-- dump date 20140619_155002 -- class Genbank::misc_feature -- table misc_feature_note -- id note 478433000001 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 478433000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 478433000003 Walker A motif; other site 478433000004 ATP binding site [chemical binding]; other site 478433000005 Walker B motif; other site 478433000006 arginine finger; other site 478433000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 478433000008 DnaA box-binding interface [nucleotide binding]; other site 478433000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 478433000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 478433000011 putative DNA binding surface [nucleotide binding]; other site 478433000012 dimer interface [polypeptide binding]; other site 478433000013 beta-clamp/clamp loader binding surface; other site 478433000014 beta-clamp/translesion DNA polymerase binding surface; other site 478433000015 recF protein; Region: recf; TIGR00611 478433000016 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 478433000017 Walker A/P-loop; other site 478433000018 ATP binding site [chemical binding]; other site 478433000019 Q-loop/lid; other site 478433000020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 478433000021 ABC transporter signature motif; other site 478433000022 Walker B; other site 478433000023 D-loop; other site 478433000024 H-loop/switch region; other site 478433000025 hypothetical protein; Provisional; Region: PRK03195 478433000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 478433000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 478433000028 Mg2+ binding site [ion binding]; other site 478433000029 G-X-G motif; other site 478433000030 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 478433000031 anchoring element; other site 478433000032 dimer interface [polypeptide binding]; other site 478433000033 ATP binding site [chemical binding]; other site 478433000034 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 478433000035 active site 478433000036 putative metal-binding site [ion binding]; other site 478433000037 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 478433000038 DNA gyrase subunit A; Validated; Region: PRK05560 478433000039 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 478433000040 CAP-like domain; other site 478433000041 active site 478433000042 primary dimer interface [polypeptide binding]; other site 478433000043 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 478433000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 478433000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 478433000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 478433000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 478433000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 478433000049 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 478433000050 Protein of unknown function (DUF2562); Region: DUF2562; pfam10814 478433000051 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 478433000052 active site 478433000053 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 478433000054 putative septation inhibitor protein; Reviewed; Region: PRK00159 478433000055 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 478433000056 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 478433000057 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 478433000058 Glutamine amidotransferase class-I; Region: GATase; pfam00117 478433000059 glutamine binding [chemical binding]; other site 478433000060 catalytic triad [active] 478433000061 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 478433000062 Catalytic domain of Protein Kinases; Region: PKc; cd00180 478433000063 active site 478433000064 ATP binding site [chemical binding]; other site 478433000065 substrate binding site [chemical binding]; other site 478433000066 activation loop (A-loop); other site 478433000067 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 478433000068 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 478433000069 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 478433000070 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 478433000071 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 478433000072 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 478433000073 Catalytic domain of Protein Kinases; Region: PKc; cd00180 478433000074 active site 478433000075 ATP binding site [chemical binding]; other site 478433000076 substrate binding site [chemical binding]; other site 478433000077 activation loop (A-loop); other site 478433000078 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 478433000079 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 478433000080 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 478433000081 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 478433000082 active site 478433000083 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 478433000084 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 478433000085 phosphopeptide binding site; other site 478433000086 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 478433000087 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 478433000088 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 478433000089 phosphopeptide binding site; other site 478433000090 Nitronate monooxygenase; Region: NMO; pfam03060 478433000091 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 478433000092 FMN binding site [chemical binding]; other site 478433000093 substrate binding site [chemical binding]; other site 478433000094 putative catalytic residue [active] 478433000095 Transcription factor WhiB; Region: Whib; pfam02467 478433000096 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 478433000097 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 478433000098 non-specific DNA binding site [nucleotide binding]; other site 478433000099 salt bridge; other site 478433000100 sequence-specific DNA binding site [nucleotide binding]; other site 478433000101 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 478433000102 NlpC/P60 family; Region: NLPC_P60; pfam00877 478433000103 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 478433000104 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 478433000105 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 478433000106 Protein of unknown function (DUF2694); Region: DUF2694; pfam10904 478433000107 Protein of unknown function (DUF2710); Region: DUF2710; pfam10921 478433000108 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 478433000109 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 478433000110 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 478433000111 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 478433000112 catalytic residue [active] 478433000113 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 478433000114 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 478433000115 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 478433000116 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 478433000117 acyl-activating enzyme (AAE) consensus motif; other site 478433000118 active site 478433000119 TIGR03084 family protein; Region: TIGR03084 478433000120 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 478433000121 Wyosine base formation; Region: Wyosine_form; pfam08608 478433000122 H+ Antiporter protein; Region: 2A0121; TIGR00900 478433000123 hypothetical protein; Validated; Region: PRK00228 478433000124 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 478433000125 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 478433000126 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 478433000127 active site 478433000128 HIGH motif; other site 478433000129 nucleotide binding site [chemical binding]; other site 478433000130 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 478433000131 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 478433000132 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 478433000133 active site 478433000134 KMSKS motif; other site 478433000135 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 478433000136 tRNA binding surface [nucleotide binding]; other site 478433000137 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 478433000138 MarR family; Region: MarR; pfam01047 478433000139 Transcriptional regulators [Transcription]; Region: FadR; COG2186 478433000140 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 478433000141 DNA-binding site [nucleotide binding]; DNA binding site 478433000142 probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856 478433000143 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 478433000144 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 478433000145 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 478433000146 inositol 1-phosphate synthase, Actinobacterial type; Region: mycothiol_INO1; TIGR03450 478433000147 Predicted transcriptional regulators [Transcription]; Region: COG1695 478433000148 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 478433000149 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 478433000150 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 478433000151 Transglycosylase; Region: Transgly; pfam00912 478433000152 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 478433000153 Predicted integral membrane protein [Function unknown]; Region: COG5650 478433000154 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 478433000155 conserved cys residue [active] 478433000156 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 478433000157 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 478433000158 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 478433000159 dimer interface [polypeptide binding]; other site 478433000160 ssDNA binding site [nucleotide binding]; other site 478433000161 tetramer (dimer of dimers) interface [polypeptide binding]; other site 478433000162 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 478433000163 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 478433000164 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 478433000165 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 478433000166 replicative DNA helicase; Validated; Region: PRK07773 478433000167 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 478433000168 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 478433000169 Walker A motif; other site 478433000170 ATP binding site [chemical binding]; other site 478433000171 Walker B motif; other site 478433000172 DNA binding loops [nucleotide binding] 478433000173 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 478433000174 protein-splicing catalytic site; other site 478433000175 thioester formation/cholesterol transfer; other site 478433000176 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 478433000177 protein-splicing catalytic site; other site 478433000178 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 478433000179 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 478433000180 ADP-ribose binding site [chemical binding]; other site 478433000181 Predicted phosphatase homologous to the C-terminal domain of histone macroH2A1 [General function prediction only]; Region: COG2110 478433000182 Cellobiohydrolase A (1,4-beta-cellobiosidase A) [Carbohydrate transport and metabolism]; Region: CelA; COG5297 478433000183 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 478433000184 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 478433000185 FAD binding domain; Region: FAD_binding_4; pfam01565 478433000186 Berberine and berberine like; Region: BBE; pfam08031 478433000187 hypothetical protein; Provisional; Region: PRK12438 478433000188 hypothetical protein; Validated; Region: PRK00068 478433000189 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 478433000190 homotetrameric interface [polypeptide binding]; other site 478433000191 putative active site [active] 478433000192 metal binding site [ion binding]; metal-binding site 478433000193 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 478433000194 Monomeric isocitrate dehydrogenase; Region: IDH; pfam03971 478433000195 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 478433000196 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478433000197 short chain dehydrogenase; Provisional; Region: PRK06197 478433000198 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 478433000199 putative NAD(P) binding site [chemical binding]; other site 478433000200 active site 478433000201 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 478433000202 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 478433000203 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 478433000204 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 478433000205 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 478433000206 dimer interface [polypeptide binding]; other site 478433000207 active site 478433000208 glycine-pyridoxal phosphate binding site [chemical binding]; other site 478433000209 folate binding site [chemical binding]; other site 478433000210 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 478433000211 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 478433000212 putative NTP binding site [chemical binding]; other site 478433000213 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 478433000214 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 478433000215 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 478433000216 Walker A/P-loop; other site 478433000217 ATP binding site [chemical binding]; other site 478433000218 Q-loop/lid; other site 478433000219 ABC transporter signature motif; other site 478433000220 Walker B; other site 478433000221 D-loop; other site 478433000222 H-loop/switch region; other site 478433000223 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 478433000224 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 478433000225 ligand binding site [chemical binding]; other site 478433000226 flexible hinge region; other site 478433000227 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 478433000228 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 478433000229 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 478433000230 active site 478433000231 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 478433000232 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 478433000233 pyridoxal 5'-phosphate binding site [chemical binding]; other site 478433000234 homodimer interface [polypeptide binding]; other site 478433000235 catalytic residue [active] 478433000236 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 478433000237 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 478433000238 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478433000239 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 478433000240 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 478433000241 dimerization interface [polypeptide binding]; other site 478433000242 putative DNA binding site [nucleotide binding]; other site 478433000243 putative Zn2+ binding site [ion binding]; other site 478433000244 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 478433000245 hydrogenase 4 subunit B; Validated; Region: PRK06521 478433000246 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 478433000247 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 478433000248 NADH dehydrogenase; Region: NADHdh; cl00469 478433000249 Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; COG4237 478433000250 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 478433000251 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 478433000252 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 478433000253 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 478433000254 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825 478433000255 putative hydrophobic ligand binding site [chemical binding]; other site 478433000256 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478433000257 S-adenosylmethionine binding site [chemical binding]; other site 478433000258 Predicted membrane protein [Function unknown]; Region: COG3305 478433000259 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 478433000260 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 478433000261 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 478433000262 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 478433000263 metal-binding site [ion binding] 478433000264 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 478433000265 Soluble P-type ATPase [General function prediction only]; Region: COG4087 478433000266 Predicted integral membrane protein [Function unknown]; Region: COG5660 478433000267 Putative zinc-finger; Region: zf-HC2; pfam13490 478433000268 Domain of unknown function (DUF222); Region: DUF222; pfam02720 478433000269 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 478433000270 active site 478433000271 Domain of unknown function (DUF222); Region: DUF222; pfam02720 478433000272 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478433000273 PPE family; Region: PPE; pfam00823 478433000274 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 478433000275 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 478433000276 FcoT-like thioesterase domain; Region: FcoT; pfam10862 478433000277 acyl-CoA synthetase; Validated; Region: PRK05857 478433000278 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 478433000279 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 478433000280 acyl-activating enzyme (AAE) consensus motif; other site 478433000281 acyl-activating enzyme (AAE) consensus motif; other site 478433000282 AMP binding site [chemical binding]; other site 478433000283 active site 478433000284 CoA binding site [chemical binding]; other site 478433000285 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 478433000286 AMP-binding enzyme; Region: AMP-binding; pfam00501 478433000287 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 478433000288 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 478433000289 acyl-activating enzyme (AAE) consensus motif; other site 478433000290 acyl-activating enzyme (AAE) consensus motif; other site 478433000291 active site 478433000292 AMP binding site [chemical binding]; other site 478433000293 CoA binding site [chemical binding]; other site 478433000294 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 478433000295 Condensation domain; Region: Condensation; pfam00668 478433000296 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 478433000297 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 478433000298 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 478433000299 acyl-activating enzyme (AAE) consensus motif; other site 478433000300 AMP binding site [chemical binding]; other site 478433000301 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 478433000302 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 478433000303 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 478433000304 putative NAD(P) binding site [chemical binding]; other site 478433000305 active site 478433000306 putative substrate binding site [chemical binding]; other site 478433000307 Predicted membrane protein [Function unknown]; Region: COG3336 478433000308 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 478433000309 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 478433000310 metal-binding site [ion binding] 478433000311 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 478433000312 Soluble P-type ATPase [General function prediction only]; Region: COG4087 478433000313 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 478433000314 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 478433000315 ligand binding site [chemical binding]; other site 478433000316 flexible hinge region; other site 478433000317 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 478433000318 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 478433000319 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 478433000320 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 478433000321 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 478433000322 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 478433000323 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 478433000324 motif II; other site 478433000325 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 478433000326 PE family; Region: PE; pfam00934 478433000327 B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction; Region: BBOX; cl00034 478433000328 Rhomboid family; Region: Rhomboid; pfam01694 478433000329 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 478433000330 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 478433000331 active site 478433000332 catalytic triad [active] 478433000333 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 478433000334 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 478433000335 NADP-binding site; other site 478433000336 homotetramer interface [polypeptide binding]; other site 478433000337 substrate binding site [chemical binding]; other site 478433000338 homodimer interface [polypeptide binding]; other site 478433000339 active site 478433000340 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 478433000341 dimer interface [polypeptide binding]; other site 478433000342 active site 478433000343 histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656 478433000344 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 478433000345 active site 478433000346 motif I; other site 478433000347 motif II; other site 478433000348 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 478433000349 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 478433000350 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 478433000351 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 478433000352 Transcriptional regulator [Transcription]; Region: LysR; COG0583 478433000353 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 478433000354 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 478433000355 dimerization interface [polypeptide binding]; other site 478433000356 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 478433000357 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 478433000358 PYR/PP interface [polypeptide binding]; other site 478433000359 dimer interface [polypeptide binding]; other site 478433000360 TPP binding site [chemical binding]; other site 478433000361 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 478433000362 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 478433000363 TPP-binding site; other site 478433000364 dimer interface [polypeptide binding]; other site 478433000365 acyl-CoA synthetase; Validated; Region: PRK05852 478433000366 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 478433000367 Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; Region: FACL_fum10p_like; cd05926 478433000368 acyl-activating enzyme (AAE) consensus motif; other site 478433000369 acyl-activating enzyme (AAE) consensus motif; other site 478433000370 putative AMP binding site [chemical binding]; other site 478433000371 putative active site [active] 478433000372 putative CoA binding site [chemical binding]; other site 478433000373 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 478433000374 elongation factor G; Reviewed; Region: PRK12740 478433000375 G1 box; other site 478433000376 putative GEF interaction site [polypeptide binding]; other site 478433000377 GTP/Mg2+ binding site [chemical binding]; other site 478433000378 Switch I region; other site 478433000379 G2 box; other site 478433000380 G3 box; other site 478433000381 Switch II region; other site 478433000382 G4 box; other site 478433000383 G5 box; other site 478433000384 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 478433000385 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 478433000386 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 478433000387 PPOX class probable F420-dependent enzyme, Rv0121 family; Region: Rv0121_F420; TIGR03668 478433000388 PE family; Region: PE; pfam00934 478433000389 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 478433000390 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 478433000391 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 478433000392 trehalose synthase; Region: treS_nterm; TIGR02456 478433000393 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 478433000394 active site 478433000395 catalytic site [active] 478433000396 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 478433000397 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 478433000398 Predicted membrane protein [Function unknown]; Region: COG3619 478433000399 Predicted esterase [General function prediction only]; Region: COG0627 478433000400 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 478433000401 putative active site [active] 478433000402 putative catalytic site [active] 478433000403 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 478433000404 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 478433000405 active site 478433000406 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 478433000407 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 478433000408 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 478433000409 Coenzyme A binding pocket [chemical binding]; other site 478433000410 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 478433000411 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 478433000412 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 478433000413 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478433000414 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 478433000415 Cytochrome P450; Region: p450; cl12078 478433000416 methionine sulfoxide reductase A; Provisional; Region: PRK14054 478433000417 SnoaL-like domain; Region: SnoaL_2; pfam12680 478433000418 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 478433000419 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 478433000420 NAD(P) binding site [chemical binding]; other site 478433000421 active site 478433000422 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 478433000423 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 478433000424 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 478433000425 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 478433000426 minor groove reading motif; other site 478433000427 helix-hairpin-helix signature motif; other site 478433000428 active site 478433000429 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 478433000430 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 478433000431 Cl- selectivity filter; other site 478433000432 Cl- binding residues [ion binding]; other site 478433000433 pore gating glutamate residue; other site 478433000434 dimer interface [polypeptide binding]; other site 478433000435 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 478433000436 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478433000437 Leucine carboxyl methyltransferase; Region: LCM; cl01306 478433000438 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 478433000439 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 478433000440 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 478433000441 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 478433000442 NAD(P) binding site [chemical binding]; other site 478433000443 catalytic residues [active] 478433000444 short chain dehydrogenase; Provisional; Region: PRK07791 478433000445 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 478433000446 NAD binding site [chemical binding]; other site 478433000447 homodimer interface [polypeptide binding]; other site 478433000448 active site 478433000449 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 478433000450 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 478433000451 NAD(P) binding site [chemical binding]; other site 478433000452 PE family; Region: PE; pfam00934 478433000453 PE-PPE domain; Region: PE-PPE; pfam08237 478433000454 PE-PPE domain; Region: PE-PPE; pfam08237 478433000455 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 478433000456 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 478433000457 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 478433000458 Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155 478433000459 FAD binding site [chemical binding]; other site 478433000460 substrate binding site [chemical binding]; other site 478433000461 catalytic base [active] 478433000462 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 478433000463 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 478433000464 ligand binding site [chemical binding]; other site 478433000465 homodimer interface [polypeptide binding]; other site 478433000466 NAD(P) binding site [chemical binding]; other site 478433000467 trimer interface B [polypeptide binding]; other site 478433000468 trimer interface A [polypeptide binding]; other site 478433000469 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 478433000470 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 478433000471 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 478433000472 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 478433000473 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 478433000474 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478433000475 QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360 478433000476 PE family; Region: PE; pfam00934 478433000477 PE-PPE domain; Region: PE-PPE; pfam08237 478433000478 PE family; Region: PE; pfam00934 478433000479 PE-PPE domain; Region: PE-PPE; pfam08237 478433000480 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 478433000481 FAD binding domain; Region: FAD_binding_4; pfam01565 478433000482 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 478433000483 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 478433000484 NAD(P) binding site [chemical binding]; other site 478433000485 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 478433000486 active site 478433000487 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 478433000488 putative hydrophobic ligand binding site [chemical binding]; other site 478433000489 Transcriptional regulators [Transcription]; Region: GntR; COG1802 478433000490 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 478433000491 DNA-binding site [nucleotide binding]; DNA binding site 478433000492 FCD domain; Region: FCD; pfam07729 478433000493 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07786 478433000494 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 478433000495 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 478433000496 acyl-activating enzyme (AAE) consensus motif; other site 478433000497 acyl-activating enzyme (AAE) consensus motif; other site 478433000498 putative AMP binding site [chemical binding]; other site 478433000499 putative active site [active] 478433000500 putative CoA binding site [chemical binding]; other site 478433000501 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 478433000502 Permease; Region: Permease; pfam02405 478433000503 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 478433000504 Permease; Region: Permease; pfam02405 478433000505 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 478433000506 mce related protein; Region: MCE; pfam02470 478433000507 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 478433000508 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 478433000509 mce related protein; Region: MCE; pfam02470 478433000510 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 478433000511 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 478433000512 mce related protein; Region: MCE; pfam02470 478433000513 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 478433000514 mce related protein; Region: MCE; pfam02470 478433000515 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 478433000516 mce related protein; Region: MCE; pfam02470 478433000517 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 478433000518 mce related protein; Region: MCE; pfam02470 478433000519 RDD family; Region: RDD; pfam06271 478433000520 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 478433000521 Predicted membrane protein [Function unknown]; Region: COG1511 478433000522 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 478433000523 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 478433000524 Pirin-related protein [General function prediction only]; Region: COG1741 478433000525 Pirin; Region: Pirin; pfam02678 478433000526 RNA polymerase factor sigma-70; Validated; Region: PRK08241 478433000527 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 478433000528 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 478433000529 DNA binding residues [nucleotide binding] 478433000530 SnoaL-like domain; Region: SnoaL_2; pfam12680 478433000531 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 478433000532 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 478433000533 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 478433000534 putative metallohydrolase, TIGR04338 family; Region: HEXXH_Rv0185 478433000535 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 478433000536 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 478433000537 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 478433000538 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 478433000539 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 478433000540 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478433000541 S-adenosylmethionine binding site [chemical binding]; other site 478433000542 SPW repeat; Region: SPW; pfam03779 478433000543 SPW repeat; Region: SPW; pfam03779 478433000544 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 478433000545 6-phosphogluconate dehydratase; Region: edd; TIGR01196 478433000546 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 478433000547 putative homodimer interface [polypeptide binding]; other site 478433000548 putative homotetramer interface [polypeptide binding]; other site 478433000549 putative allosteric switch controlling residues; other site 478433000550 putative metal binding site [ion binding]; other site 478433000551 putative homodimer-homodimer interface [polypeptide binding]; other site 478433000552 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 478433000553 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 478433000554 putative substrate translocation pore; other site 478433000555 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 478433000556 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 478433000557 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 478433000558 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 478433000559 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 478433000560 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 478433000561 Walker A/P-loop; other site 478433000562 ATP binding site [chemical binding]; other site 478433000563 Q-loop/lid; other site 478433000564 ABC transporter signature motif; other site 478433000565 Walker B; other site 478433000566 D-loop; other site 478433000567 H-loop/switch region; other site 478433000568 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 478433000569 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 478433000570 Walker A/P-loop; other site 478433000571 ATP binding site [chemical binding]; other site 478433000572 Q-loop/lid; other site 478433000573 ABC transporter signature motif; other site 478433000574 Walker B; other site 478433000575 D-loop; other site 478433000576 H-loop/switch region; other site 478433000577 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 478433000578 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 478433000579 dimerization interface [polypeptide binding]; other site 478433000580 DNA binding residues [nucleotide binding] 478433000581 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 478433000582 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478433000583 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 478433000584 The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762 478433000585 putative [Fe4-S4] binding site [ion binding]; other site 478433000586 putative molybdopterin cofactor binding site [chemical binding]; other site 478433000587 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 478433000588 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 478433000589 putative molybdopterin cofactor binding site; other site 478433000590 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 478433000591 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 478433000592 active site 478433000593 Zn binding site [ion binding]; other site 478433000594 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 478433000595 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 478433000596 Predicted integral membrane protein [Function unknown]; Region: COG0392 478433000597 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 478433000598 Domain of unknown function DUF20; Region: UPF0118; pfam01594 478433000599 MMPL family; Region: MMPL; pfam03176 478433000600 MMPL family; Region: MMPL; pfam03176 478433000601 LabA_like proteins; Region: LabA_like; cd06167 478433000602 putative metal binding site [ion binding]; other site 478433000603 Putative methyltransferase; Region: Methyltransf_4; pfam02390 478433000604 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 478433000605 active site 478433000606 substrate-binding site [chemical binding]; other site 478433000607 metal-binding site [ion binding] 478433000608 GTP binding site [chemical binding]; other site 478433000609 nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526 478433000610 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 478433000611 active site 478433000612 (T/H)XGH motif; other site 478433000613 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 478433000614 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 478433000615 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 478433000616 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 478433000617 FeS/SAM binding site; other site 478433000618 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 478433000619 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 478433000620 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 478433000621 acyl-activating enzyme (AAE) consensus motif; other site 478433000622 acyl-activating enzyme (AAE) consensus motif; other site 478433000623 putative AMP binding site [chemical binding]; other site 478433000624 putative active site [active] 478433000625 putative CoA binding site [chemical binding]; other site 478433000626 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 478433000627 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 478433000628 active site 478433000629 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 478433000630 putative active site [active] 478433000631 putative catalytic site [active] 478433000632 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 478433000633 active site 2 [active] 478433000634 active site 1 [active] 478433000635 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 478433000636 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 478433000637 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 478433000638 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cd00321 478433000639 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 478433000640 Moco binding site; other site 478433000641 metal coordination site [ion binding]; other site 478433000642 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 478433000643 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 478433000644 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 478433000645 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 478433000646 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 478433000647 enoyl-CoA hydratase; Provisional; Region: PRK08252 478433000648 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 478433000649 substrate binding site [chemical binding]; other site 478433000650 oxyanion hole (OAH) forming residues; other site 478433000651 trimer interface [polypeptide binding]; other site 478433000652 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 478433000653 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 478433000654 NAD binding site [chemical binding]; other site 478433000655 catalytic residues [active] 478433000656 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478433000657 S-adenosylmethionine binding site [chemical binding]; other site 478433000658 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 478433000659 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 478433000660 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 478433000661 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 478433000662 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 478433000663 putative active site [active] 478433000664 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 478433000665 active site 478433000666 substrate binding pocket [chemical binding]; other site 478433000667 homodimer interaction site [polypeptide binding]; other site 478433000668 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 478433000669 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 478433000670 active site 478433000671 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 478433000672 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478433000673 Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain; Region: RNRR2_Rv0233_like; cd07911 478433000674 active site 478433000675 diiron metal binding site [ion binding]; other site 478433000676 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 478433000677 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 478433000678 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 478433000679 NAD(P) binding site [chemical binding]; other site 478433000680 catalytic residues [active] 478433000681 Lipase maturation factor; Region: LMF1; pfam06762 478433000682 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 478433000683 Protein of unknown function (DUF2613); Region: DUF2613; pfam11021 478433000684 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 478433000685 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 478433000686 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 478433000687 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478433000688 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 478433000689 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 478433000690 MaoC like domain; Region: MaoC_dehydratas; pfam01575 478433000691 active site 2 [active] 478433000692 active site 1 [active] 478433000693 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 478433000694 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 478433000695 NAD(P) binding site [chemical binding]; other site 478433000696 active site 478433000697 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 478433000698 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 478433000699 dimer interface [polypeptide binding]; other site 478433000700 active site 478433000701 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 478433000702 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 478433000703 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 478433000704 FAD binding site [chemical binding]; other site 478433000705 substrate binding site [chemical binding]; other site 478433000706 catalytic residues [active] 478433000707 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 478433000708 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 478433000709 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386 478433000710 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 478433000711 catalytic loop [active] 478433000712 iron binding site [ion binding]; other site 478433000713 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803 478433000714 L-aspartate oxidase; Provisional; Region: PRK06175 478433000715 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 478433000716 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 478433000717 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 478433000718 putative dimer interface [polypeptide binding]; other site 478433000719 nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374 478433000720 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 478433000721 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 478433000722 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 478433000723 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 478433000724 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 478433000725 homotrimer interface [polypeptide binding]; other site 478433000726 Walker A motif; other site 478433000727 GTP binding site [chemical binding]; other site 478433000728 Walker B motif; other site 478433000729 cobyric acid synthase; Provisional; Region: PRK00784 478433000730 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 478433000731 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 478433000732 catalytic triad [active] 478433000733 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478433000734 PPE family; Region: PPE; pfam00823 478433000735 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 478433000736 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 478433000737 putative active site [active] 478433000738 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 478433000739 putative active site [active] 478433000740 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 478433000741 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 478433000742 active site 478433000743 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 478433000744 DNA binding site [nucleotide binding] 478433000745 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 478433000746 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 478433000747 Coenzyme A binding pocket [chemical binding]; other site 478433000748 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 478433000749 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 478433000750 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 478433000751 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 478433000752 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 478433000753 intersubunit interface [polypeptide binding]; other site 478433000754 5-oxoprolinase; Region: PLN02666 478433000755 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 478433000756 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 478433000757 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 478433000758 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 478433000759 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 478433000760 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 478433000761 nucleotide binding site [chemical binding]; other site 478433000762 acyl-CoA synthetase; Validated; Region: PRK07788 478433000763 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 478433000764 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 478433000765 active site 478433000766 CoA binding site [chemical binding]; other site 478433000767 AMP binding site [chemical binding]; other site 478433000768 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 478433000769 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 478433000770 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 478433000771 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 478433000772 FAD binding site [chemical binding]; other site 478433000773 substrate binding site [chemical binding]; other site 478433000774 catalytic base [active] 478433000775 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 478433000776 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 478433000777 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478433000778 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 478433000779 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 478433000780 Zn binding site [ion binding]; other site 478433000781 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 478433000782 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 478433000783 putative active site [active] 478433000784 PE family; Region: PE; pfam00934 478433000785 PE family; Region: PE; pfam00934 478433000786 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478433000787 PPE family; Region: PPE; pfam00823 478433000788 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478433000789 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 478433000790 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 478433000791 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 478433000792 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 478433000793 Walker A motif; other site 478433000794 ATP binding site [chemical binding]; other site 478433000795 Walker B motif; other site 478433000796 arginine finger; other site 478433000797 Protein of unknown function (DUF690); Region: DUF690; pfam05108 478433000798 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 478433000799 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 478433000800 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 478433000801 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 478433000802 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 478433000803 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478433000804 PPE family; Region: PPE; pfam00823 478433000805 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 478433000806 EspG family; Region: ESX-1_EspG; pfam14011 478433000807 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 478433000808 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 478433000809 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 478433000810 active site 478433000811 catalytic residues [active] 478433000812 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 478433000813 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 478433000814 Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752 478433000815 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 478433000816 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478433000817 S-adenosylmethionine binding site [chemical binding]; other site 478433000818 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4424 478433000819 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 478433000820 Sulfatase; Region: Sulfatase; cl17466 478433000821 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 478433000822 putative active site [active] 478433000823 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 478433000824 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478433000825 light-dependent protochlorophyllide reductase (LPOR)-like, classical (c)-like SDRs; Region: LPOR_like_SDR_c_like; cd09810 478433000826 protochlorophyllide reductase; Region: PLN00015 478433000827 putative NAD(P) binding site [chemical binding]; other site 478433000828 active site 478433000829 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478433000830 PPE family; Region: PPE; pfam00823 478433000831 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478433000832 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478433000833 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478433000834 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478433000835 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478433000836 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478433000837 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478433000838 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478433000839 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478433000840 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478433000841 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478433000842 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478433000843 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 478433000844 putative FMN binding site [chemical binding]; other site 478433000845 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 478433000846 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 478433000847 active site 478433000848 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 478433000849 SnoaL-like domain; Region: SnoaL_4; pfam13577 478433000850 SnoaL-like domain; Region: SnoaL_3; pfam13474 478433000851 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 478433000852 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 478433000853 nucleotide binding site [chemical binding]; other site 478433000854 Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones]; Region: HtpG; COG0326 478433000855 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 478433000856 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 478433000857 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 478433000858 active site 478433000859 catalytic residues [active] 478433000860 Muconolactone delta-isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CatC1; COG4829 478433000861 Muconolactone delta-isomerase; Region: MIase; cl01992 478433000862 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 478433000863 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 478433000864 putative active site [active] 478433000865 catalytic site [active] 478433000866 putative metal binding site [ion binding]; other site 478433000867 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 478433000868 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 478433000869 putative substrate binding pocket [chemical binding]; other site 478433000870 AC domain interface; other site 478433000871 catalytic triad [active] 478433000872 AB domain interface; other site 478433000873 interchain disulfide; other site 478433000874 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 478433000875 trimer interface [polypeptide binding]; other site 478433000876 active site 478433000877 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 478433000878 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 478433000879 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 478433000880 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 478433000881 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 478433000882 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 478433000883 dimerization interface [polypeptide binding]; other site 478433000884 putative DNA binding site [nucleotide binding]; other site 478433000885 putative Zn2+ binding site [ion binding]; other site 478433000886 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 478433000887 active site residue [active] 478433000888 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478433000889 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 478433000890 Cytochrome P450; Region: p450; cl12078 478433000891 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 478433000892 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478433000893 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 478433000894 Methyltransferase domain; Region: Methyltransf_23; pfam13489 478433000895 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478433000896 S-adenosylmethionine binding site [chemical binding]; other site 478433000897 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 478433000898 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478433000899 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 478433000900 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 478433000901 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 478433000902 SnoaL-like domain; Region: SnoaL_2; pfam12680 478433000903 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 478433000904 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 478433000905 substrate binding site; other site 478433000906 tetramer interface; other site 478433000907 PE family; Region: PE; pfam00934 478433000908 Domain of unknown function (DUF222); Region: DUF222; pfam02720 478433000909 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 478433000910 active site 478433000911 aminotransferase AlaT; Validated; Region: PRK09265 478433000912 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 478433000913 pyridoxal 5'-phosphate binding site [chemical binding]; other site 478433000914 homodimer interface [polypeptide binding]; other site 478433000915 catalytic residue [active] 478433000916 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 478433000917 4Fe-4S binding domain; Region: Fer4; pfam00037 478433000918 Cysteine-rich domain; Region: CCG; pfam02754 478433000919 Cysteine-rich domain; Region: CCG; pfam02754 478433000920 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 478433000921 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 478433000922 DNA binding residues [nucleotide binding] 478433000923 dimerization interface [polypeptide binding]; other site 478433000924 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 478433000925 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 478433000926 G1 box; other site 478433000927 GTP/Mg2+ binding site [chemical binding]; other site 478433000928 G2 box; other site 478433000929 Switch I region; other site 478433000930 G3 box; other site 478433000931 Switch II region; other site 478433000932 G4 box; other site 478433000933 G5 box; other site 478433000934 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 478433000935 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 478433000936 G1 box; other site 478433000937 GTP/Mg2+ binding site [chemical binding]; other site 478433000938 G2 box; other site 478433000939 Switch I region; other site 478433000940 G3 box; other site 478433000941 Switch II region; other site 478433000942 Uncharacterized MobA-related protein [General function prediction only]; Region: COG2068 478433000943 active site 478433000944 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 478433000945 TIGR04255 family protein; Region: sporadTIGR04255 478433000946 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 478433000947 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 478433000948 nucleotide binding site [chemical binding]; other site 478433000949 NEF interaction site [polypeptide binding]; other site 478433000950 SBD interface [polypeptide binding]; other site 478433000951 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 478433000952 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 478433000953 dimer interface [polypeptide binding]; other site 478433000954 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 478433000955 chaperone protein DnaJ; Provisional; Region: PRK14279 478433000956 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 478433000957 HSP70 interaction site [polypeptide binding]; other site 478433000958 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 478433000959 Zn binding sites [ion binding]; other site 478433000960 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 478433000961 dimer interface [polypeptide binding]; other site 478433000962 Helix-Turn-Helix DNA binding domain of HspR-like transcription regulators; Region: HTH_HspR-like; cd01279 478433000963 DNA binding residues [nucleotide binding] 478433000964 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 478433000965 putative dimer interface [polypeptide binding]; other site 478433000966 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478433000967 PPE family; Region: PPE; pfam00823 478433000968 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478433000969 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478433000970 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478433000971 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478433000972 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 478433000973 CoenzymeA binding site [chemical binding]; other site 478433000974 subunit interaction site [polypeptide binding]; other site 478433000975 PHB binding site; other site 478433000976 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 478433000977 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 478433000978 GDP-binding site [chemical binding]; other site 478433000979 ACT binding site; other site 478433000980 IMP binding site; other site 478433000981 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 478433000982 Peptidase family M50; Region: Peptidase_M50; pfam02163 478433000983 active site 478433000984 putative substrate binding region [chemical binding]; other site 478433000985 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 478433000986 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 478433000987 MgtE intracellular N domain; Region: MgtE_N; pfam03448 478433000988 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 478433000989 Divalent cation transporter; Region: MgtE; pfam01769 478433000990 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 478433000991 fructose-bisphosphate aldolase, class II, yeast/E. coli subtype; Region: FruBisAldo_II_A; TIGR01520 478433000992 active site 478433000993 intersubunit interface [polypeptide binding]; other site 478433000994 zinc binding site [ion binding]; other site 478433000995 Na+ binding site [ion binding]; other site 478433000996 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 478433000997 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 478433000998 Predicted glycosyl hydrolase [Carbohydrate transport and metabolism]; Region: COG4833 478433000999 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 478433001000 AAA domain; Region: AAA_33; pfam13671 478433001001 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 478433001002 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 478433001003 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 478433001004 putative hydrophobic ligand binding site [chemical binding]; other site 478433001005 MoxR-like ATPases [General function prediction only]; Region: COG0714 478433001006 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 478433001007 Ligand binding site; other site 478433001008 metal-binding site 478433001009 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 478433001010 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 478433001011 XdhC Rossmann domain; Region: XdhC_C; pfam13478 478433001012 carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416 478433001013 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 478433001014 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 478433001015 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 478433001016 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 478433001017 catalytic loop [active] 478433001018 iron binding site [ion binding]; other site 478433001019 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 478433001020 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 478433001021 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 478433001022 Uncharacterized conserved protein [Function unknown]; Region: COG3360 478433001023 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 478433001024 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 478433001025 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 478433001026 active site 478433001027 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 478433001028 Clp amino terminal domain; Region: Clp_N; pfam02861 478433001029 Clp amino terminal domain; Region: Clp_N; pfam02861 478433001030 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 478433001031 Walker A motif; other site 478433001032 ATP binding site [chemical binding]; other site 478433001033 Walker B motif; other site 478433001034 arginine finger; other site 478433001035 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 478433001036 Walker A motif; other site 478433001037 ATP binding site [chemical binding]; other site 478433001038 Walker B motif; other site 478433001039 arginine finger; other site 478433001040 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 478433001041 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 478433001042 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 478433001043 heme-binding site [chemical binding]; other site 478433001044 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 478433001045 FAD binding pocket [chemical binding]; other site 478433001046 FAD binding motif [chemical binding]; other site 478433001047 phosphate binding motif [ion binding]; other site 478433001048 beta-alpha-beta structure motif; other site 478433001049 NAD binding pocket [chemical binding]; other site 478433001050 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 478433001051 cyclase homology domain; Region: CHD; cd07302 478433001052 nucleotidyl binding site; other site 478433001053 metal binding site [ion binding]; metal-binding site 478433001054 dimer interface [polypeptide binding]; other site 478433001055 Predicted ATPase [General function prediction only]; Region: COG3903 478433001056 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 478433001057 Walker A motif; other site 478433001058 ATP binding site [chemical binding]; other site 478433001059 Walker B motif; other site 478433001060 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 478433001061 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 478433001062 DNA binding residues [nucleotide binding] 478433001063 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478433001064 PPE family; Region: PPE; pfam00823 478433001065 Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase) [Nucleotide transport and metabolism]; Region: PurT; COG0027 478433001066 ATP-grasp domain; Region: ATP-grasp_4; cl17255 478433001067 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 478433001068 active site residue [active] 478433001069 O-succinylhomoserine sulfhydrylase; Provisional; Region: PRK07810 478433001070 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 478433001071 homodimer interface [polypeptide binding]; other site 478433001072 substrate-cofactor binding pocket; other site 478433001073 pyridoxal 5'-phosphate binding site [chemical binding]; other site 478433001074 catalytic residue [active] 478433001075 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 478433001076 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 478433001077 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 478433001078 Domain of unknown function (DUF222); Region: DUF222; pfam02720 478433001079 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 478433001080 active site 478433001081 PLD-like domain; Region: PLDc_2; pfam13091 478433001082 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 478433001083 Beta-lactamase; Region: Beta-lactamase; pfam00144 478433001084 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 478433001085 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 478433001086 FAD binding site [chemical binding]; other site 478433001087 substrate binding pocket [chemical binding]; other site 478433001088 catalytic base [active] 478433001089 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 478433001090 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 478433001091 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 478433001092 acyl-CoA synthetase; Validated; Region: PRK05850 478433001093 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 478433001094 acyl-activating enzyme (AAE) consensus motif; other site 478433001095 active site 478433001096 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 478433001097 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 478433001098 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 478433001099 active site 478433001100 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 478433001101 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 478433001102 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 478433001103 Thioesterase; Region: PKS_TE; smart00824 478433001104 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 478433001105 glucose-6-phosphate dehydrogenase (coenzyme-F420); Region: F420_G6P_DH; TIGR03554 478433001106 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 478433001107 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 478433001108 phosphate acetyltransferase; Reviewed; Region: PRK05632 478433001109 DRTGG domain; Region: DRTGG; pfam07085 478433001110 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 478433001111 propionate/acetate kinase; Provisional; Region: PRK12379 478433001112 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 478433001113 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 478433001114 Catalytic domain of Protein Kinases; Region: PKc; cd00180 478433001115 active site 478433001116 ATP binding site [chemical binding]; other site 478433001117 substrate binding site [chemical binding]; other site 478433001118 activation loop (A-loop); other site 478433001119 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 478433001120 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 478433001121 substrate binding pocket [chemical binding]; other site 478433001122 membrane-bound complex binding site; other site 478433001123 hinge residues; other site 478433001124 NUDIX domain; Region: NUDIX; pfam00293 478433001125 nudix motif; other site 478433001126 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 478433001127 thiamine phosphate binding site [chemical binding]; other site 478433001128 active site 478433001129 pyrophosphate binding site [ion binding]; other site 478433001130 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 478433001131 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 478433001132 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 478433001133 thiS-thiF/thiG interaction site; other site 478433001134 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 478433001135 ThiS interaction site; other site 478433001136 putative active site [active] 478433001137 tetramer interface [polypeptide binding]; other site 478433001138 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 478433001139 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 478433001140 PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH. Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816 478433001141 PA/protease or protease-like domain interface [polypeptide binding]; other site 478433001142 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 478433001143 active site 478433001144 metal binding site [ion binding]; metal-binding site 478433001145 Predicted metalloprotease [General function prediction only]; Region: COG2321 478433001146 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 478433001147 Zn binding site [ion binding]; other site 478433001148 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 478433001149 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 478433001150 dimer interface [polypeptide binding]; other site 478433001151 substrate binding site [chemical binding]; other site 478433001152 ATP binding site [chemical binding]; other site 478433001153 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 478433001154 ThiC-associated domain; Region: ThiC-associated; pfam13667 478433001155 ThiC family; Region: ThiC; pfam01964 478433001156 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 478433001157 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 478433001158 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 478433001159 motif II; other site 478433001160 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 478433001161 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 478433001162 putative catalytic site [active] 478433001163 putative phosphate binding site [ion binding]; other site 478433001164 active site 478433001165 metal binding site A [ion binding]; metal-binding site 478433001166 DNA binding site [nucleotide binding] 478433001167 putative AP binding site [nucleotide binding]; other site 478433001168 putative metal binding site B [ion binding]; other site 478433001169 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 478433001170 active site 478433001171 catalytic residues [active] 478433001172 metal binding site [ion binding]; metal-binding site 478433001173 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 478433001174 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 478433001175 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 478433001176 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 478433001177 E-class dimer interface [polypeptide binding]; other site 478433001178 P-class dimer interface [polypeptide binding]; other site 478433001179 active site 478433001180 Cu2+ binding site [ion binding]; other site 478433001181 Zn2+ binding site [ion binding]; other site 478433001182 carboxylate-amine ligase; Provisional; Region: PRK13517 478433001183 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 478433001184 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 478433001185 AAA family ATPase, CDC48 subfamily; Region: CDC48; TIGR01243 478433001186 Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359 478433001187 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 478433001188 Walker A motif; other site 478433001189 ATP binding site [chemical binding]; other site 478433001190 Walker B motif; other site 478433001191 arginine finger; other site 478433001192 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 478433001193 Walker A motif; other site 478433001194 ATP binding site [chemical binding]; other site 478433001195 Walker B motif; other site 478433001196 arginine finger; other site 478433001197 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 478433001198 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 478433001199 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 478433001200 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 478433001201 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 478433001202 dimer interface [polypeptide binding]; other site 478433001203 putative functional site; other site 478433001204 putative MPT binding site; other site 478433001205 short chain dehydrogenase; Provisional; Region: PRK06197 478433001206 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 478433001207 putative NAD(P) binding site [chemical binding]; other site 478433001208 active site 478433001209 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 478433001210 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 478433001211 ring oligomerisation interface [polypeptide binding]; other site 478433001212 ATP/Mg binding site [chemical binding]; other site 478433001213 stacking interactions; other site 478433001214 hinge regions; other site 478433001215 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478433001216 PPE family; Region: PPE; pfam00823 478433001217 Protein of unknown function (DUF664); Region: DUF664; pfam04978 478433001218 DinB superfamily; Region: DinB_2; pfam12867 478433001219 putative anti-sigmaE protein; Provisional; Region: PRK13920 478433001220 Anti-sigma-K factor rskA; Region: RskA; pfam10099 478433001221 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 478433001222 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 478433001223 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 478433001224 DNA binding residues [nucleotide binding] 478433001225 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 478433001226 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 478433001227 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 478433001228 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478433001229 S-adenosylmethionine binding site [chemical binding]; other site 478433001230 Uncharacterized conserved protein [Function unknown]; Region: COG3496 478433001231 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 478433001232 Subunit A of Class III extradiol dioxygenases; Region: Extradiol_Dioxygenase_3A_like; cl06673 478433001233 dimer interface [polypeptide binding]; other site 478433001234 Transport protein; Region: actII; TIGR00833 478433001235 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 478433001236 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 478433001237 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478433001238 PPE family; Region: PPE; pfam00823 478433001239 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478433001240 Protein of unknown function (DUF2782); Region: DUF2782; pfam11191 478433001241 enoyl-CoA hydratase; Provisional; Region: PRK12478 478433001242 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 478433001243 substrate binding site [chemical binding]; other site 478433001244 oxyanion hole (OAH) forming residues; other site 478433001245 trimer interface [polypeptide binding]; other site 478433001246 PemK-like protein; Region: PemK; pfam02452 478433001247 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 478433001248 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 478433001249 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 478433001250 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 478433001251 NAD(P) binding site [chemical binding]; other site 478433001252 catalytic residues [active] 478433001253 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3564 478433001254 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 478433001255 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 478433001256 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 478433001257 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 478433001258 Uncharacterized conserved protein [Function unknown]; Region: COG2128 478433001259 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 478433001260 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 478433001261 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 478433001262 non-specific DNA binding site [nucleotide binding]; other site 478433001263 salt bridge; other site 478433001264 sequence-specific DNA binding site [nucleotide binding]; other site 478433001265 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 478433001266 Domain of unknown function (DUF955); Region: DUF955; pfam06114 478433001267 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 478433001268 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 478433001269 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 478433001270 active site 478433001271 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 478433001272 active site 2 [active] 478433001273 isocitrate lyase; Provisional; Region: PRK15063 478433001274 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cd06556 478433001275 oligomerization interface [polypeptide binding]; other site 478433001276 active site 478433001277 metal binding site [ion binding]; metal-binding site 478433001278 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 478433001279 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 478433001280 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 478433001281 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 478433001282 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478433001283 S-adenosylmethionine binding site [chemical binding]; other site 478433001284 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 478433001285 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 478433001286 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478433001287 S-adenosylmethionine binding site [chemical binding]; other site 478433001288 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224 478433001289 UbiA prenyltransferase family; Region: UbiA; pfam01040 478433001290 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 478433001291 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478433001292 Predicted membrane protein [Function unknown]; Region: COG2733 478433001293 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 478433001294 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 478433001295 non-specific DNA binding site [nucleotide binding]; other site 478433001296 salt bridge; other site 478433001297 sequence-specific DNA binding site [nucleotide binding]; other site 478433001298 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 478433001299 Protein of unknown function (DUF2599); Region: DUF2599; pfam10783 478433001300 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 478433001301 intersubunit interface [polypeptide binding]; other site 478433001302 active site 478433001303 catalytic residue [active] 478433001304 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 478433001305 Predicted amidohydrolase [General function prediction only]; Region: COG0388 478433001306 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 478433001307 putative active site [active] 478433001308 catalytic triad [active] 478433001309 putative dimer interface [polypeptide binding]; other site 478433001310 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 478433001311 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 478433001312 FAD binding domain; Region: FAD_binding_4; pfam01565 478433001313 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 478433001314 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 478433001315 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 478433001316 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 478433001317 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 478433001318 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 478433001319 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 478433001320 NAD(P) binding site [chemical binding]; other site 478433001321 active site 478433001322 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 478433001323 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 478433001324 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 478433001325 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 478433001326 putative ADP-binding pocket [chemical binding]; other site 478433001327 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 478433001328 L-lysine exporter; Region: 2a75; TIGR00948 478433001329 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 478433001330 catalytic core [active] 478433001331 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 478433001332 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 478433001333 dimer interface [polypeptide binding]; other site 478433001334 phosphorylation site [posttranslational modification] 478433001335 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 478433001336 ATP binding site [chemical binding]; other site 478433001337 Mg2+ binding site [ion binding]; other site 478433001338 G-X-G motif; other site 478433001339 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 478433001340 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 478433001341 active site 478433001342 phosphorylation site [posttranslational modification] 478433001343 intermolecular recognition site; other site 478433001344 dimerization interface [polypeptide binding]; other site 478433001345 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 478433001346 DNA binding site [nucleotide binding] 478433001347 GMC oxidoreductase; Region: GMC_oxred_N; pfam00732 478433001348 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 478433001349 Transcriptional regulators [Transcription]; Region: FadR; COG2186 478433001350 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 478433001351 DNA-binding site [nucleotide binding]; DNA binding site 478433001352 FCD domain; Region: FCD; pfam07729 478433001353 exopolyphosphatase; Region: exo_poly_only; TIGR03706 478433001354 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 478433001355 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 478433001356 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 478433001357 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 478433001358 Diacylglycerol kinase catalytic domain (presumed); Region: DAGKc; smart00046 478433001359 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 478433001360 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 478433001361 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 478433001362 DNA binding domain, excisionase family; Region: excise; TIGR01764 478433001363 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 478433001364 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 478433001365 putative NAD(P) binding site [chemical binding]; other site 478433001366 active site 478433001367 putative substrate binding site [chemical binding]; other site 478433001368 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 478433001369 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 478433001370 putative acyl-acceptor binding pocket; other site 478433001371 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 478433001372 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 478433001373 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478433001374 S-adenosylmethionine binding site [chemical binding]; other site 478433001375 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 478433001376 active site 478433001377 catalytic site [active] 478433001378 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 478433001379 HAD-superfamily subfamily IB hydrolase, TIGR01490; Region: HAD-SF-IB-hyp1 478433001380 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 478433001381 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 478433001382 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 478433001383 glutamyl-tRNA reductase; Region: hemA; TIGR01035 478433001384 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 478433001385 tRNA; other site 478433001386 putative tRNA binding site [nucleotide binding]; other site 478433001387 putative NADP binding site [chemical binding]; other site 478433001388 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 478433001389 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 478433001390 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 478433001391 domain interfaces; other site 478433001392 active site 478433001393 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 478433001394 active site 478433001395 homodimer interface [polypeptide binding]; other site 478433001396 SAM binding site [chemical binding]; other site 478433001397 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 478433001398 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 478433001399 active site 478433001400 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 478433001401 dimer interface [polypeptide binding]; other site 478433001402 active site 478433001403 Schiff base residues; other site 478433001404 Domain of unknown function (DUF222); Region: DUF222; pfam02720 478433001405 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 478433001406 active site 478433001407 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 478433001408 anti sigma factor interaction site; other site 478433001409 regulatory phosphorylation site [posttranslational modification]; other site 478433001410 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 478433001411 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 478433001412 active site 478433001413 catalytic triad [active] 478433001414 oxyanion hole [active] 478433001415 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 478433001416 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478433001417 Methyltransferase domain; Region: Methyltransf_31; pfam13847 478433001418 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 478433001419 Domain of unknown function (DUF385); Region: DUF385; pfam04075 478433001420 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 478433001421 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 478433001422 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 478433001423 catalytic residue [active] 478433001424 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 478433001425 catalytic core [active] 478433001426 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 478433001427 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 478433001428 catalytic residues [active] 478433001429 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 478433001430 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 478433001431 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 478433001432 ResB-like family; Region: ResB; pfam05140 478433001433 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 478433001434 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 478433001435 AAA domain; Region: AAA_31; pfam13614 478433001436 P-loop; other site 478433001437 Magnesium ion binding site [ion binding]; other site 478433001438 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 478433001439 Protein of unknown function (DUF4229); Region: DUF4229; pfam14012 478433001440 3-oxoacyl-(acyl-carrier-protein) synthase III; Region: fabH; TIGR00747 478433001441 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 478433001442 dimer interface [polypeptide binding]; other site 478433001443 active site 478433001444 CoA binding pocket [chemical binding]; other site 478433001445 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Region: menA; TIGR00751 478433001446 UbiA prenyltransferase family; Region: UbiA; pfam01040 478433001447 5'-methylthioadenosine phosphorylase; Validated; Region: PRK07823 478433001448 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 478433001449 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 478433001450 NAD(P) binding site [chemical binding]; other site 478433001451 active site 478433001452 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 478433001453 Ligand binding site; other site 478433001454 Putative Catalytic site; other site 478433001455 DXD motif; other site 478433001456 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3222 478433001457 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 478433001458 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 478433001459 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 478433001460 acyl-activating enzyme (AAE) consensus motif; other site 478433001461 acyl-activating enzyme (AAE) consensus motif; other site 478433001462 AMP binding site [chemical binding]; other site 478433001463 active site 478433001464 CoA binding site [chemical binding]; other site 478433001465 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 478433001466 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 478433001467 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 478433001468 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 478433001469 active site 478433001470 short chain dehydrogenase; Provisional; Region: PRK05866 478433001471 classical (c) SDRs; Region: SDR_c; cd05233 478433001472 NAD(P) binding site [chemical binding]; other site 478433001473 active site 478433001474 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 478433001475 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 478433001476 substrate binding site [chemical binding]; other site 478433001477 oxyanion hole (OAH) forming residues; other site 478433001478 trimer interface [polypeptide binding]; other site 478433001479 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 478433001480 putative active site [active] 478433001481 homotetrameric interface [polypeptide binding]; other site 478433001482 metal binding site [ion binding]; metal-binding site 478433001483 acyl-CoA synthetase; Validated; Region: PRK06188 478433001484 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 478433001485 putative active site [active] 478433001486 putative CoA binding site [chemical binding]; other site 478433001487 putative AMP binding site [chemical binding]; other site 478433001488 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 478433001489 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 478433001490 active site 478433001491 O-succinylbenzoate synthase; Provisional; Region: PRK02901 478433001492 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 478433001493 active site 478433001494 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 478433001495 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 478433001496 TAP-like protein; Region: Abhydrolase_4; pfam08386 478433001497 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 478433001498 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 478433001499 dimer interface [polypeptide binding]; other site 478433001500 tetramer interface [polypeptide binding]; other site 478433001501 PYR/PP interface [polypeptide binding]; other site 478433001502 TPP binding site [chemical binding]; other site 478433001503 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 478433001504 TPP-binding site; other site 478433001505 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 478433001506 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 478433001507 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 478433001508 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 478433001509 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478433001510 S-adenosylmethionine binding site [chemical binding]; other site 478433001511 Protein of unknown function (DUF732); Region: DUF732; pfam05305 478433001512 Methyltransferase domain; Region: Methyltransf_23; pfam13489 478433001513 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478433001514 S-adenosylmethionine binding site [chemical binding]; other site 478433001515 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 478433001516 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 478433001517 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 478433001518 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 478433001519 substrate binding pocket [chemical binding]; other site 478433001520 chain length determination region; other site 478433001521 substrate-Mg2+ binding site; other site 478433001522 catalytic residues [active] 478433001523 aspartate-rich region 1; other site 478433001524 active site lid residues [active] 478433001525 aspartate-rich region 2; other site 478433001526 heat shock protein HtpX; Provisional; Region: PRK03072 478433001527 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK12439 478433001528 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 478433001529 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 478433001530 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 478433001531 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 478433001532 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 478433001533 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 478433001534 O-methyltransferase; Region: Methyltransf_2; pfam00891 478433001535 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 478433001536 Cytochrome P450; Region: p450; cl12078 478433001537 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 478433001538 ATP cone domain; Region: ATP-cone; pfam03477 478433001539 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 478433001540 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 478433001541 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 478433001542 active site 478433001543 dimer interface [polypeptide binding]; other site 478433001544 effector binding site; other site 478433001545 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 478433001546 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 478433001547 active site 478433001548 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 478433001549 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 478433001550 nicotinate phosphoribosyltransferase; Provisional; Region: PRK12484 478433001551 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 478433001552 active site 478433001553 Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane]; Region: PgsA; COG2843 478433001554 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 478433001555 putative active site [active] 478433001556 putative metal binding site [ion binding]; other site 478433001557 hypothetical protein; Provisional; Region: PRK07588 478433001558 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 478433001559 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 478433001560 dimerization interface [polypeptide binding]; other site 478433001561 putative DNA binding site [nucleotide binding]; other site 478433001562 putative Zn2+ binding site [ion binding]; other site 478433001563 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 478433001564 putative hydrophobic ligand binding site [chemical binding]; other site 478433001565 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 478433001566 TIGR03086 family protein; Region: TIGR03086 478433001567 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 478433001568 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 478433001569 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 478433001570 PE family; Region: PE; pfam00934 478433001571 Ub domain fused to Mut7-C; Region: Ub-Mut7C; pfam14451 478433001572 Uncharacterized conserved protein [Function unknown]; Region: COG1656 478433001573 Protein of unknown function DUF82; Region: DUF82; pfam01927 478433001574 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 478433001575 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 478433001576 putative active site [active] 478433001577 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 478433001578 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 478433001579 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 478433001580 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 478433001581 Transcriptional regulators [Transcription]; Region: FadR; COG2186 478433001582 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 478433001583 DNA-binding site [nucleotide binding]; DNA binding site 478433001584 FCD domain; Region: FCD; pfam07729 478433001585 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 478433001586 Permease; Region: Permease; pfam02405 478433001587 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 478433001588 Permease; Region: Permease; pfam02405 478433001589 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 478433001590 mce related protein; Region: MCE; pfam02470 478433001591 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 478433001592 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 478433001593 mce related protein; Region: MCE; pfam02470 478433001594 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 478433001595 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 478433001596 mce related protein; Region: MCE; pfam02470 478433001597 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 478433001598 mce related protein; Region: MCE; pfam02470 478433001599 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 478433001600 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 478433001601 mce related protein; Region: MCE; pfam02470 478433001602 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 478433001603 mce related protein; Region: MCE; pfam02470 478433001604 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 478433001605 oligomeric interface; other site 478433001606 putative active site [active] 478433001607 homodimer interface [polypeptide binding]; other site 478433001608 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 478433001609 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 478433001610 AAA domain; Region: AAA_14; pfam13173 478433001611 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 478433001612 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 478433001613 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 478433001614 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 478433001615 ATP binding site [chemical binding]; other site 478433001616 Mg2+ binding site [ion binding]; other site 478433001617 G-X-G motif; other site 478433001618 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 478433001619 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 478433001620 active site 478433001621 phosphorylation site [posttranslational modification] 478433001622 intermolecular recognition site; other site 478433001623 dimerization interface [polypeptide binding]; other site 478433001624 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 478433001625 DNA binding site [nucleotide binding] 478433001626 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 478433001627 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 478433001628 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 478433001629 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 478433001630 catalytic residues [active] 478433001631 catalytic nucleophile [active] 478433001632 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 478433001633 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 478433001634 Probable transposase; Region: OrfB_IS605; pfam01385 478433001635 Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704 478433001636 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 478433001637 putative active site [active] 478433001638 SEC-C motif; Region: SEC-C; pfam02810 478433001639 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB-like; cd09875 478433001640 putative active site [active] 478433001641 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 478433001642 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 478433001643 nucleotide binding site/active site [active] 478433001644 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 478433001645 galactokinase; Provisional; Region: PRK00555 478433001646 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 478433001647 Protein of unknown function (DUF732); Region: DUF732; pfam05305 478433001648 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4423 478433001649 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 478433001650 putative active site [active] 478433001651 Uncharacterized conserved protein [Function unknown]; Region: COG0398 478433001652 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 478433001653 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 478433001654 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 478433001655 oligomeric interface; other site 478433001656 putative active site [active] 478433001657 homodimer interface [polypeptide binding]; other site 478433001658 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398 478433001659 FIST N domain; Region: FIST; pfam08495 478433001660 FIST C domain; Region: FIST_C; pfam10442 478433001661 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 478433001662 AAA domain; Region: AAA_30; pfam13604 478433001663 Family description; Region: UvrD_C_2; pfam13538 478433001664 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 478433001665 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 478433001666 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 478433001667 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 478433001668 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 478433001669 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 478433001670 substrate binding site [chemical binding]; other site 478433001671 oxyanion hole (OAH) forming residues; other site 478433001672 trimer interface [polypeptide binding]; other site 478433001673 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 478433001674 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 478433001675 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 478433001676 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 478433001677 active site 478433001678 catalytic site [active] 478433001679 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 478433001680 active site 478433001681 catalytic site [active] 478433001682 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 478433001683 active site 478433001684 catalytic site [active] 478433001685 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 478433001686 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 478433001687 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 478433001688 putative homodimer interface [polypeptide binding]; other site 478433001689 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 478433001690 heterodimer interface [polypeptide binding]; other site 478433001691 homodimer interface [polypeptide binding]; other site 478433001692 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 478433001693 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 478433001694 23S rRNA interface [nucleotide binding]; other site 478433001695 L7/L12 interface [polypeptide binding]; other site 478433001696 putative thiostrepton binding site; other site 478433001697 L25 interface [polypeptide binding]; other site 478433001698 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 478433001699 mRNA/rRNA interface [nucleotide binding]; other site 478433001700 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 478433001701 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478433001702 S-adenosylmethionine binding site [chemical binding]; other site 478433001703 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 478433001704 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 478433001705 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478433001706 S-adenosylmethionine binding site [chemical binding]; other site 478433001707 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 478433001708 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 478433001709 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478433001710 S-adenosylmethionine binding site [chemical binding]; other site 478433001711 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 478433001712 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 478433001713 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478433001714 S-adenosylmethionine binding site [chemical binding]; other site 478433001715 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 478433001716 TAP-like protein; Region: Abhydrolase_4; pfam08386 478433001717 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 478433001718 ABC1 family; Region: ABC1; cl17513 478433001719 N-terminal catalytic domain of class II alpha-mannosidases and similar proteins; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_like; cd10786 478433001720 active site 478433001721 catalytic site [active] 478433001722 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 478433001723 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 478433001724 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 478433001725 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 478433001726 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 478433001727 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 478433001728 23S rRNA interface [nucleotide binding]; other site 478433001729 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 478433001730 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 478433001731 core dimer interface [polypeptide binding]; other site 478433001732 peripheral dimer interface [polypeptide binding]; other site 478433001733 L10 interface [polypeptide binding]; other site 478433001734 L11 interface [polypeptide binding]; other site 478433001735 putative EF-Tu interaction site [polypeptide binding]; other site 478433001736 putative EF-G interaction site [polypeptide binding]; other site 478433001737 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 478433001738 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478433001739 WHG domain; Region: WHG; pfam13305 478433001740 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 478433001741 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 478433001742 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 478433001743 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 478433001744 Walker A/P-loop; other site 478433001745 ATP binding site [chemical binding]; other site 478433001746 Q-loop/lid; other site 478433001747 ABC transporter signature motif; other site 478433001748 Walker B; other site 478433001749 D-loop; other site 478433001750 H-loop/switch region; other site 478433001751 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 478433001752 putative active site [active] 478433001753 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 478433001754 Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266 478433001755 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 478433001756 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG1848 478433001757 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 478433001758 Sulfatase; Region: Sulfatase; pfam00884 478433001759 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 478433001760 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 478433001761 putative active site [active] 478433001762 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 478433001763 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 478433001764 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 478433001765 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 478433001766 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 478433001767 RPB10 interaction site [polypeptide binding]; other site 478433001768 RPB1 interaction site [polypeptide binding]; other site 478433001769 RPB11 interaction site [polypeptide binding]; other site 478433001770 RPB3 interaction site [polypeptide binding]; other site 478433001771 RPB12 interaction site [polypeptide binding]; other site 478433001772 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 478433001773 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 478433001774 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 478433001775 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 478433001776 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 478433001777 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 478433001778 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 478433001779 G-loop; other site 478433001780 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 478433001781 DNA binding site [nucleotide binding] 478433001782 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 478433001783 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; pfam04734 478433001784 endonuclease IV; Provisional; Region: PRK01060 478433001785 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 478433001786 Metal-binding active site; metal-binding site 478433001787 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 478433001788 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 478433001789 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 478433001790 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 478433001791 active site 478433001792 enoyl-CoA hydratase; Provisional; Region: PRK12478 478433001793 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 478433001794 substrate binding site [chemical binding]; other site 478433001795 oxyanion hole (OAH) forming residues; other site 478433001796 trimer interface [polypeptide binding]; other site 478433001797 Phenylacetic acid-responsive transcriptional repressor [Transcription]; Region: PaaX; COG3327 478433001798 PaaX-like protein; Region: PaaX; pfam07848 478433001799 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 478433001800 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 478433001801 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 478433001802 substrate binding site [chemical binding]; other site 478433001803 oxyanion hole (OAH) forming residues; other site 478433001804 trimer interface [polypeptide binding]; other site 478433001805 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 478433001806 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 478433001807 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 478433001808 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 478433001809 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 478433001810 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478433001811 WHG domain; Region: WHG; pfam13305 478433001812 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 478433001813 S17 interaction site [polypeptide binding]; other site 478433001814 S8 interaction site; other site 478433001815 16S rRNA interaction site [nucleotide binding]; other site 478433001816 streptomycin interaction site [chemical binding]; other site 478433001817 23S rRNA interaction site [nucleotide binding]; other site 478433001818 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 478433001819 30S ribosomal protein S7; Validated; Region: PRK05302 478433001820 elongation factor G; Reviewed; Region: PRK00007 478433001821 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 478433001822 G1 box; other site 478433001823 putative GEF interaction site [polypeptide binding]; other site 478433001824 GTP/Mg2+ binding site [chemical binding]; other site 478433001825 Switch I region; other site 478433001826 G2 box; other site 478433001827 G3 box; other site 478433001828 Switch II region; other site 478433001829 G4 box; other site 478433001830 G5 box; other site 478433001831 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 478433001832 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 478433001833 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 478433001834 elongation factor Tu; Reviewed; Region: PRK00049 478433001835 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 478433001836 G1 box; other site 478433001837 GEF interaction site [polypeptide binding]; other site 478433001838 GTP/Mg2+ binding site [chemical binding]; other site 478433001839 Switch I region; other site 478433001840 G2 box; other site 478433001841 G3 box; other site 478433001842 Switch II region; other site 478433001843 G4 box; other site 478433001844 G5 box; other site 478433001845 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 478433001846 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 478433001847 Antibiotic Binding Site [chemical binding]; other site 478433001848 Short C-terminal domain; Region: SHOCT; pfam09851 478433001849 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 478433001850 classical (c) SDRs; Region: SDR_c; cd05233 478433001851 NAD(P) binding site [chemical binding]; other site 478433001852 active site 478433001853 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 478433001854 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 478433001855 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4427 478433001856 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 478433001857 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478433001858 putative mycofactocin binding protein MftB; Region: mycofact_MftB; TIGR03967 478433001859 mycofactocin radical SAM maturase; Region: mycofact_rSAM; TIGR03962 478433001860 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 478433001861 FeS/SAM binding site; other site 478433001862 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 478433001863 heme/flavin dehydrogenase, mycofactocin system; Region: actino_HemFlav; TIGR03966 478433001864 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 478433001865 phosphate binding site [ion binding]; other site 478433001866 mycofactocin system creatininase family protein; Region: mycofact_creat; TIGR03964 478433001867 mycofactocin system glycosyltransferase; Region: mycofact_glyco; TIGR03965 478433001868 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 478433001869 Probable Catalytic site; other site 478433001870 metal-binding site 478433001871 dehydrogenase, Rv0697 family; Region: Rv0697; TIGR03970 478433001872 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 478433001873 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 478433001874 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 478433001875 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 478433001876 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 478433001877 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 478433001878 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 478433001879 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 478433001880 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 478433001881 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 478433001882 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 478433001883 putative translocon binding site; other site 478433001884 protein-rRNA interface [nucleotide binding]; other site 478433001885 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 478433001886 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 478433001887 G-X-X-G motif; other site 478433001888 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 478433001889 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 478433001890 23S rRNA interface [nucleotide binding]; other site 478433001891 5S rRNA interface [nucleotide binding]; other site 478433001892 putative antibiotic binding site [chemical binding]; other site 478433001893 L25 interface [polypeptide binding]; other site 478433001894 L27 interface [polypeptide binding]; other site 478433001895 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 478433001896 putative translocon interaction site; other site 478433001897 23S rRNA interface [nucleotide binding]; other site 478433001898 signal recognition particle (SRP54) interaction site; other site 478433001899 L23 interface [polypeptide binding]; other site 478433001900 trigger factor interaction site; other site 478433001901 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 478433001902 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 478433001903 Sulfatase; Region: Sulfatase; pfam00884 478433001904 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl17353 478433001905 Uncharacterized conserved protein [Function unknown]; Region: COG1262 478433001906 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 478433001907 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 478433001908 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 478433001909 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 478433001910 RNA binding site [nucleotide binding]; other site 478433001911 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 478433001912 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 478433001913 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 478433001914 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 478433001915 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 478433001916 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 478433001917 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 478433001918 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 478433001919 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 478433001920 5S rRNA interface [nucleotide binding]; other site 478433001921 23S rRNA interface [nucleotide binding]; other site 478433001922 L5 interface [polypeptide binding]; other site 478433001923 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 478433001924 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 478433001925 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 478433001926 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 478433001927 23S rRNA binding site [nucleotide binding]; other site 478433001928 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 478433001929 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 478433001930 tandem repeat interface [polypeptide binding]; other site 478433001931 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 478433001932 oligomer interface [polypeptide binding]; other site 478433001933 active site residues [active] 478433001934 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 478433001935 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 478433001936 tandem repeat interface [polypeptide binding]; other site 478433001937 oligomer interface [polypeptide binding]; other site 478433001938 active site residues [active] 478433001939 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 478433001940 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 478433001941 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 478433001942 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 478433001943 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 478433001944 intersubunit interface [polypeptide binding]; other site 478433001945 active site 478433001946 Zn2+ binding site [ion binding]; other site 478433001947 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 478433001948 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 478433001949 NAD binding site [chemical binding]; other site 478433001950 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 478433001951 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 478433001952 nucleotide binding site [chemical binding]; other site 478433001953 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 478433001954 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 478433001955 Coenzyme A binding pocket [chemical binding]; other site 478433001956 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 478433001957 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 478433001958 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 478433001959 SecY translocase; Region: SecY; pfam00344 478433001960 adenylate kinase; Reviewed; Region: adk; PRK00279 478433001961 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 478433001962 AMP-binding site [chemical binding]; other site 478433001963 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 478433001964 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 478433001965 active site 478433001966 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 478433001967 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 478433001968 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 478433001969 DNA binding residues [nucleotide binding] 478433001970 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 478433001971 Putative zinc-finger; Region: zf-HC2; pfam13490 478433001972 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 478433001973 MarR family; Region: MarR; pfam01047 478433001974 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 478433001975 TIGR03086 family protein; Region: TIGR03086 478433001976 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 478433001977 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 478433001978 Transposase; Region: DDE_Tnp_ISL3; pfam01610 478433001979 Helix-turn-helix domain; Region: HTH_17; pfam12728 478433001980 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 478433001981 PE family; Region: PE; pfam00934 478433001982 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 478433001983 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 478433001984 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 478433001985 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 478433001986 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 478433001987 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 478433001988 active site 478433001989 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 478433001990 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 478433001991 tetrameric interface [polypeptide binding]; other site 478433001992 NAD binding site [chemical binding]; other site 478433001993 catalytic residues [active] 478433001994 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 478433001995 catalytic core [active] 478433001996 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478433001997 PPE family; Region: PPE; pfam00823 478433001998 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478433001999 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478433002000 Helix-turn-helix domain; Region: HTH_28; pfam13518 478433002001 Winged helix-turn helix; Region: HTH_29; pfam13551 478433002002 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 478433002003 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 478433002004 active site 478433002005 phosphorylation site [posttranslational modification] 478433002006 intermolecular recognition site; other site 478433002007 dimerization interface [polypeptide binding]; other site 478433002008 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 478433002009 DNA binding site [nucleotide binding] 478433002010 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 478433002011 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 478433002012 dimerization interface [polypeptide binding]; other site 478433002013 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 478433002014 dimer interface [polypeptide binding]; other site 478433002015 phosphorylation site [posttranslational modification] 478433002016 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 478433002017 ATP binding site [chemical binding]; other site 478433002018 Mg2+ binding site [ion binding]; other site 478433002019 G-X-G motif; other site 478433002020 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 478433002021 nucleotide binding site/active site [active] 478433002022 HIT family signature motif; other site 478433002023 catalytic residue [active] 478433002024 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 478433002025 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 478433002026 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 478433002027 NAD binding site [chemical binding]; other site 478433002028 catalytic Zn binding site [ion binding]; other site 478433002029 substrate binding site [chemical binding]; other site 478433002030 structural Zn binding site [ion binding]; other site 478433002031 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 478433002032 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 478433002033 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 478433002034 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 478433002035 Cytochrome P450; Region: p450; cl12078 478433002036 short chain dehydrogenase; Provisional; Region: PRK07775 478433002037 classical (c) SDRs; Region: SDR_c; cd05233 478433002038 NAD(P) binding site [chemical binding]; other site 478433002039 active site 478433002040 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 478433002041 Cytochrome P450; Region: p450; cl12078 478433002042 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 478433002043 Cytochrome P450; Region: p450; cl12078 478433002044 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 478433002045 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 478433002046 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 478433002047 NAD binding site [chemical binding]; other site 478433002048 catalytic residues [active] 478433002049 short chain dehydrogenase; Provisional; Region: PRK07774 478433002050 classical (c) SDRs; Region: SDR_c; cd05233 478433002051 NAD(P) binding site [chemical binding]; other site 478433002052 active site 478433002053 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 478433002054 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 478433002055 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 478433002056 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 478433002057 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 478433002058 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 478433002059 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 478433002060 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 478433002061 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 478433002062 Predicted esterase [General function prediction only]; Region: COG0627 478433002063 S-formylglutathione hydrolase; Region: PLN02442 478433002064 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 478433002065 Predicted nuclease (RNAse H fold) [General function prediction only]; Region: COG4328 478433002066 Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302 478433002067 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 478433002068 tetramer interface [polypeptide binding]; other site 478433002069 active site 478433002070 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 478433002071 Cytochrome P450; Region: p450; cl12078 478433002072 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 478433002073 ATP binding site [chemical binding]; other site 478433002074 active site 478433002075 substrate binding site [chemical binding]; other site 478433002076 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 478433002077 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 478433002078 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 478433002079 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 478433002080 putative substrate translocation pore; other site 478433002081 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 478433002082 Predicted deacetylase [General function prediction only]; Region: COG3233 478433002083 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374 478433002084 putative active site [active] 478433002085 putative Zn binding site [ion binding]; other site 478433002086 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 478433002087 FAD binding domain; Region: FAD_binding_2; pfam00890 478433002088 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 478433002089 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 478433002090 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 478433002091 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 478433002092 putative active site [active] 478433002093 catalytic triad [active] 478433002094 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 478433002095 Transglutaminase/protease-like homologues; Region: TGc; smart00460 478433002096 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 478433002097 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 478433002098 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 478433002099 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 478433002100 DNA-binding site [nucleotide binding]; DNA binding site 478433002101 UTRA domain; Region: UTRA; pfam07702 478433002102 Uncharacterized conserved protein [Function unknown]; Region: COG1359 478433002103 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 478433002104 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 478433002105 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 478433002106 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 478433002107 Transposase; Region: DEDD_Tnp_IS110; pfam01548 478433002108 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 478433002109 Transposase; Region: DEDD_Tnp_IS110; pfam01548 478433002110 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 478433002111 Uncharacterized protein, linocin/CFP29 homolog [Function unknown]; Region: COG1659 478433002112 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 478433002113 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 478433002114 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 478433002115 active site 478433002116 metal binding site [ion binding]; metal-binding site 478433002117 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 478433002118 active site 478433002119 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 478433002120 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 478433002121 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 478433002122 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 478433002123 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 478433002124 dimerization interface [polypeptide binding]; other site 478433002125 ATP binding site [chemical binding]; other site 478433002126 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 478433002127 dimerization interface [polypeptide binding]; other site 478433002128 ATP binding site [chemical binding]; other site 478433002129 CAAX protease self-immunity; Region: Abi; pfam02517 478433002130 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 478433002131 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 478433002132 active site 478433002133 metal binding site [ion binding]; metal-binding site 478433002134 hexamer interface [polypeptide binding]; other site 478433002135 Protein of unknown function (DUF3184); Region: DUF3184; pfam11380 478433002136 amidophosphoribosyltransferase; Provisional; Region: PRK07847 478433002137 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 478433002138 active site 478433002139 tetramer interface [polypeptide binding]; other site 478433002140 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 478433002141 active site 478433002142 phosphoribosylaminoimidazole synthetase; Region: purM; TIGR00878 478433002143 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 478433002144 dimerization interface [polypeptide binding]; other site 478433002145 putative ATP binding site [chemical binding]; other site 478433002146 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 478433002147 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 478433002148 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 478433002149 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 478433002150 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 478433002151 pyridoxal 5'-phosphate binding site [chemical binding]; other site 478433002152 catalytic residue [active] 478433002153 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 478433002154 heme-binding site [chemical binding]; other site 478433002155 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 478433002156 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 478433002157 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 478433002158 active site residue [active] 478433002159 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 478433002160 active site residue [active] 478433002161 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 478433002162 catalytic residues [active] 478433002163 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 478433002164 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 478433002165 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 478433002166 DNA binding site [nucleotide binding] 478433002167 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 478433002168 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 478433002169 Coenzyme A binding pocket [chemical binding]; other site 478433002170 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 478433002171 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 478433002172 Walker A/P-loop; other site 478433002173 ATP binding site [chemical binding]; other site 478433002174 Q-loop/lid; other site 478433002175 ABC transporter signature motif; other site 478433002176 Walker B; other site 478433002177 D-loop; other site 478433002178 H-loop/switch region; other site 478433002179 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 478433002180 PhoU domain; Region: PhoU; pfam01895 478433002181 PhoU domain; Region: PhoU; pfam01895 478433002182 cell envelope-related function transcriptional attenuator common domain; Region: lytR_cpsA_psr; TIGR00350 478433002183 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 478433002184 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 478433002185 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 478433002186 FMN binding site [chemical binding]; other site 478433002187 active site 478433002188 catalytic residues [active] 478433002189 substrate binding site [chemical binding]; other site 478433002190 Fatty acid desaturase; Region: FA_desaturase_2; pfam03405 478433002191 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 478433002192 homodimer interface [polypeptide binding]; other site 478433002193 putative substrate binding pocket [chemical binding]; other site 478433002194 diiron center [ion binding]; other site 478433002195 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 478433002196 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 478433002197 dimerization interface [polypeptide binding]; other site 478433002198 putative DNA binding site [nucleotide binding]; other site 478433002199 putative Zn2+ binding site [ion binding]; other site 478433002200 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 478433002201 dimer interface [polypeptide binding]; other site 478433002202 catalytic motif [active] 478433002203 nucleoside/Zn binding site; other site 478433002204 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 478433002205 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 478433002206 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 478433002207 TIGR04255 family protein; Region: sporadTIGR04255 478433002208 PE family; Region: PE; pfam00934 478433002209 PE family; Region: PE; pfam00934 478433002210 PknH-like extracellular domain; Region: PknH_C; pfam14032 478433002211 putative transposase OrfB; Reviewed; Region: PHA02517 478433002212 HTH-like domain; Region: HTH_21; pfam13276 478433002213 Integrase core domain; Region: rve; pfam00665 478433002214 Integrase core domain; Region: rve_3; pfam13683 478433002215 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 478433002216 Transposase; Region: HTH_Tnp_1; cl17663 478433002217 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 478433002218 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 478433002219 MoaE interaction surface [polypeptide binding]; other site 478433002220 MoeB interaction surface [polypeptide binding]; other site 478433002221 thiocarboxylated glycine; other site 478433002222 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 478433002223 trimer interface [polypeptide binding]; other site 478433002224 dimer interface [polypeptide binding]; other site 478433002225 putative active site [active] 478433002226 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 478433002227 aromatic arch; other site 478433002228 DCoH dimer interaction site [polypeptide binding]; other site 478433002229 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 478433002230 DCoH tetramer interaction site [polypeptide binding]; other site 478433002231 substrate binding site [chemical binding]; other site 478433002232 Molybdenum cofactor biosynthesis enzyme [Coenzyme metabolism]; Region: MoaA; COG2896 478433002233 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 478433002234 FeS/SAM binding site; other site 478433002235 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 478433002236 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 478433002237 FAD binding domain; Region: FAD_binding_4; pfam01565 478433002238 ferredoxin-NADP+ reductase; Region: PLN02852 478433002239 peptide chain release factor 2; Validated; Region: prfB; PRK00578 478433002240 This domain is found in peptide chain release factors; Region: PCRF; smart00937 478433002241 RF-1 domain; Region: RF-1; pfam00472 478433002242 Mechanosensitive ion channel; Region: MS_channel; pfam00924 478433002243 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 478433002244 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 478433002245 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 478433002246 Walker A/P-loop; other site 478433002247 ATP binding site [chemical binding]; other site 478433002248 Q-loop/lid; other site 478433002249 ABC transporter signature motif; other site 478433002250 Walker B; other site 478433002251 D-loop; other site 478433002252 H-loop/switch region; other site 478433002253 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 478433002254 FtsX-like permease family; Region: FtsX; pfam02687 478433002255 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 478433002256 SmpB-tmRNA interface; other site 478433002257 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 478433002258 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 478433002259 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 478433002260 PemK-like protein; Region: PemK; pfam02452 478433002261 PE family; Region: PE; pfam00934 478433002262 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 478433002263 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 478433002264 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 478433002265 Predicted transcriptional regulators [Transcription]; Region: COG1733 478433002266 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 478433002267 dimerization interface [polypeptide binding]; other site 478433002268 putative DNA binding site [nucleotide binding]; other site 478433002269 putative Zn2+ binding site [ion binding]; other site 478433002270 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 478433002271 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 478433002272 active site 478433002273 probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841 478433002274 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 478433002275 Protein of unknown function (DUF808); Region: DUF808; cl01002 478433002276 Patatin-like phospholipase; Region: Patatin; pfam01734 478433002277 SPFH domain / Band 7 family; Region: Band_7; pfam01145 478433002278 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 478433002279 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 478433002280 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 478433002281 acyl-activating enzyme (AAE) consensus motif; other site 478433002282 AMP binding site [chemical binding]; other site 478433002283 active site 478433002284 CoA binding site [chemical binding]; other site 478433002285 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 478433002286 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 478433002287 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 478433002288 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 478433002289 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 478433002290 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 478433002291 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 478433002292 NAD binding site [chemical binding]; other site 478433002293 catalytic Zn binding site [ion binding]; other site 478433002294 substrate binding site [chemical binding]; other site 478433002295 structural Zn binding site [ion binding]; other site 478433002296 short chain dehydrogenase; Provisional; Region: PRK07832 478433002297 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 478433002298 NAD(P) binding site [chemical binding]; other site 478433002299 active site 478433002300 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 478433002301 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 478433002302 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 478433002303 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 478433002304 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 478433002305 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 478433002306 Nucleotidyl transferase of unknown function (DUF2204); Region: DUF2204; pfam09970 478433002307 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 478433002308 Catalytic domain of Protein Kinases; Region: PKc; cd00180 478433002309 active site 478433002310 ATP binding site [chemical binding]; other site 478433002311 substrate binding site [chemical binding]; other site 478433002312 activation loop (A-loop); other site 478433002313 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 478433002314 AAA ATPase domain; Region: AAA_16; pfam13191 478433002315 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 478433002316 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 478433002317 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 478433002318 Sulfatase; Region: Sulfatase; pfam00884 478433002319 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 478433002320 putative hydrophobic ligand binding site [chemical binding]; other site 478433002321 protein interface [polypeptide binding]; other site 478433002322 gate; other site 478433002323 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 478433002324 Domain of unknown function (DUF222); Region: DUF222; pfam02720 478433002325 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 478433002326 active site 478433002327 Uncharacterized conserved protein [Function unknown]; Region: COG3189 478433002328 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 478433002329 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 478433002330 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 478433002331 Uncharacterized ACR, COG1993; Region: DUF190; pfam02641 478433002332 camphor resistance protein CrcB; Provisional; Region: PRK14228 478433002333 camphor resistance protein CrcB; Provisional; Region: PRK14216 478433002334 phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132 478433002335 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 478433002336 active site 478433002337 substrate binding site [chemical binding]; other site 478433002338 metal binding site [ion binding]; metal-binding site 478433002339 Protein of unknown function (DUF732); Region: DUF732; pfam05305 478433002340 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 478433002341 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478433002342 Small Multidrug Resistance protein; Region: Multi_Drug_Res; pfam00893 478433002343 Predicted membrane protein [Function unknown]; Region: COG2259 478433002344 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 478433002345 Carbon starvation protein CstA; Region: CstA; pfam02554 478433002346 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 478433002347 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180 478433002348 Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901 478433002349 active site 478433002350 DNA binding site [nucleotide binding] 478433002351 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 478433002352 DNA binding site [nucleotide binding] 478433002353 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 478433002354 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 478433002355 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 478433002356 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 478433002357 active site 478433002358 Transcriptional regulators [Transcription]; Region: FadR; COG2186 478433002359 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 478433002360 DNA-binding site [nucleotide binding]; DNA binding site 478433002361 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 478433002362 Transcriptional regulators [Transcription]; Region: FadR; COG2186 478433002363 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 478433002364 DNA-binding site [nucleotide binding]; DNA binding site 478433002365 FCD domain; Region: FCD; pfam07729 478433002366 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 478433002367 Cytochrome P450; Region: p450; cl12078 478433002368 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 478433002369 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478433002370 short chain dehydrogenase; Provisional; Region: PRK07832 478433002371 classical (c) SDRs; Region: SDR_c; cd05233 478433002372 NAD(P) binding site [chemical binding]; other site 478433002373 active site 478433002374 DNA polymerase IV; Validated; Region: PRK03352 478433002375 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 478433002376 active site 478433002377 DNA binding site [nucleotide binding] 478433002378 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 478433002379 Predicted flavoprotein [General function prediction only]; Region: COG0431 478433002380 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 478433002381 catalytic residues [active] 478433002382 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 478433002383 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 478433002384 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 478433002385 Class I ribonucleotide reductase; Region: RNR_I; cd01679 478433002386 active site 478433002387 dimer interface [polypeptide binding]; other site 478433002388 catalytic residues [active] 478433002389 effector binding site; other site 478433002390 R2 peptide binding site; other site 478433002391 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 478433002392 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478433002393 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 478433002394 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 478433002395 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 478433002396 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 478433002397 dimer interface [polypeptide binding]; other site 478433002398 putative radical transfer pathway; other site 478433002399 diiron center [ion binding]; other site 478433002400 tyrosyl radical; other site 478433002401 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 478433002402 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 478433002403 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 478433002404 putative NAD(P) binding site [chemical binding]; other site 478433002405 putative substrate binding site [chemical binding]; other site 478433002406 catalytic Zn binding site [ion binding]; other site 478433002407 structural Zn binding site [ion binding]; other site 478433002408 dimer interface [polypeptide binding]; other site 478433002409 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 478433002410 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 478433002411 siderophore binding site; other site 478433002412 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 478433002413 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 478433002414 D-pathway; other site 478433002415 Putative ubiquinol binding site [chemical binding]; other site 478433002416 Low-spin heme (heme b) binding site [chemical binding]; other site 478433002417 Putative water exit pathway; other site 478433002418 Binuclear center (heme o3/CuB) [ion binding]; other site 478433002419 K-pathway; other site 478433002420 Putative proton exit pathway; other site 478433002421 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 478433002422 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 478433002423 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 478433002424 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 478433002425 motif II; other site 478433002426 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119 478433002427 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 478433002428 Walker A/P-loop; other site 478433002429 ATP binding site [chemical binding]; other site 478433002430 Q-loop/lid; other site 478433002431 ABC transporter signature motif; other site 478433002432 Walker B; other site 478433002433 D-loop; other site 478433002434 H-loop/switch region; other site 478433002435 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 478433002436 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 478433002437 substrate binding site [chemical binding]; other site 478433002438 oxyanion hole (OAH) forming residues; other site 478433002439 trimer interface [polypeptide binding]; other site 478433002440 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478433002441 S-adenosylmethionine binding site [chemical binding]; other site 478433002442 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 478433002443 FOG: WD40-like repeat [Function unknown]; Region: COG1520 478433002444 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 478433002445 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 478433002446 trimer interface [polypeptide binding]; other site 478433002447 active site 478433002448 substrate binding site [chemical binding]; other site 478433002449 CoA binding site [chemical binding]; other site 478433002450 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 478433002451 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 478433002452 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 478433002453 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 478433002454 Uncharacterized conserved protein [Function unknown]; Region: COG1543 478433002455 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 478433002456 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 478433002457 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478433002458 S-adenosylmethionine binding site [chemical binding]; other site 478433002459 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 478433002460 Ligand binding site [chemical binding]; other site 478433002461 Electron transfer flavoprotein domain; Region: ETF; pfam01012 478433002462 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 478433002463 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 478433002464 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 478433002465 Putative hemolysin [General function prediction only]; Region: COG3176 478433002466 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 478433002467 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 478433002468 putative acyl-acceptor binding pocket; other site 478433002469 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 478433002470 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 478433002471 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 478433002472 catalytic residue [active] 478433002473 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 478433002474 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 478433002475 Ligand Binding Site [chemical binding]; other site 478433002476 Transposase, Mutator family; Region: Transposase_mut; pfam00872 478433002477 MULE transposase domain; Region: MULE; pfam10551 478433002478 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478433002479 PPE family; Region: PPE; pfam00823 478433002480 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 478433002481 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478433002482 PPE family; Region: PPE; pfam00823 478433002483 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 478433002484 PknH-like extracellular domain; Region: PknH_C; pfam14032 478433002485 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310 478433002486 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 478433002487 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 478433002488 nucleotide binding pocket [chemical binding]; other site 478433002489 K-X-D-G motif; other site 478433002490 catalytic site [active] 478433002491 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 478433002492 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 478433002493 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 478433002494 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 478433002495 Dimer interface [polypeptide binding]; other site 478433002496 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 478433002497 aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, C subunit; Region: gatC; TIGR00135 478433002498 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 478433002499 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 478433002500 6-phosphofructokinase; Provisional; Region: PRK03202 478433002501 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 478433002502 active site 478433002503 ADP/pyrophosphate binding site [chemical binding]; other site 478433002504 dimerization interface [polypeptide binding]; other site 478433002505 allosteric effector site; other site 478433002506 fructose-1,6-bisphosphate binding site; other site 478433002507 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 478433002508 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 478433002509 GatB domain; Region: GatB_Yqey; smart00845 478433002510 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 478433002511 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 478433002512 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 478433002513 Predicted membrane protein [Function unknown]; Region: COG2259 478433002514 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 478433002515 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 478433002516 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 478433002517 PYR/PP interface [polypeptide binding]; other site 478433002518 dimer interface [polypeptide binding]; other site 478433002519 TPP binding site [chemical binding]; other site 478433002520 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 478433002521 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 478433002522 TPP-binding site [chemical binding]; other site 478433002523 dimer interface [polypeptide binding]; other site 478433002524 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 478433002525 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 478433002526 putative valine binding site [chemical binding]; other site 478433002527 dimer interface [polypeptide binding]; other site 478433002528 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 478433002529 ketol-acid reductoisomerase; Provisional; Region: PRK05479 478433002530 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 478433002531 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 478433002532 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 478433002533 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 478433002534 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 478433002535 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 478433002536 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 478433002537 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 478433002538 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 478433002539 ligand binding site [chemical binding]; other site 478433002540 NAD binding site [chemical binding]; other site 478433002541 dimerization interface [polypeptide binding]; other site 478433002542 catalytic site [active] 478433002543 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 478433002544 putative L-serine binding site [chemical binding]; other site 478433002545 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 478433002546 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 478433002547 Major Facilitator Superfamily; Region: MFS_1; pfam07690 478433002548 putative substrate translocation pore; other site 478433002549 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 478433002550 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 478433002551 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 478433002552 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 478433002553 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 478433002554 active site 478433002555 HIGH motif; other site 478433002556 nucleotide binding site [chemical binding]; other site 478433002557 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 478433002558 active site 478433002559 KMSKS motif; other site 478433002560 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 478433002561 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 478433002562 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478433002563 S-adenosylmethionine binding site [chemical binding]; other site 478433002564 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 478433002565 Transcriptional regulator [Transcription]; Region: IclR; COG1414 478433002566 Bacterial transcriptional regulator; Region: IclR; pfam01614 478433002567 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 478433002568 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 478433002569 substrate binding site [chemical binding]; other site 478433002570 ligand binding site [chemical binding]; other site 478433002571 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 478433002572 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 478433002573 substrate binding site [chemical binding]; other site 478433002574 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 478433002575 IHF - DNA interface [nucleotide binding]; other site 478433002576 IHF dimer interface [polypeptide binding]; other site 478433002577 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 478433002578 active site 478433002579 Ap6A binding site [chemical binding]; other site 478433002580 nudix motif; other site 478433002581 metal binding site [ion binding]; metal-binding site 478433002582 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 478433002583 catalytic core [active] 478433002584 polyphosphate kinase; Provisional; Region: PRK05443 478433002585 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 478433002586 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 478433002587 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 478433002588 putative domain interface [polypeptide binding]; other site 478433002589 putative active site [active] 478433002590 catalytic site [active] 478433002591 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 478433002592 putative domain interface [polypeptide binding]; other site 478433002593 putative active site [active] 478433002594 catalytic site [active] 478433002595 Predicted nucleotidyltransferase, CobY/MobA/RfbA family [General function prediction only]; Region: COG1920 478433002596 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 478433002597 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 478433002598 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 478433002599 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 478433002600 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 478433002601 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 478433002602 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 478433002603 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 478433002604 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 478433002605 catalytic residues [active] 478433002606 catalytic nucleophile [active] 478433002607 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 478433002608 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 478433002609 Probable transposase; Region: OrfB_IS605; pfam01385 478433002610 thiamine monophosphate kinase; Provisional; Region: PRK05731 478433002611 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 478433002612 ATP binding site [chemical binding]; other site 478433002613 dimerization interface [polypeptide binding]; other site 478433002614 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 478433002615 ligand binding site [chemical binding]; other site 478433002616 active site 478433002617 UGI interface [polypeptide binding]; other site 478433002618 catalytic site [active] 478433002619 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 478433002620 DAK2 domain; Region: Dak2; cl03685 478433002621 DAK2 domain; Region: Dak2; cl03685 478433002622 Dihydroxyacetone kinase family; Region: Dak1_2; pfam13684 478433002623 RecG-like helicase [DNA replication, recombination, and repair / Transcription]; Region: RecG; COG1200 478433002624 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 478433002625 generic binding surface II; other site 478433002626 ssDNA binding site; other site 478433002627 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 478433002628 ATP binding site [chemical binding]; other site 478433002629 putative Mg++ binding site [ion binding]; other site 478433002630 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 478433002631 nucleotide binding region [chemical binding]; other site 478433002632 ATP-binding site [chemical binding]; other site 478433002633 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 478433002634 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 478433002635 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 478433002636 active site 478433002637 catalytic tetrad [active] 478433002638 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 478433002639 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 478433002640 substrate binding pocket [chemical binding]; other site 478433002641 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 478433002642 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 478433002643 catalytic residues [active] 478433002644 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 478433002645 putative active site [active] 478433002646 redox center [active] 478433002647 pyruvate carboxylase; Reviewed; Region: PRK12999 478433002648 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 478433002649 ATP-grasp domain; Region: ATP-grasp_4; cl17255 478433002650 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 478433002651 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 478433002652 active site 478433002653 catalytic residues [active] 478433002654 metal binding site [ion binding]; metal-binding site 478433002655 homodimer binding site [polypeptide binding]; other site 478433002656 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 478433002657 carboxyltransferase (CT) interaction site; other site 478433002658 biotinylation site [posttranslational modification]; other site 478433002659 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 478433002660 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478433002661 S-adenosylmethionine binding site [chemical binding]; other site 478433002662 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 478433002663 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 478433002664 active site 478433002665 (T/H)XGH motif; other site 478433002666 formyltetrahydrofolate deformylase; Region: PurU; TIGR00655 478433002667 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 478433002668 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 478433002669 putative active site [active] 478433002670 putative substrate binding site [chemical binding]; other site 478433002671 putative cosubstrate binding site; other site 478433002672 catalytic site [active] 478433002673 Predicted permease; Region: DUF318; pfam03773 478433002674 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 478433002675 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 478433002676 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 478433002677 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 478433002678 Cephalosporin hydroxylase [Defense mechanisms]; Region: CmcI; COG3510 478433002679 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 478433002680 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 478433002681 active site 478433002682 TDP-binding site; other site 478433002683 acceptor substrate-binding pocket; other site 478433002684 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 478433002685 metal-binding site 478433002686 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 478433002687 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 478433002688 Methyltransferase domain; Region: Methyltransf_23; pfam13489 478433002689 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478433002690 S-adenosylmethionine binding site [chemical binding]; other site 478433002691 Uncharacterized conserved protein [Function unknown]; Region: COG3268 478433002692 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478433002693 S-adenosylmethionine binding site [chemical binding]; other site 478433002694 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 478433002695 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 478433002696 acyl-CoA synthetase; Validated; Region: PRK05850 478433002697 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 478433002698 acyl-activating enzyme (AAE) consensus motif; other site 478433002699 active site 478433002700 4-hydroxybenzoate synthetase (chorismate lyase) [Coenzyme metabolism]; Region: UbiC; COG3161 478433002701 acyl-CoA synthetase; Validated; Region: PRK06060 478433002702 Benzoate CoA ligase (BCL) and similar adenylate forming enzymes; Region: BCL_like; cd05919 478433002703 dimer interface [polypeptide binding]; other site 478433002704 acyl-activating enzyme (AAE) consensus motif; other site 478433002705 putative active site [active] 478433002706 putative AMP binding site [chemical binding]; other site 478433002707 putative CoA binding site [chemical binding]; other site 478433002708 chemical substrate binding site [chemical binding]; other site 478433002709 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 478433002710 Erythronolide synthase docking; Region: Docking; pfam08990 478433002711 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 478433002712 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 478433002713 active site 478433002714 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 478433002715 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 478433002716 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 478433002717 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 478433002718 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 478433002719 Enoylreductase; Region: PKS_ER; smart00829 478433002720 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 478433002721 NAD(P) binding site [chemical binding]; other site 478433002722 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 478433002723 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 478433002724 putative NADP binding site [chemical binding]; other site 478433002725 active site 478433002726 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 478433002727 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 478433002728 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 478433002729 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 478433002730 ATP binding site [chemical binding]; other site 478433002731 Walker A motif; other site 478433002732 Walker B motif; other site 478433002733 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 478433002734 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 478433002735 Integrase core domain; Region: rve; pfam00665 478433002736 MMPL family; Region: MMPL; pfam03176 478433002737 acyl-CoA synthetase; Validated; Region: PRK05850 478433002738 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 478433002739 acyl-activating enzyme (AAE) consensus motif; other site 478433002740 active site 478433002741 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 478433002742 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 478433002743 active site 478433002744 Acyl transferase domain; Region: Acyl_transf_1; pfam00698 478433002745 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 478433002746 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 478433002747 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 478433002748 Enoylreductase; Region: PKS_ER; smart00829 478433002749 NAD(P) binding site [chemical binding]; other site 478433002750 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 478433002751 KR domain; Region: KR; pfam08659 478433002752 putative NADP binding site [chemical binding]; other site 478433002753 active site 478433002754 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 478433002755 acyltransferase PapA5; Provisional; Region: PRK09294 478433002756 ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025 478433002757 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 478433002758 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 478433002759 ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025 478433002760 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 478433002761 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 478433002762 Walker A/P-loop; other site 478433002763 ATP binding site [chemical binding]; other site 478433002764 Q-loop/lid; other site 478433002765 ABC transporter signature motif; other site 478433002766 Walker B; other site 478433002767 D-loop; other site 478433002768 H-loop/switch region; other site 478433002769 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 478433002770 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 478433002771 active site 478433002772 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 478433002773 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 478433002774 Condensation domain; Region: Condensation; pfam00668 478433002775 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 478433002776 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 478433002777 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 478433002778 active site 478433002779 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 478433002780 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 478433002781 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 478433002782 KR domain; Region: KR; pfam08659 478433002783 putative NADP binding site [chemical binding]; other site 478433002784 active site 478433002785 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 478433002786 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 478433002787 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 478433002788 active site 478433002789 Acyl transferase domain; Region: Acyl_transf_1; cl08282 478433002790 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 478433002791 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 478433002792 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 478433002793 Enoylreductase; Region: PKS_ER; smart00829 478433002794 NAD(P) binding site [chemical binding]; other site 478433002795 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 478433002796 KR domain; Region: KR; pfam08659 478433002797 putative NADP binding site [chemical binding]; other site 478433002798 active site 478433002799 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 478433002800 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 478433002801 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 478433002802 active site 478433002803 Acyl transferase domain; Region: Acyl_transf_1; cl08282 478433002804 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 478433002805 KR domain; Region: KR; pfam08659 478433002806 NADP binding site [chemical binding]; other site 478433002807 active site 478433002808 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 478433002809 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 478433002810 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 478433002811 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 478433002812 active site 478433002813 Acyl transferase domain; Region: Acyl_transf_1; pfam00698 478433002814 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 478433002815 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 478433002816 NADP binding site [chemical binding]; other site 478433002817 KR domain; Region: KR; pfam08659 478433002818 active site 478433002819 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 478433002820 acyl-CoA synthetase; Validated; Region: PRK05850 478433002821 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 478433002822 acyl-activating enzyme (AAE) consensus motif; other site 478433002823 active site 478433002824 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 478433002825 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 478433002826 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 478433002827 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 478433002828 ribonuclease III; Reviewed; Region: rnc; PRK00102 478433002829 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 478433002830 dimerization interface [polypeptide binding]; other site 478433002831 active site 478433002832 metal binding site [ion binding]; metal-binding site 478433002833 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 478433002834 dsRNA binding site [nucleotide binding]; other site 478433002835 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 478433002836 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 478433002837 DNA binding site [nucleotide binding] 478433002838 catalytic residue [active] 478433002839 H2TH interface [polypeptide binding]; other site 478433002840 putative catalytic residues [active] 478433002841 turnover-facilitating residue; other site 478433002842 intercalation triad [nucleotide binding]; other site 478433002843 8OG recognition residue [nucleotide binding]; other site 478433002844 putative reading head residues; other site 478433002845 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 478433002846 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 478433002847 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 478433002848 acylphosphatase; Provisional; Region: PRK14422 478433002849 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 478433002850 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 478433002851 Walker A/P-loop; other site 478433002852 ATP binding site [chemical binding]; other site 478433002853 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 478433002854 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 478433002855 ABC transporter signature motif; other site 478433002856 Walker B; other site 478433002857 D-loop; other site 478433002858 H-loop/switch region; other site 478433002859 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 478433002860 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 478433002861 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 478433002862 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 478433002863 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 478433002864 Nitrogen regulatory protein P-II; Region: P-II; smart00938 478433002865 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 478433002866 metal binding triad [ion binding]; metal-binding site 478433002867 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 478433002868 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 478433002869 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 478433002870 ATP binding site [chemical binding]; other site 478433002871 putative Mg++ binding site [ion binding]; other site 478433002872 signal recognition particle protein; Provisional; Region: PRK10867 478433002873 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 478433002874 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 478433002875 P loop; other site 478433002876 GTP binding site [chemical binding]; other site 478433002877 Signal peptide binding domain; Region: SRP_SPB; pfam02978 478433002878 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 478433002879 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 478433002880 active site 478433002881 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 478433002882 Catalytic domain of Protein Kinases; Region: PKc; cd00180 478433002883 active site 478433002884 ATP binding site [chemical binding]; other site 478433002885 substrate binding site [chemical binding]; other site 478433002886 activation loop (A-loop); other site 478433002887 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 478433002888 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 478433002889 active site 478433002890 putative substrate binding pocket [chemical binding]; other site 478433002891 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 478433002892 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 478433002893 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478433002894 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 478433002895 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 478433002896 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 478433002897 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 478433002898 hypothetical protein; Provisional; Region: PRK02821 478433002899 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 478433002900 G-X-X-G motif; other site 478433002901 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 478433002902 RimM N-terminal domain; Region: RimM; pfam01782 478433002903 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 478433002904 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 478433002905 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 478433002906 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 478433002907 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 478433002908 Catalytic site [active] 478433002909 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 478433002910 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 478433002911 RNA/DNA hybrid binding site [nucleotide binding]; other site 478433002912 active site 478433002913 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 478433002914 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 478433002915 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 478433002916 putative molybdopterin cofactor binding site [chemical binding]; other site 478433002917 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 478433002918 putative molybdopterin cofactor binding site; other site 478433002919 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 478433002920 hypothetical protein; Reviewed; Region: PRK12497 478433002921 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 478433002922 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 478433002923 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 478433002924 Walker A motif; other site 478433002925 ATP binding site [chemical binding]; other site 478433002926 Walker B motif; other site 478433002927 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 478433002928 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 478433002929 DNA protecting protein DprA; Region: dprA; TIGR00732 478433002930 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 478433002931 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 478433002932 FAD binding pocket [chemical binding]; other site 478433002933 FAD binding motif [chemical binding]; other site 478433002934 phosphate binding motif [ion binding]; other site 478433002935 NAD binding pocket [chemical binding]; other site 478433002936 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 478433002937 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 478433002938 active site 478433002939 DNA binding site [nucleotide binding] 478433002940 Int/Topo IB signature motif; other site 478433002941 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 478433002942 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 478433002943 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478433002944 PPE family; Region: PPE; pfam00823 478433002945 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 478433002946 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 478433002947 Peptidase family M23; Region: Peptidase_M23; pfam01551 478433002948 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 478433002949 rRNA interaction site [nucleotide binding]; other site 478433002950 S8 interaction site; other site 478433002951 putative laminin-1 binding site; other site 478433002952 elongation factor Ts; Provisional; Region: tsf; PRK09377 478433002953 UBA/TS-N domain; Region: UBA; pfam00627 478433002954 Elongation factor TS; Region: EF_TS; pfam00889 478433002955 Elongation factor TS; Region: EF_TS; pfam00889 478433002956 amidase; Provisional; Region: PRK07869 478433002957 Amidase; Region: Amidase; pfam01425 478433002958 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 478433002959 MarR family; Region: MarR; pfam01047 478433002960 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 478433002961 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 478433002962 catalytic residues [active] 478433002963 catalytic nucleophile [active] 478433002964 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 478433002965 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 478433002966 Probable transposase; Region: OrfB_IS605; pfam01385 478433002967 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 478433002968 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 478433002969 DNA binding site [nucleotide binding] 478433002970 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 478433002971 putative nucleotide binding site [chemical binding]; other site 478433002972 uridine monophosphate binding site [chemical binding]; other site 478433002973 homohexameric interface [polypeptide binding]; other site 478433002974 ribosome recycling factor; Reviewed; Region: frr; PRK00083 478433002975 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 478433002976 hinge region; other site 478433002977 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 478433002978 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 478433002979 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 478433002980 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 478433002981 FeS/SAM binding site; other site 478433002982 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 478433002983 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 478433002984 catalytic residues [active] 478433002985 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 478433002986 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 478433002987 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 478433002988 Fasciclin domain; Region: Fasciclin; pfam02469 478433002989 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 478433002990 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 478433002991 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 478433002992 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 478433002993 catalytic residues [active] 478433002994 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 478433002995 Fasciclin domain; Region: Fasciclin; pfam02469 478433002996 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 478433002997 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 478433002998 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 478433002999 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 478433003000 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 478433003001 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 478433003002 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 478433003003 active site 478433003004 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 478433003005 protein binding site [polypeptide binding]; other site 478433003006 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 478433003007 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 478433003008 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 478433003009 Predicted acetyltransferase [General function prediction only]; Region: COG3393 478433003010 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 478433003011 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 478433003012 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 478433003013 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 478433003014 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 478433003015 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 478433003016 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 478433003017 putative active site [active] 478433003018 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 478433003019 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 478433003020 active site 478433003021 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 478433003022 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 478433003023 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 478433003024 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 478433003025 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 478433003026 catalytic triad [active] 478433003027 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 478433003028 NAD(P)+ dependent aldehyde dehydrogenase family; Region: ALDH; cd07078 478433003029 NAD(P) binding site [chemical binding]; other site 478433003030 catalytic residues [active] 478433003031 short chain dehydrogenase; Provisional; Region: PRK06057 478433003032 classical (c) SDRs; Region: SDR_c; cd05233 478433003033 NAD(P) binding site [chemical binding]; other site 478433003034 active site 478433003035 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 478433003036 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 478433003037 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 478433003038 mycothione reductase; Reviewed; Region: PRK07846 478433003039 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 478433003040 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 478433003041 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 478433003042 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 478433003043 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 478433003044 PE family; Region: PE; pfam00934 478433003045 malate:quinone oxidoreductase; Validated; Region: PRK05257 478433003046 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 478433003047 Predicted acyltransferase [General function prediction only]; Region: ElaA; COG2153 478433003048 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 478433003049 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 478433003050 Walker A motif; other site 478433003051 ATP binding site [chemical binding]; other site 478433003052 Walker B motif; other site 478433003053 arginine finger; other site 478433003054 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 478433003055 metal ion-dependent adhesion site (MIDAS); other site 478433003056 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 478433003057 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 478433003058 homodimer interface [polypeptide binding]; other site 478433003059 Walker A motif; other site 478433003060 ATP binding site [chemical binding]; other site 478433003061 hydroxycobalamin binding site [chemical binding]; other site 478433003062 Walker B motif; other site 478433003063 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 478433003064 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 478433003065 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 478433003066 catalytic triad [active] 478433003067 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 478433003068 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 478433003069 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 478433003070 homodimer interface [polypeptide binding]; other site 478433003071 active site 478433003072 SAM binding site [chemical binding]; other site 478433003073 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 478433003074 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 478433003075 putative substrate translocation pore; other site 478433003076 prolyl-tRNA synthetase; Provisional; Region: PRK09194 478433003077 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 478433003078 dimer interface [polypeptide binding]; other site 478433003079 motif 1; other site 478433003080 active site 478433003081 motif 2; other site 478433003082 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 478433003083 putative deacylase active site [active] 478433003084 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 478433003085 active site 478433003086 motif 3; other site 478433003087 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 478433003088 anticodon binding site; other site 478433003089 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 478433003090 dinuclear metal binding motif [ion binding]; other site 478433003091 ribosome maturation protein RimP; Reviewed; Region: PRK00092 478433003092 Sm and related proteins; Region: Sm_like; cl00259 478433003093 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 478433003094 putative oligomer interface [polypeptide binding]; other site 478433003095 putative RNA binding site [nucleotide binding]; other site 478433003096 Mitochondrial ATP synthase g subunit; Region: ATP-synt_G; pfam04718 478433003097 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 478433003098 NusA N-terminal domain; Region: NusA_N; pfam08529 478433003099 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 478433003100 RNA binding site [nucleotide binding]; other site 478433003101 homodimer interface [polypeptide binding]; other site 478433003102 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 478433003103 G-X-X-G motif; other site 478433003104 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 478433003105 G-X-X-G motif; other site 478433003106 Predicted nucleic-acid-binding protein implicated in transcription termination [Transcription]; Region: COG2740 478433003107 putative RNA binding cleft [nucleotide binding]; other site 478433003108 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 478433003109 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 478433003110 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 478433003111 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 478433003112 G1 box; other site 478433003113 putative GEF interaction site [polypeptide binding]; other site 478433003114 GTP/Mg2+ binding site [chemical binding]; other site 478433003115 Switch I region; other site 478433003116 G2 box; other site 478433003117 G3 box; other site 478433003118 Switch II region; other site 478433003119 G4 box; other site 478433003120 G5 box; other site 478433003121 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 478433003122 Translation-initiation factor 2; Region: IF-2; pfam11987 478433003123 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 478433003124 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 478433003125 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 478433003126 DHH family; Region: DHH; pfam01368 478433003127 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 478433003128 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 478433003129 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 478433003130 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 478433003131 dimer interface [polypeptide binding]; other site 478433003132 conserved gate region; other site 478433003133 putative PBP binding loops; other site 478433003134 ABC-ATPase subunit interface; other site 478433003135 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 478433003136 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 478433003137 dimer interface [polypeptide binding]; other site 478433003138 conserved gate region; other site 478433003139 putative PBP binding loops; other site 478433003140 ABC-ATPase subunit interface; other site 478433003141 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 478433003142 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 478433003143 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 478433003144 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 478433003145 Walker A/P-loop; other site 478433003146 ATP binding site [chemical binding]; other site 478433003147 Q-loop/lid; other site 478433003148 ABC transporter signature motif; other site 478433003149 Walker B; other site 478433003150 D-loop; other site 478433003151 H-loop/switch region; other site 478433003152 enoyl-CoA hydratase; Provisional; Region: PRK06190 478433003153 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 478433003154 substrate binding site [chemical binding]; other site 478433003155 oxyanion hole (OAH) forming residues; other site 478433003156 trimer interface [polypeptide binding]; other site 478433003157 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 478433003158 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 478433003159 putative active site [active] 478433003160 Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041 478433003161 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4293 478433003162 Protein of unknown function (DUF2005); Region: DUF2005; pfam09407 478433003163 Uncharacterized conserved protein [Function unknown]; Region: COG2253 478433003164 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4293 478433003165 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 478433003166 Predicted CRISPR-associated polymerase [Defense mechanisms]; Region: COG1353 478433003167 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680 478433003168 CRISPR/Cas system-associated protein Csm2; Region: Csm2_III-A; cd09647 478433003169 CRISPR/Cas system-associated RAMP superfamily protein Csm3; Region: Csm3_III-A; cd09684 478433003170 CRISPR/Cas system-associated RAMP superfamily protein Csm4; Region: Csm4_III-A; cd09663 478433003171 CRISPR/Cas system-associated RAMP superfamily protein Csm5; Region: Csm5_III-A; cd09662 478433003172 CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cd09699 478433003173 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09636 478433003174 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638 478433003175 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 478433003176 Transposase; Region: HTH_Tnp_1; cl17663 478433003177 putative transposase OrfB; Reviewed; Region: PHA02517 478433003178 HTH-like domain; Region: HTH_21; pfam13276 478433003179 Integrase core domain; Region: rve; pfam00665 478433003180 Integrase core domain; Region: rve_3; pfam13683 478433003181 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 478433003182 Helix-turn-helix domain; Region: HTH_28; pfam13518 478433003183 Winged helix-turn helix; Region: HTH_29; pfam13551 478433003184 Integrase core domain; Region: rve; pfam00665 478433003185 Integrase core domain; Region: rve_3; pfam13683 478433003186 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 478433003187 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 478433003188 Transposase; Region: DDE_Tnp_ISL3; pfam01610 478433003189 Integrase core domain; Region: rve; pfam00665 478433003190 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 478433003191 Uncharacterized conserved protein [Function unknown]; Region: COG5586 478433003192 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 478433003193 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 478433003194 Predicted acyl esterases [General function prediction only]; Region: COG2936 478433003195 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 478433003196 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 478433003197 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 478433003198 Uncharacterized conserved protein [Function unknown]; Region: COG4717 478433003199 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 478433003200 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 478433003201 active site 478433003202 metal binding site [ion binding]; metal-binding site 478433003203 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 478433003204 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 478433003205 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 478433003206 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 478433003207 RNA binding site [nucleotide binding]; other site 478433003208 active site 478433003209 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 478433003210 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 478433003211 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 478433003212 catalytic residues [active] 478433003213 catalytic nucleophile [active] 478433003214 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 478433003215 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 478433003216 Probable transposase; Region: OrfB_IS605; pfam01385 478433003217 lipid-transfer protein; Provisional; Region: PRK08256 478433003218 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 478433003219 active site 478433003220 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 478433003221 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 478433003222 active site 478433003223 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 478433003224 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 478433003225 putative DNA binding site [nucleotide binding]; other site 478433003226 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 478433003227 FeoA domain; Region: FeoA; pfam04023 478433003228 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 478433003229 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 478433003230 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 478433003231 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 478433003232 active site 478433003233 Riboflavin kinase; Region: Flavokinase; pfam01687 478433003234 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 478433003235 16S/18S rRNA binding site [nucleotide binding]; other site 478433003236 S13e-L30e interaction site [polypeptide binding]; other site 478433003237 25S rRNA binding site [nucleotide binding]; other site 478433003238 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 478433003239 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 478433003240 oligomer interface [polypeptide binding]; other site 478433003241 RNA binding site [nucleotide binding]; other site 478433003242 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 478433003243 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 478433003244 RNase E interface [polypeptide binding]; other site 478433003245 trimer interface [polypeptide binding]; other site 478433003246 active site 478433003247 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 478433003248 putative nucleic acid binding region [nucleotide binding]; other site 478433003249 G-X-X-G motif; other site 478433003250 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 478433003251 RNA binding site [nucleotide binding]; other site 478433003252 domain interface; other site 478433003253 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 478433003254 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 478433003255 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 478433003256 Nitronate monooxygenase; Region: NMO; pfam03060 478433003257 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 478433003258 FMN binding site [chemical binding]; other site 478433003259 substrate binding site [chemical binding]; other site 478433003260 putative catalytic residue [active] 478433003261 alanine dehydrogenase; Region: alaDH; TIGR00518 478433003262 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 478433003263 hexamer interface [polypeptide binding]; other site 478433003264 ligand binding site [chemical binding]; other site 478433003265 putative active site [active] 478433003266 NAD(P) binding site [chemical binding]; other site 478433003267 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 478433003268 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 478433003269 putative DNA binding site [nucleotide binding]; other site 478433003270 putative Zn2+ binding site [ion binding]; other site 478433003271 AsnC family; Region: AsnC_trans_reg; pfam01037 478433003272 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 478433003273 hydrophobic ligand binding site; other site 478433003274 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 478433003275 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 478433003276 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 478433003277 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 478433003278 FMN-binding pocket [chemical binding]; other site 478433003279 flavin binding motif; other site 478433003280 phosphate binding motif [ion binding]; other site 478433003281 beta-alpha-beta structure motif; other site 478433003282 NAD binding pocket [chemical binding]; other site 478433003283 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 478433003284 catalytic loop [active] 478433003285 iron binding site [ion binding]; other site 478433003286 putative transposase OrfB; Reviewed; Region: PHA02517 478433003287 HTH-like domain; Region: HTH_21; pfam13276 478433003288 Integrase core domain; Region: rve; pfam00665 478433003289 Integrase core domain; Region: rve_3; pfam13683 478433003290 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 478433003291 Transposase; Region: HTH_Tnp_1; cl17663 478433003292 dihydrodipicolinate reductase; Provisional; Region: PRK00048 478433003293 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 478433003294 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 478433003295 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 478433003296 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478433003297 PPE family; Region: PPE; pfam00823 478433003298 PE family; Region: PE; pfam00934 478433003299 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 478433003300 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478433003301 PPE family; Region: PPE; pfam00823 478433003302 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 478433003303 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 478433003304 classical (c) SDRs; Region: SDR_c; cd05233 478433003305 NAD(P) binding site [chemical binding]; other site 478433003306 active site 478433003307 Dienelactone hydrolase family; Region: DLH; pfam01738 478433003308 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 478433003309 thymidylate synthase; Reviewed; Region: thyA; PRK01827 478433003310 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 478433003311 dimerization interface [polypeptide binding]; other site 478433003312 active site 478433003313 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 478433003314 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 478433003315 folate binding site [chemical binding]; other site 478433003316 NADP+ binding site [chemical binding]; other site 478433003317 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 478433003318 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 478433003319 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 478433003320 Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704 478433003321 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 478433003322 putative active site [active] 478433003323 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 478433003324 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 478433003325 putative active site [active] 478433003326 HsdM N-terminal domain; Region: HsdM_N; pfam12161 478433003327 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 478433003328 Methyltransferase domain; Region: Methyltransf_26; pfam13659 478433003329 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 478433003330 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 478433003331 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 478433003332 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 478433003333 dimer interface [polypeptide binding]; other site 478433003334 active site 478433003335 catalytic residue [active] 478433003336 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 478433003337 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 478433003338 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 478433003339 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 478433003340 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 478433003341 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 478433003342 classical (c) SDRs; Region: SDR_c; cd05233 478433003343 NAD(P) binding site [chemical binding]; other site 478433003344 active site 478433003345 Uncharacterized conserved protein [Function unknown]; Region: COG1359 478433003346 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 478433003347 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 478433003348 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 478433003349 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 478433003350 Coenzyme A binding pocket [chemical binding]; other site 478433003351 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 478433003352 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 478433003353 non-specific DNA binding site [nucleotide binding]; other site 478433003354 salt bridge; other site 478433003355 sequence-specific DNA binding site [nucleotide binding]; other site 478433003356 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 478433003357 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 478433003358 PE family; Region: PE; pfam00934 478433003359 Limonene-1,2-epoxide hydrolase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LimA; COG4308 478433003360 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 478433003361 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 478433003362 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 478433003363 DNA recombination protein RecA; Reviewed; Region: recA; PRK09519 478433003364 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 478433003365 hexamer interface [polypeptide binding]; other site 478433003366 Walker A motif; other site 478433003367 ATP binding site [chemical binding]; other site 478433003368 Walker B motif; other site 478433003369 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 478433003370 protein-splicing catalytic site; other site 478433003371 thioester formation/cholesterol transfer; other site 478433003372 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 478433003373 recA bacterial DNA recombination protein; Region: RecA; cl17211 478433003374 Uncharacterized protein conserved in bacteria [General function prediction only]; Region: OraA; COG2137 478433003375 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 478433003376 FeS/SAM binding site; other site 478433003377 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 478433003378 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 478433003379 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 478433003380 FeS/SAM binding site; other site 478433003381 TRAM domain; Region: TRAM; cl01282 478433003382 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 478433003383 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 478433003384 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 478433003385 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 478433003386 active site 478433003387 metal binding site [ion binding]; metal-binding site 478433003388 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 478433003389 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 478433003390 diaminopimelate epimerase; Region: DapF; TIGR00652 478433003391 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 478433003392 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 478433003393 GTPases [General function prediction only]; Region: HflX; COG2262 478433003394 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 478433003395 HflX GTPase family; Region: HflX; cd01878 478433003396 G1 box; other site 478433003397 GTP/Mg2+ binding site [chemical binding]; other site 478433003398 Switch I region; other site 478433003399 G2 box; other site 478433003400 G3 box; other site 478433003401 Switch II region; other site 478433003402 G4 box; other site 478433003403 G5 box; other site 478433003404 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 478433003405 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 478433003406 active site 478433003407 Integral membrane protein TerC family; Region: TerC; cl10468 478433003408 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 478433003409 LGFP repeat; Region: LGFP; pfam08310 478433003410 LGFP repeat; Region: LGFP; pfam08310 478433003411 LGFP repeat; Region: LGFP; pfam08310 478433003412 LGFP repeat; Region: LGFP; pfam08310 478433003413 LGFP repeat; Region: LGFP; pfam08310 478433003414 LexA repressor; Validated; Region: PRK00215 478433003415 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 478433003416 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 478433003417 Catalytic site [active] 478433003418 LysM domain; Region: LysM; pfam01476 478433003419 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 478433003420 ATP cone domain; Region: ATP-cone; pfam03477 478433003421 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 478433003422 heme-binding site [chemical binding]; other site 478433003423 Phenazine biosynthesis-like protein; Region: PhzC-PhzF; pfam02567 478433003424 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 478433003425 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 478433003426 PAC2 family; Region: PAC2; pfam09754 478433003427 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 478433003428 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 478433003429 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 478433003430 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 478433003431 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 478433003432 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 478433003433 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 478433003434 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 478433003435 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 478433003436 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 478433003437 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 478433003438 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 478433003439 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 478433003440 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 478433003441 DNA binding residues [nucleotide binding] 478433003442 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 478433003443 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 478433003444 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 478433003445 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3502 478433003446 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 478433003447 homotrimer interaction site [polypeptide binding]; other site 478433003448 putative active site [active] 478433003449 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 478433003450 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 478433003451 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 478433003452 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 478433003453 DNA binding residues [nucleotide binding] 478433003454 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 478433003455 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 478433003456 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 478433003457 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 478433003458 active site 478433003459 dimerization interface [polypeptide binding]; other site 478433003460 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 478433003461 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 478433003462 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 478433003463 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 478433003464 trimer interface [polypeptide binding]; other site 478433003465 active site 478433003466 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 478433003467 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 478433003468 generic binding surface II; other site 478433003469 ssDNA binding site; other site 478433003470 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 478433003471 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 478433003472 TrkA-N domain; Region: TrkA_N; pfam02254 478433003473 TrkA-C domain; Region: TrkA_C; pfam02080 478433003474 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 478433003475 TrkA-N domain; Region: TrkA_N; pfam02254 478433003476 TrkA-C domain; Region: TrkA_C; pfam02080 478433003477 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 478433003478 TRAM domain; Region: TRAM; cl01282 478433003479 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 478433003480 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 478433003481 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 478433003482 Walker A/P-loop; other site 478433003483 ATP binding site [chemical binding]; other site 478433003484 Q-loop/lid; other site 478433003485 ABC transporter signature motif; other site 478433003486 Walker B; other site 478433003487 D-loop; other site 478433003488 H-loop/switch region; other site 478433003489 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 478433003490 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 478433003491 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 478433003492 transmembrane helices; other site 478433003493 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 478433003494 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 478433003495 transmembrane helices; other site 478433003496 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 478433003497 Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154 478433003498 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 478433003499 TPP-binding site; other site 478433003500 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 478433003501 PYR/PP interface [polypeptide binding]; other site 478433003502 dimer interface [polypeptide binding]; other site 478433003503 TPP binding site [chemical binding]; other site 478433003504 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 478433003505 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 478433003506 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 478433003507 catalytic site [active] 478433003508 putative active site [active] 478433003509 putative substrate binding site [chemical binding]; other site 478433003510 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 478433003511 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 478433003512 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 478433003513 substrate binding site [chemical binding]; other site 478433003514 oxyanion hole (OAH) forming residues; other site 478433003515 trimer interface [polypeptide binding]; other site 478433003516 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 478433003517 substrate binding site [chemical binding]; other site 478433003518 active site 478433003519 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 478433003520 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 478433003521 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 478433003522 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 478433003523 Methyltransferase domain; Region: Methyltransf_31; pfam13847 478433003524 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478433003525 S-adenosylmethionine binding site [chemical binding]; other site 478433003526 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 478433003527 SelR domain; Region: SelR; pfam01641 478433003528 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 478433003529 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 478433003530 TAP-like protein; Region: Abhydrolase_4; pfam08386 478433003531 hypothetical protein; Provisional; Region: PRK14059 478433003532 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 478433003533 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 478433003534 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 478433003535 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 478433003536 Coenzyme A binding pocket [chemical binding]; other site 478433003537 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 478433003538 Transposase, Mutator family; Region: Transposase_mut; pfam00872 478433003539 MULE transposase domain; Region: MULE; pfam10551 478433003540 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 478433003541 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 478433003542 active site 478433003543 catalytic residues [active] 478433003544 DNA binding site [nucleotide binding] 478433003545 Int/Topo IB signature motif; other site 478433003546 DNA binding domain, excisionase family; Region: excise; TIGR01764 478433003547 Protein of unknown function (DUF2742); Region: DUF2742; pfam10888 478433003548 Protein of unknown function (DUF3631); Region: DUF3631; pfam12307 478433003549 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: COG3747 478433003550 Phage head maturation protease [General function prediction only]; Region: COG3740 478433003551 Predicted phage phi-C31 gp36 major capsid-like protein [General function prediction only]; Region: COG4653 478433003552 Phage capsid family; Region: Phage_capsid; pfam05065 478433003553 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 478433003554 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 478433003555 active site 478433003556 DNA binding site [nucleotide binding] 478433003557 Int/Topo IB signature motif; other site 478433003558 Protein of unknown function (DUF3018); Region: DUF3018; pfam11455 478433003559 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 478433003560 arsenical-resistance protein; Region: acr3; TIGR00832 478433003561 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 478433003562 Low molecular weight phosphatase family; Region: LMWPc; cd00115 478433003563 active site 478433003564 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 478433003565 dimerization interface [polypeptide binding]; other site 478433003566 putative DNA binding site [nucleotide binding]; other site 478433003567 putative Zn2+ binding site [ion binding]; other site 478433003568 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 478433003569 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 478433003570 putative metal binding site [ion binding]; other site 478433003571 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 478433003572 Transcriptional regulators [Transcription]; Region: MarR; COG1846 478433003573 putative DNA binding site [nucleotide binding]; other site 478433003574 putative Zn2+ binding site [ion binding]; other site 478433003575 hypothetical protein; Provisional; Region: PRK02237 478433003576 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 478433003577 anti sigma factor interaction site; other site 478433003578 regulatory phosphorylation site [posttranslational modification]; other site 478433003579 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 478433003580 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 478433003581 Chloramphenicol (Cm) phosphotransferase (CPT). Cm-inactivating enzyme; modifies the primary (C-3) hydroxyl of the antibiotic. Related structurally to shikimate kinase II; Region: CPT; cd00227 478433003582 P-loop motif; other site 478433003583 ATP binding site [chemical binding]; other site 478433003584 Chloramphenicol (Cm) binding site [chemical binding]; other site 478433003585 catalytic residue [active] 478433003586 PE family; Region: PE; pfam00934 478433003587 Hemerythrin-like domain; Region: Hr-like; cd12108 478433003588 Fe binding site [ion binding]; other site 478433003589 Domain of unknown function (DUF1876); Region: DUF1876; pfam08962 478433003590 Uncharacterized conserved protein [Function unknown]; Region: RtcB; COG1690 478433003591 hypothetical protein; Reviewed; Region: PRK09588 478433003592 SHS2 domain protein implicated in nucleic acid metabolism [General function prediction only]; Region: COG1371 478433003593 peptide chain release factor 1; Provisional; Region: PRK04011 478433003594 FOG: CBS domain [General function prediction only]; Region: COG0517 478433003595 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 478433003596 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 478433003597 active site 478433003598 Peptidase family M50; Region: Peptidase_M50; pfam02163 478433003599 putative substrate binding region [chemical binding]; other site 478433003600 FOG: CBS domain [General function prediction only]; Region: COG0517 478433003601 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612 478433003602 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 478433003603 Ligand Binding Site [chemical binding]; other site 478433003604 Universal stress protein family; Region: Usp; pfam00582 478433003605 Ligand Binding Site [chemical binding]; other site 478433003606 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 478433003607 Ligand Binding Site [chemical binding]; other site 478433003608 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 478433003609 Ligand Binding Site [chemical binding]; other site 478433003610 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478433003611 S-adenosylmethionine binding site [chemical binding]; other site 478433003612 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 478433003613 Predicted transcriptional regulator [Transcription]; Region: COG2345 478433003614 Helix-turn-helix domain; Region: HTH_20; pfam12840 478433003615 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 478433003616 Helix-turn-helix domain; Region: HTH_20; pfam12840 478433003617 Predicted transcriptional regulator [Transcription]; Region: COG2345 478433003618 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4762 478433003619 PE family; Region: PE; pfam00934 478433003620 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 478433003621 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 478433003622 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 478433003623 active site 478433003624 dimer interface [polypeptide binding]; other site 478433003625 motif 1; other site 478433003626 motif 2; other site 478433003627 motif 3; other site 478433003628 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 478433003629 anticodon binding site; other site 478433003630 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 478433003631 nucleotide binding site/active site [active] 478433003632 HIT family signature motif; other site 478433003633 catalytic residue [active] 478433003634 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 478433003635 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 478433003636 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 478433003637 putative acyl-acceptor binding pocket; other site 478433003638 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 478433003639 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 478433003640 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_26; cd04685 478433003641 nudix motif; other site 478433003642 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478433003643 PPE family; Region: PPE; pfam00823 478433003644 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478433003645 PE-PPE domain; Region: PE-PPE; pfam08237 478433003646 Pyridoxamine-phosphate oxidase [Coenzyme metabolism]; Region: PdxH; COG0259 478433003647 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 478433003648 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 478433003649 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 478433003650 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 478433003651 active site 478433003652 multimer interface [polypeptide binding]; other site 478433003653 acyl-CoA thioesterase II; Region: tesB; TIGR00189 478433003654 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 478433003655 active site 478433003656 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 478433003657 catalytic triad [active] 478433003658 dimer interface [polypeptide binding]; other site 478433003659 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 478433003660 predicted active site [active] 478433003661 catalytic triad [active] 478433003662 hypothetical protein; Validated; Region: PRK00110 478433003663 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 478433003664 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 478433003665 Predicted spermidine synthase with an N-terminal membrane domain [General function prediction only]; Region: COG4262 478433003666 Spermine/spermidine synthase; Region: Spermine_synth; pfam01564 478433003667 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 478433003668 Domain of unknown function (DUF4247); Region: DUF4247; pfam14042 478433003669 Protein of unknown function DUF2617; Region: DUF2617; pfam10936 478433003670 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 478433003671 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 478433003672 putative active site [active] 478433003673 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 478433003674 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 478433003675 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 478433003676 active site 478433003677 putative DNA-binding cleft [nucleotide binding]; other site 478433003678 dimer interface [polypeptide binding]; other site 478433003679 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 478433003680 RuvA N terminal domain; Region: RuvA_N; pfam01330 478433003681 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 478433003682 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 478433003683 Walker A motif; other site 478433003684 ATP binding site [chemical binding]; other site 478433003685 Walker B motif; other site 478433003686 arginine finger; other site 478433003687 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 478433003688 PE family; Region: PE; pfam00934 478433003689 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 478433003690 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 478433003691 acyl-activating enzyme (AAE) consensus motif; other site 478433003692 AMP binding site [chemical binding]; other site 478433003693 active site 478433003694 CoA binding site [chemical binding]; other site 478433003695 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 478433003696 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 478433003697 putative NAD(P) binding site [chemical binding]; other site 478433003698 active site 478433003699 putative substrate binding site [chemical binding]; other site 478433003700 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 478433003701 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 478433003702 inhibitor-cofactor binding pocket; inhibition site 478433003703 pyridoxal 5'-phosphate binding site [chemical binding]; other site 478433003704 catalytic residue [active] 478433003705 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05886 478433003706 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 478433003707 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 478433003708 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 478433003709 Protein export membrane protein; Region: SecD_SecF; pfam02355 478433003710 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 478433003711 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 478433003712 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 478433003713 active site 478433003714 (p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691 478433003715 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 478433003716 Zn2+ binding site [ion binding]; other site 478433003717 Mg2+ binding site [ion binding]; other site 478433003718 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 478433003719 synthetase active site [active] 478433003720 NTP binding site [chemical binding]; other site 478433003721 metal binding site [ion binding]; metal-binding site 478433003722 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 478433003723 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 478433003724 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 478433003725 active site 478433003726 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 478433003727 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 478433003728 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 478433003729 dimer interface [polypeptide binding]; other site 478433003730 motif 1; other site 478433003731 active site 478433003732 motif 2; other site 478433003733 motif 3; other site 478433003734 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 478433003735 anticodon binding site; other site 478433003736 haloalkane dehalogenase; Provisional; Region: PRK03592 478433003737 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 478433003738 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 478433003739 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 478433003740 active site 478433003741 metal binding site [ion binding]; metal-binding site 478433003742 Predicted metalloprotease [General function prediction only]; Region: COG2321 478433003743 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 478433003744 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 478433003745 putative hydrophobic ligand binding site [chemical binding]; other site 478433003746 protein interface [polypeptide binding]; other site 478433003747 gate; other site 478433003748 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 478433003749 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 478433003750 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 478433003751 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 478433003752 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 478433003753 dimer interface [polypeptide binding]; other site 478433003754 anticodon binding site; other site 478433003755 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 478433003756 homodimer interface [polypeptide binding]; other site 478433003757 motif 1; other site 478433003758 active site 478433003759 motif 2; other site 478433003760 GAD domain; Region: GAD; pfam02938 478433003761 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 478433003762 active site 478433003763 motif 3; other site 478433003764 Predicted membrane protein [Function unknown]; Region: COG4129 478433003765 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 478433003766 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3801 478433003767 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 478433003768 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 478433003769 Transglutaminase/protease-like homologues; Region: TGc; smart00460 478433003770 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307 478433003771 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 478433003772 Uncharacterized conserved protein [Function unknown]; Region: COG2308 478433003773 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 478433003774 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 478433003775 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 478433003776 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 478433003777 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 478433003778 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 478433003779 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 478433003780 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 478433003781 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 478433003782 ligand binding site [chemical binding]; other site 478433003783 flexible hinge region; other site 478433003784 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 478433003785 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 478433003786 active site 478433003787 nucleophile elbow; other site 478433003788 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 478433003789 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 478433003790 Walker A/P-loop; other site 478433003791 ATP binding site [chemical binding]; other site 478433003792 Q-loop/lid; other site 478433003793 ABC transporter signature motif; other site 478433003794 Walker B; other site 478433003795 D-loop; other site 478433003796 H-loop/switch region; other site 478433003797 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 478433003798 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 478433003799 ligand binding site [chemical binding]; other site 478433003800 flexible hinge region; other site 478433003801 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 478433003802 Protein of unknown function (DUF2652); Region: DUF2652; pfam10851 478433003803 Predicted integral membrane protein [Function unknown]; Region: COG5473 478433003804 recombination factor protein RarA; Reviewed; Region: PRK13342 478433003805 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 478433003806 Walker A motif; other site 478433003807 ATP binding site [chemical binding]; other site 478433003808 Walker B motif; other site 478433003809 arginine finger; other site 478433003810 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 478433003811 Uncharacterized conserved protein [Function unknown]; Region: COG0432 478433003812 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 478433003813 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 478433003814 motif 1; other site 478433003815 active site 478433003816 motif 2; other site 478433003817 motif 3; other site 478433003818 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 478433003819 DHHA1 domain; Region: DHHA1; pfam02272 478433003820 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 478433003821 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 478433003822 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 478433003823 dimerization interface [polypeptide binding]; other site 478433003824 shikimate-5-dehydrogenase, fungal AROM-type; Region: Shik-DH-AROM; TIGR01809 478433003825 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 478433003826 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 478433003827 NAD(P) binding site [chemical binding]; other site 478433003828 shikimate binding site; other site 478433003829 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 478433003830 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 478433003831 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 478433003832 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2402 478433003833 putative active site [active] 478433003834 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 478433003835 oligomeric interface; other site 478433003836 putative active site [active] 478433003837 homodimer interface [polypeptide binding]; other site 478433003838 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 478433003839 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 478433003840 putative active site [active] 478433003841 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 478433003842 digalactosyldiacylglycerol synthase; Region: PLN02846 478433003843 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 478433003844 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 478433003845 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 478433003846 Tetramer interface [polypeptide binding]; other site 478433003847 active site 478433003848 FMN-binding site [chemical binding]; other site 478433003849 shikimate kinase; Reviewed; Region: aroK; PRK00131 478433003850 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 478433003851 ADP binding site [chemical binding]; other site 478433003852 magnesium binding site [ion binding]; other site 478433003853 putative shikimate binding site; other site 478433003854 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 478433003855 active site 478433003856 dimer interface [polypeptide binding]; other site 478433003857 metal binding site [ion binding]; metal-binding site 478433003858 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 478433003859 Dehydroquinase class II; Region: DHquinase_II; pfam01220 478433003860 trimer interface [polypeptide binding]; other site 478433003861 active site 478433003862 dimer interface [polypeptide binding]; other site 478433003863 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 478433003864 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 478433003865 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 478433003866 active site 478433003867 elongation factor P; Validated; Region: PRK00529 478433003868 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 478433003869 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 478433003870 RNA binding site [nucleotide binding]; other site 478433003871 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 478433003872 RNA binding site [nucleotide binding]; other site 478433003873 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 478433003874 putative RNA binding site [nucleotide binding]; other site 478433003875 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 478433003876 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 478433003877 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 478433003878 catalytic residue [active] 478433003879 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 478433003880 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 478433003881 putative active site [active] 478433003882 ERCC4 domain; Region: ERCC4; pfam02732 478433003883 Lsr2; Region: Lsr2; pfam11774 478433003884 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 478433003885 Mrr N-terminal domain; Region: Mrr_N; pfam14338 478433003886 Restriction endonuclease; Region: Mrr_cat; pfam04471 478433003887 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 478433003888 putative active site [active] 478433003889 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 478433003890 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 478433003891 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 478433003892 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 478433003893 phosphate binding site [ion binding]; other site 478433003894 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 478433003895 FAS_MaoC, the MaoC-like hot dog fold of the fatty acid synthase, beta subunit. Other enzymes with this fold include MaoC dehydratase, Hydratase-Dehydrogenase-Epimerase protein (HDE), and 17-beta-hydroxysteriod dehydrogenase (HSD); Region: FAS_MaoC; cd03447 478433003896 putative active site [active] 478433003897 putative catalytic site [active] 478433003898 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 478433003899 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 478433003900 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 478433003901 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 478433003902 putative NAD(P) binding site [chemical binding]; other site 478433003903 active site 478433003904 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 478433003905 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 478433003906 active site 478433003907 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 478433003908 hypothetical protein; Provisional; Region: PRK07907 478433003909 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 478433003910 active site 478433003911 metal binding site [ion binding]; metal-binding site 478433003912 dimer interface [polypeptide binding]; other site 478433003913 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 478433003914 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 478433003915 catalytic triad [active] 478433003916 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 478433003917 PE family; Region: PE; pfam00934 478433003918 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 478433003919 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 478433003920 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 478433003921 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 478433003922 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2739; cl17893 478433003923 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 478433003924 non-specific DNA binding site [nucleotide binding]; other site 478433003925 salt bridge; other site 478433003926 sequence-specific DNA binding site [nucleotide binding]; other site 478433003927 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 478433003928 Domain of unknown function (DUF4411); Region: DUF4411; pfam14367 478433003929 Transposase, Mutator family; Region: Transposase_mut; pfam00872 478433003930 MULE transposase domain; Region: MULE; pfam10551 478433003931 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 478433003932 catalytic site [active] 478433003933 putative active site [active] 478433003934 putative substrate binding site [chemical binding]; other site 478433003935 dimer interface [polypeptide binding]; other site 478433003936 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 478433003937 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 478433003938 classical (c) SDRs; Region: SDR_c; cd05233 478433003939 NAD(P) binding site [chemical binding]; other site 478433003940 active site 478433003941 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 478433003942 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 478433003943 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478433003944 AMP-binding domain protein; Validated; Region: PRK08315 478433003945 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 478433003946 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 478433003947 acyl-activating enzyme (AAE) consensus motif; other site 478433003948 acyl-activating enzyme (AAE) consensus motif; other site 478433003949 putative AMP binding site [chemical binding]; other site 478433003950 putative active site [active] 478433003951 putative CoA binding site [chemical binding]; other site 478433003952 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 478433003953 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 478433003954 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 478433003955 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 478433003956 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 478433003957 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 478433003958 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 478433003959 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 478433003960 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 478433003961 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 478433003962 carboxyltransferase (CT) interaction site; other site 478433003963 biotinylation site [posttranslational modification]; other site 478433003964 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 478433003965 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 478433003966 active site 478433003967 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 478433003968 putative active site [active] 478433003969 putative catalytic site [active] 478433003970 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 478433003971 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 478433003972 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 478433003973 tetramer interface [polypeptide binding]; other site 478433003974 TPP-binding site [chemical binding]; other site 478433003975 heterodimer interface [polypeptide binding]; other site 478433003976 phosphorylation loop region [posttranslational modification] 478433003977 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 478433003978 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 478433003979 alpha subunit interface [polypeptide binding]; other site 478433003980 TPP binding site [chemical binding]; other site 478433003981 heterodimer interface [polypeptide binding]; other site 478433003982 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 478433003983 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 478433003984 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 478433003985 E3 interaction surface; other site 478433003986 lipoyl attachment site [posttranslational modification]; other site 478433003987 e3 binding domain; Region: E3_binding; pfam02817 478433003988 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 478433003989 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 478433003990 putative transposase OrfB; Reviewed; Region: PHA02517 478433003991 HTH-like domain; Region: HTH_21; pfam13276 478433003992 Integrase core domain; Region: rve; pfam00665 478433003993 Integrase core domain; Region: rve_3; pfam13683 478433003994 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 478433003995 Transposase; Region: HTH_Tnp_1; cl17663 478433003996 TIGR00725 family protein; Region: TIGR00725 478433003997 PE family; Region: PE; pfam00934 478433003998 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 478433003999 cyclase homology domain; Region: CHD; cd07302 478433004000 nucleotidyl binding site; other site 478433004001 metal binding site [ion binding]; metal-binding site 478433004002 dimer interface [polypeptide binding]; other site 478433004003 Predicted ATPase [General function prediction only]; Region: COG3903 478433004004 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 478433004005 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 478433004006 DNA binding residues [nucleotide binding] 478433004007 dimerization interface [polypeptide binding]; other site 478433004008 PE family; Region: PE; pfam00934 478433004009 enoyl-CoA hydratase; Provisional; Region: PRK05870 478433004010 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 478433004011 substrate binding site [chemical binding]; other site 478433004012 oxyanion hole (OAH) forming residues; other site 478433004013 trimer interface [polypeptide binding]; other site 478433004014 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 478433004015 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 478433004016 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 478433004017 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 478433004018 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 478433004019 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 478433004020 HAD-superfamily subfamily IB hydrolase, TIGR01490; Region: HAD-SF-IB-hyp1 478433004021 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 478433004022 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 478433004023 putative acyl-acceptor binding pocket; other site 478433004024 glycerol-3-phosphate acyltransferase; Validated; Region: PRK03355 478433004025 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 478433004026 putative acyl-acceptor binding pocket; other site 478433004027 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 478433004028 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 478433004029 dimer interface [polypeptide binding]; other site 478433004030 ssDNA binding site [nucleotide binding]; other site 478433004031 tetramer (dimer of dimers) interface [polypeptide binding]; other site 478433004032 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 478433004033 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 478433004034 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 478433004035 ABC transporter; Region: ABC_tran_2; pfam12848 478433004036 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 478433004037 NAD-specific glutamate dehydrogenase [Amino acid transport and metabolism]; Region: COG2902 478433004038 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 478433004039 active site 478433004040 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 478433004041 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 478433004042 active site 478433004043 catalytic site [active] 478433004044 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 478433004045 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 478433004046 apolar tunnel; other site 478433004047 heme binding site [chemical binding]; other site 478433004048 dimerization interface [polypeptide binding]; other site 478433004049 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 478433004050 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 478433004051 active site 478433004052 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 478433004053 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 478433004054 Zn binding site [ion binding]; other site 478433004055 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 478433004056 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 478433004057 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 478433004058 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 478433004059 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 478433004060 putative DNA binding site [nucleotide binding]; other site 478433004061 catalytic residue [active] 478433004062 putative H2TH interface [polypeptide binding]; other site 478433004063 putative catalytic residues [active] 478433004064 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 478433004065 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 478433004066 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 478433004067 Beta-lactamase; Region: Beta-lactamase; pfam00144 478433004068 trigger factor; Provisional; Region: tig; PRK01490 478433004069 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 478433004070 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 478433004071 Clp protease; Region: CLP_protease; pfam00574 478433004072 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 478433004073 oligomer interface [polypeptide binding]; other site 478433004074 active site residues [active] 478433004075 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 478433004076 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 478433004077 oligomer interface [polypeptide binding]; other site 478433004078 active site residues [active] 478433004079 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 478433004080 Major Facilitator Superfamily; Region: MFS_1; pfam07690 478433004081 putative substrate translocation pore; other site 478433004082 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 478433004083 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 478433004084 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 478433004085 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 478433004086 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 478433004087 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 478433004088 Walker A motif; other site 478433004089 ATP binding site [chemical binding]; other site 478433004090 Walker B motif; other site 478433004091 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 478433004092 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 478433004093 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 478433004094 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 478433004095 dimer interface [polypeptide binding]; other site 478433004096 PYR/PP interface [polypeptide binding]; other site 478433004097 TPP binding site [chemical binding]; other site 478433004098 substrate binding site [chemical binding]; other site 478433004099 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 478433004100 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 478433004101 TPP-binding site [chemical binding]; other site 478433004102 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 478433004103 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 478433004104 GTP binding site; other site 478433004105 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 478433004106 Uncharacterized conserved protein [Function unknown]; Region: COG3268 478433004107 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 478433004108 NAD(P) binding pocket [chemical binding]; other site 478433004109 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 478433004110 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 478433004111 active site 478433004112 HIGH motif; other site 478433004113 nucleotide binding site [chemical binding]; other site 478433004114 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 478433004115 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 478433004116 active site 478433004117 KMSKS motif; other site 478433004118 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 478433004119 tRNA binding surface [nucleotide binding]; other site 478433004120 anticodon binding site; other site 478433004121 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 478433004122 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 478433004123 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 478433004124 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 478433004125 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 478433004126 active site 478433004127 multimer interface [polypeptide binding]; other site 478433004128 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 478433004129 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 478433004130 homodimer interface [polypeptide binding]; other site 478433004131 oligonucleotide binding site [chemical binding]; other site 478433004132 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 478433004133 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 478433004134 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 478433004135 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 478433004136 GTPase CgtA; Reviewed; Region: obgE; PRK12296 478433004137 GTP1/OBG; Region: GTP1_OBG; pfam01018 478433004138 Obg GTPase; Region: Obg; cd01898 478433004139 G1 box; other site 478433004140 GTP/Mg2+ binding site [chemical binding]; other site 478433004141 Switch I region; other site 478433004142 G2 box; other site 478433004143 G3 box; other site 478433004144 Switch II region; other site 478433004145 G4 box; other site 478433004146 G5 box; other site 478433004147 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 478433004148 gamma-glutamyl kinase; Provisional; Region: PRK05429 478433004149 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 478433004150 nucleotide binding site [chemical binding]; other site 478433004151 homotetrameric interface [polypeptide binding]; other site 478433004152 putative phosphate binding site [ion binding]; other site 478433004153 putative allosteric binding site; other site 478433004154 PUA domain; Region: PUA; pfam01472 478433004155 NAD synthetase; Reviewed; Region: nadE; PRK02628 478433004156 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 478433004157 multimer interface [polypeptide binding]; other site 478433004158 active site 478433004159 catalytic triad [active] 478433004160 protein interface 1 [polypeptide binding]; other site 478433004161 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 478433004162 homodimer interface [polypeptide binding]; other site 478433004163 NAD binding pocket [chemical binding]; other site 478433004164 ATP binding pocket [chemical binding]; other site 478433004165 Mg binding site [ion binding]; other site 478433004166 active-site loop [active] 478433004167 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 478433004168 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 478433004169 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 478433004170 substrate binding site [chemical binding]; other site 478433004171 dimer interface [polypeptide binding]; other site 478433004172 ATP binding site [chemical binding]; other site 478433004173 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 478433004174 dimerization interface [polypeptide binding]; other site 478433004175 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 478433004176 cyclase homology domain; Region: CHD; cd07302 478433004177 nucleotidyl binding site; other site 478433004178 metal binding site [ion binding]; metal-binding site 478433004179 dimer interface [polypeptide binding]; other site 478433004180 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 478433004181 Mechanosensitive ion channel; Region: MS_channel; pfam00924 478433004182 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 478433004183 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 478433004184 ligand binding site [chemical binding]; other site 478433004185 flexible hinge region; other site 478433004186 PE family; Region: PE; pfam00934 478433004187 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478433004188 PPE family; Region: PPE; pfam00823 478433004189 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 478433004190 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 478433004191 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 478433004192 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 478433004193 dimer interface [polypeptide binding]; other site 478433004194 decamer (pentamer of dimers) interface [polypeptide binding]; other site 478433004195 catalytic triad [active] 478433004196 peroxidatic and resolving cysteines [active] 478433004197 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 478433004198 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 478433004199 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 478433004200 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 478433004201 putative catalytic cysteine [active] 478433004202 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 478433004203 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 478433004204 Walker A motif; other site 478433004205 ATP binding site [chemical binding]; other site 478433004206 Walker B motif; other site 478433004207 arginine finger; other site 478433004208 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 478433004209 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 478433004210 metal ion-dependent adhesion site (MIDAS); other site 478433004211 Transposase; Region: DEDD_Tnp_IS110; pfam01548 478433004212 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 478433004213 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 478433004214 Methyltransferase domain; Region: Methyltransf_23; pfam13489 478433004215 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478433004216 S-adenosylmethionine binding site [chemical binding]; other site 478433004217 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 478433004218 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 478433004219 active site 478433004220 (T/H)XGH motif; other site 478433004221 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 478433004222 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 478433004223 catalytic core [active] 478433004224 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 478433004225 active site 478433004226 catalytic triad [active] 478433004227 oxyanion hole [active] 478433004228 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307 478433004229 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 478433004230 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 478433004231 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 478433004232 Coenzyme A binding pocket [chemical binding]; other site 478433004233 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 478433004234 Helix-hairpin-helix motif; Region: HHH; pfam00633 478433004235 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 478433004236 Competence protein; Region: Competence; pfam03772 478433004237 hypothetical protein; Reviewed; Region: PRK07914 478433004238 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 478433004239 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 478433004240 Uncharacterized conserved protein [Function unknown]; Region: COG2308 478433004241 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 478433004242 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 478433004243 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 478433004244 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 478433004245 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 478433004246 PE family; Region: PE; pfam00934 478433004247 ribonuclease Z; Reviewed; Region: PRK00055 478433004248 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 478433004249 FOG: CBS domain [General function prediction only]; Region: COG0517 478433004250 PemK-like protein; Region: PemK; pfam02452 478433004251 GTP-binding protein LepA; Provisional; Region: PRK05433 478433004252 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 478433004253 G1 box; other site 478433004254 putative GEF interaction site [polypeptide binding]; other site 478433004255 GTP/Mg2+ binding site [chemical binding]; other site 478433004256 Switch I region; other site 478433004257 G2 box; other site 478433004258 G3 box; other site 478433004259 Switch II region; other site 478433004260 G4 box; other site 478433004261 G5 box; other site 478433004262 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 478433004263 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 478433004264 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 478433004265 PknH-like extracellular domain; Region: PknH_C; pfam14032 478433004266 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 478433004267 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 478433004268 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 478433004269 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 478433004270 sulfate transport protein; Provisional; Region: cysT; CHL00187 478433004271 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 478433004272 dimer interface [polypeptide binding]; other site 478433004273 conserved gate region; other site 478433004274 putative PBP binding loops; other site 478433004275 ABC-ATPase subunit interface; other site 478433004276 sulfate transport protein; Provisional; Region: cysT; CHL00187 478433004277 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 478433004278 dimer interface [polypeptide binding]; other site 478433004279 conserved gate region; other site 478433004280 putative PBP binding loops; other site 478433004281 ABC-ATPase subunit interface; other site 478433004282 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 478433004283 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 478433004284 Walker A/P-loop; other site 478433004285 ATP binding site [chemical binding]; other site 478433004286 Q-loop/lid; other site 478433004287 ABC transporter signature motif; other site 478433004288 Walker B; other site 478433004289 D-loop; other site 478433004290 H-loop/switch region; other site 478433004291 PE family; Region: PE; pfam00934 478433004292 Predicted membrane protein [Function unknown]; Region: COG1297 478433004293 putative oligopeptide transporter, OPT family; Region: TIGR00733 478433004294 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 478433004295 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 478433004296 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 478433004297 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 478433004298 putative active site [active] 478433004299 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 478433004300 putative active site [active] 478433004301 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 478433004302 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 478433004303 Active Sites [active] 478433004304 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 478433004305 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 478433004306 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 478433004307 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 478433004308 coproporphyrinogen III oxidase; Validated; Region: PRK05628 478433004309 Predicted permease [General function prediction only]; Region: COG3329 478433004310 salicylate synthase MbtI; Reviewed; Region: PRK07912 478433004311 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 478433004312 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 478433004313 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 478433004314 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 478433004315 acyl-activating enzyme (AAE) consensus motif; other site 478433004316 active site 478433004317 AMP binding site [chemical binding]; other site 478433004318 substrate binding site [chemical binding]; other site 478433004319 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 478433004320 Condensation domain; Region: Condensation; pfam00668 478433004321 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 478433004322 Nonribosomal peptide synthase; Region: NRPS; pfam08415 478433004323 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 478433004324 acyl-activating enzyme (AAE) consensus motif; other site 478433004325 AMP binding site [chemical binding]; other site 478433004326 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 478433004327 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 478433004328 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 478433004329 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 478433004330 active site 478433004331 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 478433004332 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 478433004333 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 478433004334 NADP binding site [chemical binding]; other site 478433004335 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 478433004336 active site 478433004337 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 478433004338 Condensation domain; Region: Condensation; pfam00668 478433004339 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 478433004340 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 478433004341 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 478433004342 acyl-activating enzyme (AAE) consensus motif; other site 478433004343 AMP binding site [chemical binding]; other site 478433004344 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 478433004345 Condensation domain; Region: Condensation; pfam00668 478433004346 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 478433004347 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 478433004348 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 478433004349 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 478433004350 Condensation domain; Region: Condensation; pfam00668 478433004351 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 478433004352 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 478433004353 acyl-activating enzyme (AAE) consensus motif; other site 478433004354 AMP binding site [chemical binding]; other site 478433004355 Condensation domain; Region: Condensation; pfam00668 478433004356 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 478433004357 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 478433004358 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 478433004359 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 478433004360 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 478433004361 chaperone protein DnaJ; Provisional; Region: PRK14278 478433004362 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 478433004363 HSP70 interaction site [polypeptide binding]; other site 478433004364 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 478433004365 Zn binding sites [ion binding]; other site 478433004366 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 478433004367 dimer interface [polypeptide binding]; other site 478433004368 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 478433004369 RNA methyltransferase, RsmE family; Region: TIGR00046 478433004370 PE family; Region: PE; pfam00934 478433004371 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 478433004372 K homology RNA-binding domain; Region: KH; smart00322 478433004373 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 478433004374 PhoH-like protein; Region: PhoH; pfam02562 478433004375 metal-binding heat shock protein; Provisional; Region: PRK00016 478433004376 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 478433004377 Domain of unknown function DUF21; Region: DUF21; pfam01595 478433004378 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 478433004379 Transporter associated domain; Region: CorC_HlyC; smart01091 478433004380 GTPase Era; Reviewed; Region: era; PRK00089 478433004381 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 478433004382 G1 box; other site 478433004383 GTP/Mg2+ binding site [chemical binding]; other site 478433004384 Switch I region; other site 478433004385 G2 box; other site 478433004386 Switch II region; other site 478433004387 G3 box; other site 478433004388 G4 box; other site 478433004389 G5 box; other site 478433004390 KH domain; Region: KH_2; pfam07650 478433004391 amidase; Provisional; Region: PRK06061 478433004392 Amidase; Region: Amidase; pfam01425 478433004393 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 478433004394 Recombination protein O N terminal; Region: RecO_N; pfam11967 478433004395 Recombination protein O C terminal; Region: RecO_C; pfam02565 478433004396 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 478433004397 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 478433004398 catalytic residue [active] 478433004399 putative FPP diphosphate binding site; other site 478433004400 putative FPP binding hydrophobic cleft; other site 478433004401 dimer interface [polypeptide binding]; other site 478433004402 putative IPP diphosphate binding site; other site 478433004403 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 478433004404 metal binding site 2 [ion binding]; metal-binding site 478433004405 putative DNA binding helix; other site 478433004406 metal binding site 1 [ion binding]; metal-binding site 478433004407 dimer interface [polypeptide binding]; other site 478433004408 structural Zn2+ binding site [ion binding]; other site 478433004409 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 478433004410 dimerization interface [polypeptide binding]; other site 478433004411 putative DNA binding site [nucleotide binding]; other site 478433004412 putative Zn2+ binding site [ion binding]; other site 478433004413 glycyl-tRNA synthetase; Provisional; Region: PRK04173 478433004414 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 478433004415 motif 1; other site 478433004416 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 478433004417 active site 478433004418 motif 2; other site 478433004419 motif 3; other site 478433004420 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 478433004421 anticodon binding site; other site 478433004422 PPE family; Region: PPE; pfam00823 478433004423 PPE family; Region: PPE; pfam00823 478433004424 PPE family; Region: PPE; pfam00823 478433004425 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478433004426 PPE family; Region: PPE; pfam00823 478433004427 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478433004428 PPE family; Region: PPE; pfam00823 478433004429 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 478433004430 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 478433004431 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 478433004432 Transposase; Region: HTH_Tnp_1; cl17663 478433004433 putative transposase OrfB; Reviewed; Region: PHA02517 478433004434 HTH-like domain; Region: HTH_21; pfam13276 478433004435 Integrase core domain; Region: rve; pfam00665 478433004436 Integrase core domain; Region: rve_3; pfam13683 478433004437 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478433004438 PPE family; Region: PPE; pfam00823 478433004439 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 478433004440 Phosphoesterase family; Region: Phosphoesterase; pfam04185 478433004441 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 478433004442 Phosphoesterase family; Region: Phosphoesterase; pfam04185 478433004443 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 478433004444 Phosphoesterase family; Region: Phosphoesterase; pfam04185 478433004445 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 478433004446 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 478433004447 Repair protein; Region: Repair_PSII; pfam04536 478433004448 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 478433004449 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 478433004450 Zn2+ binding site [ion binding]; other site 478433004451 Mg2+ binding site [ion binding]; other site 478433004452 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 478433004453 DNA primase; Validated; Region: dnaG; PRK05667 478433004454 CHC2 zinc finger; Region: zf-CHC2; pfam01807 478433004455 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 478433004456 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 478433004457 active site 478433004458 metal binding site [ion binding]; metal-binding site 478433004459 interdomain interaction site; other site 478433004460 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 478433004461 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 478433004462 PE family; Region: PE; pfam00934 478433004463 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 478433004464 hypothetical protein; Validated; Region: PRK08223 478433004465 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 478433004466 ATP binding site [chemical binding]; other site 478433004467 substrate interface [chemical binding]; other site 478433004468 hypothetical protein; Provisional; Region: PRK14851 478433004469 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 478433004470 serine O-acetyltransferase; Region: cysE; TIGR01172 478433004471 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 478433004472 trimer interface [polypeptide binding]; other site 478433004473 active site 478433004474 substrate binding site [chemical binding]; other site 478433004475 CoA binding site [chemical binding]; other site 478433004476 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 478433004477 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 478433004478 pyridoxal 5'-phosphate binding site [chemical binding]; other site 478433004479 dimer interface [polypeptide binding]; other site 478433004480 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 478433004481 catalytic residue [active] 478433004482 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 478433004483 Major Facilitator Superfamily; Region: MFS_1; pfam07690 478433004484 putative substrate translocation pore; other site 478433004485 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 478433004486 putative substrate translocation pore; other site 478433004487 malate dehydrogenase; Provisional; Region: PRK13529 478433004488 Malic enzyme, N-terminal domain; Region: malic; pfam00390 478433004489 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 478433004490 NAD(P) binding site [chemical binding]; other site 478433004491 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 478433004492 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 478433004493 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 478433004494 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 478433004495 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 478433004496 putative substrate translocation pore; other site 478433004497 PE family; Region: PE; pfam00934 478433004498 MarR family; Region: MarR; pfam01047 478433004499 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 478433004500 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 478433004501 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 478433004502 Walker A/P-loop; other site 478433004503 ATP binding site [chemical binding]; other site 478433004504 Q-loop/lid; other site 478433004505 ABC transporter signature motif; other site 478433004506 Walker B; other site 478433004507 D-loop; other site 478433004508 H-loop/switch region; other site 478433004509 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 478433004510 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 478433004511 Walker A/P-loop; other site 478433004512 ATP binding site [chemical binding]; other site 478433004513 Q-loop/lid; other site 478433004514 ABC transporter signature motif; other site 478433004515 Walker B; other site 478433004516 D-loop; other site 478433004517 H-loop/switch region; other site 478433004518 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 478433004519 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 478433004520 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 478433004521 putative DNA binding site [nucleotide binding]; other site 478433004522 putative Zn2+ binding site [ion binding]; other site 478433004523 AsnC family; Region: AsnC_trans_reg; pfam01037 478433004524 Amidinotransferase; Region: Amidinotransf; pfam02274 478433004525 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 478433004526 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 478433004527 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 478433004528 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 478433004529 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 478433004530 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 478433004531 catalytic residue [active] 478433004532 amino acid transporter; Region: 2A0306; TIGR00909 478433004533 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 478433004534 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 478433004535 Ligand Binding Site [chemical binding]; other site 478433004536 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 478433004537 Ligand Binding Site [chemical binding]; other site 478433004538 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 478433004539 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 478433004540 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 478433004541 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 478433004542 dimer interface [polypeptide binding]; other site 478433004543 conserved gate region; other site 478433004544 putative PBP binding loops; other site 478433004545 ABC-ATPase subunit interface; other site 478433004546 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 478433004547 putative PBP binding loops; other site 478433004548 ABC-ATPase subunit interface; other site 478433004549 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 478433004550 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 478433004551 Uncharacterized conserved protein [Function unknown]; Region: COG2128 478433004552 Family description; Region: UvrD_C_2; pfam13538 478433004553 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 478433004554 DNA binding residues [nucleotide binding] 478433004555 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 478433004556 DNA binding site [nucleotide binding] 478433004557 active site 478433004558 Int/Topo IB signature motif; other site 478433004559 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 478433004560 Uncharacterized conserved protein [Function unknown]; Region: COG2442 478433004561 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 478433004562 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 478433004563 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 478433004564 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 478433004565 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 478433004566 Cutinase; Region: Cutinase; pfam01083 478433004567 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 478433004568 heat shock protein 90; Provisional; Region: PRK05218 478433004569 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 478433004570 ATP binding site [chemical binding]; other site 478433004571 Mg2+ binding site [ion binding]; other site 478433004572 G-X-G motif; other site 478433004573 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 478433004574 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 478433004575 active site 478433004576 catalytic tetrad [active] 478433004577 haloalkane dehalogenase; Provisional; Region: PRK00870 478433004578 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3196 478433004579 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 478433004580 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 478433004581 pyridoxal 5'-phosphate binding site [chemical binding]; other site 478433004582 homodimer interface [polypeptide binding]; other site 478433004583 catalytic residue [active] 478433004584 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 478433004585 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 478433004586 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 478433004587 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 478433004588 active site residue [active] 478433004589 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 478433004590 active site residue [active] 478433004591 CDP-diacylglycerol pyrophosphatase [Lipid metabolism]; Region: Cdh; COG2134 478433004592 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 478433004593 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 478433004594 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 478433004595 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 478433004596 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 478433004597 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 478433004598 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 478433004599 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 478433004600 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 478433004601 Transposase; Region: HTH_Tnp_1; cl17663 478433004602 putative transposase OrfB; Reviewed; Region: PHA02517 478433004603 HTH-like domain; Region: HTH_21; pfam13276 478433004604 Integrase core domain; Region: rve; pfam00665 478433004605 Integrase core domain; Region: rve_3; pfam13683 478433004606 Transcriptional regulator [Transcription]; Region: LysR; COG0583 478433004607 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 478433004608 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 478433004609 dimerization interface [polypeptide binding]; other site 478433004610 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 478433004611 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 478433004612 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 478433004613 FAD binding domain; Region: FAD_binding_4; pfam01565 478433004614 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial protein Rv2277c and similar proteins; Region: GDPD_Rv2277c_like; cd08580 478433004615 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 478433004616 putative active site [active] 478433004617 catalytic site [active] 478433004618 putative metal binding site [ion binding]; other site 478433004619 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 478433004620 Cytochrome P450; Region: p450; cl12078 478433004621 Domain of unknown function (DUF202); Region: DUF202; pfam02656 478433004622 Predicted membrane protein [Function unknown]; Region: COG2149 478433004623 Protein of unknown function (DUF2695); Region: DUF2695; pfam10905 478433004624 Septum formation; Region: Septum_form; pfam13845 478433004625 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 478433004626 Cytochrome P450; Region: p450; cl12078 478433004627 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 478433004628 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 478433004629 Cytochrome P450; Region: p450; cl12078 478433004630 Major Facilitator Superfamily; Region: MFS_1; pfam07690 478433004631 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 478433004632 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 478433004633 nucleotide binding site [chemical binding]; other site 478433004634 short chain dehydrogenase; Provisional; Region: PRK05854 478433004635 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 478433004636 putative NAD(P) binding site [chemical binding]; other site 478433004637 active site 478433004638 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 478433004639 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 478433004640 putative active site [active] 478433004641 catalytic triad [active] 478433004642 putative dimer interface [polypeptide binding]; other site 478433004643 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 478433004644 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 478433004645 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 478433004646 NAD binding site [chemical binding]; other site 478433004647 catalytic Zn binding site [ion binding]; other site 478433004648 substrate binding site [chemical binding]; other site 478433004649 structural Zn binding site [ion binding]; other site 478433004650 Methyltransferase domain; Region: Methyltransf_31; pfam13847 478433004651 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478433004652 S-adenosylmethionine binding site [chemical binding]; other site 478433004653 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 478433004654 Beta-lactamase; Region: Beta-lactamase; pfam00144 478433004655 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 478433004656 diacylglycerol kinase; Reviewed; Region: PRK11914 478433004657 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 478433004658 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 478433004659 FAD binding domain; Region: FAD_binding_4; pfam01565 478433004660 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 478433004661 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478433004662 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 478433004663 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 478433004664 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 478433004665 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 478433004666 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 478433004667 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 478433004668 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 478433004669 dimer interface [polypeptide binding]; other site 478433004670 active site 478433004671 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 478433004672 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 478433004673 dimer interface [polypeptide binding]; other site 478433004674 active site 478433004675 acyl carrier protein; Provisional; Region: acpP; PRK00982 478433004676 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 478433004677 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 478433004678 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 478433004679 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 478433004680 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 478433004681 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 478433004682 dimer interface [polypeptide binding]; other site 478433004683 TPP-binding site [chemical binding]; other site 478433004684 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 478433004685 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 478433004686 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 478433004687 dimer interface [polypeptide binding]; other site 478433004688 catalytic triad [active] 478433004689 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 478433004690 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 478433004691 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 478433004692 Low molecular weight phosphatase family; Region: LMWPc; cd00115 478433004693 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 478433004694 active site 478433004695 phosphoglycolate phosphatase; Provisional; Region: PRK13222 478433004696 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 478433004697 active site 478433004698 motif I; other site 478433004699 motif II; other site 478433004700 PIN domain nuclease, a component of toxin-antitoxin system (PIN domain) [Signal transduction mechanisms]; Region: COG3744 478433004701 hypothetical protein; Provisional; Region: PRK07908 478433004702 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 478433004703 pyridoxal 5'-phosphate binding site [chemical binding]; other site 478433004704 homodimer interface [polypeptide binding]; other site 478433004705 catalytic residue [active] 478433004706 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 478433004707 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 478433004708 Uncharacterized conserved protein [Function unknown]; Region: COG0327 478433004709 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 478433004710 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 478433004711 Putative zinc ribbon domain; Region: DUF164; pfam02591 478433004712 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 478433004713 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 478433004714 RNA/DNA hybrid binding site [nucleotide binding]; other site 478433004715 active site 478433004716 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 478433004717 catalytic core [active] 478433004718 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3826 478433004719 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 478433004720 putative active site; other site 478433004721 putative metal binding residues [ion binding]; other site 478433004722 signature motif; other site 478433004723 putative triphosphate binding site [ion binding]; other site 478433004724 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 478433004725 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 478433004726 oligomerization interface [polypeptide binding]; other site 478433004727 active site 478433004728 metal binding site [ion binding]; metal-binding site 478433004729 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 478433004730 TAP-like protein; Region: Abhydrolase_4; pfam08386 478433004731 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 478433004732 TAP-like protein; Region: Abhydrolase_4; pfam08386 478433004733 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 478433004734 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 478433004735 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 478433004736 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 478433004737 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 478433004738 metal binding triad; other site 478433004739 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 478433004740 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 478433004741 metal binding triad; other site 478433004742 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 478433004743 glutamine synthetase, type I; Region: GlnA; TIGR00653 478433004744 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 478433004745 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 478433004746 RDD family; Region: RDD; pfam06271 478433004747 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 478433004748 lipoyl synthase; Provisional; Region: PRK05481 478433004749 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 478433004750 FeS/SAM binding site; other site 478433004751 lipoate-protein ligase B; Provisional; Region: PRK14345 478433004752 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 478433004753 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 478433004754 putative NAD(P) binding site [chemical binding]; other site 478433004755 putative active site [active] 478433004756 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 478433004757 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 478433004758 E3 interaction surface; other site 478433004759 lipoyl attachment site [posttranslational modification]; other site 478433004760 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 478433004761 E3 interaction surface; other site 478433004762 lipoyl attachment site [posttranslational modification]; other site 478433004763 e3 binding domain; Region: E3_binding; pfam02817 478433004764 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 478433004765 short chain dehydrogenase; Validated; Region: PRK05855 478433004766 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 478433004767 classical (c) SDRs; Region: SDR_c; cd05233 478433004768 NAD(P) binding site [chemical binding]; other site 478433004769 active site 478433004770 multifunctional aminopeptidase A; Provisional; Region: PRK00913 478433004771 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 478433004772 interface (dimer of trimers) [polypeptide binding]; other site 478433004773 Substrate-binding/catalytic site; other site 478433004774 Zn-binding sites [ion binding]; other site 478433004775 cyclase homology domain; Region: CHD; cd07302 478433004776 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 478433004777 nucleotidyl binding site; other site 478433004778 metal binding site [ion binding]; metal-binding site 478433004779 dimer interface [polypeptide binding]; other site 478433004780 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 478433004781 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 478433004782 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 478433004783 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 478433004784 homodimer interface [polypeptide binding]; other site 478433004785 substrate-cofactor binding pocket; other site 478433004786 catalytic residue [active] 478433004787 Cobalamin-5-phosphate synthase; Region: CobS; pfam02654 478433004788 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 478433004789 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 478433004790 putative dimer interface [polypeptide binding]; other site 478433004791 active site pocket [active] 478433004792 putative cataytic base [active] 478433004793 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 478433004794 Glycerate kinase family; Region: Gly_kinase; cl00841 478433004795 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 478433004796 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 478433004797 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 478433004798 substrate binding site [chemical binding]; other site 478433004799 ATP binding site [chemical binding]; other site 478433004800 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 478433004801 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 478433004802 dimer interface [polypeptide binding]; other site 478433004803 active site 478433004804 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 478433004805 Ligand Binding Site [chemical binding]; other site 478433004806 Molecular Tunnel; other site 478433004807 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 478433004808 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 478433004809 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 478433004810 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 478433004811 Protein of unknown function (DUF2561); Region: DUF2561; pfam10812 478433004812 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 478433004813 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 478433004814 heme bH binding site [chemical binding]; other site 478433004815 intrachain domain interface; other site 478433004816 heme bL binding site [chemical binding]; other site 478433004817 interchain domain interface [polypeptide binding]; other site 478433004818 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 478433004819 Qo binding site; other site 478433004820 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 478433004821 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 478433004822 iron-sulfur cluster [ion binding]; other site 478433004823 [2Fe-2S] cluster binding site [ion binding]; other site 478433004824 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 478433004825 Cytochrome c; Region: Cytochrom_C; pfam00034 478433004826 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 478433004827 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 478433004828 Subunit I/III interface [polypeptide binding]; other site 478433004829 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 478433004830 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 478433004831 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 478433004832 hypothetical protein; Validated; Region: PRK07883 478433004833 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 478433004834 active site 478433004835 catalytic site [active] 478433004836 substrate binding site [chemical binding]; other site 478433004837 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 478433004838 GIY-YIG motif/motif A; other site 478433004839 active site 478433004840 catalytic site [active] 478433004841 putative DNA binding site [nucleotide binding]; other site 478433004842 metal binding site [ion binding]; metal-binding site 478433004843 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 478433004844 NlpC/P60 family; Region: NLPC_P60; pfam00877 478433004845 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 478433004846 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 478433004847 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 478433004848 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 478433004849 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 478433004850 acyl-activating enzyme (AAE) consensus motif; other site 478433004851 putative AMP binding site [chemical binding]; other site 478433004852 putative active site [active] 478433004853 putative CoA binding site [chemical binding]; other site 478433004854 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 478433004855 putative hydrophobic ligand binding site [chemical binding]; other site 478433004856 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 478433004857 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 478433004858 DTAP/Switch II; other site 478433004859 Switch I; other site 478433004860 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 478433004861 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 478433004862 putative acyl-acceptor binding pocket; other site 478433004863 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 478433004864 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; COG3200 478433004865 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 478433004866 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 478433004867 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 478433004868 Catalytic domain of Protein Kinases; Region: PKc; cd00180 478433004869 active site 478433004870 ATP binding site [chemical binding]; other site 478433004871 substrate binding site [chemical binding]; other site 478433004872 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 478433004873 substrate binding site [chemical binding]; other site 478433004874 activation loop (A-loop); other site 478433004875 activation loop (A-loop); other site 478433004876 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 478433004877 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 478433004878 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 478433004879 substrate binding pocket [chemical binding]; other site 478433004880 chain length determination region; other site 478433004881 substrate-Mg2+ binding site; other site 478433004882 catalytic residues [active] 478433004883 aspartate-rich region 1; other site 478433004884 active site lid residues [active] 478433004885 aspartate-rich region 2; other site 478433004886 Protein of unknown function (DUF3153); Region: DUF3153; pfam11353 478433004887 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 478433004888 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 478433004889 MraZ protein; Region: MraZ; pfam02381 478433004890 MraZ protein; Region: MraZ; pfam02381 478433004891 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 478433004892 MraW methylase family; Region: Methyltransf_5; pfam01795 478433004893 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 478433004894 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 478433004895 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 478433004896 PE family; Region: PE; pfam00934 478433004897 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 478433004898 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 478433004899 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 478433004900 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 478433004901 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 478433004902 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 478433004903 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 478433004904 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 478433004905 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 478433004906 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 478433004907 Mg++ binding site [ion binding]; other site 478433004908 putative catalytic motif [active] 478433004909 putative substrate binding site [chemical binding]; other site 478433004910 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03369 478433004911 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 478433004912 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 478433004913 cell division protein FtsW; Region: ftsW; TIGR02614 478433004914 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 478433004915 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Region: murG; TIGR01133 478433004916 active site 478433004917 homodimer interface [polypeptide binding]; other site 478433004918 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 478433004919 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 478433004920 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 478433004921 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 478433004922 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 478433004923 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 478433004924 Cell division protein FtsQ; Region: FtsQ; pfam03799 478433004925 cell division protein FtsZ; Validated; Region: PRK09330 478433004926 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 478433004927 nucleotide binding site [chemical binding]; other site 478433004928 SulA interaction site; other site 478433004929 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 478433004930 uncharacterized protein, YfiH family; Region: TIGR00726 478433004931 Predicted enzyme with a TIM-barrel fold [General function prediction only]; Region: COG0325 478433004932 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 478433004933 catalytic residue [active] 478433004934 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 478433004935 Predicted integral membrane protein [Function unknown]; Region: COG0762 478433004936 DivIVA domain; Region: DivI1A_domain; TIGR03544 478433004937 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 478433004938 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 478433004939 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 478433004940 active site 478433004941 putative addiction module component, TIGR02574 family; Region: stabl_TIGR02574 478433004942 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483 478433004943 hypothetical protein; Provisional; Region: PRK07906 478433004944 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 478433004945 putative metal binding site [ion binding]; other site 478433004946 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 478433004947 substrate binding site [chemical binding]; other site 478433004948 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 478433004949 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 478433004950 quinone interaction residues [chemical binding]; other site 478433004951 active site 478433004952 catalytic residues [active] 478433004953 FMN binding site [chemical binding]; other site 478433004954 substrate binding site [chemical binding]; other site 478433004955 undecaprenyl-diphosphatase UppP; Region: undec_PP_bacA; TIGR00753 478433004956 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 478433004957 catalytic core [active] 478433004958 conserved hypothetical protein; Region: TIGR03847 478433004959 conserved hypothetical protein; Region: TIGR03843 478433004960 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 478433004961 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 478433004962 active site 478433004963 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 478433004964 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 478433004965 active site 478433004966 HIGH motif; other site 478433004967 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 478433004968 active site 478433004969 KMSKS motif; other site 478433004970 Anticodon-binding domain of cysteinyl tRNA synthetases and domain found in MshC; Region: Anticodon_Ia_Cys_like; cd07955 478433004971 putative tRNA binding surface [nucleotide binding]; other site 478433004972 short chain dehydrogenase; Provisional; Region: PRK05872 478433004973 classical (c) SDRs; Region: SDR_c; cd05233 478433004974 NAD(P) binding site [chemical binding]; other site 478433004975 active site 478433004976 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 478433004977 PAC2 family; Region: PAC2; pfam09754 478433004978 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 478433004979 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 478433004980 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 478433004981 substrate binding pocket [chemical binding]; other site 478433004982 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 478433004983 B12 binding site [chemical binding]; other site 478433004984 cobalt ligand [ion binding]; other site 478433004985 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 478433004986 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478433004987 PPE family; Region: PPE; pfam00823 478433004988 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 478433004989 homodimer interface [polypeptide binding]; other site 478433004990 putative metal binding site [ion binding]; other site 478433004991 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 478433004992 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 478433004993 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 478433004994 Predicted membrane protein [Function unknown]; Region: COG3918 478433004995 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 478433004996 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 478433004997 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478433004998 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1550 478433004999 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 478433005000 proteasome ATPase; Region: pup_AAA; TIGR03689 478433005001 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 478433005002 Walker A motif; other site 478433005003 ATP binding site [chemical binding]; other site 478433005004 Walker B motif; other site 478433005005 arginine finger; other site 478433005006 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 478433005007 Pup-like protein; Region: Pup; pfam05639 478433005008 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 478433005009 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 478433005010 active site 478433005011 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 478433005012 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 478433005013 active site 478433005014 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478433005015 PPE family; Region: PPE; pfam00823 478433005016 PE family; Region: PE; pfam00934 478433005017 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 478433005018 Transposase; Region: HTH_Tnp_1; cl17663 478433005019 putative transposase OrfB; Reviewed; Region: PHA02517 478433005020 HTH-like domain; Region: HTH_21; pfam13276 478433005021 Integrase core domain; Region: rve; pfam00665 478433005022 Integrase core domain; Region: rve_3; pfam13683 478433005023 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 478433005024 putative active site [active] 478433005025 Uncharacterized conserved protein [Function unknown]; Region: COG4279 478433005026 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 478433005027 SNF2 Helicase protein; Region: DUF3670; pfam12419 478433005028 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 478433005029 ATP binding site [chemical binding]; other site 478433005030 putative Mg++ binding site [ion binding]; other site 478433005031 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 478433005032 nucleotide binding region [chemical binding]; other site 478433005033 ATP-binding site [chemical binding]; other site 478433005034 Domain of unknown function (DUF222); Region: DUF222; pfam02720 478433005035 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 478433005036 active site 478433005037 PE family; Region: PE; pfam00934 478433005038 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 478433005039 Predicted transcriptional regulator [Transcription]; Region: COG2378 478433005040 WYL domain; Region: WYL; pfam13280 478433005041 Predicted transcriptional regulator [Transcription]; Region: COG2378 478433005042 WYL domain; Region: WYL; pfam13280 478433005043 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 478433005044 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 478433005045 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 478433005046 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 478433005047 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 478433005048 ATP binding site [chemical binding]; other site 478433005049 putative Mg++ binding site [ion binding]; other site 478433005050 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 478433005051 nucleotide binding region [chemical binding]; other site 478433005052 ATP-binding site [chemical binding]; other site 478433005053 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 478433005054 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 478433005055 5'-3' exonuclease, N-terminal resolvase-like domain; Region: 5_3_exonuc_N; pfam02739 478433005056 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 478433005057 active site 478433005058 metal binding site 1 [ion binding]; metal-binding site 478433005059 putative 5' ssDNA interaction site; other site 478433005060 metal binding site 3; metal-binding site 478433005061 metal binding site 2 [ion binding]; metal-binding site 478433005062 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 478433005063 putative DNA binding site [nucleotide binding]; other site 478433005064 putative metal binding site [ion binding]; other site 478433005065 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 478433005066 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 478433005067 active site 478433005068 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 478433005069 Catalytic domain of Protein Kinases; Region: PKc; cd00180 478433005070 active site 478433005071 ATP binding site [chemical binding]; other site 478433005072 substrate binding site [chemical binding]; other site 478433005073 activation loop (A-loop); other site 478433005074 PknH-like extracellular domain; Region: PknH_C; pfam14032 478433005075 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 478433005076 Catalytic domain of uncharacterized Mycobacterium tuberculosis Rv2075c-like proteins; Region: PI-PLCc_Rv2075c_like; cd08590 478433005077 putative active site [active] 478433005078 catalytic site [active] 478433005079 putative metal binding site [ion binding]; other site 478433005080 C-type lectin (CTL)/C-type lectin-like (CTLD) domain; Region: CLECT; cl02432 478433005081 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 478433005082 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 478433005083 NAD(P) binding site [chemical binding]; other site 478433005084 active site 478433005085 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 478433005086 active site 478433005087 putative homodimer interface [polypeptide binding]; other site 478433005088 SAM binding site [chemical binding]; other site 478433005089 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 478433005090 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 478433005091 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 478433005092 active site 478433005093 SAM binding site [chemical binding]; other site 478433005094 homodimer interface [polypeptide binding]; other site 478433005095 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 478433005096 precorrin-6x reductase; Region: precor6x_red; TIGR00715 478433005097 RNA polymerase sigma factor SigC; Reviewed; Region: PRK09649 478433005098 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 478433005099 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 478433005100 DNA binding residues [nucleotide binding] 478433005101 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 478433005102 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 478433005103 Methyltransferase domain; Region: Methyltransf_31; pfam13847 478433005104 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478433005105 S-adenosylmethionine binding site [chemical binding]; other site 478433005106 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 478433005107 active site 478433005108 SAM binding site [chemical binding]; other site 478433005109 homodimer interface [polypeptide binding]; other site 478433005110 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 478433005111 active site 478433005112 SAM binding site [chemical binding]; other site 478433005113 homodimer interface [polypeptide binding]; other site 478433005114 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 478433005115 Precorrin-8X methylmutase; Region: CbiC; pfam02570 478433005116 precorrin-3B synthase; Region: CobG; TIGR02435 478433005117 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 478433005118 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 478433005119 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 478433005120 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 478433005121 PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666 478433005122 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 478433005123 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 478433005124 intersubunit interface [polypeptide binding]; other site 478433005125 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 478433005126 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 478433005127 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 478433005128 30S ribosomal protein S18; Provisional; Region: PRK13401 478433005129 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 478433005130 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 478433005131 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 478433005132 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 478433005133 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 478433005134 active site 478433005135 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 478433005136 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 478433005137 putative active site [active] 478433005138 catalytic triad [active] 478433005139 putative dimer interface [polypeptide binding]; other site 478433005140 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 478433005141 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 478433005142 Ligand binding site; other site 478433005143 Putative Catalytic site; other site 478433005144 DXD motif; other site 478433005145 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 478433005146 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 478433005147 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 478433005148 active site 478433005149 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 478433005150 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 478433005151 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 478433005152 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 478433005153 Enoylreductase; Region: PKS_ER; smart00829 478433005154 NAD(P) binding site [chemical binding]; other site 478433005155 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 478433005156 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 478433005157 putative NADP binding site [chemical binding]; other site 478433005158 active site 478433005159 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 478433005160 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 478433005161 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 478433005162 active site 478433005163 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 478433005164 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 478433005165 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 478433005166 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 478433005167 Enoylreductase; Region: PKS_ER; smart00829 478433005168 NAD(P) binding site [chemical binding]; other site 478433005169 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 478433005170 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 478433005171 putative NADP binding site [chemical binding]; other site 478433005172 active site 478433005173 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 478433005174 hypothetical protein; Provisional; Region: PRK05865 478433005175 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 478433005176 NAD(P) binding site [chemical binding]; other site 478433005177 active site 478433005178 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 478433005179 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 478433005180 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 478433005181 substrate binding pocket [chemical binding]; other site 478433005182 catalytic triad [active] 478433005183 Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861 478433005184 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 478433005185 Isochorismatase family; Region: Isochorismatase; pfam00857 478433005186 catalytic triad [active] 478433005187 metal binding site [ion binding]; metal-binding site 478433005188 conserved cis-peptide bond; other site 478433005189 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 478433005190 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 478433005191 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 478433005192 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 478433005193 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 478433005194 dimer interface [polypeptide binding]; other site 478433005195 conserved gate region; other site 478433005196 putative PBP binding loops; other site 478433005197 ABC-ATPase subunit interface; other site 478433005198 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 478433005199 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 478433005200 dimer interface [polypeptide binding]; other site 478433005201 conserved gate region; other site 478433005202 putative PBP binding loops; other site 478433005203 ABC-ATPase subunit interface; other site 478433005204 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 478433005205 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 478433005206 Walker A/P-loop; other site 478433005207 ATP binding site [chemical binding]; other site 478433005208 Q-loop/lid; other site 478433005209 ABC transporter signature motif; other site 478433005210 Walker B; other site 478433005211 D-loop; other site 478433005212 H-loop/switch region; other site 478433005213 TOBE domain; Region: TOBE_2; pfam08402 478433005214 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 478433005215 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 478433005216 nucleophile elbow; other site 478433005217 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 478433005218 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 478433005219 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 478433005220 MDMPI C-terminal domain; Region: MDMPI_C; pfam07398 478433005221 Ligand-binding SRPBCC domain of Micromonospora echinospora CalC and related proteins; Region: SRPBCC_CalC; cd08891 478433005222 putative hydrophobic ligand binding site [chemical binding]; other site 478433005223 CLM binding site; other site 478433005224 L1 loop; other site 478433005225 DNA binding site [nucleotide binding] 478433005226 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 478433005227 putative DNA binding site [nucleotide binding]; other site 478433005228 dimerization interface [polypeptide binding]; other site 478433005229 putative Zn2+ binding site [ion binding]; other site 478433005230 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 478433005231 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 478433005232 dimer interface [polypeptide binding]; other site 478433005233 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 478433005234 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 478433005235 putative dimer interface [polypeptide binding]; other site 478433005236 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 478433005237 active site 478433005238 Erythromycin esterase homolog [General function prediction only]; Region: COG2312 478433005239 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 478433005240 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 478433005241 putative substrate binding site [chemical binding]; other site 478433005242 putative ATP binding site [chemical binding]; other site 478433005243 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 478433005244 Ligand Binding Site [chemical binding]; other site 478433005245 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 478433005246 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 478433005247 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 478433005248 Histidine kinase; Region: HisKA_3; pfam07730 478433005249 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 478433005250 Ligand Binding Site [chemical binding]; other site 478433005251 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 478433005252 Ligand Binding Site [chemical binding]; other site 478433005253 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 478433005254 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 478433005255 Predicted helicase [General function prediction only]; Region: COG4889 478433005256 Restriction endonuclease; Region: Mrr_cat_2; pfam13156 478433005257 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 478433005258 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 478433005259 ATP binding site [chemical binding]; other site 478433005260 putative Mg++ binding site [ion binding]; other site 478433005261 Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271 478433005262 ATP-binding site [chemical binding]; other site 478433005263 Methyltransferase domain; Region: Methyltransf_26; pfam13659 478433005264 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4683 478433005265 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 478433005266 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 478433005267 non-specific DNA binding site [nucleotide binding]; other site 478433005268 salt bridge; other site 478433005269 sequence-specific DNA binding site [nucleotide binding]; other site 478433005270 Predicted helicase [General function prediction only]; Region: COG4889 478433005271 Uncharacterized conserved protein [Function unknown]; Region: COG2442 478433005272 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 478433005273 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 478433005274 non-specific DNA binding site [nucleotide binding]; other site 478433005275 salt bridge; other site 478433005276 sequence-specific DNA binding site [nucleotide binding]; other site 478433005277 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 478433005278 Domain of unknown function (DUF222); Region: DUF222; pfam02720 478433005279 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 478433005280 active site 478433005281 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 478433005282 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 478433005283 Transposase; Region: DEDD_Tnp_IS110; pfam01548 478433005284 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 478433005285 Phage envelope protein [General function prediction only]; Region: COG5562 478433005286 Transcriptional regulators [Transcription]; Region: MarR; COG1846 478433005287 MarR family; Region: MarR_2; pfam12802 478433005288 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 478433005289 putative active site [active] 478433005290 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 478433005291 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 478433005292 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 478433005293 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 478433005294 Walker A motif; other site 478433005295 ATP binding site [chemical binding]; other site 478433005296 Walker B motif; other site 478433005297 arginine finger; other site 478433005298 Ferredoxin [Energy production and conversion]; Region: COG1146 478433005299 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 478433005300 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 478433005301 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 478433005302 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 478433005303 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 478433005304 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 478433005305 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 478433005306 Universal stress protein family; Region: Usp; pfam00582 478433005307 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 478433005308 Ligand Binding Site [chemical binding]; other site 478433005309 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 478433005310 Predicted kinase [General function prediction only]; Region: COG0645 478433005311 AAA domain; Region: AAA_17; pfam13207 478433005312 Methyltransferase domain; Region: Methyltransf_23; pfam13489 478433005313 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478433005314 S-adenosylmethionine binding site [chemical binding]; other site 478433005315 3beta17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 3beta-17beta-HSD_like_SDR_c; cd05341 478433005316 homotetramer interface [polypeptide binding]; other site 478433005317 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 478433005318 NAD binding site [chemical binding]; other site 478433005319 homodimer interface [polypeptide binding]; other site 478433005320 active site 478433005321 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 478433005322 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 478433005323 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 478433005324 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 478433005325 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 478433005326 tetramer interface [polypeptide binding]; other site 478433005327 active site 478433005328 Mg2+/Mn2+ binding site [ion binding]; other site 478433005329 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 478433005330 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 478433005331 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 478433005332 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 478433005333 Soluble P-type ATPase [General function prediction only]; Region: COG4087 478433005334 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 478433005335 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 478433005336 Ligand Binding Site [chemical binding]; other site 478433005337 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 478433005338 Ligand Binding Site [chemical binding]; other site 478433005339 Hemerythrin-like domain; Region: Hr-like; cd12108 478433005340 Fe binding site [ion binding]; other site 478433005341 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 478433005342 dimerization interface [polypeptide binding]; other site 478433005343 putative DNA binding site [nucleotide binding]; other site 478433005344 putative Zn2+ binding site [ion binding]; other site 478433005345 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 478433005346 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 478433005347 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 478433005348 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 478433005349 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 478433005350 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 478433005351 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 478433005352 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 478433005353 Uncharacterized conserved protein [Function unknown]; Region: COG5654 478433005354 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478433005355 S-adenosylmethionine binding site [chemical binding]; other site 478433005356 Cellulose binding domain; Region: CBM_2; pfam00553 478433005357 Lysine efflux permease [General function prediction only]; Region: COG1279 478433005358 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 478433005359 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 478433005360 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 478433005361 dimerization interface [polypeptide binding]; other site 478433005362 Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594 478433005363 Cutinase; Region: Cutinase; pfam01083 478433005364 PE family; Region: PE; pfam00934 478433005365 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4423 478433005366 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 478433005367 putative active site [active] 478433005368 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 478433005369 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 478433005370 dimer interface [polypeptide binding]; other site 478433005371 putative radical transfer pathway; other site 478433005372 diiron center [ion binding]; other site 478433005373 tyrosyl radical; other site 478433005374 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 478433005375 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 478433005376 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478433005377 S-adenosylmethionine binding site [chemical binding]; other site 478433005378 Peptidase family M48; Region: Peptidase_M48; pfam01435 478433005379 YacP-like NYN domain; Region: NYN_YacP; cl01491 478433005380 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 478433005381 Protein of unknown function (DUF732); Region: DUF732; pfam05305 478433005382 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 478433005383 mce related protein; Region: MCE; pfam02470 478433005384 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 478433005385 mce related protein; Region: MCE; pfam02470 478433005386 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 478433005387 mce related protein; Region: MCE; pfam02470 478433005388 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 478433005389 mce related protein; Region: MCE; pfam02470 478433005390 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 478433005391 mce related protein; Region: MCE; pfam02470 478433005392 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 478433005393 mce related protein; Region: MCE; pfam02470 478433005394 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 478433005395 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 478433005396 Permease; Region: Permease; pfam02405 478433005397 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 478433005398 Permease; Region: Permease; pfam02405 478433005399 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 478433005400 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478433005401 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 478433005402 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478433005403 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 478433005404 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 478433005405 putative active site [active] 478433005406 Uncharacterized protein family (UPF0156); Region: RHH_2; pfam03693 478433005407 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 478433005408 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 478433005409 non-specific DNA binding site [nucleotide binding]; other site 478433005410 salt bridge; other site 478433005411 sequence-specific DNA binding site [nucleotide binding]; other site 478433005412 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 478433005413 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: VapC; COG1487 478433005414 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 478433005415 Domain of unknown function (DUF222); Region: DUF222; pfam02720 478433005416 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 478433005417 active site 478433005418 SEC-C motif; Region: SEC-C; pfam02810 478433005419 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 478433005420 classical (c) SDR, subgroup 12; Region: SDR_c12; cd08944 478433005421 putative NAD(P) binding site [chemical binding]; other site 478433005422 active site 478433005423 homodimer interface [polypeptide binding]; other site 478433005424 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 478433005425 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 478433005426 GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807 478433005427 dimerization interface [polypeptide binding]; other site 478433005428 active site 478433005429 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 478433005430 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 478433005431 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 478433005432 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 478433005433 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 478433005434 catalytic loop [active] 478433005435 iron binding site [ion binding]; other site 478433005436 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 478433005437 FAD binding pocket [chemical binding]; other site 478433005438 FAD binding motif [chemical binding]; other site 478433005439 phosphate binding motif [ion binding]; other site 478433005440 beta-alpha-beta structure motif; other site 478433005441 NAD binding pocket [chemical binding]; other site 478433005442 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 478433005443 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 478433005444 enoyl-CoA hydratase; Provisional; Region: PRK08290 478433005445 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 478433005446 substrate binding site [chemical binding]; other site 478433005447 oxyanion hole (OAH) forming residues; other site 478433005448 trimer interface [polypeptide binding]; other site 478433005449 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 478433005450 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 478433005451 FAD binding site [chemical binding]; other site 478433005452 substrate binding site [chemical binding]; other site 478433005453 catalytic base [active] 478433005454 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 478433005455 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 478433005456 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 478433005457 active site 478433005458 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 478433005459 dimer interface [polypeptide binding]; other site 478433005460 catalytic triad [active] 478433005461 peroxidatic and resolving cysteines [active] 478433005462 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 478433005463 conserved cys residue [active] 478433005464 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 478433005465 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 478433005466 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 478433005467 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 478433005468 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 478433005469 TIGR03085 family protein; Region: TIGR03085 478433005470 short chain dehydrogenase; Provisional; Region: PRK05867 478433005471 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 478433005472 NAD(P) binding site [chemical binding]; other site 478433005473 active site 478433005474 Uncharacterized conserved protein [Function unknown]; Region: COG3361 478433005475 Domain of unknown function (DUF1942); Region: DUF1942; pfam09167 478433005476 putative fatty-acid--CoA ligase; Provisional; Region: PRK12476 478433005477 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 478433005478 acyl-activating enzyme (AAE) consensus motif; other site 478433005479 active site 478433005480 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 478433005481 Beta-lactamase; Region: Beta-lactamase; pfam00144 478433005482 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 478433005483 Beta-lactamase; Region: Beta-lactamase; pfam00144 478433005484 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 478433005485 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 478433005486 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 478433005487 putative acyl-acceptor binding pocket; other site 478433005488 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 478433005489 putative hydrophobic ligand binding site [chemical binding]; other site 478433005490 protein interface [polypeptide binding]; other site 478433005491 gate; other site 478433005492 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478433005493 PPE family; Region: PPE; pfam00823 478433005494 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478433005495 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478433005496 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478433005497 PPE family; Region: PPE; pfam00823 478433005498 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478433005499 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478433005500 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478433005501 Isocitrate lyase [Energy production and conversion]; Region: AceA; COG2224 478433005502 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 478433005503 tetramer interface [polypeptide binding]; other site 478433005504 active site 478433005505 Mg2+/Mn2+ binding site [ion binding]; other site 478433005506 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 478433005507 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 478433005508 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR3; cd08275 478433005509 putative NAD(P) binding site [chemical binding]; other site 478433005510 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 478433005511 substrate binding site [chemical binding]; other site 478433005512 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 478433005513 substrate binding site [chemical binding]; other site 478433005514 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 478433005515 metal binding site 2 [ion binding]; metal-binding site 478433005516 putative DNA binding helix; other site 478433005517 metal binding site 1 [ion binding]; metal-binding site 478433005518 dimer interface [polypeptide binding]; other site 478433005519 structural Zn2+ binding site [ion binding]; other site 478433005520 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 478433005521 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 478433005522 dimer interface [polypeptide binding]; other site 478433005523 active site 478433005524 heme binding site [chemical binding]; other site 478433005525 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 478433005526 Domain of unknown function (DUF4262); Region: DUF4262; pfam14081 478433005527 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 478433005528 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 478433005529 anti sigma factor interaction site; other site 478433005530 regulatory phosphorylation site [posttranslational modification]; other site 478433005531 Predicted membrane protein [Function unknown]; Region: COG1950 478433005532 putative sialic acid transporter; Region: 2A0112; TIGR00891 478433005533 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 478433005534 putative substrate translocation pore; other site 478433005535 competence damage-inducible protein A; Provisional; Region: PRK00549 478433005536 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 478433005537 putative MPT binding site; other site 478433005538 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 478433005539 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 478433005540 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 478433005541 cyclase homology domain; Region: CHD; cd07302 478433005542 nucleotidyl binding site; other site 478433005543 metal binding site [ion binding]; metal-binding site 478433005544 dimer interface [polypeptide binding]; other site 478433005545 Macro domain, Unknown family 2. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_2; cd03330 478433005546 putative ADP-ribose binding site [chemical binding]; other site 478433005547 Domain of unknown function DUF77; Region: DUF77; pfam01910 478433005548 D-tyrosyl-tRNA(Tyr) deacylase; Provisional; Region: PRK05273 478433005549 putative active site [active] 478433005550 dimerization interface [polypeptide binding]; other site 478433005551 putative tRNAtyr binding site [nucleotide binding]; other site 478433005552 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 478433005553 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 478433005554 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 2; Region: FDH_like_2; cd08284 478433005555 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 478433005556 catalytic Zn binding site [ion binding]; other site 478433005557 NAD(P) binding site [chemical binding]; other site 478433005558 structural Zn binding site [ion binding]; other site 478433005559 Nitronate monooxygenase; Region: NMO; pfam03060 478433005560 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 478433005561 FMN binding site [chemical binding]; other site 478433005562 substrate binding site [chemical binding]; other site 478433005563 putative catalytic residue [active] 478433005564 Uncharacterized conserved protein [Function unknown]; Region: COG2353 478433005565 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 478433005566 Leucine carboxyl methyltransferase; Region: LCM; cl01306 478433005567 Leucine carboxyl methyltransferase; Region: LCM; cl01306 478433005568 Putative esterase; Region: Esterase; pfam00756 478433005569 chorismate mutase; Provisional; Region: PRK09269 478433005570 chorismate mutase, putative; Region: CM_mono2; TIGR01806 478433005571 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 478433005572 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 478433005573 hydrophobic ligand binding site; other site 478433005574 short chain dehydrogenase; Provisional; Region: PRK08267 478433005575 classical (c) SDR, subgroup 9; Region: SDR_c9; cd08931 478433005576 putative NAD(P) binding site [chemical binding]; other site 478433005577 active site 478433005578 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 478433005579 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 478433005580 Cytochrome P450; Region: p450; cl12078 478433005581 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 478433005582 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 478433005583 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 478433005584 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 478433005585 Major Facilitator Superfamily; Region: MFS_1; pfam07690 478433005586 putative substrate translocation pore; other site 478433005587 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 478433005588 putative substrate translocation pore; other site 478433005589 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cl00333 478433005590 23S rRNA interface [nucleotide binding]; other site 478433005591 L3 interface [polypeptide binding]; other site 478433005592 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 478433005593 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 478433005594 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 478433005595 heme binding site [chemical binding]; other site 478433005596 ferroxidase pore; other site 478433005597 ferroxidase diiron center [ion binding]; other site 478433005598 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 478433005599 Uncharacterized conserved protein [Function unknown]; Region: COG5579 478433005600 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 478433005601 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 478433005602 active site 478433005603 substrate binding site [chemical binding]; other site 478433005604 FMN binding site [chemical binding]; other site 478433005605 putative catalytic residues [active] 478433005606 Domain of unknown function (DUF385); Region: DUF385; pfam04075 478433005607 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 478433005608 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 478433005609 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 478433005610 hypothetical protein; Provisional; Region: PRK12320 478433005611 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 478433005612 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 478433005613 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 478433005614 active site 478433005615 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 478433005616 CoA-transferase family III; Region: CoA_transf_3; pfam02515 478433005617 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 478433005618 CoA-transferase family III; Region: CoA_transf_3; pfam02515 478433005619 short chain dehydrogenase; Provisional; Region: PRK07825 478433005620 classical (c) SDRs; Region: SDR_c; cd05233 478433005621 NAD(P) binding site [chemical binding]; other site 478433005622 active site 478433005623 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 478433005624 MOSC domain; Region: MOSC; pfam03473 478433005625 CAAX protease self-immunity; Region: Abi; pfam02517 478433005626 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 478433005627 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822 478433005628 putative NAD(P) binding site [chemical binding]; other site 478433005629 putative substrate binding site [chemical binding]; other site 478433005630 catalytic Zn binding site [ion binding]; other site 478433005631 structural Zn binding site [ion binding]; other site 478433005632 Predicted membrane protein [Function unknown]; Region: COG2261 478433005633 Fibronectin-attachment protein (FAP); Region: FAP; pfam07174 478433005634 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 478433005635 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 478433005636 Walker A/P-loop; other site 478433005637 ATP binding site [chemical binding]; other site 478433005638 Q-loop/lid; other site 478433005639 ABC transporter signature motif; other site 478433005640 Walker B; other site 478433005641 D-loop; other site 478433005642 H-loop/switch region; other site 478433005643 TOBE domain; Region: TOBE; pfam03459 478433005644 sulfate transport protein; Provisional; Region: cysT; CHL00187 478433005645 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 478433005646 dimer interface [polypeptide binding]; other site 478433005647 conserved gate region; other site 478433005648 putative PBP binding loops; other site 478433005649 ABC-ATPase subunit interface; other site 478433005650 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 478433005651 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 478433005652 classical (c) SDRs; Region: SDR_c; cd05233 478433005653 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 478433005654 NAD(P) binding site [chemical binding]; other site 478433005655 active site 478433005656 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 478433005657 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 478433005658 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 478433005659 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 478433005660 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 478433005661 UreD urease accessory protein; Region: UreD; cl00530 478433005662 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 478433005663 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 478433005664 UreF; Region: UreF; pfam01730 478433005665 urease subunit alpha; Reviewed; Region: ureC; PRK13206 478433005666 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 478433005667 subunit interactions [polypeptide binding]; other site 478433005668 active site 478433005669 flap region; other site 478433005670 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 478433005671 gamma-beta subunit interface [polypeptide binding]; other site 478433005672 alpha-beta subunit interface [polypeptide binding]; other site 478433005673 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 478433005674 alpha-gamma subunit interface [polypeptide binding]; other site 478433005675 beta-gamma subunit interface [polypeptide binding]; other site 478433005676 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 478433005677 CoenzymeA binding site [chemical binding]; other site 478433005678 subunit interaction site [polypeptide binding]; other site 478433005679 PHB binding site; other site 478433005680 Predicted transcriptional regulator [Transcription]; Region: COG3682 478433005681 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 478433005682 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 478433005683 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 478433005684 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 478433005685 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 478433005686 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 478433005687 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 478433005688 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 478433005689 active site 478433005690 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 478433005691 Domain of unknown function DUF21; Region: DUF21; pfam01595 478433005692 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 478433005693 Transporter associated domain; Region: CorC_HlyC; smart01091 478433005694 Domain of unknown function DUF21; Region: DUF21; pfam01595 478433005695 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 478433005696 FOG: CBS domain [General function prediction only]; Region: COG0517 478433005697 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 478433005698 putative active site [active] 478433005699 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 478433005700 active site 478433005701 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 478433005702 metal ion-dependent adhesion site (MIDAS); other site 478433005703 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 478433005704 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 478433005705 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 478433005706 haloalkane dehalogenase; Provisional; Region: PRK03204 478433005707 glycine dehydrogenase; Provisional; Region: PRK05367 478433005708 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 478433005709 pyridoxal 5'-phosphate binding site [chemical binding]; other site 478433005710 tetramer interface [polypeptide binding]; other site 478433005711 catalytic residue [active] 478433005712 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 478433005713 tetramer interface [polypeptide binding]; other site 478433005714 pyridoxal 5'-phosphate binding site [chemical binding]; other site 478433005715 catalytic residue [active] 478433005716 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 478433005717 DNA binding residues [nucleotide binding] 478433005718 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 478433005719 putative dimer interface [polypeptide binding]; other site 478433005720 Bifunctional nuclease; Region: DNase-RNase; pfam02577 478433005721 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 478433005722 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 478433005723 DNA binding residues [nucleotide binding] 478433005724 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 478433005725 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 478433005726 phosphopeptide binding site; other site 478433005727 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 478433005728 lipoyl attachment site [posttranslational modification]; other site 478433005729 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 478433005730 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 478433005731 Uncharacterized conserved protein (small basic protein) [Function unknown]; Region: Sbp; COG3856 478433005732 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 478433005733 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 478433005734 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 478433005735 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 478433005736 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 478433005737 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 478433005738 nucleotide binding region [chemical binding]; other site 478433005739 ATP-binding site [chemical binding]; other site 478433005740 hypothetical protein; Provisional; Region: PRK05858 478433005741 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 478433005742 PYR/PP interface [polypeptide binding]; other site 478433005743 dimer interface [polypeptide binding]; other site 478433005744 TPP binding site [chemical binding]; other site 478433005745 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 478433005746 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 478433005747 TPP-binding site; other site 478433005748 dimer interface [polypeptide binding]; other site 478433005749 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 478433005750 ABC transporter transmembrane region 2; Region: ABC_membrane_2; pfam06472 478433005751 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 478433005752 PE family; Region: PE; pfam00934 478433005753 hypothetical protein; Validated; Region: PRK07121 478433005754 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 478433005755 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 478433005756 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 478433005757 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 478433005758 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 478433005759 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 478433005760 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 478433005761 MgtC family; Region: MgtC; pfam02308 478433005762 Protein of unknown function (DUF732); Region: DUF732; pfam05305 478433005763 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478433005764 PPE family; Region: PPE; pfam00823 478433005765 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 478433005766 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478433005767 PPE family; Region: PPE; pfam00823 478433005768 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478433005769 PPE family; Region: PPE; pfam00823 478433005770 PE family; Region: PE; pfam00934 478433005771 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 478433005772 Transposase; Region: HTH_Tnp_1; cl17663 478433005773 putative transposase OrfB; Reviewed; Region: PHA02517 478433005774 HTH-like domain; Region: HTH_21; pfam13276 478433005775 Integrase core domain; Region: rve; pfam00665 478433005776 Integrase core domain; Region: rve_3; pfam13683 478433005777 Protein of unknown function (DUF732); Region: DUF732; pfam05305 478433005778 PE family; Region: PE; pfam00934 478433005779 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478433005780 PPE family; Region: PPE; pfam00823 478433005781 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478433005782 PPE family; Region: PPE; pfam00823 478433005783 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478433005784 PPE family; Region: PPE; pfam00823 478433005785 PE-PPE domain; Region: PE-PPE; pfam08237 478433005786 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 478433005787 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 478433005788 Walker A motif; other site 478433005789 ATP binding site [chemical binding]; other site 478433005790 Walker B motif; other site 478433005791 arginine finger; other site 478433005792 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 478433005793 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 478433005794 catalytic residues [active] 478433005795 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 478433005796 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 478433005797 active site 478433005798 catalytic residues [active] 478433005799 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 478433005800 EspG family; Region: ESX-1_EspG; pfam14011 478433005801 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 478433005802 Proteins of 100 residues with WXG; Region: WXG100; cl02005 478433005803 PE family; Region: PE; pfam00934 478433005804 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478433005805 PPE family; Region: PPE; pfam00823 478433005806 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 478433005807 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478433005808 PPE family; Region: PPE; pfam00823 478433005809 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 478433005810 PE family; Region: PE; pfam00934 478433005811 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478433005812 PPE family; Region: PPE; pfam00823 478433005813 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 478433005814 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 478433005815 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 478433005816 Cytochrome P450; Region: p450; cl12078 478433005817 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 478433005818 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 478433005819 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 478433005820 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 478433005821 Protein of unknown function (DUF690); Region: DUF690; pfam05108 478433005822 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 478433005823 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 478433005824 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362 478433005825 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 478433005826 Cytochrome P450; Region: p450; cl12078 478433005827 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 478433005828 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478433005829 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 478433005830 FAD binding domain; Region: FAD_binding_4; pfam01565 478433005831 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 478433005832 Transcriptional regulator [Transcription]; Region: IclR; COG1414 478433005833 Bacterial transcriptional regulator; Region: IclR; pfam01614 478433005834 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 478433005835 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 478433005836 FAD binding domain; Region: FAD_binding_4; pfam01565 478433005837 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 478433005838 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 478433005839 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 478433005840 metal binding site [ion binding]; metal-binding site 478433005841 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 478433005842 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813 478433005843 dimer interface [polypeptide binding]; other site 478433005844 active site 478433005845 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 478433005846 substrate binding site [chemical binding]; other site 478433005847 catalytic residue [active] 478433005848 PE family; Region: PE; pfam00934 478433005849 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 478433005850 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 478433005851 putative homotetramer interface [polypeptide binding]; other site 478433005852 putative homodimer interface [polypeptide binding]; other site 478433005853 putative allosteric switch controlling residues; other site 478433005854 putative metal binding site [ion binding]; other site 478433005855 putative homodimer-homodimer interface [polypeptide binding]; other site 478433005856 Integrase core domain; Region: rve; pfam00665 478433005857 Domain of unknown function (DUF222); Region: DUF222; pfam02720 478433005858 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 478433005859 active site 478433005860 Uncharacterized conserved protein [Function unknown]; Region: COG0393 478433005861 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 478433005862 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 478433005863 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 478433005864 Cutinase; Region: Cutinase; pfam01083 478433005865 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 478433005866 Transposase; Region: HTH_Tnp_1; cl17663 478433005867 putative transposase OrfB; Reviewed; Region: PHA02517 478433005868 HTH-like domain; Region: HTH_21; pfam13276 478433005869 Integrase core domain; Region: rve; pfam00665 478433005870 Integrase core domain; Region: rve_3; pfam13683 478433005871 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 478433005872 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478433005873 PPE family; Region: PPE; pfam00823 478433005874 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478433005875 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478433005876 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 478433005877 hypothetical protein; Provisional; Region: PRK06185 478433005878 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 478433005879 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 478433005880 acyl-CoA synthetase; Provisional; Region: PRK13388 478433005881 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 478433005882 acyl-activating enzyme (AAE) consensus motif; other site 478433005883 AMP binding site [chemical binding]; other site 478433005884 active site 478433005885 CoA binding site [chemical binding]; other site 478433005886 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 478433005887 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 478433005888 phosphopeptide binding site; other site 478433005889 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 478433005890 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 478433005891 phosphopeptide binding site; other site 478433005892 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 478433005893 The Eye Pigment Precursor Transporter (EPP) Family protein; Region: 3a01204; TIGR00955 478433005894 Walker A/P-loop; other site 478433005895 ATP binding site [chemical binding]; other site 478433005896 Q-loop/lid; other site 478433005897 ABC transporter signature motif; other site 478433005898 Walker B; other site 478433005899 D-loop; other site 478433005900 H-loop/switch region; other site 478433005901 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 478433005902 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 478433005903 Catalytic domain of Protein Kinases; Region: PKc; cd00180 478433005904 active site 478433005905 ATP binding site [chemical binding]; other site 478433005906 substrate binding site [chemical binding]; other site 478433005907 activation loop (A-loop); other site 478433005908 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 478433005909 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 478433005910 active site 478433005911 metal binding site [ion binding]; metal-binding site 478433005912 nudix motif; other site 478433005913 Protein tyrosine kinase; Region: Pkinase_Tyr; pfam07714 478433005914 Catalytic domain of Protein Kinases; Region: PKc; cd00180 478433005915 active site 478433005916 ATP binding site [chemical binding]; other site 478433005917 substrate binding site [chemical binding]; other site 478433005918 activation loop (A-loop); other site 478433005919 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 478433005920 Thioredoxin; Region: Thioredoxin_4; cl17273 478433005921 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3742 478433005922 putative active site [active] 478433005923 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4423 478433005924 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 478433005925 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 478433005926 Sulfate transporter family; Region: Sulfate_transp; pfam00916 478433005927 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 478433005928 Domain of unknown function (DUF1876); Region: DUF1876; pfam08962 478433005929 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 478433005930 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 478433005931 putative substrate translocation pore; other site 478433005932 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 478433005933 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 478433005934 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 478433005935 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 478433005936 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_1; cd09319 478433005937 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 478433005938 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_1; cd09319 478433005939 gating phenylalanine in ion channel; other site 478433005940 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes [Energy production and conversion]; Region: AceF; COG0508 478433005941 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 478433005942 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 478433005943 putative catalytic residue [active] 478433005944 succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407 478433005945 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101 478433005946 NAD(P) binding site [chemical binding]; other site 478433005947 catalytic residues [active] 478433005948 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 478433005949 Beta-lactamase; Region: Beta-lactamase; pfam00144 478433005950 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 478433005951 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 478433005952 TIGR03086 family protein; Region: TIGR03086 478433005953 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 478433005954 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 478433005955 FAD binding domain; Region: FAD_binding_4; pfam01565 478433005956 Berberine and berberine like; Region: BBE; pfam08031 478433005957 Predicted transcriptional regulators [Transcription]; Region: COG1733 478433005958 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 478433005959 dimerization interface [polypeptide binding]; other site 478433005960 putative DNA binding site [nucleotide binding]; other site 478433005961 putative Zn2+ binding site [ion binding]; other site 478433005962 Predicted transcriptional regulators [Transcription]; Region: COG1733 478433005963 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 478433005964 Beta-lactamase; Region: Beta-lactamase; pfam00144 478433005965 biotin carboxylase-like protein; Validated; Region: PRK06524 478433005966 ATP-grasp domain; Region: ATP-grasp_4; cl17255 478433005967 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 478433005968 putative active site [active] 478433005969 homotetrameric interface [polypeptide binding]; other site 478433005970 metal binding site [ion binding]; metal-binding site 478433005971 Transcriptional regulator [Transcription]; Region: IclR; COG1414 478433005972 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 478433005973 putative switch regulator; other site 478433005974 non-specific DNA interactions [nucleotide binding]; other site 478433005975 DNA binding site [nucleotide binding] 478433005976 sequence specific DNA binding site [nucleotide binding]; other site 478433005977 putative cAMP binding site [chemical binding]; other site 478433005978 Bacterial transcriptional regulator; Region: IclR; pfam01614 478433005979 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 478433005980 Cupin domain; Region: Cupin_2; cl17218 478433005981 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 478433005982 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 478433005983 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 478433005984 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 478433005985 short chain dehydrogenase; Provisional; Region: PRK07060 478433005986 classical (c) SDRs; Region: SDR_c; cd05233 478433005987 NAD(P) binding site [chemical binding]; other site 478433005988 active site 478433005989 GTP-binding protein Der; Reviewed; Region: PRK03003 478433005990 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 478433005991 GTP/Mg2+ binding site [chemical binding]; other site 478433005992 Switch I region; other site 478433005993 G2 box; other site 478433005994 Switch II region; other site 478433005995 G3 box; other site 478433005996 G4 box; other site 478433005997 G5 box; other site 478433005998 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 478433005999 G1 box; other site 478433006000 GTP/Mg2+ binding site [chemical binding]; other site 478433006001 Switch I region; other site 478433006002 G2 box; other site 478433006003 G3 box; other site 478433006004 Switch II region; other site 478433006005 G4 box; other site 478433006006 G5 box; other site 478433006007 cytidylate kinase; Provisional; Region: cmk; PRK00023 478433006008 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 478433006009 CMP-binding site; other site 478433006010 The sites determining sugar specificity; other site 478433006011 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 478433006012 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 478433006013 RNA binding surface [nucleotide binding]; other site 478433006014 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 478433006015 active site 478433006016 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 478433006017 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 478433006018 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 478433006019 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 478433006020 P-loop; other site 478433006021 Magnesium ion binding site [ion binding]; other site 478433006022 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 478433006023 Magnesium ion binding site [ion binding]; other site 478433006024 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 478433006025 Sulfate transporter family; Region: Sulfate_transp; pfam00916 478433006026 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 478433006027 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478433006028 PPE family; Region: PPE; pfam00823 478433006029 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 478433006030 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478433006031 PPE family; Region: PPE; pfam00823 478433006032 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 478433006033 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 478433006034 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 478433006035 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478433006036 S-adenosylmethionine binding site [chemical binding]; other site 478433006037 Domain of unknown function (DUF222); Region: DUF222; pfam02720 478433006038 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 478433006039 active site 478433006040 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 478433006041 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 478433006042 active site 478433006043 DNA binding site [nucleotide binding] 478433006044 Int/Topo IB signature motif; other site 478433006045 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 478433006046 dimer interface [polypeptide binding]; other site 478433006047 ADP-ribose binding site [chemical binding]; other site 478433006048 active site 478433006049 nudix motif; other site 478433006050 metal binding site [ion binding]; metal-binding site 478433006051 CTP synthetase; Validated; Region: pyrG; PRK05380 478433006052 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 478433006053 Catalytic site [active] 478433006054 active site 478433006055 UTP binding site [chemical binding]; other site 478433006056 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 478433006057 active site 478433006058 putative oxyanion hole; other site 478433006059 catalytic triad [active] 478433006060 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 478433006061 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 478433006062 Thiamine pyrophosphokinase; Region: TPK; cl08415 478433006063 Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555 478433006064 DNA repair protein RecN; Region: recN; TIGR00634 478433006065 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 478433006066 Walker A/P-loop; other site 478433006067 ATP binding site [chemical binding]; other site 478433006068 Q-loop/lid; other site 478433006069 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 478433006070 ABC transporter signature motif; other site 478433006071 Walker B; other site 478433006072 D-loop; other site 478433006073 H-loop/switch region; other site 478433006074 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 478433006075 ATP-NAD kinase; Region: NAD_kinase; pfam01513 478433006076 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 478433006077 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 478433006078 RNA binding surface [nucleotide binding]; other site 478433006079 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478433006080 S-adenosylmethionine binding site [chemical binding]; other site 478433006081 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 478433006082 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 478433006083 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 478433006084 Tetratrico peptide repeat; Region: TPR_5; pfam12688 478433006085 Protein of unknown function (DUF732); Region: DUF732; pfam05305 478433006086 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 478433006087 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 478433006088 active site 478433006089 HIGH motif; other site 478433006090 dimer interface [polypeptide binding]; other site 478433006091 KMSKS motif; other site 478433006092 S4 RNA-binding domain; Region: S4; smart00363 478433006093 RNA binding surface [nucleotide binding]; other site 478433006094 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 478433006095 active site 478433006096 DNA binding site [nucleotide binding] 478433006097 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 478433006098 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 478433006099 Walker A/P-loop; other site 478433006100 ATP binding site [chemical binding]; other site 478433006101 Q-loop/lid; other site 478433006102 ABC transporter signature motif; other site 478433006103 Walker B; other site 478433006104 D-loop; other site 478433006105 H-loop/switch region; other site 478433006106 ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025 478433006107 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 478433006108 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 478433006109 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478433006110 acyl-CoA synthetase; Validated; Region: PRK07868 478433006111 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 478433006112 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 478433006113 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 478433006114 acyl-activating enzyme (AAE) consensus motif; other site 478433006115 AMP binding site [chemical binding]; other site 478433006116 active site 478433006117 CoA binding site [chemical binding]; other site 478433006118 DivIVA protein; Region: DivIVA; pfam05103 478433006119 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 478433006120 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 478433006121 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 478433006122 FeS/SAM binding site; other site 478433006123 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 478433006124 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 478433006125 substrate binding pocket [chemical binding]; other site 478433006126 membrane-bound complex binding site; other site 478433006127 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 478433006128 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 478433006129 active site 478433006130 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 478433006131 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 478433006132 catalytic residues [active] 478433006133 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 478433006134 putative catalytic residues [active] 478433006135 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 478433006136 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 478433006137 ligand binding site [chemical binding]; other site 478433006138 flexible hinge region; other site 478433006139 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 478433006140 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 478433006141 dimerization interface [polypeptide binding]; other site 478433006142 putative DNA binding site [nucleotide binding]; other site 478433006143 putative Zn2+ binding site [ion binding]; other site 478433006144 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 478433006145 active site residue [active] 478433006146 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 478433006147 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 478433006148 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 478433006149 putative substrate translocation pore; other site 478433006150 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 478433006151 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 478433006152 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 478433006153 ABC transporter; Region: ABC_tran_2; pfam12848 478433006154 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 478433006155 Cytochrome P450; Region: p450; cl12078 478433006156 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 478433006157 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 478433006158 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 478433006159 malonyl-CoA binding site [chemical binding]; other site 478433006160 dimer interface [polypeptide binding]; other site 478433006161 active site 478433006162 product binding site; other site 478433006163 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 478433006164 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 478433006165 active site 478433006166 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 478433006167 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 478433006168 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 478433006169 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 478433006170 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 478433006171 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 478433006172 putative NADP binding site [chemical binding]; other site 478433006173 active site 478433006174 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 478433006175 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 478433006176 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 478433006177 active site 478433006178 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 478433006179 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 478433006180 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 478433006181 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 478433006182 Enoylreductase; Region: PKS_ER; smart00829 478433006183 NAD(P) binding site [chemical binding]; other site 478433006184 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 478433006185 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 478433006186 active site 478433006187 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 478433006188 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 478433006189 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 478433006190 Enoylreductase; Region: PKS_ER; smart00829 478433006191 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 478433006192 NAD(P) binding site [chemical binding]; other site 478433006193 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 478433006194 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 478433006195 putative NADP binding site [chemical binding]; other site 478433006196 active site 478433006197 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 478433006198 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 478433006199 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 478433006200 malonyl-CoA binding site [chemical binding]; other site 478433006201 dimer interface [polypeptide binding]; other site 478433006202 active site 478433006203 product binding site; other site 478433006204 argininosuccinate lyase; Provisional; Region: PRK00855 478433006205 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 478433006206 active sites [active] 478433006207 tetramer interface [polypeptide binding]; other site 478433006208 argininosuccinate synthase; Provisional; Region: PRK13820 478433006209 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 478433006210 ANP binding site [chemical binding]; other site 478433006211 Substrate Binding Site II [chemical binding]; other site 478433006212 Substrate Binding Site I [chemical binding]; other site 478433006213 arginine repressor; Provisional; Region: PRK03341 478433006214 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 478433006215 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 478433006216 ornithine carbamoyltransferase; Provisional; Region: PRK00779 478433006217 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 478433006218 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 478433006219 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 478433006220 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 478433006221 inhibitor-cofactor binding pocket; inhibition site 478433006222 pyridoxal 5'-phosphate binding site [chemical binding]; other site 478433006223 catalytic residue [active] 478433006224 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 478433006225 feedback inhibition sensing region; other site 478433006226 homohexameric interface [polypeptide binding]; other site 478433006227 nucleotide binding site [chemical binding]; other site 478433006228 N-acetyl-L-glutamate binding site [chemical binding]; other site 478433006229 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 478433006230 heterotetramer interface [polypeptide binding]; other site 478433006231 active site pocket [active] 478433006232 cleavage site 478433006233 N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850 478433006234 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 478433006235 PE family; Region: PE; pfam00934 478433006236 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 478433006237 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 478433006238 putative tRNA-binding site [nucleotide binding]; other site 478433006239 B3/4 domain; Region: B3_4; pfam03483 478433006240 tRNA synthetase B5 domain; Region: B5; smart00874 478433006241 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 478433006242 dimer interface [polypeptide binding]; other site 478433006243 motif 1; other site 478433006244 motif 3; other site 478433006245 motif 2; other site 478433006246 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 478433006247 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 478433006248 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 478433006249 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 478433006250 dimer interface [polypeptide binding]; other site 478433006251 motif 1; other site 478433006252 active site 478433006253 motif 2; other site 478433006254 motif 3; other site 478433006255 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 478433006256 cyclase homology domain; Region: CHD; cd07302 478433006257 nucleotidyl binding site; other site 478433006258 metal binding site [ion binding]; metal-binding site 478433006259 dimer interface [polypeptide binding]; other site 478433006260 PE family; Region: PE; pfam00934 478433006261 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 478433006262 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 478433006263 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 478433006264 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 478433006265 23S rRNA binding site [nucleotide binding]; other site 478433006266 L21 binding site [polypeptide binding]; other site 478433006267 L13 binding site [polypeptide binding]; other site 478433006268 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 478433006269 translation initiation factor IF-3; Region: infC; TIGR00168 478433006270 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 478433006271 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 478433006272 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 478433006273 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 478433006274 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 478433006275 dimer interface [polypeptide binding]; other site 478433006276 putative anticodon binding site; other site 478433006277 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 478433006278 motif 1; other site 478433006279 dimer interface [polypeptide binding]; other site 478433006280 active site 478433006281 motif 2; other site 478433006282 motif 3; other site 478433006283 Predicted esterase [General function prediction only]; Region: COG0627 478433006284 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 478433006285 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 478433006286 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 478433006287 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 478433006288 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 478433006289 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 478433006290 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 478433006291 Ligand Binding Site [chemical binding]; other site 478433006292 Predicted membrane protein [Function unknown]; Region: COG5305 478433006293 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 478433006294 Major Facilitator Superfamily; Region: MFS_1; pfam07690 478433006295 putative substrate translocation pore; other site 478433006296 excinuclease ABC subunit B; Provisional; Region: PRK05298 478433006297 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 478433006298 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 478433006299 nucleotide binding region [chemical binding]; other site 478433006300 ATP-binding site [chemical binding]; other site 478433006301 Ultra-violet resistance protein B; Region: UvrB; pfam12344 478433006302 UvrB/uvrC motif; Region: UVR; pfam02151 478433006303 Predicted RNA-binding protein, associated with RNAses E/G family [General function prediction only]; Region: COG2306 478433006304 dephospho-CoA kinase/protein folding accessory domain-containing protein; Provisional; Region: coaE; PRK03333 478433006305 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 478433006306 CoA-binding site [chemical binding]; other site 478433006307 ATP-binding [chemical binding]; other site 478433006308 Uncharacterized conserved protein [Function unknown]; Region: GrpB; COG2320 478433006309 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 478433006310 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 478433006311 RNA binding site [nucleotide binding]; other site 478433006312 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 478433006313 RNA binding site [nucleotide binding]; other site 478433006314 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 478433006315 RNA binding site [nucleotide binding]; other site 478433006316 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 478433006317 RNA binding site [nucleotide binding]; other site 478433006318 DNA polymerase I; Provisional; Region: PRK05755 478433006319 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 478433006320 active site 478433006321 metal binding site 1 [ion binding]; metal-binding site 478433006322 putative 5' ssDNA interaction site; other site 478433006323 metal binding site 3; metal-binding site 478433006324 metal binding site 2 [ion binding]; metal-binding site 478433006325 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 478433006326 putative DNA binding site [nucleotide binding]; other site 478433006327 putative metal binding site [ion binding]; other site 478433006328 3'-5' exonuclease; Region: 35EXOc; smart00474 478433006329 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 478433006330 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 478433006331 active site 478433006332 DNA binding site [nucleotide binding] 478433006333 catalytic site [active] 478433006334 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 478433006335 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 478433006336 DUF35 OB-fold domain; Region: DUF35; pfam01796 478433006337 lipid-transfer protein; Provisional; Region: PRK06059 478433006338 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 478433006339 active site 478433006340 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 478433006341 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 478433006342 active site 478433006343 phosphorylation site [posttranslational modification] 478433006344 intermolecular recognition site; other site 478433006345 dimerization interface [polypeptide binding]; other site 478433006346 ANTAR domain; Region: ANTAR; pfam03861 478433006347 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 478433006348 cyclase homology domain; Region: CHD; cd07302 478433006349 nucleotidyl binding site; other site 478433006350 metal binding site [ion binding]; metal-binding site 478433006351 dimer interface [polypeptide binding]; other site 478433006352 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 478433006353 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 478433006354 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 478433006355 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 478433006356 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 478433006357 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 478433006358 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 478433006359 Walker A/P-loop; other site 478433006360 ATP binding site [chemical binding]; other site 478433006361 Q-loop/lid; other site 478433006362 ABC transporter signature motif; other site 478433006363 Walker B; other site 478433006364 D-loop; other site 478433006365 H-loop/switch region; other site 478433006366 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 478433006367 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 478433006368 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 478433006369 Walker A/P-loop; other site 478433006370 Walker A/P-loop; other site 478433006371 ATP binding site [chemical binding]; other site 478433006372 ATP binding site [chemical binding]; other site 478433006373 Q-loop/lid; other site 478433006374 Uncharacterized conserved protein [Function unknown]; Region: COG2898 478433006375 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 478433006376 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 478433006377 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 478433006378 active site 478433006379 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 478433006380 catalytic triad [active] 478433006381 dimer interface [polypeptide binding]; other site 478433006382 pyruvate kinase; Provisional; Region: PRK06247 478433006383 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 478433006384 domain interfaces; other site 478433006385 active site 478433006386 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 478433006387 TM2 domain; Region: TM2; pfam05154 478433006388 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK13108 478433006389 Prolipoprotein diacylglyceryltransferase [Cell envelope biogenesis, outer membrane]; Region: Lgt; COG0682 478433006390 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 478433006391 substrate binding site [chemical binding]; other site 478433006392 active site 478433006393 catalytic residues [active] 478433006394 heterodimer interface [polypeptide binding]; other site 478433006395 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 478433006396 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 478433006397 pyridoxal 5'-phosphate binding site [chemical binding]; other site 478433006398 catalytic residue [active] 478433006399 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 478433006400 active site 478433006401 ribulose/triose binding site [chemical binding]; other site 478433006402 phosphate binding site [ion binding]; other site 478433006403 substrate (anthranilate) binding pocket [chemical binding]; other site 478433006404 product (indole) binding pocket [chemical binding]; other site 478433006405 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534 478433006406 anthranilate synthase component I; Provisional; Region: PRK13571 478433006407 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 478433006408 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 478433006409 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 478433006410 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 478433006411 catalytic triad [active] 478433006412 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 478433006413 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 478433006414 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 478433006415 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 478433006416 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 478433006417 substrate binding site [chemical binding]; other site 478433006418 glutamase interaction surface [polypeptide binding]; other site 478433006419 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 478433006420 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 478433006421 active site 478433006422 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 478433006423 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 478433006424 catalytic residues [active] 478433006425 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 478433006426 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 478433006427 putative active site [active] 478433006428 oxyanion strand; other site 478433006429 catalytic triad [active] 478433006430 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 478433006431 4-fold oligomerization interface [polypeptide binding]; other site 478433006432 putative active site pocket [active] 478433006433 metal binding residues [ion binding]; metal-binding site 478433006434 3-fold/trimer interface [polypeptide binding]; other site 478433006435 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 478433006436 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 478433006437 pyridoxal 5'-phosphate binding site [chemical binding]; other site 478433006438 homodimer interface [polypeptide binding]; other site 478433006439 catalytic residue [active] 478433006440 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 478433006441 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 478433006442 NAD binding site [chemical binding]; other site 478433006443 dimerization interface [polypeptide binding]; other site 478433006444 product binding site; other site 478433006445 substrate binding site [chemical binding]; other site 478433006446 zinc binding site [ion binding]; other site 478433006447 catalytic residues [active] 478433006448 deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026 478433006449 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478433006450 S-adenosylmethionine binding site [chemical binding]; other site 478433006451 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 478433006452 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 478433006453 dimerization interface [polypeptide binding]; other site 478433006454 active site 478433006455 L-aspartate oxidase; Provisional; Region: PRK07804 478433006456 L-aspartate oxidase; Provisional; Region: PRK06175 478433006457 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 478433006458 quinolinate synthetase; Provisional; Region: PRK09375 478433006459 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 478433006460 nudix motif; other site 478433006461 Secretory lipase; Region: LIP; pfam03583 478433006462 Protein of unknown function (DUF2567); Region: DUF2567; pfam10821 478433006463 biotin synthase; Validated; Region: PRK06256 478433006464 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 478433006465 FeS/SAM binding site; other site 478433006466 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 478433006467 Domain of unknown function (DUF222); Region: DUF222; pfam02720 478433006468 Domain of unknown function (DUF222); Region: DUF222; pfam02720 478433006469 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 478433006470 active site 478433006471 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 478433006472 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 478433006473 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 478433006474 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 478433006475 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 478433006476 catalytic residue [active] 478433006477 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 478433006478 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 478433006479 inhibitor-cofactor binding pocket; inhibition site 478433006480 pyridoxal 5'-phosphate binding site [chemical binding]; other site 478433006481 catalytic residue [active] 478433006482 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 478433006483 NlpC/P60 family; Region: NLPC_P60; pfam00877 478433006484 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 478433006485 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 478433006486 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 478433006487 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 478433006488 active site 478433006489 catalytic site [active] 478433006490 malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401 478433006491 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 478433006492 active site 478433006493 catalytic site [active] 478433006494 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 478433006495 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 478433006496 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 478433006497 catalytic site [active] 478433006498 active site 478433006499 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 478433006500 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 478433006501 putative active site [active] 478433006502 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 478433006503 threonine dehydratase; Validated; Region: PRK08639 478433006504 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 478433006505 tetramer interface [polypeptide binding]; other site 478433006506 pyridoxal 5'-phosphate binding site [chemical binding]; other site 478433006507 catalytic residue [active] 478433006508 C-terminal regulatory domain of Threonine dehydratase; Region: Thr_dehydrat_C; pfam00585 478433006509 Domain of unknown function (DUF385); Region: DUF385; pfam04075 478433006510 MMPL family; Region: MMPL; pfam03176 478433006511 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 478433006512 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478433006513 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 478433006514 Iron-sulfur protein interface; other site 478433006515 proximal quinone binding site [chemical binding]; other site 478433006516 C-subunit interface; other site 478433006517 distal quinone binding site; other site 478433006518 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 478433006519 D-subunit interface [polypeptide binding]; other site 478433006520 Iron-sulfur protein interface; other site 478433006521 proximal quinone binding site [chemical binding]; other site 478433006522 distal quinone binding site [chemical binding]; other site 478433006523 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 478433006524 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 478433006525 fumarate reductase, flavoprotein subunit; Region: fum_red_Fp; TIGR01176 478433006526 L-aspartate oxidase; Provisional; Region: PRK06175 478433006527 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 478433006528 glycerol-3-phosphate acyltransferase; Reviewed; Region: PRK11915 478433006529 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 478433006530 putative acyl-acceptor binding pocket; other site 478433006531 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 478433006532 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 478433006533 acyl-activating enzyme (AAE) consensus motif; other site 478433006534 putative AMP binding site [chemical binding]; other site 478433006535 putative active site [active] 478433006536 putative CoA binding site [chemical binding]; other site 478433006537 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478433006538 PPE family; Region: PPE; pfam00823 478433006539 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478433006540 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478433006541 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 478433006542 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 478433006543 active site 478433006544 PHP Thumb interface [polypeptide binding]; other site 478433006545 metal binding site [ion binding]; metal-binding site 478433006546 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 478433006547 generic binding surface II; other site 478433006548 generic binding surface I; other site 478433006549 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 478433006550 hydrophobic ligand binding site; other site 478433006551 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 478433006552 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 478433006553 NAD(P) binding site [chemical binding]; other site 478433006554 active site 478433006555 short chain dehydrogenase; Provisional; Region: PRK05866 478433006556 classical (c) SDRs; Region: SDR_c; cd05233 478433006557 NAD(P) binding site [chemical binding]; other site 478433006558 active site 478433006559 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 478433006560 apolar tunnel; other site 478433006561 heme binding site [chemical binding]; other site 478433006562 dimerization interface [polypeptide binding]; other site 478433006563 Uncharacterized protein conserved in bacteria, putative lipoprotein [Function unknown]; Region: LprI; COG4461 478433006564 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 478433006565 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 478433006566 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 478433006567 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 478433006568 active site 478433006569 lipoprotein signal peptidase; Provisional; Region: PRK14764 478433006570 lipoprotein signal peptidase; Provisional; Region: PRK14787 478433006571 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 478433006572 active site 478433006573 homodimer interface [polypeptide binding]; other site 478433006574 homotetramer interface [polypeptide binding]; other site 478433006575 DNA polymerase IV; Provisional; Region: PRK03348 478433006576 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 478433006577 active site 478433006578 DNA binding site [nucleotide binding] 478433006579 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 478433006580 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 478433006581 HIGH motif; other site 478433006582 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 478433006583 active site 478433006584 KMSKS motif; other site 478433006585 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 478433006586 tRNA binding surface [nucleotide binding]; other site 478433006587 anticodon binding site; other site 478433006588 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478433006589 Nitronate monooxygenase; Region: NMO; pfam03060 478433006590 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 478433006591 FMN binding site [chemical binding]; other site 478433006592 substrate binding site [chemical binding]; other site 478433006593 putative catalytic residue [active] 478433006594 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 478433006595 CoenzymeA binding site [chemical binding]; other site 478433006596 subunit interaction site [polypeptide binding]; other site 478433006597 PHB binding site; other site 478433006598 Uncharacterized conserved protein [Function unknown]; Region: COG2128 478433006599 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 478433006600 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 478433006601 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 478433006602 NAD(P) binding site [chemical binding]; other site 478433006603 acyl-CoA synthetase; Validated; Region: PRK05850 478433006604 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 478433006605 acyl-activating enzyme (AAE) consensus motif; other site 478433006606 active site 478433006607 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 478433006608 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 478433006609 active site 478433006610 Acyl transferase domain; Region: Acyl_transf_1; pfam00698 478433006611 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 478433006612 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 478433006613 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 478433006614 Enoylreductase; Region: PKS_ER; smart00829 478433006615 NAD(P) binding site [chemical binding]; other site 478433006616 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 478433006617 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 478433006618 putative NADP binding site [chemical binding]; other site 478433006619 active site 478433006620 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 478433006621 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 478433006622 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 478433006623 homodimer interface [polypeptide binding]; other site 478433006624 active site 478433006625 TDP-binding site; other site 478433006626 acceptor substrate-binding pocket; other site 478433006627 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 478433006628 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 478433006629 Probable Catalytic site; other site 478433006630 metal-binding site 478433006631 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 478433006632 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 478433006633 homodimer interface [polypeptide binding]; other site 478433006634 active site 478433006635 TDP-binding site; other site 478433006636 acceptor substrate-binding pocket; other site 478433006637 Methyltransferase domain; Region: Methyltransf_23; pfam13489 478433006638 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478433006639 S-adenosylmethionine binding site [chemical binding]; other site 478433006640 Transport protein; Region: actII; TIGR00833 478433006641 acyl-CoA synthetase; Validated; Region: PRK05850 478433006642 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 478433006643 acyl-activating enzyme (AAE) consensus motif; other site 478433006644 active site 478433006645 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 478433006646 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 478433006647 active site 478433006648 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 478433006649 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 478433006650 active site 478433006651 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 478433006652 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 478433006653 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 478433006654 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 478433006655 active site 478433006656 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478433006657 S-adenosylmethionine binding site [chemical binding]; other site 478433006658 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 478433006659 metal-binding site 478433006660 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 478433006661 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 478433006662 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 478433006663 NADP binding site [chemical binding]; other site 478433006664 active site 478433006665 putative substrate binding site [chemical binding]; other site 478433006666 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 478433006667 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 478433006668 NADP-binding site; other site 478433006669 homotetramer interface [polypeptide binding]; other site 478433006670 substrate binding site [chemical binding]; other site 478433006671 homodimer interface [polypeptide binding]; other site 478433006672 active site 478433006673 Methyltransferase domain; Region: Methyltransf_23; pfam13489 478433006674 Methyltransferase domain; Region: Methyltransf_12; pfam08242 478433006675 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 478433006676 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 478433006677 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 478433006678 WbqC-like protein family; Region: WbqC; pfam08889 478433006679 Methyltransferase domain; Region: Methyltransf_12; pfam08242 478433006680 S-adenosylmethionine binding site [chemical binding]; other site 478433006681 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 478433006682 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 478433006683 putative trimer interface [polypeptide binding]; other site 478433006684 putative CoA binding site [chemical binding]; other site 478433006685 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 478433006686 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 478433006687 inhibitor-cofactor binding pocket; inhibition site 478433006688 pyridoxal 5'-phosphate binding site [chemical binding]; other site 478433006689 catalytic residue [active] 478433006690 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 478433006691 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 478433006692 Glycosyl hydrolase families 32 and 68, which for the clan GH-J; Region: GH_J; cd08979 478433006693 active site 478433006694 Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5285 478433006695 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 478433006696 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 478433006697 Ligand binding site; other site 478433006698 Putative Catalytic site; other site 478433006699 DXD motif; other site 478433006700 Uncharacterized conserved protein [Function unknown]; Region: COG3360 478433006701 Methyltransferase domain; Region: Methyltransf_31; pfam13847 478433006702 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478433006703 S-adenosylmethionine binding site [chemical binding]; other site 478433006704 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 478433006705 Beta-lactamase; Region: Beta-lactamase; pfam00144 478433006706 membrane ATPase/protein kinase; Provisional; Region: PRK09435 478433006707 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 478433006708 Walker A; other site 478433006709 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 478433006710 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 478433006711 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 478433006712 active site 478433006713 substrate binding site [chemical binding]; other site 478433006714 coenzyme B12 binding site [chemical binding]; other site 478433006715 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 478433006716 B12 binding site [chemical binding]; other site 478433006717 cobalt ligand [ion binding]; other site 478433006718 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 478433006719 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 478433006720 heterodimer interface [polypeptide binding]; other site 478433006721 substrate interaction site [chemical binding]; other site 478433006722 Methylmalonyl-CoA mutase, C-terminal domain/subunit (cobalamin-binding) [Lipid metabolism]; Region: Sbm; COG2185 478433006723 Uncharacterized conserved protein [Function unknown]; Region: COG0398 478433006724 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 478433006725 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 478433006726 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 478433006727 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 478433006728 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 478433006729 ferrochelatase; Reviewed; Region: hemH; PRK00035 478433006730 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 478433006731 C-terminal domain interface [polypeptide binding]; other site 478433006732 active site 478433006733 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 478433006734 active site 478433006735 N-terminal domain interface [polypeptide binding]; other site 478433006736 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 478433006737 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 478433006738 NAD binding site [chemical binding]; other site 478433006739 homotetramer interface [polypeptide binding]; other site 478433006740 homodimer interface [polypeptide binding]; other site 478433006741 substrate binding site [chemical binding]; other site 478433006742 active site 478433006743 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 478433006744 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 478433006745 NAD(P) binding site [chemical binding]; other site 478433006746 homotetramer interface [polypeptide binding]; other site 478433006747 homodimer interface [polypeptide binding]; other site 478433006748 active site 478433006749 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 478433006750 hypothetical protein; Provisional; Region: PRK13685 478433006751 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 478433006752 metal ion-dependent adhesion site (MIDAS); other site 478433006753 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 478433006754 Protein of unknown function DUF58; Region: DUF58; pfam01882 478433006755 MoxR-like ATPases [General function prediction only]; Region: COG0714 478433006756 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 478433006757 Walker A motif; other site 478433006758 ATP binding site [chemical binding]; other site 478433006759 Walker B motif; other site 478433006760 arginine finger; other site 478433006761 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 478433006762 NlpC/P60 family; Region: NLPC_P60; pfam00877 478433006763 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 478433006764 NlpC/P60 family; Region: NLPC_P60; pfam00877 478433006765 aconitate hydratase; Validated; Region: PRK09277 478433006766 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 478433006767 substrate binding site [chemical binding]; other site 478433006768 ligand binding site [chemical binding]; other site 478433006769 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 478433006770 substrate binding site [chemical binding]; other site 478433006771 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 478433006772 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478433006773 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 478433006774 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 478433006775 Walker A/P-loop; other site 478433006776 ATP binding site [chemical binding]; other site 478433006777 Q-loop/lid; other site 478433006778 ABC transporter signature motif; other site 478433006779 Walker B; other site 478433006780 D-loop; other site 478433006781 H-loop/switch region; other site 478433006782 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 478433006783 enoyl-CoA hydratase; Provisional; Region: PRK05864 478433006784 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 478433006785 substrate binding site [chemical binding]; other site 478433006786 oxyanion hole (OAH) forming residues; other site 478433006787 trimer interface [polypeptide binding]; other site 478433006788 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 478433006789 catalytic residues [active] 478433006790 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 478433006791 catalytic residues [active] 478433006792 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 478433006793 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 478433006794 PE family; Region: PE; pfam00934 478433006795 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 478433006796 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 478433006797 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 478433006798 active site 478433006799 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 478433006800 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 478433006801 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 478433006802 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 478433006803 trimerization site [polypeptide binding]; other site 478433006804 active site 478433006805 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 478433006806 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 478433006807 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 478433006808 catalytic residue [active] 478433006809 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 478433006810 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 478433006811 Walker A/P-loop; other site 478433006812 ATP binding site [chemical binding]; other site 478433006813 Q-loop/lid; other site 478433006814 ABC transporter signature motif; other site 478433006815 Walker B; other site 478433006816 D-loop; other site 478433006817 H-loop/switch region; other site 478433006818 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 478433006819 FeS assembly protein SufD; Region: sufD; TIGR01981 478433006820 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 478433006821 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 478433006822 protein-splicing catalytic site; other site 478433006823 thioester formation/cholesterol transfer; other site 478433006824 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 478433006825 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 478433006826 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 478433006827 Predicted transcriptional regulator [Transcription]; Region: COG2345 478433006828 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 478433006829 putative DNA binding site [nucleotide binding]; other site 478433006830 putative Zn2+ binding site [ion binding]; other site 478433006831 Transcriptional regulator PadR-like family; Region: PadR; cl17335 478433006832 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 478433006833 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 478433006834 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 478433006835 Walker A/P-loop; other site 478433006836 ATP binding site [chemical binding]; other site 478433006837 Q-loop/lid; other site 478433006838 ABC transporter signature motif; other site 478433006839 Walker B; other site 478433006840 D-loop; other site 478433006841 H-loop/switch region; other site 478433006842 ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025 478433006843 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 478433006844 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 478433006845 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 478433006846 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 478433006847 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 478433006848 NADP binding site [chemical binding]; other site 478433006849 dimer interface [polypeptide binding]; other site 478433006850 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 478433006851 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 478433006852 PE family; Region: PE; pfam00934 478433006853 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 478433006854 UbiA prenyltransferase family; Region: UbiA; pfam01040 478433006855 PE family; Region: PE; pfam00934 478433006856 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 478433006857 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 478433006858 TPP-binding site [chemical binding]; other site 478433006859 dimer interface [polypeptide binding]; other site 478433006860 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 478433006861 PYR/PP interface [polypeptide binding]; other site 478433006862 dimer interface [polypeptide binding]; other site 478433006863 TPP binding site [chemical binding]; other site 478433006864 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 478433006865 putative active site [active] 478433006866 transaldolase; Provisional; Region: PRK03903 478433006867 catalytic residue [active] 478433006868 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 478433006869 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 478433006870 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 478433006871 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 478433006872 Glucose-6-P dehydrogenase subunit [Carbohydrate transport and metabolism]; Region: COG3429 478433006873 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 478433006874 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 478433006875 putative active site [active] 478433006876 Proteins of 100 residues with WXG; Region: WXG100; cl02005 478433006877 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 478433006878 hydrophobic ligand binding site; other site 478433006879 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 478433006880 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 478433006881 molybdopterin cofactor binding site [chemical binding]; other site 478433006882 substrate binding site [chemical binding]; other site 478433006883 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 478433006884 molybdopterin cofactor binding site; other site 478433006885 PE family; Region: PE; pfam00934 478433006886 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 478433006887 SnoaL-like domain; Region: SnoaL_2; pfam12680 478433006888 triosephosphate isomerase; Provisional; Region: PRK14567 478433006889 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 478433006890 substrate binding site [chemical binding]; other site 478433006891 dimer interface [polypeptide binding]; other site 478433006892 catalytic triad [active] 478433006893 Phosphoglycerate kinase; Region: PGK; pfam00162 478433006894 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 478433006895 substrate binding site [chemical binding]; other site 478433006896 hinge regions; other site 478433006897 ADP binding site [chemical binding]; other site 478433006898 catalytic site [active] 478433006899 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 478433006900 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 478433006901 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 478433006902 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 478433006903 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 478433006904 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 478433006905 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 478433006906 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 478433006907 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 478433006908 PE family; Region: PE; pfam00934 478433006909 PE-PPE domain; Region: PE-PPE; pfam08237 478433006910 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 478433006911 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 478433006912 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 478433006913 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 478433006914 putative acyl-acceptor binding pocket; other site 478433006915 acyl-CoA synthetase; Provisional; Region: PRK13382 478433006916 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 478433006917 acyl-activating enzyme (AAE) consensus motif; other site 478433006918 putative AMP binding site [chemical binding]; other site 478433006919 putative active site [active] 478433006920 putative CoA binding site [chemical binding]; other site 478433006921 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 478433006922 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 478433006923 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 478433006924 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 478433006925 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 478433006926 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 478433006927 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 478433006928 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 478433006929 phosphate binding site [ion binding]; other site 478433006930 putative substrate binding pocket [chemical binding]; other site 478433006931 dimer interface [polypeptide binding]; other site 478433006932 P-loop ATPase protein family; Region: ATP_bind_2; pfam03668 478433006933 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 478433006934 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 478433006935 GIY-YIG motif/motif A; other site 478433006936 active site 478433006937 catalytic site [active] 478433006938 putative DNA binding site [nucleotide binding]; other site 478433006939 metal binding site [ion binding]; metal-binding site 478433006940 UvrB/uvrC motif; Region: UVR; pfam02151 478433006941 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 478433006942 Helix-hairpin-helix motif; Region: HHH; pfam00633 478433006943 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 478433006944 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 478433006945 putative sugar binding sites [chemical binding]; other site 478433006946 Q-X-W motif; other site 478433006947 PknH-like extracellular domain; Region: PknH_C; pfam14032 478433006948 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 478433006949 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 478433006950 homopentamer interface [polypeptide binding]; other site 478433006951 active site 478433006952 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 478433006953 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 478433006954 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 478433006955 dimerization interface [polypeptide binding]; other site 478433006956 active site 478433006957 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 478433006958 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 478433006959 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 478433006960 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 478433006961 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 478433006962 Lumazine binding domain; Region: Lum_binding; pfam00677 478433006963 Lumazine binding domain; Region: Lum_binding; pfam00677 478433006964 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 478433006965 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 478433006966 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 478433006967 putative substrate translocation pore; other site 478433006968 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 478433006969 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 478433006970 catalytic motif [active] 478433006971 Zn binding site [ion binding]; other site 478433006972 RibD C-terminal domain; Region: RibD_C; pfam01872 478433006973 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 478433006974 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 478433006975 substrate binding site [chemical binding]; other site 478433006976 hexamer interface [polypeptide binding]; other site 478433006977 metal binding site [ion binding]; metal-binding site 478433006978 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 478433006979 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 478433006980 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 478433006981 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 478433006982 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 478433006983 putative active site [active] 478433006984 substrate binding site [chemical binding]; other site 478433006985 putative cosubstrate binding site; other site 478433006986 catalytic site [active] 478433006987 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 478433006988 substrate binding site [chemical binding]; other site 478433006989 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478433006990 S-adenosylmethionine binding site [chemical binding]; other site 478433006991 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 478433006992 MarR family; Region: MarR; pfam01047 478433006993 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478433006994 S-adenosylmethionine binding site [chemical binding]; other site 478433006995 primosome assembly protein PriA; Provisional; Region: PRK14873 478433006996 Predicted membrane protein [Function unknown]; Region: COG3714 478433006997 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 478433006998 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 478433006999 substrate binding pocket [chemical binding]; other site 478433007000 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 478433007001 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 478433007002 substrate binding pocket [chemical binding]; other site 478433007003 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 478433007004 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 478433007005 oligomeric interface; other site 478433007006 putative active site [active] 478433007007 homodimer interface [polypeptide binding]; other site 478433007008 PE family; Region: PE; pfam00934 478433007009 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 478433007010 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 478433007011 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 478433007012 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 478433007013 Cytochrome P450; Region: p450; cl12078 478433007014 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 478433007015 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 478433007016 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 478433007017 S-adenosylmethionine synthetase; Validated; Region: PRK05250 478433007018 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 478433007019 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 478433007020 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 478433007021 Flavoprotein; Region: Flavoprotein; pfam02441 478433007022 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 478433007023 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 478433007024 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 478433007025 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 478433007026 catalytic site [active] 478433007027 G-X2-G-X-G-K; other site 478433007028 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478433007029 PPE family; Region: PPE; pfam00823 478433007030 PE family; Region: PE; pfam00934 478433007031 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 478433007032 active site 478433007033 dimer interface [polypeptide binding]; other site 478433007034 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 478433007035 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 478433007036 ATP-grasp domain; Region: ATP-grasp_4; cl17255 478433007037 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 478433007038 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 478433007039 ATP-grasp domain; Region: ATP-grasp_4; cl17255 478433007040 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 478433007041 IMP binding site; other site 478433007042 dimer interface [polypeptide binding]; other site 478433007043 interdomain contacts; other site 478433007044 partial ornithine binding site; other site 478433007045 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 478433007046 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 478433007047 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 478433007048 catalytic site [active] 478433007049 subunit interface [polypeptide binding]; other site 478433007050 dihydroorotase; Validated; Region: pyrC; PRK09357 478433007051 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 478433007052 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 478433007053 active site 478433007054 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 478433007055 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 478433007056 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 478433007057 bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; Provisional; Region: PRK05205 478433007058 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 478433007059 Domain of unknown function (DUF222); Region: DUF222; pfam02720 478433007060 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 478433007061 active site 478433007062 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478433007063 S-adenosylmethionine binding site [chemical binding]; other site 478433007064 Uncharacterized conserved protein [Function unknown]; Region: COG3482 478433007065 uncharacterized domain; Region: TIGR00702 478433007066 YcaO-like family; Region: YcaO; pfam02624 478433007067 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 478433007068 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 478433007069 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 478433007070 malonyl-CoA binding site [chemical binding]; other site 478433007071 dimer interface [polypeptide binding]; other site 478433007072 active site 478433007073 product binding site; other site 478433007074 Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; pfam00173 478433007075 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 478433007076 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 478433007077 putative di-iron ligands [ion binding]; other site 478433007078 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 478433007079 Beta-lactamase; Region: Beta-lactamase; pfam00144 478433007080 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 478433007081 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 478433007082 synthetase active site [active] 478433007083 NTP binding site [chemical binding]; other site 478433007084 metal binding site [ion binding]; metal-binding site 478433007085 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 478433007086 anti sigma factor interaction site; other site 478433007087 regulatory phosphorylation site [posttranslational modification]; other site 478433007088 PAS fold; Region: PAS_4; pfam08448 478433007089 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 478433007090 putative active site [active] 478433007091 heme pocket [chemical binding]; other site 478433007092 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 478433007093 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 478433007094 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 478433007095 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 478433007096 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 478433007097 anti sigma factor interaction site; other site 478433007098 regulatory phosphorylation site [posttranslational modification]; other site 478433007099 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478433007100 PPE family; Region: PPE; pfam00823 478433007101 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 478433007102 probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841 478433007103 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 478433007104 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 478433007105 cyclase homology domain; Region: CHD; cd07302 478433007106 Predicted ATPase [General function prediction only]; Region: COG3903 478433007107 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 478433007108 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 478433007109 DNA binding residues [nucleotide binding] 478433007110 dimerization interface [polypeptide binding]; other site 478433007111 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 478433007112 cyclase homology domain; Region: CHD; cd07302 478433007113 nucleotidyl binding site; other site 478433007114 dimer interface [polypeptide binding]; other site 478433007115 metal binding site [ion binding]; metal-binding site 478433007116 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 478433007117 hypothetical protein; Provisional; Region: PRK07877 478433007118 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 478433007119 ATP binding site [chemical binding]; other site 478433007120 substrate interface [chemical binding]; other site 478433007121 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 478433007122 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 478433007123 GAF domain; Region: GAF; pfam01590 478433007124 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 478433007125 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 478433007126 metal binding site [ion binding]; metal-binding site 478433007127 active site 478433007128 I-site; other site 478433007129 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 478433007130 tetracycline repressor protein TetR; Provisional; Region: PRK13756 478433007131 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478433007132 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 478433007133 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 478433007134 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 478433007135 NAD(P) binding site [chemical binding]; other site 478433007136 active site 478433007137 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 478433007138 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 478433007139 Walker A/P-loop; other site 478433007140 ATP binding site [chemical binding]; other site 478433007141 Q-loop/lid; other site 478433007142 ABC transporter signature motif; other site 478433007143 Walker B; other site 478433007144 D-loop; other site 478433007145 H-loop/switch region; other site 478433007146 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 478433007147 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 478433007148 FAD binding pocket [chemical binding]; other site 478433007149 FAD binding motif [chemical binding]; other site 478433007150 phosphate binding motif [ion binding]; other site 478433007151 NAD binding pocket [chemical binding]; other site 478433007152 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 478433007153 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 478433007154 Walker A/P-loop; other site 478433007155 ATP binding site [chemical binding]; other site 478433007156 Q-loop/lid; other site 478433007157 ABC transporter signature motif; other site 478433007158 Walker B; other site 478433007159 D-loop; other site 478433007160 H-loop/switch region; other site 478433007161 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 478433007162 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 478433007163 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 478433007164 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 478433007165 active site 478433007166 long-chain-fatty-acid--[acyl-carrier-protein] ligase; Validated; Region: PRK05851 478433007167 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 478433007168 acyl-activating enzyme (AAE) consensus motif; other site 478433007169 active site 478433007170 acyl carrier protein; Validated; Region: PRK05883 478433007171 Glucitol operon activator [Transcription]; Region: GutM; COG4578 478433007172 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 478433007173 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 478433007174 active site 478433007175 dimerization interface [polypeptide binding]; other site 478433007176 ribonuclease PH; Reviewed; Region: rph; PRK00173 478433007177 Ribonuclease PH; Region: RNase_PH_bact; cd11362 478433007178 hexamer interface [polypeptide binding]; other site 478433007179 active site 478433007180 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 478433007181 glutamate racemase; Provisional; Region: PRK00865 478433007182 Rhomboid family; Region: Rhomboid; pfam01694 478433007183 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 478433007184 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 478433007185 dimer interface [polypeptide binding]; other site 478433007186 pyridoxal 5'-phosphate binding site [chemical binding]; other site 478433007187 catalytic residue [active] 478433007188 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 478433007189 MoaE interaction surface [polypeptide binding]; other site 478433007190 MoeB interaction surface [polypeptide binding]; other site 478433007191 thiocarboxylated glycine; other site 478433007192 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 478433007193 MPN+ (JAMM) motif; other site 478433007194 Zinc-binding site [ion binding]; other site 478433007195 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 478433007196 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 478433007197 putative active site pocket [active] 478433007198 cleavage site 478433007199 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 478433007200 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 478433007201 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 478433007202 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 478433007203 active site 478433007204 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 478433007205 DEAD/DEAH box helicase; Region: DEAD; pfam00270 478433007206 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 478433007207 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 478433007208 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 478433007209 putative homodimer interface [polypeptide binding]; other site 478433007210 putative active site pocket [active] 478433007211 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 478433007212 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 478433007213 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 478433007214 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 478433007215 active site 478433007216 homodimer interface [polypeptide binding]; other site 478433007217 catalytic site [active] 478433007218 acceptor binding site [chemical binding]; other site 478433007219 glycogen branching enzyme; Provisional; Region: PRK05402 478433007220 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 478433007221 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 478433007222 active site 478433007223 catalytic site [active] 478433007224 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 478433007225 PE family; Region: PE; pfam00934 478433007226 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 478433007227 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 478433007228 putative acyltransferase; Provisional; Region: PRK05790 478433007229 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 478433007230 dimer interface [polypeptide binding]; other site 478433007231 active site 478433007232 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 478433007233 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 478433007234 dimer interface [polypeptide binding]; other site 478433007235 substrate binding site [chemical binding]; other site 478433007236 metal binding site [ion binding]; metal-binding site 478433007237 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 478433007238 hypothetical protein; Provisional; Region: PRK03298 478433007239 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 478433007240 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 478433007241 dimerization interface [polypeptide binding]; other site 478433007242 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 478433007243 cyclase homology domain; Region: CHD; cd07302 478433007244 nucleotidyl binding site; other site 478433007245 metal binding site [ion binding]; metal-binding site 478433007246 dimer interface [polypeptide binding]; other site 478433007247 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 478433007248 dimerization interface [polypeptide binding]; other site 478433007249 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 478433007250 cyclase homology domain; Region: CHD; cd07302 478433007251 nucleotidyl binding site; other site 478433007252 metal binding site [ion binding]; metal-binding site 478433007253 dimer interface [polypeptide binding]; other site 478433007254 HAMP domain; Region: HAMP; pfam00672 478433007255 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 478433007256 cyclase homology domain; Region: CHD; cd07302 478433007257 nucleotidyl binding site; other site 478433007258 metal binding site [ion binding]; metal-binding site 478433007259 dimer interface [polypeptide binding]; other site 478433007260 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 478433007261 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 478433007262 AlkA N-terminal domain; Region: AlkA_N; pfam06029 478433007263 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 478433007264 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 478433007265 minor groove reading motif; other site 478433007266 helix-hairpin-helix signature motif; other site 478433007267 substrate binding pocket [chemical binding]; other site 478433007268 active site 478433007269 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 478433007270 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 478433007271 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 478433007272 DNA binding site [nucleotide binding] 478433007273 active site 478433007274 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 478433007275 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 478433007276 hinge; other site 478433007277 active site 478433007278 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 478433007279 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 478433007280 Transposase; Region: DDE_Tnp_ISL3; pfam01610 478433007281 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 478433007282 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 478433007283 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 478433007284 gamma subunit interface [polypeptide binding]; other site 478433007285 epsilon subunit interface [polypeptide binding]; other site 478433007286 LBP interface [polypeptide binding]; other site 478433007287 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 478433007288 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 478433007289 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 478433007290 alpha subunit interaction interface [polypeptide binding]; other site 478433007291 Walker A motif; other site 478433007292 ATP binding site [chemical binding]; other site 478433007293 Walker B motif; other site 478433007294 inhibitor binding site; inhibition site 478433007295 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 478433007296 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 478433007297 core domain interface [polypeptide binding]; other site 478433007298 delta subunit interface [polypeptide binding]; other site 478433007299 epsilon subunit interface [polypeptide binding]; other site 478433007300 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 478433007301 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 478433007302 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 478433007303 Walker A motif; other site 478433007304 ATP binding site [chemical binding]; other site 478433007305 Walker B motif; other site 478433007306 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 478433007307 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13428 478433007308 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 478433007309 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 478433007310 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 478433007311 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 478433007312 F0F1 ATP synthase subunit C; Validated; Region: PRK05880 478433007313 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 478433007314 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 478433007315 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 478433007316 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 478433007317 Mg++ binding site [ion binding]; other site 478433007318 putative catalytic motif [active] 478433007319 substrate binding site [chemical binding]; other site 478433007320 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 478433007321 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 478433007322 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478433007323 S-adenosylmethionine binding site [chemical binding]; other site 478433007324 peptide chain release factor 1; Region: prfA; TIGR00019 478433007325 This domain is found in peptide chain release factors; Region: PCRF; smart00937 478433007326 RF-1 domain; Region: RF-1; pfam00472 478433007327 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 478433007328 transcription termination factor Rho; Provisional; Region: PRK12678 478433007329 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 478433007330 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 478433007331 RNA binding site [nucleotide binding]; other site 478433007332 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 478433007333 multimer interface [polypeptide binding]; other site 478433007334 Walker A motif; other site 478433007335 ATP binding site [chemical binding]; other site 478433007336 Walker B motif; other site 478433007337 Homoserine kinase [Amino acid transport and metabolism]; Region: ThrB; COG0083 478433007338 threonine synthase; Reviewed; Region: PRK06721 478433007339 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 478433007340 homodimer interface [polypeptide binding]; other site 478433007341 pyridoxal 5'-phosphate binding site [chemical binding]; other site 478433007342 catalytic residue [active] 478433007343 homoserine dehydrogenase; Provisional; Region: PRK06349 478433007344 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 478433007345 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 478433007346 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 478433007347 diaminopimelate decarboxylase; Region: lysA; TIGR01048 478433007348 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 478433007349 active site 478433007350 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 478433007351 substrate binding site [chemical binding]; other site 478433007352 catalytic residues [active] 478433007353 dimer interface [polypeptide binding]; other site 478433007354 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 478433007355 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 478433007356 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 478433007357 active site 478433007358 HIGH motif; other site 478433007359 KMSK motif region; other site 478433007360 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 478433007361 tRNA binding surface [nucleotide binding]; other site 478433007362 anticodon binding site; other site 478433007363 Protein of unknown function (DUF732); Region: DUF732; pfam05305 478433007364 Predicted membrane protein [Function unknown]; Region: COG4325 478433007365 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 478433007366 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 478433007367 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 478433007368 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 478433007369 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 478433007370 Putative esterase; Region: Esterase; pfam00756 478433007371 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 478433007372 Rrf2 family protein; Region: rrf2_super; TIGR00738 478433007373 Transcriptional regulator; Region: Rrf2; pfam02082 478433007374 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 478433007375 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 478433007376 CysD dimerization site [polypeptide binding]; other site 478433007377 G1 box; other site 478433007378 putative GEF interaction site [polypeptide binding]; other site 478433007379 GTP/Mg2+ binding site [chemical binding]; other site 478433007380 Switch I region; other site 478433007381 G2 box; other site 478433007382 G3 box; other site 478433007383 Switch II region; other site 478433007384 G4 box; other site 478433007385 G5 box; other site 478433007386 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 478433007387 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 478433007388 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 478433007389 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 478433007390 Walker A/P-loop; other site 478433007391 ligand-binding site [chemical binding]; other site 478433007392 ATP binding site [chemical binding]; other site 478433007393 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 478433007394 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 478433007395 Active Sites [active] 478433007396 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 478433007397 active site clefts [active] 478433007398 zinc binding site [ion binding]; other site 478433007399 dimer interface [polypeptide binding]; other site 478433007400 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 478433007401 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 478433007402 dimer interface [polypeptide binding]; other site 478433007403 conserved gate region; other site 478433007404 putative PBP binding loops; other site 478433007405 ABC-ATPase subunit interface; other site 478433007406 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 478433007407 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 478433007408 dimer interface [polypeptide binding]; other site 478433007409 conserved gate region; other site 478433007410 putative PBP binding loops; other site 478433007411 ABC-ATPase subunit interface; other site 478433007412 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 478433007413 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 478433007414 Walker A/P-loop; other site 478433007415 ATP binding site [chemical binding]; other site 478433007416 Q-loop/lid; other site 478433007417 ABC transporter signature motif; other site 478433007418 Walker B; other site 478433007419 D-loop; other site 478433007420 H-loop/switch region; other site 478433007421 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 478433007422 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 478433007423 Walker A/P-loop; other site 478433007424 ATP binding site [chemical binding]; other site 478433007425 Q-loop/lid; other site 478433007426 ABC transporter signature motif; other site 478433007427 Walker B; other site 478433007428 D-loop; other site 478433007429 H-loop/switch region; other site 478433007430 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 478433007431 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 478433007432 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 478433007433 choline dehydrogenase; Validated; Region: PRK02106 478433007434 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 478433007435 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 478433007436 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 478433007437 Walker A/P-loop; other site 478433007438 ATP binding site [chemical binding]; other site 478433007439 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 478433007440 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 478433007441 active site 478433007442 metal binding site [ion binding]; metal-binding site 478433007443 DNA binding site [nucleotide binding] 478433007444 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 478433007445 catalytic core [active] 478433007446 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 478433007447 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 478433007448 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 478433007449 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 478433007450 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 478433007451 Walker A/P-loop; other site 478433007452 ATP binding site [chemical binding]; other site 478433007453 Q-loop/lid; other site 478433007454 ABC transporter signature motif; other site 478433007455 Walker B; other site 478433007456 D-loop; other site 478433007457 H-loop/switch region; other site 478433007458 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 478433007459 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 478433007460 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 478433007461 Walker A/P-loop; other site 478433007462 ATP binding site [chemical binding]; other site 478433007463 Q-loop/lid; other site 478433007464 ABC transporter signature motif; other site 478433007465 Walker B; other site 478433007466 D-loop; other site 478433007467 H-loop/switch region; other site 478433007468 Protein of unknown function (DUF732); Region: DUF732; pfam05305 478433007469 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 478433007470 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 478433007471 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 478433007472 putative active site [active] 478433007473 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 478433007474 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 478433007475 DNA binding site [nucleotide binding] 478433007476 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 478433007477 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 478433007478 phosphopeptide binding site; other site 478433007479 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 478433007480 Catalytic domain of Protein Kinases; Region: PKc; cd00180 478433007481 active site 478433007482 ATP binding site [chemical binding]; other site 478433007483 substrate binding site [chemical binding]; other site 478433007484 activation loop (A-loop); other site 478433007485 PknH-like extracellular domain; Region: PknH_C; pfam14032 478433007486 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 478433007487 cyclase homology domain; Region: CHD; cd07302 478433007488 nucleotidyl binding site; other site 478433007489 metal binding site [ion binding]; metal-binding site 478433007490 dimer interface [polypeptide binding]; other site 478433007491 amidase; Provisional; Region: PRK12470 478433007492 Amidase; Region: Amidase; pfam01425 478433007493 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 478433007494 HIT family signature motif; other site 478433007495 catalytic residue [active] 478433007496 Domain of unknown function (DUF385); Region: DUF385; pfam04075 478433007497 hypothetical protein; Validated; Region: PRK05868 478433007498 hypothetical protein; Provisional; Region: PRK07236 478433007499 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 478433007500 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 478433007501 Fe-S cluster binding site [ion binding]; other site 478433007502 DNA binding site [nucleotide binding] 478433007503 active site 478433007504 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 478433007505 H+ Antiporter protein; Region: 2A0121; TIGR00900 478433007506 putative substrate translocation pore; other site 478433007507 FAD binding domain; Region: FAD_binding_4; pfam01565 478433007508 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 478433007509 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 478433007510 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 478433007511 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478433007512 Acyltransferase family; Region: Acyl_transf_3; pfam01757 478433007513 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 478433007514 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 478433007515 ATP binding site [chemical binding]; other site 478433007516 Mg++ binding site [ion binding]; other site 478433007517 motif III; other site 478433007518 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 478433007519 nucleotide binding region [chemical binding]; other site 478433007520 ATP-binding site [chemical binding]; other site 478433007521 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 478433007522 putative RNA binding site [nucleotide binding]; other site 478433007523 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 478433007524 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 478433007525 RNase_H superfamily; Region: RNase_H_2; pfam13482 478433007526 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 478433007527 Part of AAA domain; Region: AAA_19; pfam13245 478433007528 AAA domain; Region: AAA_12; pfam13087 478433007529 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 478433007530 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 478433007531 putative substrate translocation pore; other site 478433007532 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 478433007533 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 478433007534 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 478433007535 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 478433007536 TPP-binding site [chemical binding]; other site 478433007537 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 478433007538 dimer interface [polypeptide binding]; other site 478433007539 PYR/PP interface [polypeptide binding]; other site 478433007540 TPP binding site [chemical binding]; other site 478433007541 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 478433007542 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 478433007543 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 478433007544 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 478433007545 NAD(P) binding site [chemical binding]; other site 478433007546 active site 478433007547 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 478433007548 PE family; Region: PE; pfam00934 478433007549 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 478433007550 malate dehydrogenase; Provisional; Region: PRK05442 478433007551 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 478433007552 NAD(P) binding site [chemical binding]; other site 478433007553 dimer interface [polypeptide binding]; other site 478433007554 malate binding site [chemical binding]; other site 478433007555 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 478433007556 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 478433007557 oligomer interface [polypeptide binding]; other site 478433007558 metal binding site [ion binding]; metal-binding site 478433007559 metal binding site [ion binding]; metal-binding site 478433007560 putative Cl binding site [ion binding]; other site 478433007561 basic sphincter; other site 478433007562 hydrophobic gate; other site 478433007563 periplasmic entrance; other site 478433007564 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 478433007565 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 478433007566 Walker A/P-loop; other site 478433007567 ATP binding site [chemical binding]; other site 478433007568 Q-loop/lid; other site 478433007569 ABC transporter signature motif; other site 478433007570 Walker B; other site 478433007571 D-loop; other site 478433007572 H-loop/switch region; other site 478433007573 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 478433007574 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 478433007575 dimer interface [polypeptide binding]; other site 478433007576 conserved gate region; other site 478433007577 ABC-ATPase subunit interface; other site 478433007578 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 478433007579 dimer interface [polypeptide binding]; other site 478433007580 conserved gate region; other site 478433007581 putative PBP binding loops; other site 478433007582 ABC-ATPase subunit interface; other site 478433007583 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 478433007584 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 478433007585 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 478433007586 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 478433007587 MgtE intracellular N domain; Region: MgtE_N; smart00924 478433007588 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 478433007589 Predicted membrane protein [Function unknown]; Region: COG4420 478433007590 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 478433007591 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 478433007592 N-acetyl-D-glucosamine binding site [chemical binding]; other site 478433007593 catalytic residue [active] 478433007594 Domain of unknown function DUF59; Region: DUF59; cl00941 478433007595 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 478433007596 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 478433007597 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 478433007598 Uncharacterized conserved protein [Function unknown]; Region: COG3402 478433007599 Predicted membrane protein [Function unknown]; Region: COG3428 478433007600 Bacterial PH domain; Region: DUF304; pfam03703 478433007601 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 478433007602 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 478433007603 active site 478433007604 motif I; other site 478433007605 motif II; other site 478433007606 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 478433007607 sec-independent translocase; Provisional; Region: PRK03100 478433007608 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 478433007609 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 478433007610 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 478433007611 protein binding site [polypeptide binding]; other site 478433007612 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647 478433007613 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 478433007614 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 478433007615 DNA binding residues [nucleotide binding] 478433007616 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 478433007617 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478433007618 S-adenosylmethionine binding site [chemical binding]; other site 478433007619 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478433007620 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 478433007621 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 478433007622 Walker A/P-loop; other site 478433007623 ATP binding site [chemical binding]; other site 478433007624 Q-loop/lid; other site 478433007625 ABC transporter signature motif; other site 478433007626 Walker B; other site 478433007627 D-loop; other site 478433007628 H-loop/switch region; other site 478433007629 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 478433007630 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 478433007631 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 478433007632 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 478433007633 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 478433007634 PE family; Region: PE; pfam00934 478433007635 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 478433007636 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 478433007637 ligand binding site; other site 478433007638 oligomer interface; other site 478433007639 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 478433007640 dimer interface [polypeptide binding]; other site 478433007641 N-terminal domain interface [polypeptide binding]; other site 478433007642 sulfate 1 binding site; other site 478433007643 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 478433007644 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 478433007645 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 478433007646 DNA-3-methyladenine glycosylase I; Region: tag; TIGR00624 478433007647 DivIVA domain; Region: DivI1A_domain; TIGR03544 478433007648 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 478433007649 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 478433007650 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 478433007651 dihydropteroate synthase; Region: DHPS; TIGR01496 478433007652 substrate binding pocket [chemical binding]; other site 478433007653 dimer interface [polypeptide binding]; other site 478433007654 inhibitor binding site; inhibition site 478433007655 long-chain-acyl-CoA synthetase; Validated; Region: PRK08279 478433007656 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 478433007657 acyl-activating enzyme (AAE) consensus motif; other site 478433007658 putative AMP binding site [chemical binding]; other site 478433007659 putative active site [active] 478433007660 putative CoA binding site [chemical binding]; other site 478433007661 TIGR00730 family protein; Region: TIGR00730 478433007662 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 478433007663 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 478433007664 metal binding site [ion binding]; metal-binding site 478433007665 putative dimer interface [polypeptide binding]; other site 478433007666 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 478433007667 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 478433007668 putative trimer interface [polypeptide binding]; other site 478433007669 putative CoA binding site [chemical binding]; other site 478433007670 metabolite-proton symporter; Region: 2A0106; TIGR00883 478433007671 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 478433007672 putative substrate translocation pore; other site 478433007673 Transposase, Mutator family; Region: Transposase_mut; pfam00872 478433007674 MULE transposase domain; Region: MULE; pfam10551 478433007675 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 478433007676 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 478433007677 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478433007678 PPE family; Region: PPE; pfam00823 478433007679 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 478433007680 PE family; Region: PE; pfam00934 478433007681 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 478433007682 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 478433007683 acyl-CoA synthetase; Validated; Region: PRK07787 478433007684 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 478433007685 acyl-activating enzyme (AAE) consensus motif; other site 478433007686 AMP binding site [chemical binding]; other site 478433007687 active site 478433007688 CoA binding site [chemical binding]; other site 478433007689 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 478433007690 PGAP1-like protein; Region: PGAP1; pfam07819 478433007691 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 478433007692 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 478433007693 haloalkane dehalogenase; Provisional; Region: PRK03204 478433007694 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 478433007695 catalytic site [active] 478433007696 RNA polymerase sigma factor SigI; Provisional; Region: sigI; PRK09635 478433007697 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 478433007698 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 478433007699 DNA binding residues [nucleotide binding] 478433007700 Proline dehydrogenase; Region: Pro_dh; pfam01619 478433007701 Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123 478433007702 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 478433007703 Glutamate binding site [chemical binding]; other site 478433007704 NAD binding site [chemical binding]; other site 478433007705 catalytic residues [active] 478433007706 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 478433007707 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 478433007708 acyl-CoA synthetase; Validated; Region: PRK05850 478433007709 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 478433007710 acyl-activating enzyme (AAE) consensus motif; other site 478433007711 active site 478433007712 PE-PPE domain; Region: PE-PPE; pfam08237 478433007713 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 478433007714 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 478433007715 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 478433007716 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 478433007717 active site 478433007718 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 478433007719 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 478433007720 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 478433007721 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 478433007722 Enoylreductase; Region: PKS_ER; smart00829 478433007723 NAD(P) binding site [chemical binding]; other site 478433007724 KR domain; Region: KR; pfam08659 478433007725 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 478433007726 putative NADP binding site [chemical binding]; other site 478433007727 active site 478433007728 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 478433007729 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 478433007730 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 478433007731 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 478433007732 ATP binding site [chemical binding]; other site 478433007733 putative Mg++ binding site [ion binding]; other site 478433007734 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 478433007735 ATP-binding site [chemical binding]; other site 478433007736 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 478433007737 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 478433007738 pyridoxal 5'-phosphate binding site [chemical binding]; other site 478433007739 homodimer interface [polypeptide binding]; other site 478433007740 catalytic residue [active] 478433007741 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 478433007742 4Fe-4S binding domain; Region: Fer4; pfam00037 478433007743 Predicted transcriptional regulators [Transcription]; Region: COG1695 478433007744 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 478433007745 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 478433007746 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 478433007747 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 478433007748 active site 478433007749 FMN binding site [chemical binding]; other site 478433007750 2,4-decadienoyl-CoA binding site; other site 478433007751 catalytic residue [active] 478433007752 4Fe-4S cluster binding site [ion binding]; other site 478433007753 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 478433007754 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 478433007755 FO synthase; Reviewed; Region: fbiC; PRK09234 478433007756 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 478433007757 FeS/SAM binding site; other site 478433007758 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 478433007759 FeS/SAM binding site; other site 478433007760 PE family; Region: PE; pfam00934 478433007761 N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D- glucopyranoside deacetylase; Region: mycothiol_MshB; TIGR03445 478433007762 PE family; Region: PE; pfam00934 478433007763 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478433007764 PPE family; Region: PPE; pfam00823 478433007765 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 478433007766 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 478433007767 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478433007768 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 478433007769 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 478433007770 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 478433007771 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 478433007772 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 478433007773 G1 box; other site 478433007774 putative GEF interaction site [polypeptide binding]; other site 478433007775 GTP/Mg2+ binding site [chemical binding]; other site 478433007776 Switch I region; other site 478433007777 G2 box; other site 478433007778 G3 box; other site 478433007779 Switch II region; other site 478433007780 G4 box; other site 478433007781 G5 box; other site 478433007782 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 478433007783 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 478433007784 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 478433007785 nitrate reductase molybdenum cofactor assembly chaperone; Region: narJ; TIGR00684 478433007786 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 478433007787 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 478433007788 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 478433007789 [4Fe-4S] binding site [ion binding]; other site 478433007790 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 478433007791 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 478433007792 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 478433007793 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 478433007794 molybdopterin cofactor binding site; other site 478433007795 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 478433007796 active site 478433007797 8-oxo-dGMP binding site [chemical binding]; other site 478433007798 nudix motif; other site 478433007799 metal binding site [ion binding]; metal-binding site 478433007800 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 478433007801 aromatic arch; other site 478433007802 DCoH dimer interaction site [polypeptide binding]; other site 478433007803 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 478433007804 DCoH tetramer interaction site [polypeptide binding]; other site 478433007805 substrate binding site [chemical binding]; other site 478433007806 mannosyltransferase; Provisional; Region: pimE; PRK13375 478433007807 uncharacterized HhH-GPD family protein; Region: TIGR03252 478433007808 minor groove reading motif; other site 478433007809 helix-hairpin-helix signature motif; other site 478433007810 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 478433007811 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797 478433007812 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 478433007813 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 478433007814 Predicted transcriptional regulators [Transcription]; Region: COG1725 478433007815 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 478433007816 DNA-binding site [nucleotide binding]; DNA binding site 478433007817 NAD-dependent deacetylase; Provisional; Region: PRK00481 478433007818 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 478433007819 NAD+ binding site [chemical binding]; other site 478433007820 substrate binding site [chemical binding]; other site 478433007821 Zn binding site [ion binding]; other site 478433007822 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 478433007823 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 478433007824 Domain of unknown function (DUF222); Region: DUF222; pfam02720 478433007825 Domain of unknown function (DUF222); Region: DUF222; pfam02720 478433007826 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 478433007827 active site 478433007828 DDE superfamily endonuclease; Region: DDE_5; cl17874 478433007829 MMPL family; Region: MMPL; pfam03176 478433007830 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 478433007831 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 478433007832 NAD binding site [chemical binding]; other site 478433007833 homodimer interface [polypeptide binding]; other site 478433007834 homotetramer interface [polypeptide binding]; other site 478433007835 active site 478433007836 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 478433007837 CoA-transferase family III; Region: CoA_transf_3; pfam02515 478433007838 enoyl-CoA hydratase; Provisional; Region: PRK06688 478433007839 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 478433007840 substrate binding site [chemical binding]; other site 478433007841 oxyanion hole (OAH) forming residues; other site 478433007842 trimer interface [polypeptide binding]; other site 478433007843 enoyl-CoA hydratase; Provisional; Region: PRK06688 478433007844 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 478433007845 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 478433007846 trimer interface [polypeptide binding]; other site 478433007847 CAAX protease self-immunity; Region: Abi; pfam02517 478433007848 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 478433007849 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 478433007850 enoyl-CoA hydratase; Provisional; Region: PRK06494 478433007851 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 478433007852 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 478433007853 substrate binding site [chemical binding]; other site 478433007854 oxyanion hole (OAH) forming residues; other site 478433007855 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 478433007856 active site 478433007857 PPE family; Region: PPE; pfam00823 478433007858 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478433007859 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 478433007860 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 478433007861 THF binding site; other site 478433007862 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 478433007863 substrate binding site [chemical binding]; other site 478433007864 THF binding site; other site 478433007865 zinc-binding site [ion binding]; other site 478433007866 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 478433007867 citrate synthase; Provisional; Region: PRK14033 478433007868 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 478433007869 oxalacetate binding site [chemical binding]; other site 478433007870 citrylCoA binding site [chemical binding]; other site 478433007871 coenzyme A binding site [chemical binding]; other site 478433007872 catalytic triad [active] 478433007873 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 478433007874 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 478433007875 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 478433007876 non-specific DNA binding site [nucleotide binding]; other site 478433007877 salt bridge; other site 478433007878 sequence-specific DNA binding site [nucleotide binding]; other site 478433007879 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 478433007880 Domain of unknown function (DUF955); Region: DUF955; pfam06114 478433007881 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 478433007882 Domain of unknown function (DUF222); Region: DUF222; pfam02720 478433007883 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 478433007884 active site 478433007885 pyruvate phosphate dikinase; Provisional; Region: PRK05878 478433007886 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 478433007887 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700 478433007888 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 478433007889 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 478433007890 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 478433007891 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 478433007892 6-phosphogluconate dehydrogenase (decarboxylating); Region: gnd_rel; TIGR00872 478433007893 glucose-6-phosphate 1-dehydrogenase; Region: zwf; TIGR00871 478433007894 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 478433007895 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 478433007896 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 478433007897 cyclase homology domain; Region: CHD; cd07302 478433007898 nucleotidyl binding site; other site 478433007899 metal binding site [ion binding]; metal-binding site 478433007900 dimer interface [polypeptide binding]; other site 478433007901 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 478433007902 Uncharacterized conserved protein [Function unknown]; Region: COG1359 478433007903 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: VapC; COG1487 478433007904 putative active site [active] 478433007905 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 478433007906 GTP-binding protein YchF; Reviewed; Region: PRK09601 478433007907 YchF GTPase; Region: YchF; cd01900 478433007908 G1 box; other site 478433007909 GTP/Mg2+ binding site [chemical binding]; other site 478433007910 Switch I region; other site 478433007911 G2 box; other site 478433007912 Switch II region; other site 478433007913 G3 box; other site 478433007914 G4 box; other site 478433007915 G5 box; other site 478433007916 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 478433007917 Yip1 domain; Region: Yip1; pfam04893 478433007918 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 478433007919 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 478433007920 Exonuclease VII, large subunit [DNA replication, recombination, and repair]; Region: XseA; COG1570 478433007921 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 478433007922 generic binding surface II; other site 478433007923 generic binding surface I; other site 478433007924 exodeoxyribonuclease VII, small subunit; Region: xseB; TIGR01280 478433007925 3beta-hydroxysteroid dehydrogenases (3b-HSD)-like, extended (e) SDRs; Region: 3b-HSD-like_SDR_e; cd05241 478433007926 3-beta hydroxysteroid dehydrogenase/isomerase family; Region: 3Beta_HSD; pfam01073 478433007927 putative NAD(P) binding site [chemical binding]; other site 478433007928 active site 478433007929 putative substrate binding site [chemical binding]; other site 478433007930 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 478433007931 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 478433007932 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 478433007933 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 478433007934 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 478433007935 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 478433007936 Domain of unknown function DUF20; Region: UPF0118; pfam01594 478433007937 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 478433007938 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 478433007939 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 478433007940 putative active site [active] 478433007941 fumarate hydratase; Reviewed; Region: fumC; PRK00485 478433007942 Class II fumarases; Region: Fumarase_classII; cd01362 478433007943 active site 478433007944 tetramer interface [polypeptide binding]; other site 478433007945 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 478433007946 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 478433007947 NodB motif; other site 478433007948 active site 478433007949 catalytic site [active] 478433007950 metal binding site [ion binding]; metal-binding site 478433007951 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 478433007952 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 478433007953 putative active site [active] 478433007954 PhoH-like protein; Region: PhoH; pfam02562 478433007955 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 478433007956 dinuclear metal binding motif [ion binding]; other site 478433007957 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 478433007958 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 478433007959 dimer interface [polypeptide binding]; other site 478433007960 active site 478433007961 glycine-pyridoxal phosphate binding site [chemical binding]; other site 478433007962 folate binding site [chemical binding]; other site 478433007963 pantothenate kinase; Provisional; Region: PRK05439 478433007964 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 478433007965 ATP-binding site [chemical binding]; other site 478433007966 CoA-binding site [chemical binding]; other site 478433007967 Mg2+-binding site [ion binding]; other site 478433007968 PE family; Region: PE; pfam00934 478433007969 Glycosyl hydrolase family 12; Region: Glyco_hydro_12; pfam01670 478433007970 PE family; Region: PE; pfam00934 478433007971 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 478433007972 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 478433007973 putative IPP diphosphate binding site; other site 478433007974 PE family; Region: PE; pfam00934 478433007975 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 478433007976 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 478433007977 catalytic residue [active] 478433007978 putative FPP diphosphate binding site; other site 478433007979 putative FPP binding hydrophobic cleft; other site 478433007980 dimer interface [polypeptide binding]; other site 478433007981 putative IPP diphosphate binding site; other site 478433007982 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 478433007983 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 478433007984 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 478433007985 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 478433007986 catalytic residues [active] 478433007987 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 478433007988 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 478433007989 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 478433007990 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 478433007991 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 478433007992 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 478433007993 cystathionine gamma-synthase; Provisional; Region: PRK07811 478433007994 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 478433007995 homodimer interface [polypeptide binding]; other site 478433007996 substrate-cofactor binding pocket; other site 478433007997 pyridoxal 5'-phosphate binding site [chemical binding]; other site 478433007998 catalytic residue [active] 478433007999 RDD family; Region: RDD; pfam06271 478433008000 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 478433008001 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 478433008002 dimer interface [polypeptide binding]; other site 478433008003 pyridoxal 5'-phosphate binding site [chemical binding]; other site 478433008004 catalytic residue [active] 478433008005 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 478433008006 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 478433008007 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 478433008008 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 478433008009 active site 478433008010 catalytic triad [active] 478433008011 oxyanion hole [active] 478433008012 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 478433008013 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 478433008014 dimer interface [polypeptide binding]; other site 478433008015 active site 478433008016 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 478433008017 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 478433008018 Predicted membrane protein [Function unknown]; Region: COG4760 478433008019 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 478433008020 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 478433008021 substrate binding site [chemical binding]; other site 478433008022 oxyanion hole (OAH) forming residues; other site 478433008023 trimer interface [polypeptide binding]; other site 478433008024 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 478433008025 enoyl-CoA hydratase; Provisional; Region: PRK05862 478433008026 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 478433008027 substrate binding site [chemical binding]; other site 478433008028 oxyanion hole (OAH) forming residues; other site 478433008029 trimer interface [polypeptide binding]; other site 478433008030 Predicted membrane protein [Function unknown]; Region: COG4425 478433008031 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 478433008032 PE family; Region: PE; pfam00934 478433008033 PE family; Region: PE; pfam00934 478433008034 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 478433008035 active site residue [active] 478433008036 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 478433008037 hypothetical protein; Provisional; Region: PRK10279 478433008038 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 478433008039 active site 478433008040 nucleophile elbow; other site 478433008041 Patatin-like phospholipase; Region: Patatin; pfam01734 478433008042 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 478433008043 nucleophile elbow; other site 478433008044 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 478433008045 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 478433008046 putative active site [active] 478433008047 putative dimer interface [polypeptide binding]; other site 478433008048 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 478433008049 hydrophobic ligand binding site; other site 478433008050 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 478433008051 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 478433008052 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 478433008053 dimer interface [polypeptide binding]; other site 478433008054 acyl-activating enzyme (AAE) consensus motif; other site 478433008055 putative active site [active] 478433008056 AMP binding site [chemical binding]; other site 478433008057 putative CoA binding site [chemical binding]; other site 478433008058 Uncharacterized conserved protein [Function unknown]; Region: COG3391 478433008059 Domain of unknown function (DUF427); Region: DUF427; cl00998 478433008060 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 478433008061 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 478433008062 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 478433008063 Helix-turn-helix domain; Region: HTH_17; pfam12728 478433008064 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 478433008065 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 478433008066 NAD(P) binding site [chemical binding]; other site 478433008067 active site 478433008068 Transcriptional regulators [Transcription]; Region: MarR; COG1846 478433008069 MarR family; Region: MarR_2; pfam12802 478433008070 Transposase, Mutator family; Region: Transposase_mut; pfam00872 478433008071 MULE transposase domain; Region: MULE; pfam10551 478433008072 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 478433008073 Predicted transcriptional regulator [Transcription]; Region: COG5340 478433008074 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 478433008075 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 478433008076 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 478433008077 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 478433008078 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 478433008079 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 478433008080 PE family; Region: PE; pfam00934 478433008081 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 478433008082 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478433008083 PPE family; Region: PPE; pfam00823 478433008084 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 478433008085 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 478433008086 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 478433008087 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 478433008088 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 478433008089 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 478433008090 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 478433008091 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 478433008092 active site 478433008093 phosphorylation site [posttranslational modification] 478433008094 intermolecular recognition site; other site 478433008095 dimerization interface [polypeptide binding]; other site 478433008096 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 478433008097 DNA binding site [nucleotide binding] 478433008098 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 478433008099 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 478433008100 dimer interface [polypeptide binding]; other site 478433008101 phosphorylation site [posttranslational modification] 478433008102 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 478433008103 ATP binding site [chemical binding]; other site 478433008104 Mg2+ binding site [ion binding]; other site 478433008105 G-X-G motif; other site 478433008106 potassium-transporting ATPase subunit C; Provisional; Region: PRK14001 478433008107 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 478433008108 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 478433008109 Soluble P-type ATPase [General function prediction only]; Region: COG4087 478433008110 K+-transporting ATPase, KdpA; Region: kdpA; TIGR00680 478433008111 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 478433008112 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 478433008113 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 478433008114 Ligand Binding Site [chemical binding]; other site 478433008115 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 478433008116 dimer interface [polypeptide binding]; other site 478433008117 phosphorylation site [posttranslational modification] 478433008118 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 478433008119 ATP binding site [chemical binding]; other site 478433008120 Mg2+ binding site [ion binding]; other site 478433008121 G-X-G motif; other site 478433008122 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 478433008123 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 478433008124 active site 478433008125 phosphorylation site [posttranslational modification] 478433008126 intermolecular recognition site; other site 478433008127 dimerization interface [polypeptide binding]; other site 478433008128 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 478433008129 DNA binding site [nucleotide binding] 478433008130 exopolyphosphatase; Region: exo_poly_only; TIGR03706 478433008131 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 478433008132 Uncharacterized conserved protein [Function unknown]; Region: COG1507 478433008133 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 478433008134 Septum formation initiator; Region: DivIC; pfam04977 478433008135 enolase; Provisional; Region: eno; PRK00077 478433008136 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 478433008137 dimer interface [polypeptide binding]; other site 478433008138 metal binding site [ion binding]; metal-binding site 478433008139 substrate binding pocket [chemical binding]; other site 478433008140 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 478433008141 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 478433008142 N-acetyl-D-glucosamine binding site [chemical binding]; other site 478433008143 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334 478433008144 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 478433008145 homodimer interface [polypeptide binding]; other site 478433008146 metal binding site [ion binding]; metal-binding site 478433008147 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 478433008148 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 478433008149 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 478433008150 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 478433008151 ATP binding site [chemical binding]; other site 478433008152 putative Mg++ binding site [ion binding]; other site 478433008153 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 478433008154 nucleotide binding region [chemical binding]; other site 478433008155 ATP-binding site [chemical binding]; other site 478433008156 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 478433008157 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 478433008158 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478433008159 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 478433008160 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 478433008161 Substrate binding site; other site 478433008162 Mg++ binding site; other site 478433008163 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 478433008164 active site 478433008165 substrate binding site [chemical binding]; other site 478433008166 CoA binding site [chemical binding]; other site 478433008167 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 478433008168 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 478433008169 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 478433008170 active site 478433008171 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 478433008172 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 478433008173 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 478433008174 5S rRNA interface [nucleotide binding]; other site 478433008175 CTC domain interface [polypeptide binding]; other site 478433008176 L16 interface [polypeptide binding]; other site 478433008177 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 478433008178 putative active site [active] 478433008179 catalytic residue [active] 478433008180 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 478433008181 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 478433008182 acyl-activating enzyme (AAE) consensus motif; other site 478433008183 AMP binding site [chemical binding]; other site 478433008184 active site 478433008185 CoA binding site [chemical binding]; other site 478433008186 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 478433008187 Increased loss of mitochondrial DNA protein 1; Region: Ilm1; pfam10311 478433008188 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 478433008189 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 478433008190 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478433008191 S-adenosylmethionine binding site [chemical binding]; other site 478433008192 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 478433008193 Domain of unknown function (DUF348); Region: DUF348; pfam03990 478433008194 Domain of unknown function (DUF348); Region: DUF348; pfam03990 478433008195 G5 domain; Region: G5; pfam07501 478433008196 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 478433008197 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 478433008198 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 478433008199 active site 478433008200 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 478433008201 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 478433008202 active site 478433008203 HIGH motif; other site 478433008204 KMSKS motif; other site 478433008205 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 478433008206 tRNA binding surface [nucleotide binding]; other site 478433008207 anticodon binding site; other site 478433008208 aminodeoxychorismate synthase component I; Provisional; Region: PRK05877 478433008209 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 478433008210 Predicted methyltransferases [General function prediction only]; Region: COG0313 478433008211 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 478433008212 putative SAM binding site [chemical binding]; other site 478433008213 putative homodimer interface [polypeptide binding]; other site 478433008214 Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928 478433008215 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 478433008216 arginine deiminase; Provisional; Region: PRK01388 478433008217 Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145 478433008218 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 478433008219 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 478433008220 ligand binding site [chemical binding]; other site 478433008221 flexible hinge region; other site 478433008222 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 478433008223 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 478433008224 Coenzyme A binding pocket [chemical binding]; other site 478433008225 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 478433008226 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 478433008227 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 478433008228 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 478433008229 dimer interface [polypeptide binding]; other site 478433008230 putative functional site; other site 478433008231 putative MPT binding site; other site 478433008232 UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210 478433008233 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 478433008234 active site 478433008235 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 478433008236 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 478433008237 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2331 478433008238 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 478433008239 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 478433008240 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 478433008241 substrate binding pocket [chemical binding]; other site 478433008242 chain length determination region; other site 478433008243 substrate-Mg2+ binding site; other site 478433008244 catalytic residues [active] 478433008245 aspartate-rich region 1; other site 478433008246 active site lid residues [active] 478433008247 aspartate-rich region 2; other site 478433008248 Predicted secreted hydrolase [General function prediction only]; Region: COG5621 478433008249 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 478433008250 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 478433008251 FtsX-like permease family; Region: FtsX; pfam02687 478433008252 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 478433008253 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 478433008254 FtsX-like permease family; Region: FtsX; pfam02687 478433008255 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 478433008256 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 478433008257 Walker A/P-loop; other site 478433008258 ATP binding site [chemical binding]; other site 478433008259 Q-loop/lid; other site 478433008260 ABC transporter signature motif; other site 478433008261 Walker B; other site 478433008262 D-loop; other site 478433008263 H-loop/switch region; other site 478433008264 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 478433008265 Large-conductance mechanosensitive channel, MscL; Region: MscL; pfam01741 478433008266 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 478433008267 MPT binding site; other site 478433008268 trimer interface [polypeptide binding]; other site 478433008269 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 478433008270 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 478433008271 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 478433008272 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 478433008273 dimerization interface [polypeptide binding]; other site 478433008274 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 478433008275 dimer interface [polypeptide binding]; other site 478433008276 phosphorylation site [posttranslational modification] 478433008277 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 478433008278 ATP binding site [chemical binding]; other site 478433008279 Mg2+ binding site [ion binding]; other site 478433008280 G-X-G motif; other site 478433008281 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 478433008282 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 478433008283 active site 478433008284 phosphorylation site [posttranslational modification] 478433008285 intermolecular recognition site; other site 478433008286 dimerization interface [polypeptide binding]; other site 478433008287 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 478433008288 DNA binding site [nucleotide binding] 478433008289 PE family; Region: PE; pfam00934 478433008290 Uncharacterized conserved protein [Function unknown]; Region: COG3391 478433008291 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 478433008292 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 478433008293 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 478433008294 PE family; Region: PE; pfam00934 478433008295 Uncharacterized conserved protein [Function unknown]; Region: COG3391 478433008296 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 478433008297 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 478433008298 PE family; Region: PE; pfam00934 478433008299 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 478433008300 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 478433008301 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 478433008302 active site 478433008303 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 478433008304 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 478433008305 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 478433008306 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 478433008307 ATP-grasp domain; Region: ATP-grasp_4; cl17255 478433008308 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 478433008309 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 478433008310 carboxyltransferase (CT) interaction site; other site 478433008311 biotinylation site [posttranslational modification]; other site 478433008312 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 478433008313 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 478433008314 active site 478433008315 enoyl-CoA hydratase; Provisional; Region: PRK07827 478433008316 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 478433008317 substrate binding site [chemical binding]; other site 478433008318 oxyanion hole (OAH) forming residues; other site 478433008319 trimer interface [polypeptide binding]; other site 478433008320 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 478433008321 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 478433008322 Soluble P-type ATPase [General function prediction only]; Region: COG4087 478433008323 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 478433008324 Thermus thermophilus CsoR, a Cu(I)-sensing transcriptional regulator, and related domains; this domain family was previously known as part of DUF156; Region: TthCsoR-like_DUF156; cd10151 478433008325 putative homodimer interface [polypeptide binding]; other site 478433008326 putative homotetramer interface [polypeptide binding]; other site 478433008327 allosteric switch controlling residues; other site 478433008328 putative metal binding site [ion binding]; other site 478433008329 putative homodimer-homodimer interface [polypeptide binding]; other site 478433008330 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 478433008331 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 478433008332 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 478433008333 homotetrameric interface [polypeptide binding]; other site 478433008334 putative active site [active] 478433008335 metal binding site [ion binding]; metal-binding site 478433008336 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 478433008337 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 478433008338 metal ion-dependent adhesion site (MIDAS); other site 478433008339 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 478433008340 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 478433008341 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 478433008342 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 478433008343 purine monophosphate binding site [chemical binding]; other site 478433008344 dimer interface [polypeptide binding]; other site 478433008345 putative catalytic residues [active] 478433008346 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 478433008347 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 478433008348 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 478433008349 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 478433008350 active site 478433008351 substrate binding site [chemical binding]; other site 478433008352 cosubstrate binding site; other site 478433008353 catalytic site [active] 478433008354 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 478433008355 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 478433008356 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 478433008357 CoA binding domain; Region: CoA_binding; smart00881 478433008358 CoA-ligase; Region: Ligase_CoA; pfam00549 478433008359 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 478433008360 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 478433008361 CoA-ligase; Region: Ligase_CoA; pfam00549 478433008362 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 478433008363 Peptidase family M23; Region: Peptidase_M23; pfam01551 478433008364 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 478433008365 Part of AAA domain; Region: AAA_19; pfam13245 478433008366 Family description; Region: UvrD_C_2; pfam13538 478433008367 hypothetical protein; Provisional; Region: PRK07857 478433008368 Predicted esterase [General function prediction only]; Region: COG0627 478433008369 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 478433008370 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 478433008371 active site 478433008372 dimer interface [polypeptide binding]; other site 478433008373 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 478433008374 dimer interface [polypeptide binding]; other site 478433008375 active site 478433008376 short chain dehydrogenase; Provisional; Region: PRK08251 478433008377 classical (c) SDR, subgroup 6; Region: SDR_c6; cd05350 478433008378 putative NAD(P) binding site [chemical binding]; other site 478433008379 active site 478433008380 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 478433008381 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 478433008382 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 478433008383 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 478433008384 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 478433008385 anti sigma factor interaction site; other site 478433008386 regulatory phosphorylation site [posttranslational modification]; other site 478433008387 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 478433008388 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 478433008389 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 478433008390 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 478433008391 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 478433008392 ATP-dependent DNA ligase; Reviewed; Region: PRK09632 478433008393 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 478433008394 nucleotide binding site [chemical binding]; other site 478433008395 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 478433008396 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 478433008397 active site 478433008398 DNA binding site [nucleotide binding] 478433008399 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 478433008400 DNA binding site [nucleotide binding] 478433008401 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 478433008402 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 478433008403 putative DNA binding site [nucleotide binding]; other site 478433008404 putative homodimer interface [polypeptide binding]; other site 478433008405 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 478433008406 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 478433008407 dimer interface [polypeptide binding]; other site 478433008408 conserved gate region; other site 478433008409 putative PBP binding loops; other site 478433008410 ABC-ATPase subunit interface; other site 478433008411 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 478433008412 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 478433008413 dimer interface [polypeptide binding]; other site 478433008414 conserved gate region; other site 478433008415 putative PBP binding loops; other site 478433008416 ABC-ATPase subunit interface; other site 478433008417 phosphate ABC transporter, phosphate-binding protein; Region: 3a0107s03; TIGR00975 478433008418 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14271 478433008419 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 478433008420 Walker A/P-loop; other site 478433008421 ATP binding site [chemical binding]; other site 478433008422 Q-loop/lid; other site 478433008423 ABC transporter signature motif; other site 478433008424 Walker B; other site 478433008425 D-loop; other site 478433008426 H-loop/switch region; other site 478433008427 PBP superfamily domain; Region: PBP_like_2; cl17296 478433008428 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 478433008429 Catalytic domain of Protein Kinases; Region: PKc; cd00180 478433008430 active site 478433008431 ATP binding site [chemical binding]; other site 478433008432 substrate binding site [chemical binding]; other site 478433008433 activation loop (A-loop); other site 478433008434 Uncharacterized conserved protein [Function unknown]; Region: COG3391 478433008435 NHL repeat; Region: NHL; pfam01436 478433008436 NHL repeat; Region: NHL; pfam01436 478433008437 NHL repeat; Region: NHL; pfam01436 478433008438 NHL repeat; Region: NHL; pfam01436 478433008439 NHL repeat; Region: NHL; pfam01436 478433008440 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 478433008441 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 478433008442 dimer interface [polypeptide binding]; other site 478433008443 conserved gate region; other site 478433008444 putative PBP binding loops; other site 478433008445 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 478433008446 ABC-ATPase subunit interface; other site 478433008447 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 478433008448 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 478433008449 dimer interface [polypeptide binding]; other site 478433008450 conserved gate region; other site 478433008451 putative PBP binding loops; other site 478433008452 ABC-ATPase subunit interface; other site 478433008453 phosphate ABC transporter, phosphate-binding protein; Region: 3a0107s03; TIGR00975 478433008454 short chain dehydrogenase; Provisional; Region: PRK07814 478433008455 classical (c) SDRs; Region: SDR_c; cd05233 478433008456 NAD(P) binding site [chemical binding]; other site 478433008457 active site 478433008458 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 478433008459 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 478433008460 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 478433008461 manganese transport protein MntH; Reviewed; Region: PRK00701 478433008462 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 478433008463 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 478433008464 putative active site pocket [active] 478433008465 dimerization interface [polypeptide binding]; other site 478433008466 putative catalytic residue [active] 478433008467 Phage-related replication protein [General function prediction only]; Region: COG4195 478433008468 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 478433008469 Probable transposase; Region: OrfB_IS605; pfam01385 478433008470 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 478433008471 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 478433008472 catalytic residues [active] 478433008473 catalytic nucleophile [active] 478433008474 Transposase, Mutator family; Region: Transposase_mut; pfam00872 478433008475 MULE transposase domain; Region: MULE; pfam10551 478433008476 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 478433008477 Coenzyme A binding pocket [chemical binding]; other site 478433008478 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 478433008479 BCCT family transporter; Region: BCCT; pfam02028 478433008480 PE family; Region: PE; pfam00934 478433008481 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478433008482 PPE family; Region: PPE; pfam00823 478433008483 acetyl-CoA acetyltransferase; Provisional; Region: PRK06289 478433008484 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 478433008485 active site 478433008486 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 478433008487 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 478433008488 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 478433008489 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 478433008490 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 478433008491 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 478433008492 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 478433008493 hydrophobic ligand binding site; other site 478433008494 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 478433008495 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 478433008496 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 478433008497 Soluble P-type ATPase [General function prediction only]; Region: COG4087 478433008498 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 478433008499 Beta-lactamase; Region: Beta-lactamase; pfam00144 478433008500 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 478433008501 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 478433008502 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 478433008503 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 478433008504 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 478433008505 substrate binding site [chemical binding]; other site 478433008506 oxyanion hole (OAH) forming residues; other site 478433008507 trimer interface [polypeptide binding]; other site 478433008508 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 478433008509 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; COG0825 478433008510 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 478433008511 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 478433008512 active site 478433008513 phosphorylation site [posttranslational modification] 478433008514 intermolecular recognition site; other site 478433008515 dimerization interface [polypeptide binding]; other site 478433008516 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 478433008517 DNA binding site [nucleotide binding] 478433008518 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 478433008519 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 478433008520 dimerization interface [polypeptide binding]; other site 478433008521 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 478433008522 dimer interface [polypeptide binding]; other site 478433008523 phosphorylation site [posttranslational modification] 478433008524 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 478433008525 Mg2+ binding site [ion binding]; other site 478433008526 G-X-G motif; other site 478433008527 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 478433008528 BON domain; Region: BON; pfam04972 478433008529 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 478433008530 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 478433008531 ligand binding site [chemical binding]; other site 478433008532 Protein of unknown function (DUF2630); Region: DUF2630; pfam10944 478433008533 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 478433008534 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 478433008535 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 478433008536 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 478433008537 dimer interface [polypeptide binding]; other site 478433008538 active site 478433008539 citrylCoA binding site [chemical binding]; other site 478433008540 NADH binding [chemical binding]; other site 478433008541 cationic pore residues; other site 478433008542 oxalacetate/citrate binding site [chemical binding]; other site 478433008543 coenzyme A binding site [chemical binding]; other site 478433008544 catalytic triad [active] 478433008545 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 478433008546 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 478433008547 AAA ATPase domain; Region: AAA_16; pfam13191 478433008548 Predicted ATPase [General function prediction only]; Region: COG3903 478433008549 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 478433008550 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 478433008551 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 478433008552 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 478433008553 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 478433008554 cyclase homology domain; Region: CHD; cd07302 478433008555 nucleotidyl binding site; other site 478433008556 metal binding site [ion binding]; metal-binding site 478433008557 dimer interface [polypeptide binding]; other site 478433008558 Predicted ATPase [General function prediction only]; Region: COG3903 478433008559 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 478433008560 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 478433008561 DNA binding residues [nucleotide binding] 478433008562 dimerization interface [polypeptide binding]; other site 478433008563 Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109 478433008564 dimer interface [polypeptide binding]; other site 478433008565 Citrate synthase; Region: Citrate_synt; pfam00285 478433008566 active site 478433008567 citrylCoA binding site [chemical binding]; other site 478433008568 oxalacetate/citrate binding site [chemical binding]; other site 478433008569 coenzyme A binding site [chemical binding]; other site 478433008570 catalytic triad [active] 478433008571 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 478433008572 putative catalytic site [active] 478433008573 putative phosphate binding site [ion binding]; other site 478433008574 putative metal binding site [ion binding]; other site 478433008575 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 478433008576 putative dimer interface [polypeptide binding]; other site 478433008577 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 478433008578 Ferredoxin [Energy production and conversion]; Region: COG1146 478433008579 4Fe-4S binding domain; Region: Fer4; pfam00037 478433008580 ferredoxin-NADP+ reductase; Region: PLN02852 478433008581 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 478433008582 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 478433008583 phosphoserine aminotransferase, putative; Region: serC_3; TIGR01366 478433008584 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 478433008585 catalytic residue [active] 478433008586 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 478433008587 Protein of unknown function (DUF2537); Region: DUF2537; pfam10801 478433008588 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 478433008589 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 478433008590 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 478433008591 MarR family; Region: MarR; pfam01047 478433008592 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 478433008593 Protein of unknown function (DUF2530); Region: DUF2530; pfam10745 478433008594 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478433008595 PPE family; Region: PPE; pfam00823 478433008596 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478433008597 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478433008598 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 478433008599 H+ Antiporter protein; Region: 2A0121; TIGR00900 478433008600 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 478433008601 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398 478433008602 FIST N domain; Region: FIST; pfam08495 478433008603 FIST C domain; Region: FIST_C; pfam10442 478433008604 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 478433008605 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 478433008606 active site 478433008607 PE family; Region: PE; pfam00934 478433008608 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 478433008609 DNA-binding site [nucleotide binding]; DNA binding site 478433008610 RNA-binding motif; other site 478433008611 hypothetical protein; Provisional; Region: PRK11770 478433008612 Domain of unknown function (DUF307); Region: DUF307; pfam03733 478433008613 Domain of unknown function (DUF307); Region: DUF307; pfam03733 478433008614 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 478433008615 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 478433008616 FeS/SAM binding site; other site 478433008617 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 478433008618 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 478433008619 MoaE interaction surface [polypeptide binding]; other site 478433008620 MoeB interaction surface [polypeptide binding]; other site 478433008621 thiocarboxylated glycine; other site 478433008622 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 478433008623 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 478433008624 MoaE homodimer interface [polypeptide binding]; other site 478433008625 MoaD interaction [polypeptide binding]; other site 478433008626 active site residues [active] 478433008627 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 478433008628 MPT binding site; other site 478433008629 trimer interface [polypeptide binding]; other site 478433008630 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 478433008631 trimer interface [polypeptide binding]; other site 478433008632 dimer interface [polypeptide binding]; other site 478433008633 putative active site [active] 478433008634 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 478433008635 WYL domain; Region: WYL; pfam13280 478433008636 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 478433008637 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 478433008638 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 478433008639 ATP binding site [chemical binding]; other site 478433008640 putative Mg++ binding site [ion binding]; other site 478433008641 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 478433008642 nucleotide binding region [chemical binding]; other site 478433008643 ATP-binding site [chemical binding]; other site 478433008644 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 478433008645 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 478433008646 substrate binding site [chemical binding]; other site 478433008647 oxyanion hole (OAH) forming residues; other site 478433008648 trimer interface [polypeptide binding]; other site 478433008649 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 478433008650 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 478433008651 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 478433008652 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 478433008653 dimer interface [polypeptide binding]; other site 478433008654 active site 478433008655 aminotransferase; Validated; Region: PRK07777 478433008656 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 478433008657 pyridoxal 5'-phosphate binding site [chemical binding]; other site 478433008658 homodimer interface [polypeptide binding]; other site 478433008659 catalytic residue [active] 478433008660 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 478433008661 putative hydrophobic ligand binding site [chemical binding]; other site 478433008662 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 478433008663 putative hydrophobic ligand binding site [chemical binding]; other site 478433008664 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 478433008665 CoA-transferase family III; Region: CoA_transf_3; pfam02515 478433008666 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 478433008667 putative hydrophobic ligand binding site [chemical binding]; other site 478433008668 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 478433008669 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 478433008670 dimer interface [polypeptide binding]; other site 478433008671 PYR/PP interface [polypeptide binding]; other site 478433008672 TPP binding site [chemical binding]; other site 478433008673 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 478433008674 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 478433008675 TPP-binding site [chemical binding]; other site 478433008676 dimer interface [polypeptide binding]; other site 478433008677 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 478433008678 short chain dehydrogenase; Provisional; Region: PRK05876 478433008679 classical (c) SDRs; Region: SDR_c; cd05233 478433008680 NAD(P) binding site [chemical binding]; other site 478433008681 active site 478433008682 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 478433008683 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 478433008684 multidrug resistance protein MdtH; Provisional; Region: PRK11646 478433008685 putative substrate translocation pore; other site 478433008686 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 478433008687 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 478433008688 dimer interface [polypeptide binding]; other site 478433008689 pyridoxal 5'-phosphate binding site [chemical binding]; other site 478433008690 catalytic residue [active] 478433008691 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 478433008692 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 478433008693 Multicopper oxidase; Region: Cu-oxidase; pfam00394 478433008694 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 478433008695 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 478433008696 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 478433008697 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 478433008698 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 478433008699 active site 478433008700 phosphorylation site [posttranslational modification] 478433008701 intermolecular recognition site; other site 478433008702 dimerization interface [polypeptide binding]; other site 478433008703 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 478433008704 DNA binding residues [nucleotide binding] 478433008705 dimerization interface [polypeptide binding]; other site 478433008706 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 478433008707 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 478433008708 tetramer interface [polypeptide binding]; other site 478433008709 TPP-binding site [chemical binding]; other site 478433008710 heterodimer interface [polypeptide binding]; other site 478433008711 phosphorylation loop region [posttranslational modification] 478433008712 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 478433008713 putative substrate translocation pore; other site 478433008714 Major Facilitator Superfamily; Region: MFS_1; pfam07690 478433008715 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 478433008716 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478433008717 S-adenosylmethionine binding site [chemical binding]; other site 478433008718 D-ala-D-ala dipeptidase; Region: Peptidase_M15; pfam01427 478433008719 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4861 478433008720 Uncharacterized protein conserved in bacteria (DUF2186); Region: DUF2186; pfam09952 478433008721 Predicted nucleotidyltransferase [General function prediction only]; Region: COG4849 478433008722 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 478433008723 Transposase; Region: HTH_Tnp_1; cl17663 478433008724 putative transposase OrfB; Reviewed; Region: PHA02517 478433008725 HTH-like domain; Region: HTH_21; pfam13276 478433008726 Integrase core domain; Region: rve; pfam00665 478433008727 Integrase core domain; Region: rve_3; pfam13683 478433008728 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 478433008729 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 478433008730 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 478433008731 nucleoside/Zn binding site; other site 478433008732 dimer interface [polypeptide binding]; other site 478433008733 catalytic motif [active] 478433008734 Transposase, Mutator family; Region: Transposase_mut; pfam00872 478433008735 MULE transposase domain; Region: MULE; pfam10551 478433008736 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 478433008737 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 478433008738 ATP binding site [chemical binding]; other site 478433008739 substrate interface [chemical binding]; other site 478433008740 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 478433008741 active site residue [active] 478433008742 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 478433008743 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 478433008744 active site residue [active] 478433008745 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 478433008746 active site residue [active] 478433008747 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 478433008748 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 478433008749 MoaE homodimer interface [polypeptide binding]; other site 478433008750 MoaD interaction [polypeptide binding]; other site 478433008751 active site residues [active] 478433008752 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478433008753 S-adenosylmethionine binding site [chemical binding]; other site 478433008754 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 478433008755 Cytochrome P450; Region: p450; cl12078 478433008756 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 478433008757 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 478433008758 DNA binding site [nucleotide binding] 478433008759 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478433008760 PPE family; Region: PPE; pfam00823 478433008761 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 478433008762 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 478433008763 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 478433008764 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 478433008765 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 478433008766 dimer interface [polypeptide binding]; other site 478433008767 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 478433008768 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 478433008769 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 478433008770 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 478433008771 Histidine kinase; Region: HisKA_3; pfam07730 478433008772 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 478433008773 ATP binding site [chemical binding]; other site 478433008774 Mg2+ binding site [ion binding]; other site 478433008775 G-X-G motif; other site 478433008776 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 478433008777 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 478433008778 active site 478433008779 phosphorylation site [posttranslational modification] 478433008780 intermolecular recognition site; other site 478433008781 dimerization interface [polypeptide binding]; other site 478433008782 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 478433008783 DNA binding residues [nucleotide binding] 478433008784 dimerization interface [polypeptide binding]; other site 478433008785 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 478433008786 Ligand Binding Site [chemical binding]; other site 478433008787 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478433008788 PPE family; Region: PPE; pfam00823 478433008789 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478433008790 PPE family; Region: PPE; pfam00823 478433008791 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 478433008792 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 478433008793 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 478433008794 active site 478433008795 AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337 478433008796 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 478433008797 FeS/SAM binding site; other site 478433008798 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 478433008799 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 478433008800 active site 478433008801 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 478433008802 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 478433008803 active site 478433008804 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 478433008805 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 478433008806 NAD(P) binding site [chemical binding]; other site 478433008807 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 478433008808 active site 478433008809 phosphorylation site [posttranslational modification] 478433008810 intermolecular recognition site; other site 478433008811 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478433008812 PPE family; Region: PPE; pfam00823 478433008813 NADH dehydrogenase subunit A; Validated; Region: PRK07928 478433008814 NADH dehydrogenase subunit B; Validated; Region: PRK06411 478433008815 NADH dehydrogenase subunit C; Provisional; Region: PRK07785 478433008816 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 478433008817 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 478433008818 NADH dehydrogenase subunit D; Validated; Region: PRK06075 478433008819 NADH dehydrogenase subunit E; Validated; Region: PRK07539 478433008820 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 478433008821 putative dimer interface [polypeptide binding]; other site 478433008822 [2Fe-2S] cluster binding site [ion binding]; other site 478433008823 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 478433008824 SLBB domain; Region: SLBB; pfam10531 478433008825 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 478433008826 NADH dehydrogenase subunit G; Validated; Region: PRK07860 478433008827 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 478433008828 catalytic loop [active] 478433008829 iron binding site [ion binding]; other site 478433008830 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 478433008831 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 478433008832 [4Fe-4S] binding site [ion binding]; other site 478433008833 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 478433008834 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 478433008835 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 478433008836 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 478433008837 4Fe-4S binding domain; Region: Fer4; pfam00037 478433008838 4Fe-4S binding domain; Region: Fer4; pfam00037 478433008839 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 478433008840 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 478433008841 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 478433008842 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 478433008843 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 478433008844 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 478433008845 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 478433008846 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 478433008847 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 478433008848 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478433008849 PPE family; Region: PPE; pfam00823 478433008850 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478433008851 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 478433008852 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478433008853 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 478433008854 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 478433008855 [2Fe-2S] cluster binding site [ion binding]; other site 478433008856 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_1; cd08885 478433008857 putative alpha subunit interface [polypeptide binding]; other site 478433008858 putative active site [active] 478433008859 putative substrate binding site [chemical binding]; other site 478433008860 Fe binding site [ion binding]; other site 478433008861 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 478433008862 Protein of unknown function DUF58; Region: DUF58; pfam01882 478433008863 MoxR-like ATPases [General function prediction only]; Region: COG0714 478433008864 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 478433008865 Walker A motif; other site 478433008866 ATP binding site [chemical binding]; other site 478433008867 Walker B motif; other site 478433008868 arginine finger; other site 478433008869 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 478433008870 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 478433008871 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478433008872 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 478433008873 putative active site [active] 478433008874 putative substrate binding site [chemical binding]; other site 478433008875 ATP binding site [chemical binding]; other site 478433008876 Phosphotransferase enzyme family; Region: APH; pfam01636 478433008877 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 478433008878 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 478433008879 hydroxyglutarate oxidase; Provisional; Region: PRK11728 478433008880 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 478433008881 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 478433008882 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 478433008883 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478433008884 short chain dehydrogenase; Validated; Region: PRK08264 478433008885 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 478433008886 NAD(P) binding site [chemical binding]; other site 478433008887 active site 478433008888 amidase; Provisional; Region: PRK06170 478433008889 Amidase; Region: Amidase; pfam01425 478433008890 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 478433008891 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 478433008892 TAP-like protein; Region: Abhydrolase_4; pfam08386 478433008893 Domain of unknown function (DUF385); Region: DUF385; pfam04075 478433008894 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 478433008895 AAA domain; Region: AAA_14; pfam13173 478433008896 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 478433008897 putative active site [active] 478433008898 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 478433008899 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4683 478433008900 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 478433008901 non-specific DNA binding site [nucleotide binding]; other site 478433008902 salt bridge; other site 478433008903 sequence-specific DNA binding site [nucleotide binding]; other site 478433008904 RES domain; Region: RES; pfam08808 478433008905 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 478433008906 Helix-turn-helix domain; Region: HTH_38; pfam13936 478433008907 Integrase core domain; Region: rve; pfam00665 478433008908 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 478433008909 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 478433008910 hypothetical protein; Validated; Region: PRK00068 478433008911 Uncharacterized conserved protein [Function unknown]; Region: COG1615 478433008912 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 478433008913 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 478433008914 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 478433008915 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 478433008916 Uncharacterized conserved protein [Function unknown]; Region: COG5282 478433008917 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 478433008918 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 478433008919 ABC1 family; Region: ABC1; pfam03109 478433008920 Phosphotransferase enzyme family; Region: APH; pfam01636 478433008921 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 478433008922 active site 478433008923 ATP binding site [chemical binding]; other site 478433008924 Transcription factor WhiB; Region: Whib; pfam02467 478433008925 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 478433008926 Part of AAA domain; Region: AAA_19; pfam13245 478433008927 Family description; Region: UvrD_C_2; pfam13538 478433008928 HRDC domain; Region: HRDC; pfam00570 478433008929 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 478433008930 catalytic residues [active] 478433008931 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 478433008932 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 478433008933 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 478433008934 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 478433008935 putative NADH binding site [chemical binding]; other site 478433008936 putative active site [active] 478433008937 nudix motif; other site 478433008938 putative metal binding site [ion binding]; other site 478433008939 Ion channel; Region: Ion_trans_2; pfam07885 478433008940 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 478433008941 TrkA-N domain; Region: TrkA_N; pfam02254 478433008942 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 478433008943 Part of AAA domain; Region: AAA_19; pfam13245 478433008944 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 478433008945 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 478433008946 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 478433008947 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 478433008948 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 478433008949 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 478433008950 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 478433008951 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 478433008952 active site 478433008953 DNA binding site [nucleotide binding] 478433008954 TIGR02569 family protein; Region: TIGR02569_actnb 478433008955 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 478433008956 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 478433008957 ATP binding site [chemical binding]; other site 478433008958 substrate interface [chemical binding]; other site 478433008959 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 478433008960 active site residue [active] 478433008961 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 478433008962 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 478433008963 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478433008964 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 478433008965 tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like; Region: MiaE_2; pfam13794 478433008966 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 478433008967 DEAD-like helicases superfamily; Region: DEXDc; smart00487 478433008968 ATP binding site [chemical binding]; other site 478433008969 Mg++ binding site [ion binding]; other site 478433008970 motif III; other site 478433008971 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 478433008972 nucleotide binding region [chemical binding]; other site 478433008973 ATP-binding site [chemical binding]; other site 478433008974 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 478433008975 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 478433008976 P-loop; other site 478433008977 Magnesium ion binding site [ion binding]; other site 478433008978 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 478433008979 Magnesium ion binding site [ion binding]; other site 478433008980 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 478433008981 catalytic core [active] 478433008982 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 478433008983 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 478433008984 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 478433008985 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 478433008986 Transcription factor WhiB; Region: Whib; pfam02467 478433008987 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 478433008988 PAS domain S-box; Region: sensory_box; TIGR00229 478433008989 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 478433008990 Histidine kinase; Region: HisKA_2; pfam07568 478433008991 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 478433008992 ATP binding site [chemical binding]; other site 478433008993 Mg2+ binding site [ion binding]; other site 478433008994 G-X-G motif; other site 478433008995 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 478433008996 carboxyltransferase (CT) interaction site; other site 478433008997 biotinylation site [posttranslational modification]; other site 478433008998 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; TIGR03988 478433008999 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 478433009000 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 478433009001 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 478433009002 DNA binding residues [nucleotide binding] 478433009003 short chain dehydrogenase; Provisional; Region: PRK08278 478433009004 human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762 478433009005 NAD(P) binding site [chemical binding]; other site 478433009006 homodimer interface [polypeptide binding]; other site 478433009007 active site 478433009008 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 478433009009 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 478433009010 putative deacylase active site [active] 478433009011 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 478433009012 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 478433009013 Coenzyme A binding pocket [chemical binding]; other site 478433009014 Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases; Region: APH_ChoK_like_1; cd05155 478433009015 Phosphotransferase enzyme family; Region: APH; pfam01636 478433009016 putative active site [active] 478433009017 putative substrate binding site [chemical binding]; other site 478433009018 ATP binding site [chemical binding]; other site 478433009019 Uncharacterized conserved protein [Function unknown]; Region: COG2135 478433009020 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 478433009021 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 478433009022 hinge; other site 478433009023 active site 478433009024 Predicted GTPases [General function prediction only]; Region: COG1162 478433009025 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 478433009026 GTPase/Zn-binding domain interface [polypeptide binding]; other site 478433009027 GTP/Mg2+ binding site [chemical binding]; other site 478433009028 G4 box; other site 478433009029 G5 box; other site 478433009030 G1 box; other site 478433009031 Switch I region; other site 478433009032 G2 box; other site 478433009033 G3 box; other site 478433009034 Switch II region; other site 478433009035 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 478433009036 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 478433009037 putative di-iron ligands [ion binding]; other site 478433009038 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 478433009039 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 478433009040 FAD binding pocket [chemical binding]; other site 478433009041 FAD binding motif [chemical binding]; other site 478433009042 phosphate binding motif [ion binding]; other site 478433009043 beta-alpha-beta structure motif; other site 478433009044 NAD binding pocket [chemical binding]; other site 478433009045 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 478433009046 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 478433009047 catalytic loop [active] 478433009048 iron binding site [ion binding]; other site 478433009049 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 478433009050 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 478433009051 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 478433009052 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 478433009053 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 478433009054 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 478433009055 TrkA-C domain; Region: TrkA_C; pfam02080 478433009056 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 478433009057 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 478433009058 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 478433009059 putative substrate translocation pore; other site 478433009060 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 478433009061 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 478433009062 ligand binding site [chemical binding]; other site 478433009063 flexible hinge region; other site 478433009064 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 478433009065 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 478433009066 nucleophile elbow; other site 478433009067 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 478433009068 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 478433009069 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 478433009070 30S subunit binding site; other site 478433009071 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 478433009072 active site 478433009073 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 478433009074 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 478433009075 lipoprotein LpqB; Provisional; Region: PRK13616 478433009076 Sporulation and spore germination; Region: Germane; pfam10646 478433009077 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 478433009078 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 478433009079 dimerization interface [polypeptide binding]; other site 478433009080 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 478433009081 dimer interface [polypeptide binding]; other site 478433009082 phosphorylation site [posttranslational modification] 478433009083 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 478433009084 ATP binding site [chemical binding]; other site 478433009085 Mg2+ binding site [ion binding]; other site 478433009086 G-X-G motif; other site 478433009087 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 478433009088 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 478433009089 active site 478433009090 phosphorylation site [posttranslational modification] 478433009091 intermolecular recognition site; other site 478433009092 dimerization interface [polypeptide binding]; other site 478433009093 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 478433009094 DNA binding site [nucleotide binding] 478433009095 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 478433009096 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 478433009097 TMP-binding site; other site 478433009098 ATP-binding site [chemical binding]; other site 478433009099 Adenosylhomocysteinase; Provisional; Region: PTZ00075 478433009100 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 478433009101 homotetramer interface [polypeptide binding]; other site 478433009102 ligand binding site [chemical binding]; other site 478433009103 catalytic site [active] 478433009104 NAD binding site [chemical binding]; other site 478433009105 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478433009106 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 478433009107 Rubredoxin [Energy production and conversion]; Region: COG1773 478433009108 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 478433009109 iron binding site [ion binding]; other site 478433009110 Rubredoxin [Energy production and conversion]; Region: COG1773 478433009111 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 478433009112 iron binding site [ion binding]; other site 478433009113 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 478433009114 Fatty acid desaturase; Region: FA_desaturase; pfam00487 478433009115 Di-iron ligands [ion binding]; other site 478433009116 amino acid transporter; Region: 2A0306; TIGR00909 478433009117 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 478433009118 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 478433009119 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 478433009120 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 478433009121 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 478433009122 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 478433009123 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 478433009124 active site 478433009125 substrate binding site [chemical binding]; other site 478433009126 metal binding site [ion binding]; metal-binding site 478433009127 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 478433009128 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 478433009129 Transcription factor WhiB; Region: Whib; pfam02467 478433009130 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 478433009131 LPPG:FO 2-phospho-L-lactate transferase; important in F420 biosynthesis; Region: CofD_like; cd07186 478433009132 phosphate binding site [ion binding]; other site 478433009133 dimer interface [polypeptide binding]; other site 478433009134 substrate binding site [chemical binding]; other site 478433009135 F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294 478433009136 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 478433009137 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 478433009138 putative FMN binding site [chemical binding]; other site 478433009139 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 478433009140 Methyltransferase domain; Region: Methyltransf_26; pfam13659 478433009141 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 478433009142 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 478433009143 active site 478433009144 Substrate binding site; other site 478433009145 Mg++ binding site; other site 478433009146 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 478433009147 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 478433009148 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 478433009149 Probable Catalytic site; other site 478433009150 metal-binding site 478433009151 dTDP-4-dehydrorhamnose reductase; Region: rmlD; TIGR01214 478433009152 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 478433009153 NADP binding site [chemical binding]; other site 478433009154 active site 478433009155 putative substrate binding site [chemical binding]; other site 478433009156 Transcriptional regulator [Transcription]; Region: LytR; COG1316 478433009157 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 478433009158 TIGR03089 family protein; Region: TIGR03089 478433009159 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 478433009160 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 478433009161 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 478433009162 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 478433009163 active site 478433009164 motif I; other site 478433009165 motif II; other site 478433009166 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 478433009167 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 478433009168 CoA-transferase family III; Region: CoA_transf_3; pfam02515 478433009169 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 478433009170 Sulfate transporter family; Region: Sulfate_transp; pfam00916 478433009171 Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: CynT; COG0288 478433009172 active site clefts [active] 478433009173 zinc binding site [ion binding]; other site 478433009174 dimer interface [polypeptide binding]; other site 478433009175 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 478433009176 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 478433009177 FAD binding site [chemical binding]; other site 478433009178 homotetramer interface [polypeptide binding]; other site 478433009179 substrate binding pocket [chemical binding]; other site 478433009180 catalytic base [active] 478433009181 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 478433009182 Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase) [Nucleotide transport and metabolism]; Region: PurK; COG0026 478433009183 ATP-grasp domain; Region: ATP-grasp; pfam02222 478433009184 Predicted membrane protein [Function unknown]; Region: COG2246 478433009185 GtrA-like protein; Region: GtrA; pfam04138 478433009186 Bacterial PH domain; Region: DUF304; pfam03703 478433009187 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 478433009188 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 478433009189 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 478433009190 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 478433009191 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 478433009192 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 478433009193 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 478433009194 Maf-like protein; Region: Maf; pfam02545 478433009195 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 478433009196 active site 478433009197 dimer interface [polypeptide binding]; other site 478433009198 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 478433009199 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 478433009200 active site residue [active] 478433009201 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 478433009202 active site residue [active] 478433009203 Fe-S metabolism associated domain; Region: SufE; pfam02657 478433009204 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 478433009205 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 478433009206 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 478433009207 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 478433009208 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 478433009209 carboxyltransferase (CT) interaction site; other site 478433009210 biotinylation site [posttranslational modification]; other site 478433009211 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122 478433009212 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 478433009213 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 478433009214 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 478433009215 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 478433009216 L-lysine aminotransferase; Provisional; Region: PRK08297 478433009217 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 478433009218 inhibitor-cofactor binding pocket; inhibition site 478433009219 pyridoxal 5'-phosphate binding site [chemical binding]; other site 478433009220 catalytic residue [active] 478433009221 putative DNA binding site [nucleotide binding]; other site 478433009222 dimerization interface [polypeptide binding]; other site 478433009223 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 478433009224 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 478433009225 putative Zn2+ binding site [ion binding]; other site 478433009226 AsnC family; Region: AsnC_trans_reg; pfam01037 478433009227 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 478433009228 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 478433009229 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 478433009230 tetrameric interface [polypeptide binding]; other site 478433009231 NAD binding site [chemical binding]; other site 478433009232 catalytic residues [active] 478433009233 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 478433009234 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 478433009235 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478433009236 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 478433009237 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 478433009238 ATP binding site [chemical binding]; other site 478433009239 putative Mg++ binding site [ion binding]; other site 478433009240 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 478433009241 nucleotide binding region [chemical binding]; other site 478433009242 ATP-binding site [chemical binding]; other site 478433009243 DEAD/H associated; Region: DEAD_assoc; pfam08494 478433009244 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 478433009245 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 478433009246 putative DNA binding site [nucleotide binding]; other site 478433009247 catalytic residue [active] 478433009248 putative H2TH interface [polypeptide binding]; other site 478433009249 putative catalytic residues [active] 478433009250 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 478433009251 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 478433009252 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 478433009253 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 478433009254 Sulfatase; Region: Sulfatase; pfam00884 478433009255 Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558 478433009256 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 478433009257 probable active site [active] 478433009258 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 478433009259 PhoU domain; Region: PhoU; pfam01895 478433009260 PhoU domain; Region: PhoU; pfam01895 478433009261 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 478433009262 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 478433009263 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 478433009264 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 478433009265 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 478433009266 putative active site pocket [active] 478433009267 dimerization interface [polypeptide binding]; other site 478433009268 putative catalytic residue [active] 478433009269 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 478433009270 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 478433009271 metal binding site [ion binding]; metal-binding site 478433009272 putative dimer interface [polypeptide binding]; other site 478433009273 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 478433009274 amidohydrolase; Region: amidohydrolases; TIGR01891 478433009275 metal binding site [ion binding]; metal-binding site 478433009276 purine nucleoside phosphorylase; Provisional; Region: PRK08202 478433009277 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 478433009278 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 478433009279 active site 478433009280 substrate binding site [chemical binding]; other site 478433009281 metal binding site [ion binding]; metal-binding site 478433009282 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 478433009283 active site 478433009284 Phosphoesterase family; Region: Phosphoesterase; pfam04185 478433009285 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 478433009286 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 478433009287 adenosine deaminase; Provisional; Region: PRK09358 478433009288 active site 478433009289 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 478433009290 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 478433009291 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 478433009292 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 478433009293 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 478433009294 active site 478433009295 catalytic motif [active] 478433009296 Zn binding site [ion binding]; other site 478433009297 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 478433009298 putative Iron-sulfur protein interface [polypeptide binding]; other site 478433009299 putative proximal heme binding site [chemical binding]; other site 478433009300 putative SdhD-like interface [polypeptide binding]; other site 478433009301 putative distal heme binding site [chemical binding]; other site 478433009302 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 478433009303 putative Iron-sulfur protein interface [polypeptide binding]; other site 478433009304 putative proximal heme binding site [chemical binding]; other site 478433009305 putative SdhC-like subunit interface [polypeptide binding]; other site 478433009306 putative distal heme binding site [chemical binding]; other site 478433009307 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 478433009308 L-aspartate oxidase; Provisional; Region: PRK06175 478433009309 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 478433009310 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 478433009311 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 478433009312 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 478433009313 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 478433009314 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478433009315 S-adenosylmethionine binding site [chemical binding]; other site 478433009316 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 478433009317 MoaE interaction surface [polypeptide binding]; other site 478433009318 MoeB interaction surface [polypeptide binding]; other site 478433009319 thiocarboxylated glycine; other site 478433009320 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 478433009321 MoaE homodimer interface [polypeptide binding]; other site 478433009322 MoaD interaction [polypeptide binding]; other site 478433009323 active site residues [active] 478433009324 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 478433009325 trimer interface [polypeptide binding]; other site 478433009326 dimer interface [polypeptide binding]; other site 478433009327 putative active site [active] 478433009328 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 478433009329 aromatic arch; other site 478433009330 DCoH dimer interaction site [polypeptide binding]; other site 478433009331 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 478433009332 DCoH tetramer interaction site [polypeptide binding]; other site 478433009333 substrate binding site [chemical binding]; other site 478433009334 putative transposase OrfB; Reviewed; Region: PHA02517 478433009335 HTH-like domain; Region: HTH_21; pfam13276 478433009336 Integrase core domain; Region: rve; pfam00665 478433009337 Integrase core domain; Region: rve_3; pfam13683 478433009338 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 478433009339 Transposase; Region: HTH_Tnp_1; cl17663 478433009340 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 478433009341 hypothetical protein; Provisional; Region: PRK06541 478433009342 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 478433009343 inhibitor-cofactor binding pocket; inhibition site 478433009344 pyridoxal 5'-phosphate binding site [chemical binding]; other site 478433009345 catalytic residue [active] 478433009346 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 478433009347 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 478433009348 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 478433009349 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 478433009350 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 478433009351 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 478433009352 active site 478433009353 dimer interface [polypeptide binding]; other site 478433009354 Protein of unknown function (DUF732); Region: DUF732; pfam05305 478433009355 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 478433009356 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 478433009357 DNA binding residues [nucleotide binding] 478433009358 dimer interface [polypeptide binding]; other site 478433009359 metal binding site [ion binding]; metal-binding site 478433009360 inner membrane protein YhjD; Region: TIGR00766 478433009361 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 478433009362 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 478433009363 active site 478433009364 HIGH motif; other site 478433009365 dimer interface [polypeptide binding]; other site 478433009366 KMSKS motif; other site 478433009367 acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875 478433009368 isocitrate dehydrogenase; Validated; Region: PRK08299 478433009369 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 478433009370 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 478433009371 homodimer interface [polypeptide binding]; other site 478433009372 substrate-cofactor binding pocket; other site 478433009373 pyridoxal 5'-phosphate binding site [chemical binding]; other site 478433009374 catalytic residue [active] 478433009375 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 478433009376 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 478433009377 Methyltransferase domain; Region: Methyltransf_23; pfam13489 478433009378 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478433009379 S-adenosylmethionine binding site [chemical binding]; other site 478433009380 PPE family; Region: PPE; pfam00823 478433009381 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478433009382 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478433009383 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478433009384 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478433009385 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478433009386 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478433009387 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478433009388 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478433009389 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478433009390 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478433009391 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478433009392 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478433009393 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478433009394 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478433009395 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478433009396 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478433009397 PE family; Region: PE; pfam00934 478433009398 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 478433009399 PPE family; Region: PPE; pfam00823 478433009400 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478433009401 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478433009402 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478433009403 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478433009404 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478433009405 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478433009406 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478433009407 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478433009408 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478433009409 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478433009410 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478433009411 Transposase; Region: DEDD_Tnp_IS110; pfam01548 478433009412 Transposase; Region: DDE_Tnp_ISL3; pfam01610 478433009413 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478433009414 PPE family; Region: PPE; pfam00823 478433009415 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478433009416 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478433009417 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478433009418 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478433009419 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478433009420 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478433009421 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478433009422 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478433009423 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478433009424 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478433009425 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478433009426 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478433009427 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478433009428 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478433009429 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478433009430 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478433009431 Berberine and berberine like; Region: BBE; pfam08031 478433009432 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 478433009433 Protein of unknown function (DUF732); Region: DUF732; pfam05305 478433009434 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 478433009435 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 478433009436 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 478433009437 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 478433009438 homodimer interface [polypeptide binding]; other site 478433009439 NADP binding site [chemical binding]; other site 478433009440 substrate binding site [chemical binding]; other site 478433009441 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 478433009442 Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769 478433009443 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 478433009444 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 478433009445 active site 478433009446 FMN binding site [chemical binding]; other site 478433009447 substrate binding site [chemical binding]; other site 478433009448 putative catalytic residue [active] 478433009449 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 478433009450 phosphate binding site [ion binding]; other site 478433009451 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 478433009452 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 478433009453 phosphopeptide binding site; other site 478433009454 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 478433009455 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 478433009456 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 478433009457 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 478433009458 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 478433009459 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 478433009460 G1 box; other site 478433009461 GTP/Mg2+ binding site [chemical binding]; other site 478433009462 G2 box; other site 478433009463 Switch I region; other site 478433009464 G3 box; other site 478433009465 Switch II region; other site 478433009466 G4 box; other site 478433009467 G5 box; other site 478433009468 Protein of unknown function (DUF742); Region: DUF742; pfam05331 478433009469 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 478433009470 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 478433009471 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 478433009472 ATP binding site [chemical binding]; other site 478433009473 Mg2+ binding site [ion binding]; other site 478433009474 G-X-G motif; other site 478433009475 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 478433009476 PE family; Region: PE; pfam00934 478433009477 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 478433009478 FMN binding site [chemical binding]; other site 478433009479 dimer interface [polypeptide binding]; other site 478433009480 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 478433009481 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 478433009482 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 478433009483 active site 478433009484 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 478433009485 generic binding surface II; other site 478433009486 generic binding surface I; other site 478433009487 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 478433009488 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 478433009489 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 478433009490 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 478433009491 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 478433009492 active site 478433009493 motif I; other site 478433009494 motif II; other site 478433009495 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 478433009496 substrate binding site [chemical binding]; other site 478433009497 oxyanion hole (OAH) forming residues; other site 478433009498 trimer interface [polypeptide binding]; other site 478433009499 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 478433009500 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 478433009501 Amidase; Region: Amidase; pfam01425 478433009502 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 478433009503 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 478433009504 motif II; other site 478433009505 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 478433009506 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 478433009507 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 478433009508 TPP-binding site [chemical binding]; other site 478433009509 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 478433009510 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 478433009511 PYR/PP interface [polypeptide binding]; other site 478433009512 dimer interface [polypeptide binding]; other site 478433009513 TPP binding site [chemical binding]; other site 478433009514 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 478433009515 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 478433009516 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 478433009517 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 478433009518 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 478433009519 substrate binding pocket [chemical binding]; other site 478433009520 chain length determination region; other site 478433009521 substrate-Mg2+ binding site; other site 478433009522 catalytic residues [active] 478433009523 aspartate-rich region 1; other site 478433009524 active site lid residues [active] 478433009525 aspartate-rich region 2; other site 478433009526 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 478433009527 putative active site [active] 478433009528 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 478433009529 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 478433009530 Transposase domain (DUF772); Region: DUF772; pfam05598 478433009531 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 478433009532 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 478433009533 PE family; Region: PE; pfam00934 478433009534 enoyl-CoA hydratase; Region: PLN02864 478433009535 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 478433009536 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 478433009537 dimer interaction site [polypeptide binding]; other site 478433009538 substrate-binding tunnel; other site 478433009539 active site 478433009540 catalytic site [active] 478433009541 substrate binding site [chemical binding]; other site 478433009542 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 478433009543 short chain dehydrogenase; Provisional; Region: PRK07201 478433009544 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 478433009545 putative NAD(P) binding site [chemical binding]; other site 478433009546 active site 478433009547 putative substrate binding site [chemical binding]; other site 478433009548 classical (c) SDRs; Region: SDR_c; cd05233 478433009549 NAD(P) binding site [chemical binding]; other site 478433009550 active site 478433009551 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 478433009552 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478433009553 S-adenosylmethionine binding site [chemical binding]; other site 478433009554 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 478433009555 active site 478433009556 DNA Polymerase Y-family; Region: PolY_like; cd03468 478433009557 DNA binding site [nucleotide binding] 478433009558 GMP synthase; Reviewed; Region: guaA; PRK00074 478433009559 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 478433009560 AMP/PPi binding site [chemical binding]; other site 478433009561 candidate oxyanion hole; other site 478433009562 catalytic triad [active] 478433009563 potential glutamine specificity residues [chemical binding]; other site 478433009564 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 478433009565 ATP Binding subdomain [chemical binding]; other site 478433009566 Ligand Binding sites [chemical binding]; other site 478433009567 Dimerization subdomain; other site 478433009568 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 478433009569 active site lid residues [active] 478433009570 substrate binding pocket [chemical binding]; other site 478433009571 catalytic residues [active] 478433009572 substrate-Mg2+ binding site; other site 478433009573 aspartate-rich region 1; other site 478433009574 aspartate-rich region 2; other site 478433009575 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 478433009576 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 478433009577 substrate binding pocket [chemical binding]; other site 478433009578 chain length determination region; other site 478433009579 substrate-Mg2+ binding site; other site 478433009580 catalytic residues [active] 478433009581 aspartate-rich region 1; other site 478433009582 active site lid residues [active] 478433009583 aspartate-rich region 2; other site 478433009584 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 478433009585 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 478433009586 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 478433009587 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 478433009588 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 478433009589 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 478433009590 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 478433009591 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 478433009592 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 478433009593 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 478433009594 inhibitor-cofactor binding pocket; inhibition site 478433009595 pyridoxal 5'-phosphate binding site [chemical binding]; other site 478433009596 catalytic residue [active] 478433009597 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 478433009598 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 478433009599 hypothetical protein; Provisional; Region: PRK07579 478433009600 Formyltransferase, catalytic core domain; Region: FMT_core; cd08369 478433009601 active site 478433009602 cosubstrate binding site; other site 478433009603 substrate binding site [chemical binding]; other site 478433009604 catalytic site [active] 478433009605 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 478433009606 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478433009607 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 478433009608 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 478433009609 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 478433009610 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 478433009611 putative active site [active] 478433009612 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 478433009613 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 478433009614 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 478433009615 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 478433009616 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 478433009617 phosphate binding site [ion binding]; other site 478433009618 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 478433009619 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 478433009620 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 478433009621 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 478433009622 active site 478433009623 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 478433009624 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 478433009625 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 478433009626 DNA binding residues [nucleotide binding] 478433009627 Transcription factor WhiB; Region: Whib; pfam02467 478433009628 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 478433009629 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 478433009630 ring oligomerisation interface [polypeptide binding]; other site 478433009631 ATP/Mg binding site [chemical binding]; other site 478433009632 stacking interactions; other site 478433009633 hinge regions; other site 478433009634 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 478433009635 oligomerisation interface [polypeptide binding]; other site 478433009636 mobile loop; other site 478433009637 roof hairpin; other site 478433009638 UGMP family protein; Validated; Region: PRK09604 478433009639 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 478433009640 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 478433009641 Coenzyme A binding pocket [chemical binding]; other site 478433009642 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 478433009643 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; pfam02367 478433009644 alanine racemase; Reviewed; Region: alr; PRK00053 478433009645 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 478433009646 active site 478433009647 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 478433009648 dimer interface [polypeptide binding]; other site 478433009649 substrate binding site [chemical binding]; other site 478433009650 catalytic residues [active] 478433009651 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478433009652 PPE family; Region: PPE; pfam00823 478433009653 Integrase core domain; Region: rve; pfam00665 478433009654 Integrase core domain; Region: rve_3; pfam13683 478433009655 Transposase, Mutator family; Region: Transposase_mut; pfam00872 478433009656 MULE transposase domain; Region: MULE; pfam10551 478433009657 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 478433009658 pyridoxal 5'-phosphate binding site [chemical binding]; other site 478433009659 catalytic residue [active] 478433009660 Uncharacterized conserved protein [Function unknown]; Region: COG0062 478433009661 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 478433009662 putative substrate binding site [chemical binding]; other site 478433009663 putative ATP binding site [chemical binding]; other site 478433009664 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 478433009665 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 478433009666 glutaminase active site [active] 478433009667 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 478433009668 dimer interface [polypeptide binding]; other site 478433009669 active site 478433009670 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 478433009671 dimer interface [polypeptide binding]; other site 478433009672 active site 478433009673 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 478433009674 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 478433009675 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 478433009676 active site 478433009677 substrate binding site [chemical binding]; other site 478433009678 metal binding site [ion binding]; metal-binding site 478433009679 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 478433009680 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 478433009681 23S rRNA interface [nucleotide binding]; other site 478433009682 L3 interface [polypeptide binding]; other site 478433009683 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 478433009684 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 478433009685 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 478433009686 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 478433009687 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 478433009688 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 478433009689 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 478433009690 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 478433009691 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 478433009692 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 478433009693 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 478433009694 active site 478433009695 catalytic residues [active] 478433009696 Protein of unknown function (DUF690); Region: DUF690; cl04939 478433009697 Cutinase; Region: Cutinase; pfam01083 478433009698 Cutinase; Region: Cutinase; pfam01083 478433009699 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 478433009700 Pseudouridylate synthase [Translation, ribosomal structure and biogenesis]; Region: TruA; COG0101 478433009701 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 478433009702 dimerization interface 3.5A [polypeptide binding]; other site 478433009703 active site 478433009704 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 478433009705 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 478433009706 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 478433009707 alphaNTD - beta interaction site [polypeptide binding]; other site 478433009708 alphaNTD homodimer interface [polypeptide binding]; other site 478433009709 alphaNTD - beta' interaction site [polypeptide binding]; other site 478433009710 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 478433009711 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 478433009712 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 478433009713 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 478433009714 RNA binding surface [nucleotide binding]; other site 478433009715 30S ribosomal protein S11; Validated; Region: PRK05309 478433009716 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 478433009717 30S ribosomal protein S13; Region: bact_S13; TIGR03631 478433009718 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 478433009719 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 478433009720 rRNA binding site [nucleotide binding]; other site 478433009721 predicted 30S ribosome binding site; other site 478433009722 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 478433009723 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 478433009724 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 478433009725 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 478433009726 NAD binding site [chemical binding]; other site 478433009727 substrate binding site [chemical binding]; other site 478433009728 homodimer interface [polypeptide binding]; other site 478433009729 active site 478433009730 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 478433009731 Domain of unknown function (DUF222); Region: DUF222; pfam02720 478433009732 Domain of unknown function (DUF222); Region: DUF222; pfam02720 478433009733 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 478433009734 active site 478433009735 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 478433009736 extended (e) SDRs; Region: SDR_e; cd08946 478433009737 NAD(P) binding site [chemical binding]; other site 478433009738 active site 478433009739 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 478433009740 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 478433009741 active site 478433009742 catalytic residues [active] 478433009743 metal binding site [ion binding]; metal-binding site 478433009744 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 478433009745 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 478433009746 PYR/PP interface [polypeptide binding]; other site 478433009747 dimer interface [polypeptide binding]; other site 478433009748 TPP binding site [chemical binding]; other site 478433009749 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 478433009750 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 478433009751 TPP-binding site [chemical binding]; other site 478433009752 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 478433009753 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 478433009754 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 478433009755 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 478433009756 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 478433009757 metabolite-proton symporter; Region: 2A0106; TIGR00883 478433009758 putative substrate translocation pore; other site 478433009759 PE family; Region: PE; pfam00934 478433009760 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478433009761 PPE family; Region: PPE; pfam00823 478433009762 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 478433009763 patatin-related protein; Region: TIGR03607 478433009764 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 478433009765 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 478433009766 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 478433009767 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 478433009768 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 478433009769 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 478433009770 Transcriptional regulator [Transcription]; Region: LytR; COG1316 478433009771 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 478433009772 short chain dehydrogenase; Provisional; Region: PRK05875 478433009773 classical (c) SDRs; Region: SDR_c; cd05233 478433009774 NAD(P) binding site [chemical binding]; other site 478433009775 active site 478433009776 Predicted membrane protein [Function unknown]; Region: COG2259 478433009777 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 478433009778 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 478433009779 Predicted transcriptional regulators [Transcription]; Region: COG1695 478433009780 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 478433009781 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 478433009782 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 478433009783 active site 478433009784 homotetramer interface [polypeptide binding]; other site 478433009785 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 478433009786 mce related protein; Region: MCE; pfam02470 478433009787 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 478433009788 mce related protein; Region: MCE; pfam02470 478433009789 mce related protein; Region: MCE; pfam02470 478433009790 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 478433009791 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 478433009792 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 478433009793 mce related protein; Region: MCE; pfam02470 478433009794 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 478433009795 mce related protein; Region: MCE; pfam02470 478433009796 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 478433009797 mce related protein; Region: MCE; pfam02470 478433009798 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 478433009799 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 478433009800 Permease; Region: Permease; pfam02405 478433009801 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 478433009802 Permease; Region: Permease; pfam02405 478433009803 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07792 478433009804 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 478433009805 NAD(P) binding site [chemical binding]; other site 478433009806 active site 478433009807 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 478433009808 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 478433009809 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 478433009810 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 478433009811 FAD binding site [chemical binding]; other site 478433009812 substrate binding site [chemical binding]; other site 478433009813 catalytic base [active] 478433009814 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 478433009815 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 478433009816 active site 478433009817 acyl-CoA synthetase; Validated; Region: PRK07867 478433009818 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 478433009819 acyl-activating enzyme (AAE) consensus motif; other site 478433009820 putative AMP binding site [chemical binding]; other site 478433009821 putative active site [active] 478433009822 putative CoA binding site [chemical binding]; other site 478433009823 PE family; Region: PE; pfam00934 478433009824 PE family; Region: PE; pfam00934 478433009825 hypothetical protein; Validated; Region: PRK07586 478433009826 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 478433009827 PYR/PP interface [polypeptide binding]; other site 478433009828 dimer interface [polypeptide binding]; other site 478433009829 TPP binding site [chemical binding]; other site 478433009830 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 478433009831 TPP-binding site [chemical binding]; other site 478433009832 dimer interface [polypeptide binding]; other site 478433009833 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 478433009834 PE family; Region: PE; pfam00934 478433009835 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 478433009836 CoA binding site [chemical binding]; other site 478433009837 PE family; Region: PE; pfam00934 478433009838 acyl-CoA synthetase; Validated; Region: PRK07798 478433009839 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 478433009840 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 478433009841 acyl-activating enzyme (AAE) consensus motif; other site 478433009842 acyl-activating enzyme (AAE) consensus motif; other site 478433009843 putative AMP binding site [chemical binding]; other site 478433009844 putative active site [active] 478433009845 putative CoA binding site [chemical binding]; other site 478433009846 enoyl-CoA hydratase; Provisional; Region: PRK07799 478433009847 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 478433009848 substrate binding site [chemical binding]; other site 478433009849 oxyanion hole (OAH) forming residues; other site 478433009850 trimer interface [polypeptide binding]; other site 478433009851 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 478433009852 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 478433009853 Cytochrome P450; Region: p450; cl12078 478433009854 Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314 478433009855 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 478433009856 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 478433009857 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 478433009858 DUF35 OB-fold domain; Region: DUF35; pfam01796 478433009859 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 478433009860 DUF35 OB-fold domain; Region: DUF35; pfam01796 478433009861 lipid-transfer protein; Provisional; Region: PRK07937 478433009862 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 478433009863 active site 478433009864 acetyl-CoA acetyltransferase; Provisional; Region: PRK08313 478433009865 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 478433009866 active site 478433009867 NHL repeat; Region: NHL; pfam01436 478433009868 Uncharacterized conserved protein [Function unknown]; Region: COG3391 478433009869 NHL repeat; Region: NHL; pfam01436 478433009870 NHL repeat; Region: NHL; pfam01436 478433009871 NHL repeat; Region: NHL; pfam01436 478433009872 NHL repeat; Region: NHL; pfam01436 478433009873 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 478433009874 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 478433009875 trimer interface [polypeptide binding]; other site 478433009876 putative metal binding site [ion binding]; other site 478433009877 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 478433009878 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 478433009879 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 478433009880 short chain dehydrogenase; Provisional; Region: PRK07890 478433009881 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 478433009882 NAD(P) binding site [chemical binding]; other site 478433009883 active site 478433009884 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478433009885 PPE family; Region: PPE; pfam00823 478433009886 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 478433009887 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478433009888 PPE family; Region: PPE; pfam00823 478433009889 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478433009890 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478433009891 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 478433009892 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 478433009893 active site 478433009894 catalytic residues [active] 478433009895 metal binding site [ion binding]; metal-binding site 478433009896 DmpG-like communication domain; Region: DmpG_comm; pfam07836 478433009897 acetaldehyde dehydrogenase; Validated; Region: PRK08300 478433009898 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 478433009899 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 478433009900 2-keto-4-pentenoate hydratase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3971 478433009901 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843 478433009902 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 478433009903 enoyl-CoA hydratase; Region: PLN02864 478433009904 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 478433009905 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 478433009906 dimer interaction site [polypeptide binding]; other site 478433009907 substrate-binding tunnel; other site 478433009908 active site 478433009909 catalytic site [active] 478433009910 substrate binding site [chemical binding]; other site 478433009911 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478433009912 PPE family; Region: PPE; pfam00823 478433009913 PE-PPE domain; Region: PE-PPE; pfam08237 478433009914 lipid-transfer protein; Provisional; Region: PRK07855 478433009915 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 478433009916 active site 478433009917 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 478433009918 putative active site [active] 478433009919 putative catalytic site [active] 478433009920 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 478433009921 active site 478433009922 catalytic site [active] 478433009923 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 478433009924 DUF35 OB-fold domain; Region: DUF35; pfam01796 478433009925 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 478433009926 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 478433009927 active site 478433009928 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 478433009929 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 478433009930 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 478433009931 active site 478433009932 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 478433009933 Cytochrome P450; Region: p450; cl12078 478433009934 acetyl-CoA acetyltransferase; Provisional; Region: PRK07850 478433009935 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 478433009936 dimer interface [polypeptide binding]; other site 478433009937 active site 478433009938 Domain of unknown function (DUF385); Region: DUF385; pfam04075 478433009939 short chain dehydrogenase; Provisional; Region: PRK07791 478433009940 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 478433009941 homodimer interface [polypeptide binding]; other site 478433009942 NAD binding site [chemical binding]; other site 478433009943 active site 478433009944 short chain dehydrogenase; Provisional; Region: PRK07856 478433009945 classical (c) SDRs; Region: SDR_c; cd05233 478433009946 NAD(P) binding site [chemical binding]; other site 478433009947 active site 478433009948 enoyl-CoA hydratase; Provisional; Region: PRK06495 478433009949 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 478433009950 substrate binding site [chemical binding]; other site 478433009951 oxyanion hole (OAH) forming residues; other site 478433009952 trimer interface [polypeptide binding]; other site 478433009953 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 478433009954 Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit [Lipid metabolism]; Region: AtoA; COG2057 478433009955 Nitronate monooxygenase; Region: NMO; pfam03060 478433009956 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 478433009957 FMN binding site [chemical binding]; other site 478433009958 substrate binding site [chemical binding]; other site 478433009959 putative catalytic residue [active] 478433009960 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 478433009961 Beta-carotene hydroxylase (CrtR), the carotenoid zeaxanthin biosynthetic enzyme catalyzes the addition of hydroxyl groups to the beta-ionone rings of beta-carotene to form zeaxanthin and is found in bacteria and red algae. Carotenoids are important...; Region: CrtR_beta-carotene-hydroxylase; cd03514 478433009962 putative di-iron ligands [ion binding]; other site 478433009963 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 478433009964 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 478433009965 FAD binding pocket [chemical binding]; other site 478433009966 FAD binding motif [chemical binding]; other site 478433009967 phosphate binding motif [ion binding]; other site 478433009968 beta-alpha-beta structure motif; other site 478433009969 NAD(p) ribose binding residues [chemical binding]; other site 478433009970 NAD binding pocket [chemical binding]; other site 478433009971 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 478433009972 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 478433009973 catalytic loop [active] 478433009974 iron binding site [ion binding]; other site 478433009975 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 478433009976 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 478433009977 putative active site [active] 478433009978 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 478433009979 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 478433009980 dimer interface [polypeptide binding]; other site 478433009981 active site 478433009982 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 478433009983 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478433009984 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478433009985 PPE family; Region: PPE; pfam00823 478433009986 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 478433009987 short chain dehydrogenase; Provisional; Region: PRK07831 478433009988 classical (c) SDRs; Region: SDR_c; cd05233 478433009989 NAD(P) binding site [chemical binding]; other site 478433009990 active site 478433009991 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 478433009992 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 478433009993 active site 478433009994 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 478433009995 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 478433009996 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 478433009997 acyl-activating enzyme (AAE) consensus motif; other site 478433009998 putative AMP binding site [chemical binding]; other site 478433009999 putative active site [active] 478433010000 putative CoA binding site [chemical binding]; other site 478433010001 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 478433010002 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 478433010003 active site 478433010004 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 478433010005 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 478433010006 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 478433010007 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 478433010008 active site 478433010009 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 478433010010 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 478433010011 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 478433010012 active site 478433010013 aspartate aminotransferase; Provisional; Region: PRK05764 478433010014 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 478433010015 pyridoxal 5'-phosphate binding site [chemical binding]; other site 478433010016 homodimer interface [polypeptide binding]; other site 478433010017 catalytic residue [active] 478433010018 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 478433010019 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 478433010020 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 478433010021 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 478433010022 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 478433010023 active site 478433010024 Fe binding site [ion binding]; other site 478433010025 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 478433010026 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 478433010027 Naphthocyclinone hydroxylase; Region: NcnH; cd01159 478433010028 Flavin binding site [chemical binding]; other site 478433010029 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 478433010030 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 478433010031 FAD binding pocket [chemical binding]; other site 478433010032 FAD binding motif [chemical binding]; other site 478433010033 phosphate binding motif [ion binding]; other site 478433010034 beta-alpha-beta structure motif; other site 478433010035 NAD(p) ribose binding residues [chemical binding]; other site 478433010036 NAD binding pocket [chemical binding]; other site 478433010037 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 478433010038 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 478433010039 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 478433010040 catalytic loop [active] 478433010041 iron binding site [ion binding]; other site 478433010042 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 478433010043 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 478433010044 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 478433010045 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 478433010046 active site 478433010047 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 478433010048 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478433010049 Transcriptional regulators [Transcription]; Region: PurR; COG1609 478433010050 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 478433010051 DNA binding site [nucleotide binding] 478433010052 domain linker motif; other site 478433010053 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 478433010054 putative dimerization interface [polypeptide binding]; other site 478433010055 putative ligand binding site [chemical binding]; other site 478433010056 PknH-like extracellular domain; Region: PknH_C; pfam14032 478433010057 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 478433010058 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 478433010059 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 478433010060 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 478433010061 transmembrane helices; other site 478433010062 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 478433010063 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 478433010064 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 478433010065 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 478433010066 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 478433010067 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 478433010068 active site 478433010069 HIGH motif; other site 478433010070 nucleotide binding site [chemical binding]; other site 478433010071 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 478433010072 KMSKS motif; other site 478433010073 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 478433010074 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 478433010075 homotrimer interaction site [polypeptide binding]; other site 478433010076 zinc binding site [ion binding]; other site 478433010077 CDP-binding sites; other site 478433010078 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 478433010079 substrate binding site; other site 478433010080 dimer interface; other site 478433010081 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 478433010082 DNA repair protein RadA; Provisional; Region: PRK11823 478433010083 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 478433010084 Walker A motif/ATP binding site; other site 478433010085 ATP binding site [chemical binding]; other site 478433010086 Walker B motif; other site 478433010087 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 478433010088 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 478433010089 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 478433010090 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 478433010091 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 478433010092 active site clefts [active] 478433010093 zinc binding site [ion binding]; other site 478433010094 dimer interface [polypeptide binding]; other site 478433010095 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 478433010096 endonuclease III; Region: ENDO3c; smart00478 478433010097 minor groove reading motif; other site 478433010098 helix-hairpin-helix signature motif; other site 478433010099 substrate binding pocket [chemical binding]; other site 478433010100 active site 478433010101 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 478433010102 PE family; Region: PE; pfam00934 478433010103 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 478433010104 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 478433010105 catalytic site [active] 478433010106 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 478433010107 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 478433010108 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 478433010109 Ami_2 domain; Region: Ami_2; smart00644 478433010110 amidase catalytic site [active] 478433010111 Zn binding residues [ion binding]; other site 478433010112 substrate binding site [chemical binding]; other site 478433010113 PE family; Region: PE; pfam00934 478433010114 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 478433010115 Clp amino terminal domain; Region: Clp_N; pfam02861 478433010116 Clp amino terminal domain; Region: Clp_N; pfam02861 478433010117 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 478433010118 Walker A motif; other site 478433010119 ATP binding site [chemical binding]; other site 478433010120 Walker B motif; other site 478433010121 arginine finger; other site 478433010122 UvrB/uvrC motif; Region: UVR; pfam02151 478433010123 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 478433010124 Walker A motif; other site 478433010125 ATP binding site [chemical binding]; other site 478433010126 Walker B motif; other site 478433010127 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 478433010128 Lsr2; Region: Lsr2; pfam11774 478433010129 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 478433010130 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 478433010131 dimer interface [polypeptide binding]; other site 478433010132 putative anticodon binding site; other site 478433010133 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 478433010134 motif 1; other site 478433010135 dimer interface [polypeptide binding]; other site 478433010136 active site 478433010137 motif 2; other site 478433010138 motif 3; other site 478433010139 pantothenate kinase; Reviewed; Region: PRK13318 478433010140 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 478433010141 tetramerization interface [polypeptide binding]; other site 478433010142 active site 478433010143 Pantoate-beta-alanine ligase; Region: PanC; cd00560 478433010144 pantoate--beta-alanine ligase; Region: panC; TIGR00018 478433010145 active site 478433010146 ATP-binding site [chemical binding]; other site 478433010147 pantoate-binding site; other site 478433010148 HXXH motif; other site 478433010149 Rossmann-like domain; Region: Rossmann-like; pfam10727 478433010150 Uncharacterized conserved protein [Function unknown]; Region: COG5495 478433010151 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 478433010152 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 478433010153 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 478433010154 catalytic center binding site [active] 478433010155 ATP binding site [chemical binding]; other site 478433010156 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 478433010157 homooctamer interface [polypeptide binding]; other site 478433010158 active site 478433010159 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 478433010160 dihydropteroate synthase; Region: DHPS; TIGR01496 478433010161 substrate binding pocket [chemical binding]; other site 478433010162 dimer interface [polypeptide binding]; other site 478433010163 inhibitor binding site; inhibition site 478433010164 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 478433010165 homodecamer interface [polypeptide binding]; other site 478433010166 GTP cyclohydrolase I; Provisional; Region: PLN03044 478433010167 active site 478433010168 putative catalytic site residues [active] 478433010169 zinc binding site [ion binding]; other site 478433010170 GTP-CH-I/GFRP interaction surface; other site 478433010171 FtsH Extracellular; Region: FtsH_ext; pfam06480 478433010172 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 478433010173 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 478433010174 Walker A motif; other site 478433010175 ATP binding site [chemical binding]; other site 478433010176 Walker B motif; other site 478433010177 arginine finger; other site 478433010178 Peptidase family M41; Region: Peptidase_M41; pfam01434 478433010179 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 478433010180 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 478433010181 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 478433010182 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 478433010183 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 478433010184 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 478433010185 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 478433010186 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478433010187 PPE family; Region: PPE; pfam00823 478433010188 PE family; Region: PE; pfam00934 478433010189 Uncharacterized conserved protein [Function unknown]; Region: COG2968 478433010190 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 478433010191 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 478433010192 active site 478433010193 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 478433010194 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 478433010195 Ligand Binding Site [chemical binding]; other site 478433010196 Uncharacterized conserved protein [Function unknown]; Region: COG5282 478433010197 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 478433010198 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; pfam02113 478433010199 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 478433010200 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 478433010201 dimer interface [polypeptide binding]; other site 478433010202 substrate binding site [chemical binding]; other site 478433010203 metal binding sites [ion binding]; metal-binding site 478433010204 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2899 478433010205 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 478433010206 Ligand binding site; other site 478433010207 Putative Catalytic site; other site 478433010208 DXD motif; other site 478433010209 Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034 478433010210 Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5285 478433010211 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 478433010212 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 478433010213 NAD(P) binding site [chemical binding]; other site 478433010214 active site 478433010215 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 478433010216 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 478433010217 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 478433010218 transposase; Provisional; Region: PRK06526 478433010219 IstB-like ATP binding protein; Region: IstB_IS21; pfam01695 478433010220 Walker B motif; other site 478433010221 putative transposase OrfB; Reviewed; Region: PHA02517 478433010222 HTH-like domain; Region: HTH_21; pfam13276 478433010223 Integrase core domain; Region: rve; pfam00665 478433010224 Integrase core domain; Region: rve_3; pfam13683 478433010225 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 478433010226 Transposase; Region: HTH_Tnp_1; cl17663 478433010227 Transposase, Mutator family; Region: Transposase_mut; pfam00872 478433010228 MULE transposase domain; Region: MULE; pfam10551 478433010229 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 478433010230 Fic/DOC family; Region: Fic; cl00960 478433010231 VbhA antitoxin and related proteins; Region: VbhA_like; cd11586 478433010232 DNA polymerase III subunit delta'; Validated; Region: PRK07940 478433010233 DNA polymerase III subunit delta'; Validated; Region: PRK08485 478433010234 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 478433010235 dimerization interface [polypeptide binding]; other site 478433010236 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 478433010237 cyclase homology domain; Region: CHD; cd07302 478433010238 nucleotidyl binding site; other site 478433010239 metal binding site [ion binding]; metal-binding site 478433010240 dimer interface [polypeptide binding]; other site 478433010241 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 478433010242 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 478433010243 active site 478433010244 interdomain interaction site; other site 478433010245 putative metal-binding site [ion binding]; other site 478433010246 nucleotide binding site [chemical binding]; other site 478433010247 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 478433010248 domain I; other site 478433010249 phosphate binding site [ion binding]; other site 478433010250 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 478433010251 domain II; other site 478433010252 domain III; other site 478433010253 nucleotide binding site [chemical binding]; other site 478433010254 DNA binding groove [nucleotide binding] 478433010255 catalytic site [active] 478433010256 domain IV; other site 478433010257 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 478433010258 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 478433010259 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 478433010260 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 478433010261 DNA-binding site [nucleotide binding]; DNA binding site 478433010262 RNA-binding motif; other site 478433010263 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 478433010264 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 478433010265 ATP binding site [chemical binding]; other site 478433010266 putative Mg++ binding site [ion binding]; other site 478433010267 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 478433010268 nucleotide binding region [chemical binding]; other site 478433010269 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 478433010270 PE family; Region: PE; pfam00934 478433010271 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 478433010272 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 478433010273 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 478433010274 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 478433010275 Walker A motif; other site 478433010276 hexamer interface [polypeptide binding]; other site 478433010277 ATP binding site [chemical binding]; other site 478433010278 Walker B motif; other site 478433010279 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 478433010280 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 478433010281 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 478433010282 motif II; other site 478433010283 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 478433010284 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 478433010285 Walker A/P-loop; other site 478433010286 ATP binding site [chemical binding]; other site 478433010287 Q-loop/lid; other site 478433010288 ABC transporter signature motif; other site 478433010289 Walker B; other site 478433010290 D-loop; other site 478433010291 H-loop/switch region; other site 478433010292 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 478433010293 Walker A/P-loop; other site 478433010294 ATP binding site [chemical binding]; other site 478433010295 Q-loop/lid; other site 478433010296 ABC transporter signature motif; other site 478433010297 Walker B; other site 478433010298 D-loop; other site 478433010299 H-loop/switch region; other site 478433010300 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 478433010301 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 478433010302 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 478433010303 ABC-ATPase subunit interface; other site 478433010304 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 478433010305 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 478433010306 dimer interface [polypeptide binding]; other site 478433010307 conserved gate region; other site 478433010308 ABC-ATPase subunit interface; other site 478433010309 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 478433010310 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 478433010311 acetyl-CoA synthetase; Provisional; Region: PRK00174 478433010312 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 478433010313 active site 478433010314 CoA binding site [chemical binding]; other site 478433010315 acyl-activating enzyme (AAE) consensus motif; other site 478433010316 AMP binding site [chemical binding]; other site 478433010317 acetate binding site [chemical binding]; other site 478433010318 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 478433010319 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 478433010320 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 478433010321 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 478433010322 putative active site [active] 478433010323 putative CoA binding site [chemical binding]; other site 478433010324 nudix motif; other site 478433010325 metal binding site [ion binding]; metal-binding site 478433010326 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 478433010327 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 478433010328 catalytic residues [active] 478433010329 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 478433010330 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 478433010331 minor groove reading motif; other site 478433010332 helix-hairpin-helix signature motif; other site 478433010333 substrate binding pocket [chemical binding]; other site 478433010334 active site 478433010335 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 478433010336 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 478433010337 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 478433010338 ligand binding site [chemical binding]; other site 478433010339 flexible hinge region; other site 478433010340 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 478433010341 putative switch regulator; other site 478433010342 non-specific DNA interactions [nucleotide binding]; other site 478433010343 DNA binding site [nucleotide binding] 478433010344 sequence specific DNA binding site [nucleotide binding]; other site 478433010345 putative cAMP binding site [chemical binding]; other site 478433010346 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 478433010347 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 478433010348 homotrimer interaction site [polypeptide binding]; other site 478433010349 putative active site [active] 478433010350 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 478433010351 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 478433010352 P loop; other site 478433010353 Nucleotide binding site [chemical binding]; other site 478433010354 DTAP/Switch II; other site 478433010355 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 478433010356 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 478433010357 DTAP/Switch II; other site 478433010358 Switch I; other site 478433010359 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 478433010360 Transcription factor WhiB; Region: Whib; pfam02467 478433010361 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 478433010362 Transglycosylase; Region: Transgly; pfam00912 478433010363 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 478433010364 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 478433010365 phosphodiesterase YaeI; Provisional; Region: PRK11340 478433010366 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 478433010367 putative active site [active] 478433010368 putative metal binding site [ion binding]; other site 478433010369 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 478433010370 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 478433010371 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 478433010372 catalytic residue [active] 478433010373 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 478433010374 Cytochrome P450; Region: p450; cl12078 478433010375 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 478433010376 anti sigma factor interaction site; other site 478433010377 regulatory phosphorylation site [posttranslational modification]; other site 478433010378 Uncharacterized conserved protein [Function unknown]; Region: COG1610 478433010379 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 478433010380 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 478433010381 MoxR-like ATPases [General function prediction only]; Region: COG0714 478433010382 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 478433010383 Walker A motif; other site 478433010384 ATP binding site [chemical binding]; other site 478433010385 Walker B motif; other site 478433010386 arginine finger; other site 478433010387 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 478433010388 Protein of unknown function DUF58; Region: DUF58; pfam01882 478433010389 Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300 478433010390 Predicted membrane protein/domain [Function unknown]; Region: COG1714 478433010391 glycerol kinase; Provisional; Region: glpK; PRK00047 478433010392 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 478433010393 nucleotide binding site [chemical binding]; other site 478433010394 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 478433010395 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 478433010396 Methyltransferase domain; Region: Methyltransf_23; pfam13489 478433010397 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478433010398 S-adenosylmethionine binding site [chemical binding]; other site 478433010399 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 478433010400 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 478433010401 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 478433010402 catalytic residue [active] 478433010403 Uncharacterized conserved protein [Function unknown]; Region: COG4301 478433010404 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 478433010405 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 478433010406 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 478433010407 putative active site [active] 478433010408 putative dimer interface [polypeptide binding]; other site 478433010409 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 478433010410 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 478433010411 Gamma-glutamylcysteine synthetase [Coenzyme metabolism]; Region: GshA; COG3572 478433010412 PknH-like extracellular domain; Region: PknH_C; pfam14032 478433010413 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 478433010414 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 478433010415 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 478433010416 aspartate kinase; Reviewed; Region: PRK06635 478433010417 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 478433010418 putative nucleotide binding site [chemical binding]; other site 478433010419 putative catalytic residues [active] 478433010420 putative Mg ion binding site [ion binding]; other site 478433010421 putative aspartate binding site [chemical binding]; other site 478433010422 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 478433010423 putative allosteric regulatory site; other site 478433010424 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 478433010425 putative allosteric regulatory residue; other site 478433010426 2-isopropylmalate synthase; Validated; Region: PRK03739 478433010427 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 478433010428 active site 478433010429 catalytic residues [active] 478433010430 metal binding site [ion binding]; metal-binding site 478433010431 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 478433010432 DNA polymerase III subunit epsilon; Provisional; Region: PRK06063 478433010433 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 478433010434 active site 478433010435 catalytic site [active] 478433010436 substrate binding site [chemical binding]; other site 478433010437 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 478433010438 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 478433010439 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 478433010440 catalytic triad [active] 478433010441 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 478433010442 putative active site [active] 478433010443 recombination protein RecR; Reviewed; Region: recR; PRK00076 478433010444 RecR protein; Region: RecR; pfam02132 478433010445 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 478433010446 putative active site [active] 478433010447 putative metal-binding site [ion binding]; other site 478433010448 tetramer interface [polypeptide binding]; other site 478433010449 hypothetical protein; Validated; Region: PRK00153 478433010450 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 478433010451 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 478433010452 active site 478433010453 metal binding site [ion binding]; metal-binding site 478433010454 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 478433010455 hydrophobic ligand binding site; other site 478433010456 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 478433010457 FAD binding domain; Region: FAD_binding_4; pfam01565 478433010458 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 478433010459 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478433010460 S-adenosylmethionine binding site [chemical binding]; other site 478433010461 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14952 478433010462 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 478433010463 Walker A motif; other site 478433010464 ATP binding site [chemical binding]; other site 478433010465 Walker B motif; other site 478433010466 arginine finger; other site 478433010467 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 478433010468 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 478433010469 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 478433010470 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 478433010471 catalytic residue [active] 478433010472 Cutinase; Region: Cutinase; pfam01083 478433010473 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 478433010474 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 478433010475 NAD(P) binding site [chemical binding]; other site 478433010476 active site 478433010477 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 478433010478 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH8; cd08262 478433010479 putative NAD(P) binding site [chemical binding]; other site 478433010480 catalytic Zn binding site [ion binding]; other site 478433010481 Uncharacterized conserved protein [Function unknown]; Region: COG3349 478433010482 Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl17487 478433010483 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 478433010484 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 478433010485 putative substrate translocation pore; other site 478433010486 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 478433010487 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 478433010488 ligand binding site [chemical binding]; other site 478433010489 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 478433010490 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 478433010491 active site 478433010492 nucleophile elbow; other site 478433010493 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG1964 478433010494 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 478433010495 FeS/SAM binding site; other site 478433010496 Methyltransferase domain; Region: Methyltransf_31; pfam13847 478433010497 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478433010498 S-adenosylmethionine binding site [chemical binding]; other site 478433010499 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 478433010500 nucleotide binding site [chemical binding]; other site 478433010501 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 478433010502 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 478433010503 active site 478433010504 DNA binding site [nucleotide binding] 478433010505 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 478433010506 DNA binding site [nucleotide binding] 478433010507 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4402 478433010508 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_5; cd04662 478433010509 nudix motif; other site 478433010510 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 478433010511 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 478433010512 Uncharacterized conserved protein [Function unknown]; Region: COG1839 478433010513 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 478433010514 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 478433010515 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 478433010516 Uncharacterized conserved protein [Function unknown]; Region: COG2966 478433010517 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 478433010518 Uncharacterized conserved protein [Function unknown]; Region: COG3610 478433010519 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478433010520 PPE family; Region: PPE; pfam00823 478433010521 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478433010522 PPE family; Region: PPE; pfam00823 478433010523 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 478433010524 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 478433010525 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 478433010526 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 478433010527 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 478433010528 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 478433010529 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 478433010530 Soluble P-type ATPase [General function prediction only]; Region: COG4087 478433010531 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 478433010532 dimerization interface [polypeptide binding]; other site 478433010533 putative DNA binding site [nucleotide binding]; other site 478433010534 putative Zn2+ binding site [ion binding]; other site 478433010535 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3651 478433010536 DNA binding domain, excisionase family; Region: excise; TIGR01764 478433010537 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 478433010538 active site 478433010539 Int/Topo IB signature motif; other site 478433010540 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 478433010541 nucleoside/Zn binding site; other site 478433010542 dimer interface [polypeptide binding]; other site 478433010543 catalytic motif [active] 478433010544 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 478433010545 prephenate dehydrogenase; Validated; Region: PRK06545 478433010546 prephenate dehydrogenase; Validated; Region: PRK08507 478433010547 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3554 478433010548 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 478433010549 ABC-ATPase subunit interface; other site 478433010550 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 478433010551 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 478433010552 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 478433010553 Walker A/P-loop; other site 478433010554 ATP binding site [chemical binding]; other site 478433010555 Q-loop/lid; other site 478433010556 ABC transporter signature motif; other site 478433010557 Walker B; other site 478433010558 D-loop; other site 478433010559 H-loop/switch region; other site 478433010560 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 478433010561 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 478433010562 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 478433010563 putative active site [active] 478433010564 putative substrate binding site [chemical binding]; other site 478433010565 ATP binding site [chemical binding]; other site 478433010566 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 478433010567 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 478433010568 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 478433010569 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 478433010570 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 478433010571 dimerization interface [polypeptide binding]; other site 478433010572 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 478433010573 dimer interface [polypeptide binding]; other site 478433010574 phosphorylation site [posttranslational modification] 478433010575 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 478433010576 ATP binding site [chemical binding]; other site 478433010577 Mg2+ binding site [ion binding]; other site 478433010578 G-X-G motif; other site 478433010579 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 478433010580 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 478433010581 active site 478433010582 phosphorylation site [posttranslational modification] 478433010583 intermolecular recognition site; other site 478433010584 dimerization interface [polypeptide binding]; other site 478433010585 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 478433010586 DNA binding site [nucleotide binding] 478433010587 Photosystem II reaction centre W protein (PsbW); Region: PsbW; cl06243 478433010588 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 478433010589 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 478433010590 SnoaL-like domain; Region: SnoaL_2; pfam12680 478433010591 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 478433010592 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 478433010593 pyridoxal 5'-phosphate binding site [chemical binding]; other site 478433010594 homodimer interface [polypeptide binding]; other site 478433010595 catalytic residue [active] 478433010596 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 478433010597 TIGR03086 family protein; Region: TIGR03086 478433010598 enoyl-CoA hydratase; Provisional; Region: PRK06142 478433010599 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 478433010600 substrate binding site [chemical binding]; other site 478433010601 oxyanion hole (OAH) forming residues; other site 478433010602 trimer interface [polypeptide binding]; other site 478433010603 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 478433010604 Beta-lactamase; Region: Beta-lactamase; pfam00144 478433010605 Domain of unknown function (DUF222); Region: DUF222; pfam02720 478433010606 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 478433010607 active site 478433010608 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 478433010609 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 478433010610 NAD(P) binding site [chemical binding]; other site 478433010611 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 478433010612 cysteine desulfurase family protein, VC1184 subfamily; Region: am_tr_V_VC1184; TIGR01976 478433010613 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 478433010614 catalytic residue [active] 478433010615 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 478433010616 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 478433010617 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 478433010618 Walker A/P-loop; other site 478433010619 ATP binding site [chemical binding]; other site 478433010620 Q-loop/lid; other site 478433010621 ABC transporter signature motif; other site 478433010622 Walker B; other site 478433010623 D-loop; other site 478433010624 H-loop/switch region; other site 478433010625 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 478433010626 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 478433010627 active site 478433010628 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 478433010629 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 478433010630 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 478433010631 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 478433010632 NAD binding site [chemical binding]; other site 478433010633 substrate binding site [chemical binding]; other site 478433010634 active site 478433010635 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 478433010636 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 478433010637 active site 478433010638 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 478433010639 Peptidase family M23; Region: Peptidase_M23; pfam01551 478433010640 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 478433010641 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 478433010642 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05892 478433010643 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 478433010644 Predicted membrane protein [Function unknown]; Region: COG2246 478433010645 GtrA-like protein; Region: GtrA; pfam04138 478433010646 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 478433010647 FAD binding domain; Region: FAD_binding_4; pfam01565 478433010648 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 478433010649 short chain dehydrogenase; Provisional; Region: PRK07904 478433010650 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 478433010651 NAD(P) binding site [chemical binding]; other site 478433010652 active site 478433010653 Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250 478433010654 Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249 478433010655 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 478433010656 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 478433010657 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 478433010658 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 478433010659 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 478433010660 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 478433010661 FAD binding site [chemical binding]; other site 478433010662 substrate binding site [chemical binding]; other site 478433010663 catalytic residues [active] 478433010664 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 478433010665 Transposase; Region: DDE_Tnp_ISL3; pfam01610 478433010666 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 478433010667 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 478433010668 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 478433010669 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 478433010670 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 478433010671 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 478433010672 active site 478433010673 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 478433010674 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 478433010675 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 478433010676 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 478433010677 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 478433010678 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 478433010679 acyl-activating enzyme (AAE) consensus motif; other site 478433010680 active site 478433010681 Cutinase; Region: Cutinase; pfam01083 478433010682 Predicted esterase [General function prediction only]; Region: COG0627 478433010683 Putative esterase; Region: Esterase; pfam00756 478433010684 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 478433010685 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 478433010686 active site 478433010687 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 478433010688 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 478433010689 active site 478433010690 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 478433010691 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 478433010692 UDP-galactopyranose mutase; Region: GLF; pfam03275 478433010693 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 478433010694 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 478433010695 amidase catalytic site [active] 478433010696 Zn binding residues [ion binding]; other site 478433010697 substrate binding site [chemical binding]; other site 478433010698 LGFP repeat; Region: LGFP; pfam08310 478433010699 PE family; Region: PE; pfam00934 478433010700 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 478433010701 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 478433010702 active site 478433010703 motif I; other site 478433010704 motif II; other site 478433010705 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 478433010706 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 478433010707 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 478433010708 putative acyl-acceptor binding pocket; other site 478433010709 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 478433010710 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 478433010711 putative acyl-acceptor binding pocket; other site 478433010712 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 478433010713 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 478433010714 putative acyl-acceptor binding pocket; other site 478433010715 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 478433010716 Phosphotransferase enzyme family; Region: APH; pfam01636 478433010717 active site 478433010718 ATP binding site [chemical binding]; other site 478433010719 antibiotic binding site [chemical binding]; other site 478433010720 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 478433010721 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 478433010722 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 478433010723 iron-sulfur cluster [ion binding]; other site 478433010724 [2Fe-2S] cluster binding site [ion binding]; other site 478433010725 Condensation domain; Region: Condensation; pfam00668 478433010726 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 478433010727 PE-PPE domain; Region: PE-PPE; pfam08237 478433010728 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 478433010729 Condensation domain; Region: Condensation; pfam00668 478433010730 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 478433010731 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 478433010732 active site 478433010733 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 478433010734 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 478433010735 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 478433010736 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 478433010737 Enoylreductase; Region: PKS_ER; smart00829 478433010738 NAD(P) binding site [chemical binding]; other site 478433010739 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 478433010740 KR domain; Region: KR; pfam08659 478433010741 putative NADP binding site [chemical binding]; other site 478433010742 active site 478433010743 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 478433010744 acyl-CoA synthetase; Validated; Region: PRK05850 478433010745 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 478433010746 acyl-activating enzyme (AAE) consensus motif; other site 478433010747 active site 478433010748 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 478433010749 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 478433010750 Probable transposase; Region: OrfB_IS605; pfam01385 478433010751 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 478433010752 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 478433010753 catalytic residues [active] 478433010754 catalytic nucleophile [active] 478433010755 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 478433010756 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 478433010757 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 478433010758 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478433010759 Protein of unknown function (DUF2834); Region: DUF2834; pfam11196 478433010760 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478433010761 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 478433010762 Cupin domain; Region: Cupin_2; cl17218 478433010763 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 478433010764 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 478433010765 seryl-tRNA synthetase; Provisional; Region: PRK05431 478433010766 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 478433010767 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 478433010768 dimer interface [polypeptide binding]; other site 478433010769 active site 478433010770 motif 1; other site 478433010771 motif 2; other site 478433010772 motif 3; other site 478433010773 Septum formation; Region: Septum_form; pfam13845 478433010774 Septum formation; Region: Septum_form; pfam13845 478433010775 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 478433010776 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 478433010777 catalytic core [active] 478433010778 prephenate dehydratase; Provisional; Region: PRK11898 478433010779 Prephenate dehydratase; Region: PDT; pfam00800 478433010780 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 478433010781 putative L-Phe binding site [chemical binding]; other site 478433010782 Transcriptional regulator [Transcription]; Region: LytR; COG1316 478433010783 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 478433010784 Ferritin-like domain; Region: Ferritin; pfam00210 478433010785 ferroxidase diiron center [ion binding]; other site 478433010786 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582 478433010787 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 478433010788 putative active site [active] 478433010789 catalytic site [active] 478433010790 putative metal binding site [ion binding]; other site 478433010791 Domain of unknown function (DUF4328); Region: DUF4328; pfam14219 478433010792 Transposase; Region: DEDD_Tnp_IS110; pfam01548 478433010793 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 478433010794 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 478433010795 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 478433010796 Predicted membrane protein [Function unknown]; Region: COG2119 478433010797 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 478433010798 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 478433010799 Fimbrial protein; Region: Fimbrial; cl01416 478433010800 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 478433010801 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 478433010802 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 478433010803 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 478433010804 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478433010805 hypothetical protein; Provisional; Region: PRK07945 478433010806 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 478433010807 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 478433010808 active site 478433010809 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 478433010810 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 478433010811 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 478433010812 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 478433010813 active site 478433010814 dimer interface [polypeptide binding]; other site 478433010815 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 478433010816 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 478433010817 active site 478433010818 FMN binding site [chemical binding]; other site 478433010819 substrate binding site [chemical binding]; other site 478433010820 3Fe-4S cluster binding site [ion binding]; other site 478433010821 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 478433010822 domain interface; other site 478433010823 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 478433010824 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 478433010825 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 478433010826 EspG family; Region: ESX-1_EspG; pfam14011 478433010827 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 478433010828 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 478433010829 Walker A motif; other site 478433010830 ATP binding site [chemical binding]; other site 478433010831 Walker B motif; other site 478433010832 arginine finger; other site 478433010833 Protein of unknown function (DUF690); Region: DUF690; pfam05108 478433010834 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 478433010835 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 478433010836 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 478433010837 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 478433010838 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 478433010839 PE family; Region: PE; pfam00934 478433010840 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 478433010841 PPE family; Region: PPE; pfam00823 478433010842 Proteins of 100 residues with WXG; Region: WXG100; cl02005 478433010843 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 478433010844 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 478433010845 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 478433010846 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 478433010847 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 478433010848 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 478433010849 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 478433010850 active site 478433010851 catalytic residues [active] 478433010852 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 478433010853 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 478433010854 Walker A motif; other site 478433010855 ATP binding site [chemical binding]; other site 478433010856 Walker B motif; other site 478433010857 arginine finger; other site 478433010858 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 478433010859 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 478433010860 catalytic residues [active] 478433010861 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 478433010862 active site 478433010863 catalytic residues [active] 478433010864 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 478433010865 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 478433010866 EspG family; Region: ESX-1_EspG; pfam14011 478433010867 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 478433010868 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 478433010869 PPE family; Region: PPE; pfam00823 478433010870 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 478433010871 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 478433010872 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 478433010873 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 478433010874 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 478433010875 Protein of unknown function (DUF690); Region: DUF690; pfam05108 478433010876 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 478433010877 N-acetyl-D-glucosamine binding site [chemical binding]; other site 478433010878 catalytic residue [active] 478433010879 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 478433010880 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 478433010881 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 478433010882 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 478433010883 active site 478433010884 NTP binding site [chemical binding]; other site 478433010885 metal binding triad [ion binding]; metal-binding site 478433010886 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 478433010887 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 478433010888 Zn2+ binding site [ion binding]; other site 478433010889 Mg2+ binding site [ion binding]; other site 478433010890 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 478433010891 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 478433010892 active site 478433010893 Ap6A binding site [chemical binding]; other site 478433010894 nudix motif; other site 478433010895 metal binding site [ion binding]; metal-binding site 478433010896 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 478433010897 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 478433010898 RNA polymerase sigma factor SigM; Reviewed; Region: PRK09643 478433010899 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 478433010900 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 478433010901 DNA binding residues [nucleotide binding] 478433010902 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 478433010903 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 478433010904 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 478433010905 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 478433010906 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 478433010907 catalytic residues [active] 478433010908 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 478433010909 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 478433010910 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 478433010911 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 478433010912 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 478433010913 active site 478433010914 metal binding site [ion binding]; metal-binding site 478433010915 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 478433010916 ParB-like nuclease domain; Region: ParB; smart00470 478433010917 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 478433010918 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 478433010919 P-loop; other site 478433010920 Magnesium ion binding site [ion binding]; other site 478433010921 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 478433010922 Magnesium ion binding site [ion binding]; other site 478433010923 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 478433010924 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 478433010925 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 478433010926 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 478433010927 G-X-X-G motif; other site 478433010928 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 478433010929 RxxxH motif; other site 478433010930 putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449 478433010931 Uncharacterized conserved protein [Function unknown]; Region: COG0759 478433010932 ribonuclease P; Reviewed; Region: rnpA; PRK00588 478433010933 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399