 478434007608 putative PBP binding loops; other site 478434007609 ABC-ATPase subunit interface; other site 478434007610 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 478434007611 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 478434007612 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 478434007613 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 478434007614 MgtE intracellular N domain; Region: MgtE_N; smart00924 478434007615 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 478434007616 Predicted membrane protein [Function unknown]; Region: COG4420 478434007617 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 478434007618 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 478434007619 N-acetyl-D-glucosamine binding site [chemical binding]; other site 478434007620 catalytic residue [active] 478434007621 Domain of unknown function DUF59; Region: DUF59; cl00941 478434007622 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 478434007623 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 478434007624 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 478434007625 Uncharacterized conserved protein [Function unknown]; Region: COG3402 478434007626 Predicted membrane protein [Function unknown]; Region: COG3428 478434007627 Bacterial PH domain; Region: DUF304; pfam03703 478434007628 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 478434007629 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 478434007630 active site 478434007631 motif I; other site 478434007632 motif II; other site 478434007633 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 478434007634 sec-independent translocase; Provisional; Region: PRK03100 478434007635 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 478434007636 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 478434007637 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 478434007638 protein binding site [polypeptide binding]; other site 478434007639 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647 478434007640 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 478434007641 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 478434007642 DNA binding residues [nucleotide binding] 478434007643 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 478434007644 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478434007645 S-adenosylmethionine binding site [chemical binding]; other site 478434007646 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478434007647 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 478434007648 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 478434007649 Walker A/P-loop; other site 478434007650 ATP binding site [chemical binding]; other site 478434007651 Q-loop/lid; other site 478434007652 ABC transporter signature motif; other site 478434007653 Walker B; other site 478434007654 D-loop; other site 478434007655 H-loop/switch region; other site 478434007656 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 478434007657 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 478434007658 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 478434007659 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 478434007660 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 478434007661 PE family; Region: PE; pfam00934 478434007662 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 478434007663 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 478434007664 ligand binding site; other site 478434007665 oligomer interface; other site 478434007666 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 478434007667 dimer interface [polypeptide binding]; other site 478434007668 N-terminal domain interface [polypeptide binding]; other site 478434007669 sulfate 1 binding site; other site 478434007670 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 478434007671 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 478434007672 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 478434007673 DNA-3-methyladenine glycosylase I; Region: tag; TIGR00624 478434007674 DivIVA domain; Region: DivI1A_domain; TIGR03544 478434007675 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 478434007676 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 478434007677 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 478434007678 substrate binding pocket [chemical binding]; other site 478434007679 long-chain-acyl-CoA synthetase; Validated; Region: PRK08279 478434007680 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 478434007681 acyl-activating enzyme (AAE) consensus motif; other site 478434007682 putative AMP binding site [chemical binding]; other site 478434007683 putative active site [active] 478434007684 putative CoA binding site [chemical binding]; other site 478434007685 TIGR00730 family protein; Region: TIGR00730 478434007686 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 478434007687 Walker A motif; other site 478434007688 ATP binding site [chemical binding]; other site 478434007689 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 478434007690 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 478434007691 metal binding site [ion binding]; metal-binding site 478434007692 putative dimer interface [polypeptide binding]; other site 478434007693 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 478434007694 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 478434007695 putative trimer interface [polypeptide binding]; other site 478434007696 putative CoA binding site [chemical binding]; other site 478434007697 metabolite-proton symporter; Region: 2A0106; TIGR00883 478434007698 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 478434007699 putative substrate translocation pore; other site 478434007700 Transposase, Mutator family; Region: Transposase_mut; pfam00872 478434007701 MULE transposase domain; Region: MULE; pfam10551 478434007702 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 478434007703 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 478434007704 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478434007705 PPE family; Region: PPE; pfam00823 478434007706 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 478434007707 PE family; Region: PE; pfam00934 478434007708 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 478434007709 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 478434007710 acyl-CoA synthetase; Validated; Region: PRK07787 478434007711 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 478434007712 acyl-activating enzyme (AAE) consensus motif; other site 478434007713 AMP binding site [chemical binding]; other site 478434007714 active site 478434007715 CoA binding site [chemical binding]; other site 478434007716 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 478434007717 PGAP1-like protein; Region: PGAP1; pfam07819 478434007718 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 478434007719 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 478434007720 haloalkane dehalogenase; Provisional; Region: PRK03204 478434007721 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 478434007722 catalytic site [active] 478434007723 RNA polymerase sigma factor SigI; Provisional; Region: sigI; PRK09635 478434007724 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 478434007725 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 478434007726 DNA binding residues [nucleotide binding] 478434007727 Proline dehydrogenase; Region: Pro_dh; pfam01619 478434007728 Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123 478434007729 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 478434007730 Glutamate binding site [chemical binding]; other site 478434007731 NAD binding site [chemical binding]; other site 478434007732 catalytic residues [active] 478434007733 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 478434007734 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 478434007735 acyl-CoA synthetase; Validated; Region: PRK05850 478434007736 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 478434007737 acyl-activating enzyme (AAE) consensus motif; other site 478434007738 active site 478434007739 PE-PPE domain; Region: PE-PPE; pfam08237 478434007740 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 478434007741 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 478434007742 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 478434007743 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 478434007744 active site 478434007745 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 478434007746 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 478434007747 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 478434007748 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 478434007749 Enoylreductase; Region: PKS_ER; smart00829 478434007750 NAD(P) binding site [chemical binding]; other site 478434007751 KR domain; Region: KR; pfam08659 478434007752 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 478434007753 putative NADP binding site [chemical binding]; other site 478434007754 active site 478434007755 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 478434007756 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 478434007757 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 478434007758 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 478434007759 ATP binding site [chemical binding]; other site 478434007760 putative Mg++ binding site [ion binding]; other site 478434007761 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 478434007762 ATP-binding site [chemical binding]; other site 478434007763 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 478434007764 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 478434007765 pyridoxal 5'-phosphate binding site [chemical binding]; other site 478434007766 homodimer interface [polypeptide binding]; other site 478434007767 catalytic residue [active] 478434007768 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 478434007769 4Fe-4S binding domain; Region: Fer4; pfam00037 478434007770 Predicted transcriptional regulators [Transcription]; Region: COG1695 478434007771 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 478434007772 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 478434007773 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 478434007774 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 478434007775 active site 478434007776 FMN binding site [chemical binding]; other site 478434007777 2,4-decadienoyl-CoA binding site; other site 478434007778 catalytic residue [active] 478434007779 4Fe-4S cluster binding site [ion binding]; other site 478434007780 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 478434007781 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 478434007782 FO synthase; Reviewed; Region: fbiC; PRK09234 478434007783 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 478434007784 FeS/SAM binding site; other site 478434007785 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 478434007786 FeS/SAM binding site; other site 478434007787 PE family; Region: PE; pfam00934 478434007788 N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D- glucopyranoside deacetylase; Region: mycothiol_MshB; TIGR03445 478434007789 PE family; Region: PE; pfam00934 478434007790 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478434007791 PPE family; Region: PPE; pfam00823 478434007792 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 478434007793 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 478434007794 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478434007795 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 478434007796 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 478434007797 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 478434007798 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 478434007799 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 478434007800 G1 box; other site 478434007801 putative GEF interaction site [polypeptide binding]; other site 478434007802 GTP/Mg2+ binding site [chemical binding]; other site 478434007803 Switch I region; other site 478434007804 G2 box; other site 478434007805 G3 box; other site 478434007806 Switch II region; other site 478434007807 G4 box; other site 478434007808 G5 box; other site 478434007809 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 478434007810 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 478434007811 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 478434007812 nitrate reductase molybdenum cofactor assembly chaperone; Region: narJ; TIGR00684 478434007813 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 478434007814 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 478434007815 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 478434007816 [4Fe-4S] binding site [ion binding]; other site 478434007817 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 478434007818 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 478434007819 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 478434007820 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 478434007821 molybdopterin cofactor binding site; other site 478434007822 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 478434007823 active site 478434007824 8-oxo-dGMP binding site [chemical binding]; other site 478434007825 nudix motif; other site 478434007826 metal binding site [ion binding]; metal-binding site 478434007827 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 478434007828 aromatic arch; other site 478434007829 DCoH dimer interaction site [polypeptide binding]; other site 478434007830 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 478434007831 DCoH tetramer interaction site [polypeptide binding]; other site 478434007832 substrate binding site [chemical binding]; other site 478434007833 mannosyltransferase; Provisional; Region: pimE; PRK13375 478434007834 uncharacterized HhH-GPD family protein; Region: TIGR03252 478434007835 minor groove reading motif; other site 478434007836 helix-hairpin-helix signature motif; other site 478434007837 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 478434007838 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797 478434007839 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 478434007840 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 478434007841 Predicted transcriptional regulators [Transcription]; Region: COG1725 478434007842 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 478434007843 DNA-binding site [nucleotide binding]; DNA binding site 478434007844 NAD-dependent deacetylase; Provisional; Region: PRK00481 478434007845 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 478434007846 NAD+ binding site [chemical binding]; other site 478434007847 substrate binding site [chemical binding]; other site 478434007848 Zn binding site [ion binding]; other site 478434007849 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 478434007850 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 478434007851 Domain of unknown function (DUF222); Region: DUF222; pfam02720 478434007852 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 478434007853 active site 478434007854 DDE superfamily endonuclease; Region: DDE_5; cl17874 478434007855 MMPL family; Region: MMPL; pfam03176 478434007856 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 478434007857 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 478434007858 NAD binding site [chemical binding]; other site 478434007859 homodimer interface [polypeptide binding]; other site 478434007860 homotetramer interface [polypeptide binding]; other site 478434007861 active site 478434007862 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 478434007863 CoA-transferase family III; Region: CoA_transf_3; pfam02515 478434007864 enoyl-CoA hydratase; Provisional; Region: PRK06688 478434007865 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 478434007866 substrate binding site [chemical binding]; other site 478434007867 oxyanion hole (OAH) forming residues; other site 478434007868 trimer interface [polypeptide binding]; other site 478434007869 enoyl-CoA hydratase; Provisional; Region: PRK06688 478434007870 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 478434007871 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 478434007872 trimer interface [polypeptide binding]; other site 478434007873 CAAX protease self-immunity; Region: Abi; pfam02517 478434007874 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 478434007875 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 478434007876 enoyl-CoA hydratase; Provisional; Region: PRK06494 478434007877 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 478434007878 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 478434007879 substrate binding site [chemical binding]; other site 478434007880 oxyanion hole (OAH) forming residues; other site 478434007881 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 478434007882 active site 478434007883 PPE family; Region: PPE; pfam00823 478434007884 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478434007885 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 478434007886 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 478434007887 THF binding site; other site 478434007888 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 478434007889 substrate binding site [chemical binding]; other site 478434007890 THF binding site; other site 478434007891 zinc-binding site [ion binding]; other site 478434007892 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 478434007893 citrate synthase; Provisional; Region: PRK14033 478434007894 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 478434007895 oxalacetate binding site [chemical binding]; other site 478434007896 citrylCoA binding site [chemical binding]; other site 478434007897 coenzyme A binding site [chemical binding]; other site 478434007898 catalytic triad [active] 478434007899 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 478434007900 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 478434007901 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 478434007902 non-specific DNA binding site [nucleotide binding]; other site 478434007903 salt bridge; other site 478434007904 sequence-specific DNA binding site [nucleotide binding]; other site 478434007905 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 478434007906 Domain of unknown function (DUF955); Region: DUF955; pfam06114 478434007907 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 478434007908 Domain of unknown function (DUF222); Region: DUF222; pfam02720 478434007909 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 478434007910 active site 478434007911 pyruvate phosphate dikinase; Provisional; Region: PRK05878 478434007912 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 478434007913 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700 478434007914 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 478434007915 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 478434007916 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 478434007917 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 478434007918 6-phosphogluconate dehydrogenase (decarboxylating); Region: gnd_rel; TIGR00872 478434007919 glucose-6-phosphate 1-dehydrogenase; Region: zwf; TIGR00871 478434007920 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 478434007921 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 478434007922 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 478434007923 cyclase homology domain; Region: CHD; cd07302 478434007924 nucleotidyl binding site; other site 478434007925 metal binding site [ion binding]; metal-binding site 478434007926 dimer interface [polypeptide binding]; other site 478434007927 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 478434007928 Uncharacterized conserved protein [Function unknown]; Region: COG1359 478434007929 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: VapC; COG1487 478434007930 putative active site [active] 478434007931 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 478434007932 GTP-binding protein YchF; Reviewed; Region: PRK09601 478434007933 YchF GTPase; Region: YchF; cd01900 478434007934 G1 box; other site 478434007935 GTP/Mg2+ binding site [chemical binding]; other site 478434007936 Switch I region; other site 478434007937 G2 box; other site 478434007938 Switch II region; other site 478434007939 G3 box; other site 478434007940 G4 box; other site 478434007941 G5 box; other site 478434007942 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 478434007943 Yip1 domain; Region: Yip1; pfam04893 478434007944 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 478434007945 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 478434007946 Exonuclease VII, large subunit [DNA replication, recombination, and repair]; Region: XseA; COG1570 478434007947 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 478434007948 generic binding surface II; other site 478434007949 generic binding surface I; other site 478434007950 exodeoxyribonuclease VII, small subunit; Region: xseB; TIGR01280 478434007951 3beta-hydroxysteroid dehydrogenases (3b-HSD)-like, extended (e) SDRs; Region: 3b-HSD-like_SDR_e; cd05241 478434007952 3-beta hydroxysteroid dehydrogenase/isomerase family; Region: 3Beta_HSD; pfam01073 478434007953 putative NAD(P) binding site [chemical binding]; other site 478434007954 active site 478434007955 putative substrate binding site [chemical binding]; other site 478434007956 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 478434007957 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 478434007958 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 478434007959 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 478434007960 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 478434007961 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 478434007962 Domain of unknown function DUF20; Region: UPF0118; pfam01594 478434007963 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 478434007964 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 478434007965 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 478434007966 putative active site [active] 478434007967 fumarate hydratase; Reviewed; Region: fumC; PRK00485 478434007968 Class II fumarases; Region: Fumarase_classII; cd01362 478434007969 active site 478434007970 tetramer interface [polypeptide binding]; other site 478434007971 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 478434007972 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 478434007973 NodB motif; other site 478434007974 active site 478434007975 catalytic site [active] 478434007976 metal binding site [ion binding]; metal-binding site 478434007977 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 478434007978 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 478434007979 putative active site [active] 478434007980 PhoH-like protein; Region: PhoH; pfam02562 478434007981 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 478434007982 dinuclear metal binding motif [ion binding]; other site 478434007983 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 478434007984 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 478434007985 dimer interface [polypeptide binding]; other site 478434007986 active site 478434007987 glycine-pyridoxal phosphate binding site [chemical binding]; other site 478434007988 folate binding site [chemical binding]; other site 478434007989 pantothenate kinase; Provisional; Region: PRK05439 478434007990 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 478434007991 ATP-binding site [chemical binding]; other site 478434007992 CoA-binding site [chemical binding]; other site 478434007993 Mg2+-binding site [ion binding]; other site 478434007994 PE family; Region: PE; pfam00934 478434007995 Glycosyl hydrolase family 12; Region: Glyco_hydro_12; pfam01670 478434007996 PE family; Region: PE; pfam00934 478434007997 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 478434007998 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 478434007999 putative IPP diphosphate binding site; other site 478434008000 PE family; Region: PE; pfam00934 478434008001 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 478434008002 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 478434008003 catalytic residue [active] 478434008004 putative FPP diphosphate binding site; other site 478434008005 putative FPP binding hydrophobic cleft; other site 478434008006 dimer interface [polypeptide binding]; other site 478434008007 putative IPP diphosphate binding site; other site 478434008008 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 478434008009 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 478434008010 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 478434008011 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 478434008012 catalytic residues [active] 478434008013 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 478434008014 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 478434008015 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 478434008016 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 478434008017 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 478434008018 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 478434008019 cystathionine gamma-synthase; Provisional; Region: PRK07811 478434008020 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 478434008021 homodimer interface [polypeptide binding]; other site 478434008022 substrate-cofactor binding pocket; other site 478434008023 pyridoxal 5'-phosphate binding site [chemical binding]; other site 478434008024 catalytic residue [active] 478434008025 RDD family; Region: RDD; pfam06271 478434008026 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 478434008027 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 478434008028 dimer interface [polypeptide binding]; other site 478434008029 pyridoxal 5'-phosphate binding site [chemical binding]; other site 478434008030 catalytic residue [active] 478434008031 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 478434008032 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 478434008033 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 478434008034 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 478434008035 active site 478434008036 catalytic triad [active] 478434008037 oxyanion hole [active] 478434008038 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 478434008039 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 478434008040 dimer interface [polypeptide binding]; other site 478434008041 active site 478434008042 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 478434008043 Predicted membrane protein [Function unknown]; Region: COG4760 478434008044 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 478434008045 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 478434008046 substrate binding site [chemical binding]; other site 478434008047 oxyanion hole (OAH) forming residues; other site 478434008048 trimer interface [polypeptide binding]; other site 478434008049 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 478434008050 enoyl-CoA hydratase; Provisional; Region: PRK05862 478434008051 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 478434008052 substrate binding site [chemical binding]; other site 478434008053 oxyanion hole (OAH) forming residues; other site 478434008054 trimer interface [polypeptide binding]; other site 478434008055 Predicted membrane protein [Function unknown]; Region: COG4425 478434008056 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 478434008057 PE family; Region: PE; pfam00934 478434008058 PE family; Region: PE; pfam00934 478434008059 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 478434008060 active site residue [active] 478434008061 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 478434008062 hypothetical protein; Provisional; Region: PRK10279 478434008063 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 478434008064 active site 478434008065 nucleophile elbow; other site 478434008066 Patatin-like phospholipase; Region: Patatin; pfam01734 478434008067 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 478434008068 nucleophile elbow; other site 478434008069 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 478434008070 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 478434008071 putative active site [active] 478434008072 putative dimer interface [polypeptide binding]; other site 478434008073 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 478434008074 hydrophobic ligand binding site; other site 478434008075 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 478434008076 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 478434008077 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 478434008078 dimer interface [polypeptide binding]; other site 478434008079 acyl-activating enzyme (AAE) consensus motif; other site 478434008080 putative active site [active] 478434008081 AMP binding site [chemical binding]; other site 478434008082 putative CoA binding site [chemical binding]; other site 478434008083 Uncharacterized conserved protein [Function unknown]; Region: COG3391 478434008084 Domain of unknown function (DUF222); Region: DUF222; pfam02720 478434008085 Domain of unknown function (DUF427); Region: DUF427; cl00998 478434008086 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 478434008087 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 478434008088 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 478434008089 Helix-turn-helix domain; Region: HTH_17; pfam12728 478434008090 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 478434008091 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 478434008092 NAD(P) binding site [chemical binding]; other site 478434008093 active site 478434008094 Transcriptional regulators [Transcription]; Region: MarR; COG1846 478434008095 MarR family; Region: MarR_2; pfam12802 478434008096 Transposase, Mutator family; Region: Transposase_mut; pfam00872 478434008097 MULE transposase domain; Region: MULE; pfam10551 478434008098 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 478434008099 Predicted transcriptional regulator [Transcription]; Region: COG5340 478434008100 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 478434008101 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 478434008102 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 478434008103 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 478434008104 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 478434008105 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 478434008106 PE family; Region: PE; pfam00934 478434008107 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 478434008108 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478434008109 PPE family; Region: PPE; pfam00823 478434008110 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 478434008111 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 478434008112 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 478434008113 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 478434008114 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 478434008115 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 478434008116 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 478434008117 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 478434008118 active site 478434008119 phosphorylation site [posttranslational modification] 478434008120 intermolecular recognition site; other site 478434008121 dimerization interface [polypeptide binding]; other site 478434008122 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 478434008123 DNA binding site [nucleotide binding] 478434008124 potential frameshift: common BLAST hit: gi|224989434|ref|YP_002644121.1| two component sensor histidine kinase 478434008125 sensor protein BasS/PmrB; Provisional; Region: PRK10755 478434008126 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 478434008127 ATP binding site [chemical binding]; other site 478434008128 Mg2+ binding site [ion binding]; other site 478434008129 G-X-G motif; other site 478434008130 potassium-transporting ATPase subunit C; Provisional; Region: PRK14001 478434008131 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 478434008132 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 478434008133 Soluble P-type ATPase [General function prediction only]; Region: COG4087 478434008134 K+-transporting ATPase, KdpA; Region: kdpA; TIGR00680 478434008135 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 478434008136 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 478434008137 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 478434008138 Ligand Binding Site [chemical binding]; other site 478434008139 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 478434008140 dimer interface [polypeptide binding]; other site 478434008141 phosphorylation site [posttranslational modification] 478434008142 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 478434008143 ATP binding site [chemical binding]; other site 478434008144 Mg2+ binding site [ion binding]; other site 478434008145 G-X-G motif; other site 478434008146 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 478434008147 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 478434008148 active site 478434008149 phosphorylation site [posttranslational modification] 478434008150 intermolecular recognition site; other site 478434008151 dimerization interface [polypeptide binding]; other site 478434008152 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 478434008153 DNA binding site [nucleotide binding] 478434008154 exopolyphosphatase; Region: exo_poly_only; TIGR03706 478434008155 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 478434008156 Uncharacterized conserved protein [Function unknown]; Region: COG1507 478434008157 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 478434008158 Septum formation initiator; Region: DivIC; pfam04977 478434008159 enolase; Provisional; Region: eno; PRK00077 478434008160 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 478434008161 dimer interface [polypeptide binding]; other site 478434008162 metal binding site [ion binding]; metal-binding site 478434008163 substrate binding pocket [chemical binding]; other site 478434008164 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 478434008165 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 478434008166 N-acetyl-D-glucosamine binding site [chemical binding]; other site 478434008167 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334 478434008168 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 478434008169 homodimer interface [polypeptide binding]; other site 478434008170 metal binding site [ion binding]; metal-binding site 478434008171 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 478434008172 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 478434008173 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 478434008174 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 478434008175 ATP binding site [chemical binding]; other site 478434008176 putative Mg++ binding site [ion binding]; other site 478434008177 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 478434008178 nucleotide binding region [chemical binding]; other site 478434008179 ATP-binding site [chemical binding]; other site 478434008180 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 478434008181 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 478434008182 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478434008183 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 478434008184 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 478434008185 Substrate binding site; other site 478434008186 Mg++ binding site; other site 478434008187 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 478434008188 active site 478434008189 substrate binding site [chemical binding]; other site 478434008190 CoA binding site [chemical binding]; other site 478434008191 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 478434008192 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 478434008193 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 478434008194 active site 478434008195 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 478434008196 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 478434008197 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 478434008198 5S rRNA interface [nucleotide binding]; other site 478434008199 CTC domain interface [polypeptide binding]; other site 478434008200 L16 interface [polypeptide binding]; other site 478434008201 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 478434008202 putative active site [active] 478434008203 catalytic residue [active] 478434008204 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 478434008205 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 478434008206 acyl-activating enzyme (AAE) consensus motif; other site 478434008207 AMP binding site [chemical binding]; other site 478434008208 active site 478434008209 CoA binding site [chemical binding]; other site 478434008210 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 478434008211 Increased loss of mitochondrial DNA protein 1; Region: Ilm1; pfam10311 478434008212 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 478434008213 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 478434008214 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478434008215 S-adenosylmethionine binding site [chemical binding]; other site 478434008216 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 478434008217 Domain of unknown function (DUF348); Region: DUF348; pfam03990 478434008218 Domain of unknown function (DUF348); Region: DUF348; pfam03990 478434008219 G5 domain; Region: G5; pfam07501 478434008220 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 478434008221 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 478434008222 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 478434008223 active site 478434008224 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 478434008225 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 478434008226 active site 478434008227 HIGH motif; other site 478434008228 KMSKS motif; other site 478434008229 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 478434008230 tRNA binding surface [nucleotide binding]; other site 478434008231 anticodon binding site; other site 478434008232 aminodeoxychorismate synthase component I; Provisional; Region: PRK05877 478434008233 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 478434008234 Predicted methyltransferases [General function prediction only]; Region: COG0313 478434008235 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 478434008236 putative SAM binding site [chemical binding]; other site 478434008237 putative homodimer interface [polypeptide binding]; other site 478434008238 Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928 478434008239 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 478434008240 arginine deiminase; Provisional; Region: PRK01388 478434008241 Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145 478434008242 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 478434008243 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 478434008244 ligand binding site [chemical binding]; other site 478434008245 flexible hinge region; other site 478434008246 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 478434008247 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 478434008248 Coenzyme A binding pocket [chemical binding]; other site 478434008249 potential frameshift: common BLAST hit: gi|183984467|ref|YP_001852758.1| methyltransferase 478434008250 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478434008251 S-adenosylmethionine binding site [chemical binding]; other site 478434008252 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 478434008253 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 478434008254 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 478434008255 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 478434008256 dimer interface [polypeptide binding]; other site 478434008257 putative functional site; other site 478434008258 putative MPT binding site; other site 478434008259 UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210 478434008260 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 478434008261 active site 478434008262 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 478434008263 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 478434008264 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2331 478434008265 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 478434008266 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 478434008267 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 478434008268 substrate binding pocket [chemical binding]; other site 478434008269 chain length determination region; other site 478434008270 substrate-Mg2+ binding site; other site 478434008271 catalytic residues [active] 478434008272 aspartate-rich region 1; other site 478434008273 active site lid residues [active] 478434008274 aspartate-rich region 2; other site 478434008275 Predicted secreted hydrolase [General function prediction only]; Region: COG5621 478434008276 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 478434008277 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 478434008278 FtsX-like permease family; Region: FtsX; pfam02687 478434008279 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 478434008280 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 478434008281 FtsX-like permease family; Region: FtsX; pfam02687 478434008282 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 478434008283 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 478434008284 Walker A/P-loop; other site 478434008285 ATP binding site [chemical binding]; other site 478434008286 Q-loop/lid; other site 478434008287 ABC transporter signature motif; other site 478434008288 Walker B; other site 478434008289 D-loop; other site 478434008290 H-loop/switch region; other site 478434008291 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 478434008292 Large-conductance mechanosensitive channel, MscL; Region: MscL; pfam01741 478434008293 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 478434008294 MPT binding site; other site 478434008295 trimer interface [polypeptide binding]; other site 478434008296 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 478434008297 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 478434008298 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 478434008299 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 478434008300 dimerization interface [polypeptide binding]; other site 478434008301 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 478434008302 dimer interface [polypeptide binding]; other site 478434008303 phosphorylation site [posttranslational modification] 478434008304 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 478434008305 ATP binding site [chemical binding]; other site 478434008306 Mg2+ binding site [ion binding]; other site 478434008307 G-X-G motif; other site 478434008308 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 478434008309 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 478434008310 active site 478434008311 phosphorylation site [posttranslational modification] 478434008312 intermolecular recognition site; other site 478434008313 dimerization interface [polypeptide binding]; other site 478434008314 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 478434008315 DNA binding site [nucleotide binding] 478434008316 PE family; Region: PE; pfam00934 478434008317 Uncharacterized conserved protein [Function unknown]; Region: COG3391 478434008318 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 478434008319 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 478434008320 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 478434008321 PE family; Region: PE; pfam00934 478434008322 Uncharacterized conserved protein [Function unknown]; Region: COG3391 478434008323 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 478434008324 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 478434008325 PE family; Region: PE; pfam00934 478434008326 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 478434008327 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 478434008328 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 478434008329 active site 478434008330 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 478434008331 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 478434008332 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 478434008333 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 478434008334 ATP-grasp domain; Region: ATP-grasp_4; cl17255 478434008335 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 478434008336 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 478434008337 carboxyltransferase (CT) interaction site; other site 478434008338 biotinylation site [posttranslational modification]; other site 478434008339 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 478434008340 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 478434008341 active site 478434008342 enoyl-CoA hydratase; Provisional; Region: PRK07827 478434008343 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 478434008344 substrate binding site [chemical binding]; other site 478434008345 oxyanion hole (OAH) forming residues; other site 478434008346 trimer interface [polypeptide binding]; other site 478434008347 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 478434008348 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 478434008349 Soluble P-type ATPase [General function prediction only]; Region: COG4087 478434008350 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 478434008351 Thermus thermophilus CsoR, a Cu(I)-sensing transcriptional regulator, and related domains; this domain family was previously known as part of DUF156; Region: TthCsoR-like_DUF156; cd10151 478434008352 putative homodimer interface [polypeptide binding]; other site 478434008353 putative homotetramer interface [polypeptide binding]; other site 478434008354 allosteric switch controlling residues; other site 478434008355 putative metal binding site [ion binding]; other site 478434008356 putative homodimer-homodimer interface [polypeptide binding]; other site 478434008357 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 478434008358 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 478434008359 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 478434008360 homotetrameric interface [polypeptide binding]; other site 478434008361 putative active site [active] 478434008362 metal binding site [ion binding]; metal-binding site 478434008363 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 478434008364 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 478434008365 metal ion-dependent adhesion site (MIDAS); other site 478434008366 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 478434008367 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 478434008368 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 478434008369 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 478434008370 purine monophosphate binding site [chemical binding]; other site 478434008371 dimer interface [polypeptide binding]; other site 478434008372 putative catalytic residues [active] 478434008373 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 478434008374 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 478434008375 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 478434008376 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 478434008377 active site 478434008378 substrate binding site [chemical binding]; other site 478434008379 cosubstrate binding site; other site 478434008380 catalytic site [active] 478434008381 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 478434008382 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 478434008383 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 478434008384 CoA binding domain; Region: CoA_binding; smart00881 478434008385 CoA-ligase; Region: Ligase_CoA; pfam00549 478434008386 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 478434008387 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 478434008388 CoA-ligase; Region: Ligase_CoA; pfam00549 478434008389 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 478434008390 Peptidase family M23; Region: Peptidase_M23; pfam01551 478434008391 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 478434008392 Part of AAA domain; Region: AAA_19; pfam13245 478434008393 Family description; Region: UvrD_C_2; pfam13538 478434008394 hypothetical protein; Provisional; Region: PRK07857 478434008395 Predicted esterase [General function prediction only]; Region: COG0627 478434008396 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 478434008397 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 478434008398 active site 478434008399 dimer interface [polypeptide binding]; other site 478434008400 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 478434008401 dimer interface [polypeptide binding]; other site 478434008402 active site 478434008403 short chain dehydrogenase; Provisional; Region: PRK08251 478434008404 classical (c) SDR, subgroup 6; Region: SDR_c6; cd05350 478434008405 putative NAD(P) binding site [chemical binding]; other site 478434008406 active site 478434008407 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 478434008408 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 478434008409 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 478434008410 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 478434008411 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 478434008412 anti sigma factor interaction site; other site 478434008413 regulatory phosphorylation site [posttranslational modification]; other site 478434008414 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 478434008415 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 478434008416 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 478434008417 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 478434008418 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 478434008419 ATP-dependent DNA ligase; Reviewed; Region: PRK09632 478434008420 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 478434008421 nucleotide binding site [chemical binding]; other site 478434008422 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 478434008423 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 478434008424 active site 478434008425 DNA binding site [nucleotide binding] 478434008426 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 478434008427 DNA binding site [nucleotide binding] 478434008428 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 478434008429 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 478434008430 putative DNA binding site [nucleotide binding]; other site 478434008431 putative homodimer interface [polypeptide binding]; other site 478434008432 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 478434008433 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 478434008434 dimer interface [polypeptide binding]; other site 478434008435 conserved gate region; other site 478434008436 putative PBP binding loops; other site 478434008437 ABC-ATPase subunit interface; other site 478434008438 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 478434008439 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 478434008440 dimer interface [polypeptide binding]; other site 478434008441 conserved gate region; other site 478434008442 putative PBP binding loops; other site 478434008443 ABC-ATPase subunit interface; other site 478434008444 phosphate ABC transporter, phosphate-binding protein; Region: 3a0107s03; TIGR00975 478434008445 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14271 478434008446 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 478434008447 Walker A/P-loop; other site 478434008448 ATP binding site [chemical binding]; other site 478434008449 Q-loop/lid; other site 478434008450 ABC transporter signature motif; other site 478434008451 Walker B; other site 478434008452 D-loop; other site 478434008453 H-loop/switch region; other site 478434008454 PBP superfamily domain; Region: PBP_like_2; cl17296 478434008455 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 478434008456 Catalytic domain of Protein Kinases; Region: PKc; cd00180 478434008457 active site 478434008458 ATP binding site [chemical binding]; other site 478434008459 substrate binding site [chemical binding]; other site 478434008460 activation loop (A-loop); other site 478434008461 Uncharacterized conserved protein [Function unknown]; Region: COG3391 478434008462 NHL repeat; Region: NHL; pfam01436 478434008463 NHL repeat; Region: NHL; pfam01436 478434008464 NHL repeat; Region: NHL; pfam01436 478434008465 NHL repeat; Region: NHL; pfam01436 478434008466 NHL repeat; Region: NHL; pfam01436 478434008467 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 478434008468 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 478434008469 dimer interface [polypeptide binding]; other site 478434008470 conserved gate region; other site 478434008471 putative PBP binding loops; other site 478434008472 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 478434008473 ABC-ATPase subunit interface; other site 478434008474 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 478434008475 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 478434008476 dimer interface [polypeptide binding]; other site 478434008477 conserved gate region; other site 478434008478 putative PBP binding loops; other site 478434008479 ABC-ATPase subunit interface; other site 478434008480 phosphate ABC transporter, phosphate-binding protein; Region: 3a0107s03; TIGR00975 478434008481 short chain dehydrogenase; Provisional; Region: PRK07814 478434008482 classical (c) SDRs; Region: SDR_c; cd05233 478434008483 NAD(P) binding site [chemical binding]; other site 478434008484 active site 478434008485 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 478434008486 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 478434008487 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 478434008488 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 478434008489 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 478434008490 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 478434008491 putative active site pocket [active] 478434008492 dimerization interface [polypeptide binding]; other site 478434008493 putative catalytic residue [active] 478434008494 Phage-related replication protein [General function prediction only]; Region: COG4195 478434008495 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 478434008496 Probable transposase; Region: OrfB_IS605; pfam01385 478434008497 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 478434008498 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 478434008499 catalytic residues [active] 478434008500 catalytic nucleophile [active] 478434008501 Transposase, Mutator family; Region: Transposase_mut; pfam00872 478434008502 MULE transposase domain; Region: MULE; pfam10551 478434008503 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 478434008504 Coenzyme A binding pocket [chemical binding]; other site 478434008505 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 478434008506 BCCT family transporter; Region: BCCT; pfam02028 478434008507 PE family; Region: PE; pfam00934 478434008508 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478434008509 PPE family; Region: PPE; pfam00823 478434008510 acetyl-CoA acetyltransferase; Provisional; Region: PRK06289 478434008511 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 478434008512 active site 478434008513 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 478434008514 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 478434008515 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 478434008516 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 478434008517 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 478434008518 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 478434008519 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 478434008520 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 478434008521 hydrophobic ligand binding site; other site 478434008522 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 478434008523 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 478434008524 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 478434008525 Soluble P-type ATPase [General function prediction only]; Region: COG4087 478434008526 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 478434008527 Beta-lactamase; Region: Beta-lactamase; pfam00144 478434008528 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 478434008529 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 478434008530 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 478434008531 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 478434008532 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 478434008533 substrate binding site [chemical binding]; other site 478434008534 oxyanion hole (OAH) forming residues; other site 478434008535 trimer interface [polypeptide binding]; other site 478434008536 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 478434008537 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; COG0825 478434008538 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 478434008539 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 478434008540 active site 478434008541 phosphorylation site [posttranslational modification] 478434008542 intermolecular recognition site; other site 478434008543 dimerization interface [polypeptide binding]; other site 478434008544 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 478434008545 DNA binding site [nucleotide binding] 478434008546 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 478434008547 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 478434008548 dimerization interface [polypeptide binding]; other site 478434008549 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 478434008550 dimer interface [polypeptide binding]; other site 478434008551 phosphorylation site [posttranslational modification] 478434008552 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 478434008553 Mg2+ binding site [ion binding]; other site 478434008554 G-X-G motif; other site 478434008555 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 478434008556 BON domain; Region: BON; pfam04972 478434008557 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 478434008558 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 478434008559 ligand binding site [chemical binding]; other site 478434008560 Protein of unknown function (DUF2630); Region: DUF2630; pfam10944 478434008561 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 478434008562 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 478434008563 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 478434008564 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 478434008565 dimer interface [polypeptide binding]; other site 478434008566 active site 478434008567 citrylCoA binding site [chemical binding]; other site 478434008568 NADH binding [chemical binding]; other site 478434008569 cationic pore residues; other site 478434008570 oxalacetate/citrate binding site [chemical binding]; other site 478434008571 coenzyme A binding site [chemical binding]; other site 478434008572 catalytic triad [active] 478434008573 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 478434008574 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 478434008575 AAA ATPase domain; Region: AAA_16; pfam13191 478434008576 Predicted ATPase [General function prediction only]; Region: COG3903 478434008577 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 478434008578 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 478434008579 potential frameshift: common BLAST hit: gi|224989286|ref|YP_002643973.1| monooxygenase 478434008580 IkappaB kinase complex, IKAP component [Transcription]; Region: COG5290 478434008581 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 478434008582 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 478434008583 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 478434008584 cyclase homology domain; Region: CHD; cd07302 478434008585 nucleotidyl binding site; other site 478434008586 metal binding site [ion binding]; metal-binding site 478434008587 dimer interface [polypeptide binding]; other site 478434008588 Predicted ATPase [General function prediction only]; Region: COG3903 478434008589 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 478434008590 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 478434008591 DNA binding residues [nucleotide binding] 478434008592 dimerization interface [polypeptide binding]; other site 478434008593 Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109 478434008594 dimer interface [polypeptide binding]; other site 478434008595 Citrate synthase; Region: Citrate_synt; pfam00285 478434008596 active site 478434008597 citrylCoA binding site [chemical binding]; other site 478434008598 oxalacetate/citrate binding site [chemical binding]; other site 478434008599 coenzyme A binding site [chemical binding]; other site 478434008600 catalytic triad [active] 478434008601 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 478434008602 putative catalytic site [active] 478434008603 putative phosphate binding site [ion binding]; other site 478434008604 putative metal binding site [ion binding]; other site 478434008605 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 478434008606 putative dimer interface [polypeptide binding]; other site 478434008607 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 478434008608 Ferredoxin [Energy production and conversion]; Region: COG1146 478434008609 4Fe-4S binding domain; Region: Fer4; pfam00037 478434008610 ferredoxin-NADP+ reductase; Region: PLN02852 478434008611 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 478434008612 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 478434008613 phosphoserine aminotransferase, putative; Region: serC_3; TIGR01366 478434008614 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 478434008615 catalytic residue [active] 478434008616 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 478434008617 Protein of unknown function (DUF2537); Region: DUF2537; pfam10801 478434008618 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 478434008619 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 478434008620 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 478434008621 MarR family; Region: MarR; pfam01047 478434008622 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 478434008623 Protein of unknown function (DUF2530); Region: DUF2530; pfam10745 478434008624 PPE family; Region: PPE; pfam00823 478434008625 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478434008626 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478434008627 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478434008628 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 478434008629 H+ Antiporter protein; Region: 2A0121; TIGR00900 478434008630 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 478434008631 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398 478434008632 FIST N domain; Region: FIST; pfam08495 478434008633 FIST C domain; Region: FIST_C; pfam10442 478434008634 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 478434008635 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 478434008636 active site 478434008637 PE family; Region: PE; pfam00934 478434008638 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 478434008639 DNA-binding site [nucleotide binding]; DNA binding site 478434008640 RNA-binding motif; other site 478434008641 hypothetical protein; Provisional; Region: PRK11770 478434008642 Domain of unknown function (DUF307); Region: DUF307; pfam03733 478434008643 Domain of unknown function (DUF307); Region: DUF307; pfam03733 478434008644 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 478434008645 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 478434008646 FeS/SAM binding site; other site 478434008647 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 478434008648 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 478434008649 MoaE interaction surface [polypeptide binding]; other site 478434008650 MoeB interaction surface [polypeptide binding]; other site 478434008651 thiocarboxylated glycine; other site 478434008652 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 478434008653 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 478434008654 MoaE homodimer interface [polypeptide binding]; other site 478434008655 MoaD interaction [polypeptide binding]; other site 478434008656 active site residues [active] 478434008657 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 478434008658 MPT binding site; other site 478434008659 trimer interface [polypeptide binding]; other site 478434008660 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 478434008661 trimer interface [polypeptide binding]; other site 478434008662 dimer interface [polypeptide binding]; other site 478434008663 putative active site [active] 478434008664 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 478434008665 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 478434008666 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 478434008667 ATP binding site [chemical binding]; other site 478434008668 putative Mg++ binding site [ion binding]; other site 478434008669 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 478434008670 nucleotide binding region [chemical binding]; other site 478434008671 ATP-binding site [chemical binding]; other site 478434008672 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 478434008673 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 478434008674 substrate binding site [chemical binding]; other site 478434008675 oxyanion hole (OAH) forming residues; other site 478434008676 trimer interface [polypeptide binding]; other site 478434008677 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 478434008678 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 478434008679 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 478434008680 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 478434008681 dimer interface [polypeptide binding]; other site 478434008682 active site 478434008683 aminotransferase; Validated; Region: PRK07777 478434008684 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 478434008685 pyridoxal 5'-phosphate binding site [chemical binding]; other site 478434008686 homodimer interface [polypeptide binding]; other site 478434008687 catalytic residue [active] 478434008688 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 478434008689 putative hydrophobic ligand binding site [chemical binding]; other site 478434008690 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 478434008691 putative hydrophobic ligand binding site [chemical binding]; other site 478434008692 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 478434008693 CoA-transferase family III; Region: CoA_transf_3; pfam02515 478434008694 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 478434008695 putative hydrophobic ligand binding site [chemical binding]; other site 478434008696 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 478434008697 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 478434008698 dimer interface [polypeptide binding]; other site 478434008699 PYR/PP interface [polypeptide binding]; other site 478434008700 TPP binding site [chemical binding]; other site 478434008701 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 478434008702 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 478434008703 TPP-binding site [chemical binding]; other site 478434008704 dimer interface [polypeptide binding]; other site 478434008705 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 478434008706 short chain dehydrogenase; Provisional; Region: PRK05876 478434008707 classical (c) SDRs; Region: SDR_c; cd05233 478434008708 NAD(P) binding site [chemical binding]; other site 478434008709 active site 478434008710 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 478434008711 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 478434008712 multidrug resistance protein MdtH; Provisional; Region: PRK11646 478434008713 putative substrate translocation pore; other site 478434008714 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 478434008715 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 478434008716 dimer interface [polypeptide binding]; other site 478434008717 pyridoxal 5'-phosphate binding site [chemical binding]; other site 478434008718 catalytic residue [active] 478434008719 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 478434008720 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 478434008721 Multicopper oxidase; Region: Cu-oxidase; pfam00394 478434008722 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 478434008723 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 478434008724 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 478434008725 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 478434008726 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 478434008727 active site 478434008728 phosphorylation site [posttranslational modification] 478434008729 intermolecular recognition site; other site 478434008730 dimerization interface [polypeptide binding]; other site 478434008731 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 478434008732 DNA binding residues [nucleotide binding] 478434008733 dimerization interface [polypeptide binding]; other site 478434008734 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 478434008735 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 478434008736 tetramer interface [polypeptide binding]; other site 478434008737 TPP-binding site [chemical binding]; other site 478434008738 heterodimer interface [polypeptide binding]; other site 478434008739 phosphorylation loop region [posttranslational modification] 478434008740 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 478434008741 putative substrate translocation pore; other site 478434008742 Major Facilitator Superfamily; Region: MFS_1; pfam07690 478434008743 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 478434008744 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478434008745 S-adenosylmethionine binding site [chemical binding]; other site 478434008746 D-ala-D-ala dipeptidase; Region: Peptidase_M15; pfam01427 478434008747 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4861 478434008748 Uncharacterized protein conserved in bacteria (DUF2186); Region: DUF2186; pfam09952 478434008749 Predicted nucleotidyltransferase [General function prediction only]; Region: COG4849 478434008750 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 478434008751 Transposase; Region: HTH_Tnp_1; cl17663 478434008752 putative transposase OrfB; Reviewed; Region: PHA02517 478434008753 HTH-like domain; Region: HTH_21; pfam13276 478434008754 Integrase core domain; Region: rve; pfam00665 478434008755 Integrase core domain; Region: rve_3; pfam13683 478434008756 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 478434008757 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 478434008758 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 478434008759 nucleoside/Zn binding site; other site 478434008760 dimer interface [polypeptide binding]; other site 478434008761 catalytic motif [active] 478434008762 Transposase, Mutator family; Region: Transposase_mut; pfam00872 478434008763 MULE transposase domain; Region: MULE; pfam10551 478434008764 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 478434008765 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 478434008766 ATP binding site [chemical binding]; other site 478434008767 substrate interface [chemical binding]; other site 478434008768 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 478434008769 active site residue [active] 478434008770 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 478434008771 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 478434008772 active site residue [active] 478434008773 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 478434008774 active site residue [active] 478434008775 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 478434008776 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 478434008777 MoaE homodimer interface [polypeptide binding]; other site 478434008778 MoaD interaction [polypeptide binding]; other site 478434008779 active site residues [active] 478434008780 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478434008781 S-adenosylmethionine binding site [chemical binding]; other site 478434008782 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 478434008783 Cytochrome P450; Region: p450; cl12078 478434008784 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 478434008785 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 478434008786 DNA binding site [nucleotide binding] 478434008787 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478434008788 PPE family; Region: PPE; pfam00823 478434008789 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 478434008790 Integrase core domain; Region: rve; cl01316 478434008791 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 478434008792 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 478434008793 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 478434008794 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 478434008795 dimer interface [polypeptide binding]; other site 478434008796 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 478434008797 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 478434008798 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 478434008799 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 478434008800 Histidine kinase; Region: HisKA_3; pfam07730 478434008801 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 478434008802 ATP binding site [chemical binding]; other site 478434008803 Mg2+ binding site [ion binding]; other site 478434008804 G-X-G motif; other site 478434008805 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 478434008806 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 478434008807 active site 478434008808 phosphorylation site [posttranslational modification] 478434008809 intermolecular recognition site; other site 478434008810 dimerization interface [polypeptide binding]; other site 478434008811 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 478434008812 DNA binding residues [nucleotide binding] 478434008813 dimerization interface [polypeptide binding]; other site 478434008814 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 478434008815 Ligand Binding Site [chemical binding]; other site 478434008816 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478434008817 PPE family; Region: PPE; pfam00823 478434008818 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478434008819 PPE family; Region: PPE; pfam00823 478434008820 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 478434008821 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 478434008822 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 478434008823 active site 478434008824 AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337 478434008825 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 478434008826 FeS/SAM binding site; other site 478434008827 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 478434008828 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 478434008829 active site 478434008830 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 478434008831 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 478434008832 active site 478434008833 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 478434008834 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 478434008835 NAD(P) binding site [chemical binding]; other site 478434008836 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 478434008837 active site 478434008838 phosphorylation site [posttranslational modification] 478434008839 intermolecular recognition site; other site 478434008840 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478434008841 PPE family; Region: PPE; pfam00823 478434008842 NADH dehydrogenase subunit A; Validated; Region: PRK07928 478434008843 NADH dehydrogenase subunit B; Validated; Region: PRK06411 478434008844 NADH dehydrogenase subunit C; Provisional; Region: PRK07785 478434008845 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 478434008846 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 478434008847 NADH dehydrogenase subunit D; Validated; Region: PRK06075 478434008848 NADH dehydrogenase subunit E; Validated; Region: PRK07539 478434008849 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 478434008850 putative dimer interface [polypeptide binding]; other site 478434008851 [2Fe-2S] cluster binding site [ion binding]; other site 478434008852 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 478434008853 SLBB domain; Region: SLBB; pfam10531 478434008854 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 478434008855 NADH dehydrogenase subunit G; Validated; Region: PRK07860 478434008856 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 478434008857 catalytic loop [active] 478434008858 iron binding site [ion binding]; other site 478434008859 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 478434008860 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 478434008861 [4Fe-4S] binding site [ion binding]; other site 478434008862 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 478434008863 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 478434008864 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 478434008865 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 478434008866 4Fe-4S binding domain; Region: Fer4; pfam00037 478434008867 4Fe-4S binding domain; Region: Fer4; pfam00037 478434008868 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 478434008869 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 478434008870 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 478434008871 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 478434008872 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 478434008873 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 478434008874 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 478434008875 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 478434008876 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 478434008877 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478434008878 PPE family; Region: PPE; pfam00823 478434008879 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478434008880 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 478434008881 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478434008882 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 478434008883 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 478434008884 [2Fe-2S] cluster binding site [ion binding]; other site 478434008885 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_1; cd08885 478434008886 putative alpha subunit interface [polypeptide binding]; other site 478434008887 putative active site [active] 478434008888 putative substrate binding site [chemical binding]; other site 478434008889 Fe binding site [ion binding]; other site 478434008890 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 478434008891 Protein of unknown function DUF58; Region: DUF58; pfam01882 478434008892 MoxR-like ATPases [General function prediction only]; Region: COG0714 478434008893 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 478434008894 Walker A motif; other site 478434008895 ATP binding site [chemical binding]; other site 478434008896 Walker B motif; other site 478434008897 arginine finger; other site 478434008898 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 478434008899 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 478434008900 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478434008901 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 478434008902 putative active site [active] 478434008903 putative substrate binding site [chemical binding]; other site 478434008904 ATP binding site [chemical binding]; other site 478434008905 Phosphotransferase enzyme family; Region: APH; pfam01636 478434008906 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 478434008907 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 478434008908 hydroxyglutarate oxidase; Provisional; Region: PRK11728 478434008909 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 478434008910 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 478434008911 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 478434008912 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478434008913 short chain dehydrogenase; Validated; Region: PRK08264 478434008914 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 478434008915 NAD(P) binding site [chemical binding]; other site 478434008916 active site 478434008917 amidase; Provisional; Region: PRK06170 478434008918 Amidase; Region: Amidase; pfam01425 478434008919 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 478434008920 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 478434008921 TAP-like protein; Region: Abhydrolase_4; pfam08386 478434008922 Domain of unknown function (DUF385); Region: DUF385; pfam04075 478434008923 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 478434008924 AAA domain; Region: AAA_14; pfam13173 478434008925 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 478434008926 putative active site [active] 478434008927 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 478434008928 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4683 478434008929 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 478434008930 non-specific DNA binding site [nucleotide binding]; other site 478434008931 salt bridge; other site 478434008932 sequence-specific DNA binding site [nucleotide binding]; other site 478434008933 RES domain; Region: RES; pfam08808 478434008934 Winged helix-turn helix; Region: HTH_29; pfam13551 478434008935 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 478434008936 Helix-turn-helix domain; Region: HTH_38; pfam13936 478434008937 Integrase core domain; Region: rve; pfam00665 478434008938 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 478434008939 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 478434008940 hypothetical protein; Validated; Region: PRK00068 478434008941 Uncharacterized conserved protein [Function unknown]; Region: COG1615 478434008942 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 478434008943 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 478434008944 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 478434008945 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 478434008946 Uncharacterized conserved protein [Function unknown]; Region: COG5282 478434008947 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 478434008948 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 478434008949 ABC1 family; Region: ABC1; pfam03109 478434008950 Phosphotransferase enzyme family; Region: APH; pfam01636 478434008951 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 478434008952 active site 478434008953 ATP binding site [chemical binding]; other site 478434008954 Transcription factor WhiB; Region: Whib; pfam02467 478434008955 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 478434008956 Part of AAA domain; Region: AAA_19; pfam13245 478434008957 Family description; Region: UvrD_C_2; pfam13538 478434008958 HRDC domain; Region: HRDC; pfam00570 478434008959 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 478434008960 catalytic residues [active] 478434008961 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 478434008962 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 478434008963 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 478434008964 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 478434008965 putative NADH binding site [chemical binding]; other site 478434008966 putative active site [active] 478434008967 nudix motif; other site 478434008968 putative metal binding site [ion binding]; other site 478434008969 Ion channel; Region: Ion_trans_2; pfam07885 478434008970 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 478434008971 TrkA-N domain; Region: TrkA_N; pfam02254 478434008972 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 478434008973 Part of AAA domain; Region: AAA_19; pfam13245 478434008974 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 478434008975 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 478434008976 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 478434008977 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 478434008978 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 478434008979 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 478434008980 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 478434008981 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 478434008982 active site 478434008983 DNA binding site [nucleotide binding] 478434008984 TIGR02569 family protein; Region: TIGR02569_actnb 478434008985 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 478434008986 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 478434008987 ATP binding site [chemical binding]; other site 478434008988 substrate interface [chemical binding]; other site 478434008989 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 478434008990 active site residue [active] 478434008991 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 478434008992 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 478434008993 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478434008994 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 478434008995 tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like; Region: MiaE_2; pfam13794 478434008996 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 478434008997 DEAD-like helicases superfamily; Region: DEXDc; smart00487 478434008998 ATP binding site [chemical binding]; other site 478434008999 Mg++ binding site [ion binding]; other site 478434009000 motif III; other site 478434009001 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 478434009002 nucleotide binding region [chemical binding]; other site 478434009003 ATP-binding site [chemical binding]; other site 478434009004 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 478434009005 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 478434009006 P-loop; other site 478434009007 Magnesium ion binding site [ion binding]; other site 478434009008 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 478434009009 Magnesium ion binding site [ion binding]; other site 478434009010 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 478434009011 catalytic core [active] 478434009012 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 478434009013 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 478434009014 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 478434009015 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 478434009016 Transcription factor WhiB; Region: Whib; pfam02467 478434009017 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 478434009018 PAS domain S-box; Region: sensory_box; TIGR00229 478434009019 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 478434009020 Histidine kinase; Region: HisKA_2; pfam07568 478434009021 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 478434009022 ATP binding site [chemical binding]; other site 478434009023 Mg2+ binding site [ion binding]; other site 478434009024 G-X-G motif; other site 478434009025 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 478434009026 carboxyltransferase (CT) interaction site; other site 478434009027 biotinylation site [posttranslational modification]; other site 478434009028 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; TIGR03988 478434009029 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 478434009030 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 478434009031 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 478434009032 DNA binding residues [nucleotide binding] 478434009033 short chain dehydrogenase; Provisional; Region: PRK08278 478434009034 human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762 478434009035 NAD(P) binding site [chemical binding]; other site 478434009036 homodimer interface [polypeptide binding]; other site 478434009037 active site 478434009038 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 478434009039 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 478434009040 putative deacylase active site [active] 478434009041 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 478434009042 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 478434009043 Coenzyme A binding pocket [chemical binding]; other site 478434009044 Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases; Region: APH_ChoK_like_1; cd05155 478434009045 Phosphotransferase enzyme family; Region: APH; pfam01636 478434009046 putative active site [active] 478434009047 putative substrate binding site [chemical binding]; other site 478434009048 ATP binding site [chemical binding]; other site 478434009049 Uncharacterized conserved protein [Function unknown]; Region: COG2135 478434009050 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 478434009051 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 478434009052 hinge; other site 478434009053 active site 478434009054 Predicted GTPases [General function prediction only]; Region: COG1162 478434009055 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 478434009056 GTPase/Zn-binding domain interface [polypeptide binding]; other site 478434009057 GTP/Mg2+ binding site [chemical binding]; other site 478434009058 G4 box; other site 478434009059 G5 box; other site 478434009060 G1 box; other site 478434009061 Switch I region; other site 478434009062 G2 box; other site 478434009063 G3 box; other site 478434009064 Switch II region; other site 478434009065 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 478434009066 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 478434009067 putative di-iron ligands [ion binding]; other site 478434009068 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 478434009069 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 478434009070 FAD binding pocket [chemical binding]; other site 478434009071 FAD binding motif [chemical binding]; other site 478434009072 phosphate binding motif [ion binding]; other site 478434009073 beta-alpha-beta structure motif; other site 478434009074 NAD binding pocket [chemical binding]; other site 478434009075 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 478434009076 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 478434009077 catalytic loop [active] 478434009078 iron binding site [ion binding]; other site 478434009079 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 478434009080 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 478434009081 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 478434009082 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 478434009083 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 478434009084 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 478434009085 TrkA-C domain; Region: TrkA_C; pfam02080 478434009086 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 478434009087 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 478434009088 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 478434009089 putative substrate translocation pore; other site 478434009090 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 478434009091 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 478434009092 ligand binding site [chemical binding]; other site 478434009093 flexible hinge region; other site 478434009094 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 478434009095 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 478434009096 nucleophile elbow; other site 478434009097 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 478434009098 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 478434009099 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 478434009100 30S subunit binding site; other site 478434009101 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 478434009102 active site 478434009103 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 478434009104 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 478434009105 lipoprotein LpqB; Provisional; Region: PRK13616 478434009106 Sporulation and spore germination; Region: Germane; pfam10646 478434009107 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 478434009108 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 478434009109 dimerization interface [polypeptide binding]; other site 478434009110 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 478434009111 dimer interface [polypeptide binding]; other site 478434009112 phosphorylation site [posttranslational modification] 478434009113 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 478434009114 ATP binding site [chemical binding]; other site 478434009115 Mg2+ binding site [ion binding]; other site 478434009116 G-X-G motif; other site 478434009117 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 478434009118 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 478434009119 active site 478434009120 phosphorylation site [posttranslational modification] 478434009121 intermolecular recognition site; other site 478434009122 dimerization interface [polypeptide binding]; other site 478434009123 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 478434009124 DNA binding site [nucleotide binding] 478434009125 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 478434009126 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 478434009127 TMP-binding site; other site 478434009128 ATP-binding site [chemical binding]; other site 478434009129 Adenosylhomocysteinase; Provisional; Region: PTZ00075 478434009130 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 478434009131 homotetramer interface [polypeptide binding]; other site 478434009132 ligand binding site [chemical binding]; other site 478434009133 catalytic site [active] 478434009134 NAD binding site [chemical binding]; other site 478434009135 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478434009136 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 478434009137 Rubredoxin [Energy production and conversion]; Region: COG1773 478434009138 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 478434009139 iron binding site [ion binding]; other site 478434009140 Rubredoxin [Energy production and conversion]; Region: COG1773 478434009141 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 478434009142 iron binding site [ion binding]; other site 478434009143 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 478434009144 Fatty acid desaturase; Region: FA_desaturase; pfam00487 478434009145 Di-iron ligands [ion binding]; other site 478434009146 amino acid transporter; Region: 2A0306; TIGR00909 478434009147 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 478434009148 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 478434009149 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 478434009150 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 478434009151 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 478434009152 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 478434009153 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 478434009154 active site 478434009155 substrate binding site [chemical binding]; other site 478434009156 metal binding site [ion binding]; metal-binding site 478434009157 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 478434009158 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 478434009159 Transcription factor WhiB; Region: Whib; pfam02467 478434009160 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 478434009161 LPPG:FO 2-phospho-L-lactate transferase; important in F420 biosynthesis; Region: CofD_like; cd07186 478434009162 phosphate binding site [ion binding]; other site 478434009163 dimer interface [polypeptide binding]; other site 478434009164 substrate binding site [chemical binding]; other site 478434009165 F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294 478434009166 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 478434009167 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 478434009168 putative FMN binding site [chemical binding]; other site 478434009169 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 478434009170 Methyltransferase domain; Region: Methyltransf_26; pfam13659 478434009171 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 478434009172 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 478434009173 active site 478434009174 Substrate binding site; other site 478434009175 Mg++ binding site; other site 478434009176 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 478434009177 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 478434009178 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 478434009179 Probable Catalytic site; other site 478434009180 metal-binding site 478434009181 dTDP-4-dehydrorhamnose reductase; Region: rmlD; TIGR01214 478434009182 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 478434009183 NADP binding site [chemical binding]; other site 478434009184 active site 478434009185 putative substrate binding site [chemical binding]; other site 478434009186 Transcriptional regulator [Transcription]; Region: LytR; COG1316 478434009187 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 478434009188 TIGR03089 family protein; Region: TIGR03089 478434009189 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 478434009190 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 478434009191 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 478434009192 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 478434009193 active site 478434009194 motif I; other site 478434009195 motif II; other site 478434009196 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 478434009197 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 478434009198 CoA-transferase family III; Region: CoA_transf_3; pfam02515 478434009199 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 478434009200 Sulfate transporter family; Region: Sulfate_transp; pfam00916 478434009201 Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: CynT; COG0288 478434009202 active site clefts [active] 478434009203 zinc binding site [ion binding]; other site 478434009204 dimer interface [polypeptide binding]; other site 478434009205 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 478434009206 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 478434009207 FAD binding site [chemical binding]; other site 478434009208 homotetramer interface [polypeptide binding]; other site 478434009209 substrate binding pocket [chemical binding]; other site 478434009210 catalytic base [active] 478434009211 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 478434009212 Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase) [Nucleotide transport and metabolism]; Region: PurK; COG0026 478434009213 ATP-grasp domain; Region: ATP-grasp; pfam02222 478434009214 Predicted membrane protein [Function unknown]; Region: COG2246 478434009215 GtrA-like protein; Region: GtrA; pfam04138 478434009216 Bacterial PH domain; Region: DUF304; pfam03703 478434009217 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 478434009218 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 478434009219 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 478434009220 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 478434009221 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 478434009222 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 478434009223 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 478434009224 Maf-like protein; Region: Maf; pfam02545 478434009225 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 478434009226 active site 478434009227 dimer interface [polypeptide binding]; other site 478434009228 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 478434009229 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 478434009230 active site residue [active] 478434009231 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 478434009232 active site residue [active] 478434009233 Fe-S metabolism associated domain; Region: SufE; pfam02657 478434009234 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 478434009235 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 478434009236 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 478434009237 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 478434009238 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 478434009239 carboxyltransferase (CT) interaction site; other site 478434009240 biotinylation site [posttranslational modification]; other site 478434009241 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122 478434009242 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 478434009243 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 478434009244 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 478434009245 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 478434009246 L-lysine aminotransferase; Provisional; Region: PRK08297 478434009247 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 478434009248 inhibitor-cofactor binding pocket; inhibition site 478434009249 pyridoxal 5'-phosphate binding site [chemical binding]; other site 478434009250 catalytic residue [active] 478434009251 putative DNA binding site [nucleotide binding]; other site 478434009252 dimerization interface [polypeptide binding]; other site 478434009253 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 478434009254 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 478434009255 putative Zn2+ binding site [ion binding]; other site 478434009256 AsnC family; Region: AsnC_trans_reg; pfam01037 478434009257 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 478434009258 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 478434009259 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 478434009260 tetrameric interface [polypeptide binding]; other site 478434009261 NAD binding site [chemical binding]; other site 478434009262 catalytic residues [active] 478434009263 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 478434009264 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 478434009265 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478434009266 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 478434009267 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 478434009268 ATP binding site [chemical binding]; other site 478434009269 putative Mg++ binding site [ion binding]; other site 478434009270 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 478434009271 nucleotide binding region [chemical binding]; other site 478434009272 ATP-binding site [chemical binding]; other site 478434009273 DEAD/H associated; Region: DEAD_assoc; pfam08494 478434009274 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 478434009275 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 478434009276 putative DNA binding site [nucleotide binding]; other site 478434009277 catalytic residue [active] 478434009278 putative H2TH interface [polypeptide binding]; other site 478434009279 putative catalytic residues [active] 478434009280 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 478434009281 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 478434009282 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 478434009283 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 478434009284 Sulfatase; Region: Sulfatase; pfam00884 478434009285 Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558 478434009286 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 478434009287 probable active site [active] 478434009288 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 478434009289 PhoU domain; Region: PhoU; pfam01895 478434009290 PhoU domain; Region: PhoU; pfam01895 478434009291 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 478434009292 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 478434009293 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 478434009294 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 478434009295 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 478434009296 putative active site pocket [active] 478434009297 dimerization interface [polypeptide binding]; other site 478434009298 putative catalytic residue [active] 478434009299 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 478434009300 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 478434009301 metal binding site [ion binding]; metal-binding site 478434009302 putative dimer interface [polypeptide binding]; other site 478434009303 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 478434009304 amidohydrolase; Region: amidohydrolases; TIGR01891 478434009305 metal binding site [ion binding]; metal-binding site 478434009306 purine nucleoside phosphorylase; Provisional; Region: PRK08202 478434009307 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 478434009308 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 478434009309 active site 478434009310 substrate binding site [chemical binding]; other site 478434009311 metal binding site [ion binding]; metal-binding site 478434009312 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 478434009313 active site 478434009314 Phosphoesterase family; Region: Phosphoesterase; pfam04185 478434009315 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 478434009316 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 478434009317 adenosine deaminase; Provisional; Region: PRK09358 478434009318 active site 478434009319 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 478434009320 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 478434009321 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 478434009322 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 478434009323 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 478434009324 active site 478434009325 catalytic motif [active] 478434009326 Zn binding site [ion binding]; other site 478434009327 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 478434009328 putative Iron-sulfur protein interface [polypeptide binding]; other site 478434009329 putative proximal heme binding site [chemical binding]; other site 478434009330 putative SdhD-like interface [polypeptide binding]; other site 478434009331 putative distal heme binding site [chemical binding]; other site 478434009332 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 478434009333 putative Iron-sulfur protein interface [polypeptide binding]; other site 478434009334 putative proximal heme binding site [chemical binding]; other site 478434009335 putative SdhC-like subunit interface [polypeptide binding]; other site 478434009336 putative distal heme binding site [chemical binding]; other site 478434009337 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 478434009338 L-aspartate oxidase; Provisional; Region: PRK06175 478434009339 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 478434009340 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 478434009341 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 478434009342 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 478434009343 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 478434009344 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478434009345 S-adenosylmethionine binding site [chemical binding]; other site 478434009346 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 478434009347 MoaE interaction surface [polypeptide binding]; other site 478434009348 MoeB interaction surface [polypeptide binding]; other site 478434009349 thiocarboxylated glycine; other site 478434009350 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 478434009351 MoaE homodimer interface [polypeptide binding]; other site 478434009352 MoaD interaction [polypeptide binding]; other site 478434009353 active site residues [active] 478434009354 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 478434009355 trimer interface [polypeptide binding]; other site 478434009356 dimer interface [polypeptide binding]; other site 478434009357 putative active site [active] 478434009358 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 478434009359 aromatic arch; other site 478434009360 DCoH dimer interaction site [polypeptide binding]; other site 478434009361 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 478434009362 DCoH tetramer interaction site [polypeptide binding]; other site 478434009363 substrate binding site [chemical binding]; other site 478434009364 putative transposase OrfB; Reviewed; Region: PHA02517 478434009365 HTH-like domain; Region: HTH_21; pfam13276 478434009366 Integrase core domain; Region: rve; pfam00665 478434009367 Integrase core domain; Region: rve_3; pfam13683 478434009368 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 478434009369 Transposase; Region: HTH_Tnp_1; cl17663 478434009370 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 478434009371 hypothetical protein; Provisional; Region: PRK06541 478434009372 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 478434009373 inhibitor-cofactor binding pocket; inhibition site 478434009374 pyridoxal 5'-phosphate binding site [chemical binding]; other site 478434009375 catalytic residue [active] 478434009376 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 478434009377 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 478434009378 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 478434009379 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 478434009380 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 478434009381 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 478434009382 active site 478434009383 dimer interface [polypeptide binding]; other site 478434009384 Protein of unknown function (DUF732); Region: DUF732; pfam05305 478434009385 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 478434009386 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 478434009387 DNA binding residues [nucleotide binding] 478434009388 dimer interface [polypeptide binding]; other site 478434009389 metal binding site [ion binding]; metal-binding site 478434009390 inner membrane protein YhjD; Region: TIGR00766 478434009391 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 478434009392 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 478434009393 active site 478434009394 HIGH motif; other site 478434009395 dimer interface [polypeptide binding]; other site 478434009396 KMSKS motif; other site 478434009397 acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875 478434009398 isocitrate dehydrogenase; Validated; Region: PRK08299 478434009399 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 478434009400 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 478434009401 homodimer interface [polypeptide binding]; other site 478434009402 substrate-cofactor binding pocket; other site 478434009403 pyridoxal 5'-phosphate binding site [chemical binding]; other site 478434009404 catalytic residue [active] 478434009405 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 478434009406 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 478434009407 Methyltransferase domain; Region: Methyltransf_23; pfam13489 478434009408 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478434009409 S-adenosylmethionine binding site [chemical binding]; other site 478434009410 PPE family; Region: PPE; pfam00823 478434009411 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478434009412 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478434009413 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478434009414 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478434009415 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478434009416 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478434009417 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478434009418 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478434009419 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478434009420 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478434009421 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478434009422 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478434009423 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478434009424 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478434009425 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478434009426 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478434009427 PE family; Region: PE; pfam00934 478434009428 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 478434009429 PPE family; Region: PPE; pfam00823 478434009430 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478434009431 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478434009432 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478434009433 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478434009434 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478434009435 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478434009436 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478434009437 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478434009438 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478434009439 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478434009440 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478434009441 Transposase; Region: DEDD_Tnp_IS110; pfam01548 478434009442 Transposase; Region: DDE_Tnp_ISL3; pfam01610 478434009443 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478434009444 PPE family; Region: PPE; pfam00823 478434009445 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478434009446 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478434009447 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478434009448 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478434009449 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478434009450 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478434009451 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478434009452 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478434009453 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478434009454 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478434009455 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478434009456 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478434009457 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478434009458 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478434009459 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478434009460 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478434009461 Berberine and berberine like; Region: BBE; pfam08031 478434009462 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 478434009463 Protein of unknown function (DUF732); Region: DUF732; pfam05305 478434009464 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 478434009465 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 478434009466 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 478434009467 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 478434009468 homodimer interface [polypeptide binding]; other site 478434009469 NADP binding site [chemical binding]; other site 478434009470 substrate binding site [chemical binding]; other site 478434009471 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 478434009472 Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769 478434009473 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 478434009474 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 478434009475 active site 478434009476 FMN binding site [chemical binding]; other site 478434009477 substrate binding site [chemical binding]; other site 478434009478 putative catalytic residue [active] 478434009479 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 478434009480 phosphate binding site [ion binding]; other site 478434009481 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 478434009482 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 478434009483 phosphopeptide binding site; other site 478434009484 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 478434009485 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 478434009486 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 478434009487 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 478434009488 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 478434009489 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 478434009490 G1 box; other site 478434009491 GTP/Mg2+ binding site [chemical binding]; other site 478434009492 G2 box; other site 478434009493 Switch I region; other site 478434009494 G3 box; other site 478434009495 Switch II region; other site 478434009496 G4 box; other site 478434009497 G5 box; other site 478434009498 Protein of unknown function (DUF742); Region: DUF742; pfam05331 478434009499 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 478434009500 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 478434009501 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 478434009502 ATP binding site [chemical binding]; other site 478434009503 Mg2+ binding site [ion binding]; other site 478434009504 G-X-G motif; other site 478434009505 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 478434009506 PE family; Region: PE; pfam00934 478434009507 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 478434009508 FMN binding site [chemical binding]; other site 478434009509 dimer interface [polypeptide binding]; other site 478434009510 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 478434009511 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 478434009512 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 478434009513 active site 478434009514 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 478434009515 generic binding surface II; other site 478434009516 generic binding surface I; other site 478434009517 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 478434009518 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 478434009519 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 478434009520 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 478434009521 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 478434009522 active site 478434009523 motif I; other site 478434009524 motif II; other site 478434009525 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 478434009526 substrate binding site [chemical binding]; other site 478434009527 oxyanion hole (OAH) forming residues; other site 478434009528 trimer interface [polypeptide binding]; other site 478434009529 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 478434009530 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 478434009531 Amidase; Region: Amidase; pfam01425 478434009532 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 478434009533 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 478434009534 motif II; other site 478434009535 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 478434009536 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 478434009537 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 478434009538 TPP-binding site [chemical binding]; other site 478434009539 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 478434009540 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 478434009541 PYR/PP interface [polypeptide binding]; other site 478434009542 dimer interface [polypeptide binding]; other site 478434009543 TPP binding site [chemical binding]; other site 478434009544 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 478434009545 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 478434009546 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 478434009547 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 478434009548 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 478434009549 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 478434009550 substrate binding pocket [chemical binding]; other site 478434009551 chain length determination region; other site 478434009552 substrate-Mg2+ binding site; other site 478434009553 catalytic residues [active] 478434009554 aspartate-rich region 1; other site 478434009555 active site lid residues [active] 478434009556 aspartate-rich region 2; other site 478434009557 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 478434009558 putative active site [active] 478434009559 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 478434009560 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 478434009561 Transposase domain (DUF772); Region: DUF772; pfam05598 478434009562 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 478434009563 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 478434009564 PE family; Region: PE; pfam00934 478434009565 enoyl-CoA hydratase; Region: PLN02864 478434009566 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 478434009567 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 478434009568 dimer interaction site [polypeptide binding]; other site 478434009569 substrate-binding tunnel; other site 478434009570 active site 478434009571 catalytic site [active] 478434009572 substrate binding site [chemical binding]; other site 478434009573 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 478434009574 short chain dehydrogenase; Provisional; Region: PRK07201 478434009575 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 478434009576 putative NAD(P) binding site [chemical binding]; other site 478434009577 active site 478434009578 putative substrate binding site [chemical binding]; other site 478434009579 classical (c) SDRs; Region: SDR_c; cd05233 478434009580 NAD(P) binding site [chemical binding]; other site 478434009581 active site 478434009582 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 478434009583 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478434009584 S-adenosylmethionine binding site [chemical binding]; other site 478434009585 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 478434009586 active site 478434009587 DNA Polymerase Y-family; Region: PolY_like; cd03468 478434009588 DNA binding site [nucleotide binding] 478434009589 GMP synthase; Reviewed; Region: guaA; PRK00074 478434009590 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 478434009591 AMP/PPi binding site [chemical binding]; other site 478434009592 candidate oxyanion hole; other site 478434009593 catalytic triad [active] 478434009594 potential glutamine specificity residues [chemical binding]; other site 478434009595 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 478434009596 ATP Binding subdomain [chemical binding]; other site 478434009597 Ligand Binding sites [chemical binding]; other site 478434009598 Dimerization subdomain; other site 478434009599 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 478434009600 active site lid residues [active] 478434009601 substrate binding pocket [chemical binding]; other site 478434009602 catalytic residues [active] 478434009603 substrate-Mg2+ binding site; other site 478434009604 aspartate-rich region 1; other site 478434009605 aspartate-rich region 2; other site 478434009606 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 478434009607 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 478434009608 substrate binding pocket [chemical binding]; other site 478434009609 chain length determination region; other site 478434009610 substrate-Mg2+ binding site; other site 478434009611 catalytic residues [active] 478434009612 aspartate-rich region 1; other site 478434009613 active site lid residues [active] 478434009614 aspartate-rich region 2; other site 478434009615 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 478434009616 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 478434009617 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 478434009618 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 478434009619 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 478434009620 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 478434009621 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 478434009622 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 478434009623 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 478434009624 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 478434009625 inhibitor-cofactor binding pocket; inhibition site 478434009626 pyridoxal 5'-phosphate binding site [chemical binding]; other site 478434009627 catalytic residue [active] 478434009628 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 478434009629 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 478434009630 hypothetical protein; Provisional; Region: PRK07579 478434009631 Formyltransferase, catalytic core domain; Region: FMT_core; cd08369 478434009632 active site 478434009633 cosubstrate binding site; other site 478434009634 substrate binding site [chemical binding]; other site 478434009635 catalytic site [active] 478434009636 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 478434009637 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478434009638 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 478434009639 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 478434009640 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 478434009641 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 478434009642 putative active site [active] 478434009643 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 478434009644 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 478434009645 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 478434009646 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 478434009647 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 478434009648 phosphate binding site [ion binding]; other site 478434009649 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 478434009650 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 478434009651 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 478434009652 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 478434009653 active site 478434009654 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 478434009655 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 478434009656 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 478434009657 DNA binding residues [nucleotide binding] 478434009658 Transcription factor WhiB; Region: Whib; pfam02467 478434009659 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 478434009660 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 478434009661 ring oligomerisation interface [polypeptide binding]; other site 478434009662 ATP/Mg binding site [chemical binding]; other site 478434009663 stacking interactions; other site 478434009664 hinge regions; other site 478434009665 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 478434009666 oligomerisation interface [polypeptide binding]; other site 478434009667 mobile loop; other site 478434009668 roof hairpin; other site 478434009669 UGMP family protein; Validated; Region: PRK09604 478434009670 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 478434009671 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 478434009672 Coenzyme A binding pocket [chemical binding]; other site 478434009673 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 478434009674 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; pfam02367 478434009675 alanine racemase; Reviewed; Region: alr; PRK00053 478434009676 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 478434009677 active site 478434009678 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 478434009679 dimer interface [polypeptide binding]; other site 478434009680 substrate binding site [chemical binding]; other site 478434009681 catalytic residues [active] 478434009682 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478434009683 PPE family; Region: PPE; pfam00823 478434009684 Integrase core domain; Region: rve; pfam00665 478434009685 Integrase core domain; Region: rve_3; pfam13683 478434009686 Transposase, Mutator family; Region: Transposase_mut; pfam00872 478434009687 MULE transposase domain; Region: MULE; pfam10551 478434009688 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 478434009689 pyridoxal 5'-phosphate binding site [chemical binding]; other site 478434009690 catalytic residue [active] 478434009691 Uncharacterized conserved protein [Function unknown]; Region: COG0062 478434009692 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 478434009693 putative substrate binding site [chemical binding]; other site 478434009694 putative ATP binding site [chemical binding]; other site 478434009695 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 478434009696 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 478434009697 glutaminase active site [active] 478434009698 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 478434009699 dimer interface [polypeptide binding]; other site 478434009700 active site 478434009701 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 478434009702 dimer interface [polypeptide binding]; other site 478434009703 active site 478434009704 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 478434009705 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 478434009706 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 478434009707 active site 478434009708 substrate binding site [chemical binding]; other site 478434009709 metal binding site [ion binding]; metal-binding site 478434009710 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 478434009711 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 478434009712 23S rRNA interface [nucleotide binding]; other site 478434009713 L3 interface [polypeptide binding]; other site 478434009714 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 478434009715 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 478434009716 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 478434009717 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 478434009718 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 478434009719 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 478434009720 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 478434009721 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 478434009722 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 478434009723 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 478434009724 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 478434009725 active site 478434009726 catalytic residues [active] 478434009727 Protein of unknown function (DUF690); Region: DUF690; cl04939 478434009728 Cutinase; Region: Cutinase; pfam01083 478434009729 Cutinase; Region: Cutinase; pfam01083 478434009730 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 478434009731 Pseudouridylate synthase [Translation, ribosomal structure and biogenesis]; Region: TruA; COG0101 478434009732 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 478434009733 dimerization interface 3.5A [polypeptide binding]; other site 478434009734 active site 478434009735 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 478434009736 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 478434009737 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 478434009738 alphaNTD - beta interaction site [polypeptide binding]; other site 478434009739 alphaNTD homodimer interface [polypeptide binding]; other site 478434009740 alphaNTD - beta' interaction site [polypeptide binding]; other site 478434009741 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 478434009742 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 478434009743 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 478434009744 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 478434009745 RNA binding surface [nucleotide binding]; other site 478434009746 30S ribosomal protein S11; Validated; Region: PRK05309 478434009747 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 478434009748 30S ribosomal protein S13; Region: bact_S13; TIGR03631 478434009749 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 478434009750 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 478434009751 rRNA binding site [nucleotide binding]; other site 478434009752 predicted 30S ribosome binding site; other site 478434009753 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 478434009754 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 478434009755 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 478434009756 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 478434009757 NAD binding site [chemical binding]; other site 478434009758 substrate binding site [chemical binding]; other site 478434009759 homodimer interface [polypeptide binding]; other site 478434009760 active site 478434009761 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 478434009762 Domain of unknown function (DUF222); Region: DUF222; pfam02720 478434009763 Domain of unknown function (DUF222); Region: DUF222; pfam02720 478434009764 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 478434009765 active site 478434009766 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 478434009767 extended (e) SDRs; Region: SDR_e; cd08946 478434009768 NAD(P) binding site [chemical binding]; other site 478434009769 active site 478434009770 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 478434009771 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 478434009772 active site 478434009773 catalytic residues [active] 478434009774 metal binding site [ion binding]; metal-binding site 478434009775 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 478434009776 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 478434009777 PYR/PP interface [polypeptide binding]; other site 478434009778 dimer interface [polypeptide binding]; other site 478434009779 TPP binding site [chemical binding]; other site 478434009780 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 478434009781 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 478434009782 TPP-binding site [chemical binding]; other site 478434009783 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 478434009784 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 478434009785 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 478434009786 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 478434009787 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 478434009788 metabolite-proton symporter; Region: 2A0106; TIGR00883 478434009789 putative substrate translocation pore; other site 478434009790 PE family; Region: PE; pfam00934 478434009791 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478434009792 PPE family; Region: PPE; pfam00823 478434009793 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 478434009794 patatin-related protein; Region: TIGR03607 478434009795 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 478434009796 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 478434009797 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 478434009798 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 478434009799 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 478434009800 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 478434009801 Transcriptional regulator [Transcription]; Region: LytR; COG1316 478434009802 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 478434009803 short chain dehydrogenase; Provisional; Region: PRK05875 478434009804 classical (c) SDRs; Region: SDR_c; cd05233 478434009805 NAD(P) binding site [chemical binding]; other site 478434009806 active site 478434009807 Predicted membrane protein [Function unknown]; Region: COG2259 478434009808 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 478434009809 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 478434009810 Predicted transcriptional regulators [Transcription]; Region: COG1695 478434009811 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 478434009812 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 478434009813 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 478434009814 active site 478434009815 homotetramer interface [polypeptide binding]; other site 478434009816 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 478434009817 mce related protein; Region: MCE; pfam02470 478434009818 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 478434009819 mce related protein; Region: MCE; pfam02470 478434009820 mce related protein; Region: MCE; pfam02470 478434009821 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 478434009822 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 478434009823 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 478434009824 mce related protein; Region: MCE; pfam02470 478434009825 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 478434009826 mce related protein; Region: MCE; pfam02470 478434009827 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 478434009828 mce related protein; Region: MCE; pfam02470 478434009829 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 478434009830 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 478434009831 Permease; Region: Permease; pfam02405 478434009832 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 478434009833 Permease; Region: Permease; pfam02405 478434009834 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07792 478434009835 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 478434009836 NAD(P) binding site [chemical binding]; other site 478434009837 active site 478434009838 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 478434009839 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 478434009840 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 478434009841 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 478434009842 FAD binding site [chemical binding]; other site 478434009843 substrate binding site [chemical binding]; other site 478434009844 catalytic base [active] 478434009845 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 478434009846 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 478434009847 active site 478434009848 acyl-CoA synthetase; Validated; Region: PRK07867 478434009849 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 478434009850 acyl-activating enzyme (AAE) consensus motif; other site 478434009851 putative AMP binding site [chemical binding]; other site 478434009852 putative active site [active] 478434009853 putative CoA binding site [chemical binding]; other site 478434009854 PE family; Region: PE; pfam00934 478434009855 PE family; Region: PE; pfam00934 478434009856 hypothetical protein; Validated; Region: PRK07586 478434009857 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 478434009858 PYR/PP interface [polypeptide binding]; other site 478434009859 dimer interface [polypeptide binding]; other site 478434009860 TPP binding site [chemical binding]; other site 478434009861 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 478434009862 TPP-binding site [chemical binding]; other site 478434009863 dimer interface [polypeptide binding]; other site 478434009864 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 478434009865 PE family; Region: PE; pfam00934 478434009866 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 478434009867 CoA binding site [chemical binding]; other site 478434009868 PE family; Region: PE; pfam00934 478434009869 acyl-CoA synthetase; Validated; Region: PRK07798 478434009870 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 478434009871 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 478434009872 acyl-activating enzyme (AAE) consensus motif; other site 478434009873 acyl-activating enzyme (AAE) consensus motif; other site 478434009874 putative AMP binding site [chemical binding]; other site 478434009875 putative active site [active] 478434009876 putative CoA binding site [chemical binding]; other site 478434009877 enoyl-CoA hydratase; Provisional; Region: PRK07799 478434009878 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 478434009879 substrate binding site [chemical binding]; other site 478434009880 oxyanion hole (OAH) forming residues; other site 478434009881 trimer interface [polypeptide binding]; other site 478434009882 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 478434009883 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 478434009884 Cytochrome P450; Region: p450; cl12078 478434009885 Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314 478434009886 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 478434009887 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 478434009888 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 478434009889 DUF35 OB-fold domain; Region: DUF35; pfam01796 478434009890 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 478434009891 DUF35 OB-fold domain; Region: DUF35; pfam01796 478434009892 lipid-transfer protein; Provisional; Region: PRK07937 478434009893 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 478434009894 active site 478434009895 acetyl-CoA acetyltransferase; Provisional; Region: PRK08313 478434009896 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 478434009897 active site 478434009898 NHL repeat; Region: NHL; pfam01436 478434009899 Uncharacterized conserved protein [Function unknown]; Region: COG3391 478434009900 NHL repeat; Region: NHL; pfam01436 478434009901 NHL repeat; Region: NHL; pfam01436 478434009902 NHL repeat; Region: NHL; pfam01436 478434009903 NHL repeat; Region: NHL; pfam01436 478434009904 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 478434009905 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 478434009906 trimer interface [polypeptide binding]; other site 478434009907 putative metal binding site [ion binding]; other site 478434009908 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 478434009909 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 478434009910 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 478434009911 short chain dehydrogenase; Provisional; Region: PRK07890 478434009912 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 478434009913 NAD(P) binding site [chemical binding]; other site 478434009914 active site 478434009915 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478434009916 PPE family; Region: PPE; pfam00823 478434009917 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 478434009918 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478434009919 PPE family; Region: PPE; pfam00823 478434009920 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478434009921 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478434009922 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 478434009923 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 478434009924 active site 478434009925 catalytic residues [active] 478434009926 metal binding site [ion binding]; metal-binding site 478434009927 DmpG-like communication domain; Region: DmpG_comm; pfam07836 478434009928 acetaldehyde dehydrogenase; Validated; Region: PRK08300 478434009929 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 478434009930 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 478434009931 2-keto-4-pentenoate hydratase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3971 478434009932 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843 478434009933 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 478434009934 enoyl-CoA hydratase; Region: PLN02864 478434009935 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 478434009936 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 478434009937 dimer interaction site [polypeptide binding]; other site 478434009938 substrate-binding tunnel; other site 478434009939 active site 478434009940 catalytic site [active] 478434009941 substrate binding site [chemical binding]; other site 478434009942 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478434009943 PPE family; Region: PPE; pfam00823 478434009944 PE-PPE domain; Region: PE-PPE; pfam08237 478434009945 lipid-transfer protein; Provisional; Region: PRK07855 478434009946 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 478434009947 active site 478434009948 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 478434009949 putative active site [active] 478434009950 putative catalytic site [active] 478434009951 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 478434009952 active site 478434009953 catalytic site [active] 478434009954 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 478434009955 DUF35 OB-fold domain; Region: DUF35; pfam01796 478434009956 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 478434009957 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 478434009958 active site 478434009959 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 478434009960 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 478434009961 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 478434009962 active site 478434009963 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 478434009964 Cytochrome P450; Region: p450; cl12078 478434009965 acetyl-CoA acetyltransferase; Provisional; Region: PRK07850 478434009966 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 478434009967 dimer interface [polypeptide binding]; other site 478434009968 active site 478434009969 Domain of unknown function (DUF385); Region: DUF385; pfam04075 478434009970 short chain dehydrogenase; Provisional; Region: PRK07791 478434009971 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 478434009972 homodimer interface [polypeptide binding]; other site 478434009973 NAD binding site [chemical binding]; other site 478434009974 active site 478434009975 short chain dehydrogenase; Provisional; Region: PRK07856 478434009976 classical (c) SDRs; Region: SDR_c; cd05233 478434009977 NAD(P) binding site [chemical binding]; other site 478434009978 active site 478434009979 enoyl-CoA hydratase; Provisional; Region: PRK06495 478434009980 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 478434009981 substrate binding site [chemical binding]; other site 478434009982 oxyanion hole (OAH) forming residues; other site 478434009983 trimer interface [polypeptide binding]; other site 478434009984 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 478434009985 Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit [Lipid metabolism]; Region: AtoA; COG2057 478434009986 Nitronate monooxygenase; Region: NMO; pfam03060 478434009987 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 478434009988 FMN binding site [chemical binding]; other site 478434009989 substrate binding site [chemical binding]; other site 478434009990 putative catalytic residue [active] 478434009991 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 478434009992 Beta-carotene hydroxylase (CrtR), the carotenoid zeaxanthin biosynthetic enzyme catalyzes the addition of hydroxyl groups to the beta-ionone rings of beta-carotene to form zeaxanthin and is found in bacteria and red algae. Carotenoids are important...; Region: CrtR_beta-carotene-hydroxylase; cd03514 478434009993 putative di-iron ligands [ion binding]; other site 478434009994 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 478434009995 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 478434009996 FAD binding pocket [chemical binding]; other site 478434009997 FAD binding motif [chemical binding]; other site 478434009998 phosphate binding motif [ion binding]; other site 478434009999 beta-alpha-beta structure motif; other site 478434010000 NAD(p) ribose binding residues [chemical binding]; other site 478434010001 NAD binding pocket [chemical binding]; other site 478434010002 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 478434010003 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 478434010004 catalytic loop [active] 478434010005 iron binding site [ion binding]; other site 478434010006 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 478434010007 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 478434010008 putative active site [active] 478434010009 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 478434010010 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 478434010011 dimer interface [polypeptide binding]; other site 478434010012 active site 478434010013 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 478434010014 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478434010015 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478434010016 PPE family; Region: PPE; pfam00823 478434010017 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478434010018 short chain dehydrogenase; Provisional; Region: PRK07831 478434010019 classical (c) SDRs; Region: SDR_c; cd05233 478434010020 NAD(P) binding site [chemical binding]; other site 478434010021 active site 478434010022 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 478434010023 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 478434010024 active site 478434010025 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 478434010026 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 478434010027 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 478434010028 acyl-activating enzyme (AAE) consensus motif; other site 478434010029 putative AMP binding site [chemical binding]; other site 478434010030 putative active site [active] 478434010031 putative CoA binding site [chemical binding]; other site 478434010032 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 478434010033 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 478434010034 active site 478434010035 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 478434010036 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 478434010037 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 478434010038 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 478434010039 active site 478434010040 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 478434010041 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 478434010042 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 478434010043 active site 478434010044 aspartate aminotransferase; Provisional; Region: PRK05764 478434010045 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 478434010046 pyridoxal 5'-phosphate binding site [chemical binding]; other site 478434010047 homodimer interface [polypeptide binding]; other site 478434010048 catalytic residue [active] 478434010049 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 478434010050 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 478434010051 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 478434010052 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 478434010053 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 478434010054 active site 478434010055 Fe binding site [ion binding]; other site 478434010056 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 478434010057 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 478434010058 Naphthocyclinone hydroxylase; Region: NcnH; cd01159 478434010059 Flavin binding site [chemical binding]; other site 478434010060 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 478434010061 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 478434010062 FAD binding pocket [chemical binding]; other site 478434010063 FAD binding motif [chemical binding]; other site 478434010064 phosphate binding motif [ion binding]; other site 478434010065 beta-alpha-beta structure motif; other site 478434010066 NAD(p) ribose binding residues [chemical binding]; other site 478434010067 NAD binding pocket [chemical binding]; other site 478434010068 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 478434010069 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 478434010070 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 478434010071 catalytic loop [active] 478434010072 iron binding site [ion binding]; other site 478434010073 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 478434010074 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 478434010075 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 478434010076 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 478434010077 active site 478434010078 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 478434010079 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478434010080 Transcriptional regulators [Transcription]; Region: PurR; COG1609 478434010081 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 478434010082 DNA binding site [nucleotide binding] 478434010083 domain linker motif; other site 478434010084 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 478434010085 putative dimerization interface [polypeptide binding]; other site 478434010086 putative ligand binding site [chemical binding]; other site 478434010087 PknH-like extracellular domain; Region: PknH_C; pfam14032 478434010088 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 478434010089 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 478434010090 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 478434010091 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 478434010092 transmembrane helices; other site 478434010093 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 478434010094 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 478434010095 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 478434010096 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 478434010097 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 478434010098 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 478434010099 active site 478434010100 HIGH motif; other site 478434010101 nucleotide binding site [chemical binding]; other site 478434010102 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 478434010103 KMSKS motif; other site 478434010104 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 478434010105 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 478434010106 homotrimer interaction site [polypeptide binding]; other site 478434010107 zinc binding site [ion binding]; other site 478434010108 CDP-binding sites; other site 478434010109 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 478434010110 substrate binding site; other site 478434010111 dimer interface; other site 478434010112 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 478434010113 DNA repair protein RadA; Provisional; Region: PRK11823 478434010114 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 478434010115 Walker A motif/ATP binding site; other site 478434010116 ATP binding site [chemical binding]; other site 478434010117 Walker B motif; other site 478434010118 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 478434010119 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 478434010120 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 478434010121 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 478434010122 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 478434010123 active site clefts [active] 478434010124 zinc binding site [ion binding]; other site 478434010125 dimer interface [polypeptide binding]; other site 478434010126 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 478434010127 endonuclease III; Region: ENDO3c; smart00478 478434010128 minor groove reading motif; other site 478434010129 helix-hairpin-helix signature motif; other site 478434010130 substrate binding pocket [chemical binding]; other site 478434010131 active site 478434010132 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 478434010133 PE family; Region: PE; pfam00934 478434010134 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 478434010135 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 478434010136 catalytic site [active] 478434010137 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 478434010138 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 478434010139 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 478434010140 Ami_2 domain; Region: Ami_2; smart00644 478434010141 amidase catalytic site [active] 478434010142 Zn binding residues [ion binding]; other site 478434010143 substrate binding site [chemical binding]; other site 478434010144 PE family; Region: PE; pfam00934 478434010145 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 478434010146 Clp amino terminal domain; Region: Clp_N; pfam02861 478434010147 Clp amino terminal domain; Region: Clp_N; pfam02861 478434010148 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 478434010149 Walker A motif; other site 478434010150 ATP binding site [chemical binding]; other site 478434010151 Walker B motif; other site 478434010152 arginine finger; other site 478434010153 UvrB/uvrC motif; Region: UVR; pfam02151 478434010154 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 478434010155 Walker A motif; other site 478434010156 ATP binding site [chemical binding]; other site 478434010157 Walker B motif; other site 478434010158 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 478434010159 Lsr2; Region: Lsr2; pfam11774 478434010160 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 478434010161 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 478434010162 dimer interface [polypeptide binding]; other site 478434010163 putative anticodon binding site; other site 478434010164 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 478434010165 motif 1; other site 478434010166 dimer interface [polypeptide binding]; other site 478434010167 active site 478434010168 motif 2; other site 478434010169 motif 3; other site 478434010170 pantothenate kinase; Reviewed; Region: PRK13318 478434010171 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 478434010172 tetramerization interface [polypeptide binding]; other site 478434010173 active site 478434010174 Pantoate-beta-alanine ligase; Region: PanC; cd00560 478434010175 pantoate--beta-alanine ligase; Region: panC; TIGR00018 478434010176 active site 478434010177 ATP-binding site [chemical binding]; other site 478434010178 pantoate-binding site; other site 478434010179 HXXH motif; other site 478434010180 Rossmann-like domain; Region: Rossmann-like; pfam10727 478434010181 Uncharacterized conserved protein [Function unknown]; Region: COG5495 478434010182 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 478434010183 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 478434010184 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 478434010185 catalytic center binding site [active] 478434010186 ATP binding site [chemical binding]; other site 478434010187 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 478434010188 homooctamer interface [polypeptide binding]; other site 478434010189 active site 478434010190 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 478434010191 dihydropteroate synthase; Region: DHPS; TIGR01496 478434010192 substrate binding pocket [chemical binding]; other site 478434010193 dimer interface [polypeptide binding]; other site 478434010194 inhibitor binding site; inhibition site 478434010195 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 478434010196 homodecamer interface [polypeptide binding]; other site 478434010197 GTP cyclohydrolase I; Provisional; Region: PLN03044 478434010198 active site 478434010199 putative catalytic site residues [active] 478434010200 zinc binding site [ion binding]; other site 478434010201 GTP-CH-I/GFRP interaction surface; other site 478434010202 FtsH Extracellular; Region: FtsH_ext; pfam06480 478434010203 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 478434010204 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 478434010205 Walker A motif; other site 478434010206 ATP binding site [chemical binding]; other site 478434010207 Walker B motif; other site 478434010208 arginine finger; other site 478434010209 Peptidase family M41; Region: Peptidase_M41; pfam01434 478434010210 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 478434010211 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 478434010212 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 478434010213 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 478434010214 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 478434010215 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 478434010216 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 478434010217 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478434010218 PPE family; Region: PPE; pfam00823 478434010219 PE family; Region: PE; pfam00934 478434010220 Uncharacterized conserved protein [Function unknown]; Region: COG2968 478434010221 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 478434010222 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 478434010223 active site 478434010224 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 478434010225 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 478434010226 Ligand Binding Site [chemical binding]; other site 478434010227 Uncharacterized conserved protein [Function unknown]; Region: COG5282 478434010228 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 478434010229 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; pfam02113 478434010230 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 478434010231 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 478434010232 dimer interface [polypeptide binding]; other site 478434010233 substrate binding site [chemical binding]; other site 478434010234 metal binding sites [ion binding]; metal-binding site 478434010235 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2899 478434010236 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 478434010237 Ligand binding site; other site 478434010238 Putative Catalytic site; other site 478434010239 DXD motif; other site 478434010240 Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034 478434010241 Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5285 478434010242 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 478434010243 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 478434010244 NAD(P) binding site [chemical binding]; other site 478434010245 active site 478434010246 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 478434010247 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 478434010248 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 478434010249 transposase; Provisional; Region: PRK06526 478434010250 IstB-like ATP binding protein; Region: IstB_IS21; pfam01695 478434010251 Walker B motif; other site 478434010252 putative transposase OrfB; Reviewed; Region: PHA02517 478434010253 HTH-like domain; Region: HTH_21; pfam13276 478434010254 Integrase core domain; Region: rve; pfam00665 478434010255 Integrase core domain; Region: rve_3; pfam13683 478434010256 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 478434010257 Transposase; Region: HTH_Tnp_1; cl17663 478434010258 Transposase, Mutator family; Region: Transposase_mut; pfam00872 478434010259 MULE transposase domain; Region: MULE; pfam10551 478434010260 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 478434010261 Fic/DOC family; Region: Fic; cl00960 478434010262 VbhA antitoxin and related proteins; Region: VbhA_like; cd11586 478434010263 DNA polymerase III subunit delta'; Validated; Region: PRK07940 478434010264 DNA polymerase III subunit delta'; Validated; Region: PRK08485 478434010265 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 478434010266 dimerization interface [polypeptide binding]; other site 478434010267 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 478434010268 cyclase homology domain; Region: CHD; cd07302 478434010269 nucleotidyl binding site; other site 478434010270 metal binding site [ion binding]; metal-binding site 478434010271 dimer interface [polypeptide binding]; other site 478434010272 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 478434010273 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 478434010274 active site 478434010275 interdomain interaction site; other site 478434010276 putative metal-binding site [ion binding]; other site 478434010277 nucleotide binding site [chemical binding]; other site 478434010278 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 478434010279 domain I; other site 478434010280 phosphate binding site [ion binding]; other site 478434010281 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 478434010282 domain II; other site 478434010283 domain III; other site 478434010284 nucleotide binding site [chemical binding]; other site 478434010285 DNA binding groove [nucleotide binding] 478434010286 catalytic site [active] 478434010287 domain IV; other site 478434010288 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 478434010289 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 478434010290 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 478434010291 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 478434010292 DNA-binding site [nucleotide binding]; DNA binding site 478434010293 RNA-binding motif; other site 478434010294 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 478434010295 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 478434010296 ATP binding site [chemical binding]; other site 478434010297 putative Mg++ binding site [ion binding]; other site 478434010298 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 478434010299 nucleotide binding region [chemical binding]; other site 478434010300 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 478434010301 PE family; Region: PE; pfam00934 478434010302 PE family; Region: PE; pfam00934 478434010303 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 478434010304 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 478434010305 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 478434010306 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 478434010307 Walker A motif; other site 478434010308 ATP binding site [chemical binding]; other site 478434010309 Walker B motif; other site 478434010310 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 478434010311 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 478434010312 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 478434010313 motif II; other site 478434010314 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 478434010315 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 478434010316 Walker A/P-loop; other site 478434010317 ATP binding site [chemical binding]; other site 478434010318 Q-loop/lid; other site 478434010319 ABC transporter signature motif; other site 478434010320 Walker B; other site 478434010321 D-loop; other site 478434010322 H-loop/switch region; other site 478434010323 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 478434010324 Walker A/P-loop; other site 478434010325 ATP binding site [chemical binding]; other site 478434010326 Q-loop/lid; other site 478434010327 ABC transporter signature motif; other site 478434010328 Walker B; other site 478434010329 D-loop; other site 478434010330 H-loop/switch region; other site 478434010331 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 478434010332 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 478434010333 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 478434010334 ABC-ATPase subunit interface; other site 478434010335 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 478434010336 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 478434010337 dimer interface [polypeptide binding]; other site 478434010338 conserved gate region; other site 478434010339 ABC-ATPase subunit interface; other site 478434010340 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 478434010341 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 478434010342 acetyl-CoA synthetase; Provisional; Region: PRK00174 478434010343 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 478434010344 active site 478434010345 CoA binding site [chemical binding]; other site 478434010346 acyl-activating enzyme (AAE) consensus motif; other site 478434010347 AMP binding site [chemical binding]; other site 478434010348 acetate binding site [chemical binding]; other site 478434010349 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 478434010350 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 478434010351 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 478434010352 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 478434010353 putative active site [active] 478434010354 putative CoA binding site [chemical binding]; other site 478434010355 nudix motif; other site 478434010356 metal binding site [ion binding]; metal-binding site 478434010357 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 478434010358 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 478434010359 catalytic residues [active] 478434010360 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 478434010361 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 478434010362 minor groove reading motif; other site 478434010363 helix-hairpin-helix signature motif; other site 478434010364 substrate binding pocket [chemical binding]; other site 478434010365 active site 478434010366 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 478434010367 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 478434010368 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 478434010369 ligand binding site [chemical binding]; other site 478434010370 flexible hinge region; other site 478434010371 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 478434010372 putative switch regulator; other site 478434010373 non-specific DNA interactions [nucleotide binding]; other site 478434010374 DNA binding site [nucleotide binding] 478434010375 sequence specific DNA binding site [nucleotide binding]; other site 478434010376 putative cAMP binding site [chemical binding]; other site 478434010377 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 478434010378 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 478434010379 homotrimer interaction site [polypeptide binding]; other site 478434010380 putative active site [active] 478434010381 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 478434010382 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 478434010383 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 478434010384 P loop; other site 478434010385 Nucleotide binding site [chemical binding]; other site 478434010386 DTAP/Switch II; other site 478434010387 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 478434010388 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 478434010389 DTAP/Switch II; other site 478434010390 Switch I; other site 478434010391 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 478434010392 Transcription factor WhiB; Region: Whib; pfam02467 478434010393 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 478434010394 Transglycosylase; Region: Transgly; pfam00912 478434010395 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 478434010396 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 478434010397 phosphodiesterase YaeI; Provisional; Region: PRK11340 478434010398 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 478434010399 putative active site [active] 478434010400 putative metal binding site [ion binding]; other site 478434010401 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 478434010402 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 478434010403 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 478434010404 catalytic residue [active] 478434010405 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 478434010406 Cytochrome P450; Region: p450; cl12078 478434010407 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 478434010408 anti sigma factor interaction site; other site 478434010409 regulatory phosphorylation site [posttranslational modification]; other site 478434010410 Uncharacterized conserved protein [Function unknown]; Region: COG1610 478434010411 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 478434010412 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 478434010413 MoxR-like ATPases [General function prediction only]; Region: COG0714 478434010414 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 478434010415 Walker A motif; other site 478434010416 ATP binding site [chemical binding]; other site 478434010417 Walker B motif; other site 478434010418 arginine finger; other site 478434010419 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 478434010420 Protein of unknown function DUF58; Region: DUF58; pfam01882 478434010421 Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300 478434010422 Predicted membrane protein/domain [Function unknown]; Region: COG1714 478434010423 glycerol kinase; Provisional; Region: glpK; PRK00047 478434010424 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 478434010425 nucleotide binding site [chemical binding]; other site 478434010426 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 478434010427 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 478434010428 Methyltransferase domain; Region: Methyltransf_23; pfam13489 478434010429 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478434010430 S-adenosylmethionine binding site [chemical binding]; other site 478434010431 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 478434010432 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 478434010433 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 478434010434 catalytic residue [active] 478434010435 Uncharacterized conserved protein [Function unknown]; Region: COG4301 478434010436 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 478434010437 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 478434010438 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 478434010439 putative active site [active] 478434010440 putative dimer interface [polypeptide binding]; other site 478434010441 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 478434010442 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 478434010443 Gamma-glutamylcysteine synthetase [Coenzyme metabolism]; Region: GshA; COG3572 478434010444 PknH-like extracellular domain; Region: PknH_C; pfam14032 478434010445 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 478434010446 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 478434010447 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 478434010448 aspartate kinase; Reviewed; Region: PRK06635 478434010449 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 478434010450 putative nucleotide binding site [chemical binding]; other site 478434010451 putative catalytic residues [active] 478434010452 putative Mg ion binding site [ion binding]; other site 478434010453 putative aspartate binding site [chemical binding]; other site 478434010454 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 478434010455 putative allosteric regulatory site; other site 478434010456 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 478434010457 putative allosteric regulatory residue; other site 478434010458 2-isopropylmalate synthase; Validated; Region: PRK03739 478434010459 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 478434010460 active site 478434010461 catalytic residues [active] 478434010462 metal binding site [ion binding]; metal-binding site 478434010463 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 478434010464 DNA polymerase III subunit epsilon; Provisional; Region: PRK06063 478434010465 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 478434010466 active site 478434010467 catalytic site [active] 478434010468 substrate binding site [chemical binding]; other site 478434010469 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 478434010470 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 478434010471 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 478434010472 catalytic triad [active] 478434010473 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 478434010474 putative active site [active] 478434010475 recombination protein RecR; Reviewed; Region: recR; PRK00076 478434010476 RecR protein; Region: RecR; pfam02132 478434010477 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 478434010478 putative active site [active] 478434010479 putative metal-binding site [ion binding]; other site 478434010480 tetramer interface [polypeptide binding]; other site 478434010481 hypothetical protein; Validated; Region: PRK00153 478434010482 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 478434010483 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 478434010484 active site 478434010485 metal binding site [ion binding]; metal-binding site 478434010486 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 478434010487 hydrophobic ligand binding site; other site 478434010488 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 478434010489 FAD binding domain; Region: FAD_binding_4; pfam01565 478434010490 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 478434010491 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478434010492 S-adenosylmethionine binding site [chemical binding]; other site 478434010493 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14952 478434010494 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 478434010495 Walker A motif; other site 478434010496 ATP binding site [chemical binding]; other site 478434010497 Walker B motif; other site 478434010498 arginine finger; other site 478434010499 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 478434010500 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 478434010501 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 478434010502 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 478434010503 catalytic residue [active] 478434010504 Cutinase; Region: Cutinase; pfam01083 478434010505 Cutinase; Region: Cutinase; pfam01083 478434010506 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 478434010507 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 478434010508 NAD(P) binding site [chemical binding]; other site 478434010509 active site 478434010510 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 478434010511 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH8; cd08262 478434010512 putative NAD(P) binding site [chemical binding]; other site 478434010513 catalytic Zn binding site [ion binding]; other site 478434010514 Uncharacterized conserved protein [Function unknown]; Region: COG3349 478434010515 Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl17487 478434010516 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 478434010517 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 478434010518 putative substrate translocation pore; other site 478434010519 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 478434010520 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 478434010521 ligand binding site [chemical binding]; other site 478434010522 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 478434010523 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 478434010524 active site 478434010525 nucleophile elbow; other site 478434010526 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG1964 478434010527 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 478434010528 FeS/SAM binding site; other site 478434010529 Methyltransferase domain; Region: Methyltransf_31; pfam13847 478434010530 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478434010531 S-adenosylmethionine binding site [chemical binding]; other site 478434010532 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 478434010533 nucleotide binding site [chemical binding]; other site 478434010534 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 478434010535 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 478434010536 active site 478434010537 DNA binding site [nucleotide binding] 478434010538 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 478434010539 DNA binding site [nucleotide binding] 478434010540 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4402 478434010541 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_5; cd04662 478434010542 nudix motif; other site 478434010543 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 478434010544 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 478434010545 Uncharacterized conserved protein [Function unknown]; Region: COG1839 478434010546 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 478434010547 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 478434010548 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 478434010549 Uncharacterized conserved protein [Function unknown]; Region: COG2966 478434010550 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 478434010551 Uncharacterized conserved protein [Function unknown]; Region: COG3610 478434010552 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478434010553 PPE family; Region: PPE; pfam00823 478434010554 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478434010555 PPE family; Region: PPE; pfam00823 478434010556 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 478434010557 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 478434010558 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 478434010559 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 478434010560 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 478434010561 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 478434010562 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 478434010563 Soluble P-type ATPase [General function prediction only]; Region: COG4087 478434010564 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 478434010565 dimerization interface [polypeptide binding]; other site 478434010566 putative DNA binding site [nucleotide binding]; other site 478434010567 putative Zn2+ binding site [ion binding]; other site 478434010568 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3651 478434010569 DNA binding domain, excisionase family; Region: excise; TIGR01764 478434010570 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 478434010571 active site 478434010572 Int/Topo IB signature motif; other site 478434010573 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 478434010574 nucleoside/Zn binding site; other site 478434010575 dimer interface [polypeptide binding]; other site 478434010576 catalytic motif [active] 478434010577 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 478434010578 prephenate dehydrogenase; Validated; Region: PRK06545 478434010579 prephenate dehydrogenase; Validated; Region: PRK08507 478434010580 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3554 478434010581 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 478434010582 ABC-ATPase subunit interface; other site 478434010583 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 478434010584 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 478434010585 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 478434010586 Walker A/P-loop; other site 478434010587 ATP binding site [chemical binding]; other site 478434010588 Q-loop/lid; other site 478434010589 ABC transporter signature motif; other site 478434010590 Walker B; other site 478434010591 D-loop; other site 478434010592 H-loop/switch region; other site 478434010593 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 478434010594 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 478434010595 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 478434010596 putative active site [active] 478434010597 putative substrate binding site [chemical binding]; other site 478434010598 ATP binding site [chemical binding]; other site 478434010599 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 478434010600 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 478434010601 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 478434010602 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 478434010603 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 478434010604 dimerization interface [polypeptide binding]; other site 478434010605 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 478434010606 dimer interface [polypeptide binding]; other site 478434010607 phosphorylation site [posttranslational modification] 478434010608 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 478434010609 ATP binding site [chemical binding]; other site 478434010610 Mg2+ binding site [ion binding]; other site 478434010611 G-X-G motif; other site 478434010612 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 478434010613 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 478434010614 active site 478434010615 phosphorylation site [posttranslational modification] 478434010616 intermolecular recognition site; other site 478434010617 dimerization interface [polypeptide binding]; other site 478434010618 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 478434010619 DNA binding site [nucleotide binding] 478434010620 Photosystem II reaction centre W protein (PsbW); Region: PsbW; cl06243 478434010621 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 478434010622 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 478434010623 SnoaL-like domain; Region: SnoaL_2; pfam12680 478434010624 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 478434010625 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 478434010626 pyridoxal 5'-phosphate binding site [chemical binding]; other site 478434010627 homodimer interface [polypeptide binding]; other site 478434010628 catalytic residue [active] 478434010629 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 478434010630 TIGR03086 family protein; Region: TIGR03086 478434010631 enoyl-CoA hydratase; Provisional; Region: PRK06142 478434010632 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 478434010633 substrate binding site [chemical binding]; other site 478434010634 oxyanion hole (OAH) forming residues; other site 478434010635 trimer interface [polypeptide binding]; other site 478434010636 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 478434010637 Beta-lactamase; Region: Beta-lactamase; pfam00144 478434010638 potential protein location (hypothetical protein [Mycobacterium tuberculosis KZN 1435]) that overlaps RNA (tRNA-S) 478434010639 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 478434010640 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 478434010641 NAD(P) binding site [chemical binding]; other site 478434010642 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 478434010643 cysteine desulfurase family protein, VC1184 subfamily; Region: am_tr_V_VC1184; TIGR01976 478434010644 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 478434010645 catalytic residue [active] 478434010646 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 478434010647 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 478434010648 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 478434010649 Walker A/P-loop; other site 478434010650 ATP binding site [chemical binding]; other site 478434010651 Q-loop/lid; other site 478434010652 ABC transporter signature motif; other site 478434010653 Walker B; other site 478434010654 D-loop; other site 478434010655 H-loop/switch region; other site 478434010656 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 478434010657 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 478434010658 active site 478434010659 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 478434010660 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 478434010661 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 478434010662 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 478434010663 NAD binding site [chemical binding]; other site 478434010664 substrate binding site [chemical binding]; other site 478434010665 active site 478434010666 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 478434010667 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 478434010668 active site 478434010669 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 478434010670 Peptidase family M23; Region: Peptidase_M23; pfam01551 478434010671 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 478434010672 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 478434010673 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05892 478434010674 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 478434010675 Predicted membrane protein [Function unknown]; Region: COG2246 478434010676 GtrA-like protein; Region: GtrA; pfam04138 478434010677 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 478434010678 FAD binding domain; Region: FAD_binding_4; pfam01565 478434010679 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 478434010680 short chain dehydrogenase; Provisional; Region: PRK07904 478434010681 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 478434010682 NAD(P) binding site [chemical binding]; other site 478434010683 active site 478434010684 Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250 478434010685 Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249 478434010686 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 478434010687 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 478434010688 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 478434010689 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 478434010690 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 478434010691 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 478434010692 FAD binding site [chemical binding]; other site 478434010693 substrate binding site [chemical binding]; other site 478434010694 catalytic residues [active] 478434010695 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 478434010696 Transposase; Region: DDE_Tnp_ISL3; pfam01610 478434010697 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 478434010698 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 478434010699 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 478434010700 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 478434010701 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 478434010702 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 478434010703 active site 478434010704 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 478434010705 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 478434010706 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 478434010707 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 478434010708 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 478434010709 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 478434010710 acyl-activating enzyme (AAE) consensus motif; other site 478434010711 active site 478434010712 Cutinase; Region: Cutinase; pfam01083 478434010713 Predicted esterase [General function prediction only]; Region: COG0627 478434010714 Putative esterase; Region: Esterase; pfam00756 478434010715 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 478434010716 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 478434010717 active site 478434010718 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 478434010719 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 478434010720 active site 478434010721 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 478434010722 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 478434010723 UDP-galactopyranose mutase; Region: GLF; pfam03275 478434010724 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 478434010725 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 478434010726 amidase catalytic site [active] 478434010727 Zn binding residues [ion binding]; other site 478434010728 substrate binding site [chemical binding]; other site 478434010729 LGFP repeat; Region: LGFP; pfam08310 478434010730 PE family; Region: PE; pfam00934 478434010731 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 478434010732 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 478434010733 active site 478434010734 motif I; other site 478434010735 motif II; other site 478434010736 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 478434010737 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 478434010738 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 478434010739 putative acyl-acceptor binding pocket; other site 478434010740 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 478434010741 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 478434010742 putative acyl-acceptor binding pocket; other site 478434010743 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 478434010744 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 478434010745 putative acyl-acceptor binding pocket; other site 478434010746 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 478434010747 Phosphotransferase enzyme family; Region: APH; pfam01636 478434010748 active site 478434010749 ATP binding site [chemical binding]; other site 478434010750 antibiotic binding site [chemical binding]; other site 478434010751 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 478434010752 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 478434010753 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 478434010754 iron-sulfur cluster [ion binding]; other site 478434010755 [2Fe-2S] cluster binding site [ion binding]; other site 478434010756 Condensation domain; Region: Condensation; pfam00668 478434010757 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 478434010758 PE-PPE domain; Region: PE-PPE; pfam08237 478434010759 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 478434010760 Condensation domain; Region: Condensation; pfam00668 478434010761 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 478434010762 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 478434010763 active site 478434010764 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 478434010765 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 478434010766 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 478434010767 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 478434010768 Enoylreductase; Region: PKS_ER; smart00829 478434010769 NAD(P) binding site [chemical binding]; other site 478434010770 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 478434010771 KR domain; Region: KR; pfam08659 478434010772 putative NADP binding site [chemical binding]; other site 478434010773 active site 478434010774 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 478434010775 acyl-CoA synthetase; Validated; Region: PRK05850 478434010776 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 478434010777 acyl-activating enzyme (AAE) consensus motif; other site 478434010778 active site 478434010779 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 478434010780 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 478434010781 Probable transposase; Region: OrfB_IS605; pfam01385 478434010782 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 478434010783 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 478434010784 catalytic residues [active] 478434010785 catalytic nucleophile [active] 478434010786 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 478434010787 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 478434010788 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 478434010789 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478434010790 Protein of unknown function (DUF2834); Region: DUF2834; pfam11196 478434010791 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478434010792 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 478434010793 Cupin domain; Region: Cupin_2; cl17218 478434010794 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 478434010795 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 478434010796 seryl-tRNA synthetase; Provisional; Region: PRK05431 478434010797 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 478434010798 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 478434010799 dimer interface [polypeptide binding]; other site 478434010800 active site 478434010801 motif 1; other site 478434010802 motif 2; other site 478434010803 motif 3; other site 478434010804 Septum formation; Region: Septum_form; pfam13845 478434010805 Septum formation; Region: Septum_form; pfam13845 478434010806 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 478434010807 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 478434010808 catalytic core [active] 478434010809 prephenate dehydratase; Provisional; Region: PRK11898 478434010810 Prephenate dehydratase; Region: PDT; pfam00800 478434010811 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 478434010812 putative L-Phe binding site [chemical binding]; other site 478434010813 Transcriptional regulator [Transcription]; Region: LytR; COG1316 478434010814 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 478434010815 Ferritin-like domain; Region: Ferritin; pfam00210 478434010816 ferroxidase diiron center [ion binding]; other site 478434010817 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582 478434010818 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 478434010819 putative active site [active] 478434010820 catalytic site [active] 478434010821 putative metal binding site [ion binding]; other site 478434010822 Domain of unknown function (DUF4328); Region: DUF4328; pfam14219 478434010823 Transposase; Region: DEDD_Tnp_IS110; pfam01548 478434010824 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 478434010825 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 478434010826 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 478434010827 Predicted membrane protein [Function unknown]; Region: COG2119 478434010828 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 478434010829 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 478434010830 Fimbrial protein; Region: Fimbrial; cl01416 478434010831 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 478434010832 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 478434010833 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 478434010834 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 478434010835 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478434010836 hypothetical protein; Provisional; Region: PRK07945 478434010837 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 478434010838 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 478434010839 active site 478434010840 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 478434010841 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 478434010842 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 478434010843 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 478434010844 active site 478434010845 dimer interface [polypeptide binding]; other site 478434010846 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 478434010847 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 478434010848 active site 478434010849 FMN binding site [chemical binding]; other site 478434010850 substrate binding site [chemical binding]; other site 478434010851 3Fe-4S cluster binding site [ion binding]; other site 478434010852 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 478434010853 domain interface; other site 478434010854 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 478434010855 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 478434010856 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 478434010857 EspG family; Region: ESX-1_EspG; pfam14011 478434010858 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 478434010859 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 478434010860 Walker A motif; other site 478434010861 ATP binding site [chemical binding]; other site 478434010862 Walker B motif; other site 478434010863 arginine finger; other site 478434010864 Protein of unknown function (DUF690); Region: DUF690; pfam05108 478434010865 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 478434010866 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 478434010867 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 478434010868 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 478434010869 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 478434010870 PE family; Region: PE; pfam00934 478434010871 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478434010872 PPE family; Region: PPE; pfam00823 478434010873 Proteins of 100 residues with WXG; Region: WXG100; cl02005 478434010874 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 478434010875 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 478434010876 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 478434010877 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 478434010878 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 478434010879 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 478434010880 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 478434010881 active site 478434010882 catalytic residues [active] 478434010883 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 478434010884 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 478434010885 Walker A motif; other site 478434010886 ATP binding site [chemical binding]; other site 478434010887 Walker B motif; other site 478434010888 arginine finger; other site 478434010889 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 478434010890 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 478434010891 catalytic residues [active] 478434010892 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 478434010893 active site 478434010894 catalytic residues [active] 478434010895 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 478434010896 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 478434010897 EspG family; Region: ESX-1_EspG; pfam14011 478434010898 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 478434010899 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 478434010900 PPE family; Region: PPE; pfam00823 478434010901 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 478434010902 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 478434010903 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 478434010904 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 478434010905 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 478434010906 Protein of unknown function (DUF690); Region: DUF690; pfam05108 478434010907 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 478434010908 N-acetyl-D-glucosamine binding site [chemical binding]; other site 478434010909 catalytic residue [active] 478434010910 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 478434010911 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 478434010912 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 478434010913 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 478434010914 active site 478434010915 NTP binding site [chemical binding]; other site 478434010916 metal binding triad [ion binding]; metal-binding site 478434010917 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 478434010918 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 478434010919 Zn2+ binding site [ion binding]; other site 478434010920 Mg2+ binding site [ion binding]; other site 478434010921 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 478434010922 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 478434010923 active site 478434010924 Ap6A binding site [chemical binding]; other site 478434010925 nudix motif; other site 478434010926 metal binding site [ion binding]; metal-binding site 478434010927 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 478434010928 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 478434010929 RNA polymerase sigma factor SigM; Reviewed; Region: PRK09643 478434010930 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 478434010931 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 478434010932 DNA binding residues [nucleotide binding] 478434010933 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 478434010934 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 478434010935 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 478434010936 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 478434010937 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 478434010938 catalytic residues [active] 478434010939 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 478434010940 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 478434010941 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 478434010942 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 478434010943 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 478434010944 active site 478434010945 metal binding site [ion binding]; metal-binding site 478434010946 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 478434010947 ParB-like nuclease domain; Region: ParB; smart00470 478434010948 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 478434010949 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 478434010950 P-loop; other site 478434010951 Magnesium ion binding site [ion binding]; other site 478434010952 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 478434010953 Magnesium ion binding site [ion binding]; other site 478434010954 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; cl17726 478434010955 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 478434010956 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 478434010957 G-X-X-G motif; other site 478434010958 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 478434010959 RxxxH motif; other site 478434010960 putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449 478434010961 Uncharacterized conserved protein [Function unknown]; Region: COG0759 478434010962 ribonuclease P; Reviewed; Region: rnpA; PRK00588 478434010963 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399