-- dump date 20140619_155120 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1091500000001 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 1091500000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1091500000003 Walker A motif; other site 1091500000004 ATP binding site [chemical binding]; other site 1091500000005 Walker B motif; other site 1091500000006 arginine finger; other site 1091500000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1091500000008 DnaA box-binding interface [nucleotide binding]; other site 1091500000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 1091500000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1091500000011 putative DNA binding surface [nucleotide binding]; other site 1091500000012 dimer interface [polypeptide binding]; other site 1091500000013 beta-clamp/clamp loader binding surface; other site 1091500000014 beta-clamp/translesion DNA polymerase binding surface; other site 1091500000015 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1091500000016 Q-loop/lid; other site 1091500000017 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1091500000018 Walker B; other site 1091500000019 D-loop; other site 1091500000020 H-loop/switch region; other site 1091500000021 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1091500000022 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1091500000023 Mg2+ binding site [ion binding]; other site 1091500000024 G-X-G motif; other site 1091500000025 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1091500000026 anchoring element; other site 1091500000027 dimer interface [polypeptide binding]; other site 1091500000028 ATP binding site [chemical binding]; other site 1091500000029 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1091500000030 active site 1091500000031 putative metal-binding site [ion binding]; other site 1091500000032 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1091500000033 DNA gyrase subunit A; Validated; Region: PRK05560 1091500000034 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1091500000035 CAP-like domain; other site 1091500000036 active site 1091500000037 primary dimer interface [polypeptide binding]; other site 1091500000038 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1091500000039 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1091500000040 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1091500000041 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1091500000042 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1091500000043 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1091500000044 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 1091500000045 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 1091500000046 Protein of unknown function (DUF2562); Region: DUF2562; pfam10814 1091500000047 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1091500000048 active site 1091500000049 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1091500000050 Uncharacterized protein family (UPF0233); Region: UPF0233; cl11506 1091500000051 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 1091500000052 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1091500000053 potential frameshift: common BLAST hit: gi|375294214|ref|YP_005098481.1| anthranilate synthase component II trpG 1091500000054 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1091500000055 conserved cys residue [active] 1091500000056 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1091500000057 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1091500000058 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1091500000059 active site 1091500000060 ATP binding site [chemical binding]; other site 1091500000061 substrate binding site [chemical binding]; other site 1091500000062 activation loop (A-loop); other site 1091500000063 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 1091500000064 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1091500000065 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1091500000066 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1091500000067 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1091500000068 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1091500000069 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1091500000070 active site 1091500000071 ATP binding site [chemical binding]; other site 1091500000072 substrate binding site [chemical binding]; other site 1091500000073 activation loop (A-loop); other site 1091500000074 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1091500000075 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1091500000076 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1091500000077 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1091500000078 active site 1091500000079 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1091500000080 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1091500000081 phosphopeptide binding site; other site 1091500000082 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1091500000083 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1091500000084 phosphopeptide binding site; other site 1091500000085 potential frameshift: common BLAST hit: gi|148659780|ref|YP_001281303.1| 2-nitropropane dioxygenase 1091500000086 Transcription factor WhiB; Region: Whib; pfam02467 1091500000087 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1091500000088 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1091500000089 non-specific DNA binding site [nucleotide binding]; other site 1091500000090 salt bridge; other site 1091500000091 sequence-specific DNA binding site [nucleotide binding]; other site 1091500000092 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1091500000093 NlpC/P60 family; Region: NLPC_P60; pfam00877 1091500000094 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 1091500000095 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 1091500000096 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 1091500000097 Protein of unknown function (DUF2694); Region: DUF2694; pfam10904 1091500000098 Protein of unknown function (DUF2710); Region: DUF2710; pfam10921 1091500000099 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1091500000100 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 1091500000101 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1091500000102 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1091500000103 catalytic residue [active] 1091500000104 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 1091500000105 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 1091500000106 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1091500000107 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1091500000108 acyl-activating enzyme (AAE) consensus motif; other site 1091500000109 active site 1091500000110 TIGR03084 family protein; Region: TIGR03084 1091500000111 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1091500000112 Wyosine base formation; Region: Wyosine_form; pfam08608 1091500000113 H+ Antiporter protein; Region: 2A0121; TIGR00900 1091500000114 hypothetical protein; Validated; Region: PRK00228 1091500000115 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 1091500000116 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1091500000117 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1091500000118 active site 1091500000119 HIGH motif; other site 1091500000120 nucleotide binding site [chemical binding]; other site 1091500000121 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1091500000122 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1091500000123 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1091500000124 active site 1091500000125 KMSKS motif; other site 1091500000126 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1091500000127 tRNA binding surface [nucleotide binding]; other site 1091500000128 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1091500000129 MarR family; Region: MarR; pfam01047 1091500000130 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1091500000131 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1091500000132 DNA-binding site [nucleotide binding]; DNA binding site 1091500000133 potential frameshift: common BLAST hit: gi|340625077|ref|YP_004743529.1| putative oxidoreductase 1091500000134 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1091500000135 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 1091500000136 inositol 1-phosphate synthase, Actinobacterial type; Region: mycothiol_INO1; TIGR03450 1091500000137 Predicted transcriptional regulators [Transcription]; Region: COG1695 1091500000138 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1091500000139 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1091500000140 Transglycosylase; Region: Transgly; pfam00912 1091500000141 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1091500000142 potential frameshift: common BLAST hit: gi|224988434|ref|YP_002643101.1| transmembrane protein 1091500000143 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 1091500000144 potential frameshift: common BLAST hit: gi|340625086|ref|YP_004743538.1| putative 30S ribosomal protein S6 RPSF 1091500000145 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1091500000146 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1091500000147 ssDNA binding site [nucleotide binding]; other site 1091500000148 dimer interface [polypeptide binding]; other site 1091500000149 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1091500000150 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1091500000151 potential frameshift: common BLAST hit: gi|340625089|ref|YP_004743541.1| putative 50S ribosomal protein L9 RPLI 1091500000152 replicative DNA helicase; Validated; Region: PRK07773 1091500000153 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1091500000154 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1091500000155 Walker A motif; other site 1091500000156 ATP binding site [chemical binding]; other site 1091500000157 Walker B motif; other site 1091500000158 DNA binding loops [nucleotide binding] 1091500000159 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1091500000160 protein-splicing catalytic site; other site 1091500000161 thioester formation/cholesterol transfer; other site 1091500000162 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1091500000163 protein-splicing catalytic site; other site 1091500000164 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1091500000165 Cellobiohydrolase A (1,4-beta-cellobiosidase A) [Carbohydrate transport and metabolism]; Region: CelA; COG5297 1091500000166 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 1091500000167 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1091500000168 FAD binding domain; Region: FAD_binding_4; pfam01565 1091500000169 Berberine and berberine like; Region: BBE; pfam08031 1091500000170 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 1091500000171 homotetrameric interface [polypeptide binding]; other site 1091500000172 putative active site [active] 1091500000173 metal binding site [ion binding]; metal-binding site 1091500000174 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 1091500000175 Monomeric isocitrate dehydrogenase; Region: IDH; pfam03971 1091500000176 potential frameshift: common BLAST hit: gi|339630150|ref|YP_004721792.1| TetR family transcriptional regulator 1091500000177 potential frameshift: common BLAST hit: gi|340625102|ref|YP_004743554.1| putative oxidoreductase 1091500000178 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1091500000179 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1091500000180 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1091500000181 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1091500000182 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1091500000183 dimer interface [polypeptide binding]; other site 1091500000184 active site 1091500000185 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1091500000186 folate binding site [chemical binding]; other site 1091500000187 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 1091500000188 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1091500000189 putative NTP binding site [chemical binding]; other site 1091500000190 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1091500000191 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1091500000192 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1091500000193 Walker A/P-loop; other site 1091500000194 ATP binding site [chemical binding]; other site 1091500000195 Q-loop/lid; other site 1091500000196 ABC transporter signature motif; other site 1091500000197 Walker B; other site 1091500000198 D-loop; other site 1091500000199 H-loop/switch region; other site 1091500000200 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1091500000201 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1091500000202 ligand binding site [chemical binding]; other site 1091500000203 flexible hinge region; other site 1091500000204 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 1091500000205 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1091500000206 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 1091500000207 active site 1091500000208 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1091500000209 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1091500000210 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1091500000211 homodimer interface [polypeptide binding]; other site 1091500000212 catalytic residue [active] 1091500000213 potential frameshift: common BLAST hit: gi|339630160|ref|YP_004721802.1| oxidoreductase 1091500000214 potential frameshift: common BLAST hit: gi|340625112|ref|YP_004743564.1| putative transcriptional regulatory protein 1091500000215 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 1091500000216 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1091500000217 dimerization interface [polypeptide binding]; other site 1091500000218 putative DNA binding site [nucleotide binding]; other site 1091500000219 putative Zn2+ binding site [ion binding]; other site 1091500000220 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 1091500000221 hydrogenase 4 subunit B; Validated; Region: PRK06521 1091500000222 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1091500000223 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1091500000224 NADH dehydrogenase; Region: NADHdh; cl00469 1091500000225 Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; COG4237 1091500000226 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1091500000227 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 1091500000228 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 1091500000229 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 1091500000230 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 1091500000231 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825 1091500000232 putative hydrophobic ligand binding site [chemical binding]; other site 1091500000233 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091500000234 S-adenosylmethionine binding site [chemical binding]; other site 1091500000235 Predicted membrane protein [Function unknown]; Region: COG3305 1091500000236 potential frameshift: common BLAST hit: gi|339630175|ref|YP_004721817.1| nucleosidase 1091500000237 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1091500000238 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1091500000239 metal-binding site [ion binding] 1091500000240 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1091500000241 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1091500000242 Predicted integral membrane protein [Function unknown]; Region: COG5660 1091500000243 Putative zinc-finger; Region: zf-HC2; pfam13490 1091500000244 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1091500000245 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1091500000246 active site 1091500000247 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1091500000248 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1091500000249 PPE family; Region: PPE; pfam00823 1091500000250 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1091500000251 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 1091500000252 FcoT-like thioesterase domain; Region: FcoT; pfam10862 1091500000253 potential frameshift: common BLAST hit: gi|339630183|ref|YP_004721825.1| fatty-acid-CoA ligase 1091500000254 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1091500000255 AMP-binding enzyme; Region: AMP-binding; pfam00501 1091500000256 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1091500000257 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1091500000258 acyl-activating enzyme (AAE) consensus motif; other site 1091500000259 acyl-activating enzyme (AAE) consensus motif; other site 1091500000260 active site 1091500000261 AMP binding site [chemical binding]; other site 1091500000262 CoA binding site [chemical binding]; other site 1091500000263 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1091500000264 Condensation domain; Region: Condensation; pfam00668 1091500000265 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1091500000266 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1091500000267 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1091500000268 acyl-activating enzyme (AAE) consensus motif; other site 1091500000269 AMP binding site [chemical binding]; other site 1091500000270 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1091500000271 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1091500000272 NAD(P) binding site [chemical binding]; other site 1091500000273 active site 1091500000274 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1091500000275 potential frameshift: common BLAST hit: gi|224988488|ref|YP_002643175.1| integral membrane protein 1091500000276 potential frameshift: common BLAST hit: gi|224988489|ref|YP_002643176.1| cation-transporter P-type ATPase B 1091500000277 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1091500000278 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1091500000279 ligand binding site [chemical binding]; other site 1091500000280 flexible hinge region; other site 1091500000281 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1091500000282 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1091500000283 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1091500000284 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1091500000285 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1091500000286 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1091500000287 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1091500000288 motif II; other site 1091500000289 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1091500000290 potential frameshift: common BLAST hit: gi|340625145|ref|YP_004743597.1| putative integral membrane protein 1091500000291 potential frameshift: common BLAST hit: gi|340625146|ref|YP_004743598.1| putative transmembrane acyltransferase 1091500000292 potential frameshift: common BLAST hit: gi|339630196|ref|YP_004721838.1| GDP-mannose 4,6-dehydratase 1091500000293 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1091500000294 dimer interface [polypeptide binding]; other site 1091500000295 active site 1091500000296 histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656 1091500000297 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1091500000298 active site 1091500000299 motif I; other site 1091500000300 motif II; other site 1091500000301 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 1091500000302 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1091500000303 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1091500000304 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1091500000305 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1091500000306 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1091500000307 dimerization interface [polypeptide binding]; other site 1091500000308 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 1091500000309 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1091500000310 PYR/PP interface [polypeptide binding]; other site 1091500000311 dimer interface [polypeptide binding]; other site 1091500000312 TPP binding site [chemical binding]; other site 1091500000313 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1091500000314 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 1091500000315 TPP-binding site; other site 1091500000316 dimer interface [polypeptide binding]; other site 1091500000317 acyl-CoA synthetase; Validated; Region: PRK05852 1091500000318 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1091500000319 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1091500000320 acyl-activating enzyme (AAE) consensus motif; other site 1091500000321 acyl-activating enzyme (AAE) consensus motif; other site 1091500000322 active site 1091500000323 AMP binding site [chemical binding]; other site 1091500000324 CoA binding site [chemical binding]; other site 1091500000325 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 1091500000326 elongation factor G; Reviewed; Region: PRK12740 1091500000327 G1 box; other site 1091500000328 putative GEF interaction site [polypeptide binding]; other site 1091500000329 GTP/Mg2+ binding site [chemical binding]; other site 1091500000330 Switch I region; other site 1091500000331 G2 box; other site 1091500000332 G3 box; other site 1091500000333 Switch II region; other site 1091500000334 G4 box; other site 1091500000335 G5 box; other site 1091500000336 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1091500000337 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1091500000338 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1091500000339 PPOX class probable F420-dependent enzyme, Rv0121 family; Region: Rv0121_F420; TIGR03668 1091500000340 PE family; Region: PE; pfam00934 1091500000341 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1091500000342 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1091500000343 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1091500000344 trehalose synthase; Region: treS_nterm; TIGR02456 1091500000345 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 1091500000346 active site 1091500000347 catalytic site [active] 1091500000348 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 1091500000349 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 1091500000350 Predicted membrane protein [Function unknown]; Region: COG3619 1091500000351 Predicted esterase [General function prediction only]; Region: COG0627 1091500000352 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 1091500000353 putative active site [active] 1091500000354 putative catalytic site [active] 1091500000355 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1091500000356 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1091500000357 active site 1091500000358 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 1091500000359 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1091500000360 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1091500000361 Coenzyme A binding pocket [chemical binding]; other site 1091500000362 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1091500000363 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1091500000364 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1091500000365 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1091500000366 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1091500000367 Cytochrome P450; Region: p450; cl12078 1091500000368 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1091500000369 SnoaL-like domain; Region: SnoaL_2; pfam12680 1091500000370 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1091500000371 NAD(P) binding site [chemical binding]; other site 1091500000372 active site 1091500000373 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 1091500000374 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 1091500000375 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 1091500000376 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1091500000377 minor groove reading motif; other site 1091500000378 helix-hairpin-helix signature motif; other site 1091500000379 active site 1091500000380 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1091500000381 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 1091500000382 Cl- selectivity filter; other site 1091500000383 Cl- binding residues [ion binding]; other site 1091500000384 pore gating glutamate residue; other site 1091500000385 dimer interface [polypeptide binding]; other site 1091500000386 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1091500000387 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1091500000388 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 1091500000389 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1091500000390 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1091500000391 glycine betaine aldehyde dehydrogenase; Region: BADH; TIGR01804 1091500000392 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1091500000393 NAD(P) binding site [chemical binding]; other site 1091500000394 catalytic residues [active] 1091500000395 short chain dehydrogenase; Provisional; Region: PRK07791 1091500000396 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 1091500000397 NAD binding site [chemical binding]; other site 1091500000398 homodimer interface [polypeptide binding]; other site 1091500000399 active site 1091500000400 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1091500000401 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 1091500000402 NAD(P) binding site [chemical binding]; other site 1091500000403 PE family; Region: PE; pfam00934 1091500000404 PE-PPE domain; Region: PE-PPE; pfam08237 1091500000405 PE-PPE domain; Region: PE-PPE; pfam08237 1091500000406 PE family; Region: PE; pfam00934 1091500000407 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 1091500000408 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 1091500000409 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 1091500000410 Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155 1091500000411 FAD binding site [chemical binding]; other site 1091500000412 substrate binding site [chemical binding]; other site 1091500000413 catalytic base [active] 1091500000414 Protein of unknown function (DUF1348); Region: DUF1348; pfam07080 1091500000415 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 1091500000416 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 1091500000417 ligand binding site [chemical binding]; other site 1091500000418 homodimer interface [polypeptide binding]; other site 1091500000419 NAD(P) binding site [chemical binding]; other site 1091500000420 trimer interface B [polypeptide binding]; other site 1091500000421 trimer interface A [polypeptide binding]; other site 1091500000422 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 1091500000423 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 1091500000424 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 1091500000425 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 1091500000426 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1091500000427 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1091500000428 QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360 1091500000429 PE family; Region: PE; pfam00934 1091500000430 PE-PPE domain; Region: PE-PPE; pfam08237 1091500000431 PE-PPE domain; Region: PE-PPE; pfam08237 1091500000432 PE family; Region: PE; pfam00934 1091500000433 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1091500000434 FAD binding domain; Region: FAD_binding_4; pfam01565 1091500000435 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 1091500000436 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1091500000437 NAD(P) binding site [chemical binding]; other site 1091500000438 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1091500000439 active site 1091500000440 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1091500000441 putative hydrophobic ligand binding site [chemical binding]; other site 1091500000442 potential frameshift: common BLAST hit: gi|224988550|ref|YP_002643237.1| transcriptional regulatory protein 1091500000443 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1091500000444 AMP-binding enzyme; Region: AMP-binding; pfam00501 1091500000445 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1091500000446 acyl-activating enzyme (AAE) consensus motif; other site 1091500000447 acyl-activating enzyme (AAE) consensus motif; other site 1091500000448 putative AMP binding site [chemical binding]; other site 1091500000449 putative active site [active] 1091500000450 putative CoA binding site [chemical binding]; other site 1091500000451 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1091500000452 Permease; Region: Permease; pfam02405 1091500000453 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1091500000454 Permease; Region: Permease; pfam02405 1091500000455 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1091500000456 mce related protein; Region: MCE; pfam02470 1091500000457 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1091500000458 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1091500000459 mce related protein; Region: MCE; pfam02470 1091500000460 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1091500000461 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1091500000462 mce related protein; Region: MCE; pfam02470 1091500000463 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1091500000464 mce related protein; Region: MCE; pfam02470 1091500000465 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1091500000466 mce related protein; Region: MCE; pfam02470 1091500000467 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1091500000468 mce related protein; Region: MCE; pfam02470 1091500000469 potential frameshift: common BLAST hit: gi|148821368|ref|YP_001286122.1| MCE associated membrane protein 1091500000470 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 1091500000471 Predicted membrane protein [Function unknown]; Region: COG1511 1091500000472 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1091500000473 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1091500000474 potential frameshift: common BLAST hit: gi|339630263|ref|YP_004721905.1| RNA polymerase sigma factor 1091500000475 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1091500000476 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1091500000477 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 1091500000478 putative metallohydrolase, TIGR04338 family; Region: HEXXH_Rv0185 1091500000479 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1091500000480 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1091500000481 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1091500000482 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1091500000483 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1091500000484 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091500000485 S-adenosylmethionine binding site [chemical binding]; other site 1091500000486 SPW repeat; Region: SPW; pfam03779 1091500000487 SPW repeat; Region: SPW; pfam03779 1091500000488 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 1091500000489 6-phosphogluconate dehydratase; Region: edd; TIGR01196 1091500000490 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 1091500000491 putative homodimer interface [polypeptide binding]; other site 1091500000492 putative homotetramer interface [polypeptide binding]; other site 1091500000493 putative allosteric switch controlling residues; other site 1091500000494 putative metal binding site [ion binding]; other site 1091500000495 putative homodimer-homodimer interface [polypeptide binding]; other site 1091500000496 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1091500000497 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1091500000498 putative substrate translocation pore; other site 1091500000499 potential frameshift: common BLAST hit: gi|253797116|ref|YP_003030117.1| drugs-transport transmembrane ATP-binding protein ABC transporter 1091500000500 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1091500000501 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1091500000502 dimerization interface [polypeptide binding]; other site 1091500000503 DNA binding residues [nucleotide binding] 1091500000504 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1091500000505 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1091500000506 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1091500000507 The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762 1091500000508 putative [Fe4-S4] binding site [ion binding]; other site 1091500000509 putative molybdopterin cofactor binding site [chemical binding]; other site 1091500000510 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1091500000511 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 1091500000512 putative molybdopterin cofactor binding site; other site 1091500000513 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 1091500000514 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 1091500000515 active site 1091500000516 Zn binding site [ion binding]; other site 1091500000517 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1091500000518 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 1091500000519 Predicted integral membrane protein [Function unknown]; Region: COG0392 1091500000520 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1091500000521 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1091500000522 MMPL family; Region: MMPL; pfam03176 1091500000523 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 1091500000524 MMPL family; Region: MMPL; pfam03176 1091500000525 Putative methyltransferase; Region: Methyltransf_4; pfam02390 1091500000526 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 1091500000527 active site 1091500000528 substrate-binding site [chemical binding]; other site 1091500000529 metal-binding site [ion binding] 1091500000530 GTP binding site [chemical binding]; other site 1091500000531 nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526 1091500000532 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 1091500000533 active site 1091500000534 (T/H)XGH motif; other site 1091500000535 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 1091500000536 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 1091500000537 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 1091500000538 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1091500000539 FeS/SAM binding site; other site 1091500000540 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1091500000541 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1091500000542 acyl-activating enzyme (AAE) consensus motif; other site 1091500000543 active site 1091500000544 AMP binding site [chemical binding]; other site 1091500000545 acyl-activating enzyme (AAE) consensus motif; other site 1091500000546 CoA binding site [chemical binding]; other site 1091500000547 potential frameshift: common BLAST hit: gi|253797137|ref|YP_003030138.1| acyl-CoA dehydrogenase 1091500000548 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 1091500000549 putative active site [active] 1091500000550 putative catalytic site [active] 1091500000551 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1091500000552 active site 2 [active] 1091500000553 active site 1 [active] 1091500000554 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1091500000555 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1091500000556 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1091500000557 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cd00321 1091500000558 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1091500000559 Moco binding site; other site 1091500000560 metal coordination site [ion binding]; other site 1091500000561 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1091500000562 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1091500000563 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1091500000564 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1091500000565 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 1091500000566 enoyl-CoA hydratase; Provisional; Region: PRK08252 1091500000567 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1091500000568 substrate binding site [chemical binding]; other site 1091500000569 oxyanion hole (OAH) forming residues; other site 1091500000570 trimer interface [polypeptide binding]; other site 1091500000571 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 1091500000572 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1091500000573 NAD binding site [chemical binding]; other site 1091500000574 catalytic residues [active] 1091500000575 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091500000576 S-adenosylmethionine binding site [chemical binding]; other site 1091500000577 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1091500000578 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 1091500000579 putative active site [active] 1091500000580 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 1091500000581 active site 1091500000582 substrate binding pocket [chemical binding]; other site 1091500000583 homodimer interaction site [polypeptide binding]; other site 1091500000584 potential frameshift: common BLAST hit: gi|339630307|ref|YP_004721949.1| acyl-CoA dehydrogenase 1091500000585 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1091500000586 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1091500000587 Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain; Region: RNRR2_Rv0233_like; cd07911 1091500000588 active site 1091500000589 diiron metal binding site [ion binding]; other site 1091500000590 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1091500000591 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1091500000592 NAD(P) binding site [chemical binding]; other site 1091500000593 catalytic residues [active] 1091500000594 Lipase maturation factor; Region: LMF1; pfam06762 1091500000595 potential frameshift: common BLAST hit: gi|224988621|ref|YP_002643308.1| transmembrane protein 1091500000596 potential frameshift: common BLAST hit: gi|148660000|ref|YP_001281523.1| transmembrane protein 1091500000597 Protein of unknown function (DUF2613); Region: DUF2613; pfam11021 1091500000598 potential frameshift: common BLAST hit: gi|148660002|ref|YP_001281525.1| lipoprotein LpqI 1091500000599 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1091500000600 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1091500000601 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 1091500000602 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1091500000603 MaoC like domain; Region: MaoC_dehydratas; pfam01575 1091500000604 active site 2 [active] 1091500000605 active site 1 [active] 1091500000606 potential frameshift: common BLAST hit: gi|339630319|ref|YP_004721961.1| 3-oxoacyl-ACP reductase 1091500000607 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 1091500000608 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1091500000609 dimer interface [polypeptide binding]; other site 1091500000610 active site 1091500000611 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1091500000612 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1091500000613 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 1091500000614 FAD binding site [chemical binding]; other site 1091500000615 substrate binding site [chemical binding]; other site 1091500000616 catalytic residues [active] 1091500000617 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1091500000618 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1091500000619 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386 1091500000620 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1091500000621 catalytic loop [active] 1091500000622 iron binding site [ion binding]; other site 1091500000623 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803 1091500000624 L-aspartate oxidase; Provisional; Region: PRK06175 1091500000625 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1091500000626 potential frameshift: common BLAST hit: gi|253797175|ref|YP_003030176.1| heat shock protein hsp 1091500000627 potential frameshift: common BLAST hit: gi|15839633|ref|NP_334670.1| NAD(P)H-dependent nitrite reductase, large subunit 1091500000628 potential frameshift: common BLAST hit: gi|339630329|ref|YP_004721971.1| nitrite reductase [NAD(P)H] large subunit 1091500000629 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 1091500000630 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 1091500000631 homotrimer interface [polypeptide binding]; other site 1091500000632 Walker A motif; other site 1091500000633 GTP binding site [chemical binding]; other site 1091500000634 Walker B motif; other site 1091500000635 cobyric acid synthase; Provisional; Region: PRK00784 1091500000636 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 1091500000637 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1091500000638 catalytic triad [active] 1091500000639 potential frameshift: common BLAST hit: gi|339630333|ref|YP_004721975.1| PPE family protein 1091500000640 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1091500000641 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1091500000642 putative active site [active] 1091500000643 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 1091500000644 putative active site [active] 1091500000645 potential frameshift: common BLAST hit: gi|339630336|ref|YP_004721978.1| transcriptional regulator 1091500000646 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1091500000647 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1091500000648 Coenzyme A binding pocket [chemical binding]; other site 1091500000649 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 1091500000650 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 1091500000651 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 1091500000652 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1091500000653 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1091500000654 intersubunit interface [polypeptide binding]; other site 1091500000655 potential frameshift: common BLAST hit: gi|339630342|ref|YP_004721984.1| 5-oxoprolinase 1091500000656 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1091500000657 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 1091500000658 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 1091500000659 nucleotide binding site [chemical binding]; other site 1091500000660 acyl-CoA synthetase; Validated; Region: PRK07788 1091500000661 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1091500000662 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1091500000663 active site 1091500000664 CoA binding site [chemical binding]; other site 1091500000665 AMP binding site [chemical binding]; other site 1091500000666 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1091500000667 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1091500000668 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 1091500000669 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1091500000670 FAD binding site [chemical binding]; other site 1091500000671 substrate binding site [chemical binding]; other site 1091500000672 catalytic base [active] 1091500000673 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1091500000674 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1091500000675 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1091500000676 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1091500000677 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1091500000678 Zn binding site [ion binding]; other site 1091500000679 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 1091500000680 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 1091500000681 putative active site [active] 1091500000682 PE family; Region: PE; pfam00934 1091500000683 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1091500000684 PPE family; Region: PPE; pfam00823 1091500000685 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1091500000686 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 1091500000687 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1091500000688 Walker A motif; other site 1091500000689 ATP binding site [chemical binding]; other site 1091500000690 Walker B motif; other site 1091500000691 arginine finger; other site 1091500000692 Protein of unknown function (DUF690); Region: DUF690; pfam05108 1091500000693 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1091500000694 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1091500000695 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1091500000696 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1091500000697 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1091500000698 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1091500000699 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1091500000700 PPE family; Region: PPE; pfam00823 1091500000701 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1091500000702 EspG family; Region: ESX-1_EspG; pfam14011 1091500000703 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 1091500000704 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 1091500000705 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1091500000706 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 1091500000707 active site 1091500000708 catalytic residues [active] 1091500000709 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 1091500000710 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1091500000711 Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752 1091500000712 potential frameshift: common BLAST hit: gi|340625332|ref|YP_004743784.1| putative TRANS-ACONITATE methyltransferase TAM 1091500000713 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4424 1091500000714 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1091500000715 Sulfatase; Region: Sulfatase; cl17466 1091500000716 hypothetical protein; Region: PHA01748 1091500000717 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 1091500000718 putative active site [active] 1091500000719 light-dependent protochlorophyllide reductase (LPOR)-like, classical (c)-like SDRs; Region: LPOR_like_SDR_c_like; cd09810 1091500000720 protochlorophyllide reductase; Region: PLN00015 1091500000721 putative NAD(P) binding site [chemical binding]; other site 1091500000722 active site 1091500000723 potential frameshift: common BLAST hit: gi|253797231|ref|YP_003030232.1| PPE family protein 1091500000724 potential frameshift: common BLAST hit: gi|253797231|ref|YP_003030232.1| PPE family protein 1091500000725 potential frameshift: common BLAST hit: gi|15839689|ref|NP_334726.1| PPE family protein 1091500000726 potential frameshift: common BLAST hit: gi|253797231|ref|YP_003030232.1| PPE family protein 1091500000727 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1091500000728 FMN binding site [chemical binding]; other site 1091500000729 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1091500000730 dimer interface [polypeptide binding]; other site 1091500000731 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1091500000732 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1091500000733 active site 1091500000734 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 1091500000735 SnoaL-like domain; Region: SnoaL_4; pfam13577 1091500000736 SnoaL-like domain; Region: SnoaL_3; pfam13474 1091500000737 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 1091500000738 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1091500000739 nucleotide binding site [chemical binding]; other site 1091500000740 Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones]; Region: HtpG; COG0326 1091500000741 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 1091500000742 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 1091500000743 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 1091500000744 active site 1091500000745 catalytic residues [active] 1091500000746 Muconolactone delta-isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CatC1; COG4829 1091500000747 Muconolactone delta-isomerase; Region: MIase; cl01992 1091500000748 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 1091500000749 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 1091500000750 putative active site [active] 1091500000751 catalytic site [active] 1091500000752 putative metal binding site [ion binding]; other site 1091500000753 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 1091500000754 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 1091500000755 putative substrate binding pocket [chemical binding]; other site 1091500000756 AC domain interface; other site 1091500000757 catalytic triad [active] 1091500000758 AB domain interface; other site 1091500000759 interchain disulfide; other site 1091500000760 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1091500000761 trimer interface [polypeptide binding]; other site 1091500000762 active site 1091500000763 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1091500000764 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1091500000765 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1091500000766 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 1091500000767 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1091500000768 dimerization interface [polypeptide binding]; other site 1091500000769 putative DNA binding site [nucleotide binding]; other site 1091500000770 putative Zn2+ binding site [ion binding]; other site 1091500000771 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1091500000772 active site residue [active] 1091500000773 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1091500000774 Cytochrome P450; Region: p450; cl12078 1091500000775 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 1091500000776 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1091500000777 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1091500000778 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1091500000779 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091500000780 S-adenosylmethionine binding site [chemical binding]; other site 1091500000781 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1091500000782 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1091500000783 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1091500000784 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1091500000785 MDMPI C-terminal domain; Region: MDMPI_C; pfam07398 1091500000786 SnoaL-like domain; Region: SnoaL_2; pfam12680 1091500000787 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1091500000788 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1091500000789 substrate binding site; other site 1091500000790 tetramer interface; other site 1091500000791 PE family; Region: PE; pfam00934 1091500000792 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1091500000793 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1091500000794 active site 1091500000795 aminotransferase AlaT; Validated; Region: PRK09265 1091500000796 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1091500000797 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1091500000798 homodimer interface [polypeptide binding]; other site 1091500000799 catalytic residue [active] 1091500000800 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1091500000801 4Fe-4S binding domain; Region: Fer4; pfam00037 1091500000802 Cysteine-rich domain; Region: CCG; pfam02754 1091500000803 Cysteine-rich domain; Region: CCG; pfam02754 1091500000804 potential frameshift: common BLAST hit: gi|339630411|ref|YP_004722053.1| transcriptional regulator 1091500000805 potential frameshift: common BLAST hit: gi|253797267|ref|YP_003030268.1| isoniazid inducible protein iniB 1091500000806 KicB killing factor; Region: KicB; cl11468 1091500000807 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 1091500000808 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1091500000809 G1 box; other site 1091500000810 GTP/Mg2+ binding site [chemical binding]; other site 1091500000811 G2 box; other site 1091500000812 Switch I region; other site 1091500000813 G3 box; other site 1091500000814 Switch II region; other site 1091500000815 Uncharacterized MobA-related protein [General function prediction only]; Region: COG2068 1091500000816 active site 1091500000817 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1091500000818 TIGR04255 family protein; Region: sporadTIGR04255 1091500000819 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1091500000820 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1091500000821 nucleotide binding site [chemical binding]; other site 1091500000822 NEF interaction site [polypeptide binding]; other site 1091500000823 SBD interface [polypeptide binding]; other site 1091500000824 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 1091500000825 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1091500000826 dimer interface [polypeptide binding]; other site 1091500000827 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1091500000828 chaperone protein DnaJ; Provisional; Region: PRK14279 1091500000829 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1091500000830 HSP70 interaction site [polypeptide binding]; other site 1091500000831 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1091500000832 Zn binding sites [ion binding]; other site 1091500000833 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1091500000834 dimer interface [polypeptide binding]; other site 1091500000835 Helix-Turn-Helix DNA binding domain of HspR-like transcription regulators; Region: HTH_HspR-like; cd01279 1091500000836 DNA binding residues [nucleotide binding] 1091500000837 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1091500000838 putative dimer interface [polypeptide binding]; other site 1091500000839 potential frameshift: common BLAST hit: gi|224988740|ref|YP_002643427.1| PPE family protein 1091500000840 potential frameshift: common BLAST hit: gi|148821551|ref|YP_001286305.1| PPE family protein 1091500000841 potential frameshift: common BLAST hit: gi|224988740|ref|YP_002643427.1| PPE family protein 1091500000842 potential frameshift: common BLAST hit: gi|224988740|ref|YP_002643427.1| PPE family protein 1091500000843 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1091500000844 CoenzymeA binding site [chemical binding]; other site 1091500000845 subunit interaction site [polypeptide binding]; other site 1091500000846 PHB binding site; other site 1091500000847 potential frameshift: common BLAST hit: gi|339630427|ref|YP_004722069.1| adenylosuccinate synthetase 1091500000848 potential frameshift: common BLAST hit: gi|148821555|ref|YP_001286309.1| integral membrane protein 1091500000849 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 1091500000850 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1091500000851 MgtE intracellular N domain; Region: MgtE_N; pfam03448 1091500000852 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1091500000853 Divalent cation transporter; Region: MgtE; pfam01769 1091500000854 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1091500000855 fructose-bisphosphate aldolase, class II, yeast/E. coli subtype; Region: FruBisAldo_II_A; TIGR01520 1091500000856 active site 1091500000857 intersubunit interface [polypeptide binding]; other site 1091500000858 zinc binding site [ion binding]; other site 1091500000859 Na+ binding site [ion binding]; other site 1091500000860 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1091500000861 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1091500000862 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 1091500000863 AAA domain; Region: AAA_33; pfam13671 1091500000864 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 1091500000865 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 1091500000866 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 1091500000867 putative hydrophobic ligand binding site [chemical binding]; other site 1091500000868 MoxR-like ATPases [General function prediction only]; Region: COG0714 1091500000869 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 1091500000870 Ligand binding site; other site 1091500000871 metal-binding site 1091500000872 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 1091500000873 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1091500000874 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1091500000875 carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416 1091500000876 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 1091500000877 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1091500000878 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1091500000879 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1091500000880 catalytic loop [active] 1091500000881 iron binding site [ion binding]; other site 1091500000882 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1091500000883 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 1091500000884 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 1091500000885 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1091500000886 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 1091500000887 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1091500000888 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1091500000889 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1091500000890 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1091500000891 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1091500000892 dimerization interface [polypeptide binding]; other site 1091500000893 Uncharacterized conserved protein [Function unknown]; Region: COG3360 1091500000894 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1091500000895 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1091500000896 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1091500000897 active site 1091500000898 potential frameshift: common BLAST hit: gi|339630454|ref|YP_004722096.1| endopeptidase ATP-binding protein subunit B 1091500000899 potential frameshift: common BLAST hit: gi|253797308|ref|YP_003030309.1| monooxygenase 1091500000900 potential frameshift: common BLAST hit: gi|31791563|ref|NP_854056.1| LuxR family transcriptional regulator 1091500000901 potential frameshift: common BLAST hit: gi|340625417|ref|YP_004743869.1| putative transcriptional regulatory protein 1091500000902 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1091500000903 PPE family; Region: PPE; pfam00823 1091500000904 Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase) [Nucleotide transport and metabolism]; Region: PurT; COG0027 1091500000905 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1091500000906 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 1091500000907 active site residue [active] 1091500000908 O-succinylhomoserine sulfhydrylase; Provisional; Region: PRK07810 1091500000909 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1091500000910 homodimer interface [polypeptide binding]; other site 1091500000911 substrate-cofactor binding pocket; other site 1091500000912 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1091500000913 catalytic residue [active] 1091500000914 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1091500000915 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1091500000916 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1091500000917 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1091500000918 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1091500000919 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1091500000920 active site 1091500000921 PLD-like domain; Region: PLDc_2; pfam13091 1091500000922 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1091500000923 Beta-lactamase; Region: Beta-lactamase; pfam00144 1091500000924 potential frameshift: common BLAST hit: gi|253797323|ref|YP_003030324.1| acyl-CoA dehydrogenase 1091500000925 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 1091500000926 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1091500000927 MMPL family; Region: MMPL; pfam03176 1091500000928 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1091500000929 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1091500000930 active site 1091500000931 CoA binding site [chemical binding]; other site 1091500000932 AMP binding site [chemical binding]; other site 1091500000933 potential frameshift: common BLAST hit: gi|253797328|ref|YP_003030329.1| membrane bound polyketide synthase pks6 1091500000934 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1091500000935 potential frameshift: common BLAST hit: gi|253797330|ref|YP_003030331.1| F420-dependent glucose-6-phosphate dehydrogenase 1091500000936 phosphate acetyltransferase; Reviewed; Region: PRK05632 1091500000937 DRTGG domain; Region: DRTGG; pfam07085 1091500000938 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1091500000939 propionate/acetate kinase; Provisional; Region: PRK12379 1091500000940 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1091500000941 potential frameshift: common BLAST hit: gi|253797333|ref|YP_003030334.1| serine/threonine-protein kinase pknG 1091500000942 potential frameshift: common BLAST hit: gi|340625436|ref|YP_004743888.1| putative glutamine-binding lipoprotein GLNH (GLNBP) 1091500000943 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1091500000944 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1091500000945 thiamine phosphate binding site [chemical binding]; other site 1091500000946 active site 1091500000947 pyrophosphate binding site [ion binding]; other site 1091500000948 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1091500000949 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1091500000950 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1091500000951 thiS-thiF/thiG interaction site; other site 1091500000952 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1091500000953 ThiS interaction site; other site 1091500000954 putative active site [active] 1091500000955 tetramer interface [polypeptide binding]; other site 1091500000956 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 1091500000957 potential frameshift: common BLAST hit: gi|340625443|ref|YP_004743895.1| putative lipoprotein aminopeptidase LPQL 1091500000958 Predicted metalloprotease [General function prediction only]; Region: COG2321 1091500000959 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1091500000960 Zn binding site [ion binding]; other site 1091500000961 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1091500000962 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1091500000963 dimer interface [polypeptide binding]; other site 1091500000964 substrate binding site [chemical binding]; other site 1091500000965 ATP binding site [chemical binding]; other site 1091500000966 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1091500000967 ThiC-associated domain; Region: ThiC-associated; pfam13667 1091500000968 ThiC family; Region: ThiC; pfam01964 1091500000969 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1091500000970 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 1091500000971 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1091500000972 motif II; other site 1091500000973 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1091500000974 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1091500000975 putative catalytic site [active] 1091500000976 putative phosphate binding site [ion binding]; other site 1091500000977 putative metal binding site [ion binding]; other site 1091500000978 potential frameshift: common BLAST hit: gi|340625454|ref|YP_004743906.1| putative polypeptide deformylase DEF 1091500000979 potential frameshift: common BLAST hit: gi|340625454|ref|YP_004743906.1| putative polypeptide deformylase DEF 1091500000980 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 1091500000981 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 1091500000982 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1091500000983 E-class dimer interface [polypeptide binding]; other site 1091500000984 P-class dimer interface [polypeptide binding]; other site 1091500000985 active site 1091500000986 Cu2+ binding site [ion binding]; other site 1091500000987 Zn2+ binding site [ion binding]; other site 1091500000988 potential frameshift: common BLAST hit: gi|15839820|ref|NP_334857.1| carboxylate-amine ligase 1091500000989 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 1091500000990 AAA family ATPase, CDC48 subfamily; Region: CDC48; TIGR01243 1091500000991 Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359 1091500000992 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1091500000993 Walker A motif; other site 1091500000994 ATP binding site [chemical binding]; other site 1091500000995 Walker B motif; other site 1091500000996 arginine finger; other site 1091500000997 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1091500000998 Walker A motif; other site 1091500000999 ATP binding site [chemical binding]; other site 1091500001000 Walker B motif; other site 1091500001001 arginine finger; other site 1091500001002 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 1091500001003 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 1091500001004 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1091500001005 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1091500001006 dimer interface [polypeptide binding]; other site 1091500001007 putative functional site; other site 1091500001008 putative MPT binding site; other site 1091500001009 short chain dehydrogenase; Provisional; Region: PRK06197 1091500001010 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 1091500001011 putative NAD(P) binding site [chemical binding]; other site 1091500001012 active site 1091500001013 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1091500001014 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1091500001015 ring oligomerisation interface [polypeptide binding]; other site 1091500001016 ATP/Mg binding site [chemical binding]; other site 1091500001017 stacking interactions; other site 1091500001018 hinge regions; other site 1091500001019 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1091500001020 PPE family; Region: PPE; pfam00823 1091500001021 Protein of unknown function (DUF664); Region: DUF664; pfam04978 1091500001022 DinB superfamily; Region: DinB_2; pfam12867 1091500001023 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 1091500001024 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1091500001025 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1091500001026 DNA binding residues [nucleotide binding] 1091500001027 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 1091500001028 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 1091500001029 potential frameshift: common BLAST hit: gi|339630515|ref|YP_004722157.1| cyclopropane-fatty-acyl-phospholipid synthase 1091500001030 Uncharacterized conserved protein [Function unknown]; Region: COG3496 1091500001031 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 1091500001032 Subunit A of Class III extradiol dioxygenases; Region: Extradiol_Dioxygenase_3A_like; cl06673 1091500001033 dimer interface [polypeptide binding]; other site 1091500001034 Transport protein; Region: actII; TIGR00833 1091500001035 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1091500001036 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1091500001037 potential frameshift: common BLAST hit: gi|339630521|ref|YP_004722163.1| PPE family protein 1091500001038 Protein of unknown function (DUF2782); Region: DUF2782; pfam11191 1091500001039 enoyl-CoA hydratase; Provisional; Region: PRK12478 1091500001040 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1091500001041 trimer interface [polypeptide binding]; other site 1091500001042 oxyanion hole (OAH) forming residues; other site 1091500001043 PemK-like protein; Region: PemK; pfam02452 1091500001044 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 1091500001045 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1091500001046 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 1091500001047 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1091500001048 NAD(P) binding site [chemical binding]; other site 1091500001049 catalytic residues [active] 1091500001050 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3564 1091500001051 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 1091500001052 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1091500001053 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1091500001054 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1091500001055 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1091500001056 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1091500001057 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1091500001058 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1091500001059 non-specific DNA binding site [nucleotide binding]; other site 1091500001060 salt bridge; other site 1091500001061 sequence-specific DNA binding site [nucleotide binding]; other site 1091500001062 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 1091500001063 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1091500001064 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 1091500001065 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 1091500001066 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1091500001067 active site 1091500001068 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1091500001069 active site 2 [active] 1091500001070 isocitrate lyase; Provisional; Region: PRK15063 1091500001071 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cd06556 1091500001072 oligomerization interface [polypeptide binding]; other site 1091500001073 active site 1091500001074 metal binding site [ion binding]; metal-binding site 1091500001075 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 1091500001076 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1091500001077 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1091500001078 potential frameshift: common BLAST hit: gi|253797396|ref|YP_003030397.1| mycolic acid synthase umaA 1091500001079 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1091500001080 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1091500001081 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091500001082 S-adenosylmethionine binding site [chemical binding]; other site 1091500001083 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224 1091500001084 UbiA prenyltransferase family; Region: UbiA; pfam01040 1091500001085 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1091500001086 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1091500001087 Predicted membrane protein [Function unknown]; Region: COG2733 1091500001088 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1091500001089 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1091500001090 non-specific DNA binding site [nucleotide binding]; other site 1091500001091 salt bridge; other site 1091500001092 sequence-specific DNA binding site [nucleotide binding]; other site 1091500001093 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 1091500001094 Protein of unknown function (DUF2599); Region: DUF2599; pfam10783 1091500001095 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1091500001096 intersubunit interface [polypeptide binding]; other site 1091500001097 active site 1091500001098 catalytic residue [active] 1091500001099 potential frameshift: common BLAST hit: gi|340625506|ref|YP_004743958.1| putative AMIDOhydrolase 1091500001100 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1091500001101 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 1091500001102 catalytic triad [active] 1091500001103 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 1091500001104 potential frameshift: common BLAST hit: gi|340625508|ref|YP_004743960.1| putative UDP-N-acetylenolpyruvoylglucosamine reductase MURB 1091500001105 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 1091500001106 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1091500001107 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 1091500001108 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1091500001109 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1091500001110 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1091500001111 NAD(P) binding site [chemical binding]; other site 1091500001112 active site 1091500001113 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1091500001114 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1091500001115 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 1091500001116 putative ADP-binding pocket [chemical binding]; other site 1091500001117 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1091500001118 L-lysine exporter; Region: 2a75; TIGR00948 1091500001119 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1091500001120 catalytic core [active] 1091500001121 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 1091500001122 potential frameshift: common BLAST hit: gi|340625516|ref|YP_004743968.1| putative two component sensor histidine kinase SENX3 1091500001123 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1091500001124 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091500001125 active site 1091500001126 phosphorylation site [posttranslational modification] 1091500001127 intermolecular recognition site; other site 1091500001128 dimerization interface [polypeptide binding]; other site 1091500001129 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1091500001130 DNA binding site [nucleotide binding] 1091500001131 potential frameshift: common BLAST hit: gi|339630562|ref|YP_004722204.1| oxidoreductase 1091500001132 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1091500001133 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1091500001134 DNA-binding site [nucleotide binding]; DNA binding site 1091500001135 FCD domain; Region: FCD; pfam07729 1091500001136 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1091500001137 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1091500001138 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1091500001139 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1091500001140 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1091500001141 Diacylglycerol kinase catalytic domain (presumed); Region: DAGKc; smart00046 1091500001142 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1091500001143 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 1091500001144 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1091500001145 DNA binding domain, excisionase family; Region: excise; TIGR01764 1091500001146 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1091500001147 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 1091500001148 putative NAD(P) binding site [chemical binding]; other site 1091500001149 active site 1091500001150 putative substrate binding site [chemical binding]; other site 1091500001151 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1091500001152 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 1091500001153 putative acyl-acceptor binding pocket; other site 1091500001154 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1091500001155 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1091500001156 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091500001157 S-adenosylmethionine binding site [chemical binding]; other site 1091500001158 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1091500001159 HAD-superfamily subfamily IB hydrolase, TIGR01490; Region: HAD-SF-IB-hyp1 1091500001160 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1091500001161 potential frameshift: common BLAST hit: gi|253797439|ref|YP_003030440.1| transmembrane transporter mmpL2 1091500001162 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 1091500001163 glutamyl-tRNA reductase; Region: hemA; TIGR01035 1091500001164 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1091500001165 tRNA; other site 1091500001166 putative tRNA binding site [nucleotide binding]; other site 1091500001167 putative NADP binding site [chemical binding]; other site 1091500001168 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1091500001169 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1091500001170 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1091500001171 domain interfaces; other site 1091500001172 active site 1091500001173 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 1091500001174 active site 1091500001175 homodimer interface [polypeptide binding]; other site 1091500001176 SAM binding site [chemical binding]; other site 1091500001177 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1091500001178 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1091500001179 active site 1091500001180 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1091500001181 dimer interface [polypeptide binding]; other site 1091500001182 active site 1091500001183 Schiff base residues; other site 1091500001184 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1091500001185 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1091500001186 active site 1091500001187 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1091500001188 anti sigma factor interaction site; other site 1091500001189 regulatory phosphorylation site [posttranslational modification]; other site 1091500001190 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1091500001191 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1091500001192 active site 1091500001193 catalytic triad [active] 1091500001194 oxyanion hole [active] 1091500001195 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 1091500001196 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091500001197 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1091500001198 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1091500001199 potential frameshift: common BLAST hit: gi|339630596|ref|YP_004722238.1| glutamate-1-semialdehyde 2,1-aminomutase 1091500001200 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1091500001201 catalytic core [active] 1091500001202 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1091500001203 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1091500001204 catalytic residues [active] 1091500001205 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1091500001206 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1091500001207 potential frameshift: common BLAST hit: gi|224988918|ref|YP_002643605.1| transmembrane protein 1091500001208 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 1091500001209 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1091500001210 AAA domain; Region: AAA_31; pfam13614 1091500001211 P-loop; other site 1091500001212 Magnesium ion binding site [ion binding]; other site 1091500001213 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1091500001214 Protein of unknown function (DUF4229); Region: DUF4229; pfam14012 1091500001215 3-oxoacyl-(acyl-carrier-protein) synthase III; Region: fabH; TIGR00747 1091500001216 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1091500001217 dimer interface [polypeptide binding]; other site 1091500001218 active site 1091500001219 CoA binding pocket [chemical binding]; other site 1091500001220 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Region: menA; TIGR00751 1091500001221 UbiA prenyltransferase family; Region: UbiA; pfam01040 1091500001222 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1091500001223 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1091500001224 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1091500001225 NAD(P) binding site [chemical binding]; other site 1091500001226 active site 1091500001227 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1091500001228 Ligand binding site; other site 1091500001229 Putative Catalytic site; other site 1091500001230 DXD motif; other site 1091500001231 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3222 1091500001232 potential frameshift: common BLAST hit: gi|340625568|ref|YP_004744020.1| putative integral membrane protein 1091500001233 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 1091500001234 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1091500001235 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1091500001236 acyl-activating enzyme (AAE) consensus motif; other site 1091500001237 acyl-activating enzyme (AAE) consensus motif; other site 1091500001238 AMP binding site [chemical binding]; other site 1091500001239 active site 1091500001240 CoA binding site [chemical binding]; other site 1091500001241 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 1091500001242 potential frameshift: common BLAST hit: gi|339630616|ref|YP_004722258.1| inorganic phosphate transporter 1091500001243 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1091500001244 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1091500001245 active site 1091500001246 short chain dehydrogenase; Provisional; Region: PRK05866 1091500001247 classical (c) SDRs; Region: SDR_c; cd05233 1091500001248 NAD(P) binding site [chemical binding]; other site 1091500001249 active site 1091500001250 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1091500001251 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1091500001252 substrate binding site [chemical binding]; other site 1091500001253 oxyanion hole (OAH) forming residues; other site 1091500001254 trimer interface [polypeptide binding]; other site 1091500001255 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 1091500001256 putative active site [active] 1091500001257 homotetrameric interface [polypeptide binding]; other site 1091500001258 metal binding site [ion binding]; metal-binding site 1091500001259 Post-segregation antitoxin (ccd killing mechanism protein) encoded by the F plasmid [General function prediction only]; Region: COG5302 1091500001260 potential frameshift: common BLAST hit: gi|339630621|ref|YP_004722263.1| fatty-acid-CoA ligase 1091500001261 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1091500001262 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1091500001263 active site 1091500001264 O-succinylbenzoate synthase; Provisional; Region: PRK02901 1091500001265 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 1091500001266 active site 1091500001267 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1091500001268 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1091500001269 TAP-like protein; Region: Abhydrolase_4; pfam08386 1091500001270 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 1091500001271 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1091500001272 TPP-binding site; other site 1091500001273 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 1091500001274 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1091500001275 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1091500001276 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1091500001277 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091500001278 S-adenosylmethionine binding site [chemical binding]; other site 1091500001279 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1091500001280 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091500001281 S-adenosylmethionine binding site [chemical binding]; other site 1091500001282 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 1091500001283 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1091500001284 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1091500001285 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1091500001286 substrate binding pocket [chemical binding]; other site 1091500001287 chain length determination region; other site 1091500001288 substrate-Mg2+ binding site; other site 1091500001289 catalytic residues [active] 1091500001290 aspartate-rich region 1; other site 1091500001291 active site lid residues [active] 1091500001292 aspartate-rich region 2; other site 1091500001293 heat shock protein HtpX; Provisional; Region: PRK03072 1091500001294 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK12439 1091500001295 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1091500001296 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1091500001297 potential frameshift: common BLAST hit: gi|253797497|ref|YP_003030498.1| monooxygenase 1091500001298 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 1091500001299 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1091500001300 O-methyltransferase; Region: Methyltransf_2; pfam00891 1091500001301 potential frameshift: common BLAST hit: gi|339630638|ref|YP_004722280.1| cytochrome P450 1091500001302 potential frameshift: common BLAST hit: gi|224988958|ref|YP_002643645.1| cytochrome p450 135b1 1091500001303 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 1091500001304 potential frameshift: common BLAST hit: gi|253797502|ref|YP_003030503.1| ribonucleoside-diphosphate reductase large subunit nrdZ 1091500001305 nicotinate phosphoribosyltransferase; Provisional; Region: PRK12484 1091500001306 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1091500001307 active site 1091500001308 Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane]; Region: PgsA; COG2843 1091500001309 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 1091500001310 putative active site [active] 1091500001311 putative metal binding site [ion binding]; other site 1091500001312 hypothetical protein; Provisional; Region: PRK07588 1091500001313 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1091500001314 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1091500001315 dimerization interface [polypeptide binding]; other site 1091500001316 putative DNA binding site [nucleotide binding]; other site 1091500001317 putative Zn2+ binding site [ion binding]; other site 1091500001318 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1091500001319 putative hydrophobic ligand binding site [chemical binding]; other site 1091500001320 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1091500001321 TIGR03086 family protein; Region: TIGR03086 1091500001322 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1091500001323 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1091500001324 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1091500001325 potential frameshift: common BLAST hit: gi|121636496|ref|YP_976719.1| PE-PGRS family protein 1091500001326 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1091500001327 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 1091500001328 putative active site [active] 1091500001329 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 1091500001330 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 1091500001331 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 1091500001332 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 1091500001333 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1091500001334 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1091500001335 DNA-binding site [nucleotide binding]; DNA binding site 1091500001336 FCD domain; Region: FCD; pfam07729 1091500001337 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1091500001338 Permease; Region: Permease; pfam02405 1091500001339 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1091500001340 Permease; Region: Permease; pfam02405 1091500001341 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1091500001342 mce related protein; Region: MCE; pfam02470 1091500001343 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1091500001344 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1091500001345 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1091500001346 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1091500001347 mce related protein; Region: MCE; pfam02470 1091500001348 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1091500001349 mce related protein; Region: MCE; pfam02470 1091500001350 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1091500001351 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1091500001352 mce related protein; Region: MCE; pfam02470 1091500001353 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1091500001354 mce related protein; Region: MCE; pfam02470 1091500001355 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1091500001356 oligomeric interface; other site 1091500001357 putative active site [active] 1091500001358 homodimer interface [polypeptide binding]; other site 1091500001359 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1091500001360 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 1091500001361 AAA domain; Region: AAA_14; pfam13173 1091500001362 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1091500001363 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 1091500001364 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1091500001365 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1091500001366 ATP binding site [chemical binding]; other site 1091500001367 Mg2+ binding site [ion binding]; other site 1091500001368 G-X-G motif; other site 1091500001369 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1091500001370 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091500001371 active site 1091500001372 phosphorylation site [posttranslational modification] 1091500001373 intermolecular recognition site; other site 1091500001374 dimerization interface [polypeptide binding]; other site 1091500001375 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1091500001376 DNA binding site [nucleotide binding] 1091500001377 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 1091500001378 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 1091500001379 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 1091500001380 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 1091500001381 catalytic residues [active] 1091500001382 catalytic nucleophile [active] 1091500001383 potential frameshift: common BLAST hit: gi|339630674|ref|YP_004722316.1| transposase 1091500001384 Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704 1091500001385 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 1091500001386 putative active site [active] 1091500001387 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB-like; cd09875 1091500001388 putative active site [active] 1091500001389 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 1091500001390 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 1091500001391 nucleotide binding site/active site [active] 1091500001392 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 1091500001393 galactokinase; Provisional; Region: PRK00555 1091500001394 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1091500001395 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1091500001396 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4423 1091500001397 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 1091500001398 putative active site [active] 1091500001399 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1091500001400 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1091500001401 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1091500001402 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1091500001403 oligomeric interface; other site 1091500001404 putative active site [active] 1091500001405 homodimer interface [polypeptide binding]; other site 1091500001406 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398 1091500001407 FIST N domain; Region: FIST; pfam08495 1091500001408 FIST C domain; Region: FIST_C; pfam10442 1091500001409 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 1091500001410 AAA domain; Region: AAA_30; pfam13604 1091500001411 Family description; Region: UvrD_C_2; pfam13538 1091500001412 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 1091500001413 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1091500001414 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 1091500001415 potential frameshift: common BLAST hit: gi|253797569|ref|YP_003030570.1| exonuclease subunit V gamma recC 1091500001416 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1091500001417 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1091500001418 substrate binding site [chemical binding]; other site 1091500001419 oxyanion hole (OAH) forming residues; other site 1091500001420 trimer interface [polypeptide binding]; other site 1091500001421 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1091500001422 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 1091500001423 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 1091500001424 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1091500001425 active site 1091500001426 catalytic site [active] 1091500001427 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1091500001428 active site 1091500001429 catalytic site [active] 1091500001430 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 1091500001431 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1091500001432 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1091500001433 putative homodimer interface [polypeptide binding]; other site 1091500001434 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1091500001435 heterodimer interface [polypeptide binding]; other site 1091500001436 homodimer interface [polypeptide binding]; other site 1091500001437 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1091500001438 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1091500001439 23S rRNA interface [nucleotide binding]; other site 1091500001440 L7/L12 interface [polypeptide binding]; other site 1091500001441 putative thiostrepton binding site; other site 1091500001442 L25 interface [polypeptide binding]; other site 1091500001443 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1091500001444 mRNA/rRNA interface [nucleotide binding]; other site 1091500001445 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1091500001446 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091500001447 S-adenosylmethionine binding site [chemical binding]; other site 1091500001448 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1091500001449 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1091500001450 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091500001451 S-adenosylmethionine binding site [chemical binding]; other site 1091500001452 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1091500001453 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1091500001454 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091500001455 S-adenosylmethionine binding site [chemical binding]; other site 1091500001456 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1091500001457 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1091500001458 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091500001459 S-adenosylmethionine binding site [chemical binding]; other site 1091500001460 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1091500001461 TAP-like protein; Region: Abhydrolase_4; pfam08386 1091500001462 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1091500001463 ABC1 family; Region: ABC1; cl17513 1091500001464 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1091500001465 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1091500001466 potential frameshift: common BLAST hit: gi|340625670|ref|YP_004744122.1| putative 50S ribosomal protein L10 RPLJ 1091500001467 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1091500001468 core dimer interface [polypeptide binding]; other site 1091500001469 peripheral dimer interface [polypeptide binding]; other site 1091500001470 L10 interface [polypeptide binding]; other site 1091500001471 L11 interface [polypeptide binding]; other site 1091500001472 putative EF-Tu interaction site [polypeptide binding]; other site 1091500001473 putative EF-G interaction site [polypeptide binding]; other site 1091500001474 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1091500001475 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1091500001476 WHG domain; Region: WHG; pfam13305 1091500001477 Retinal pigment epithelial membrane protein; Region: RPE65; cl10080 1091500001478 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1091500001479 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1091500001480 Walker A/P-loop; other site 1091500001481 ATP binding site [chemical binding]; other site 1091500001482 Q-loop/lid; other site 1091500001483 ABC transporter signature motif; other site 1091500001484 Walker B; other site 1091500001485 D-loop; other site 1091500001486 H-loop/switch region; other site 1091500001487 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1091500001488 putative active site [active] 1091500001489 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 1091500001490 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 1091500001491 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG1848 1091500001492 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1091500001493 Sulfatase; Region: Sulfatase; pfam00884 1091500001494 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1091500001495 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1091500001496 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1091500001497 putative active site [active] 1091500001498 potential frameshift: common BLAST hit: gi|148821872|ref|YP_001286626.1| DNA-directed RNA polymerase subunit beta 1091500001499 potential frameshift: common BLAST hit: gi|339630738|ref|YP_004722380.1| DNA-directed RNA polymerase subunit beta' 1091500001500 potential frameshift: common BLAST hit: gi|15840071|ref|NP_335108.1| DNA-directed RNA polymerase subunit beta' 1091500001501 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; pfam04734 1091500001502 potential frameshift: common BLAST hit: gi|339630740|ref|YP_004722382.1| endonuclease IV 1091500001503 potential frameshift: common BLAST hit: gi|224989064|ref|YP_002643751.1| lipoprotein 1091500001504 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 1091500001505 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1091500001506 active site 1091500001507 potential frameshift: common BLAST hit: gi|340625692|ref|YP_004744144.1| putative enoyl-CoA hydratase ECHA4 1091500001508 Phenylacetic acid-responsive transcriptional repressor [Transcription]; Region: PaaX; COG3327 1091500001509 PaaX-like protein; Region: PaaX; pfam07848 1091500001510 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 1091500001511 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1091500001512 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1091500001513 substrate binding site [chemical binding]; other site 1091500001514 oxyanion hole (OAH) forming residues; other site 1091500001515 trimer interface [polypeptide binding]; other site 1091500001516 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1091500001517 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1091500001518 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 1091500001519 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 1091500001520 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1091500001521 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1091500001522 WHG domain; Region: WHG; pfam13305 1091500001523 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1091500001524 S17 interaction site [polypeptide binding]; other site 1091500001525 S8 interaction site; other site 1091500001526 16S rRNA interaction site [nucleotide binding]; other site 1091500001527 streptomycin interaction site [chemical binding]; other site 1091500001528 23S rRNA interaction site [nucleotide binding]; other site 1091500001529 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1091500001530 30S ribosomal protein S7; Validated; Region: PRK05302 1091500001531 potential frameshift: common BLAST hit: gi|340625703|ref|YP_004744155.1| putative elongation factor G FUSA1 (EF-G) 1091500001532 elongation factor Tu; Reviewed; Region: PRK00049 1091500001533 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1091500001534 G1 box; other site 1091500001535 GEF interaction site [polypeptide binding]; other site 1091500001536 GTP/Mg2+ binding site [chemical binding]; other site 1091500001537 Switch I region; other site 1091500001538 G2 box; other site 1091500001539 G3 box; other site 1091500001540 Switch II region; other site 1091500001541 G4 box; other site 1091500001542 G5 box; other site 1091500001543 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 1091500001544 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1091500001545 Antibiotic Binding Site [chemical binding]; other site 1091500001546 Short C-terminal domain; Region: SHOCT; pfam09851 1091500001547 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1091500001548 classical (c) SDRs; Region: SDR_c; cd05233 1091500001549 NAD(P) binding site [chemical binding]; other site 1091500001550 active site 1091500001551 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1091500001552 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1091500001553 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1091500001554 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1091500001555 putative mycofactocin binding protein MftB; Region: mycofact_MftB; TIGR03967 1091500001556 potential frameshift: common BLAST hit: gi|339630763|ref|YP_004722405.1| coenzyme PQQ synthesis protein E 1091500001557 potential frameshift: common BLAST hit: gi|340625713|ref|YP_004744165.1| putative L-lactate dehydrogenase (cytochrome) LLDD1 1091500001558 mycofactocin system creatininase family protein; Region: mycofact_creat; TIGR03964 1091500001559 mycofactocin system glycosyltransferase; Region: mycofact_glyco; TIGR03965 1091500001560 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1091500001561 Probable Catalytic site; other site 1091500001562 metal-binding site 1091500001563 dehydrogenase, Rv0697 family; Region: Rv0697; TIGR03970 1091500001564 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1091500001565 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1091500001566 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1091500001567 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1091500001568 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1091500001569 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1091500001570 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1091500001571 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1091500001572 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1091500001573 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1091500001574 putative translocon binding site; other site 1091500001575 protein-rRNA interface [nucleotide binding]; other site 1091500001576 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1091500001577 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1091500001578 G-X-X-G motif; other site 1091500001579 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1091500001580 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1091500001581 23S rRNA interface [nucleotide binding]; other site 1091500001582 5S rRNA interface [nucleotide binding]; other site 1091500001583 putative antibiotic binding site [chemical binding]; other site 1091500001584 L25 interface [polypeptide binding]; other site 1091500001585 L27 interface [polypeptide binding]; other site 1091500001586 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1091500001587 putative translocon interaction site; other site 1091500001588 signal recognition particle (SRP54) interaction site; other site 1091500001589 L23 interface [polypeptide binding]; other site 1091500001590 trigger factor interaction site; other site 1091500001591 23S rRNA interface [nucleotide binding]; other site 1091500001592 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1091500001593 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1091500001594 Sulfatase; Region: Sulfatase; pfam00884 1091500001595 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl17353 1091500001596 Uncharacterized conserved protein [Function unknown]; Region: COG1262 1091500001597 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1091500001598 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1091500001599 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1091500001600 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1091500001601 RNA binding site [nucleotide binding]; other site 1091500001602 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1091500001603 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1091500001604 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1091500001605 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 1091500001606 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1091500001607 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1091500001608 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1091500001609 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1091500001610 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1091500001611 5S rRNA interface [nucleotide binding]; other site 1091500001612 23S rRNA interface [nucleotide binding]; other site 1091500001613 L5 interface [polypeptide binding]; other site 1091500001614 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1091500001615 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1091500001616 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1091500001617 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1091500001618 23S rRNA binding site [nucleotide binding]; other site 1091500001619 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1091500001620 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 1091500001621 tandem repeat interface [polypeptide binding]; other site 1091500001622 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1091500001623 oligomer interface [polypeptide binding]; other site 1091500001624 active site residues [active] 1091500001625 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1091500001626 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1091500001627 tandem repeat interface [polypeptide binding]; other site 1091500001628 oligomer interface [polypeptide binding]; other site 1091500001629 active site residues [active] 1091500001630 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1091500001631 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1091500001632 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1091500001633 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1091500001634 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1091500001635 intersubunit interface [polypeptide binding]; other site 1091500001636 active site 1091500001637 Zn2+ binding site [ion binding]; other site 1091500001638 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1091500001639 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1091500001640 NAD binding site [chemical binding]; other site 1091500001641 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1091500001642 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1091500001643 nucleotide binding site [chemical binding]; other site 1091500001644 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1091500001645 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1091500001646 Coenzyme A binding pocket [chemical binding]; other site 1091500001647 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1091500001648 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1091500001649 potential frameshift: common BLAST hit: gi|340625753|ref|YP_004744205.1| putative preprotein translocase SECY 1091500001650 adenylate kinase; Reviewed; Region: adk; PRK00279 1091500001651 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1091500001652 AMP-binding site [chemical binding]; other site 1091500001653 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1091500001654 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1091500001655 active site 1091500001656 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 1091500001657 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1091500001658 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1091500001659 DNA binding residues [nucleotide binding] 1091500001660 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 1091500001661 Putative zinc-finger; Region: zf-HC2; pfam13490 1091500001662 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 1091500001663 PYR/PP interface [polypeptide binding]; other site 1091500001664 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1091500001665 MarR family; Region: MarR; pfam01047 1091500001666 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1091500001667 TIGR03086 family protein; Region: TIGR03086 1091500001668 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 1091500001669 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1091500001670 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1091500001671 Helix-turn-helix domain; Region: HTH_17; pfam12728 1091500001672 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 1091500001673 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 1091500001674 potential frameshift: common BLAST hit: gi|57116773|ref|YP_177750.1| PE-PGRS family protein 1091500001675 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1091500001676 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 1091500001677 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 1091500001678 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1091500001679 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1091500001680 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1091500001681 active site 1091500001682 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1091500001683 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1091500001684 tetrameric interface [polypeptide binding]; other site 1091500001685 NAD binding site [chemical binding]; other site 1091500001686 catalytic residues [active] 1091500001687 potential frameshift: common BLAST hit: gi|340625773|ref|YP_004744225.1| PE-PGRS family protein 1091500001688 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1091500001689 PPE family; Region: PPE; pfam00823 1091500001690 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1091500001691 Helix-turn-helix domain; Region: HTH_28; pfam13518 1091500001692 Winged helix-turn helix; Region: HTH_29; pfam13551 1091500001693 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1091500001694 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091500001695 active site 1091500001696 phosphorylation site [posttranslational modification] 1091500001697 intermolecular recognition site; other site 1091500001698 dimerization interface [polypeptide binding]; other site 1091500001699 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1091500001700 DNA binding site [nucleotide binding] 1091500001701 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1091500001702 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1091500001703 dimerization interface [polypeptide binding]; other site 1091500001704 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1091500001705 dimer interface [polypeptide binding]; other site 1091500001706 phosphorylation site [posttranslational modification] 1091500001707 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1091500001708 ATP binding site [chemical binding]; other site 1091500001709 Mg2+ binding site [ion binding]; other site 1091500001710 G-X-G motif; other site 1091500001711 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 1091500001712 nucleotide binding site/active site [active] 1091500001713 HIT family signature motif; other site 1091500001714 catalytic residue [active] 1091500001715 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 1091500001716 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 1091500001717 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1091500001718 NAD binding site [chemical binding]; other site 1091500001719 catalytic Zn binding site [ion binding]; other site 1091500001720 substrate binding site [chemical binding]; other site 1091500001721 structural Zn binding site [ion binding]; other site 1091500001722 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1091500001723 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1091500001724 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 1091500001725 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1091500001726 Cytochrome P450; Region: p450; cl12078 1091500001727 short chain dehydrogenase; Provisional; Region: PRK07775 1091500001728 classical (c) SDRs; Region: SDR_c; cd05233 1091500001729 NAD(P) binding site [chemical binding]; other site 1091500001730 active site 1091500001731 potential frameshift: common BLAST hit: gi|339630836|ref|YP_004722478.1| cytochrome P450 1091500001732 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1091500001733 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 1091500001734 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 1091500001735 NAD binding site [chemical binding]; other site 1091500001736 catalytic residues [active] 1091500001737 short chain dehydrogenase; Provisional; Region: PRK07774 1091500001738 classical (c) SDRs; Region: SDR_c; cd05233 1091500001739 NAD(P) binding site [chemical binding]; other site 1091500001740 active site 1091500001741 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1091500001742 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 1091500001743 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1091500001744 potential frameshift: common BLAST hit: gi|339630842|ref|YP_004722484.1| phosphoribosylamine--glycine ligase 1091500001745 potential frameshift: common BLAST hit: gi|339630842|ref|YP_004722484.1| phosphoribosylamine--glycine ligase 1091500001746 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1091500001747 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1091500001748 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 1091500001749 Predicted nuclease (RNAse H fold) [General function prediction only]; Region: COG4328 1091500001750 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 1091500001751 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 1091500001752 tetramer interface [polypeptide binding]; other site 1091500001753 potential frameshift: common BLAST hit: gi|339630848|ref|YP_004722490.1| cytochrome P450 1091500001754 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 1091500001755 ATP binding site [chemical binding]; other site 1091500001756 active site 1091500001757 substrate binding site [chemical binding]; other site 1091500001758 potential frameshift: common BLAST hit: gi|339630851|ref|YP_004722493.1| oligopeptidase B 1091500001759 WHG domain; Region: WHG; pfam13305 1091500001760 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1091500001761 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1091500001762 putative substrate translocation pore; other site 1091500001763 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1091500001764 Predicted deacetylase [General function prediction only]; Region: COG3233 1091500001765 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374 1091500001766 putative active site [active] 1091500001767 putative Zn binding site [ion binding]; other site 1091500001768 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1091500001769 FAD binding domain; Region: FAD_binding_2; pfam00890 1091500001770 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1091500001771 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 1091500001772 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 1091500001773 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1091500001774 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1091500001775 putative active site [active] 1091500001776 catalytic triad [active] 1091500001777 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1091500001778 Transglutaminase/protease-like homologues; Region: TGc; smart00460 1091500001779 potential frameshift: common BLAST hit: gi|253797740|ref|YP_003030741.1| GntR family transcriptional regulator 1091500001780 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1091500001781 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 1091500001782 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1091500001783 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1091500001784 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1091500001785 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1091500001786 Transposase; Region: HTH_Tnp_1; cl17663 1091500001787 HTH-like domain; Region: HTH_21; pfam13276 1091500001788 Integrase core domain; Region: rve; pfam00665 1091500001789 Integrase core domain; Region: rve_3; pfam13683 1091500001790 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1091500001791 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1091500001792 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1091500001793 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1091500001794 Uncharacterized protein, linocin/CFP29 homolog [Function unknown]; Region: COG1659 1091500001795 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 1091500001796 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 1091500001797 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 1091500001798 active site 1091500001799 metal binding site [ion binding]; metal-binding site 1091500001800 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1091500001801 active site 1091500001802 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1091500001803 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1091500001804 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1091500001805 potential frameshift: common BLAST hit: gi|339630869|ref|YP_004722511.1| phosphoribosylformylglycinamidine synthase 1091500001806 potential frameshift: common BLAST hit: gi|339630869|ref|YP_004722511.1| phosphoribosylformylglycinamidine synthase 1091500001807 CAAX protease self-immunity; Region: Abi; pfam02517 1091500001808 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 1091500001809 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 1091500001810 active site 1091500001811 metal binding site [ion binding]; metal-binding site 1091500001812 hexamer interface [polypeptide binding]; other site 1091500001813 potential frameshift: common BLAST hit: gi|339630872|ref|YP_004722514.1| UDP-glucose-4-epimerase 1091500001814 amidophosphoribosyltransferase; Provisional; Region: PRK07847 1091500001815 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1091500001816 active site 1091500001817 tetramer interface [polypeptide binding]; other site 1091500001818 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1091500001819 active site 1091500001820 potential frameshift: common BLAST hit: gi|339630875|ref|YP_004722517.1| phosphoribosylformylglycinamidine cyclo-ligase 1091500001821 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 1091500001822 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1091500001823 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1091500001824 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1091500001825 catalytic residue [active] 1091500001826 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 1091500001827 heme-binding site [chemical binding]; other site 1091500001828 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 1091500001829 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1091500001830 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1091500001831 active site residue [active] 1091500001832 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1091500001833 active site residue [active] 1091500001834 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1091500001835 catalytic residues [active] 1091500001836 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1091500001837 potential frameshift: common BLAST hit: gi|339630884|ref|YP_004722526.1| transcriptional regulator 1091500001838 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 1091500001839 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1091500001840 Coenzyme A binding pocket [chemical binding]; other site 1091500001841 potential frameshift: common BLAST hit: gi|339630886|ref|YP_004722528.1| phosphate ABC transporter ATP-binding protein 1091500001842 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1091500001843 PhoU domain; Region: PhoU; pfam01895 1091500001844 PhoU domain; Region: PhoU; pfam01895 1091500001845 cell envelope-related function transcriptional attenuator common domain; Region: lytR_cpsA_psr; TIGR00350 1091500001846 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1091500001847 potential frameshift: common BLAST hit: gi|340625838|ref|YP_004744290.1| putative transcriptional regulatory protein 1091500001848 Fatty acid desaturase; Region: FA_desaturase_2; pfam03405 1091500001849 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 1091500001850 homodimer interface [polypeptide binding]; other site 1091500001851 putative substrate binding pocket [chemical binding]; other site 1091500001852 diiron center [ion binding]; other site 1091500001853 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1091500001854 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 1091500001855 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 1091500001856 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1091500001857 dimerization interface [polypeptide binding]; other site 1091500001858 putative DNA binding site [nucleotide binding]; other site 1091500001859 putative Zn2+ binding site [ion binding]; other site 1091500001860 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1091500001861 dimer interface [polypeptide binding]; other site 1091500001862 catalytic motif [active] 1091500001863 nucleoside/Zn binding site; other site 1091500001864 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1091500001865 PE family; Region: PE; pfam00934 1091500001866 potential frameshift: common BLAST hit: gi|148822040|ref|YP_001286794.1| PE-PGRS family protein 1091500001867 PknH-like extracellular domain; Region: PknH_C; pfam14032 1091500001868 Predicted nucleotidyltransferase [General function prediction only]; Region: COG4849 1091500001869 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4861 1091500001870 Uncharacterized protein conserved in bacteria (DUF2186); Region: DUF2186; pfam09952 1091500001871 D-ala-D-ala dipeptidase; Region: Peptidase_M15; pfam01427 1091500001872 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091500001873 S-adenosylmethionine binding site [chemical binding]; other site 1091500001874 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 1091500001875 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1091500001876 putative substrate translocation pore; other site 1091500001877 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1091500001878 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 1091500001879 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1091500001880 tetramer interface [polypeptide binding]; other site 1091500001881 TPP-binding site [chemical binding]; other site 1091500001882 heterodimer interface [polypeptide binding]; other site 1091500001883 phosphorylation loop region [posttranslational modification] 1091500001884 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1091500001885 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091500001886 active site 1091500001887 phosphorylation site [posttranslational modification] 1091500001888 intermolecular recognition site; other site 1091500001889 dimerization interface [polypeptide binding]; other site 1091500001890 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1091500001891 DNA binding residues [nucleotide binding] 1091500001892 dimerization interface [polypeptide binding]; other site 1091500001893 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1091500001894 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1091500001895 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1091500001896 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1091500001897 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1091500001898 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1091500001899 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1091500001900 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1091500001901 dimer interface [polypeptide binding]; other site 1091500001902 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1091500001903 catalytic residue [active] 1091500001904 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1091500001905 multidrug resistance protein MdtH; Provisional; Region: PRK11646 1091500001906 putative substrate translocation pore; other site 1091500001907 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 1091500001908 short chain dehydrogenase; Provisional; Region: PRK05876 1091500001909 classical (c) SDRs; Region: SDR_c; cd05233 1091500001910 NAD(P) binding site [chemical binding]; other site 1091500001911 active site 1091500001912 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1091500001913 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 1091500001914 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 1091500001915 dimer interface [polypeptide binding]; other site 1091500001916 PYR/PP interface [polypeptide binding]; other site 1091500001917 TPP binding site [chemical binding]; other site 1091500001918 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1091500001919 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 1091500001920 TPP-binding site [chemical binding]; other site 1091500001921 dimer interface [polypeptide binding]; other site 1091500001922 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1091500001923 putative hydrophobic ligand binding site [chemical binding]; other site 1091500001924 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1091500001925 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1091500001926 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1091500001927 putative hydrophobic ligand binding site [chemical binding]; other site 1091500001928 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1091500001929 putative hydrophobic ligand binding site [chemical binding]; other site 1091500001930 aminotransferase; Validated; Region: PRK07777 1091500001931 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1091500001932 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1091500001933 homodimer interface [polypeptide binding]; other site 1091500001934 catalytic residue [active] 1091500001935 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 1091500001936 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1091500001937 dimer interface [polypeptide binding]; other site 1091500001938 active site 1091500001939 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 1091500001940 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1091500001941 substrate binding site [chemical binding]; other site 1091500001942 oxyanion hole (OAH) forming residues; other site 1091500001943 trimer interface [polypeptide binding]; other site 1091500001944 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1091500001945 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 1091500001946 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1091500001947 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1091500001948 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1091500001949 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1091500001950 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1091500001951 ATP binding site [chemical binding]; other site 1091500001952 putative Mg++ binding site [ion binding]; other site 1091500001953 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1091500001954 nucleotide binding region [chemical binding]; other site 1091500001955 ATP-binding site [chemical binding]; other site 1091500001956 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1091500001957 trimer interface [polypeptide binding]; other site 1091500001958 dimer interface [polypeptide binding]; other site 1091500001959 putative active site [active] 1091500001960 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1091500001961 MPT binding site; other site 1091500001962 trimer interface [polypeptide binding]; other site 1091500001963 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1091500001964 MoaE homodimer interface [polypeptide binding]; other site 1091500001965 MoaD interaction [polypeptide binding]; other site 1091500001966 active site residues [active] 1091500001967 potential frameshift: common BLAST hit: gi|224989261|ref|YP_002643948.1| resuscitation-promoting factor 1091500001968 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1091500001969 MoaE interaction surface [polypeptide binding]; other site 1091500001970 MoeB interaction surface [polypeptide binding]; other site 1091500001971 thiocarboxylated glycine; other site 1091500001972 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1091500001973 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1091500001974 FeS/SAM binding site; other site 1091500001975 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1091500001976 potential frameshift: common BLAST hit: gi|339630936|ref|YP_004722578.1| cold-shock protein B 1091500001977 PE family; Region: PE; pfam00934 1091500001978 potential frameshift: common BLAST hit: gi|339630938|ref|YP_004722580.1| acyl-CoA dehydrogenase 1091500001979 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398 1091500001980 FIST N domain; Region: FIST; pfam08495 1091500001981 FIST C domain; Region: FIST_C; pfam10442 1091500001982 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 1091500001983 H+ Antiporter protein; Region: 2A0121; TIGR00900 1091500001984 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 1091500001985 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1091500001986 PPE family; Region: PPE; pfam00823 1091500001987 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1091500001988 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1091500001989 Protein of unknown function (DUF2530); Region: DUF2530; pfam10745 1091500001990 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1091500001991 MarR family; Region: MarR; pfam01047 1091500001992 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1091500001993 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1091500001994 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1091500001995 Protein of unknown function (DUF2537); Region: DUF2537; pfam10801 1091500001996 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 1091500001997 phosphoserine aminotransferase, putative; Region: serC_3; TIGR01366 1091500001998 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1091500001999 catalytic residue [active] 1091500002000 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 1091500002001 Ferredoxin [Energy production and conversion]; Region: COG1146 1091500002002 4Fe-4S binding domain; Region: Fer4; pfam00037 1091500002003 ferredoxin-NADP+ reductase; Region: PLN02852 1091500002004 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1091500002005 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 1091500002006 putative dimer interface [polypeptide binding]; other site 1091500002007 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1091500002008 potential frameshift: common BLAST hit: gi|339630954|ref|YP_004722596.1| citrate synthase 1091500002009 potential frameshift: common BLAST hit: gi|224989284|ref|YP_002643971.1| transcriptional regulatory protein 1091500002010 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1091500002011 cyclase homology domain; Region: CHD; cd07302 1091500002012 nucleotidyl binding site; other site 1091500002013 metal binding site [ion binding]; metal-binding site 1091500002014 dimer interface [polypeptide binding]; other site 1091500002015 potential frameshift: common BLAST hit: gi|340625903|ref|YP_004744355.1| putative monooxygenase 1091500002016 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1091500002017 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1091500002018 AAA ATPase domain; Region: AAA_16; pfam13191 1091500002019 Predicted ATPase [General function prediction only]; Region: COG3903 1091500002020 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1091500002021 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1091500002022 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1091500002023 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1091500002024 dimer interface [polypeptide binding]; other site 1091500002025 active site 1091500002026 citrylCoA binding site [chemical binding]; other site 1091500002027 NADH binding [chemical binding]; other site 1091500002028 cationic pore residues; other site 1091500002029 oxalacetate/citrate binding site [chemical binding]; other site 1091500002030 coenzyme A binding site [chemical binding]; other site 1091500002031 catalytic triad [active] 1091500002032 potential frameshift: common BLAST hit: gi|339630962|ref|YP_004722604.1| oxidoreductase 1091500002033 Protein of unknown function (DUF2630); Region: DUF2630; pfam10944 1091500002034 BON domain; Region: BON; pfam04972 1091500002035 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1091500002036 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1091500002037 ligand binding site [chemical binding]; other site 1091500002038 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1091500002039 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1091500002040 dimerization interface [polypeptide binding]; other site 1091500002041 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1091500002042 dimer interface [polypeptide binding]; other site 1091500002043 phosphorylation site [posttranslational modification] 1091500002044 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1091500002045 Mg2+ binding site [ion binding]; other site 1091500002046 G-X-G motif; other site 1091500002047 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1091500002048 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091500002049 active site 1091500002050 phosphorylation site [posttranslational modification] 1091500002051 intermolecular recognition site; other site 1091500002052 dimerization interface [polypeptide binding]; other site 1091500002053 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1091500002054 DNA binding site [nucleotide binding] 1091500002055 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 1091500002056 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; COG0825 1091500002057 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1091500002058 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1091500002059 substrate binding site [chemical binding]; other site 1091500002060 oxyanion hole (OAH) forming residues; other site 1091500002061 trimer interface [polypeptide binding]; other site 1091500002062 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1091500002063 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1091500002064 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1091500002065 Beta-lactamase; Region: Beta-lactamase; pfam00144 1091500002066 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 1091500002067 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1091500002068 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1091500002069 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1091500002070 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 1091500002071 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1091500002072 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1091500002073 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1091500002074 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1091500002075 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 1091500002076 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 1091500002077 potential frameshift: common BLAST hit: gi|339630977|ref|YP_004722619.1| keto acyl-CoA thiolase 1091500002078 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1091500002079 PPE family; Region: PPE; pfam00823 1091500002080 PE family; Region: PE; pfam00934 1091500002081 potential frameshift: common BLAST hit: gi|339630980|ref|YP_004722622.1| glycine/betaine ABC transporter 1091500002082 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 1091500002083 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1091500002084 Coenzyme A binding pocket [chemical binding]; other site 1091500002085 potential frameshift: common BLAST hit: gi|224989314|ref|YP_002644001.1| transposase 1091500002086 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 1091500002087 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 1091500002088 catalytic residues [active] 1091500002089 catalytic nucleophile [active] 1091500002090 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1091500002091 Probable transposase; Region: OrfB_IS605; pfam01385 1091500002092 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1091500002093 dimerization interface [polypeptide binding]; other site 1091500002094 putative catalytic residue [active] 1091500002095 Phage-related replication protein [General function prediction only]; Region: COG4195 1091500002096 manganese transport protein MntH; Reviewed; Region: PRK00701 1091500002097 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1091500002098 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1091500002099 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1091500002100 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1091500002101 short chain dehydrogenase; Provisional; Region: PRK07814 1091500002102 classical (c) SDRs; Region: SDR_c; cd05233 1091500002103 NAD(P) binding site [chemical binding]; other site 1091500002104 active site 1091500002105 potential frameshift: common BLAST hit: gi|15840351|ref|NP_335388.1| phosphate ABC transporter substrate-binding protein 1091500002106 potential frameshift: common BLAST hit: gi|340625938|ref|YP_004744390.1| phosphate-transport integral membrane ABC transporter PSTC2 1091500002107 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1091500002108 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1091500002109 dimer interface [polypeptide binding]; other site 1091500002110 conserved gate region; other site 1091500002111 putative PBP binding loops; other site 1091500002112 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1091500002113 ABC-ATPase subunit interface; other site 1091500002114 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1091500002115 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1091500002116 active site 1091500002117 ATP binding site [chemical binding]; other site 1091500002118 substrate binding site [chemical binding]; other site 1091500002119 activation loop (A-loop); other site 1091500002120 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1091500002121 NHL repeat; Region: NHL; pfam01436 1091500002122 NHL repeat; Region: NHL; pfam01436 1091500002123 NHL repeat; Region: NHL; pfam01436 1091500002124 NHL repeat; Region: NHL; pfam01436 1091500002125 NHL repeat; Region: NHL; pfam01436 1091500002126 PBP superfamily domain; Region: PBP_like_2; cl17296 1091500002127 potential frameshift: common BLAST hit: gi|340625942|ref|YP_004744394.1| phosphate-transport ATP-binding protein ABC transporter PSTB 1091500002128 phosphate ABC transporter, phosphate-binding protein; Region: 3a0107s03; TIGR00975 1091500002129 potential frameshift: common BLAST hit: gi|339630997|ref|YP_004722639.1| phosphate ABC transporter 1091500002130 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1091500002131 dimer interface [polypeptide binding]; other site 1091500002132 conserved gate region; other site 1091500002133 ABC-ATPase subunit interface; other site 1091500002134 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 1091500002135 putative DNA binding site [nucleotide binding]; other site 1091500002136 putative homodimer interface [polypeptide binding]; other site 1091500002137 potential frameshift: common BLAST hit: gi|339631000|ref|YP_004722642.1| ATP dependent DNA ligase 1091500002138 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1091500002139 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1091500002140 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1091500002141 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1091500002142 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1091500002143 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1091500002144 anti sigma factor interaction site; other site 1091500002145 regulatory phosphorylation site [posttranslational modification]; other site 1091500002146 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1091500002147 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1091500002148 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1091500002149 short chain dehydrogenase; Provisional; Region: PRK08251 1091500002150 classical (c) SDR, subgroup 6; Region: SDR_c6; cd05350 1091500002151 putative NAD(P) binding site [chemical binding]; other site 1091500002152 active site 1091500002153 potential frameshift: common BLAST hit: gi|340625959|ref|YP_004744411.1| putative glucose-6-phosphate isomerase PGI 1091500002154 Predicted esterase [General function prediction only]; Region: COG0627 1091500002155 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 1091500002156 hypothetical protein; Provisional; Region: PRK07857 1091500002157 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1091500002158 Part of AAA domain; Region: AAA_19; pfam13245 1091500002159 Family description; Region: UvrD_C_2; pfam13538 1091500002160 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1091500002161 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1091500002162 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1091500002163 CoA-ligase; Region: Ligase_CoA; pfam00549 1091500002164 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1091500002165 CoA binding domain; Region: CoA_binding; smart00881 1091500002166 CoA-ligase; Region: Ligase_CoA; pfam00549 1091500002167 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1091500002168 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1091500002169 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1091500002170 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1091500002171 active site 1091500002172 substrate binding site [chemical binding]; other site 1091500002173 cosubstrate binding site; other site 1091500002174 catalytic site [active] 1091500002175 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1091500002176 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1091500002177 purine monophosphate binding site [chemical binding]; other site 1091500002178 dimer interface [polypeptide binding]; other site 1091500002179 putative catalytic residues [active] 1091500002180 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1091500002181 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1091500002182 potential frameshift: common BLAST hit: gi|339631020|ref|YP_004722662.1| magnesium chelatase 1091500002183 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 1091500002184 homotetrameric interface [polypeptide binding]; other site 1091500002185 putative active site [active] 1091500002186 metal binding site [ion binding]; metal-binding site 1091500002187 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 1091500002188 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1091500002189 Thermus thermophilus CsoR, a Cu(I)-sensing transcriptional regulator, and related domains; this domain family was previously known as part of DUF156; Region: TthCsoR-like_DUF156; cd10151 1091500002190 putative homodimer interface [polypeptide binding]; other site 1091500002191 putative homotetramer interface [polypeptide binding]; other site 1091500002192 allosteric switch controlling residues; other site 1091500002193 putative metal binding site [ion binding]; other site 1091500002194 putative homodimer-homodimer interface [polypeptide binding]; other site 1091500002195 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 1091500002196 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 1091500002197 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1091500002198 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1091500002199 potential frameshift: common BLAST hit: gi|224989367|ref|YP_002644054.1| integral membrane protein 1091500002200 enoyl-CoA hydratase; Provisional; Region: PRK07827 1091500002201 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1091500002202 substrate binding site [chemical binding]; other site 1091500002203 oxyanion hole (OAH) forming residues; other site 1091500002204 trimer interface [polypeptide binding]; other site 1091500002205 potential frameshift: common BLAST hit: gi|339631034|ref|YP_004722676.1| acyl-CoA dehydrogenase 1091500002206 potential frameshift: common BLAST hit: gi|339631035|ref|YP_004722677.1| propionyl-CoA carboxylase subunit alpha 1091500002207 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1091500002208 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1091500002209 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1091500002210 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1091500002211 active site 1091500002212 potential frameshift: common BLAST hit: gi|148660757|ref|YP_001282280.1| PE-PGRS family protein 1091500002213 PE family; Region: PE; pfam00934 1091500002214 PE family; Region: PE; pfam00934 1091500002215 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1091500002216 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1091500002217 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1091500002218 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1091500002219 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1091500002220 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091500002221 active site 1091500002222 phosphorylation site [posttranslational modification] 1091500002223 intermolecular recognition site; other site 1091500002224 dimerization interface [polypeptide binding]; other site 1091500002225 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1091500002226 DNA binding site [nucleotide binding] 1091500002227 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1091500002228 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1091500002229 dimerization interface [polypeptide binding]; other site 1091500002230 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1091500002231 dimer interface [polypeptide binding]; other site 1091500002232 phosphorylation site [posttranslational modification] 1091500002233 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1091500002234 ATP binding site [chemical binding]; other site 1091500002235 Mg2+ binding site [ion binding]; other site 1091500002236 G-X-G motif; other site 1091500002237 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 1091500002238 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1091500002239 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1091500002240 MPT binding site; other site 1091500002241 trimer interface [polypeptide binding]; other site 1091500002242 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1091500002243 Large-conductance mechanosensitive channel, MscL; Region: MscL; pfam01741 1091500002244 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1091500002245 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1091500002246 Walker A/P-loop; other site 1091500002247 ATP binding site [chemical binding]; other site 1091500002248 Q-loop/lid; other site 1091500002249 ABC transporter signature motif; other site 1091500002250 Walker B; other site 1091500002251 D-loop; other site 1091500002252 H-loop/switch region; other site 1091500002253 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1091500002254 FtsX-like permease family; Region: FtsX; pfam02687 1091500002255 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1091500002256 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1091500002257 FtsX-like permease family; Region: FtsX; pfam02687 1091500002258 Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101 1091500002259 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1091500002260 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1091500002261 substrate binding pocket [chemical binding]; other site 1091500002262 chain length determination region; other site 1091500002263 substrate-Mg2+ binding site; other site 1091500002264 catalytic residues [active] 1091500002265 aspartate-rich region 1; other site 1091500002266 active site lid residues [active] 1091500002267 aspartate-rich region 2; other site 1091500002268 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1091500002269 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2331 1091500002270 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 1091500002271 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1091500002272 UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210 1091500002273 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1091500002274 active site 1091500002275 potential frameshift: common BLAST hit: gi|253799978|ref|YP_003032979.1| molybdopterin biosynthesis protein moeA1 1091500002276 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1091500002277 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1091500002278 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091500002279 S-adenosylmethionine binding site [chemical binding]; other site 1091500002280 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1091500002281 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1091500002282 ligand binding site [chemical binding]; other site 1091500002283 flexible hinge region; other site 1091500002284 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1091500002285 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1091500002286 Coenzyme A binding pocket [chemical binding]; other site 1091500002287 Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145 1091500002288 arginine deiminase; Provisional; Region: PRK01388 1091500002289 Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928 1091500002290 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1091500002291 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 1091500002292 aminodeoxychorismate synthase, component I, clade 2; Region: PabB-clade2; TIGR01824 1091500002293 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 1091500002294 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1091500002295 active site 1091500002296 HIGH motif; other site 1091500002297 KMSKS motif; other site 1091500002298 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1091500002299 tRNA binding surface [nucleotide binding]; other site 1091500002300 anticodon binding site; other site 1091500002301 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1091500002302 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1091500002303 active site 1091500002304 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 1091500002305 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1091500002306 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1091500002307 G5 domain; Region: G5; pfam07501 1091500002308 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1091500002309 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1091500002310 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091500002311 S-adenosylmethionine binding site [chemical binding]; other site 1091500002312 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 1091500002313 Increased loss of mitochondrial DNA protein 1; Region: Ilm1; pfam10311 1091500002314 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1091500002315 potential frameshift: common BLAST hit: gi|339631074|ref|YP_004722716.1| polyketide synthase 1091500002316 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1091500002317 putative active site [active] 1091500002318 catalytic residue [active] 1091500002319 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1091500002320 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 1091500002321 5S rRNA interface [nucleotide binding]; other site 1091500002322 CTC domain interface [polypeptide binding]; other site 1091500002323 L16 interface [polypeptide binding]; other site 1091500002324 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 1091500002325 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1091500002326 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 1091500002327 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1091500002328 active site 1091500002329 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 1091500002330 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1091500002331 Substrate binding site; other site 1091500002332 Mg++ binding site; other site 1091500002333 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1091500002334 active site 1091500002335 substrate binding site [chemical binding]; other site 1091500002336 CoA binding site [chemical binding]; other site 1091500002337 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1091500002338 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1091500002339 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1091500002340 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1091500002341 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1091500002342 ATP binding site [chemical binding]; other site 1091500002343 putative Mg++ binding site [ion binding]; other site 1091500002344 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1091500002345 nucleotide binding region [chemical binding]; other site 1091500002346 ATP-binding site [chemical binding]; other site 1091500002347 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1091500002348 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334 1091500002349 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1091500002350 homodimer interface [polypeptide binding]; other site 1091500002351 metal binding site [ion binding]; metal-binding site 1091500002352 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 1091500002353 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 1091500002354 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1091500002355 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1091500002356 enolase; Provisional; Region: eno; PRK00077 1091500002357 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1091500002358 dimer interface [polypeptide binding]; other site 1091500002359 metal binding site [ion binding]; metal-binding site 1091500002360 substrate binding pocket [chemical binding]; other site 1091500002361 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1091500002362 Septum formation initiator; Region: DivIC; pfam04977 1091500002363 Uncharacterized conserved protein [Function unknown]; Region: COG1507 1091500002364 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1091500002365 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1091500002366 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 1091500002367 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091500002368 active site 1091500002369 phosphorylation site [posttranslational modification] 1091500002370 intermolecular recognition site; other site 1091500002371 dimerization interface [polypeptide binding]; other site 1091500002372 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1091500002373 DNA binding site [nucleotide binding] 1091500002374 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 1091500002375 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1091500002376 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1091500002377 Ligand Binding Site [chemical binding]; other site 1091500002378 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1091500002379 dimer interface [polypeptide binding]; other site 1091500002380 phosphorylation site [posttranslational modification] 1091500002381 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1091500002382 ATP binding site [chemical binding]; other site 1091500002383 Mg2+ binding site [ion binding]; other site 1091500002384 G-X-G motif; other site 1091500002385 potential frameshift: common BLAST hit: gi|339631091|ref|YP_004722733.1| potassium transporter subunit A 1091500002386 potential frameshift: common BLAST hit: gi|253799939|ref|YP_003032940.1| potassium-transporting ATPase subunit B 1091500002387 potassium-transporting ATPase subunit C; Provisional; Region: PRK14001 1091500002388 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1091500002389 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1091500002390 dimer interface [polypeptide binding]; other site 1091500002391 phosphorylation site [posttranslational modification] 1091500002392 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1091500002393 ATP binding site [chemical binding]; other site 1091500002394 Mg2+ binding site [ion binding]; other site 1091500002395 G-X-G motif; other site 1091500002396 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1091500002397 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091500002398 active site 1091500002399 phosphorylation site [posttranslational modification] 1091500002400 intermolecular recognition site; other site 1091500002401 dimerization interface [polypeptide binding]; other site 1091500002402 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1091500002403 DNA binding site [nucleotide binding] 1091500002404 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 1091500002405 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1091500002406 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 1091500002407 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1091500002408 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1091500002409 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1091500002410 PPE family; Region: PPE; pfam00823 1091500002411 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1091500002412 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1091500002413 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1091500002414 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1091500002415 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1091500002416 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 1091500002417 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1091500002418 MULE transposase domain; Region: MULE; pfam10551 1091500002419 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1091500002420 MarR family; Region: MarR_2; pfam12802 1091500002421 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1091500002422 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1091500002423 NAD(P) binding site [chemical binding]; other site 1091500002424 active site 1091500002425 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 1091500002426 Helix-turn-helix domain; Region: HTH_17; pfam12728 1091500002427 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1091500002428 Domain of unknown function (DUF427); Region: DUF427; cl00998 1091500002429 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 1091500002430 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1091500002431 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1091500002432 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1091500002433 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 1091500002434 dimer interface [polypeptide binding]; other site 1091500002435 acyl-activating enzyme (AAE) consensus motif; other site 1091500002436 putative active site [active] 1091500002437 AMP binding site [chemical binding]; other site 1091500002438 putative CoA binding site [chemical binding]; other site 1091500002439 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1091500002440 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 1091500002441 hydrophobic ligand binding site; other site 1091500002442 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 1091500002443 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1091500002444 putative active site [active] 1091500002445 putative dimer interface [polypeptide binding]; other site 1091500002446 Patatin-like phospholipase; Region: Patatin; pfam01734 1091500002447 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1091500002448 nucleophile elbow; other site 1091500002449 hypothetical protein; Provisional; Region: PRK10279 1091500002450 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 1091500002451 active site 1091500002452 nucleophile elbow; other site 1091500002453 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1091500002454 active site residue [active] 1091500002455 PE family; Region: PE; pfam00934 1091500002456 PE family; Region: PE; pfam00934 1091500002457 Predicted membrane protein [Function unknown]; Region: COG4425 1091500002458 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 1091500002459 enoyl-CoA hydratase; Provisional; Region: PRK05862 1091500002460 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1091500002461 substrate binding site [chemical binding]; other site 1091500002462 oxyanion hole (OAH) forming residues; other site 1091500002463 trimer interface [polypeptide binding]; other site 1091500002464 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 1091500002465 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1091500002466 substrate binding site [chemical binding]; other site 1091500002467 oxyanion hole (OAH) forming residues; other site 1091500002468 trimer interface [polypeptide binding]; other site 1091500002469 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 1091500002470 Predicted membrane protein [Function unknown]; Region: COG4760 1091500002471 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1091500002472 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1091500002473 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 1091500002474 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1091500002475 dimer interface [polypeptide binding]; other site 1091500002476 active site 1091500002477 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 1091500002478 active site 1091500002479 catalytic triad [active] 1091500002480 oxyanion hole [active] 1091500002481 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1091500002482 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1091500002483 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 1091500002484 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1091500002485 dimer interface [polypeptide binding]; other site 1091500002486 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1091500002487 catalytic residue [active] 1091500002488 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 1091500002489 RDD family; Region: RDD; pfam06271 1091500002490 cystathionine gamma-synthase; Provisional; Region: PRK07811 1091500002491 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1091500002492 homodimer interface [polypeptide binding]; other site 1091500002493 substrate-cofactor binding pocket; other site 1091500002494 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1091500002495 catalytic residue [active] 1091500002496 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1091500002497 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1091500002498 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1091500002499 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 1091500002500 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 1091500002501 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1091500002502 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1091500002503 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1091500002504 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1091500002505 catalytic residue [active] 1091500002506 putative FPP diphosphate binding site; other site 1091500002507 putative FPP binding hydrophobic cleft; other site 1091500002508 dimer interface [polypeptide binding]; other site 1091500002509 putative IPP diphosphate binding site; other site 1091500002510 PE family; Region: PE; pfam00934 1091500002511 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1091500002512 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 1091500002513 putative IPP diphosphate binding site; other site 1091500002514 Glycosyl hydrolase family 12; Region: Glyco_hydro_12; pfam01670 1091500002515 PE family; Region: PE; pfam00934 1091500002516 pantothenate kinase; Provisional; Region: PRK05439 1091500002517 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1091500002518 ATP-binding site [chemical binding]; other site 1091500002519 CoA-binding site [chemical binding]; other site 1091500002520 Mg2+-binding site [ion binding]; other site 1091500002521 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1091500002522 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1091500002523 dimer interface [polypeptide binding]; other site 1091500002524 active site 1091500002525 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1091500002526 folate binding site [chemical binding]; other site 1091500002527 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 1091500002528 dinuclear metal binding motif [ion binding]; other site 1091500002529 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 1091500002530 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 1091500002531 putative active site [active] 1091500002532 PhoH-like protein; Region: PhoH; pfam02562 1091500002533 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1091500002534 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1091500002535 NodB motif; other site 1091500002536 active site 1091500002537 catalytic site [active] 1091500002538 metal binding site [ion binding]; metal-binding site 1091500002539 potential frameshift: common BLAST hit: gi|339631164|ref|YP_004722806.1| fumarase 1091500002540 potential frameshift: common BLAST hit: gi|345461998|ref|NP_215615.2| fructose 1,6-bisphosphatase II 1091500002541 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 1091500002542 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1091500002543 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1091500002544 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 1091500002545 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1091500002546 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1091500002547 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1091500002548 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1091500002549 3beta-hydroxysteroid dehydrogenases (3b-HSD)-like, extended (e) SDRs; Region: 3b-HSD-like_SDR_e; cd05241 1091500002550 3-beta hydroxysteroid dehydrogenase/isomerase family; Region: 3Beta_HSD; pfam01073 1091500002551 putative NAD(P) binding site [chemical binding]; other site 1091500002552 active site 1091500002553 putative substrate binding site [chemical binding]; other site 1091500002554 exodeoxyribonuclease VII, small subunit; Region: xseB; TIGR01280 1091500002555 Exonuclease VII, large subunit [DNA replication, recombination, and repair]; Region: XseA; COG1570 1091500002556 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1091500002557 generic binding surface II; other site 1091500002558 generic binding surface I; other site 1091500002559 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1091500002560 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1091500002561 Yip1 domain; Region: Yip1; pfam04893 1091500002562 GTP-binding protein YchF; Reviewed; Region: PRK09601 1091500002563 YchF GTPase; Region: YchF; cd01900 1091500002564 G1 box; other site 1091500002565 GTP/Mg2+ binding site [chemical binding]; other site 1091500002566 Switch I region; other site 1091500002567 G2 box; other site 1091500002568 Switch II region; other site 1091500002569 G3 box; other site 1091500002570 G4 box; other site 1091500002571 G5 box; other site 1091500002572 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1091500002573 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 1091500002574 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: VapC; COG1487 1091500002575 putative active site [active] 1091500002576 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1091500002577 cyclase homology domain; Region: CHD; cd07302 1091500002578 nucleotidyl binding site; other site 1091500002579 metal binding site [ion binding]; metal-binding site 1091500002580 dimer interface [polypeptide binding]; other site 1091500002581 glucose-6-phosphate 1-dehydrogenase; Region: zwf; TIGR00871 1091500002582 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1091500002583 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1091500002584 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1091500002585 6-phosphogluconate dehydrogenase (decarboxylating); Region: gnd_rel; TIGR00872 1091500002586 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1091500002587 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1091500002588 pyruvate phosphate dikinase; Provisional; Region: PRK05878 1091500002589 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1091500002590 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700 1091500002591 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1091500002592 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1091500002593 non-specific DNA binding site [nucleotide binding]; other site 1091500002594 salt bridge; other site 1091500002595 sequence-specific DNA binding site [nucleotide binding]; other site 1091500002596 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 1091500002597 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1091500002598 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 1091500002599 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 1091500002600 citrate synthase; Provisional; Region: PRK14033 1091500002601 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 1091500002602 oxalacetate binding site [chemical binding]; other site 1091500002603 citrylCoA binding site [chemical binding]; other site 1091500002604 coenzyme A binding site [chemical binding]; other site 1091500002605 catalytic triad [active] 1091500002606 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1091500002607 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1091500002608 THF binding site; other site 1091500002609 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1091500002610 substrate binding site [chemical binding]; other site 1091500002611 THF binding site; other site 1091500002612 zinc-binding site [ion binding]; other site 1091500002613 potential frameshift: common BLAST hit: gi|224989540|ref|YP_002644227.1| PPE family protein 1091500002614 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1091500002615 active site 1091500002616 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1091500002617 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1091500002618 substrate binding site [chemical binding]; other site 1091500002619 oxyanion hole (OAH) forming residues; other site 1091500002620 enoyl-CoA hydratase; Provisional; Region: PRK06494 1091500002621 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 1091500002622 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 1091500002623 potential frameshift: common BLAST hit: gi|224989546|ref|YP_002644233.1| integral membrane protein 1091500002624 enoyl-CoA hydratase; Provisional; Region: PRK06688 1091500002625 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 1091500002626 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1091500002627 trimer interface [polypeptide binding]; other site 1091500002628 potential frameshift: common BLAST hit: gi|340626157|ref|YP_004744609.1| putative enoyl-CoA hydratase ECHA10 1091500002629 potential frameshift: common BLAST hit: gi|339631208|ref|YP_004722850.1| alpha-methylacyl-CoA racemase 1091500002630 potential frameshift: common BLAST hit: gi|339631208|ref|YP_004722850.1| alpha-methylacyl-CoA racemase 1091500002631 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 1091500002632 NAD binding site [chemical binding]; other site 1091500002633 homodimer interface [polypeptide binding]; other site 1091500002634 homotetramer interface [polypeptide binding]; other site 1091500002635 active site 1091500002636 potential frameshift: common BLAST hit: gi|339631210|ref|YP_004722852.1| transporter 1091500002637 potential frameshift: common BLAST hit: gi|224989551|ref|YP_002644238.1| transmembrane transport protein 1091500002638 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1091500002639 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1091500002640 active site 1091500002641 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1091500002642 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1091500002643 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1091500002644 potential frameshift: common BLAST hit: gi|253799806|ref|YP_003032807.1| NAD-dependent deacetylase 1091500002645 Predicted transcriptional regulators [Transcription]; Region: COG1725 1091500002646 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1091500002647 DNA-binding site [nucleotide binding]; DNA binding site 1091500002648 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1091500002649 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 1091500002650 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797 1091500002651 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1091500002652 uncharacterized HhH-GPD family protein; Region: TIGR03252 1091500002653 minor groove reading motif; other site 1091500002654 helix-hairpin-helix signature motif; other site 1091500002655 potential frameshift: common BLAST hit: gi|253799798|ref|YP_003032799.1| mannosyltransferase 1091500002656 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 1091500002657 aromatic arch; other site 1091500002658 DCoH dimer interaction site [polypeptide binding]; other site 1091500002659 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 1091500002660 DCoH tetramer interaction site [polypeptide binding]; other site 1091500002661 substrate binding site [chemical binding]; other site 1091500002662 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1091500002663 active site 1091500002664 8-oxo-dGMP binding site [chemical binding]; other site 1091500002665 nudix motif; other site 1091500002666 metal binding site [ion binding]; metal-binding site 1091500002667 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 1091500002668 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1091500002669 [4Fe-4S] binding site [ion binding]; other site 1091500002670 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1091500002671 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1091500002672 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1091500002673 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1091500002674 molybdopterin cofactor binding site; other site 1091500002675 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 1091500002676 nitrate reductase molybdenum cofactor assembly chaperone; Region: narJ; TIGR00684 1091500002677 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 1091500002678 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1091500002679 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1091500002680 G1 box; other site 1091500002681 putative GEF interaction site [polypeptide binding]; other site 1091500002682 GTP/Mg2+ binding site [chemical binding]; other site 1091500002683 Switch I region; other site 1091500002684 G2 box; other site 1091500002685 G3 box; other site 1091500002686 Switch II region; other site 1091500002687 G4 box; other site 1091500002688 G5 box; other site 1091500002689 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1091500002690 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1091500002691 potential frameshift: common BLAST hit: gi|340626180|ref|YP_004744632.1| putative lipoprotein LPQW 1091500002692 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1091500002693 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1091500002694 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1091500002695 PPE family; Region: PPE; pfam00823 1091500002696 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1091500002697 PE family; Region: PE; pfam00934 1091500002698 N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D- glucopyranoside deacetylase; Region: mycothiol_MshB; TIGR03445 1091500002699 PE family; Region: PE; pfam00934 1091500002700 FO synthase; Reviewed; Region: fbiC; PRK09234 1091500002701 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1091500002702 FeS/SAM binding site; other site 1091500002703 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1091500002704 FeS/SAM binding site; other site 1091500002705 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 1091500002706 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1091500002707 active site 1091500002708 FMN binding site [chemical binding]; other site 1091500002709 2,4-decadienoyl-CoA binding site; other site 1091500002710 catalytic residue [active] 1091500002711 4Fe-4S cluster binding site [ion binding]; other site 1091500002712 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1091500002713 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1091500002714 Predicted transcriptional regulators [Transcription]; Region: COG1695 1091500002715 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1091500002716 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 1091500002717 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 1091500002718 4Fe-4S binding domain; Region: Fer4; pfam00037 1091500002719 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 1091500002720 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1091500002721 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1091500002722 homodimer interface [polypeptide binding]; other site 1091500002723 catalytic residue [active] 1091500002724 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1091500002725 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 1091500002726 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1091500002727 ATP binding site [chemical binding]; other site 1091500002728 putative Mg++ binding site [ion binding]; other site 1091500002729 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1091500002730 ATP-binding site [chemical binding]; other site 1091500002731 potential frameshift: common BLAST hit: gi|253799776|ref|YP_003032777.1| polyketide beta-ketoacyl synthase 1091500002732 potential frameshift: common BLAST hit: gi|339631248|ref|YP_004722890.1| polyketide beta-ketoacyl synthase 1091500002733 potential frameshift: common BLAST hit: gi|224989585|ref|YP_002644272.1| polyketide beta-ketoacyl synthase 1091500002734 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1091500002735 potential frameshift: common BLAST hit: gi|339631250|ref|YP_004722892.1| transporter 1091500002736 PE-PPE domain; Region: PE-PPE; pfam08237 1091500002737 acyl-CoA synthetase; Validated; Region: PRK05850 1091500002738 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1091500002739 acyl-activating enzyme (AAE) consensus motif; other site 1091500002740 active site 1091500002741 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1091500002742 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1091500002743 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 1091500002744 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1091500002745 NAD(P) binding site [chemical binding]; other site 1091500002746 catalytic residues [active] 1091500002747 Proline dehydrogenase; Region: Pro_dh; pfam01619 1091500002748 potential frameshift: common BLAST hit: gi|339631256|ref|YP_004722898.1| alternative RNA polymerase sigma factor SIGI 1091500002749 haloalkane dehalogenase; Provisional; Region: PRK03204 1091500002750 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1091500002751 catalytic site [active] 1091500002752 potential frameshift: common BLAST hit: gi|15840634|ref|NP_335671.1| alpha/beta hydrolase 1091500002753 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1091500002754 PGAP1-like protein; Region: PGAP1; pfam07819 1091500002755 acyl-CoA synthetase; Validated; Region: PRK07787 1091500002756 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1091500002757 acyl-activating enzyme (AAE) consensus motif; other site 1091500002758 AMP binding site [chemical binding]; other site 1091500002759 active site 1091500002760 CoA binding site [chemical binding]; other site 1091500002761 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1091500002762 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1091500002763 PE family; Region: PE; pfam00934 1091500002764 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1091500002765 PPE family; Region: PPE; pfam00823 1091500002766 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1091500002767 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1091500002768 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1091500002769 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1091500002770 MULE transposase domain; Region: MULE; pfam10551 1091500002771 metabolite-proton symporter; Region: 2A0106; TIGR00883 1091500002772 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 1091500002773 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 1091500002774 putative trimer interface [polypeptide binding]; other site 1091500002775 putative CoA binding site [chemical binding]; other site 1091500002776 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 1091500002777 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 1091500002778 metal binding site [ion binding]; metal-binding site 1091500002779 putative dimer interface [polypeptide binding]; other site 1091500002780 TIGR00730 family protein; Region: TIGR00730 1091500002781 long-chain-acyl-CoA synthetase; Validated; Region: PRK08279 1091500002782 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 1091500002783 acyl-activating enzyme (AAE) consensus motif; other site 1091500002784 putative AMP binding site [chemical binding]; other site 1091500002785 putative active site [active] 1091500002786 putative CoA binding site [chemical binding]; other site 1091500002787 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1091500002788 dihydropteroate synthase; Region: DHPS; TIGR01496 1091500002789 substrate binding pocket [chemical binding]; other site 1091500002790 dimer interface [polypeptide binding]; other site 1091500002791 inhibitor binding site; inhibition site 1091500002792 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 1091500002793 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1091500002794 DivIVA domain; Region: DivI1A_domain; TIGR03544 1091500002795 DNA-3-methyladenine glycosylase I; Region: tag; TIGR00624 1091500002796 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 1091500002797 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 1091500002798 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1091500002799 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 1091500002800 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1091500002801 ligand binding site; other site 1091500002802 oligomer interface; other site 1091500002803 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1091500002804 dimer interface [polypeptide binding]; other site 1091500002805 N-terminal domain interface [polypeptide binding]; other site 1091500002806 sulfate 1 binding site; other site 1091500002807 potential frameshift: common BLAST hit: gi|340626227|ref|YP_004744679.1| PE family protein 1091500002808 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 1091500002809 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 1091500002810 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1091500002811 potential frameshift: common BLAST hit: gi|339631284|ref|YP_004722926.1| tetronasin ABC transporter substrate-binding protein 1091500002812 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1091500002813 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1091500002814 Walker A/P-loop; other site 1091500002815 ATP binding site [chemical binding]; other site 1091500002816 Q-loop/lid; other site 1091500002817 ABC transporter signature motif; other site 1091500002818 Walker B; other site 1091500002819 D-loop; other site 1091500002820 H-loop/switch region; other site 1091500002821 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1091500002822 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1091500002823 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1091500002824 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091500002825 S-adenosylmethionine binding site [chemical binding]; other site 1091500002826 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647 1091500002827 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1091500002828 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1091500002829 DNA binding residues [nucleotide binding] 1091500002830 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1091500002831 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1091500002832 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1091500002833 protein binding site [polypeptide binding]; other site 1091500002834 sec-independent translocase; Provisional; Region: PRK03100 1091500002835 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1091500002836 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1091500002837 active site 1091500002838 motif I; other site 1091500002839 motif II; other site 1091500002840 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1091500002841 Predicted membrane protein [Function unknown]; Region: COG3428 1091500002842 Bacterial PH domain; Region: DUF304; pfam03703 1091500002843 Uncharacterized conserved protein [Function unknown]; Region: COG3402 1091500002844 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 1091500002845 Domain of unknown function DUF59; Region: DUF59; cl00941 1091500002846 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1091500002847 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1091500002848 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 1091500002849 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1091500002850 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1091500002851 catalytic residue [active] 1091500002852 Predicted membrane protein [Function unknown]; Region: COG4420 1091500002853 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1091500002854 MgtE intracellular N domain; Region: MgtE_N; smart00924 1091500002855 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1091500002856 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 1091500002857 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1091500002858 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1091500002859 potential frameshift: common BLAST hit: gi|340626249|ref|YP_004744701.1| putative sugar-transport integral membrane protein ABC transporter 1091500002860 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1091500002861 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1091500002862 dimer interface [polypeptide binding]; other site 1091500002863 conserved gate region; other site 1091500002864 ABC-ATPase subunit interface; other site 1091500002865 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1091500002866 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1091500002867 Walker A/P-loop; other site 1091500002868 ATP binding site [chemical binding]; other site 1091500002869 Q-loop/lid; other site 1091500002870 ABC transporter signature motif; other site 1091500002871 Walker B; other site 1091500002872 D-loop; other site 1091500002873 H-loop/switch region; other site 1091500002874 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1091500002875 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 1091500002876 oligomer interface [polypeptide binding]; other site 1091500002877 metal binding site [ion binding]; metal-binding site 1091500002878 metal binding site [ion binding]; metal-binding site 1091500002879 putative Cl binding site [ion binding]; other site 1091500002880 basic sphincter; other site 1091500002881 hydrophobic gate; other site 1091500002882 periplasmic entrance; other site 1091500002883 malate dehydrogenase; Provisional; Region: PRK05442 1091500002884 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 1091500002885 NAD(P) binding site [chemical binding]; other site 1091500002886 dimer interface [polypeptide binding]; other site 1091500002887 malate binding site [chemical binding]; other site 1091500002888 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 1091500002889 potential frameshift: common BLAST hit: gi|339631310|ref|YP_004722952.1| PE-PGRS family protein 1091500002890 potential frameshift: common BLAST hit: gi|339631310|ref|YP_004722952.1| PE-PGRS family protein 1091500002891 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1091500002892 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1091500002893 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1091500002894 NAD(P) binding site [chemical binding]; other site 1091500002895 active site 1091500002896 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 1091500002897 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 1091500002898 potential frameshift: common BLAST hit: gi|161352467|ref|NP_215764.2| alpha-ketoglutarate decarboxylase 1091500002899 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1091500002900 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 1091500002901 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 1091500002902 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1091500002903 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1091500002904 ATP binding site [chemical binding]; other site 1091500002905 Mg++ binding site [ion binding]; other site 1091500002906 motif III; other site 1091500002907 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1091500002908 nucleotide binding region [chemical binding]; other site 1091500002909 ATP-binding site [chemical binding]; other site 1091500002910 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 1091500002911 putative RNA binding site [nucleotide binding]; other site 1091500002912 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1091500002913 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1091500002914 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1091500002915 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1091500002916 FAD binding domain; Region: FAD_binding_4; pfam01565 1091500002917 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 1091500002918 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1091500002919 H+ Antiporter protein; Region: 2A0121; TIGR00900 1091500002920 putative substrate translocation pore; other site 1091500002921 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 1091500002922 Fe-S cluster binding site [ion binding]; other site 1091500002923 DNA binding site [nucleotide binding] 1091500002924 active site 1091500002925 hypothetical protein; Validated; Region: PRK05868 1091500002926 hypothetical protein; Provisional; Region: PRK07236 1091500002927 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1091500002928 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1091500002929 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1091500002930 HIT family signature motif; other site 1091500002931 catalytic residue [active] 1091500002932 amidase; Provisional; Region: PRK12470 1091500002933 Amidase; Region: Amidase; pfam01425 1091500002934 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1091500002935 cyclase homology domain; Region: CHD; cd07302 1091500002936 nucleotidyl binding site; other site 1091500002937 metal binding site [ion binding]; metal-binding site 1091500002938 dimer interface [polypeptide binding]; other site 1091500002939 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1091500002940 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1091500002941 active site 1091500002942 ATP binding site [chemical binding]; other site 1091500002943 substrate binding site [chemical binding]; other site 1091500002944 activation loop (A-loop); other site 1091500002945 PknH-like extracellular domain; Region: PknH_C; pfam14032 1091500002946 potential frameshift: common BLAST hit: gi|340626282|ref|YP_004744734.1| putative transcriptional regulatory protein EMBR 1091500002947 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 1091500002948 putative active site [active] 1091500002949 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 1091500002950 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 1091500002951 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1091500002952 potential frameshift: common BLAST hit: gi|340626287|ref|YP_004744739.1| putative drugs-transport transmembrane ATP-binding protein ABC 1091500002953 potential frameshift: common BLAST hit: gi|253799682|ref|YP_003032683.1| drugs-transport transmembrane ATP-binding protein ABC transporter 1091500002954 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 1091500002955 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 1091500002956 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1091500002957 catalytic core [active] 1091500002958 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1091500002959 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1091500002960 active site 1091500002961 metal binding site [ion binding]; metal-binding site 1091500002962 DNA binding site [nucleotide binding] 1091500002963 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1091500002964 Walker A/P-loop; other site 1091500002965 ATP binding site [chemical binding]; other site 1091500002966 potential frameshift: common BLAST hit: gi|339631347|ref|YP_004722989.1| dehydrogenase FAD flavoprotein GMC oxidoreductase 1091500002967 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1091500002968 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 1091500002969 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 1091500002970 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1091500002971 Walker A/P-loop; other site 1091500002972 ATP binding site [chemical binding]; other site 1091500002973 Q-loop/lid; other site 1091500002974 ABC transporter signature motif; other site 1091500002975 Walker B; other site 1091500002976 D-loop; other site 1091500002977 H-loop/switch region; other site 1091500002978 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1091500002979 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1091500002980 Walker A/P-loop; other site 1091500002981 ATP binding site [chemical binding]; other site 1091500002982 Q-loop/lid; other site 1091500002983 ABC transporter signature motif; other site 1091500002984 Walker B; other site 1091500002985 D-loop; other site 1091500002986 H-loop/switch region; other site 1091500002987 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1091500002988 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1091500002989 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1091500002990 dimer interface [polypeptide binding]; other site 1091500002991 conserved gate region; other site 1091500002992 putative PBP binding loops; other site 1091500002993 ABC-ATPase subunit interface; other site 1091500002994 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 1091500002995 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1091500002996 dimer interface [polypeptide binding]; other site 1091500002997 conserved gate region; other site 1091500002998 putative PBP binding loops; other site 1091500002999 ABC-ATPase subunit interface; other site 1091500003000 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 1091500003001 active site clefts [active] 1091500003002 zinc binding site [ion binding]; other site 1091500003003 dimer interface [polypeptide binding]; other site 1091500003004 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1091500003005 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1091500003006 Active Sites [active] 1091500003007 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 1091500003008 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1091500003009 CysD dimerization site [polypeptide binding]; other site 1091500003010 G1 box; other site 1091500003011 putative GEF interaction site [polypeptide binding]; other site 1091500003012 GTP/Mg2+ binding site [chemical binding]; other site 1091500003013 Switch I region; other site 1091500003014 G2 box; other site 1091500003015 G3 box; other site 1091500003016 Switch II region; other site 1091500003017 G4 box; other site 1091500003018 G5 box; other site 1091500003019 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1091500003020 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 1091500003021 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1091500003022 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1091500003023 Walker A/P-loop; other site 1091500003024 ligand-binding site [chemical binding]; other site 1091500003025 ATP binding site [chemical binding]; other site 1091500003026 Rrf2 family protein; Region: rrf2_super; TIGR00738 1091500003027 Transcriptional regulator; Region: Rrf2; pfam02082 1091500003028 Predicted membrane protein [Function unknown]; Region: COG4325 1091500003029 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 1091500003030 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1091500003031 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 1091500003032 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1091500003033 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1091500003034 active site 1091500003035 HIGH motif; other site 1091500003036 KMSK motif region; other site 1091500003037 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1091500003038 tRNA binding surface [nucleotide binding]; other site 1091500003039 anticodon binding site; other site 1091500003040 potential frameshift: common BLAST hit: gi|340626309|ref|YP_004744761.1| putative diaminopimelate decarboxylase LYSA 1091500003041 homoserine dehydrogenase; Provisional; Region: PRK06349 1091500003042 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1091500003043 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1091500003044 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1091500003045 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1091500003046 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 1091500003047 homodimer interface [polypeptide binding]; other site 1091500003048 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1091500003049 catalytic residue [active] 1091500003050 Homoserine kinase [Amino acid transport and metabolism]; Region: ThrB; COG0083 1091500003051 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1091500003052 transcription termination factor Rho; Provisional; Region: PRK12608 1091500003053 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1091500003054 RNA binding site [nucleotide binding]; other site 1091500003055 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1091500003056 multimer interface [polypeptide binding]; other site 1091500003057 Walker A motif; other site 1091500003058 ATP binding site [chemical binding]; other site 1091500003059 Walker B motif; other site 1091500003060 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1091500003061 potential frameshift: common BLAST hit: gi|340626315|ref|YP_004744767.1| putative peptide chain release factor 1 PRFA (RF-1) 1091500003062 potential frameshift: common BLAST hit: gi|340626315|ref|YP_004744767.1| putative peptide chain release factor 1 PRFA (RF-1) 1091500003063 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1091500003064 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091500003065 S-adenosylmethionine binding site [chemical binding]; other site 1091500003066 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1091500003067 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1091500003068 Mg++ binding site [ion binding]; other site 1091500003069 putative catalytic motif [active] 1091500003070 substrate binding site [chemical binding]; other site 1091500003071 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1091500003072 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1091500003073 F0F1 ATP synthase subunit C; Validated; Region: PRK05880 1091500003074 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1091500003075 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1091500003076 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13428 1091500003077 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1091500003078 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 1091500003079 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1091500003080 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1091500003081 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1091500003082 Walker A motif; other site 1091500003083 ATP binding site [chemical binding]; other site 1091500003084 Walker B motif; other site 1091500003085 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1091500003086 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1091500003087 core domain interface [polypeptide binding]; other site 1091500003088 delta subunit interface [polypeptide binding]; other site 1091500003089 epsilon subunit interface [polypeptide binding]; other site 1091500003090 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1091500003091 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1091500003092 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1091500003093 alpha subunit interaction interface [polypeptide binding]; other site 1091500003094 Walker A motif; other site 1091500003095 ATP binding site [chemical binding]; other site 1091500003096 Walker B motif; other site 1091500003097 inhibitor binding site; inhibition site 1091500003098 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1091500003099 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1091500003100 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1091500003101 gamma subunit interface [polypeptide binding]; other site 1091500003102 epsilon subunit interface [polypeptide binding]; other site 1091500003103 LBP interface [polypeptide binding]; other site 1091500003104 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 1091500003105 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1091500003106 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1091500003107 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 1091500003108 potential frameshift: common BLAST hit: gi|340626330|ref|YP_004744782.1| putative UDP-N-acetylglucosamine 1-carboxyvinyltransferase MURA 1091500003109 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 1091500003110 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1091500003111 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1091500003112 DNA binding site [nucleotide binding] 1091500003113 active site 1091500003114 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1091500003115 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 1091500003116 helix-hairpin-helix signature motif; other site 1091500003117 substrate binding pocket [chemical binding]; other site 1091500003118 active site 1091500003119 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 1091500003120 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1091500003121 AlkA N-terminal domain; Region: AlkA_N; pfam06029 1091500003122 HAMP domain; Region: HAMP; pfam00672 1091500003123 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1091500003124 cyclase homology domain; Region: CHD; cd07302 1091500003125 nucleotidyl binding site; other site 1091500003126 metal binding site [ion binding]; metal-binding site 1091500003127 dimer interface [polypeptide binding]; other site 1091500003128 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1091500003129 dimerization interface [polypeptide binding]; other site 1091500003130 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1091500003131 cyclase homology domain; Region: CHD; cd07302 1091500003132 nucleotidyl binding site; other site 1091500003133 metal binding site [ion binding]; metal-binding site 1091500003134 dimer interface [polypeptide binding]; other site 1091500003135 potential frameshift: common BLAST hit: gi|340626336|ref|YP_004744788.1| putative adenylate cyclase 1091500003136 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 1091500003137 hypothetical protein; Provisional; Region: PRK03298 1091500003138 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 1091500003139 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1091500003140 dimer interface [polypeptide binding]; other site 1091500003141 substrate binding site [chemical binding]; other site 1091500003142 putative acyltransferase; Provisional; Region: PRK05790 1091500003143 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1091500003144 dimer interface [polypeptide binding]; other site 1091500003145 active site 1091500003146 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 1091500003147 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 1091500003148 PE family; Region: PE; pfam00934 1091500003149 potential frameshift: common BLAST hit: gi|253799626|ref|YP_003032627.1| glycogen branching enzyme 1091500003150 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 1091500003151 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 1091500003152 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1091500003153 active site 1091500003154 homodimer interface [polypeptide binding]; other site 1091500003155 catalytic site [active] 1091500003156 acceptor binding site [chemical binding]; other site 1091500003157 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 1091500003158 putative homodimer interface [polypeptide binding]; other site 1091500003159 putative active site pocket [active] 1091500003160 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 1091500003161 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1091500003162 DEAD/DEAH box helicase; Region: DEAD; pfam00270 1091500003163 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1091500003164 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1091500003165 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 1091500003166 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 1091500003167 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 1091500003168 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 1091500003169 putative active site pocket [active] 1091500003170 cleavage site 1091500003171 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 1091500003172 MPN+ (JAMM) motif; other site 1091500003173 Zinc-binding site [ion binding]; other site 1091500003174 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1091500003175 MoaE interaction surface [polypeptide binding]; other site 1091500003176 MoeB interaction surface [polypeptide binding]; other site 1091500003177 thiocarboxylated glycine; other site 1091500003178 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 1091500003179 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1091500003180 dimer interface [polypeptide binding]; other site 1091500003181 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1091500003182 catalytic residue [active] 1091500003183 Rhomboid family; Region: Rhomboid; pfam01694 1091500003184 potential frameshift: common BLAST hit: gi|339631407|ref|YP_004723049.1| glutamate racemase 1091500003185 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1091500003186 ribonuclease PH; Reviewed; Region: rph; PRK00173 1091500003187 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1091500003188 hexamer interface [polypeptide binding]; other site 1091500003189 active site 1091500003190 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1091500003191 active site 1091500003192 dimerization interface [polypeptide binding]; other site 1091500003193 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 1091500003194 Glucitol operon activator [Transcription]; Region: GutM; COG4578 1091500003195 acyl carrier protein; Validated; Region: PRK05883 1091500003196 long-chain-fatty-acid--[acyl-carrier-protein] ligase; Validated; Region: PRK05851 1091500003197 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1091500003198 acyl-activating enzyme (AAE) consensus motif; other site 1091500003199 active site 1091500003200 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1091500003201 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1091500003202 active site 1091500003203 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1091500003204 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 1091500003205 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1091500003206 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1091500003207 FAD binding pocket [chemical binding]; other site 1091500003208 FAD binding motif [chemical binding]; other site 1091500003209 phosphate binding motif [ion binding]; other site 1091500003210 NAD binding pocket [chemical binding]; other site 1091500003211 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1091500003212 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1091500003213 Walker A/P-loop; other site 1091500003214 ATP binding site [chemical binding]; other site 1091500003215 Q-loop/lid; other site 1091500003216 ABC transporter signature motif; other site 1091500003217 Walker B; other site 1091500003218 D-loop; other site 1091500003219 H-loop/switch region; other site 1091500003220 potential frameshift: common BLAST hit: gi|340626365|ref|YP_004744817.1| putative drugs-transport transmembrane ATP-binding protein ABC 1091500003221 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1091500003222 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1091500003223 NAD(P) binding site [chemical binding]; other site 1091500003224 active site 1091500003225 potential frameshift: common BLAST hit: gi|340626369|ref|YP_004744821.1| putative transcriptional regulatory protein 1091500003226 GAF domain; Region: GAF; cl17456 1091500003227 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1091500003228 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1091500003229 metal binding site [ion binding]; metal-binding site 1091500003230 active site 1091500003231 I-site; other site 1091500003232 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1091500003233 hypothetical protein; Provisional; Region: PRK07877 1091500003234 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 1091500003235 ATP binding site [chemical binding]; other site 1091500003236 substrate interface [chemical binding]; other site 1091500003237 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1091500003238 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1091500003239 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1091500003240 cyclase homology domain; Region: CHD; cd07302 1091500003241 nucleotidyl binding site; other site 1091500003242 dimer interface [polypeptide binding]; other site 1091500003243 metal binding site [ion binding]; metal-binding site 1091500003244 potential frameshift: common BLAST hit: gi|375296834|ref|YP_005101101.1| transcriptional regulator 1091500003245 Predicted ATPase [General function prediction only]; Region: COG3903 1091500003246 Predicted ATPase [General function prediction only]; Region: COG3903 1091500003247 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1091500003248 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1091500003249 DNA binding residues [nucleotide binding] 1091500003250 dimerization interface [polypeptide binding]; other site 1091500003251 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1091500003252 cyclase homology domain; Region: CHD; cd07302 1091500003253 probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841 1091500003254 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1091500003255 potential frameshift: common BLAST hit: gi|148822583|ref|YP_001287337.1| PPE family protein 1091500003256 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1091500003257 anti sigma factor interaction site; other site 1091500003258 regulatory phosphorylation site [posttranslational modification]; other site 1091500003259 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1091500003260 synthetase active site [active] 1091500003261 NTP binding site [chemical binding]; other site 1091500003262 metal binding site [ion binding]; metal-binding site 1091500003263 Beta-lactamase; Region: Beta-lactamase; pfam00144 1091500003264 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1091500003265 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 1091500003266 putative transposase OrfB; Reviewed; Region: PHA02517 1091500003267 HTH-like domain; Region: HTH_21; pfam13276 1091500003268 Integrase core domain; Region: rve; pfam00665 1091500003269 Integrase core domain; Region: rve_3; pfam13683 1091500003270 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1091500003271 Transposase; Region: HTH_Tnp_1; cl17663 1091500003272 Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; pfam00173 1091500003273 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1091500003274 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 1091500003275 putative di-iron ligands [ion binding]; other site 1091500003276 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 1091500003277 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 1091500003278 malonyl-CoA binding site [chemical binding]; other site 1091500003279 dimer interface [polypeptide binding]; other site 1091500003280 active site 1091500003281 product binding site; other site 1091500003282 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 1091500003283 uncharacterized domain; Region: TIGR00702 1091500003284 YcaO-like family; Region: YcaO; pfam02624 1091500003285 Uncharacterized conserved protein [Function unknown]; Region: COG3482 1091500003286 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091500003287 S-adenosylmethionine binding site [chemical binding]; other site 1091500003288 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1091500003289 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1091500003290 active site 1091500003291 bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; Provisional; Region: PRK05205 1091500003292 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1091500003293 potential frameshift: common BLAST hit: gi|340626394|ref|YP_004744846.1| putative aspartate carbamoyltransferase PYRB 1091500003294 dihydroorotase; Validated; Region: pyrC; PRK09357 1091500003295 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1091500003296 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1091500003297 active site 1091500003298 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 1091500003299 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1091500003300 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1091500003301 catalytic site [active] 1091500003302 subunit interface [polypeptide binding]; other site 1091500003303 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1091500003304 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1091500003305 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1091500003306 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1091500003307 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1091500003308 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1091500003309 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1091500003310 IMP binding site; other site 1091500003311 dimer interface [polypeptide binding]; other site 1091500003312 interdomain contacts; other site 1091500003313 partial ornithine binding site; other site 1091500003314 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1091500003315 active site 1091500003316 dimer interface [polypeptide binding]; other site 1091500003317 PE family; Region: PE; pfam00934 1091500003318 potential frameshift: common BLAST hit: gi|339631454|ref|YP_004723096.1| PPE family protein 1091500003319 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1091500003320 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1091500003321 catalytic site [active] 1091500003322 G-X2-G-X-G-K; other site 1091500003323 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 1091500003324 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1091500003325 Flavoprotein; Region: Flavoprotein; pfam02441 1091500003326 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1091500003327 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1091500003328 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1091500003329 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1091500003330 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1091500003331 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1091500003332 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1091500003333 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1091500003334 Cytochrome P450; Region: p450; cl12078 1091500003335 potential frameshift: common BLAST hit: gi|339631462|ref|YP_004723104.1| transcriptional regulator 1091500003336 PE family; Region: PE; pfam00934 1091500003337 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1091500003338 oligomeric interface; other site 1091500003339 putative active site [active] 1091500003340 homodimer interface [polypeptide binding]; other site 1091500003341 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1091500003342 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1091500003343 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1091500003344 substrate binding pocket [chemical binding]; other site 1091500003345 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1091500003346 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1091500003347 substrate binding pocket [chemical binding]; other site 1091500003348 Predicted membrane protein [Function unknown]; Region: COG3714 1091500003349 potential frameshift: common BLAST hit: gi|340626416|ref|YP_004744868.1| putative primosomal protein N' PRIA 1091500003350 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091500003351 S-adenosylmethionine binding site [chemical binding]; other site 1091500003352 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1091500003353 MarR family; Region: MarR; pfam01047 1091500003354 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091500003355 S-adenosylmethionine binding site [chemical binding]; other site 1091500003356 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1091500003357 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1091500003358 putative active site [active] 1091500003359 substrate binding site [chemical binding]; other site 1091500003360 putative cosubstrate binding site; other site 1091500003361 catalytic site [active] 1091500003362 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1091500003363 substrate binding site [chemical binding]; other site 1091500003364 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 1091500003365 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 1091500003366 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 1091500003367 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1091500003368 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 1091500003369 substrate binding site [chemical binding]; other site 1091500003370 hexamer interface [polypeptide binding]; other site 1091500003371 metal binding site [ion binding]; metal-binding site 1091500003372 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1091500003373 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1091500003374 catalytic motif [active] 1091500003375 Zn binding site [ion binding]; other site 1091500003376 RibD C-terminal domain; Region: RibD_C; pfam01872 1091500003377 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1091500003378 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1091500003379 putative substrate translocation pore; other site 1091500003380 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1091500003381 Lumazine binding domain; Region: Lum_binding; pfam00677 1091500003382 Lumazine binding domain; Region: Lum_binding; pfam00677 1091500003383 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 1091500003384 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1091500003385 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1091500003386 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 1091500003387 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1091500003388 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1091500003389 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1091500003390 dimerization interface [polypeptide binding]; other site 1091500003391 active site 1091500003392 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1091500003393 homopentamer interface [polypeptide binding]; other site 1091500003394 active site 1091500003395 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1091500003396 PknH-like extracellular domain; Region: PknH_C; pfam14032 1091500003397 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1091500003398 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1091500003399 putative sugar binding sites [chemical binding]; other site 1091500003400 Q-X-W motif; other site 1091500003401 potential frameshift: common BLAST hit: gi|340626434|ref|YP_004744886.1| putative excinuclease ABC subunit C-nuclease 1091500003402 P-loop ATPase protein family; Region: ATP_bind_2; pfam03668 1091500003403 potential frameshift: common BLAST hit: gi|340626437|ref|YP_004744889.1| putative transcriptional regulatory protein WHIA 1091500003404 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1091500003405 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1091500003406 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1091500003407 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1091500003408 acyl-CoA synthetase; Provisional; Region: PRK13382 1091500003409 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1091500003410 acyl-activating enzyme (AAE) consensus motif; other site 1091500003411 putative AMP binding site [chemical binding]; other site 1091500003412 putative active site [active] 1091500003413 putative CoA binding site [chemical binding]; other site 1091500003414 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1091500003415 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 1091500003416 putative acyl-acceptor binding pocket; other site 1091500003417 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1091500003418 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1091500003419 PE family; Region: PE; pfam00934 1091500003420 PE-PPE domain; Region: PE-PPE; pfam08237 1091500003421 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 1091500003422 potential frameshift: common BLAST hit: gi|339631499|ref|YP_004723141.1| dehydrogenase 1091500003423 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 1091500003424 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1091500003425 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1091500003426 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1091500003427 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1091500003428 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1091500003429 potential frameshift: common BLAST hit: gi|339631504|ref|YP_004723146.1| phosphoglycerate kinase 1091500003430 potential frameshift: common BLAST hit: gi|339631505|ref|YP_004723147.1| triosephosphate isomerase 1091500003431 SnoaL-like domain; Region: SnoaL_2; pfam12680 1091500003432 Preprotein translocase SecG subunit; Region: SecG; cl09123 1091500003433 PE family; Region: PE; pfam00934 1091500003434 potential frameshift: common BLAST hit: gi|253799509|ref|YP_003032510.1| biotin sulfoxide reductase bisC 1091500003435 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1091500003436 hydrophobic ligand binding site; other site 1091500003437 Proteins of 100 residues with WXG; Region: WXG100; cl02005 1091500003438 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1091500003439 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 1091500003440 putative active site [active] 1091500003441 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 1091500003442 Glucose-6-P dehydrogenase subunit [Carbohydrate transport and metabolism]; Region: COG3429 1091500003443 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1091500003444 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1091500003445 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1091500003446 Class I aldolases; Region: Aldolase_Class_I; cl17187 1091500003447 potential frameshift: common BLAST hit: gi|15840908|ref|NP_335945.1| transketolase 1091500003448 PE family; Region: PE; pfam00934 1091500003449 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1091500003450 UbiA prenyltransferase family; Region: UbiA; pfam01040 1091500003451 potential frameshift: common BLAST hit: gi|148661244|ref|YP_001282767.1| PE-PGRS family protein 1091500003452 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1091500003453 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1091500003454 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 1091500003455 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 1091500003456 NADP binding site [chemical binding]; other site 1091500003457 dimer interface [polypeptide binding]; other site 1091500003458 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1091500003459 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1091500003460 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1091500003461 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1091500003462 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1091500003463 Walker A/P-loop; other site 1091500003464 ATP binding site [chemical binding]; other site 1091500003465 Q-loop/lid; other site 1091500003466 ABC transporter signature motif; other site 1091500003467 Walker B; other site 1091500003468 D-loop; other site 1091500003469 H-loop/switch region; other site 1091500003470 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 1091500003471 Predicted transcriptional regulator [Transcription]; Region: COG2345 1091500003472 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1091500003473 putative DNA binding site [nucleotide binding]; other site 1091500003474 putative Zn2+ binding site [ion binding]; other site 1091500003475 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1091500003476 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1091500003477 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1091500003478 protein-splicing catalytic site; other site 1091500003479 thioester formation/cholesterol transfer; other site 1091500003480 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 1091500003481 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 1091500003482 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1091500003483 potential frameshift: common BLAST hit: gi|253799489|ref|YP_003032490.1| FeS assembly protein SufD 1091500003484 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1091500003485 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1091500003486 Walker A/P-loop; other site 1091500003487 ATP binding site [chemical binding]; other site 1091500003488 Q-loop/lid; other site 1091500003489 ABC transporter signature motif; other site 1091500003490 Walker B; other site 1091500003491 D-loop; other site 1091500003492 H-loop/switch region; other site 1091500003493 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1091500003494 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1091500003495 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1091500003496 catalytic residue [active] 1091500003497 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1091500003498 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1091500003499 trimerization site [polypeptide binding]; other site 1091500003500 active site 1091500003501 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1091500003502 potential frameshift: common BLAST hit: gi|339631534|ref|YP_004723176.1| acyl-CoA dehydrogenase 1091500003503 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 1091500003504 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1091500003505 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1091500003506 catalytic residues [active] 1091500003507 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1091500003508 catalytic residues [active] 1091500003509 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1091500003510 substrate binding site [chemical binding]; other site 1091500003511 oxyanion hole (OAH) forming residues; other site 1091500003512 trimer interface [polypeptide binding]; other site 1091500003513 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1091500003514 potential frameshift: common BLAST hit: gi|339631540|ref|YP_004723182.1| macrolide ABC transporter ATP-binding protein 1091500003515 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1091500003516 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1091500003517 potential frameshift: common BLAST hit: gi|339631543|ref|YP_004723185.1| aconitate hydratase 1091500003518 potential frameshift: common BLAST hit: gi|339631543|ref|YP_004723185.1| aconitate hydratase 1091500003519 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1091500003520 NlpC/P60 family; Region: NLPC_P60; cl17555 1091500003521 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1091500003522 NlpC/P60 family; Region: NLPC_P60; pfam00877 1091500003523 MoxR-like ATPases [General function prediction only]; Region: COG0714 1091500003524 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1091500003525 Walker A motif; other site 1091500003526 ATP binding site [chemical binding]; other site 1091500003527 Walker B motif; other site 1091500003528 arginine finger; other site 1091500003529 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1091500003530 Protein of unknown function DUF58; Region: DUF58; pfam01882 1091500003531 hypothetical protein; Provisional; Region: PRK13685 1091500003532 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1091500003533 metal ion-dependent adhesion site (MIDAS); other site 1091500003534 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1091500003535 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1091500003536 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1091500003537 NAD(P) binding site [chemical binding]; other site 1091500003538 homotetramer interface [polypeptide binding]; other site 1091500003539 homodimer interface [polypeptide binding]; other site 1091500003540 active site 1091500003541 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 1091500003542 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1091500003543 NAD binding site [chemical binding]; other site 1091500003544 homotetramer interface [polypeptide binding]; other site 1091500003545 homodimer interface [polypeptide binding]; other site 1091500003546 substrate binding site [chemical binding]; other site 1091500003547 active site 1091500003548 potential frameshift: common BLAST hit: gi|340626500|ref|YP_004744952.1| ferrochelatase HEMZ 1091500003549 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 1091500003550 potential frameshift: common BLAST hit: gi|224989894|ref|YP_002644581.1| exported conserved protein 1091500003551 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 1091500003552 Transposase domain (DUF772); Region: DUF772; pfam05598 1091500003553 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1091500003554 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1091500003555 potential frameshift: common BLAST hit: gi|253799456|ref|YP_003032457.1| methylmalonyl-CoA mutase small subunit mutA 1091500003556 potential frameshift: common BLAST hit: gi|340626509|ref|YP_004744961.1| putative methylmalonyl-CoA mutase large subunit MUTB 1091500003557 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 1091500003558 potential frameshift: common BLAST hit: gi|340626512|ref|YP_004744964.1| putative transport system kinase 1091500003559 potential frameshift: common BLAST hit: gi|253799451|ref|YP_003032452.1| esterase lipL 1091500003560 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1091500003561 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091500003562 S-adenosylmethionine binding site [chemical binding]; other site 1091500003563 Uncharacterized conserved protein [Function unknown]; Region: COG3360 1091500003564 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1091500003565 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1091500003566 Ligand binding site; other site 1091500003567 Putative Catalytic site; other site 1091500003568 DXD motif; other site 1091500003569 Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5285 1091500003570 Glycosyl hydrolase families 32 and 68, which for the clan GH-J; Region: GH_J; cd08979 1091500003571 active site 1091500003572 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1091500003573 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1091500003574 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1091500003575 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1091500003576 inhibitor-cofactor binding pocket; inhibition site 1091500003577 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1091500003578 catalytic residue [active] 1091500003579 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 1091500003580 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 1091500003581 putative trimer interface [polypeptide binding]; other site 1091500003582 putative CoA binding site [chemical binding]; other site 1091500003583 Methyltransferase domain; Region: Methyltransf_12; pfam08242 1091500003584 S-adenosylmethionine binding site [chemical binding]; other site 1091500003585 WbqC-like protein family; Region: WbqC; pfam08889 1091500003586 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 1091500003587 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1091500003588 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1091500003589 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 1091500003590 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 1091500003591 NADP-binding site; other site 1091500003592 homotetramer interface [polypeptide binding]; other site 1091500003593 substrate binding site [chemical binding]; other site 1091500003594 homodimer interface [polypeptide binding]; other site 1091500003595 active site 1091500003596 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 1091500003597 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 1091500003598 NADP binding site [chemical binding]; other site 1091500003599 active site 1091500003600 putative substrate binding site [chemical binding]; other site 1091500003601 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 1091500003602 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 1091500003603 metal-binding site 1091500003604 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091500003605 S-adenosylmethionine binding site [chemical binding]; other site 1091500003606 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1091500003607 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1091500003608 active site 1091500003609 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 1091500003610 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1091500003611 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1091500003612 active site 1091500003613 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1091500003614 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1091500003615 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1091500003616 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1091500003617 AMP-binding enzyme; Region: AMP-binding; pfam00501 1091500003618 acyl-activating enzyme (AAE) consensus motif; other site 1091500003619 active site 1091500003620 Transport protein; Region: actII; TIGR00833 1091500003621 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1091500003622 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1091500003623 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091500003624 S-adenosylmethionine binding site [chemical binding]; other site 1091500003625 potential frameshift: common BLAST hit: gi|340626543|ref|YP_004744995.1| putative glycosyltransferase 1091500003626 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1091500003627 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1091500003628 Probable Catalytic site; other site 1091500003629 metal-binding site 1091500003630 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1091500003631 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1091500003632 homodimer interface [polypeptide binding]; other site 1091500003633 active site 1091500003634 TDP-binding site; other site 1091500003635 acceptor substrate-binding pocket; other site 1091500003636 potential frameshift: common BLAST hit: gi|253799418|ref|YP_003032419.1| polyketide synthase 1091500003637 acyl-CoA synthetase; Validated; Region: PRK05850 1091500003638 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1091500003639 acyl-activating enzyme (AAE) consensus motif; other site 1091500003640 active site 1091500003641 potential frameshift: common BLAST hit: gi|224989926|ref|YP_002644613.1| alcohol dehydrogenase 1091500003642 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1091500003643 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1091500003644 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1091500003645 CoenzymeA binding site [chemical binding]; other site 1091500003646 subunit interaction site [polypeptide binding]; other site 1091500003647 PHB binding site; other site 1091500003648 Nitronate monooxygenase; Region: NMO; pfam03060 1091500003649 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1091500003650 FMN binding site [chemical binding]; other site 1091500003651 substrate binding site [chemical binding]; other site 1091500003652 putative catalytic residue [active] 1091500003653 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1091500003654 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1091500003655 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 1091500003656 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1091500003657 HIGH motif; other site 1091500003658 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1091500003659 active site 1091500003660 KMSKS motif; other site 1091500003661 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 1091500003662 tRNA binding surface [nucleotide binding]; other site 1091500003663 anticodon binding site; other site 1091500003664 DNA polymerase IV; Provisional; Region: PRK03348 1091500003665 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1091500003666 active site 1091500003667 DNA binding site [nucleotide binding] 1091500003668 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1091500003669 active site 1091500003670 homodimer interface [polypeptide binding]; other site 1091500003671 homotetramer interface [polypeptide binding]; other site 1091500003672 lipoprotein signal peptidase; Provisional; Region: PRK14764 1091500003673 lipoprotein signal peptidase; Provisional; Region: PRK14787 1091500003674 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1091500003675 active site 1091500003676 Uncharacterized protein conserved in bacteria, putative lipoprotein [Function unknown]; Region: LprI; COG4461 1091500003677 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 1091500003678 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 1091500003679 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1091500003680 apolar tunnel; other site 1091500003681 heme binding site [chemical binding]; other site 1091500003682 dimerization interface [polypeptide binding]; other site 1091500003683 potential frameshift: common BLAST hit: gi|340626564|ref|YP_004745016.1| putative fatty acyl-CoA reductase 1091500003684 classical (c) SDRs; Region: SDR_c; cd05233 1091500003685 active site 1091500003686 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1091500003687 hydrophobic ligand binding site; other site 1091500003688 potential frameshift: common BLAST hit: gi|339631618|ref|YP_004723260.1| DNA polymerase III subunit alpha 1091500003689 potential frameshift: common BLAST hit: gi|339631618|ref|YP_004723260.1| DNA polymerase III subunit alpha 1091500003690 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1091500003691 PPE family; Region: PPE; pfam00823 1091500003692 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1091500003693 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1091500003694 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1091500003695 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1091500003696 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1091500003697 acyl-activating enzyme (AAE) consensus motif; other site 1091500003698 putative active site [active] 1091500003699 putative AMP binding site [chemical binding]; other site 1091500003700 putative CoA binding site [chemical binding]; other site 1091500003701 glycerol-3-phosphate acyltransferase; Reviewed; Region: PRK11915 1091500003702 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 1091500003703 putative acyl-acceptor binding pocket; other site 1091500003704 potential frameshift: common BLAST hit: gi|340626572|ref|YP_004745024.1| putative fumarate reductase [flavoprotein subunit] FRDA 1091500003705 potential frameshift: common BLAST hit: gi|340626572|ref|YP_004745024.1| putative fumarate reductase [flavoprotein subunit] FRDA 1091500003706 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 1091500003707 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1091500003708 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 1091500003709 D-subunit interface [polypeptide binding]; other site 1091500003710 Iron-sulfur protein interface; other site 1091500003711 proximal quinone binding site [chemical binding]; other site 1091500003712 distal quinone binding site [chemical binding]; other site 1091500003713 Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881 1091500003714 proximal heme binding site [chemical binding]; other site 1091500003715 Iron-sulfur protein interface; other site 1091500003716 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1091500003717 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1091500003718 MMPL family; Region: MMPL; pfam03176 1091500003719 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1091500003720 threonine dehydratase; Validated; Region: PRK08639 1091500003721 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1091500003722 tetramer interface [polypeptide binding]; other site 1091500003723 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1091500003724 catalytic residue [active] 1091500003725 C-terminal regulatory domain of Threonine dehydratase; Region: Thr_dehydrat_C; pfam00585 1091500003726 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 1091500003727 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 1091500003728 putative active site [active] 1091500003729 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 1091500003730 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 1091500003731 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 1091500003732 catalytic site [active] 1091500003733 active site 1091500003734 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1091500003735 malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401 1091500003736 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 1091500003737 active site 1091500003738 catalytic site [active] 1091500003739 potential frameshift: common BLAST hit: gi|339631635|ref|YP_004723277.1| maltooligosyltrehalose synthase 1091500003740 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1091500003741 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1091500003742 NlpC/P60 family; Region: NLPC_P60; pfam00877 1091500003743 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 1091500003744 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1091500003745 inhibitor-cofactor binding pocket; inhibition site 1091500003746 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1091500003747 catalytic residue [active] 1091500003748 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 1091500003749 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 1091500003750 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1091500003751 catalytic residue [active] 1091500003752 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1091500003753 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 1091500003754 Predicted phage phi-C31 gp36 major capsid-like protein [General function prediction only]; Region: COG4653 1091500003755 Phage capsid family; Region: Phage_capsid; pfam05065 1091500003756 Phage head maturation protease [General function prediction only]; Region: COG3740 1091500003757 Phage terminase, small subunit; Region: Terminase_4; cl01525 1091500003758 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 1091500003759 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1091500003760 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1091500003761 active site 1091500003762 biotin synthase; Validated; Region: PRK06256 1091500003763 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1091500003764 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1091500003765 Protein of unknown function (DUF2567); Region: DUF2567; pfam10821 1091500003766 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 1091500003767 nudix motif; other site 1091500003768 L-aspartate oxidase; Provisional; Region: PRK07804 1091500003769 L-aspartate oxidase; Provisional; Region: PRK06175 1091500003770 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1091500003771 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 1091500003772 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1091500003773 dimerization interface [polypeptide binding]; other site 1091500003774 active site 1091500003775 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1091500003776 deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026 1091500003777 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 1091500003778 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1091500003779 NAD binding site [chemical binding]; other site 1091500003780 dimerization interface [polypeptide binding]; other site 1091500003781 product binding site; other site 1091500003782 substrate binding site [chemical binding]; other site 1091500003783 zinc binding site [ion binding]; other site 1091500003784 catalytic residues [active] 1091500003785 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 1091500003786 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1091500003787 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1091500003788 homodimer interface [polypeptide binding]; other site 1091500003789 catalytic residue [active] 1091500003790 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1091500003791 4-fold oligomerization interface [polypeptide binding]; other site 1091500003792 putative active site pocket [active] 1091500003793 metal binding residues [ion binding]; metal-binding site 1091500003794 3-fold/trimer interface [polypeptide binding]; other site 1091500003795 potential frameshift: common BLAST hit: gi|339631658|ref|YP_004723300.1| amidotransferase 1091500003796 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1091500003797 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1091500003798 catalytic residues [active] 1091500003799 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1091500003800 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1091500003801 active site 1091500003802 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1091500003803 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1091500003804 substrate binding site [chemical binding]; other site 1091500003805 glutamase interaction surface [polypeptide binding]; other site 1091500003806 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 1091500003807 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 1091500003808 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1091500003809 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1091500003810 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1091500003811 catalytic triad [active] 1091500003812 anthranilate synthase component I; Provisional; Region: PRK13571 1091500003813 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1091500003814 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1091500003815 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534 1091500003816 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1091500003817 active site 1091500003818 ribulose/triose binding site [chemical binding]; other site 1091500003819 phosphate binding site [ion binding]; other site 1091500003820 substrate (anthranilate) binding pocket [chemical binding]; other site 1091500003821 product (indole) binding pocket [chemical binding]; other site 1091500003822 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1091500003823 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1091500003824 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1091500003825 catalytic residue [active] 1091500003826 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1091500003827 substrate binding site [chemical binding]; other site 1091500003828 active site 1091500003829 catalytic residues [active] 1091500003830 heterodimer interface [polypeptide binding]; other site 1091500003831 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK13108 1091500003832 Prolipoprotein diacylglyceryltransferase [Cell envelope biogenesis, outer membrane]; Region: Lgt; COG0682 1091500003833 TM2 domain; Region: TM2; pfam05154 1091500003834 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 1091500003835 pyruvate kinase; Provisional; Region: PRK06247 1091500003836 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1091500003837 domain interfaces; other site 1091500003838 active site 1091500003839 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 1091500003840 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1091500003841 active site 1091500003842 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1091500003843 catalytic triad [active] 1091500003844 dimer interface [polypeptide binding]; other site 1091500003845 Uncharacterized conserved protein [Function unknown]; Region: COG2898 1091500003846 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1091500003847 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 1091500003848 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1091500003849 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1091500003850 Walker A/P-loop; other site 1091500003851 Walker A/P-loop; other site 1091500003852 ATP binding site [chemical binding]; other site 1091500003853 ATP binding site [chemical binding]; other site 1091500003854 Q-loop/lid; other site 1091500003855 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 1091500003856 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1091500003857 Walker A/P-loop; other site 1091500003858 ATP binding site [chemical binding]; other site 1091500003859 Q-loop/lid; other site 1091500003860 ABC transporter signature motif; other site 1091500003861 Walker B; other site 1091500003862 D-loop; other site 1091500003863 H-loop/switch region; other site 1091500003864 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1091500003865 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1091500003866 potential frameshift: common BLAST hit: gi|339631679|ref|YP_004723321.1| cytochrome D ubiquinol oxidase subunit I 1091500003867 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 1091500003868 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 1091500003869 cyclase homology domain; Region: CHD; cd07302 1091500003870 nucleotidyl binding site; other site 1091500003871 metal binding site [ion binding]; metal-binding site 1091500003872 dimer interface [polypeptide binding]; other site 1091500003873 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 1091500003874 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091500003875 active site 1091500003876 phosphorylation site [posttranslational modification] 1091500003877 intermolecular recognition site; other site 1091500003878 dimerization interface [polypeptide binding]; other site 1091500003879 ANTAR domain; Region: ANTAR; pfam03861 1091500003880 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1091500003881 lipid-transfer protein; Provisional; Region: PRK06059 1091500003882 active site 1091500003883 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1091500003884 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1091500003885 DUF35 OB-fold domain; Region: DUF35; pfam01796 1091500003886 DNA polymerase I; Provisional; Region: PRK05755 1091500003887 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1091500003888 active site 1091500003889 metal binding site 1 [ion binding]; metal-binding site 1091500003890 putative 5' ssDNA interaction site; other site 1091500003891 metal binding site 3; metal-binding site 1091500003892 metal binding site 2 [ion binding]; metal-binding site 1091500003893 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1091500003894 putative DNA binding site [nucleotide binding]; other site 1091500003895 putative metal binding site [ion binding]; other site 1091500003896 3'-5' exonuclease; Region: 35EXOc; smart00474 1091500003897 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1091500003898 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1091500003899 active site 1091500003900 DNA binding site [nucleotide binding] 1091500003901 catalytic site [active] 1091500003902 potential frameshift: common BLAST hit: gi|224990012|ref|YP_002644699.1| 30S ribosomal protein S1 1091500003903 potential frameshift: common BLAST hit: gi|339631687|ref|YP_004723329.1| dephospho-CoA kinase 1091500003904 Predicted RNA-binding protein, associated with RNAses E/G family [General function prediction only]; Region: COG2306 1091500003905 excinuclease ABC subunit B; Provisional; Region: PRK05298 1091500003906 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1091500003907 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1091500003908 nucleotide binding region [chemical binding]; other site 1091500003909 ATP-binding site [chemical binding]; other site 1091500003910 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1091500003911 UvrB/uvrC motif; Region: UVR; pfam02151 1091500003912 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1091500003913 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1091500003914 putative substrate translocation pore; other site 1091500003915 Predicted membrane protein [Function unknown]; Region: COG5305 1091500003916 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1091500003917 Ligand Binding Site [chemical binding]; other site 1091500003918 potential frameshift: common BLAST hit: gi|340626642|ref|YP_004745094.1| metallo-beta-lactamase superfamily protein 1091500003919 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1091500003920 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1091500003921 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1091500003922 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1091500003923 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1091500003924 Predicted esterase [General function prediction only]; Region: COG0627 1091500003925 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 1091500003926 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1091500003927 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1091500003928 dimer interface [polypeptide binding]; other site 1091500003929 putative anticodon binding site; other site 1091500003930 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1091500003931 motif 1; other site 1091500003932 dimer interface [polypeptide binding]; other site 1091500003933 active site 1091500003934 motif 2; other site 1091500003935 motif 3; other site 1091500003936 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1091500003937 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1091500003938 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1091500003939 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1091500003940 23S rRNA binding site [nucleotide binding]; other site 1091500003941 L21 binding site [polypeptide binding]; other site 1091500003942 L13 binding site [polypeptide binding]; other site 1091500003943 potential frameshift: common BLAST hit: gi|340626650|ref|YP_004745102.1| putative 23S rRNA methyltransferase tsnR 1091500003944 PE family; Region: PE; pfam00934 1091500003945 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1091500003946 cyclase homology domain; Region: CHD; cd07302 1091500003947 nucleotidyl binding site; other site 1091500003948 metal binding site [ion binding]; metal-binding site 1091500003949 dimer interface [polypeptide binding]; other site 1091500003950 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1091500003951 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1091500003952 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1091500003953 dimer interface [polypeptide binding]; other site 1091500003954 motif 1; other site 1091500003955 active site 1091500003956 motif 2; other site 1091500003957 motif 3; other site 1091500003958 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1091500003959 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1091500003960 putative tRNA-binding site [nucleotide binding]; other site 1091500003961 B3/4 domain; Region: B3_4; pfam03483 1091500003962 tRNA synthetase B5 domain; Region: B5; smart00874 1091500003963 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1091500003964 dimer interface [polypeptide binding]; other site 1091500003965 motif 1; other site 1091500003966 motif 3; other site 1091500003967 motif 2; other site 1091500003968 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1091500003969 potential frameshift: common BLAST hit: gi|224990034|ref|YP_002644721.1| PE-PGRS family protein 1091500003970 potential frameshift: common BLAST hit: gi|253799309|ref|YP_003032310.1| PE-PGRS family protein 1091500003971 N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850 1091500003972 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1091500003973 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1091500003974 heterotetramer interface [polypeptide binding]; other site 1091500003975 active site pocket [active] 1091500003976 cleavage site 1091500003977 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 1091500003978 feedback inhibition sensing region; other site 1091500003979 homohexameric interface [polypeptide binding]; other site 1091500003980 nucleotide binding site [chemical binding]; other site 1091500003981 N-acetyl-L-glutamate binding site [chemical binding]; other site 1091500003982 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 1091500003983 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1091500003984 inhibitor-cofactor binding pocket; inhibition site 1091500003985 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1091500003986 catalytic residue [active] 1091500003987 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1091500003988 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1091500003989 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1091500003990 arginine repressor; Provisional; Region: PRK03341 1091500003991 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1091500003992 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1091500003993 argininosuccinate synthase; Provisional; Region: PRK13820 1091500003994 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1091500003995 ANP binding site [chemical binding]; other site 1091500003996 Substrate Binding Site II [chemical binding]; other site 1091500003997 Substrate Binding Site I [chemical binding]; other site 1091500003998 argininosuccinate lyase; Provisional; Region: PRK00855 1091500003999 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1091500004000 active sites [active] 1091500004001 tetramer interface [polypeptide binding]; other site 1091500004002 potential frameshift: common BLAST hit: gi|340626666|ref|YP_004745118.1| putative chalcone synthase pks10 1091500004003 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1091500004004 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1091500004005 active site 1091500004006 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1091500004007 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1091500004008 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1091500004009 Enoylreductase; Region: PKS_ER; smart00829 1091500004010 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1091500004011 NAD(P) binding site [chemical binding]; other site 1091500004012 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 1091500004013 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1091500004014 putative NADP binding site [chemical binding]; other site 1091500004015 active site 1091500004016 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1091500004017 potential frameshift: common BLAST hit: gi|148822871|ref|YP_001287625.1| polyketide synthase pks8 1091500004018 potential frameshift: common BLAST hit: gi|253799298|ref|YP_003032299.1| polyketide synthase 1091500004019 potential frameshift: common BLAST hit: gi|340626668|ref|YP_004745120.1| polyketide synthase PKS8 1091500004020 potential frameshift: common BLAST hit: gi|148661458|ref|YP_001282981.1| polyketide synthase Pks8 1091500004021 potential frameshift: common BLAST hit: gi|224990046|ref|YP_002644733.1| polyketide synthase 1091500004022 potential frameshift: common BLAST hit: gi|224990046|ref|YP_002644733.1| polyketide synthase 1091500004023 potential frameshift: common BLAST hit: gi|253799296|ref|YP_003032297.1| polyketide synthase 1091500004024 Acyl transferase domain; Region: Acyl_transf_1; cl08282 1091500004025 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1091500004026 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 1091500004027 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 1091500004028 malonyl-CoA binding site [chemical binding]; other site 1091500004029 dimer interface [polypeptide binding]; other site 1091500004030 active site 1091500004031 product binding site; other site 1091500004032 potential frameshift: common BLAST hit: gi|15841122|ref|NP_336159.1| P450 heme-thiolate protein 1091500004033 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1091500004034 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1091500004035 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1091500004036 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 1091500004037 ABC transporter; Region: ABC_tran_2; pfam12848 1091500004038 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1091500004039 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 1091500004040 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1091500004041 putative substrate translocation pore; other site 1091500004042 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1091500004043 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1091500004044 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1091500004045 dimerization interface [polypeptide binding]; other site 1091500004046 putative DNA binding site [nucleotide binding]; other site 1091500004047 putative Zn2+ binding site [ion binding]; other site 1091500004048 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1091500004049 active site residue [active] 1091500004050 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1091500004051 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1091500004052 ligand binding site [chemical binding]; other site 1091500004053 flexible hinge region; other site 1091500004054 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1091500004055 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 1091500004056 putative catalytic residues [active] 1091500004057 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1091500004058 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1091500004059 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1091500004060 active site 1091500004061 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 1091500004062 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1091500004063 substrate binding pocket [chemical binding]; other site 1091500004064 membrane-bound complex binding site; other site 1091500004065 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 1091500004066 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1091500004067 FeS/SAM binding site; other site 1091500004068 DivIVA protein; Region: DivIVA; pfam05103 1091500004069 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1091500004070 potential frameshift: common BLAST hit: gi|224990065|ref|YP_002644752.1| acyl-CoA synthetase 1091500004071 Uncharacterized conserved protein [Function unknown]; Region: COG2835 1091500004072 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1091500004073 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1091500004074 ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025 1091500004075 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1091500004076 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1091500004077 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 1091500004078 Walker A/P-loop; other site 1091500004079 ATP binding site [chemical binding]; other site 1091500004080 Q-loop/lid; other site 1091500004081 ABC transporter signature motif; other site 1091500004082 Walker B; other site 1091500004083 D-loop; other site 1091500004084 H-loop/switch region; other site 1091500004085 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1091500004086 active site 1091500004087 DNA binding site [nucleotide binding] 1091500004088 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1091500004089 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1091500004090 active site 1091500004091 HIGH motif; other site 1091500004092 dimer interface [polypeptide binding]; other site 1091500004093 KMSKS motif; other site 1091500004094 S4 RNA-binding domain; Region: S4; smart00363 1091500004095 RNA binding surface [nucleotide binding]; other site 1091500004096 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1091500004097 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1091500004098 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 1091500004099 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 1091500004100 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1091500004101 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1091500004102 RNA binding surface [nucleotide binding]; other site 1091500004103 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091500004104 S-adenosylmethionine binding site [chemical binding]; other site 1091500004105 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 1091500004106 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1091500004107 potential frameshift: common BLAST hit: gi|340626701|ref|YP_004745153.1| putative DNA repair protein RECN 1091500004108 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 1091500004109 Thiamine pyrophosphokinase; Region: TPK; cl08415 1091500004110 Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555 1091500004111 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 1091500004112 CTP synthetase; Validated; Region: pyrG; PRK05380 1091500004113 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1091500004114 Catalytic site [active] 1091500004115 active site 1091500004116 UTP binding site [chemical binding]; other site 1091500004117 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1091500004118 active site 1091500004119 putative oxyanion hole; other site 1091500004120 catalytic triad [active] 1091500004121 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1091500004122 dimer interface [polypeptide binding]; other site 1091500004123 ADP-ribose binding site [chemical binding]; other site 1091500004124 active site 1091500004125 nudix motif; other site 1091500004126 metal binding site [ion binding]; metal-binding site 1091500004127 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1091500004128 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1091500004129 active site 1091500004130 DNA binding site [nucleotide binding] 1091500004131 Int/Topo IB signature motif; other site 1091500004132 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1091500004133 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1091500004134 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1091500004135 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091500004136 S-adenosylmethionine binding site [chemical binding]; other site 1091500004137 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 1091500004138 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1091500004139 PPE family; Region: PPE; pfam00823 1091500004140 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1091500004141 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1091500004142 PPE family; Region: PPE; pfam00823 1091500004143 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1091500004144 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1091500004145 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1091500004146 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1091500004147 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1091500004148 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1091500004149 P-loop; other site 1091500004150 Magnesium ion binding site [ion binding]; other site 1091500004151 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1091500004152 Magnesium ion binding site [ion binding]; other site 1091500004153 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 1091500004154 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 1091500004155 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1091500004156 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1091500004157 RNA binding surface [nucleotide binding]; other site 1091500004158 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1091500004159 active site 1091500004160 cytidylate kinase; Provisional; Region: cmk; PRK00023 1091500004161 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1091500004162 CMP-binding site; other site 1091500004163 The sites determining sugar specificity; other site 1091500004164 GTP-binding protein Der; Reviewed; Region: PRK03003 1091500004165 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1091500004166 GTP/Mg2+ binding site [chemical binding]; other site 1091500004167 Switch I region; other site 1091500004168 G2 box; other site 1091500004169 Switch II region; other site 1091500004170 G3 box; other site 1091500004171 G4 box; other site 1091500004172 G5 box; other site 1091500004173 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1091500004174 G1 box; other site 1091500004175 GTP/Mg2+ binding site [chemical binding]; other site 1091500004176 Switch I region; other site 1091500004177 G2 box; other site 1091500004178 G3 box; other site 1091500004179 Switch II region; other site 1091500004180 G4 box; other site 1091500004181 G5 box; other site 1091500004182 short chain dehydrogenase; Provisional; Region: PRK07060 1091500004183 classical (c) SDRs; Region: SDR_c; cd05233 1091500004184 NAD(P) binding site [chemical binding]; other site 1091500004185 active site 1091500004186 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 1091500004187 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1091500004188 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1091500004189 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 1091500004190 Cupin domain; Region: Cupin_2; cl17218 1091500004191 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 1091500004192 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1091500004193 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1091500004194 putative switch regulator; other site 1091500004195 non-specific DNA interactions [nucleotide binding]; other site 1091500004196 DNA binding site [nucleotide binding] 1091500004197 sequence specific DNA binding site [nucleotide binding]; other site 1091500004198 putative cAMP binding site [chemical binding]; other site 1091500004199 Bacterial transcriptional regulator; Region: IclR; pfam01614 1091500004200 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 1091500004201 putative active site [active] 1091500004202 homotetrameric interface [polypeptide binding]; other site 1091500004203 metal binding site [ion binding]; metal-binding site 1091500004204 biotin carboxylase-like protein; Validated; Region: PRK06524 1091500004205 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1091500004206 Beta-lactamase; Region: Beta-lactamase; pfam00144 1091500004207 Predicted transcriptional regulators [Transcription]; Region: COG1733 1091500004208 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1091500004209 dimerization interface [polypeptide binding]; other site 1091500004210 putative DNA binding site [nucleotide binding]; other site 1091500004211 putative Zn2+ binding site [ion binding]; other site 1091500004212 Predicted transcriptional regulators [Transcription]; Region: COG1733 1091500004213 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1091500004214 FAD binding domain; Region: FAD_binding_4; pfam01565 1091500004215 Berberine and berberine like; Region: BBE; pfam08031 1091500004216 TIGR03086 family protein; Region: TIGR03086 1091500004217 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1091500004218 potential frameshift: common BLAST hit: gi|340626735|ref|YP_004745187.1| putative penicillin-binding protein 1091500004219 succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407 1091500004220 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101 1091500004221 NAD(P) binding site [chemical binding]; other site 1091500004222 catalytic residues [active] 1091500004223 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 1091500004224 putative catalytic residue [active] 1091500004225 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes [Energy production and conversion]; Region: AceF; COG0508 1091500004226 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1091500004227 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 1091500004228 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_1; cd09319 1091500004229 gating phenylalanine in ion channel; other site 1091500004230 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_1; cd09319 1091500004231 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1091500004232 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 1091500004233 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 1091500004234 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1091500004235 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 1091500004236 putative substrate translocation pore; other site 1091500004237 Domain of unknown function (DUF1876); Region: DUF1876; pfam08962 1091500004238 potential frameshift: common BLAST hit: gi|224990122|ref|YP_002644809.1| sulphate-transport transmembrane protein ABC transporter 1091500004239 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4423 1091500004240 Protein tyrosine kinase; Region: Pkinase_Tyr; pfam07714 1091500004241 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1091500004242 active site 1091500004243 ATP binding site [chemical binding]; other site 1091500004244 substrate binding site [chemical binding]; other site 1091500004245 activation loop (A-loop); other site 1091500004246 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1091500004247 Thioredoxin; Region: Thioredoxin_4; cl17273 1091500004248 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 1091500004249 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 1091500004250 active site 1091500004251 metal binding site [ion binding]; metal-binding site 1091500004252 nudix motif; other site 1091500004253 potential frameshift: common BLAST hit: gi|340626754|ref|YP_004745206.1| anchored-membrane serine/threonine-protein kinase 1091500004254 potential frameshift: common BLAST hit: gi|340626754|ref|YP_004745206.1| anchored-membrane serine/threonine-protein kinase 1091500004255 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1091500004256 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1091500004257 phosphopeptide binding site; other site 1091500004258 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1091500004259 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1091500004260 phosphopeptide binding site; other site 1091500004261 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 1091500004262 The Eye Pigment Precursor Transporter (EPP) Family protein; Region: 3a01204; TIGR00955 1091500004263 Walker A/P-loop; other site 1091500004264 ATP binding site [chemical binding]; other site 1091500004265 Q-loop/lid; other site 1091500004266 ABC transporter signature motif; other site 1091500004267 Walker B; other site 1091500004268 D-loop; other site 1091500004269 H-loop/switch region; other site 1091500004270 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1091500004271 acyl-CoA synthetase; Provisional; Region: PRK13388 1091500004272 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1091500004273 acyl-activating enzyme (AAE) consensus motif; other site 1091500004274 AMP binding site [chemical binding]; other site 1091500004275 active site 1091500004276 CoA binding site [chemical binding]; other site 1091500004277 hypothetical protein; Provisional; Region: PRK06185 1091500004278 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1091500004279 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1091500004280 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1091500004281 potential frameshift: common BLAST hit: gi|148661552|ref|YP_001283075.1| PPE family protein 1091500004282 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1091500004283 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1091500004284 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1091500004285 PPE family; Region: PPE; pfam00823 1091500004286 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 1091500004287 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1091500004288 putative transposase OrfB; Reviewed; Region: PHA02517 1091500004289 HTH-like domain; Region: HTH_21; pfam13276 1091500004290 Integrase core domain; Region: rve; pfam00665 1091500004291 Integrase core domain; Region: rve_3; pfam13683 1091500004292 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1091500004293 Transposase; Region: HTH_Tnp_1; cl17663 1091500004294 Cutinase; Region: Cutinase; pfam01083 1091500004295 potential frameshift: common BLAST hit: gi|57116905|ref|YP_177831.1| PE-PGRS family protein 1091500004296 potential frameshift: common BLAST hit: gi|57116905|ref|YP_177831.1| PE-PGRS family protein 1091500004297 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1091500004298 Uncharacterized conserved protein [Function unknown]; Region: COG0393 1091500004299 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 1091500004300 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1091500004301 Transposase; Region: HTH_Tnp_1; cl17663 1091500004302 putative transposase OrfB; Reviewed; Region: PHA02517 1091500004303 HTH-like domain; Region: HTH_21; pfam13276 1091500004304 Integrase core domain; Region: rve; pfam00665 1091500004305 Integrase core domain; Region: rve_3; pfam13683 1091500004306 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1091500004307 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1091500004308 active site 1091500004309 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 1091500004310 putative homotetramer interface [polypeptide binding]; other site 1091500004311 putative homodimer interface [polypeptide binding]; other site 1091500004312 putative allosteric switch controlling residues; other site 1091500004313 putative metal binding site [ion binding]; other site 1091500004314 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1091500004315 PE family; Region: PE; pfam00934 1091500004316 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 1091500004317 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813 1091500004318 dimer interface [polypeptide binding]; other site 1091500004319 active site 1091500004320 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1091500004321 substrate binding site [chemical binding]; other site 1091500004322 catalytic residue [active] 1091500004323 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 1091500004324 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1091500004325 metal binding site [ion binding]; metal-binding site 1091500004326 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 1091500004327 FAD binding domain; Region: FAD_binding_4; pfam01565 1091500004328 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 1091500004329 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 1091500004330 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1091500004331 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1091500004332 Bacterial transcriptional regulator; Region: IclR; pfam01614 1091500004333 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1091500004334 FAD binding domain; Region: FAD_binding_4; pfam01565 1091500004335 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1091500004336 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1091500004337 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1091500004338 Cytochrome P450; Region: p450; cl12078 1091500004339 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 1091500004340 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 1091500004341 Protein of unknown function (DUF690); Region: DUF690; pfam05108 1091500004342 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1091500004343 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1091500004344 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1091500004345 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1091500004346 Cytochrome P450; Region: p450; cl12078 1091500004347 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1091500004348 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1091500004349 PPE family; Region: PPE; pfam00823 1091500004350 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1091500004351 PE family; Region: PE; pfam00934 1091500004352 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1091500004353 PPE family; Region: PPE; pfam00823 1091500004354 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1091500004355 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1091500004356 PPE family; Region: PPE; pfam00823 1091500004357 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1091500004358 PE family; Region: PE; pfam00934 1091500004359 Proteins of 100 residues with WXG; Region: WXG100; cl02005 1091500004360 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1091500004361 EspG family; Region: ESX-1_EspG; pfam14011 1091500004362 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 1091500004363 potential frameshift: common BLAST hit: gi|339631850|ref|YP_004723492.1| serine protease 1091500004364 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 1091500004365 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 1091500004366 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1091500004367 Walker A motif; other site 1091500004368 ATP binding site [chemical binding]; other site 1091500004369 Walker B motif; other site 1091500004370 arginine finger; other site 1091500004371 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1091500004372 PPE family; Region: PPE; pfam00823 1091500004373 PE-PPE domain; Region: PE-PPE; pfam08237 1091500004374 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1091500004375 PPE family; Region: PPE; pfam00823 1091500004376 potential frameshift: common BLAST hit: gi|253799156|ref|YP_003032157.1| PPE family protein 1091500004377 PE family; Region: PE; pfam00934 1091500004378 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1091500004379 PE family; Region: PE; pfam00934 1091500004380 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1091500004381 PPE family; Region: PPE; pfam00823 1091500004382 potential frameshift: common BLAST hit: gi|253799148|ref|YP_003032149.1| PPE family protein 1091500004383 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1091500004384 PPE family; Region: PPE; pfam00823 1091500004385 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1091500004386 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1091500004387 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1091500004388 MgtC family; Region: MgtC; pfam02308 1091500004389 potential frameshift: common BLAST hit: gi|339631865|ref|YP_004723507.1| dehydrogenase 1091500004390 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 1091500004391 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 1091500004392 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 1091500004393 potential frameshift: common BLAST hit: gi|340626825|ref|YP_004745277.1| putative transcriptional regulatory protein 1091500004394 potential frameshift: common BLAST hit: gi|339631870|ref|YP_004723512.1| flavoprotein 1091500004395 PE family; Region: PE; pfam00934 1091500004396 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 1091500004397 ABC transporter transmembrane region 2; Region: ABC_membrane_2; pfam06472 1091500004398 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 1091500004399 hypothetical protein; Provisional; Region: PRK05858 1091500004400 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1091500004401 PYR/PP interface [polypeptide binding]; other site 1091500004402 dimer interface [polypeptide binding]; other site 1091500004403 TPP binding site [chemical binding]; other site 1091500004404 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1091500004405 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 1091500004406 TPP-binding site; other site 1091500004407 dimer interface [polypeptide binding]; other site 1091500004408 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 1091500004409 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 1091500004410 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1091500004411 nucleotide binding region [chemical binding]; other site 1091500004412 ATP-binding site [chemical binding]; other site 1091500004413 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1091500004414 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1091500004415 Protein of unknown function (DUF1290); Region: DUF1290; cl01587 1091500004416 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 1091500004417 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1091500004418 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1091500004419 lipoyl attachment site [posttranslational modification]; other site 1091500004420 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1091500004421 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1091500004422 phosphopeptide binding site; other site 1091500004423 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1091500004424 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1091500004425 DNA binding residues [nucleotide binding] 1091500004426 Bifunctional nuclease; Region: DNase-RNase; pfam02577 1091500004427 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1091500004428 DNA binding residues [nucleotide binding] 1091500004429 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1091500004430 putative dimer interface [polypeptide binding]; other site 1091500004431 glycine dehydrogenase; Provisional; Region: PRK05367 1091500004432 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1091500004433 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1091500004434 tetramer interface [polypeptide binding]; other site 1091500004435 catalytic residue [active] 1091500004436 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1091500004437 tetramer interface [polypeptide binding]; other site 1091500004438 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1091500004439 catalytic residue [active] 1091500004440 haloalkane dehalogenase; Provisional; Region: PRK03204 1091500004441 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1091500004442 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1091500004443 metal ion-dependent adhesion site (MIDAS); other site 1091500004444 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 1091500004445 active site 1091500004446 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 1091500004447 putative active site [active] 1091500004448 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1091500004449 Domain of unknown function DUF21; Region: DUF21; pfam01595 1091500004450 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1091500004451 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1091500004452 Transporter associated domain; Region: CorC_HlyC; smart01091 1091500004453 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 1091500004454 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1091500004455 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1091500004456 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1091500004457 active site 1091500004458 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1091500004459 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1091500004460 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1091500004461 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1091500004462 Predicted transcriptional regulator [Transcription]; Region: COG3682 1091500004463 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1091500004464 CoenzymeA binding site [chemical binding]; other site 1091500004465 subunit interaction site [polypeptide binding]; other site 1091500004466 PHB binding site; other site 1091500004467 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 1091500004468 alpha-gamma subunit interface [polypeptide binding]; other site 1091500004469 beta-gamma subunit interface [polypeptide binding]; other site 1091500004470 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 1091500004471 gamma-beta subunit interface [polypeptide binding]; other site 1091500004472 alpha-beta subunit interface [polypeptide binding]; other site 1091500004473 urease subunit alpha; Reviewed; Region: ureC; PRK13206 1091500004474 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 1091500004475 subunit interactions [polypeptide binding]; other site 1091500004476 active site 1091500004477 flap region; other site 1091500004478 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 1091500004479 UreF; Region: UreF; pfam01730 1091500004480 potential frameshift: common BLAST hit: gi|340626860|ref|YP_004745312.1| urease accessory protein ureG 1091500004481 UreD urease accessory protein; Region: UreD; cl00530 1091500004482 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1091500004483 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1091500004484 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 1091500004485 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1091500004486 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1091500004487 classical (c) SDRs; Region: SDR_c; cd05233 1091500004488 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 1091500004489 NAD(P) binding site [chemical binding]; other site 1091500004490 active site 1091500004491 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 1091500004492 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1091500004493 sulfate transport protein; Provisional; Region: cysT; CHL00187 1091500004494 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1091500004495 dimer interface [polypeptide binding]; other site 1091500004496 conserved gate region; other site 1091500004497 putative PBP binding loops; other site 1091500004498 ABC-ATPase subunit interface; other site 1091500004499 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1091500004500 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1091500004501 Walker A/P-loop; other site 1091500004502 ATP binding site [chemical binding]; other site 1091500004503 Q-loop/lid; other site 1091500004504 ABC transporter signature motif; other site 1091500004505 Walker B; other site 1091500004506 D-loop; other site 1091500004507 H-loop/switch region; other site 1091500004508 Fibronectin-attachment protein (FAP); Region: FAP; pfam07174 1091500004509 Predicted membrane protein [Function unknown]; Region: COG2261 1091500004510 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 1091500004511 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822 1091500004512 putative NAD(P) binding site [chemical binding]; other site 1091500004513 putative substrate binding site [chemical binding]; other site 1091500004514 catalytic Zn binding site [ion binding]; other site 1091500004515 structural Zn binding site [ion binding]; other site 1091500004516 CAAX protease self-immunity; Region: Abi; pfam02517 1091500004517 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 1091500004518 MOSC domain; Region: MOSC; pfam03473 1091500004519 short chain dehydrogenase; Provisional; Region: PRK07825 1091500004520 classical (c) SDRs; Region: SDR_c; cd05233 1091500004521 NAD(P) binding site [chemical binding]; other site 1091500004522 active site 1091500004523 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1091500004524 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1091500004525 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1091500004526 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1091500004527 potential frameshift: common BLAST hit: gi|253799089|ref|YP_003032090.1| acetyl-CoA acetyltransferase 1091500004528 hypothetical protein; Provisional; Region: PRK12320 1091500004529 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1091500004530 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 1091500004531 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1091500004532 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1091500004533 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1091500004534 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 1091500004535 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 1091500004536 active site 1091500004537 substrate binding site [chemical binding]; other site 1091500004538 FMN binding site [chemical binding]; other site 1091500004539 putative catalytic residues [active] 1091500004540 Uncharacterized conserved protein [Function unknown]; Region: COG5579 1091500004541 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1091500004542 Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906 1091500004543 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 1091500004544 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 1091500004545 heme binding site [chemical binding]; other site 1091500004546 ferroxidase pore; other site 1091500004547 ferroxidase diiron center [ion binding]; other site 1091500004548 potential frameshift: common BLAST hit: gi|340626885|ref|YP_004745337.1| putative integral membrane protein 1091500004549 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1091500004550 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1091500004551 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 1091500004552 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1091500004553 Cytochrome P450; Region: p450; cl12078 1091500004554 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 1091500004555 short chain dehydrogenase; Provisional; Region: PRK08267 1091500004556 classical (c) SDR, subgroup 9; Region: SDR_c9; cd08931 1091500004557 putative NAD(P) binding site [chemical binding]; other site 1091500004558 active site 1091500004559 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1091500004560 hydrophobic ligand binding site; other site 1091500004561 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1091500004562 chorismate mutase; Provisional; Region: PRK09269 1091500004563 chorismate mutase, putative; Region: CM_mono2; TIGR01806 1091500004564 potential frameshift: common BLAST hit: gi|15841356|ref|NP_336393.1| esterase, , antigen 85-B 1091500004565 Leucine carboxyl methyltransferase; Region: LCM; cl01306 1091500004566 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1091500004567 Leucine carboxyl methyltransferase; Region: LCM; cl01306 1091500004568 Uncharacterized conserved protein [Function unknown]; Region: COG2353 1091500004569 potential frameshift: common BLAST hit: gi|253799059|ref|YP_003032060.1| dehydrogenase 1091500004570 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1091500004571 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1091500004572 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1091500004573 putative active site [active] 1091500004574 dimerization interface [polypeptide binding]; other site 1091500004575 putative tRNAtyr binding site [nucleotide binding]; other site 1091500004576 Domain of unknown function DUF77; Region: DUF77; pfam01910 1091500004577 Macro domain, Unknown family 2. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_2; cd03330 1091500004578 putative ADP-ribose binding site [chemical binding]; other site 1091500004579 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1091500004580 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1091500004581 cyclase homology domain; Region: CHD; cd07302 1091500004582 nucleotidyl binding site; other site 1091500004583 metal binding site [ion binding]; metal-binding site 1091500004584 dimer interface [polypeptide binding]; other site 1091500004585 competence damage-inducible protein A; Provisional; Region: PRK00549 1091500004586 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1091500004587 putative MPT binding site; other site 1091500004588 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 1091500004589 putative sialic acid transporter; Region: 2A0112; TIGR00891 1091500004590 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1091500004591 putative substrate translocation pore; other site 1091500004592 Predicted membrane protein [Function unknown]; Region: COG1950 1091500004593 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1091500004594 anti sigma factor interaction site; other site 1091500004595 regulatory phosphorylation site [posttranslational modification]; other site 1091500004596 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1091500004597 Domain of unknown function (DUF4262); Region: DUF4262; pfam14081 1091500004598 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 1091500004599 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 1091500004600 dimer interface [polypeptide binding]; other site 1091500004601 active site 1091500004602 heme binding site [chemical binding]; other site 1091500004603 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 1091500004604 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1091500004605 metal binding site 2 [ion binding]; metal-binding site 1091500004606 putative DNA binding helix; other site 1091500004607 metal binding site 1 [ion binding]; metal-binding site 1091500004608 dimer interface [polypeptide binding]; other site 1091500004609 structural Zn2+ binding site [ion binding]; other site 1091500004610 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1091500004611 substrate binding site [chemical binding]; other site 1091500004612 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1091500004613 substrate binding site [chemical binding]; other site 1091500004614 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1091500004615 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR3; cd08275 1091500004616 putative NAD(P) binding site [chemical binding]; other site 1091500004617 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1091500004618 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1091500004619 tetramer interface [polypeptide binding]; other site 1091500004620 active site 1091500004621 Mg2+/Mn2+ binding site [ion binding]; other site 1091500004622 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435 1091500004623 potential frameshift: common BLAST hit: gi|148661725|ref|YP_001283248.1| PPE family protein 1091500004624 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1091500004625 PPE family; Region: PPE; pfam00823 1091500004626 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1091500004627 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1091500004628 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 1091500004629 putative hydrophobic ligand binding site [chemical binding]; other site 1091500004630 protein interface [polypeptide binding]; other site 1091500004631 gate; other site 1091500004632 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1091500004633 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 1091500004634 putative acyl-acceptor binding pocket; other site 1091500004635 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1091500004636 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1091500004637 Beta-lactamase; Region: Beta-lactamase; pfam00144 1091500004638 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1091500004639 Beta-lactamase; Region: Beta-lactamase; pfam00144 1091500004640 potential frameshift: common BLAST hit: gi|339631978|ref|YP_004723620.1| acyl-CoA ligase 1091500004641 Domain of unknown function (DUF1942); Region: DUF1942; pfam09167 1091500004642 short chain dehydrogenase; Provisional; Region: PRK05867 1091500004643 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1091500004644 NAD(P) binding site [chemical binding]; other site 1091500004645 active site 1091500004646 TIGR03085 family protein; Region: TIGR03085 1091500004647 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1091500004648 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1091500004649 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 1091500004650 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1091500004651 conserved cys residue [active] 1091500004652 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1091500004653 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1091500004654 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1091500004655 dimer interface [polypeptide binding]; other site 1091500004656 catalytic triad [active] 1091500004657 peroxidatic and resolving cysteines [active] 1091500004658 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1091500004659 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1091500004660 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1091500004661 active site 1091500004662 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1091500004663 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 1091500004664 FAD binding site [chemical binding]; other site 1091500004665 substrate binding site [chemical binding]; other site 1091500004666 catalytic base [active] 1091500004667 enoyl-CoA hydratase; Provisional; Region: PRK08290 1091500004668 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1091500004669 substrate binding site [chemical binding]; other site 1091500004670 oxyanion hole (OAH) forming residues; other site 1091500004671 trimer interface [polypeptide binding]; other site 1091500004672 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1091500004673 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1091500004674 potential frameshift: common BLAST hit: gi|253799016|ref|YP_003032017.1| oxygenase 1091500004675 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1091500004676 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1091500004677 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1091500004678 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 1091500004679 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1091500004680 GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807 1091500004681 dimerization interface [polypeptide binding]; other site 1091500004682 active site 1091500004683 classical (c) SDR, subgroup 12; Region: SDR_c12; cd08944 1091500004684 putative NAD(P) binding site [chemical binding]; other site 1091500004685 active site 1091500004686 homodimer interface [polypeptide binding]; other site 1091500004687 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 1091500004688 SEC-C motif; Region: SEC-C; pfam02810 1091500004689 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 1091500004690 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: VapC; COG1487 1091500004691 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 1091500004692 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1091500004693 non-specific DNA binding site [nucleotide binding]; other site 1091500004694 salt bridge; other site 1091500004695 sequence-specific DNA binding site [nucleotide binding]; other site 1091500004696 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 1091500004697 Uncharacterized protein family (UPF0156); Region: RHH_2; pfam03693 1091500004698 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 1091500004699 putative active site [active] 1091500004700 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1091500004701 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1091500004702 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1091500004703 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1091500004704 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1091500004705 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1091500004706 Permease; Region: Permease; pfam02405 1091500004707 potential frameshift: common BLAST hit: gi|148823179|ref|YP_001287933.1| integral membrane protein YrbE3b 1091500004708 potential frameshift: common BLAST hit: gi|253798986|ref|YP_003031987.1| MCE-family protein mce3A 1091500004709 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1091500004710 mce related protein; Region: MCE; pfam02470 1091500004711 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1091500004712 mce related protein; Region: MCE; pfam02470 1091500004713 potential frameshift: common BLAST hit: gi|148823183|ref|YP_001287937.1| MCE-family protein mce3D 1091500004714 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1091500004715 mce related protein; Region: MCE; pfam02470 1091500004716 potential frameshift: common BLAST hit: gi|340626980|ref|YP_004745432.1| MCE-family protein MCE3F 1091500004717 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1091500004718 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1091500004719 YacP-like NYN domain; Region: NYN_YacP; cl01491 1091500004720 Peptidase family M48; Region: Peptidase_M48; pfam01435 1091500004721 Methyltransferase domain; Region: Methyltransf_18; pfam12847 1091500004722 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1091500004723 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1091500004724 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1091500004725 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1091500004726 dimer interface [polypeptide binding]; other site 1091500004727 putative radical transfer pathway; other site 1091500004728 diiron center [ion binding]; other site 1091500004729 tyrosyl radical; other site 1091500004730 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 1091500004731 putative active site [active] 1091500004732 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4423 1091500004733 potential frameshift: common BLAST hit: gi|339632021|ref|YP_004723663.1| PE-PGRS family protein 1091500004734 Cutinase; Region: Cutinase; pfam01083 1091500004735 Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594 1091500004736 transcriptional regulator, ArgP family; Region: argP; TIGR03298 1091500004737 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1091500004738 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1091500004739 dimerization interface [polypeptide binding]; other site 1091500004740 Lysine efflux permease [General function prediction only]; Region: COG1279 1091500004741 Cellulose binding domain; Region: CBM_2; pfam00553 1091500004742 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091500004743 S-adenosylmethionine binding site [chemical binding]; other site 1091500004744 Uncharacterized conserved protein [Function unknown]; Region: COG5654 1091500004745 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 1091500004746 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 1091500004747 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1091500004748 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 1091500004749 potential frameshift: common BLAST hit: gi|339632031|ref|YP_004723673.1| ATPase P 1091500004750 potential frameshift: common BLAST hit: gi|339632031|ref|YP_004723673.1| ATPase P 1091500004751 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 1091500004752 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1091500004753 dimerization interface [polypeptide binding]; other site 1091500004754 putative DNA binding site [nucleotide binding]; other site 1091500004755 putative Zn2+ binding site [ion binding]; other site 1091500004756 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1091500004757 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1091500004758 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1091500004759 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1091500004760 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1091500004761 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1091500004762 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1091500004763 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1091500004764 tetramer interface [polypeptide binding]; other site 1091500004765 active site 1091500004766 Mg2+/Mn2+ binding site [ion binding]; other site 1091500004767 potential frameshift: common BLAST hit: gi|224990377|ref|YP_002645064.1| integral membrane protein 1091500004768 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1091500004769 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 1091500004770 3beta17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 3beta-17beta-HSD_like_SDR_c; cd05341 1091500004771 homotetramer interface [polypeptide binding]; other site 1091500004772 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1091500004773 NAD binding site [chemical binding]; other site 1091500004774 homodimer interface [polypeptide binding]; other site 1091500004775 active site 1091500004776 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1091500004777 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091500004778 S-adenosylmethionine binding site [chemical binding]; other site 1091500004779 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 1091500004780 Predicted kinase [General function prediction only]; Region: COG0645 1091500004781 AAA domain; Region: AAA_17; pfam13207 1091500004782 Universal stress protein family; Region: Usp; pfam00582 1091500004783 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1091500004784 Ligand Binding Site [chemical binding]; other site 1091500004785 potential frameshift: common BLAST hit: gi|148823221|ref|YP_001287975.1| trehalose-6-phosphate phosphatase otsB1 1091500004786 Ferredoxin [Energy production and conversion]; Region: COG1146 1091500004787 AAA domain; Region: AAA_14; pfam13173 1091500004788 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 1091500004789 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 1091500004790 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 1091500004791 putative active site [active] 1091500004792 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1091500004793 MarR family; Region: MarR_2; pfam12802 1091500004794 Phage envelope protein [General function prediction only]; Region: COG5562 1091500004795 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1091500004796 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1091500004797 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1091500004798 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1091500004799 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1091500004800 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1091500004801 active site 1091500004802 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1091500004803 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1091500004804 non-specific DNA binding site [nucleotide binding]; other site 1091500004805 salt bridge; other site 1091500004806 sequence-specific DNA binding site [nucleotide binding]; other site 1091500004807 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 1091500004808 Uncharacterized conserved protein [Function unknown]; Region: COG2442 1091500004809 Predicted helicase [General function prediction only]; Region: COG4889 1091500004810 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1091500004811 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1091500004812 non-specific DNA binding site [nucleotide binding]; other site 1091500004813 salt bridge; other site 1091500004814 sequence-specific DNA binding site [nucleotide binding]; other site 1091500004815 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4683 1091500004816 potential frameshift: common BLAST hit: gi|253798919|ref|YP_003031920.1| helicase 1091500004817 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1091500004818 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1091500004819 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1091500004820 Ligand Binding Site [chemical binding]; other site 1091500004821 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1091500004822 Ligand Binding Site [chemical binding]; other site 1091500004823 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1091500004824 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1091500004825 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1091500004826 Histidine kinase; Region: HisKA_3; pfam07730 1091500004827 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1091500004828 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1091500004829 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1091500004830 putative substrate binding site [chemical binding]; other site 1091500004831 putative ATP binding site [chemical binding]; other site 1091500004832 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1091500004833 active site 1091500004834 Erythromycin esterase homolog [General function prediction only]; Region: COG2312 1091500004835 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1091500004836 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1091500004837 putative dimer interface [polypeptide binding]; other site 1091500004838 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1091500004839 dimer interface [polypeptide binding]; other site 1091500004840 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 1091500004841 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1091500004842 putative DNA binding site [nucleotide binding]; other site 1091500004843 dimerization interface [polypeptide binding]; other site 1091500004844 putative Zn2+ binding site [ion binding]; other site 1091500004845 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1091500004846 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1091500004847 MDMPI C-terminal domain; Region: MDMPI_C; pfam07398 1091500004848 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1091500004849 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 1091500004850 nucleophile elbow; other site 1091500004851 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1091500004852 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1091500004853 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1091500004854 Walker A/P-loop; other site 1091500004855 ATP binding site [chemical binding]; other site 1091500004856 Q-loop/lid; other site 1091500004857 ABC transporter signature motif; other site 1091500004858 Walker B; other site 1091500004859 D-loop; other site 1091500004860 H-loop/switch region; other site 1091500004861 TOBE domain; Region: TOBE_2; pfam08402 1091500004862 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1091500004863 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1091500004864 dimer interface [polypeptide binding]; other site 1091500004865 conserved gate region; other site 1091500004866 putative PBP binding loops; other site 1091500004867 ABC-ATPase subunit interface; other site 1091500004868 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1091500004869 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1091500004870 dimer interface [polypeptide binding]; other site 1091500004871 conserved gate region; other site 1091500004872 putative PBP binding loops; other site 1091500004873 ABC-ATPase subunit interface; other site 1091500004874 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1091500004875 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1091500004876 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 1091500004877 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 1091500004878 Isochorismatase family; Region: Isochorismatase; pfam00857 1091500004879 catalytic triad [active] 1091500004880 metal binding site [ion binding]; metal-binding site 1091500004881 conserved cis-peptide bond; other site 1091500004882 Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861 1091500004883 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1091500004884 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1091500004885 substrate binding pocket [chemical binding]; other site 1091500004886 catalytic triad [active] 1091500004887 potential frameshift: common BLAST hit: gi|339632088|ref|YP_004723730.1| polyketide synthase 1091500004888 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 1091500004889 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 1091500004890 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1091500004891 putative active site [active] 1091500004892 catalytic triad [active] 1091500004893 putative dimer interface [polypeptide binding]; other site 1091500004894 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 1091500004895 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 1091500004896 Ligand binding site; other site 1091500004897 Putative Catalytic site; other site 1091500004898 DXD motif; other site 1091500004899 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 1091500004900 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1091500004901 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 1091500004902 30S ribosomal protein S18; Provisional; Region: PRK13401 1091500004903 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1091500004904 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1091500004905 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1091500004906 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1091500004907 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1091500004908 intersubunit interface [polypeptide binding]; other site 1091500004909 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 1091500004910 PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666 1091500004911 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 1091500004912 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1091500004913 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1091500004914 PemK-like protein; Region: PemK; pfam02452 1091500004915 potential frameshift: common BLAST hit: gi|339632104|ref|YP_004723746.1| cobalamin biosynthesis protein CobG 1091500004916 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 1091500004917 Precorrin-8X methylmutase; Region: CbiC; pfam02570 1091500004918 potential frameshift: common BLAST hit: gi|339632106|ref|YP_004723748.1| bifunctional protein, CobI-CobJ fusion protein: 1091500004919 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1091500004920 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091500004921 S-adenosylmethionine binding site [chemical binding]; other site 1091500004922 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 1091500004923 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1091500004924 RNA polymerase sigma factor SigC; Reviewed; Region: PRK09649 1091500004925 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1091500004926 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1091500004927 DNA binding residues [nucleotide binding] 1091500004928 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 1091500004929 precorrin-6x reductase; Region: precor6x_red; TIGR00715 1091500004930 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 1091500004931 active site 1091500004932 SAM binding site [chemical binding]; other site 1091500004933 homodimer interface [polypeptide binding]; other site 1091500004934 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 1091500004935 active site 1091500004936 putative homodimer interface [polypeptide binding]; other site 1091500004937 SAM binding site [chemical binding]; other site 1091500004938 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 1091500004939 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1091500004940 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1091500004941 NAD(P) binding site [chemical binding]; other site 1091500004942 active site 1091500004943 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1091500004944 Catalytic domain of uncharacterized Mycobacterium tuberculosis Rv2075c-like proteins; Region: PI-PLCc_Rv2075c_like; cd08590 1091500004945 putative active site [active] 1091500004946 catalytic site [active] 1091500004947 putative metal binding site [ion binding]; other site 1091500004948 C-type lectin (CTL)/C-type lectin-like (CTLD) domain; Region: CLECT; cl02432 1091500004949 Protein of unknown function (DUF2563); Region: DUF2563; pfam10817 1091500004950 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 1091500004951 putative transposase OrfB; Reviewed; Region: PHA02517 1091500004952 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1091500004953 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1091500004954 active site 1091500004955 ATP binding site [chemical binding]; other site 1091500004956 substrate binding site [chemical binding]; other site 1091500004957 activation loop (A-loop); other site 1091500004958 PknH-like extracellular domain; Region: PknH_C; pfam14032 1091500004959 potential frameshift: common BLAST hit: gi|340627102|ref|YP_004745554.1| putative dipeptidase PepE 1091500004960 5'-3' exonuclease, N-terminal resolvase-like domain; Region: 5_3_exonuc_N; pfam02739 1091500004961 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1091500004962 active site 1091500004963 metal binding site 1 [ion binding]; metal-binding site 1091500004964 putative 5' ssDNA interaction site; other site 1091500004965 metal binding site 3; metal-binding site 1091500004966 metal binding site 2 [ion binding]; metal-binding site 1091500004967 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1091500004968 putative DNA binding site [nucleotide binding]; other site 1091500004969 putative metal binding site [ion binding]; other site 1091500004970 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 1091500004971 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 1091500004972 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1091500004973 ATP binding site [chemical binding]; other site 1091500004974 putative Mg++ binding site [ion binding]; other site 1091500004975 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1091500004976 nucleotide binding region [chemical binding]; other site 1091500004977 ATP-binding site [chemical binding]; other site 1091500004978 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 1091500004979 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 1091500004980 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 1091500004981 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 1091500004982 Predicted transcriptional regulator [Transcription]; Region: COG2378 1091500004983 WYL domain; Region: WYL; pfam13280 1091500004984 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 1091500004985 PE family; Region: PE; pfam00934 1091500004986 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 1091500004987 SNF2 Helicase protein; Region: DUF3670; pfam12419 1091500004988 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1091500004989 ATP binding site [chemical binding]; other site 1091500004990 putative Mg++ binding site [ion binding]; other site 1091500004991 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1091500004992 nucleotide binding region [chemical binding]; other site 1091500004993 ATP-binding site [chemical binding]; other site 1091500004994 Uncharacterized conserved protein [Function unknown]; Region: COG4279 1091500004995 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 1091500004996 putative active site [active] 1091500004997 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1091500004998 Transposase; Region: HTH_Tnp_1; cl17663 1091500004999 putative transposase OrfB; Reviewed; Region: PHA02517 1091500005000 HTH-like domain; Region: HTH_21; pfam13276 1091500005001 Integrase core domain; Region: rve; pfam00665 1091500005002 Integrase core domain; Region: rve_3; pfam13683 1091500005003 PE family; Region: PE; pfam00934 1091500005004 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1091500005005 PPE family; Region: PPE; pfam00823 1091500005006 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 1091500005007 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 1091500005008 active site 1091500005009 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 1091500005010 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 1091500005011 active site 1091500005012 Pup-like protein; Region: Pup; pfam05639 1091500005013 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 1091500005014 proteasome ATPase; Region: pup_AAA; TIGR03689 1091500005015 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1091500005016 Walker B motif; other site 1091500005017 arginine finger; other site 1091500005018 potential frameshift: common BLAST hit: gi|224990492|ref|YP_002645179.1| lipoprotein 1091500005019 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1550 1091500005020 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 1091500005021 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091500005022 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 1091500005023 Predicted membrane protein [Function unknown]; Region: COG3918 1091500005024 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 1091500005025 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 1091500005026 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 1091500005027 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 1091500005028 homodimer interface [polypeptide binding]; other site 1091500005029 putative metal binding site [ion binding]; other site 1091500005030 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1091500005031 PPE family; Region: PPE; pfam00823 1091500005032 potential frameshift: common BLAST hit: gi|340627133|ref|YP_004745585.1| putative 5-methyltetrahydrofolate--homocystein methyltransferase MetH 1091500005033 PAC2 family; Region: PAC2; pfam09754 1091500005034 potential frameshift: common BLAST hit: gi|253798810|ref|YP_003031811.1| L-asparagine permease ansP1 1091500005035 short chain dehydrogenase; Provisional; Region: PRK05872 1091500005036 classical (c) SDRs; Region: SDR_c; cd05233 1091500005037 NAD(P) binding site [chemical binding]; other site 1091500005038 active site 1091500005039 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1091500005040 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 1091500005041 active site 1091500005042 HIGH motif; other site 1091500005043 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1091500005044 active site 1091500005045 KMSKS motif; other site 1091500005046 Anticodon-binding domain of cysteinyl tRNA synthetases and domain found in MshC; Region: Anticodon_Ia_Cys_like; cd07955 1091500005047 putative tRNA binding surface [nucleotide binding]; other site 1091500005048 potential frameshift: common BLAST hit: gi|340627140|ref|YP_004745592.1| putative monophosphatase CYSQ 1091500005049 potential frameshift: common BLAST hit: gi|340627140|ref|YP_004745592.1| putative monophosphatase CYSQ 1091500005050 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1091500005051 conserved hypothetical protein; Region: TIGR03847 1091500005052 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1091500005053 catalytic core [active] 1091500005054 undecaprenyl-diphosphatase UppP; Region: undec_PP_bacA; TIGR00753 1091500005055 potential frameshift: common BLAST hit: gi|339632171|ref|YP_004723813.1| dihydroorotate dehydrogenase 1091500005056 hypothetical protein; Provisional; Region: PRK07906 1091500005057 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 1091500005058 putative metal binding site [ion binding]; other site 1091500005059 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483 1091500005060 Putative addiction module component; Region: Unstab_antitox; cl09921 1091500005061 DivIVA domain; Region: DivI1A_domain; TIGR03544 1091500005062 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 1091500005063 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1091500005064 YGGT family; Region: YGGT; cl00508 1091500005065 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 1091500005066 Predicted enzyme with a TIM-barrel fold [General function prediction only]; Region: COG0325 1091500005067 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1091500005068 catalytic residue [active] 1091500005069 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1091500005070 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 1091500005071 potential frameshift: common BLAST hit: gi|340627158|ref|YP_004745610.1| cell division protein FtsZ 1091500005072 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 1091500005073 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1091500005074 Cell division protein FtsQ; Region: FtsQ; pfam03799 1091500005075 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1091500005076 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1091500005077 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1091500005078 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1091500005079 potential frameshift: common BLAST hit: gi|224990529|ref|YP_002645216.1| UDP diphospho-muramoyl pentapeptide beta-N acetylglucosaminyl 1091500005080 cell division protein FtsW; Region: ftsW; TIGR02614 1091500005081 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03369 1091500005082 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1091500005083 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1091500005084 phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445 1091500005085 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1091500005086 Mg++ binding site [ion binding]; other site 1091500005087 putative catalytic motif [active] 1091500005088 putative substrate binding site [chemical binding]; other site 1091500005089 potential frameshift: common BLAST hit: gi|339632189|ref|YP_004723831.1| UDP-N-acetylmuramoylalanyl-D-glutamyl-2 1091500005090 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1091500005091 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1091500005092 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1091500005093 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1091500005094 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1091500005095 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1091500005096 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1091500005097 PE family; Region: PE; pfam00934 1091500005098 potential frameshift: common BLAST hit: gi|339632194|ref|YP_004723836.1| penicillin-binding membrane protein pbpB 1091500005099 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 1091500005100 MraW methylase family; Region: Methyltransf_5; pfam01795 1091500005101 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 1091500005102 MraZ protein; Region: MraZ; pfam02381 1091500005103 MraZ protein; Region: MraZ; pfam02381 1091500005104 putative transposase OrfB; Reviewed; Region: PHA02517 1091500005105 HTH-like domain; Region: HTH_21; pfam13276 1091500005106 Integrase core domain; Region: rve; pfam00665 1091500005107 Integrase core domain; Region: rve_3; pfam13683 1091500005108 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1091500005109 Transposase; Region: HTH_Tnp_1; cl17663 1091500005110 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 1091500005111 Protein of unknown function (DUF3153); Region: DUF3153; pfam11353 1091500005112 potential frameshift: common BLAST hit: gi|253798764|ref|YP_003031765.1| geranylgeranyl pyrophosphate synthetase idsA2 1091500005113 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 1091500005114 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1091500005115 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1091500005116 active site 1091500005117 ATP binding site [chemical binding]; other site 1091500005118 substrate binding site [chemical binding]; other site 1091500005119 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1091500005120 substrate binding site [chemical binding]; other site 1091500005121 activation loop (A-loop); other site 1091500005122 activation loop (A-loop); other site 1091500005123 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1091500005124 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1091500005125 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 1091500005126 potential frameshift: common BLAST hit: gi|340627186|ref|YP_004745638.1| putative integral membrane protein 1091500005127 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1091500005128 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1091500005129 putative acyl-acceptor binding pocket; other site 1091500005130 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 1091500005131 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1091500005132 DTAP/Switch II; other site 1091500005133 Switch I; other site 1091500005134 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1091500005135 putative hydrophobic ligand binding site [chemical binding]; other site 1091500005136 potential frameshift: common BLAST hit: gi|253798749|ref|YP_003031750.1| long-chain fatty-acid-CoA ligase fadD15 1091500005137 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1091500005138 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1091500005139 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 1091500005140 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1091500005141 NlpC/P60 family; Region: NLPC_P60; pfam00877 1091500005142 hypothetical protein; Validated; Region: PRK07883 1091500005143 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1091500005144 active site 1091500005145 substrate binding site [chemical binding]; other site 1091500005146 catalytic site [active] 1091500005147 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1091500005148 GIY-YIG motif/motif A; other site 1091500005149 active site 1091500005150 catalytic site [active] 1091500005151 putative DNA binding site [nucleotide binding]; other site 1091500005152 metal binding site [ion binding]; metal-binding site 1091500005153 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1091500005154 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1091500005155 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1091500005156 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 1091500005157 Subunit I/III interface [polypeptide binding]; other site 1091500005158 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1091500005159 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1091500005160 iron-sulfur cluster [ion binding]; other site 1091500005161 [2Fe-2S] cluster binding site [ion binding]; other site 1091500005162 potential frameshift: common BLAST hit: gi|340627201|ref|YP_004745653.1| putative ubiquinol-cytochrome C reductase QcrB 1091500005163 Protein of unknown function (DUF2561); Region: DUF2561; pfam10812 1091500005164 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 1091500005165 potential frameshift: common BLAST hit: gi|340627205|ref|YP_004745657.1| putative transmembrane cytochrome C oxidase (subunit II) CTAC 1091500005166 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 1091500005167 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1091500005168 dimer interface [polypeptide binding]; other site 1091500005169 active site 1091500005170 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1091500005171 Ligand Binding Site [chemical binding]; other site 1091500005172 Molecular Tunnel; other site 1091500005173 potential frameshift: common BLAST hit: gi|340627207|ref|YP_004745659.1| putative carbohydrate kinase CbhK 1091500005174 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1091500005175 Glycerate kinase family; Region: Gly_kinase; pfam02595 1091500005176 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 1091500005177 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 1091500005178 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 1091500005179 putative dimer interface [polypeptide binding]; other site 1091500005180 active site pocket [active] 1091500005181 putative cataytic base [active] 1091500005182 Cobalamin-5-phosphate synthase; Region: CobS; pfam02654 1091500005183 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1091500005184 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1091500005185 homodimer interface [polypeptide binding]; other site 1091500005186 substrate-cofactor binding pocket; other site 1091500005187 catalytic residue [active] 1091500005188 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1091500005189 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1091500005190 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1091500005191 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1091500005192 interface (dimer of trimers) [polypeptide binding]; other site 1091500005193 Substrate-binding/catalytic site; other site 1091500005194 Zn-binding sites [ion binding]; other site 1091500005195 short chain dehydrogenase; Validated; Region: PRK05855 1091500005196 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1091500005197 classical (c) SDRs; Region: SDR_c; cd05233 1091500005198 NAD(P) binding site [chemical binding]; other site 1091500005199 active site 1091500005200 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 1091500005201 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1091500005202 E3 interaction surface; other site 1091500005203 lipoyl attachment site [posttranslational modification]; other site 1091500005204 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1091500005205 E3 interaction surface; other site 1091500005206 lipoyl attachment site [posttranslational modification]; other site 1091500005207 e3 binding domain; Region: E3_binding; pfam02817 1091500005208 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1091500005209 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 1091500005210 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 1091500005211 putative NAD(P) binding site [chemical binding]; other site 1091500005212 putative active site [active] 1091500005213 lipoate-protein ligase B; Provisional; Region: PRK14345 1091500005214 lipoyl synthase; Provisional; Region: PRK05481 1091500005215 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1091500005216 FeS/SAM binding site; other site 1091500005217 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 1091500005218 RDD family; Region: RDD; pfam06271 1091500005219 potential frameshift: common BLAST hit: gi|340627226|ref|YP_004745678.1| glutamine synthetase GLNA1 1091500005220 potential frameshift: common BLAST hit: gi|340627227|ref|YP_004745679.1| glutamate-ammonia-ligase adenylyltransferase GLNE 1091500005221 potential frameshift: common BLAST hit: gi|340627227|ref|YP_004745679.1| glutamate-ammonia-ligase adenylyltransferase GLNE 1091500005222 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1091500005223 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1091500005224 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1091500005225 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1091500005226 TAP-like protein; Region: Abhydrolase_4; pfam08386 1091500005227 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1091500005228 TAP-like protein; Region: Abhydrolase_4; pfam08386 1091500005229 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1091500005230 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1091500005231 oligomerization interface [polypeptide binding]; other site 1091500005232 active site 1091500005233 metal binding site [ion binding]; metal-binding site 1091500005234 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 1091500005235 putative active site; other site 1091500005236 putative metal binding residues [ion binding]; other site 1091500005237 signature motif; other site 1091500005238 putative triphosphate binding site [ion binding]; other site 1091500005239 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 1091500005240 Uncharacterized protein conserved in bacteria (DUF2086); Region: DUF2086; cl17606 1091500005241 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3826 1091500005242 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 1091500005243 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1091500005244 RNA/DNA hybrid binding site [nucleotide binding]; other site 1091500005245 active site 1091500005246 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1091500005247 catalytic core [active] 1091500005248 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 1091500005249 Putative zinc ribbon domain; Region: DUF164; pfam02591 1091500005250 hypothetical protein; Provisional; Region: PRK07908 1091500005251 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1091500005252 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1091500005253 homodimer interface [polypeptide binding]; other site 1091500005254 catalytic residue [active] 1091500005255 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1091500005256 PIN domain nuclease, a component of toxin-antitoxin system (PIN domain) [Signal transduction mechanisms]; Region: COG3744 1091500005257 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1091500005258 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1091500005259 active site 1091500005260 motif I; other site 1091500005261 motif II; other site 1091500005262 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1091500005263 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1091500005264 active site 1091500005265 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 1091500005266 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 1091500005267 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 1091500005268 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1091500005269 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 1091500005270 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 1091500005271 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1091500005272 dimer interface [polypeptide binding]; other site 1091500005273 TPP-binding site [chemical binding]; other site 1091500005274 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1091500005275 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1091500005276 potential frameshift: common BLAST hit: gi|339632269|ref|YP_004723911.1| malonyl CoA-ACP transacylase 1091500005277 acyl carrier protein; Provisional; Region: acpP; PRK00982 1091500005278 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 1091500005279 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1091500005280 dimer interface [polypeptide binding]; other site 1091500005281 active site 1091500005282 potential frameshift: common BLAST hit: gi|340627250|ref|YP_004745702.1| 3-oxoacyl-[acyl-carrier protein] synthase 2 KASB 1091500005283 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1091500005284 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1091500005285 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1091500005286 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1091500005287 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1091500005288 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1091500005289 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1091500005290 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1091500005291 FAD binding domain; Region: FAD_binding_4; pfam01565 1091500005292 diacylglycerol kinase; Reviewed; Region: PRK11914 1091500005293 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1091500005294 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 1091500005295 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1091500005296 Beta-lactamase; Region: Beta-lactamase; pfam00144 1091500005297 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1091500005298 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091500005299 S-adenosylmethionine binding site [chemical binding]; other site 1091500005300 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 1091500005301 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1091500005302 NAD binding site [chemical binding]; other site 1091500005303 catalytic Zn binding site [ion binding]; other site 1091500005304 substrate binding site [chemical binding]; other site 1091500005305 structural Zn binding site [ion binding]; other site 1091500005306 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1091500005307 apolipoprotein N-acyltransferase; Region: lnt; TIGR00546 1091500005308 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1091500005309 putative active site [active] 1091500005310 catalytic triad [active] 1091500005311 putative dimer interface [polypeptide binding]; other site 1091500005312 short chain dehydrogenase; Provisional; Region: PRK05854 1091500005313 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 1091500005314 putative NAD(P) binding site [chemical binding]; other site 1091500005315 active site 1091500005316 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1091500005317 nucleotide binding site [chemical binding]; other site 1091500005318 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1091500005319 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1091500005320 Cytochrome P450; Region: p450; cl12078 1091500005321 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 1091500005322 potential frameshift: common BLAST hit: gi|339632293|ref|YP_004723935.1| cytochrome P450 1091500005323 Septum formation; Region: Septum_form; pfam13845 1091500005324 Protein of unknown function (DUF2695); Region: DUF2695; pfam10905 1091500005325 Domain of unknown function (DUF202); Region: DUF202; cl09954 1091500005326 Domain of unknown function (DUF202); Region: DUF202; pfam02656 1091500005327 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1091500005328 Cytochrome P450; Region: p450; cl12078 1091500005329 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial protein Rv2277c and similar proteins; Region: GDPD_Rv2277c_like; cd08580 1091500005330 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 1091500005331 putative active site [active] 1091500005332 catalytic site [active] 1091500005333 putative metal binding site [ion binding]; other site 1091500005334 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1091500005335 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1091500005336 putative transposase OrfB; Reviewed; Region: PHA02517 1091500005337 HTH-like domain; Region: HTH_21; pfam13276 1091500005338 Integrase core domain; Region: rve; pfam00665 1091500005339 Integrase core domain; Region: rve_3; pfam13683 1091500005340 potential frameshift: common BLAST hit: gi|339632302|ref|YP_004723944.1| dehydrogenase 1091500005341 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1091500005342 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1091500005343 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1091500005344 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1091500005345 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1091500005346 dimerization interface [polypeptide binding]; other site 1091500005347 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1091500005348 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1091500005349 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1091500005350 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1091500005351 potential frameshift: common BLAST hit: gi|340627291|ref|YP_004745743.1| putative integral membrane transport protein YjcE 1091500005352 CDP-diacylglycerol pyrophosphatase [Lipid metabolism]; Region: Cdh; COG2134 1091500005353 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1091500005354 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1091500005355 active site residue [active] 1091500005356 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1091500005357 active site residue [active] 1091500005358 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1091500005359 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 1091500005360 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1091500005361 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1091500005362 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1091500005363 homodimer interface [polypeptide binding]; other site 1091500005364 catalytic residue [active] 1091500005365 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3196 1091500005366 haloalkane dehalogenase; Provisional; Region: PRK00870 1091500005367 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1091500005368 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1091500005369 active site 1091500005370 catalytic tetrad [active] 1091500005371 potential frameshift: common BLAST hit: gi|340627307|ref|YP_004745759.1| putative chaperone protein 1091500005372 Cutinase; Region: Cutinase; pfam01083 1091500005373 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 1091500005374 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 1091500005375 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 1091500005376 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1091500005377 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1091500005378 Uncharacterized conserved protein [Function unknown]; Region: COG2442 1091500005379 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1091500005380 DNA binding site [nucleotide binding] 1091500005381 active site 1091500005382 Int/Topo IB signature motif; other site 1091500005383 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 1091500005384 DNA binding residues [nucleotide binding] 1091500005385 Family description; Region: UvrD_C_2; pfam13538 1091500005386 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1091500005387 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1091500005388 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1091500005389 putative PBP binding loops; other site 1091500005390 ABC-ATPase subunit interface; other site 1091500005391 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1091500005392 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1091500005393 dimer interface [polypeptide binding]; other site 1091500005394 conserved gate region; other site 1091500005395 putative PBP binding loops; other site 1091500005396 ABC-ATPase subunit interface; other site 1091500005397 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1091500005398 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1091500005399 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1091500005400 Ligand Binding Site [chemical binding]; other site 1091500005401 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1091500005402 Ligand Binding Site [chemical binding]; other site 1091500005403 amino acid transporter; Region: 2A0306; TIGR00909 1091500005404 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1091500005405 potential frameshift: common BLAST hit: gi|340627331|ref|YP_004745783.1| putative ornithine aminotransferase 1091500005406 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1091500005407 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1091500005408 Amidinotransferase; Region: Amidinotransf; pfam02274 1091500005409 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 1091500005410 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1091500005411 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1091500005412 putative DNA binding site [nucleotide binding]; other site 1091500005413 putative Zn2+ binding site [ion binding]; other site 1091500005414 AsnC family; Region: AsnC_trans_reg; pfam01037 1091500005415 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1091500005416 potential frameshift: common BLAST hit: gi|339632351|ref|YP_004723993.1| ABC transporter ATP-binding protein 1091500005417 MarR family; Region: MarR; pfam01047 1091500005418 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1091500005419 PE family; Region: PE; pfam00934 1091500005420 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1091500005421 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1091500005422 putative substrate translocation pore; other site 1091500005423 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 1091500005424 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1091500005425 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1091500005426 malate dehydrogenase; Provisional; Region: PRK13529 1091500005427 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1091500005428 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1091500005429 NAD(P) binding site [chemical binding]; other site 1091500005430 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1091500005431 putative substrate translocation pore; other site 1091500005432 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1091500005433 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1091500005434 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1091500005435 dimer interface [polypeptide binding]; other site 1091500005436 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 1091500005437 serine O-acetyltransferase; Region: cysE; TIGR01172 1091500005438 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1091500005439 trimer interface [polypeptide binding]; other site 1091500005440 active site 1091500005441 substrate binding site [chemical binding]; other site 1091500005442 CoA binding site [chemical binding]; other site 1091500005443 hypothetical protein; Provisional; Region: PRK14851 1091500005444 hypothetical protein; Validated; Region: PRK08223 1091500005445 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 1091500005446 ATP binding site [chemical binding]; other site 1091500005447 substrate interface [chemical binding]; other site 1091500005448 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1091500005449 PE family; Region: PE; pfam00934 1091500005450 DNA primase; Validated; Region: dnaG; PRK05667 1091500005451 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1091500005452 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1091500005453 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1091500005454 active site 1091500005455 metal binding site [ion binding]; metal-binding site 1091500005456 interdomain interaction site; other site 1091500005457 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1091500005458 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 1091500005459 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 1091500005460 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1091500005461 Zn2+ binding site [ion binding]; other site 1091500005462 Mg2+ binding site [ion binding]; other site 1091500005463 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1091500005464 Repair protein; Region: Repair_PSII; pfam04536 1091500005465 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1091500005466 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1091500005467 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 1091500005468 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1091500005469 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 1091500005470 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1091500005471 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 1091500005472 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1091500005473 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1091500005474 PPE family; Region: PPE; pfam00823 1091500005475 PPE family; Region: PPE; pfam00823 1091500005476 potential frameshift: common BLAST hit: gi|148823556|ref|YP_001288310.1| PPE family protein 1091500005477 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1091500005478 Transposase; Region: HTH_Tnp_1; cl17663 1091500005479 putative transposase OrfB; Reviewed; Region: PHA02517 1091500005480 HTH-like domain; Region: HTH_21; pfam13276 1091500005481 Integrase core domain; Region: rve; pfam00665 1091500005482 Integrase core domain; Region: rve_3; pfam13683 1091500005483 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1091500005484 PPE family; Region: PPE; pfam00823 1091500005485 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1091500005486 glycyl-tRNA synthetase; Provisional; Region: PRK04173 1091500005487 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1091500005488 motif 1; other site 1091500005489 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 1091500005490 active site 1091500005491 motif 2; other site 1091500005492 motif 3; other site 1091500005493 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 1091500005494 anticodon binding site; other site 1091500005495 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1091500005496 dimerization interface [polypeptide binding]; other site 1091500005497 putative DNA binding site [nucleotide binding]; other site 1091500005498 putative Zn2+ binding site [ion binding]; other site 1091500005499 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1091500005500 metal binding site 2 [ion binding]; metal-binding site 1091500005501 putative DNA binding helix; other site 1091500005502 metal binding site 1 [ion binding]; metal-binding site 1091500005503 dimer interface [polypeptide binding]; other site 1091500005504 structural Zn2+ binding site [ion binding]; other site 1091500005505 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1091500005506 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1091500005507 catalytic residue [active] 1091500005508 putative FPP diphosphate binding site; other site 1091500005509 putative FPP binding hydrophobic cleft; other site 1091500005510 dimer interface [polypeptide binding]; other site 1091500005511 putative IPP diphosphate binding site; other site 1091500005512 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1091500005513 Recombination protein O N terminal; Region: RecO_N; pfam11967 1091500005514 Recombination protein O C terminal; Region: RecO_C; pfam02565 1091500005515 potential frameshift: common BLAST hit: gi|340627374|ref|YP_004745826.1| putative amidase AMIA2 1091500005516 GTPase Era; Reviewed; Region: era; PRK00089 1091500005517 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1091500005518 G1 box; other site 1091500005519 GTP/Mg2+ binding site [chemical binding]; other site 1091500005520 Switch I region; other site 1091500005521 G2 box; other site 1091500005522 Switch II region; other site 1091500005523 G3 box; other site 1091500005524 G4 box; other site 1091500005525 G5 box; other site 1091500005526 KH domain; Region: KH_2; pfam07650 1091500005527 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1091500005528 Domain of unknown function DUF21; Region: DUF21; pfam01595 1091500005529 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1091500005530 Transporter associated domain; Region: CorC_HlyC; smart01091 1091500005531 metal-binding heat shock protein; Provisional; Region: PRK00016 1091500005532 K homology RNA-binding domain; Region: KH; smart00322 1091500005533 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1091500005534 PhoH-like protein; Region: PhoH; pfam02562 1091500005535 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1091500005536 PE family; Region: PE; pfam00934 1091500005537 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 1091500005538 RNA methyltransferase, RsmE family; Region: TIGR00046 1091500005539 chaperone protein DnaJ; Provisional; Region: PRK14278 1091500005540 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1091500005541 HSP70 interaction site [polypeptide binding]; other site 1091500005542 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1091500005543 Zn binding sites [ion binding]; other site 1091500005544 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1091500005545 dimer interface [polypeptide binding]; other site 1091500005546 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1091500005547 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 1091500005548 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 1091500005549 potential frameshift: common BLAST hit: gi|339632404|ref|YP_004724046.1| lysine-N-oxygenase 1091500005550 potential frameshift: common BLAST hit: gi|339632405|ref|YP_004724047.1| peptide synthetase 1091500005551 potential frameshift: common BLAST hit: gi|339632405|ref|YP_004724047.1| peptide synthetase 1091500005552 potential frameshift: common BLAST hit: gi|339632405|ref|YP_004724047.1| peptide synthetase 1091500005553 potential frameshift: common BLAST hit: gi|345462009|ref|NP_216896.2| peptide synthetase 1091500005554 potential frameshift: common BLAST hit: gi|339632407|ref|YP_004724049.1| polyketide synthetase 1091500005555 potential frameshift: common BLAST hit: gi|339632407|ref|YP_004724049.1| polyketide synthetase 1091500005556 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1091500005557 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1091500005558 active site 1091500005559 potential frameshift: common BLAST hit: gi|253798540|ref|YP_003031541.1| phenyloxazoline synthase mbtB 1091500005560 potential frameshift: common BLAST hit: gi|253798540|ref|YP_003031541.1| phenyloxazoline synthase mbtB 1091500005561 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 1091500005562 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 1091500005563 acyl-activating enzyme (AAE) consensus motif; other site 1091500005564 active site 1091500005565 AMP binding site [chemical binding]; other site 1091500005566 substrate binding site [chemical binding]; other site 1091500005567 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1091500005568 salicylate synthase MbtI; Reviewed; Region: PRK07912 1091500005569 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1091500005570 potential frameshift: common BLAST hit: gi|253798535|ref|YP_003031536.1| coproporphyrinogen III oxidase 1091500005571 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1091500005572 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 1091500005573 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1091500005574 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1091500005575 potential frameshift: common BLAST hit: gi|340627401|ref|YP_004745853.1| putative 3'-phosphoadenosine 5'-phosphosulfate reductase CYSH 1091500005576 potential frameshift: common BLAST hit: gi|340627402|ref|YP_004745854.1| cobalamin (vitamin b12) biosynthesis cbix protein 1091500005577 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1091500005578 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1091500005579 Predicted membrane protein [Function unknown]; Region: COG1297 1091500005580 putative oligopeptide transporter, OPT family; Region: TIGR00733 1091500005581 PE family; Region: PE; pfam00934 1091500005582 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 1091500005583 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 1091500005584 Walker A/P-loop; other site 1091500005585 ATP binding site [chemical binding]; other site 1091500005586 Q-loop/lid; other site 1091500005587 ABC transporter signature motif; other site 1091500005588 Walker B; other site 1091500005589 D-loop; other site 1091500005590 H-loop/switch region; other site 1091500005591 sulfate transport protein; Provisional; Region: cysT; CHL00187 1091500005592 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1091500005593 dimer interface [polypeptide binding]; other site 1091500005594 conserved gate region; other site 1091500005595 putative PBP binding loops; other site 1091500005596 ABC-ATPase subunit interface; other site 1091500005597 potential frameshift: common BLAST hit: gi|340627408|ref|YP_004745860.1| putative sulfate-transport integral membrane protein ABC 1091500005598 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 1091500005599 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1091500005600 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 1091500005601 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1091500005602 PknH-like extracellular domain; Region: PknH_C; pfam14032 1091500005603 GTP-binding protein LepA; Provisional; Region: PRK05433 1091500005604 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1091500005605 G1 box; other site 1091500005606 putative GEF interaction site [polypeptide binding]; other site 1091500005607 GTP/Mg2+ binding site [chemical binding]; other site 1091500005608 Switch I region; other site 1091500005609 G2 box; other site 1091500005610 G3 box; other site 1091500005611 Switch II region; other site 1091500005612 G4 box; other site 1091500005613 G5 box; other site 1091500005614 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1091500005615 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1091500005616 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1091500005617 PemK-like protein; Region: PemK; pfam02452 1091500005618 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 1091500005619 FOG: CBS domain [General function prediction only]; Region: COG0517 1091500005620 ribonuclease Z; Reviewed; Region: PRK00055 1091500005621 PE family; Region: PE; pfam00934 1091500005622 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1091500005623 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1091500005624 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1091500005625 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1091500005626 hypothetical protein; Reviewed; Region: PRK07914 1091500005627 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 1091500005628 Competence protein; Region: Competence; pfam03772 1091500005629 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 1091500005630 Helix-hairpin-helix motif; Region: HHH; pfam00633 1091500005631 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 1091500005632 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1091500005633 Coenzyme A binding pocket [chemical binding]; other site 1091500005634 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307 1091500005635 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1091500005636 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1091500005637 active site 1091500005638 catalytic triad [active] 1091500005639 oxyanion hole [active] 1091500005640 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1091500005641 catalytic core [active] 1091500005642 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 1091500005643 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1091500005644 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1091500005645 active site 1091500005646 (T/H)XGH motif; other site 1091500005647 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1091500005648 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091500005649 S-adenosylmethionine binding site [chemical binding]; other site 1091500005650 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1091500005651 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1091500005652 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 1091500005653 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1091500005654 metal ion-dependent adhesion site (MIDAS); other site 1091500005655 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1091500005656 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1091500005657 Walker A motif; other site 1091500005658 ATP binding site [chemical binding]; other site 1091500005659 Walker B motif; other site 1091500005660 arginine finger; other site 1091500005661 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1091500005662 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1091500005663 putative catalytic cysteine [active] 1091500005664 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1091500005665 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1091500005666 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1091500005667 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1091500005668 dimer interface [polypeptide binding]; other site 1091500005669 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1091500005670 catalytic triad [active] 1091500005671 peroxidatic and resolving cysteines [active] 1091500005672 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 1091500005673 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 1091500005674 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1091500005675 PPE family; Region: PPE; pfam00823 1091500005676 PE family; Region: PE; pfam00934 1091500005677 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1091500005678 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1091500005679 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1091500005680 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1091500005681 ligand binding site [chemical binding]; other site 1091500005682 flexible hinge region; other site 1091500005683 potential frameshift: common BLAST hit: gi|340627448|ref|YP_004745900.1| putative cyclase 1091500005684 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1091500005685 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1091500005686 substrate binding site [chemical binding]; other site 1091500005687 dimer interface [polypeptide binding]; other site 1091500005688 ATP binding site [chemical binding]; other site 1091500005689 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1091500005690 NAD synthetase; Reviewed; Region: nadE; PRK02628 1091500005691 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 1091500005692 multimer interface [polypeptide binding]; other site 1091500005693 active site 1091500005694 catalytic triad [active] 1091500005695 protein interface 1 [polypeptide binding]; other site 1091500005696 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1091500005697 homodimer interface [polypeptide binding]; other site 1091500005698 NAD binding pocket [chemical binding]; other site 1091500005699 ATP binding pocket [chemical binding]; other site 1091500005700 Mg binding site [ion binding]; other site 1091500005701 active-site loop [active] 1091500005702 gamma-glutamyl kinase; Provisional; Region: PRK05429 1091500005703 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1091500005704 nucleotide binding site [chemical binding]; other site 1091500005705 homotetrameric interface [polypeptide binding]; other site 1091500005706 putative phosphate binding site [ion binding]; other site 1091500005707 putative allosteric binding site; other site 1091500005708 PUA domain; Region: PUA; pfam01472 1091500005709 GTPase CgtA; Reviewed; Region: obgE; PRK12296 1091500005710 GTP1/OBG; Region: GTP1_OBG; pfam01018 1091500005711 Obg GTPase; Region: Obg; cd01898 1091500005712 G1 box; other site 1091500005713 GTP/Mg2+ binding site [chemical binding]; other site 1091500005714 Switch I region; other site 1091500005715 G2 box; other site 1091500005716 G3 box; other site 1091500005717 Switch II region; other site 1091500005718 G4 box; other site 1091500005719 G5 box; other site 1091500005720 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1091500005721 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1091500005722 potential frameshift: common BLAST hit: gi|340627456|ref|YP_004745908.1| putative 50S ribosomal protein L21 RPLU 1091500005723 potential frameshift: common BLAST hit: gi|339632471|ref|YP_004724113.1| C4-dicarboxylate-transporter 1091500005724 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 1091500005725 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1091500005726 homodimer interface [polypeptide binding]; other site 1091500005727 oligonucleotide binding site [chemical binding]; other site 1091500005728 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1091500005729 active site 1091500005730 multimer interface [polypeptide binding]; other site 1091500005731 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 1091500005732 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1091500005733 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1091500005734 potential frameshift: common BLAST hit: gi|339632476|ref|YP_004724118.1| valyl-tRNA synthase 1091500005735 potential frameshift: common BLAST hit: gi|339632476|ref|YP_004724118.1| valyl-tRNA synthase 1091500005736 potential frameshift: common BLAST hit: gi|253798471|ref|YP_003031472.1| saccharopine dehydrogenase 1091500005737 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1091500005738 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1091500005739 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1091500005740 GTP binding site; other site 1091500005741 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 1091500005742 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 1091500005743 TPP-binding site [chemical binding]; other site 1091500005744 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1091500005745 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 1091500005746 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1091500005747 dimer interface [polypeptide binding]; other site 1091500005748 PYR/PP interface [polypeptide binding]; other site 1091500005749 TPP binding site [chemical binding]; other site 1091500005750 substrate binding site [chemical binding]; other site 1091500005751 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1091500005752 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1091500005753 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1091500005754 Walker A motif; other site 1091500005755 ATP binding site [chemical binding]; other site 1091500005756 Walker B motif; other site 1091500005757 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1091500005758 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 1091500005759 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 1091500005760 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1091500005761 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1091500005762 putative substrate translocation pore; other site 1091500005763 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1091500005764 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 1091500005765 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1091500005766 oligomer interface [polypeptide binding]; other site 1091500005767 active site residues [active] 1091500005768 Clp protease; Region: CLP_protease; pfam00574 1091500005769 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1091500005770 oligomer interface [polypeptide binding]; other site 1091500005771 active site residues [active] 1091500005772 potential frameshift: common BLAST hit: gi|375295722|ref|YP_005099989.1| trigger factor protein tig 1091500005773 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1091500005774 Bacterial trigger factor protein (TF); Region: Trigger_N; pfam05697 1091500005775 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1091500005776 Beta-lactamase; Region: Beta-lactamase; pfam00144 1091500005777 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1091500005778 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 1091500005779 putative DNA binding site [nucleotide binding]; other site 1091500005780 catalytic residue [active] 1091500005781 putative H2TH interface [polypeptide binding]; other site 1091500005782 putative catalytic residues [active] 1091500005783 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1091500005784 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1091500005785 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 1091500005786 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1091500005787 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1091500005788 potential frameshift: common BLAST hit: gi|340627481|ref|YP_004745933.1| putative aminopeptidase N 1091500005789 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1091500005790 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1091500005791 active site 1091500005792 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1091500005793 apolar tunnel; other site 1091500005794 heme binding site [chemical binding]; other site 1091500005795 dimerization interface [polypeptide binding]; other site 1091500005796 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 1091500005797 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1091500005798 active site 1091500005799 catalytic site [active] 1091500005800 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1091500005801 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1091500005802 active site 1091500005803 potential frameshift: common BLAST hit: gi|253798445|ref|YP_003031446.1| NAD-dependent glutamate dehydrogenase gdh 1091500005804 potential frameshift: common BLAST hit: gi|340627490|ref|YP_004745942.1| putative NAD-dependent glutamate dehydrogenase GDH (NAD-GDH) 1091500005805 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1091500005806 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1091500005807 ABC transporter; Region: ABC_tran_2; pfam12848 1091500005808 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1091500005809 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1091500005810 dimer interface [polypeptide binding]; other site 1091500005811 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1091500005812 ssDNA binding site [nucleotide binding]; other site 1091500005813 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1091500005814 putative transposase OrfB; Reviewed; Region: PHA02517 1091500005815 HTH-like domain; Region: HTH_21; pfam13276 1091500005816 Integrase core domain; Region: rve; pfam00665 1091500005817 Integrase core domain; Region: rve_3; pfam13683 1091500005818 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1091500005819 Transposase; Region: HTH_Tnp_1; cl17663 1091500005820 glycerol-3-phosphate acyltransferase; Validated; Region: PRK03355 1091500005821 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 1091500005822 putative acyl-acceptor binding pocket; other site 1091500005823 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1091500005824 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1091500005825 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1091500005826 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1091500005827 putative acyl-acceptor binding pocket; other site 1091500005828 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1091500005829 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1091500005830 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1091500005831 enoyl-CoA hydratase; Provisional; Region: PRK05870 1091500005832 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1091500005833 substrate binding site [chemical binding]; other site 1091500005834 oxyanion hole (OAH) forming residues; other site 1091500005835 trimer interface [polypeptide binding]; other site 1091500005836 PE family; Region: PE; pfam00934 1091500005837 potential frameshift: common BLAST hit: gi|148823685|ref|YP_001288439.1| LuxR family transcriptional regulator 1091500005838 potential frameshift: common BLAST hit: gi|15842015|ref|NP_337052.1| LuxR family transcriptional regulator 1091500005839 potential frameshift: common BLAST hit: gi|15842017|ref|NP_337054.1| PE PGRS family protein 1091500005840 TIGR00725 family protein; Region: TIGR00725 1091500005841 thymidylate synthase; Provisional; Region: thyA; PRK00956 1091500005842 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 1091500005843 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1091500005844 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1091500005845 E3 interaction surface; other site 1091500005846 lipoyl attachment site [posttranslational modification]; other site 1091500005847 e3 binding domain; Region: E3_binding; pfam02817 1091500005848 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1091500005849 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1091500005850 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1091500005851 alpha subunit interface [polypeptide binding]; other site 1091500005852 TPP binding site [chemical binding]; other site 1091500005853 heterodimer interface [polypeptide binding]; other site 1091500005854 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1091500005855 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1091500005856 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1091500005857 tetramer interface [polypeptide binding]; other site 1091500005858 TPP-binding site [chemical binding]; other site 1091500005859 heterodimer interface [polypeptide binding]; other site 1091500005860 phosphorylation loop region [posttranslational modification] 1091500005861 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1091500005862 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 1091500005863 putative active site [active] 1091500005864 putative catalytic site [active] 1091500005865 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1091500005866 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1091500005867 active site 1091500005868 potential frameshift: common BLAST hit: gi|340627515|ref|YP_004745967.1| putative acetyl-/propionyl-coenzyme A carboxylase alpha chain 1091500005869 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1091500005870 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1091500005871 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1091500005872 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1091500005873 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1091500005874 potential frameshift: common BLAST hit: gi|340627519|ref|YP_004745971.1| putative fatty-acid-CoA ligase FADD35 1091500005875 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 1091500005876 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1091500005877 classical (c) SDRs; Region: SDR_c; cd05233 1091500005878 NAD(P) binding site [chemical binding]; other site 1091500005879 active site 1091500005880 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 1091500005881 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 1091500005882 catalytic site [active] 1091500005883 putative active site [active] 1091500005884 putative substrate binding site [chemical binding]; other site 1091500005885 dimer interface [polypeptide binding]; other site 1091500005886 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1091500005887 MULE transposase domain; Region: MULE; pfam10551 1091500005888 Domain of unknown function (DUF4411); Region: DUF4411; pfam14367 1091500005889 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2739; cl17893 1091500005890 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 1091500005891 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 1091500005892 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1091500005893 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1091500005894 PE family; Region: PE; pfam00934 1091500005895 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 1091500005896 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1091500005897 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1091500005898 catalytic triad [active] 1091500005899 hypothetical protein; Provisional; Region: PRK07907 1091500005900 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 1091500005901 active site 1091500005902 metal binding site [ion binding]; metal-binding site 1091500005903 dimer interface [polypeptide binding]; other site 1091500005904 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1091500005905 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1091500005906 potential frameshift: common BLAST hit: gi|253798397|ref|YP_003031398.1| fatty-acid synthase fas 1091500005907 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 1091500005908 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 1091500005909 putative active site [active] 1091500005910 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 1091500005911 Mrr N-terminal domain; Region: Mrr_N; pfam14338 1091500005912 Restriction endonuclease; Region: Mrr_cat; pfam04471 1091500005913 ERCC4 domain; Region: ERCC4; pfam02732 1091500005914 Lsr2; Region: Lsr2; pfam11774 1091500005915 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 1091500005916 putative active site [active] 1091500005917 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1091500005918 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1091500005919 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1091500005920 catalytic residue [active] 1091500005921 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1091500005922 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 1091500005923 putative RNA binding site [nucleotide binding]; other site 1091500005924 elongation factor P; Validated; Region: PRK00529 1091500005925 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1091500005926 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1091500005927 RNA binding site [nucleotide binding]; other site 1091500005928 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1091500005929 RNA binding site [nucleotide binding]; other site 1091500005930 potential frameshift: common BLAST hit: gi|339632562|ref|YP_004724204.1| cytoplasmic peptidase PEPQ 1091500005931 potential frameshift: common BLAST hit: gi|224990914|ref|YP_002645601.1| transmembrane protein 1091500005932 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1091500005933 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1091500005934 trimer interface [polypeptide binding]; other site 1091500005935 active site 1091500005936 dimer interface [polypeptide binding]; other site 1091500005937 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1091500005938 active site 1091500005939 dimer interface [polypeptide binding]; other site 1091500005940 metal binding site [ion binding]; metal-binding site 1091500005941 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1091500005942 potential frameshift: common BLAST hit: gi|339632567|ref|YP_004724209.1| chorismate synthase 1091500005943 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 1091500005944 potential frameshift: common BLAST hit: gi|224990921|ref|YP_002645608.1| lipoprotein 1091500005945 digalactosyldiacylglycerol synthase; Region: PLN02846 1091500005946 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 1091500005947 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 1091500005948 putative active site [active] 1091500005949 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1091500005950 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1091500005951 oligomeric interface; other site 1091500005952 putative active site [active] 1091500005953 homodimer interface [polypeptide binding]; other site 1091500005954 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2402 1091500005955 putative active site [active] 1091500005956 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1091500005957 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1091500005958 shikimate-5-dehydrogenase, fungal AROM-type; Region: Shik-DH-AROM; TIGR01809 1091500005959 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1091500005960 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1091500005961 NAD(P) binding site [chemical binding]; other site 1091500005962 shikimate binding site; other site 1091500005963 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1091500005964 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1091500005965 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1091500005966 motif 1; other site 1091500005967 active site 1091500005968 motif 2; other site 1091500005969 motif 3; other site 1091500005970 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1091500005971 Uncharacterized conserved protein [Function unknown]; Region: COG0432 1091500005972 recombination factor protein RarA; Reviewed; Region: PRK13342 1091500005973 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1091500005974 Walker A motif; other site 1091500005975 ATP binding site [chemical binding]; other site 1091500005976 Walker B motif; other site 1091500005977 arginine finger; other site 1091500005978 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1091500005979 potential frameshift: common BLAST hit: gi|340627577|ref|YP_004746029.1| putative proline and glycine rich transmembrane protein 1091500005980 Protein of unknown function (DUF2652); Region: DUF2652; pfam10851 1091500005981 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1091500005982 potential frameshift: common BLAST hit: gi|339632592|ref|YP_004724234.1| glutamine-transport ATP-binding protein ABC transporter GLNQ 1091500005983 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1091500005984 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1091500005985 ligand binding site [chemical binding]; other site 1091500005986 flexible hinge region; other site 1091500005987 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1091500005988 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 1091500005989 active site 1091500005990 nucleophile elbow; other site 1091500005991 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1091500005992 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1091500005993 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1091500005994 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 1091500005995 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 1091500005996 Uncharacterized conserved protein [Function unknown]; Region: COG2308 1091500005997 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 1091500005998 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 1091500005999 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307 1091500006000 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 1091500006001 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1091500006002 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1091500006003 Transglutaminase/protease-like homologues; Region: TGc; smart00460 1091500006004 Protein of unknown function (DUF419); Region: DUF419; cl15265 1091500006005 Predicted membrane protein [Function unknown]; Region: COG4129 1091500006006 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1091500006007 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1091500006008 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1091500006009 dimer interface [polypeptide binding]; other site 1091500006010 anticodon binding site; other site 1091500006011 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1091500006012 homodimer interface [polypeptide binding]; other site 1091500006013 motif 1; other site 1091500006014 active site 1091500006015 motif 2; other site 1091500006016 GAD domain; Region: GAD; pfam02938 1091500006017 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1091500006018 active site 1091500006019 motif 3; other site 1091500006020 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 1091500006021 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1091500006022 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1091500006023 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1091500006024 Predicted metalloprotease [General function prediction only]; Region: COG2321 1091500006025 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1091500006026 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 1091500006027 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1091500006028 active site 1091500006029 metal binding site [ion binding]; metal-binding site 1091500006030 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 1091500006031 haloalkane dehalogenase; Provisional; Region: PRK03592 1091500006032 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1091500006033 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1091500006034 dimer interface [polypeptide binding]; other site 1091500006035 motif 1; other site 1091500006036 active site 1091500006037 motif 2; other site 1091500006038 motif 3; other site 1091500006039 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1091500006040 anticodon binding site; other site 1091500006041 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1091500006042 potential frameshift: common BLAST hit: gi|340627599|ref|YP_004746051.1| putative peptidyl-prolyl cis-trans isomerase B 1091500006043 potential frameshift: common BLAST hit: gi|340627600|ref|YP_004746052.1| putative GTP pyrophosphokinase RELA 1091500006044 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1091500006045 active site 1091500006046 potential frameshift: common BLAST hit: gi|253798334|ref|YP_003031335.1| lipoprotein 1091500006047 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1091500006048 Protein export membrane protein; Region: SecD_SecF; pfam02355 1091500006049 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 1091500006050 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1091500006051 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05886 1091500006052 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 1091500006053 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1091500006054 inhibitor-cofactor binding pocket; inhibition site 1091500006055 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1091500006056 catalytic residue [active] 1091500006057 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1091500006058 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1091500006059 acyl-activating enzyme (AAE) consensus motif; other site 1091500006060 AMP binding site [chemical binding]; other site 1091500006061 active site 1091500006062 CoA binding site [chemical binding]; other site 1091500006063 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 1091500006064 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 1091500006065 putative NAD(P) binding site [chemical binding]; other site 1091500006066 active site 1091500006067 putative substrate binding site [chemical binding]; other site 1091500006068 PE family; Region: PE; pfam00934 1091500006069 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1091500006070 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1091500006071 Walker A motif; other site 1091500006072 ATP binding site [chemical binding]; other site 1091500006073 Walker B motif; other site 1091500006074 arginine finger; other site 1091500006075 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1091500006076 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1091500006077 RuvA N terminal domain; Region: RuvA_N; pfam01330 1091500006078 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1091500006079 active site 1091500006080 putative DNA-binding cleft [nucleotide binding]; other site 1091500006081 dimer interface [polypeptide binding]; other site 1091500006082 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1091500006083 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 1091500006084 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 1091500006085 putative active site [active] 1091500006086 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 1091500006087 Protein of unknown function DUF2617; Region: DUF2617; pfam10936 1091500006088 Domain of unknown function (DUF4247); Region: DUF4247; pfam14042 1091500006089 potential frameshift: common BLAST hit: gi|148823794|ref|YP_001288548.1| integral membrane protein 1091500006090 Predicted spermidine synthase with an N-terminal membrane domain [General function prediction only]; Region: COG4262 1091500006091 Spermine/spermidine synthase; Region: Spermine_synth; pfam01564 1091500006092 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 1091500006093 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 1091500006094 hypothetical protein; Validated; Region: PRK00110 1091500006095 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 1091500006096 predicted active site [active] 1091500006097 catalytic triad [active] 1091500006098 acyl-CoA thioesterase II; Region: tesB; TIGR00189 1091500006099 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1091500006100 active site 1091500006101 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1091500006102 catalytic triad [active] 1091500006103 dimer interface [polypeptide binding]; other site 1091500006104 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 1091500006105 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 1091500006106 active site 1091500006107 multimer interface [polypeptide binding]; other site 1091500006108 potential frameshift: common BLAST hit: gi|340627625|ref|YP_004746077.1| putative pyridoxamine 5'-phosphate oxidase PDXH 1091500006109 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1091500006110 PPE family; Region: PPE; pfam00823 1091500006111 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1091500006112 PE-PPE domain; Region: PE-PPE; pfam08237 1091500006113 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1091500006114 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1091500006115 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1091500006116 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1091500006117 putative acyl-acceptor binding pocket; other site 1091500006118 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1091500006119 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 1091500006120 nucleotide binding site/active site [active] 1091500006121 HIT family signature motif; other site 1091500006122 catalytic residue [active] 1091500006123 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 1091500006124 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1091500006125 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1091500006126 active site 1091500006127 dimer interface [polypeptide binding]; other site 1091500006128 motif 1; other site 1091500006129 motif 2; other site 1091500006130 motif 3; other site 1091500006131 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1091500006132 anticodon binding site; other site 1091500006133 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1091500006134 phosphate binding site [ion binding]; other site 1091500006135 PE family; Region: PE; pfam00934 1091500006136 Domain of unknown function (DUF1990); Region: DUF1990; cl01969 1091500006137 Predicted transcriptional regulator [Transcription]; Region: COG2345 1091500006138 Helix-turn-helix domain; Region: HTH_20; pfam12840 1091500006139 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1091500006140 Predicted transcriptional regulator [Transcription]; Region: COG2345 1091500006141 Helix-turn-helix domain; Region: HTH_20; pfam12840 1091500006142 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091500006143 S-adenosylmethionine binding site [chemical binding]; other site 1091500006144 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1091500006145 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1091500006146 Ligand Binding Site [chemical binding]; other site 1091500006147 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1091500006148 Ligand Binding Site [chemical binding]; other site 1091500006149 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1091500006150 Ligand Binding Site [chemical binding]; other site 1091500006151 Universal stress protein family; Region: Usp; pfam00582 1091500006152 Ligand Binding Site [chemical binding]; other site 1091500006153 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 1091500006154 active site 1091500006155 Peptidase family M50; Region: Peptidase_M50; pfam02163 1091500006156 putative substrate binding region [chemical binding]; other site 1091500006157 FOG: CBS domain [General function prediction only]; Region: COG0517 1091500006158 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612 1091500006159 FOG: CBS domain [General function prediction only]; Region: COG0517 1091500006160 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 1091500006161 peptide chain release factor 1; Provisional; Region: PRK04011 1091500006162 Archease protein family (MTH1598/TM1083); Region: Archease; cl00606 1091500006163 Uncharacterized conserved protein [Function unknown]; Region: RtcB; COG1690 1091500006164 hypothetical protein; Reviewed; Region: PRK09588 1091500006165 Domain of unknown function (DUF1876); Region: DUF1876; pfam08962 1091500006166 Hemerythrin-like domain; Region: Hr-like; cd12108 1091500006167 Fe binding site [ion binding]; other site 1091500006168 PE family; Region: PE; pfam00934 1091500006169 Chloramphenicol (Cm) phosphotransferase (CPT). Cm-inactivating enzyme; modifies the primary (C-3) hydroxyl of the antibiotic. Related structurally to shikimate kinase II; Region: CPT; cl17391 1091500006170 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1091500006171 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1091500006172 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1091500006173 anti sigma factor interaction site; other site 1091500006174 regulatory phosphorylation site [posttranslational modification]; other site 1091500006175 hypothetical protein; Provisional; Region: PRK02237 1091500006176 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1091500006177 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1091500006178 putative DNA binding site [nucleotide binding]; other site 1091500006179 putative Zn2+ binding site [ion binding]; other site 1091500006180 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 1091500006181 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1091500006182 putative metal binding site [ion binding]; other site 1091500006183 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1091500006184 dimerization interface [polypeptide binding]; other site 1091500006185 putative DNA binding site [nucleotide binding]; other site 1091500006186 putative Zn2+ binding site [ion binding]; other site 1091500006187 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 1091500006188 arsenical-resistance protein; Region: acr3; TIGR00832 1091500006189 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1091500006190 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1091500006191 active site 1091500006192 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1091500006193 potential frameshift: common BLAST hit: gi|253798270|ref|YP_003031271.1| integrase 1091500006194 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 1091500006195 ParB-like nuclease domain; Region: ParBc; cl02129 1091500006196 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1091500006197 Transposase; Region: HTH_Tnp_1; cl17663 1091500006198 putative transposase OrfB; Reviewed; Region: PHA02517 1091500006199 HTH-like domain; Region: HTH_21; pfam13276 1091500006200 Integrase core domain; Region: rve; pfam00665 1091500006201 Integrase core domain; Region: rve_3; pfam13683 1091500006202 Predicted phage phi-C31 gp36 major capsid-like protein [General function prediction only]; Region: COG4653 1091500006203 Phage capsid family; Region: Phage_capsid; pfam05065 1091500006204 Phage head maturation protease [General function prediction only]; Region: COG3740 1091500006205 Phage terminase, small subunit; Region: Terminase_4; cl01525 1091500006206 Protein of unknown function (DUF3631); Region: DUF3631; pfam12307 1091500006207 Protein of unknown function (DUF2742); Region: DUF2742; pfam10888 1091500006208 DNA binding domain, excisionase family; Region: excise; TIGR01764 1091500006209 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1091500006210 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1091500006211 active site 1091500006212 catalytic residues [active] 1091500006213 DNA binding site [nucleotide binding] 1091500006214 Int/Topo IB signature motif; other site 1091500006215 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1091500006216 MULE transposase domain; Region: MULE; pfam10551 1091500006217 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1091500006218 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1091500006219 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1091500006220 Coenzyme A binding pocket [chemical binding]; other site 1091500006221 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 1091500006222 hypothetical protein; Provisional; Region: PRK14059 1091500006223 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 1091500006224 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1091500006225 TAP-like protein; Region: Abhydrolase_4; pfam08386 1091500006226 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 1091500006227 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 1091500006228 SelR domain; Region: SelR; pfam01641 1091500006229 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1091500006230 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091500006231 S-adenosylmethionine binding site [chemical binding]; other site 1091500006232 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 1091500006233 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 1091500006234 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1091500006235 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1091500006236 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1091500006237 substrate binding site [chemical binding]; other site 1091500006238 active site 1091500006239 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1091500006240 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1091500006241 substrate binding site [chemical binding]; other site 1091500006242 oxyanion hole (OAH) forming residues; other site 1091500006243 trimer interface [polypeptide binding]; other site 1091500006244 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 1091500006245 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 1091500006246 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1091500006247 catalytic site [active] 1091500006248 putative active site [active] 1091500006249 putative substrate binding site [chemical binding]; other site 1091500006250 Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154 1091500006251 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1091500006252 TPP-binding site; other site 1091500006253 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1091500006254 PYR/PP interface [polypeptide binding]; other site 1091500006255 dimer interface [polypeptide binding]; other site 1091500006256 TPP binding site [chemical binding]; other site 1091500006257 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1091500006258 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1091500006259 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1091500006260 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 1091500006261 transmembrane helices; other site 1091500006262 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1091500006263 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 1091500006264 transmembrane helices; other site 1091500006265 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1091500006266 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1091500006267 Walker A/P-loop; other site 1091500006268 ATP binding site [chemical binding]; other site 1091500006269 Q-loop/lid; other site 1091500006270 ABC transporter signature motif; other site 1091500006271 Walker B; other site 1091500006272 D-loop; other site 1091500006273 H-loop/switch region; other site 1091500006274 TRAM domain; Region: TRAM; cl01282 1091500006275 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1091500006276 potential frameshift: common BLAST hit: gi|148662531|ref|YP_001284054.1| alanine,valine and leucine rich integral membrane protein 1091500006277 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1091500006278 TrkA-N domain; Region: TrkA_N; pfam02254 1091500006279 TrkA-C domain; Region: TrkA_C; pfam02080 1091500006280 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1091500006281 TrkA-N domain; Region: TrkA_N; pfam02254 1091500006282 TrkA-C domain; Region: TrkA_C; pfam02080 1091500006283 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 1091500006284 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1091500006285 generic binding surface II; other site 1091500006286 ssDNA binding site; other site 1091500006287 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1091500006288 trimer interface [polypeptide binding]; other site 1091500006289 active site 1091500006290 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 1091500006291 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 1091500006292 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1091500006293 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1091500006294 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 1091500006295 active site 1091500006296 dimerization interface [polypeptide binding]; other site 1091500006297 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1091500006298 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1091500006299 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 1091500006300 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1091500006301 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1091500006302 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1091500006303 DNA binding residues [nucleotide binding] 1091500006304 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 1091500006305 homotrimer interaction site [polypeptide binding]; other site 1091500006306 putative active site [active] 1091500006307 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3502 1091500006308 potential frameshift: common BLAST hit: gi|224991074|ref|YP_002645763.1| transmembrane alanine and leucine rich protein 1091500006309 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 1091500006310 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 1091500006311 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1091500006312 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1091500006313 DNA binding residues [nucleotide binding] 1091500006314 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 1091500006315 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1091500006316 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1091500006317 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 1091500006318 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 1091500006319 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 1091500006320 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1091500006321 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1091500006322 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1091500006323 PAC2 family; Region: PAC2; pfam09754 1091500006324 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1091500006325 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1091500006326 Phenazine biosynthesis-like protein; Region: PhzC-PhzF; pfam02567 1091500006327 Domain of unknown function (DUF1794); Region: DUF1794; pfam08768 1091500006328 heme-binding site [chemical binding]; other site 1091500006329 ATP cone domain; Region: ATP-cone; pfam03477 1091500006330 LysM domain; Region: LysM; pfam01476 1091500006331 LexA repressor; Validated; Region: PRK00215 1091500006332 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1091500006333 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1091500006334 Catalytic site [active] 1091500006335 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 1091500006336 LGFP repeat; Region: LGFP; pfam08310 1091500006337 LGFP repeat; Region: LGFP; pfam08310 1091500006338 LGFP repeat; Region: LGFP; pfam08310 1091500006339 LGFP repeat; Region: LGFP; pfam08310 1091500006340 LGFP repeat; Region: LGFP; pfam08310 1091500006341 Integral membrane protein TerC family; Region: TerC; cl10468 1091500006342 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1091500006343 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1091500006344 active site 1091500006345 potential frameshift: common BLAST hit: gi|339632737|ref|YP_004724379.1| GTP-binding protein HFLX 1091500006346 diaminopimelate epimerase; Region: DapF; TIGR00652 1091500006347 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1091500006348 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1091500006349 potential frameshift: common BLAST hit: gi|340627728|ref|YP_004746180.1| putative tRNA delta 1091500006350 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 1091500006351 active site 1091500006352 metal binding site [ion binding]; metal-binding site 1091500006353 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 1091500006354 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1091500006355 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1091500006356 FeS/SAM binding site; other site 1091500006357 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1091500006358 FeS/SAM binding site; other site 1091500006359 potential frameshift: common BLAST hit: gi|15842275|ref|NP_337312.1| recombination regulator RecX 1091500006360 DNA recombination protein RecA; Reviewed; Region: recA; PRK09519 1091500006361 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1091500006362 hexamer interface [polypeptide binding]; other site 1091500006363 Walker A motif; other site 1091500006364 ATP binding site [chemical binding]; other site 1091500006365 Walker B motif; other site 1091500006366 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1091500006367 protein-splicing catalytic site; other site 1091500006368 thioester formation/cholesterol transfer; other site 1091500006369 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 1091500006370 recA bacterial DNA recombination protein; Region: RecA; cl17211 1091500006371 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 1091500006372 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 1091500006373 potential frameshift: common BLAST hit: gi|339632752|ref|YP_004724394.1| transferase 1091500006374 Limonene-1,2-epoxide hydrolase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LimA; COG4308 1091500006375 PE family; Region: PE; pfam00934 1091500006376 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 1091500006377 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1091500006378 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1091500006379 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1091500006380 non-specific DNA binding site [nucleotide binding]; other site 1091500006381 salt bridge; other site 1091500006382 sequence-specific DNA binding site [nucleotide binding]; other site 1091500006383 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1091500006384 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1091500006385 Coenzyme A binding pocket [chemical binding]; other site 1091500006386 potential frameshift: common BLAST hit: gi|15842288|ref|NP_337325.1| cell division protein FtsK 1091500006387 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1091500006388 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 1091500006389 classical (c) SDRs; Region: SDR_c; cd05233 1091500006390 NAD(P) binding site [chemical binding]; other site 1091500006391 active site 1091500006392 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1091500006393 Leucine carboxyl methyltransferase; Region: LCM; cl01306 1091500006394 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1091500006395 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1091500006396 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1091500006397 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1091500006398 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1091500006399 dimer interface [polypeptide binding]; other site 1091500006400 active site 1091500006401 catalytic residue [active] 1091500006402 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 1091500006403 potential frameshift: common BLAST hit: gi|253798162|ref|YP_003031163.1| type I restriction/modification system DNA methylase hsdM 1091500006404 potential frameshift: common BLAST hit: gi|253798162|ref|YP_003031163.1| type I restriction/modification system DNA methylase hsdM 1091500006405 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 1091500006406 putative active site [active] 1091500006407 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 1091500006408 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 1091500006409 putative active site [active] 1091500006410 Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704 1091500006411 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1091500006412 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1091500006413 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 1091500006414 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426 1091500006415 potential frameshift: common BLAST hit: gi|253798154|ref|YP_003031155.1| thymidylate synthase 1091500006416 Dienelactone hydrolase family; Region: DLH; pfam01738 1091500006417 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 1091500006418 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1091500006419 classical (c) SDRs; Region: SDR_c; cd05233 1091500006420 NAD(P) binding site [chemical binding]; other site 1091500006421 active site 1091500006422 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1091500006423 PPE family; Region: PPE; pfam00823 1091500006424 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1091500006425 PE family; Region: PE; pfam00934 1091500006426 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1091500006427 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1091500006428 PPE family; Region: PPE; pfam00823 1091500006429 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1091500006430 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1091500006431 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1091500006432 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1091500006433 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1091500006434 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1091500006435 Coenzyme A binding pocket [chemical binding]; other site 1091500006436 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1091500006437 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 1091500006438 FMN-binding pocket [chemical binding]; other site 1091500006439 flavin binding motif; other site 1091500006440 phosphate binding motif [ion binding]; other site 1091500006441 beta-alpha-beta structure motif; other site 1091500006442 NAD binding pocket [chemical binding]; other site 1091500006443 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1091500006444 catalytic loop [active] 1091500006445 iron binding site [ion binding]; other site 1091500006446 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 1091500006447 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1091500006448 hydrophobic ligand binding site; other site 1091500006449 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1091500006450 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1091500006451 putative DNA binding site [nucleotide binding]; other site 1091500006452 putative Zn2+ binding site [ion binding]; other site 1091500006453 AsnC family; Region: AsnC_trans_reg; pfam01037 1091500006454 alanine dehydrogenase; Region: alaDH; TIGR00518 1091500006455 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1091500006456 hexamer interface [polypeptide binding]; other site 1091500006457 ligand binding site [chemical binding]; other site 1091500006458 putative active site [active] 1091500006459 NAD(P) binding site [chemical binding]; other site 1091500006460 Nitronate monooxygenase; Region: NMO; pfam03060 1091500006461 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1091500006462 FMN binding site [chemical binding]; other site 1091500006463 substrate binding site [chemical binding]; other site 1091500006464 putative catalytic residue [active] 1091500006465 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1091500006466 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1091500006467 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1091500006468 potential frameshift: common BLAST hit: gi|339632794|ref|YP_004724436.1| polyribonucleotide nucleotidyltransferase 1091500006469 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1091500006470 16S/18S rRNA binding site [nucleotide binding]; other site 1091500006471 S13e-L30e interaction site [polypeptide binding]; other site 1091500006472 25S rRNA binding site [nucleotide binding]; other site 1091500006473 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1091500006474 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1091500006475 active site 1091500006476 Riboflavin kinase; Region: Flavokinase; pfam01687 1091500006477 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 1091500006478 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1091500006479 putative DNA binding site [nucleotide binding]; other site 1091500006480 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1091500006481 FeoA domain; Region: FeoA; pfam04023 1091500006482 potential frameshift: common BLAST hit: gi|340627791|ref|YP_004746243.1| putative acyl-CoA dehydrogenase FADE21 1091500006483 lipid-transfer protein; Provisional; Region: PRK08256 1091500006484 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1091500006485 active site 1091500006486 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1091500006487 Probable transposase; Region: OrfB_IS605; pfam01385 1091500006488 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 1091500006489 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 1091500006490 catalytic residues [active] 1091500006491 catalytic nucleophile [active] 1091500006492 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 1091500006493 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1091500006494 RNA binding site [nucleotide binding]; other site 1091500006495 active site 1091500006496 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 1091500006497 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 1091500006498 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1091500006499 Uncharacterized conserved protein [Function unknown]; Region: COG4717 1091500006500 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 1091500006501 potential frameshift: common BLAST hit: gi|339632811|ref|YP_004724453.1| hydrolase 1091500006502 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 1091500006503 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 1091500006504 Uncharacterized conserved protein [Function unknown]; Region: COG5586 1091500006505 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 1091500006506 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1091500006507 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1091500006508 Helix-turn-helix domain; Region: HTH_28; pfam13518 1091500006509 Winged helix-turn helix; Region: HTH_29; pfam13551 1091500006510 Integrase core domain; Region: rve; pfam00665 1091500006511 Integrase core domain; Region: rve_3; pfam13683 1091500006512 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 1091500006513 AAA domain; Region: AAA_22; pfam13401 1091500006514 putative transposase OrfB; Reviewed; Region: PHA02517 1091500006515 HTH-like domain; Region: HTH_21; pfam13276 1091500006516 Integrase core domain; Region: rve; pfam00665 1091500006517 Integrase core domain; Region: rve_3; pfam13683 1091500006518 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1091500006519 Transposase; Region: HTH_Tnp_1; cl17663 1091500006520 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638 1091500006521 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09636 1091500006522 CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cd09699 1091500006523 CRISPR/Cas system-associated RAMP superfamily protein Csm5; Region: Csm5_III-A; cd09662 1091500006524 CRISPR/Cas system-associated RAMP superfamily protein Csm4; Region: Csm4_III-A; cd09663 1091500006525 CRISPR/Cas system-associated RAMP superfamily protein Csm3; Region: Csm3_III-A; cd09684 1091500006526 CRISPR/Cas system-associated protein Csm2; Region: Csm2_III-A; cd09647 1091500006527 Predicted CRISPR-associated polymerase [Defense mechanisms]; Region: COG1353 1091500006528 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680 1091500006529 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 1091500006530 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4293 1091500006531 Uncharacterized conserved protein [Function unknown]; Region: COG2253 1091500006532 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4293 1091500006533 Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041 1091500006534 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 1091500006535 putative active site [active] 1091500006536 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1091500006537 enoyl-CoA hydratase; Provisional; Region: PRK06190 1091500006538 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1091500006539 substrate binding site [chemical binding]; other site 1091500006540 oxyanion hole (OAH) forming residues; other site 1091500006541 trimer interface [polypeptide binding]; other site 1091500006542 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1091500006543 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1091500006544 Walker A/P-loop; other site 1091500006545 ATP binding site [chemical binding]; other site 1091500006546 Q-loop/lid; other site 1091500006547 ABC transporter signature motif; other site 1091500006548 Walker B; other site 1091500006549 D-loop; other site 1091500006550 H-loop/switch region; other site 1091500006551 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1091500006552 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1091500006553 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1091500006554 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1091500006555 dimer interface [polypeptide binding]; other site 1091500006556 conserved gate region; other site 1091500006557 putative PBP binding loops; other site 1091500006558 ABC-ATPase subunit interface; other site 1091500006559 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1091500006560 ABC-ATPase subunit interface; other site 1091500006561 potential frameshift: common BLAST hit: gi|339632845|ref|YP_004724487.1| DNA-damage-inducible protein F DINF 1091500006562 Ribosome-binding factor A; Region: RBFA; cl00542 1091500006563 potential frameshift: common BLAST hit: gi|339632848|ref|YP_004724490.1| translation initiation factor 2 1091500006564 potential frameshift: common BLAST hit: gi|340627832|ref|YP_004746284.1| putative translation initiation factor IF-2 INFB 1091500006565 Predicted nucleic-acid-binding protein implicated in transcription termination [Transcription]; Region: COG2740 1091500006566 putative RNA binding cleft [nucleotide binding]; other site 1091500006567 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1091500006568 NusA N-terminal domain; Region: NusA_N; pfam08529 1091500006569 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1091500006570 RNA binding site [nucleotide binding]; other site 1091500006571 homodimer interface [polypeptide binding]; other site 1091500006572 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1091500006573 G-X-X-G motif; other site 1091500006574 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1091500006575 G-X-X-G motif; other site 1091500006576 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1091500006577 Sm and related proteins; Region: Sm_like; cl00259 1091500006578 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1091500006579 putative oligomer interface [polypeptide binding]; other site 1091500006580 putative RNA binding site [nucleotide binding]; other site 1091500006581 Mitochondrial ATP synthase g subunit; Region: ATP-synt_G; pfam04718 1091500006582 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1091500006583 dinuclear metal binding motif [ion binding]; other site 1091500006584 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 1091500006585 putative deacylase active site [active] 1091500006586 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1091500006587 active site 1091500006588 motif 3; other site 1091500006589 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1091500006590 anticodon binding site; other site 1091500006591 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1091500006592 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1091500006593 dimer interface [polypeptide binding]; other site 1091500006594 motif 1; other site 1091500006595 active site 1091500006596 motif 2; other site 1091500006597 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 1091500006598 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1091500006599 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1091500006600 putative substrate translocation pore; other site 1091500006601 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 1091500006602 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1091500006603 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1091500006604 homodimer interface [polypeptide binding]; other site 1091500006605 active site 1091500006606 SAM binding site [chemical binding]; other site 1091500006607 potential frameshift: common BLAST hit: gi|339632857|ref|YP_004724499.1| cobyrinic acid A,C-diamide synthase COBB 1091500006608 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 1091500006609 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 1091500006610 homodimer interface [polypeptide binding]; other site 1091500006611 Walker A motif; other site 1091500006612 ATP binding site [chemical binding]; other site 1091500006613 hydroxycobalamin binding site [chemical binding]; other site 1091500006614 Walker B motif; other site 1091500006615 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 1091500006616 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1091500006617 Walker A motif; other site 1091500006618 ATP binding site [chemical binding]; other site 1091500006619 Walker B motif; other site 1091500006620 arginine finger; other site 1091500006621 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 1091500006622 metal ion-dependent adhesion site (MIDAS); other site 1091500006623 Predicted acyltransferase [General function prediction only]; Region: ElaA; COG2153 1091500006624 malate:quinone oxidoreductase; Validated; Region: PRK05257 1091500006625 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1091500006626 potential frameshift: common BLAST hit: gi|57117029|ref|YP_177909.1| PE-PGRS family protein 1091500006627 potential frameshift: common BLAST hit: gi|253798061|ref|YP_003031062.1| PE-PGRS family protein 1091500006628 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1091500006629 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1091500006630 mycothione reductase; Reviewed; Region: PRK07846 1091500006631 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1091500006632 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1091500006633 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1091500006634 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 1091500006635 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1091500006636 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1091500006637 short chain dehydrogenase; Provisional; Region: PRK06057 1091500006638 classical (c) SDRs; Region: SDR_c; cd05233 1091500006639 NAD(P) binding site [chemical binding]; other site 1091500006640 active site 1091500006641 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1091500006642 NAD(P)+ dependent aldehyde dehydrogenase family; Region: ALDH; cd07078 1091500006643 NAD(P) binding site [chemical binding]; other site 1091500006644 catalytic residues [active] 1091500006645 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 1091500006646 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1091500006647 catalytic triad [active] 1091500006648 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1091500006649 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1091500006650 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1091500006651 potential frameshift: common BLAST hit: gi|340627854|ref|YP_004746306.1| putative methionine aminopeptidase MAPB 1091500006652 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1091500006653 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 1091500006654 putative active site [active] 1091500006655 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 1091500006656 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1091500006657 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1091500006658 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 1091500006659 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 1091500006660 Predicted acetyltransferase [General function prediction only]; Region: COG3393 1091500006661 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 1091500006662 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1091500006663 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1091500006664 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1091500006665 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 1091500006666 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1091500006667 active site 1091500006668 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1091500006669 protein binding site [polypeptide binding]; other site 1091500006670 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1091500006671 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1091500006672 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1091500006673 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1091500006674 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1091500006675 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 1091500006676 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 1091500006677 Fasciclin domain; Region: Fasciclin; pfam02469 1091500006678 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1091500006679 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1091500006680 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1091500006681 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 1091500006682 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1091500006683 catalytic residues [active] 1091500006684 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 1091500006685 Fasciclin domain; Region: Fasciclin; pfam02469 1091500006686 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 1091500006687 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1091500006688 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 1091500006689 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1091500006690 catalytic residues [active] 1091500006691 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 1091500006692 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1091500006693 FeS/SAM binding site; other site 1091500006694 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1091500006695 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1091500006696 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1091500006697 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1091500006698 hinge region; other site 1091500006699 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1091500006700 putative nucleotide binding site [chemical binding]; other site 1091500006701 uridine monophosphate binding site [chemical binding]; other site 1091500006702 homohexameric interface [polypeptide binding]; other site 1091500006703 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1091500006704 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1091500006705 DNA binding site [nucleotide binding] 1091500006706 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1091500006707 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1091500006708 Probable transposase; Region: OrfB_IS605; pfam01385 1091500006709 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 1091500006710 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 1091500006711 catalytic residues [active] 1091500006712 catalytic nucleophile [active] 1091500006713 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1091500006714 MarR family; Region: MarR; pfam01047 1091500006715 potential frameshift: common BLAST hit: gi|339632895|ref|YP_004724537.1| aminohydrolase 1091500006716 potential frameshift: common BLAST hit: gi|339632895|ref|YP_004724537.1| aminohydrolase 1091500006717 elongation factor Ts; Provisional; Region: tsf; PRK09377 1091500006718 UBA/TS-N domain; Region: UBA; pfam00627 1091500006719 Elongation factor TS; Region: EF_TS; pfam00889 1091500006720 Elongation factor TS; Region: EF_TS; pfam00889 1091500006721 potential frameshift: common BLAST hit: gi|340627880|ref|YP_004746332.1| putative 30S ribosomal protein S2 RPSB 1091500006722 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1091500006723 PPE family; Region: PPE; pfam00823 1091500006724 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 1091500006725 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1091500006726 potential frameshift: common BLAST hit: gi|340627884|ref|YP_004746336.1| putative integrase/recombinase XERC 1091500006727 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1091500006728 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1091500006729 FAD binding pocket [chemical binding]; other site 1091500006730 FAD binding motif [chemical binding]; other site 1091500006731 phosphate binding motif [ion binding]; other site 1091500006732 NAD binding pocket [chemical binding]; other site 1091500006733 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 1091500006734 DNA protecting protein DprA; Region: dprA; TIGR00732 1091500006735 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1091500006736 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1091500006737 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1091500006738 Walker A motif; other site 1091500006739 ATP binding site [chemical binding]; other site 1091500006740 Walker B motif; other site 1091500006741 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1091500006742 hypothetical protein; Reviewed; Region: PRK12497 1091500006743 potential frameshift: common BLAST hit: gi|340627889|ref|YP_004746341.1| putative FDHD protein-like protein 1091500006744 potential frameshift: common BLAST hit: gi|339632906|ref|YP_004724548.1| formate dehydrogenase 1091500006745 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 1091500006746 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1091500006747 RNA/DNA hybrid binding site [nucleotide binding]; other site 1091500006748 active site 1091500006749 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1091500006750 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1091500006751 Catalytic site [active] 1091500006752 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1091500006753 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1091500006754 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1091500006755 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1091500006756 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1091500006757 RimM N-terminal domain; Region: RimM; pfam01782 1091500006758 hypothetical protein; Provisional; Region: PRK02821 1091500006759 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 1091500006760 G-X-X-G motif; other site 1091500006761 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 1091500006762 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1091500006763 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1091500006764 potential frameshift: common BLAST hit: gi|340627902|ref|YP_004746354.1| putative transcriptional regulatory protein 1091500006765 potential frameshift: common BLAST hit: gi|339632919|ref|YP_004724561.1| D-amino acid aminohydrolase 1091500006766 potential frameshift: common BLAST hit: gi|339632919|ref|YP_004724561.1| D-amino acid aminohydrolase 1091500006767 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1091500006768 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1091500006769 active site 1091500006770 ATP binding site [chemical binding]; other site 1091500006771 substrate binding site [chemical binding]; other site 1091500006772 activation loop (A-loop); other site 1091500006773 potential frameshift: common BLAST hit: gi|340627906|ref|YP_004746358.1| putative signal recognition particle protein FFH 1091500006774 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1091500006775 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1091500006776 ATP binding site [chemical binding]; other site 1091500006777 putative Mg++ binding site [ion binding]; other site 1091500006778 PII uridylyl-transferase; Provisional; Region: PRK03381 1091500006779 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1091500006780 metal binding triad; other site 1091500006781 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1091500006782 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1091500006783 Zn2+ binding site [ion binding]; other site 1091500006784 Mg2+ binding site [ion binding]; other site 1091500006785 potential frameshift: common BLAST hit: gi|340627909|ref|YP_004746361.1| putative nitrogen regulatorY protein P-II GLNB 1091500006786 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1091500006787 potential frameshift: common BLAST hit: gi|339632927|ref|YP_004724569.1| cell division protein FtsY 1091500006788 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1091500006789 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1091500006790 Walker A/P-loop; other site 1091500006791 ATP binding site [chemical binding]; other site 1091500006792 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 1091500006793 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1091500006794 ABC transporter signature motif; other site 1091500006795 Walker B; other site 1091500006796 D-loop; other site 1091500006797 H-loop/switch region; other site 1091500006798 acylphosphatase; Provisional; Region: PRK14422 1091500006799 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 1091500006800 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1091500006801 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1091500006802 DNA binding site [nucleotide binding] 1091500006803 catalytic residue [active] 1091500006804 H2TH interface [polypeptide binding]; other site 1091500006805 putative catalytic residues [active] 1091500006806 turnover-facilitating residue; other site 1091500006807 intercalation triad [nucleotide binding]; other site 1091500006808 8OG recognition residue [nucleotide binding]; other site 1091500006809 putative reading head residues; other site 1091500006810 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1091500006811 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1091500006812 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1091500006813 metal binding site [ion binding]; metal-binding site 1091500006814 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1091500006815 dsRNA binding site [nucleotide binding]; other site 1091500006816 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 1091500006817 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 1091500006818 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 1091500006819 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1091500006820 acyl-CoA synthetase; Validated; Region: PRK05850 1091500006821 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1091500006822 acyl-activating enzyme (AAE) consensus motif; other site 1091500006823 active site 1091500006824 potential frameshift: common BLAST hit: gi|224991305|ref|YP_002645994.1| phenolpthiocerol synthesis type-I polyketide synthase 1091500006825 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1091500006826 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1091500006827 active site 1091500006828 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1091500006829 Acyl transferase domain; Region: Acyl_transf_1; cl08282 1091500006830 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 1091500006831 KR domain; Region: KR; pfam08659 1091500006832 NADP binding site [chemical binding]; other site 1091500006833 active site 1091500006834 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1091500006835 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1091500006836 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1091500006837 active site 1091500006838 potential frameshift: common BLAST hit: gi|339632940|ref|YP_004724582.1| phenolpthiocerol synthesis type-I polyketide synthase PPSC 1091500006839 potential frameshift: common BLAST hit: gi|339632940|ref|YP_004724582.1| phenolpthiocerol synthesis type-I polyketide synthase PPSC 1091500006840 potential frameshift: common BLAST hit: gi|339632941|ref|YP_004724583.1| phenolpthiocerol synthesis type-I polyketide synthase PPSD 1091500006841 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1091500006842 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1091500006843 active site 1091500006844 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1091500006845 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1091500006846 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1091500006847 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1091500006848 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1091500006849 Walker A/P-loop; other site 1091500006850 ATP binding site [chemical binding]; other site 1091500006851 Q-loop/lid; other site 1091500006852 ABC transporter signature motif; other site 1091500006853 Walker B; other site 1091500006854 D-loop; other site 1091500006855 H-loop/switch region; other site 1091500006856 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1091500006857 ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025 1091500006858 ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025 1091500006859 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1091500006860 acyltransferase PapA5; Provisional; Region: PRK09294 1091500006861 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1091500006862 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1091500006863 active site 1091500006864 Acyl transferase domain; Region: Acyl_transf_1; pfam00698 1091500006865 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1091500006866 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1091500006867 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1091500006868 Enoylreductase; Region: PKS_ER; smart00829 1091500006869 NAD(P) binding site [chemical binding]; other site 1091500006870 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1091500006871 KR domain; Region: KR; pfam08659 1091500006872 putative NADP binding site [chemical binding]; other site 1091500006873 active site 1091500006874 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1091500006875 acyl-CoA synthetase; Validated; Region: PRK05850 1091500006876 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1091500006877 acyl-activating enzyme (AAE) consensus motif; other site 1091500006878 active site 1091500006879 potential frameshift: common BLAST hit: gi|253797970|ref|YP_003030971.1| transmembrane transporter mmpL7 1091500006880 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1091500006881 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1091500006882 Integrase core domain; Region: rve; pfam00665 1091500006883 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1091500006884 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1091500006885 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 1091500006886 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 1091500006887 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1091500006888 putative NADP binding site [chemical binding]; other site 1091500006889 active site 1091500006890 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1091500006891 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1091500006892 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1091500006893 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1091500006894 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1091500006895 Enoylreductase; Region: PKS_ER; smart00829 1091500006896 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1091500006897 NAD(P) binding site [chemical binding]; other site 1091500006898 Erythronolide synthase docking; Region: Docking; pfam08990 1091500006899 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1091500006900 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1091500006901 active site 1091500006902 acyl-CoA synthetase; Validated; Region: PRK06060 1091500006903 Benzoate CoA ligase (BCL) and similar adenylate forming enzymes; Region: BCL_like; cd05919 1091500006904 dimer interface [polypeptide binding]; other site 1091500006905 acyl-activating enzyme (AAE) consensus motif; other site 1091500006906 putative active site [active] 1091500006907 putative AMP binding site [chemical binding]; other site 1091500006908 putative CoA binding site [chemical binding]; other site 1091500006909 chemical substrate binding site [chemical binding]; other site 1091500006910 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1091500006911 4-hydroxybenzoate synthetase (chorismate lyase) [Coenzyme metabolism]; Region: UbiC; COG3161 1091500006912 acyl-CoA synthetase; Validated; Region: PRK05850 1091500006913 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1091500006914 acyl-activating enzyme (AAE) consensus motif; other site 1091500006915 active site 1091500006916 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1091500006917 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1091500006918 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091500006919 S-adenosylmethionine binding site [chemical binding]; other site 1091500006920 Uncharacterized conserved protein [Function unknown]; Region: COG3268 1091500006921 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1091500006922 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091500006923 S-adenosylmethionine binding site [chemical binding]; other site 1091500006924 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 1091500006925 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 1091500006926 potential frameshift: common BLAST hit: gi|340627946|ref|YP_004746398.1| putative GLYCOSYL transferase 1091500006927 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1091500006928 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1091500006929 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1091500006930 active site 1091500006931 TDP-binding site; other site 1091500006932 acceptor substrate-binding pocket; other site 1091500006933 potential frameshift: common BLAST hit: gi|340627950|ref|YP_004746402.1| putative methyltransferase 1091500006934 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 1091500006935 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1091500006936 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1091500006937 active site 1091500006938 TDP-binding site; other site 1091500006939 acceptor substrate-binding pocket; other site 1091500006940 Predicted permease; Region: DUF318; pfam03773 1091500006941 formyltetrahydrofolate deformylase; Region: PurU; TIGR00655 1091500006942 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1091500006943 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1091500006944 putative active site [active] 1091500006945 putative substrate binding site [chemical binding]; other site 1091500006946 putative cosubstrate binding site; other site 1091500006947 catalytic site [active] 1091500006948 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1091500006949 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1091500006950 active site 1091500006951 (T/H)XGH motif; other site 1091500006952 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 1091500006953 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091500006954 S-adenosylmethionine binding site [chemical binding]; other site 1091500006955 pyruvate carboxylase; Reviewed; Region: PRK12999 1091500006956 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1091500006957 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1091500006958 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1091500006959 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1091500006960 active site 1091500006961 catalytic residues [active] 1091500006962 metal binding site [ion binding]; metal-binding site 1091500006963 homodimer binding site [polypeptide binding]; other site 1091500006964 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1091500006965 carboxyltransferase (CT) interaction site; other site 1091500006966 biotinylation site [posttranslational modification]; other site 1091500006967 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 1091500006968 putative active site [active] 1091500006969 redox center [active] 1091500006970 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1091500006971 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 1091500006972 catalytic residues [active] 1091500006973 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1091500006974 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1091500006975 substrate binding pocket [chemical binding]; other site 1091500006976 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 1091500006977 potential frameshift: common BLAST hit: gi|253797937|ref|YP_003030938.1| oxidoreductase 1091500006978 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1091500006979 RecG-like helicase [DNA replication, recombination, and repair / Transcription]; Region: RecG; COG1200 1091500006980 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1091500006981 generic binding surface II; other site 1091500006982 ssDNA binding site; other site 1091500006983 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1091500006984 ATP binding site [chemical binding]; other site 1091500006985 putative Mg++ binding site [ion binding]; other site 1091500006986 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1091500006987 nucleotide binding region [chemical binding]; other site 1091500006988 ATP-binding site [chemical binding]; other site 1091500006989 potential frameshift: common BLAST hit: gi|340627964|ref|YP_004746416.1| dak2 domain-containing protein 1091500006990 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1091500006991 potential frameshift: common BLAST hit: gi|340627965|ref|YP_004746417.1| putative uracil-DNA glycosylase UNG (UDG) 1091500006992 thiamine monophosphate kinase; Provisional; Region: PRK05731 1091500006993 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1091500006994 ATP binding site [chemical binding]; other site 1091500006995 dimerization interface [polypeptide binding]; other site 1091500006996 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1091500006997 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1091500006998 Probable transposase; Region: OrfB_IS605; pfam01385 1091500006999 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 1091500007000 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 1091500007001 catalytic residues [active] 1091500007002 catalytic nucleophile [active] 1091500007003 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 1091500007004 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1091500007005 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1091500007006 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1091500007007 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1091500007008 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1091500007009 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1091500007010 Predicted nucleotidyltransferase, CobY/MobA/RfbA family [General function prediction only]; Region: COG1920 1091500007011 polyphosphate kinase; Provisional; Region: PRK05443 1091500007012 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1091500007013 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1091500007014 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 1091500007015 putative domain interface [polypeptide binding]; other site 1091500007016 putative active site [active] 1091500007017 catalytic site [active] 1091500007018 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 1091500007019 putative domain interface [polypeptide binding]; other site 1091500007020 putative active site [active] 1091500007021 catalytic site [active] 1091500007022 potential frameshift: common BLAST hit: gi|340627974|ref|YP_004746426.1| putative hydrolase MUTT1 1091500007023 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1091500007024 IHF - DNA interface [nucleotide binding]; other site 1091500007025 IHF dimer interface [polypeptide binding]; other site 1091500007026 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1091500007027 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1091500007028 substrate binding site [chemical binding]; other site 1091500007029 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1091500007030 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1091500007031 substrate binding site [chemical binding]; other site 1091500007032 ligand binding site [chemical binding]; other site 1091500007033 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1091500007034 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1091500007035 Bacterial transcriptional regulator; Region: IclR; pfam01614 1091500007036 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091500007037 S-adenosylmethionine binding site [chemical binding]; other site 1091500007038 potential protein location (hypothetical protein MRGA327_18390 [Mycobacterium tuberculosis RGTB327]) that overlaps RNA (tRNA-E) 1091500007039 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1091500007040 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1091500007041 active site 1091500007042 HIGH motif; other site 1091500007043 nucleotide binding site [chemical binding]; other site 1091500007044 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1091500007045 active site 1091500007046 KMSKS motif; other site 1091500007047 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 1091500007048 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1091500007049 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1091500007050 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1091500007051 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1091500007052 putative substrate translocation pore; other site 1091500007053 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 1091500007054 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 1091500007055 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1091500007056 ligand binding site [chemical binding]; other site 1091500007057 NAD binding site [chemical binding]; other site 1091500007058 dimerization interface [polypeptide binding]; other site 1091500007059 catalytic site [active] 1091500007060 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 1091500007061 putative L-serine binding site [chemical binding]; other site 1091500007062 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1091500007063 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1091500007064 Protein of unknown function (DUF433); Region: DUF433; pfam04255 1091500007065 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1091500007066 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1091500007067 phosphorylation site [posttranslational modification] 1091500007068 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 1091500007069 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 1091500007070 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 1091500007071 potential frameshift: common BLAST hit: gi|345462017|ref|NP_217517.2| ketol-acid reductoisomerase 1091500007072 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1091500007073 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1091500007074 putative valine binding site [chemical binding]; other site 1091500007075 dimer interface [polypeptide binding]; other site 1091500007076 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1091500007077 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 1091500007078 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1091500007079 PYR/PP interface [polypeptide binding]; other site 1091500007080 dimer interface [polypeptide binding]; other site 1091500007081 TPP binding site [chemical binding]; other site 1091500007082 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1091500007083 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1091500007084 TPP-binding site [chemical binding]; other site 1091500007085 dimer interface [polypeptide binding]; other site 1091500007086 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1091500007087 Predicted membrane protein [Function unknown]; Region: COG2259 1091500007088 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 1091500007089 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1091500007090 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1091500007091 potential frameshift: common BLAST hit: gi|339633016|ref|YP_004724658.1| glutamyl-tRNA(GLN) amidotransferase subunit B 1091500007092 6-phosphofructokinase; Provisional; Region: PRK03202 1091500007093 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1091500007094 active site 1091500007095 ADP/pyrophosphate binding site [chemical binding]; other site 1091500007096 dimerization interface [polypeptide binding]; other site 1091500007097 allosteric effector site; other site 1091500007098 fructose-1,6-bisphosphate binding site; other site 1091500007099 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1091500007100 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1091500007101 aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, C subunit; Region: gatC; TIGR00135 1091500007102 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 1091500007103 Ligase N family; Region: LIGANc; smart00532 1091500007104 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 1091500007105 nucleotide binding pocket [chemical binding]; other site 1091500007106 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1091500007107 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1091500007108 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 1091500007109 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1091500007110 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1091500007111 Dimer interface [polypeptide binding]; other site 1091500007112 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310 1091500007113 PknH-like extracellular domain; Region: PknH_C; pfam14032 1091500007114 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1091500007115 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1091500007116 PPE family; Region: PPE; pfam00823 1091500007117 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1091500007118 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1091500007119 PPE family; Region: PPE; pfam00823 1091500007120 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1091500007121 MULE transposase domain; Region: MULE; pfam10551 1091500007122 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 1091500007123 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1091500007124 Ligand Binding Site [chemical binding]; other site 1091500007125 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1091500007126 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 1091500007127 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1091500007128 catalytic residue [active] 1091500007129 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1091500007130 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1091500007131 putative acyl-acceptor binding pocket; other site 1091500007132 Putative hemolysin [General function prediction only]; Region: COG3176 1091500007133 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1091500007134 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1091500007135 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1091500007136 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1091500007137 Ligand binding site [chemical binding]; other site 1091500007138 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1091500007139 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091500007140 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1091500007141 S-adenosylmethionine binding site [chemical binding]; other site 1091500007142 Uncharacterized conserved protein [Function unknown]; Region: COG1543 1091500007143 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 1091500007144 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 1091500007145 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1091500007146 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1091500007147 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 1091500007148 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 1091500007149 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1091500007150 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1091500007151 trimer interface [polypeptide binding]; other site 1091500007152 active site 1091500007153 substrate binding site [chemical binding]; other site 1091500007154 CoA binding site [chemical binding]; other site 1091500007155 FOG: WD40-like repeat [Function unknown]; Region: COG1520 1091500007156 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1091500007157 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091500007158 S-adenosylmethionine binding site [chemical binding]; other site 1091500007159 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1091500007160 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1091500007161 substrate binding site [chemical binding]; other site 1091500007162 oxyanion hole (OAH) forming residues; other site 1091500007163 trimer interface [polypeptide binding]; other site 1091500007164 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119 1091500007165 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1091500007166 Walker A/P-loop; other site 1091500007167 ATP binding site [chemical binding]; other site 1091500007168 Q-loop/lid; other site 1091500007169 ABC transporter signature motif; other site 1091500007170 Walker B; other site 1091500007171 D-loop; other site 1091500007172 H-loop/switch region; other site 1091500007173 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 1091500007174 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 1091500007175 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1091500007176 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1091500007177 motif II; other site 1091500007178 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1091500007179 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1091500007180 D-pathway; other site 1091500007181 Putative ubiquinol binding site [chemical binding]; other site 1091500007182 Low-spin heme (heme b) binding site [chemical binding]; other site 1091500007183 Putative water exit pathway; other site 1091500007184 Binuclear center (heme o3/CuB) [ion binding]; other site 1091500007185 K-pathway; other site 1091500007186 Putative proton exit pathway; other site 1091500007187 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 1091500007188 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1091500007189 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1091500007190 siderophore binding site; other site 1091500007191 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1091500007192 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1091500007193 putative NAD(P) binding site [chemical binding]; other site 1091500007194 putative substrate binding site [chemical binding]; other site 1091500007195 catalytic Zn binding site [ion binding]; other site 1091500007196 structural Zn binding site [ion binding]; other site 1091500007197 dimer interface [polypeptide binding]; other site 1091500007198 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 1091500007199 potential frameshift: common BLAST hit: gi|340628040|ref|YP_004746492.1| ribonucleoside-diphosphate reductase subunit beta NRDF2 1091500007200 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1091500007201 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1091500007202 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1091500007203 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1091500007204 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1091500007205 dimer interface [polypeptide binding]; other site 1091500007206 effector binding site; other site 1091500007207 active site 1091500007208 R2 peptide binding site; other site 1091500007209 catalytic residues [active] 1091500007210 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1091500007211 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 1091500007212 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1091500007213 catalytic residues [active] 1091500007214 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1091500007215 Predicted flavoprotein [General function prediction only]; Region: COG0431 1091500007216 DNA polymerase IV; Validated; Region: PRK03352 1091500007217 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1091500007218 active site 1091500007219 DNA binding site [nucleotide binding] 1091500007220 potential frameshift: common BLAST hit: gi|253797844|ref|YP_003030845.1| short chain dehydrogenase 1091500007221 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1091500007222 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1091500007223 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1091500007224 Cytochrome P450; Region: p450; cl12078 1091500007225 potential frameshift: common BLAST hit: gi|15842628|ref|NP_337665.1| GntR family transcriptional regulator 1091500007226 potential frameshift: common BLAST hit: gi|253797840|ref|YP_003030841.1| acyl-CoA dehydrogenase 1091500007227 potential frameshift: common BLAST hit: gi|339633069|ref|YP_004724711.1| acyl-CoA dehydrogenase 1091500007228 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180 1091500007229 Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901 1091500007230 active site 1091500007231 DNA binding site [nucleotide binding] 1091500007232 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 1091500007233 DNA binding site [nucleotide binding] 1091500007234 potential frameshift: common BLAST hit: gi|253797837|ref|YP_003030838.1| carbon starvation protein A cstA 1091500007235 Predicted membrane protein [Function unknown]; Region: COG2259 1091500007236 Small Multidrug Resistance protein; Region: Multi_Drug_Res; pfam00893 1091500007237 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 1091500007238 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1091500007239 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1091500007240 phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132 1091500007241 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 1091500007242 active site 1091500007243 substrate binding site [chemical binding]; other site 1091500007244 metal binding site [ion binding]; metal-binding site 1091500007245 camphor resistance protein CrcB; Provisional; Region: PRK14216 1091500007246 camphor resistance protein CrcB; Provisional; Region: PRK14228 1091500007247 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 1091500007248 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 1091500007249 Uncharacterized ACR, COG1993; Region: DUF190; pfam02641 1091500007250 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1091500007251 Uncharacterized conserved protein [Function unknown]; Region: COG3189 1091500007252 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1091500007253 active site 1091500007254 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1091500007255 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1091500007256 Sulfatase; Region: Sulfatase; pfam00884 1091500007257 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1091500007258 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1091500007259 potential frameshift: common BLAST hit: gi|339633088|ref|YP_004724730.1| Ser/Thr protein kinase 1091500007260 potential frameshift: common BLAST hit: gi|339633088|ref|YP_004724730.1| Ser/Thr protein kinase 1091500007261 Nucleotidyl transferase of unknown function (DUF2204); Region: DUF2204; pfam09970 1091500007262 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1091500007263 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1091500007264 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1091500007265 potential frameshift: common BLAST hit: gi|339633091|ref|YP_004724733.1| monooxygenase 1091500007266 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1091500007267 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1091500007268 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1091500007269 NAD(P) binding site [chemical binding]; other site 1091500007270 active site 1091500007271 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 1091500007272 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1091500007273 NAD binding site [chemical binding]; other site 1091500007274 catalytic Zn binding site [ion binding]; other site 1091500007275 substrate binding site [chemical binding]; other site 1091500007276 structural Zn binding site [ion binding]; other site 1091500007277 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1091500007278 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1091500007279 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1091500007280 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1091500007281 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 1091500007282 potential frameshift: common BLAST hit: gi|339633097|ref|YP_004724739.1| chain-fatty-acid-CoA ligase 1091500007283 SPFH domain / Band 7 family; Region: Band_7; pfam01145 1091500007284 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1091500007285 potential frameshift: common BLAST hit: gi|148824284|ref|YP_001289038.1| integral membrane protein 1091500007286 probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841 1091500007287 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1091500007288 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1091500007289 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1091500007290 active site 1091500007291 potential frameshift: common BLAST hit: gi|339633103|ref|YP_004724745.1| transcriptional regulator 1091500007292 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 1091500007293 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1091500007294 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1091500007295 De-etiolated protein 1 Det1; Region: Det1; pfam09737 1091500007296 PemK-like protein; Region: PemK; pfam02452 1091500007297 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1091500007298 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1091500007299 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1091500007300 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1091500007301 SmpB-tmRNA interface; other site 1091500007302 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1091500007303 FtsX-like permease family; Region: FtsX; pfam02687 1091500007304 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1091500007305 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1091500007306 Walker A/P-loop; other site 1091500007307 ATP binding site [chemical binding]; other site 1091500007308 Q-loop/lid; other site 1091500007309 ABC transporter signature motif; other site 1091500007310 Walker B; other site 1091500007311 D-loop; other site 1091500007312 H-loop/switch region; other site 1091500007313 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1091500007314 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1091500007315 peptide chain release factor 2; Validated; Region: prfB; PRK00578 1091500007316 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1091500007317 RF-1 domain; Region: RF-1; pfam00472 1091500007318 ferredoxin-NADP+ reductase; Region: PLN02852 1091500007319 potential frameshift: common BLAST hit: gi|339633115|ref|YP_004724757.1| alkyldihydroxyacetonephosphate synthase 1091500007320 Molybdenum cofactor biosynthesis enzyme [Coenzyme metabolism]; Region: MoaA; COG2896 1091500007321 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1091500007322 FeS/SAM binding site; other site 1091500007323 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1091500007324 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 1091500007325 aromatic arch; other site 1091500007326 DCoH dimer interaction site [polypeptide binding]; other site 1091500007327 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 1091500007328 DCoH tetramer interaction site [polypeptide binding]; other site 1091500007329 substrate binding site [chemical binding]; other site 1091500007330 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1091500007331 trimer interface [polypeptide binding]; other site 1091500007332 dimer interface [polypeptide binding]; other site 1091500007333 putative active site [active] 1091500007334 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1091500007335 MoaE interaction surface [polypeptide binding]; other site 1091500007336 MoeB interaction surface [polypeptide binding]; other site 1091500007337 thiocarboxylated glycine; other site 1091500007338 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1091500007339 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 1091500007340 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1091500007341 nucleoside/Zn binding site; other site 1091500007342 dimer interface [polypeptide binding]; other site 1091500007343 catalytic motif [active] 1091500007344 potential frameshift: common BLAST hit: gi|253800147|ref|YP_003033148.1| transposase 1091500007345 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 1091500007346 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1091500007347 ATP binding site [chemical binding]; other site 1091500007348 substrate interface [chemical binding]; other site 1091500007349 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1091500007350 active site residue [active] 1091500007351 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1091500007352 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1091500007353 active site residue [active] 1091500007354 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1091500007355 active site residue [active] 1091500007356 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 1091500007357 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1091500007358 MoaE homodimer interface [polypeptide binding]; other site 1091500007359 MoaD interaction [polypeptide binding]; other site 1091500007360 active site residues [active] 1091500007361 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091500007362 S-adenosylmethionine binding site [chemical binding]; other site 1091500007363 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1091500007364 Cytochrome P450; Region: p450; cl12078 1091500007365 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1091500007366 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1091500007367 PPE family; Region: PPE; pfam00823 1091500007368 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1091500007369 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 1091500007370 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1091500007371 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1091500007372 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1091500007373 dimer interface [polypeptide binding]; other site 1091500007374 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1091500007375 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1091500007376 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1091500007377 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1091500007378 Histidine kinase; Region: HisKA_3; pfam07730 1091500007379 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1091500007380 ATP binding site [chemical binding]; other site 1091500007381 Mg2+ binding site [ion binding]; other site 1091500007382 G-X-G motif; other site 1091500007383 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1091500007384 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1091500007385 DNA binding residues [nucleotide binding] 1091500007386 dimerization interface [polypeptide binding]; other site 1091500007387 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1091500007388 PPE family; Region: PPE; pfam00823 1091500007389 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1091500007390 PPE family; Region: PPE; pfam00823 1091500007391 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1091500007392 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1091500007393 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 1091500007394 active site 1091500007395 AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337 1091500007396 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1091500007397 FeS/SAM binding site; other site 1091500007398 potential frameshift: common BLAST hit: gi|340628115|ref|YP_004746567.1| putative acyl-CoA dehydrogenase FADE24 1091500007399 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1091500007400 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1091500007401 active site 1091500007402 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1091500007403 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 1091500007404 NAD(P) binding site [chemical binding]; other site 1091500007405 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091500007406 active site 1091500007407 phosphorylation site [posttranslational modification] 1091500007408 intermolecular recognition site; other site 1091500007409 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1091500007410 PPE family; Region: PPE; pfam00823 1091500007411 NADH dehydrogenase subunit A; Validated; Region: PRK07928 1091500007412 NADH dehydrogenase subunit B; Validated; Region: PRK06411 1091500007413 NADH dehydrogenase subunit C; Provisional; Region: PRK07785 1091500007414 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 1091500007415 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 1091500007416 NADH dehydrogenase subunit D; Validated; Region: PRK06075 1091500007417 NADH dehydrogenase subunit E; Validated; Region: PRK07539 1091500007418 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1091500007419 putative dimer interface [polypeptide binding]; other site 1091500007420 [2Fe-2S] cluster binding site [ion binding]; other site 1091500007421 potential frameshift: common BLAST hit: gi|340628126|ref|YP_004746578.1| putative NADH dehydrogenase I subunit F NuoF 1091500007422 potential frameshift: common BLAST hit: gi|339633158|ref|YP_004724800.1| NADH dehydrogenase I subunit G 1091500007423 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1091500007424 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 1091500007425 4Fe-4S binding domain; Region: Fer4; pfam00037 1091500007426 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 1091500007427 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 1091500007428 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 1091500007429 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1091500007430 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1091500007431 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 1091500007432 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1091500007433 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1091500007434 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1091500007435 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1091500007436 PPE family; Region: PPE; pfam00823 1091500007437 potential frameshift: common BLAST hit: gi|339633168|ref|YP_004724810.1| TetR family transcriptional regulator 1091500007438 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1091500007439 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1091500007440 [2Fe-2S] cluster binding site [ion binding]; other site 1091500007441 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_1; cd08885 1091500007442 putative alpha subunit interface [polypeptide binding]; other site 1091500007443 putative active site [active] 1091500007444 putative substrate binding site [chemical binding]; other site 1091500007445 Fe binding site [ion binding]; other site 1091500007446 potential frameshift: common BLAST hit: gi|340628141|ref|YP_004746593.1| putative methanol dehydrogenase transcriptional regulatory protein 1091500007447 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1091500007448 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1091500007449 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 1091500007450 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1091500007451 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1091500007452 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1091500007453 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1091500007454 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1091500007455 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1091500007456 short chain dehydrogenase; Validated; Region: PRK08264 1091500007457 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1091500007458 NAD(P) binding site [chemical binding]; other site 1091500007459 active site 1091500007460 amidase; Provisional; Region: PRK06170 1091500007461 Amidase; Region: Amidase; pfam01425 1091500007462 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1091500007463 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1091500007464 TAP-like protein; Region: Abhydrolase_4; pfam08386 1091500007465 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1091500007466 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 1091500007467 AAA domain; Region: AAA_14; pfam13173 1091500007468 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1091500007469 putative active site [active] 1091500007470 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1091500007471 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4683 1091500007472 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1091500007473 non-specific DNA binding site [nucleotide binding]; other site 1091500007474 salt bridge; other site 1091500007475 sequence-specific DNA binding site [nucleotide binding]; other site 1091500007476 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1091500007477 Transposase; Region: HTH_Tnp_1; cl17663 1091500007478 putative transposase OrfB; Reviewed; Region: PHA02517 1091500007479 HTH-like domain; Region: HTH_21; pfam13276 1091500007480 Integrase core domain; Region: rve; pfam00665 1091500007481 Integrase core domain; Region: rve_3; pfam13683 1091500007482 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1091500007483 Transposase; Region: HTH_Tnp_1; cl17663 1091500007484 putative transposase OrfB; Reviewed; Region: PHA02517 1091500007485 HTH-like domain; Region: HTH_21; pfam13276 1091500007486 Integrase core domain; Region: rve; pfam00665 1091500007487 Integrase core domain; Region: rve_3; pfam13683 1091500007488 RES domain; Region: RES; pfam08808 1091500007489 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1091500007490 Helix-turn-helix domain; Region: HTH_38; pfam13936 1091500007491 Integrase core domain; Region: rve; pfam00665 1091500007492 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1091500007493 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1091500007494 hypothetical protein; Validated; Region: PRK00068 1091500007495 Uncharacterized conserved protein [Function unknown]; Region: COG1615 1091500007496 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 1091500007497 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 1091500007498 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 1091500007499 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1091500007500 Uncharacterized conserved protein [Function unknown]; Region: COG5282 1091500007501 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 1091500007502 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 1091500007503 ABC1 family; Region: ABC1; pfam03109 1091500007504 Phosphotransferase enzyme family; Region: APH; pfam01636 1091500007505 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1091500007506 active site 1091500007507 ATP binding site [chemical binding]; other site 1091500007508 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1091500007509 Part of AAA domain; Region: AAA_19; pfam13245 1091500007510 Family description; Region: UvrD_C_2; pfam13538 1091500007511 HRDC domain; Region: HRDC; pfam00570 1091500007512 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1091500007513 catalytic residues [active] 1091500007514 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 1091500007515 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 1091500007516 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 1091500007517 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1091500007518 putative NADH binding site [chemical binding]; other site 1091500007519 putative active site [active] 1091500007520 nudix motif; other site 1091500007521 putative metal binding site [ion binding]; other site 1091500007522 potential frameshift: common BLAST hit: gi|253800236|ref|YP_003033237.1| transmembrane cation transporter 1091500007523 potential frameshift: common BLAST hit: gi|339633208|ref|YP_004724850.1| ATP-dependent DNA helicase 1091500007524 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1091500007525 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1091500007526 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 1091500007527 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1091500007528 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1091500007529 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1091500007530 active site 1091500007531 DNA binding site [nucleotide binding] 1091500007532 TIGR02569 family protein; Region: TIGR02569_actnb 1091500007533 potential frameshift: common BLAST hit: gi|339633213|ref|YP_004724855.1| molybdenum cofactor biosynthesis protein B 1091500007534 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 1091500007535 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1091500007536 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1091500007537 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 1091500007538 tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like; Region: MiaE_2; pfam13794 1091500007539 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1091500007540 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1091500007541 ATP binding site [chemical binding]; other site 1091500007542 Mg++ binding site [ion binding]; other site 1091500007543 motif III; other site 1091500007544 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1091500007545 nucleotide binding region [chemical binding]; other site 1091500007546 ATP-binding site [chemical binding]; other site 1091500007547 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1091500007548 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1091500007549 P-loop; other site 1091500007550 Magnesium ion binding site [ion binding]; other site 1091500007551 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1091500007552 Magnesium ion binding site [ion binding]; other site 1091500007553 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1091500007554 catalytic core [active] 1091500007555 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 1091500007556 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1091500007557 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1091500007558 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1091500007559 Transcription factor WhiB; Region: Whib; pfam02467 1091500007560 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 1091500007561 PAS domain S-box; Region: sensory_box; TIGR00229 1091500007562 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1091500007563 Histidine kinase; Region: HisKA_2; pfam07568 1091500007564 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1091500007565 ATP binding site [chemical binding]; other site 1091500007566 Mg2+ binding site [ion binding]; other site 1091500007567 G-X-G motif; other site 1091500007568 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1091500007569 carboxyltransferase (CT) interaction site; other site 1091500007570 biotinylation site [posttranslational modification]; other site 1091500007571 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; TIGR03988 1091500007572 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 1091500007573 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1091500007574 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1091500007575 DNA binding residues [nucleotide binding] 1091500007576 potential frameshift: common BLAST hit: gi|339633233|ref|YP_004724875.1| iron-regulated short-chain dehydrogenase/reductase 1091500007577 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 1091500007578 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 1091500007579 putative deacylase active site [active] 1091500007580 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1091500007581 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1091500007582 Coenzyme A binding pocket [chemical binding]; other site 1091500007583 Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases; Region: APH_ChoK_like_1; cd05155 1091500007584 Phosphotransferase enzyme family; Region: APH; pfam01636 1091500007585 putative active site [active] 1091500007586 putative substrate binding site [chemical binding]; other site 1091500007587 ATP binding site [chemical binding]; other site 1091500007588 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1091500007589 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1091500007590 hinge; other site 1091500007591 active site 1091500007592 Predicted GTPases [General function prediction only]; Region: COG1162 1091500007593 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1091500007594 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1091500007595 GTP/Mg2+ binding site [chemical binding]; other site 1091500007596 G4 box; other site 1091500007597 G5 box; other site 1091500007598 G1 box; other site 1091500007599 Switch I region; other site 1091500007600 G2 box; other site 1091500007601 G3 box; other site 1091500007602 Switch II region; other site 1091500007603 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1091500007604 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 1091500007605 putative di-iron ligands [ion binding]; other site 1091500007606 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 1091500007607 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1091500007608 FAD binding pocket [chemical binding]; other site 1091500007609 FAD binding motif [chemical binding]; other site 1091500007610 phosphate binding motif [ion binding]; other site 1091500007611 beta-alpha-beta structure motif; other site 1091500007612 NAD binding pocket [chemical binding]; other site 1091500007613 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1091500007614 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1091500007615 catalytic loop [active] 1091500007616 iron binding site [ion binding]; other site 1091500007617 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 1091500007618 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1091500007619 potential frameshift: common BLAST hit: gi|253800278|ref|YP_003033279.1| membrane transporter 1091500007620 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 1091500007621 TrkA-C domain; Region: TrkA_C; pfam02080 1091500007622 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1091500007623 potential frameshift: common BLAST hit: gi|31794419|ref|NP_856912.1| transmembrane transport protein 1091500007624 potential frameshift: common BLAST hit: gi|340628219|ref|YP_004746671.1| putative preprotein translocase SECA1 1 subunit 1091500007625 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1091500007626 30S subunit binding site; other site 1091500007627 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1091500007628 active site 1091500007629 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 1091500007630 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1091500007631 potential frameshift: common BLAST hit: gi|253800286|ref|YP_003033287.1| lipoprotein LpqB 1091500007632 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1091500007633 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1091500007634 dimerization interface [polypeptide binding]; other site 1091500007635 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1091500007636 dimer interface [polypeptide binding]; other site 1091500007637 phosphorylation site [posttranslational modification] 1091500007638 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1091500007639 ATP binding site [chemical binding]; other site 1091500007640 Mg2+ binding site [ion binding]; other site 1091500007641 G-X-G motif; other site 1091500007642 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1091500007643 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091500007644 active site 1091500007645 phosphorylation site [posttranslational modification] 1091500007646 intermolecular recognition site; other site 1091500007647 dimerization interface [polypeptide binding]; other site 1091500007648 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1091500007649 DNA binding site [nucleotide binding] 1091500007650 thymidylate kinase; Provisional; Region: PRK13975; cl17243 1091500007651 potential frameshift: common BLAST hit: gi|340628226|ref|YP_004746678.1| putative adenosylhomocysteinase SAHH 1091500007652 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1091500007653 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 1091500007654 Rubredoxin [Energy production and conversion]; Region: COG1773 1091500007655 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1091500007656 iron binding site [ion binding]; other site 1091500007657 Rubredoxin [Energy production and conversion]; Region: COG1773 1091500007658 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1091500007659 iron binding site [ion binding]; other site 1091500007660 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 1091500007661 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1091500007662 Di-iron ligands [ion binding]; other site 1091500007663 potential frameshift: common BLAST hit: gi|340628231|ref|YP_004746683.1| putative cationic amino acid transport integral membrane protein 1091500007664 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1091500007665 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1091500007666 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1091500007667 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1091500007668 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1091500007669 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 1091500007670 active site 1091500007671 substrate binding site [chemical binding]; other site 1091500007672 metal binding site [ion binding]; metal-binding site 1091500007673 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 1091500007674 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 1091500007675 Transcription factor WhiB; Region: Whib; pfam02467 1091500007676 potential frameshift: common BLAST hit: gi|340628239|ref|YP_004746691.1| putative F420 biosynthesis protein FBIA 1091500007677 potential frameshift: common BLAST hit: gi|340628240|ref|YP_004746692.1| putative F420 biosynthesis protein FBIB 1091500007678 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 1091500007679 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1091500007680 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 1091500007681 active site 1091500007682 Substrate binding site; other site 1091500007683 Mg++ binding site; other site 1091500007684 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1091500007685 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1091500007686 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1091500007687 Probable Catalytic site; other site 1091500007688 metal-binding site 1091500007689 dTDP-4-dehydrorhamnose reductase; Region: rmlD; TIGR01214 1091500007690 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1091500007691 NADP binding site [chemical binding]; other site 1091500007692 active site 1091500007693 putative substrate binding site [chemical binding]; other site 1091500007694 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1091500007695 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1091500007696 TIGR03089 family protein; Region: TIGR03089 1091500007697 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 1091500007698 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1091500007699 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1091500007700 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1091500007701 active site 1091500007702 motif I; other site 1091500007703 motif II; other site 1091500007704 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1091500007705 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1091500007706 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1091500007707 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1091500007708 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1091500007709 Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: CynT; COG0288 1091500007710 active site clefts [active] 1091500007711 zinc binding site [ion binding]; other site 1091500007712 dimer interface [polypeptide binding]; other site 1091500007713 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1091500007714 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 1091500007715 FAD binding site [chemical binding]; other site 1091500007716 homotetramer interface [polypeptide binding]; other site 1091500007717 substrate binding pocket [chemical binding]; other site 1091500007718 catalytic base [active] 1091500007719 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1091500007720 potential frameshift: common BLAST hit: gi|339633286|ref|YP_004724928.1| phosphoribosylaminoimidazole carboxylase ATPase subunit 1091500007721 Predicted membrane protein [Function unknown]; Region: COG2246 1091500007722 GtrA-like protein; Region: GtrA; pfam04138 1091500007723 Bacterial PH domain; Region: DUF304; pfam03703 1091500007724 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1091500007725 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1091500007726 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1091500007727 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1091500007728 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1091500007729 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1091500007730 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 1091500007731 Maf-like protein; Region: Maf; pfam02545 1091500007732 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1091500007733 active site 1091500007734 dimer interface [polypeptide binding]; other site 1091500007735 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1091500007736 active site residue [active] 1091500007737 Fe-S metabolism associated domain; Region: SufE; pfam02657 1091500007738 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1091500007739 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1091500007740 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1091500007741 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1091500007742 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1091500007743 carboxyltransferase (CT) interaction site; other site 1091500007744 biotinylation site [posttranslational modification]; other site 1091500007745 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122 1091500007746 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1091500007747 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1091500007748 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1091500007749 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1091500007750 L-lysine aminotransferase; Provisional; Region: PRK08297 1091500007751 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1091500007752 inhibitor-cofactor binding pocket; inhibition site 1091500007753 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1091500007754 catalytic residue [active] 1091500007755 potential frameshift: common BLAST hit: gi|375297563|ref|YP_005101830.1| transcriptional regulator, asnC-family 1091500007756 AsnC family; Region: AsnC_trans_reg; pfam01037 1091500007757 putative DNA binding site [nucleotide binding]; other site 1091500007758 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1091500007759 putative Zn2+ binding site [ion binding]; other site 1091500007760 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 1091500007761 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1091500007762 tetrameric interface [polypeptide binding]; other site 1091500007763 NAD binding site [chemical binding]; other site 1091500007764 catalytic residues [active] 1091500007765 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1091500007766 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1091500007767 CRISPR-associated helicase Cas3, subtype CYANO; Region: cas3_cyano; TIGR03158 1091500007768 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1091500007769 ATP binding site [chemical binding]; other site 1091500007770 putative Mg++ binding site [ion binding]; other site 1091500007771 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1091500007772 nucleotide binding region [chemical binding]; other site 1091500007773 ATP-binding site [chemical binding]; other site 1091500007774 potential frameshift: common BLAST hit: gi|253800339|ref|YP_003033340.1| ATP-dependent helicase lhr 1091500007775 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1091500007776 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 1091500007777 putative DNA binding site [nucleotide binding]; other site 1091500007778 catalytic residue [active] 1091500007779 putative H2TH interface [polypeptide binding]; other site 1091500007780 putative catalytic residues [active] 1091500007781 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1091500007782 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 1091500007783 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1091500007784 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1091500007785 Sulfatase; Region: Sulfatase; cl17466 1091500007786 Pentraxins are plasma proteins characterized by their pentameric discoid assembly and their Ca2+ dependent ligand binding, such as Serum amyloid P component (SAP) and C-reactive Protein (CRP), which are cytokine-inducible acute-phase proteins implicated...; Region: PTX; cl00102 1091500007787 potential frameshift: common BLAST hit: gi|339633307|ref|YP_004724949.1| arylsulfatase 1091500007788 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1091500007789 PhoU domain; Region: PhoU; pfam01895 1091500007790 PhoU domain; Region: PhoU; pfam01895 1091500007791 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1091500007792 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 1091500007793 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1091500007794 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1091500007795 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1091500007796 putative active site pocket [active] 1091500007797 dimerization interface [polypeptide binding]; other site 1091500007798 putative catalytic residue [active] 1091500007799 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1091500007800 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 1091500007801 metal binding site [ion binding]; metal-binding site 1091500007802 putative dimer interface [polypeptide binding]; other site 1091500007803 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 1091500007804 amidohydrolase; Region: amidohydrolases; TIGR01891 1091500007805 metal binding site [ion binding]; metal-binding site 1091500007806 purine nucleoside phosphorylase; Provisional; Region: PRK08202 1091500007807 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 1091500007808 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1091500007809 active site 1091500007810 substrate binding site [chemical binding]; other site 1091500007811 metal binding site [ion binding]; metal-binding site 1091500007812 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1091500007813 active site 1091500007814 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1091500007815 potential frameshift: common BLAST hit: gi|15842903|ref|NP_337940.1| alpha/beta hydrolase 1091500007816 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1091500007817 adenosine deaminase; Provisional; Region: PRK09358 1091500007818 active site 1091500007819 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 1091500007820 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1091500007821 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1091500007822 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 1091500007823 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1091500007824 active site 1091500007825 catalytic motif [active] 1091500007826 Zn binding site [ion binding]; other site 1091500007827 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 1091500007828 putative Iron-sulfur protein interface [polypeptide binding]; other site 1091500007829 putative proximal heme binding site [chemical binding]; other site 1091500007830 putative SdhC-like subunit interface [polypeptide binding]; other site 1091500007831 putative distal heme binding site [chemical binding]; other site 1091500007832 potential frameshift: common BLAST hit: gi|339633326|ref|YP_004724968.1| succinate dehydrogenase 1091500007833 potential frameshift: common BLAST hit: gi|339633326|ref|YP_004724968.1| succinate dehydrogenase 1091500007834 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1091500007835 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1091500007836 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 1091500007837 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 1091500007838 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1091500007839 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091500007840 S-adenosylmethionine binding site [chemical binding]; other site 1091500007841 potential frameshift: common BLAST hit: gi|253800368|ref|YP_003033369.1| moaD-moaE fusion protein moaX 1091500007842 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1091500007843 trimer interface [polypeptide binding]; other site 1091500007844 dimer interface [polypeptide binding]; other site 1091500007845 putative active site [active] 1091500007846 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1091500007847 Transposase; Region: HTH_Tnp_1; cl17663 1091500007848 putative transposase OrfB; Reviewed; Region: PHA02517 1091500007849 HTH-like domain; Region: HTH_21; pfam13276 1091500007850 Integrase core domain; Region: rve; pfam00665 1091500007851 Integrase core domain; Region: rve_3; pfam13683 1091500007852 potential frameshift: common BLAST hit: gi|15840209|ref|NP_335246.1| IS1547 transposase 1091500007853 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1091500007854 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1091500007855 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 1091500007856 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1091500007857 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1091500007858 DNA binding residues [nucleotide binding] 1091500007859 SnoaL-like domain; Region: SnoaL_2; pfam12680 1091500007860 potential frameshift: common BLAST hit: gi|339633341|ref|YP_004724983.1| aminotransferase 1091500007861 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1091500007862 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1091500007863 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 1091500007864 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1091500007865 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1091500007866 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1091500007867 active site 1091500007868 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1091500007869 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 1091500007870 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1091500007871 DNA binding residues [nucleotide binding] 1091500007872 dimer interface [polypeptide binding]; other site 1091500007873 metal binding site [ion binding]; metal-binding site 1091500007874 inner membrane protein YhjD; Region: TIGR00766 1091500007875 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1091500007876 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1091500007877 active site 1091500007878 HIGH motif; other site 1091500007879 dimer interface [polypeptide binding]; other site 1091500007880 KMSKS motif; other site 1091500007881 isocitrate dehydrogenase; Validated; Region: PRK08299 1091500007882 potential frameshift: common BLAST hit: gi|340628324|ref|YP_004746776.1| putative O-acetylhomoserine sulfhydrylase METC 1091500007883 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 1091500007884 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 1091500007885 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1091500007886 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091500007887 S-adenosylmethionine binding site [chemical binding]; other site 1091500007888 potential frameshift: common BLAST hit: gi|224991768|ref|YP_002646457.1| PPE family protein 1091500007889 potential frameshift: common BLAST hit: gi|224991768|ref|YP_002646457.1| PPE family protein 1091500007890 potential frameshift: common BLAST hit: gi|339633354|ref|YP_004724996.1| PPE family protein 1091500007891 PPE family; Region: PPE; pfam00823 1091500007892 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1091500007893 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1091500007894 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1091500007895 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1091500007896 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1091500007897 PE family; Region: PE; pfam00934 1091500007898 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 1091500007899 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1091500007900 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1091500007901 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 1091500007902 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 1091500007903 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1091500007904 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1091500007905 homodimer interface [polypeptide binding]; other site 1091500007906 NADP binding site [chemical binding]; other site 1091500007907 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 1091500007908 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 1091500007909 potential frameshift: common BLAST hit: gi|340628341|ref|YP_004746793.1| putative oxidoreductase 1091500007910 potential frameshift: common BLAST hit: gi|340628341|ref|YP_004746793.1| putative oxidoreductase 1091500007911 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1091500007912 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1091500007913 phosphopeptide binding site; other site 1091500007914 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1091500007915 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1091500007916 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1091500007917 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1091500007918 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1091500007919 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 1091500007920 G1 box; other site 1091500007921 GTP/Mg2+ binding site [chemical binding]; other site 1091500007922 G2 box; other site 1091500007923 Switch I region; other site 1091500007924 G3 box; other site 1091500007925 Switch II region; other site 1091500007926 G4 box; other site 1091500007927 G5 box; other site 1091500007928 Protein of unknown function (DUF742); Region: DUF742; pfam05331 1091500007929 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 1091500007930 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1091500007931 PE family; Region: PE; pfam00934 1091500007932 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 1091500007933 FMN binding site [chemical binding]; other site 1091500007934 dimer interface [polypeptide binding]; other site 1091500007935 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1091500007936 potential frameshift: common BLAST hit: gi|339633378|ref|YP_004725020.1| DNA polymerase III subunit alpha 1091500007937 potential frameshift: common BLAST hit: gi|339633378|ref|YP_004725020.1| DNA polymerase III subunit alpha 1091500007938 potential frameshift: common BLAST hit: gi|224991794|ref|YP_002646483.1| error-prone DNA polymerase 1091500007939 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1091500007940 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1091500007941 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1091500007942 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 1091500007943 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1091500007944 active site 1091500007945 motif I; other site 1091500007946 motif II; other site 1091500007947 PE family; Region: PE; pfam00934 1091500007948 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1091500007949 substrate binding site [chemical binding]; other site 1091500007950 oxyanion hole (OAH) forming residues; other site 1091500007951 trimer interface [polypeptide binding]; other site 1091500007952 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 1091500007953 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1091500007954 Amidase; Region: Amidase; pfam01425 1091500007955 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1091500007956 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1091500007957 motif II; other site 1091500007958 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 1091500007959 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 1091500007960 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1091500007961 TPP-binding site [chemical binding]; other site 1091500007962 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 1091500007963 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1091500007964 PYR/PP interface [polypeptide binding]; other site 1091500007965 dimer interface [polypeptide binding]; other site 1091500007966 TPP binding site [chemical binding]; other site 1091500007967 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1091500007968 putative transposase OrfB; Reviewed; Region: PHA02517 1091500007969 HTH-like domain; Region: HTH_21; pfam13276 1091500007970 Integrase core domain; Region: rve; pfam00665 1091500007971 Integrase core domain; Region: rve_3; pfam13683 1091500007972 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1091500007973 Transposase; Region: HTH_Tnp_1; cl17663 1091500007974 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1091500007975 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1091500007976 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1091500007977 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1091500007978 substrate binding pocket [chemical binding]; other site 1091500007979 chain length determination region; other site 1091500007980 substrate-Mg2+ binding site; other site 1091500007981 catalytic residues [active] 1091500007982 aspartate-rich region 1; other site 1091500007983 active site lid residues [active] 1091500007984 aspartate-rich region 2; other site 1091500007985 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 1091500007986 putative active site [active] 1091500007987 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1091500007988 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 1091500007989 Transposase domain (DUF772); Region: DUF772; pfam05598 1091500007990 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 1091500007991 PE family; Region: PE; pfam00934 1091500007992 enoyl-CoA hydratase; Region: PLN02864 1091500007993 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1091500007994 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 1091500007995 dimer interaction site [polypeptide binding]; other site 1091500007996 substrate-binding tunnel; other site 1091500007997 active site 1091500007998 catalytic site [active] 1091500007999 substrate binding site [chemical binding]; other site 1091500008000 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1091500008001 short chain dehydrogenase; Provisional; Region: PRK07201 1091500008002 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 1091500008003 putative NAD(P) binding site [chemical binding]; other site 1091500008004 active site 1091500008005 putative substrate binding site [chemical binding]; other site 1091500008006 classical (c) SDRs; Region: SDR_c; cd05233 1091500008007 NAD(P) binding site [chemical binding]; other site 1091500008008 active site 1091500008009 potential frameshift: common BLAST hit: gi|253800438|ref|YP_003033439.1| cyclopropane-fatty-acyl-phospholipid synthase 1 cmaA1 1091500008010 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 1091500008011 active site 1091500008012 DNA Polymerase Y-family; Region: PolY_like; cd03468 1091500008013 DNA binding site [nucleotide binding] 1091500008014 GMP synthase; Reviewed; Region: guaA; PRK00074 1091500008015 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1091500008016 AMP/PPi binding site [chemical binding]; other site 1091500008017 candidate oxyanion hole; other site 1091500008018 catalytic triad [active] 1091500008019 potential glutamine specificity residues [chemical binding]; other site 1091500008020 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1091500008021 ATP Binding subdomain [chemical binding]; other site 1091500008022 Ligand Binding sites [chemical binding]; other site 1091500008023 Dimerization subdomain; other site 1091500008024 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 1091500008025 active site lid residues [active] 1091500008026 substrate binding pocket [chemical binding]; other site 1091500008027 catalytic residues [active] 1091500008028 substrate-Mg2+ binding site; other site 1091500008029 aspartate-rich region 1; other site 1091500008030 aspartate-rich region 2; other site 1091500008031 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1091500008032 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1091500008033 substrate binding pocket [chemical binding]; other site 1091500008034 chain length determination region; other site 1091500008035 substrate-Mg2+ binding site; other site 1091500008036 catalytic residues [active] 1091500008037 aspartate-rich region 1; other site 1091500008038 active site lid residues [active] 1091500008039 aspartate-rich region 2; other site 1091500008040 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1091500008041 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1091500008042 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 1091500008043 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 1091500008044 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1091500008045 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1091500008046 inhibitor-cofactor binding pocket; inhibition site 1091500008047 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1091500008048 catalytic residue [active] 1091500008049 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 1091500008050 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1091500008051 hypothetical protein; Provisional; Region: PRK07579 1091500008052 Formyltransferase, catalytic core domain; Region: FMT_core; cd08369 1091500008053 active site 1091500008054 cosubstrate binding site; other site 1091500008055 substrate binding site [chemical binding]; other site 1091500008056 catalytic site [active] 1091500008057 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1091500008058 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1091500008059 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1091500008060 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1091500008061 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1091500008062 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 1091500008063 putative active site [active] 1091500008064 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1091500008065 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1091500008066 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1091500008067 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 1091500008068 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1091500008069 phosphate binding site [ion binding]; other site 1091500008070 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1091500008071 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1091500008072 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1091500008073 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1091500008074 active site 1091500008075 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 1091500008076 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1091500008077 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1091500008078 DNA binding residues [nucleotide binding] 1091500008079 Transcription factor WhiB; Region: Whib; pfam02467 1091500008080 potential frameshift: common BLAST hit: gi|340628395|ref|YP_004746847.1| 60 KDA chaperonin 1 1091500008081 chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I...; Region: chaperonin_like; cl02777 1091500008082 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1091500008083 oligomerisation interface [polypeptide binding]; other site 1091500008084 mobile loop; other site 1091500008085 roof hairpin; other site 1091500008086 UGMP family protein; Validated; Region: PRK09604 1091500008087 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1091500008088 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1091500008089 Coenzyme A binding pocket [chemical binding]; other site 1091500008090 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 1091500008091 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; pfam02367 1091500008092 alanine racemase; Reviewed; Region: alr; PRK00053 1091500008093 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1091500008094 active site 1091500008095 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1091500008096 dimer interface [polypeptide binding]; other site 1091500008097 substrate binding site [chemical binding]; other site 1091500008098 catalytic residues [active] 1091500008099 potential frameshift: common BLAST hit: gi|339633430|ref|YP_004725072.1| PPE family protein 1091500008100 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1091500008101 PPE family; Region: PPE; pfam00823 1091500008102 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 1091500008103 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1091500008104 Walker A motif; other site 1091500008105 ATP binding site [chemical binding]; other site 1091500008106 Walker B motif; other site 1091500008107 arginine finger; other site 1091500008108 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1091500008109 PPE family; Region: PPE; pfam00823 1091500008110 potential frameshift: common BLAST hit: gi|339633435|ref|YP_004725077.1| transposase 1091500008111 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1091500008112 MULE transposase domain; Region: MULE; pfam10551 1091500008113 potential frameshift: common BLAST hit: gi|339633437|ref|YP_004725079.1| glutamate decarboxylase GADB 1091500008114 Uncharacterized conserved protein [Function unknown]; Region: COG0062 1091500008115 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1091500008116 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1091500008117 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1091500008118 glutaminase active site [active] 1091500008119 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1091500008120 dimer interface [polypeptide binding]; other site 1091500008121 active site 1091500008122 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1091500008123 dimer interface [polypeptide binding]; other site 1091500008124 active site 1091500008125 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 1091500008126 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 1091500008127 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1091500008128 active site 1091500008129 substrate binding site [chemical binding]; other site 1091500008130 metal binding site [ion binding]; metal-binding site 1091500008131 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1091500008132 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1091500008133 23S rRNA interface [nucleotide binding]; other site 1091500008134 L3 interface [polypeptide binding]; other site 1091500008135 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1091500008136 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1091500008137 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 1091500008138 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 1091500008139 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1091500008140 active site 1091500008141 catalytic residues [active] 1091500008142 Protein of unknown function (DUF690); Region: DUF690; pfam05108 1091500008143 Cutinase; Region: Cutinase; pfam01083 1091500008144 Cutinase; Region: Cutinase; pfam01083 1091500008145 potential frameshift: common BLAST hit: gi|224991870|ref|YP_002646559.1| transmembrane protein 1091500008146 Pseudouridylate synthase [Translation, ribosomal structure and biogenesis]; Region: TruA; COG0101 1091500008147 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1091500008148 dimerization interface 3.5A [polypeptide binding]; other site 1091500008149 active site 1091500008150 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1091500008151 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1091500008152 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1091500008153 alphaNTD - beta interaction site [polypeptide binding]; other site 1091500008154 alphaNTD homodimer interface [polypeptide binding]; other site 1091500008155 alphaNTD - beta' interaction site [polypeptide binding]; other site 1091500008156 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1091500008157 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1091500008158 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1091500008159 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1091500008160 RNA binding surface [nucleotide binding]; other site 1091500008161 30S ribosomal protein S11; Validated; Region: PRK05309 1091500008162 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1091500008163 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1091500008164 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 1091500008165 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1091500008166 rRNA binding site [nucleotide binding]; other site 1091500008167 predicted 30S ribosome binding site; other site 1091500008168 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 1091500008169 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 1091500008170 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1091500008171 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1091500008172 NAD binding site [chemical binding]; other site 1091500008173 substrate binding site [chemical binding]; other site 1091500008174 homodimer interface [polypeptide binding]; other site 1091500008175 active site 1091500008176 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 1091500008177 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1091500008178 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1091500008179 extended (e) SDRs; Region: SDR_e; cd08946 1091500008180 NAD(P) binding site [chemical binding]; other site 1091500008181 active site 1091500008182 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 1091500008183 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 1091500008184 active site 1091500008185 catalytic residues [active] 1091500008186 metal binding site [ion binding]; metal-binding site 1091500008187 potential frameshift: common BLAST hit: gi|253800515|ref|YP_003033516.1| acetolactate synthase large subunit ilvB2 1091500008188 potential frameshift: common BLAST hit: gi|253800515|ref|YP_003033516.1| acetolactate synthase large subunit ilvB2 1091500008189 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 1091500008190 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1091500008191 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1091500008192 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1091500008193 Transposase; Region: HTH_Tnp_1; cl17663 1091500008194 putative transposase OrfB; Reviewed; Region: PHA02517 1091500008195 HTH-like domain; Region: HTH_21; pfam13276 1091500008196 Integrase core domain; Region: rve; pfam00665 1091500008197 Integrase core domain; Region: rve_3; pfam13683 1091500008198 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1091500008199 putative substrate translocation pore; other site 1091500008200 PE family; Region: PE; pfam00934 1091500008201 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1091500008202 PPE family; Region: PPE; pfam00823 1091500008203 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1091500008204 patatin-related protein; Region: TIGR03607 1091500008205 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1091500008206 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1091500008207 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 1091500008208 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 1091500008209 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 1091500008210 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 1091500008211 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1091500008212 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1091500008213 short chain dehydrogenase; Provisional; Region: PRK05875 1091500008214 classical (c) SDRs; Region: SDR_c; cd05233 1091500008215 NAD(P) binding site [chemical binding]; other site 1091500008216 active site 1091500008217 Predicted membrane protein [Function unknown]; Region: COG2259 1091500008218 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1091500008219 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1091500008220 substrate binding pocket [chemical binding]; other site 1091500008221 Predicted transcriptional regulators [Transcription]; Region: COG1695 1091500008222 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1091500008223 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 1091500008224 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 1091500008225 active site 1091500008226 homotetramer interface [polypeptide binding]; other site 1091500008227 potential frameshift: common BLAST hit: gi|340628462|ref|YP_004746914.1| MCE-family protein MCE4F 1091500008228 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1091500008229 mce related protein; Region: MCE; pfam02470 1091500008230 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1091500008231 mce related protein; Region: MCE; pfam02470 1091500008232 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1091500008233 mce related protein; Region: MCE; pfam02470 1091500008234 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1091500008235 mce related protein; Region: MCE; pfam02470 1091500008236 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1091500008237 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1091500008238 Permease; Region: Permease; pfam02405 1091500008239 Permease; Region: Permease; pfam02405 1091500008240 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07792 1091500008241 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1091500008242 NAD(P) binding site [chemical binding]; other site 1091500008243 active site 1091500008244 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1091500008245 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 1091500008246 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1091500008247 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 1091500008248 FAD binding site [chemical binding]; other site 1091500008249 substrate binding site [chemical binding]; other site 1091500008250 catalytic base [active] 1091500008251 potential frameshift: common BLAST hit: gi|339633508|ref|YP_004725150.1| acyl-CoA dehydrogenase 1091500008252 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1091500008253 active site 1091500008254 CoA binding site [chemical binding]; other site 1091500008255 AMP binding site [chemical binding]; other site 1091500008256 potential frameshift: common BLAST hit: gi|253800549|ref|YP_003033550.1| PE-PGRS family protein 1091500008257 PE family; Region: PE; pfam00934 1091500008258 potential frameshift: common BLAST hit: gi|339633511|ref|YP_004725153.1| acetohydroxyacid synthase 1091500008259 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 1091500008260 PE family; Region: PE; pfam00934 1091500008261 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1091500008262 CoA binding site [chemical binding]; other site 1091500008263 PE family; Region: PE; pfam00934 1091500008264 potential frameshift: common BLAST hit: gi|339633515|ref|YP_004725157.1| fatty-acid-CoA ligase 1091500008265 enoyl-CoA hydratase; Provisional; Region: PRK07799 1091500008266 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1091500008267 substrate binding site [chemical binding]; other site 1091500008268 oxyanion hole (OAH) forming residues; other site 1091500008269 trimer interface [polypeptide binding]; other site 1091500008270 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1091500008271 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1091500008272 Cytochrome P450; Region: p450; cl12078 1091500008273 Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314 1091500008274 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1091500008275 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 1091500008276 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1091500008277 DUF35 OB-fold domain; Region: DUF35; pfam01796 1091500008278 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1091500008279 DUF35 OB-fold domain; Region: DUF35; pfam01796 1091500008280 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1091500008281 active site 1091500008282 potential frameshift: common BLAST hit: gi|340628487|ref|YP_004746939.1| putative lipid carrier protein or keto acyl-CoA thiolase LTP3 1091500008283 NHL repeat; Region: NHL; pfam01436 1091500008284 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1091500008285 NHL repeat; Region: NHL; pfam01436 1091500008286 NHL repeat; Region: NHL; pfam01436 1091500008287 NHL repeat; Region: NHL; pfam01436 1091500008288 NHL repeat; Region: NHL; pfam01436 1091500008289 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1091500008290 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1091500008291 trimer interface [polypeptide binding]; other site 1091500008292 putative metal binding site [ion binding]; other site 1091500008293 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1091500008294 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 1091500008295 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 1091500008296 potential frameshift: common BLAST hit: gi|339633528|ref|YP_004725170.1| oxidoreductase 1091500008297 potential frameshift: common BLAST hit: gi|340628496|ref|YP_004746948.1| PPE family protein 1091500008298 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1091500008299 PPE family; Region: PPE; pfam00823 1091500008300 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1091500008301 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1091500008302 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 1091500008303 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 1091500008304 active site 1091500008305 catalytic residues [active] 1091500008306 metal binding site [ion binding]; metal-binding site 1091500008307 DmpG-like communication domain; Region: DmpG_comm; pfam07836 1091500008308 acetaldehyde dehydrogenase; Validated; Region: PRK08300 1091500008309 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1091500008310 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 1091500008311 2-keto-4-pentenoate hydratase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3971 1091500008312 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843 1091500008313 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1091500008314 enoyl-CoA hydratase; Region: PLN02864 1091500008315 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1091500008316 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 1091500008317 dimer interaction site [polypeptide binding]; other site 1091500008318 substrate-binding tunnel; other site 1091500008319 active site 1091500008320 catalytic site [active] 1091500008321 substrate binding site [chemical binding]; other site 1091500008322 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1091500008323 PPE family; Region: PPE; pfam00823 1091500008324 PE-PPE domain; Region: PE-PPE; pfam08237 1091500008325 lipid-transfer protein; Provisional; Region: PRK07855 1091500008326 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1091500008327 active site 1091500008328 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 1091500008329 putative active site [active] 1091500008330 putative catalytic site [active] 1091500008331 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1091500008332 active site 1091500008333 catalytic site [active] 1091500008334 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1091500008335 DUF35 OB-fold domain; Region: DUF35; pfam01796 1091500008336 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1091500008337 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1091500008338 active site 1091500008339 potential frameshift: common BLAST hit: gi|340628508|ref|YP_004746960.1| putative acyl-CoA dehydrogenase FADE28 1091500008340 potential frameshift: common BLAST hit: gi|340628509|ref|YP_004746961.1| putative cytochrome P450 125 CYP125 1091500008341 acetyl-CoA acetyltransferase; Provisional; Region: PRK07850 1091500008342 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1091500008343 dimer interface [polypeptide binding]; other site 1091500008344 active site 1091500008345 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1091500008346 short chain dehydrogenase; Provisional; Region: PRK07791 1091500008347 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 1091500008348 homodimer interface [polypeptide binding]; other site 1091500008349 NAD binding site [chemical binding]; other site 1091500008350 active site 1091500008351 short chain dehydrogenase; Provisional; Region: PRK07856 1091500008352 classical (c) SDRs; Region: SDR_c; cd05233 1091500008353 NAD(P) binding site [chemical binding]; other site 1091500008354 active site 1091500008355 enoyl-CoA hydratase; Provisional; Region: PRK06495 1091500008356 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1091500008357 substrate binding site [chemical binding]; other site 1091500008358 oxyanion hole (OAH) forming residues; other site 1091500008359 trimer interface [polypeptide binding]; other site 1091500008360 potential frameshift: common BLAST hit: gi|378773332|ref|YP_005173065.1| putative CoA-transferase subunit beta 1091500008361 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1091500008362 Coenzyme A transferase; Region: CoA_trans; cl17247 1091500008363 Nitronate monooxygenase; Region: NMO; pfam03060 1091500008364 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1091500008365 FMN binding site [chemical binding]; other site 1091500008366 substrate binding site [chemical binding]; other site 1091500008367 putative catalytic residue [active] 1091500008368 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1091500008369 Beta-carotene hydroxylase (CrtR), the carotenoid zeaxanthin biosynthetic enzyme catalyzes the addition of hydroxyl groups to the beta-ionone rings of beta-carotene to form zeaxanthin and is found in bacteria and red algae. Carotenoids are important...; Region: CrtR_beta-carotene-hydroxylase; cd03514 1091500008370 putative di-iron ligands [ion binding]; other site 1091500008371 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 1091500008372 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 1091500008373 FAD binding pocket [chemical binding]; other site 1091500008374 FAD binding motif [chemical binding]; other site 1091500008375 phosphate binding motif [ion binding]; other site 1091500008376 beta-alpha-beta structure motif; other site 1091500008377 NAD(p) ribose binding residues [chemical binding]; other site 1091500008378 NAD binding pocket [chemical binding]; other site 1091500008379 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 1091500008380 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1091500008381 catalytic loop [active] 1091500008382 iron binding site [ion binding]; other site 1091500008383 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1091500008384 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1091500008385 putative active site [active] 1091500008386 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 1091500008387 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1091500008388 dimer interface [polypeptide binding]; other site 1091500008389 active site 1091500008390 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1091500008391 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1091500008392 potential frameshift: common BLAST hit: gi|148824764|ref|YP_001289518.1| PPE family protein 1091500008393 short chain dehydrogenase; Provisional; Region: PRK07831 1091500008394 classical (c) SDRs; Region: SDR_c; cd05233 1091500008395 NAD(P) binding site [chemical binding]; other site 1091500008396 active site 1091500008397 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1091500008398 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1091500008399 active site 1091500008400 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 1091500008401 acyl-activating enzyme (AAE) consensus motif; other site 1091500008402 putative AMP binding site [chemical binding]; other site 1091500008403 putative active site [active] 1091500008404 putative CoA binding site [chemical binding]; other site 1091500008405 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1091500008406 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1091500008407 active site 1091500008408 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1091500008409 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1091500008410 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1091500008411 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1091500008412 active site 1091500008413 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1091500008414 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1091500008415 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1091500008416 active site 1091500008417 aspartate aminotransferase; Provisional; Region: PRK05764 1091500008418 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1091500008419 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1091500008420 homodimer interface [polypeptide binding]; other site 1091500008421 catalytic residue [active] 1091500008422 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 1091500008423 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1091500008424 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 1091500008425 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 1091500008426 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 1091500008427 active site 1091500008428 Fe binding site [ion binding]; other site 1091500008429 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1091500008430 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1091500008431 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1091500008432 Naphthocyclinone hydroxylase; Region: NcnH; cd01159 1091500008433 Flavin binding site [chemical binding]; other site 1091500008434 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1091500008435 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 1091500008436 FAD binding pocket [chemical binding]; other site 1091500008437 FAD binding motif [chemical binding]; other site 1091500008438 phosphate binding motif [ion binding]; other site 1091500008439 beta-alpha-beta structure motif; other site 1091500008440 NAD(p) ribose binding residues [chemical binding]; other site 1091500008441 NAD binding pocket [chemical binding]; other site 1091500008442 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 1091500008443 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1091500008444 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1091500008445 catalytic loop [active] 1091500008446 iron binding site [ion binding]; other site 1091500008447 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1091500008448 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1091500008449 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1091500008450 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1091500008451 active site 1091500008452 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1091500008453 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1091500008454 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1091500008455 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1091500008456 DNA binding site [nucleotide binding] 1091500008457 domain linker motif; other site 1091500008458 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 1091500008459 putative dimerization interface [polypeptide binding]; other site 1091500008460 putative ligand binding site [chemical binding]; other site 1091500008461 PknH-like extracellular domain; Region: PknH_C; pfam14032 1091500008462 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1091500008463 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1091500008464 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1091500008465 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1091500008466 transmembrane helices; other site 1091500008467 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1091500008468 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1091500008469 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1091500008470 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1091500008471 potential frameshift: common BLAST hit: gi|340628546|ref|YP_004746998.1| cysteinyl-tRNA synthetase 1 CYSS1 1091500008472 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1091500008473 homotrimer interaction site [polypeptide binding]; other site 1091500008474 zinc binding site [ion binding]; other site 1091500008475 CDP-binding sites; other site 1091500008476 potential frameshift: common BLAST hit: gi|340628548|ref|YP_004747000.1| putative 4-diphosphocytidyl-2C-methyl-D-erythritol synthase ISPD 1091500008477 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 1091500008478 DNA repair protein RadA; Provisional; Region: PRK11823 1091500008479 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1091500008480 Walker A motif/ATP binding site; other site 1091500008481 ATP binding site [chemical binding]; other site 1091500008482 Walker B motif; other site 1091500008483 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1091500008484 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 1091500008485 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1091500008486 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 1091500008487 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 1091500008488 active site clefts [active] 1091500008489 zinc binding site [ion binding]; other site 1091500008490 dimer interface [polypeptide binding]; other site 1091500008491 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1091500008492 endonuclease III; Region: ENDO3c; smart00478 1091500008493 minor groove reading motif; other site 1091500008494 helix-hairpin-helix signature motif; other site 1091500008495 substrate binding pocket [chemical binding]; other site 1091500008496 active site 1091500008497 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1091500008498 PE family; Region: PE; pfam00934 1091500008499 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1091500008500 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1091500008501 catalytic site [active] 1091500008502 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1091500008503 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 1091500008504 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1091500008505 Ami_2 domain; Region: Ami_2; smart00644 1091500008506 amidase catalytic site [active] 1091500008507 Zn binding residues [ion binding]; other site 1091500008508 substrate binding site [chemical binding]; other site 1091500008509 PE family; Region: PE; pfam00934 1091500008510 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1091500008511 Clp amino terminal domain; Region: Clp_N; pfam02861 1091500008512 Clp amino terminal domain; Region: Clp_N; pfam02861 1091500008513 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1091500008514 Walker A motif; other site 1091500008515 ATP binding site [chemical binding]; other site 1091500008516 Walker B motif; other site 1091500008517 arginine finger; other site 1091500008518 UvrB/uvrC motif; Region: UVR; pfam02151 1091500008519 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1091500008520 Walker A motif; other site 1091500008521 ATP binding site [chemical binding]; other site 1091500008522 Walker B motif; other site 1091500008523 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1091500008524 Lsr2; Region: Lsr2; pfam11774 1091500008525 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1091500008526 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1091500008527 dimer interface [polypeptide binding]; other site 1091500008528 putative anticodon binding site; other site 1091500008529 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1091500008530 motif 1; other site 1091500008531 dimer interface [polypeptide binding]; other site 1091500008532 active site 1091500008533 motif 2; other site 1091500008534 motif 3; other site 1091500008535 pantothenate kinase; Reviewed; Region: PRK13318 1091500008536 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1091500008537 tetramerization interface [polypeptide binding]; other site 1091500008538 active site 1091500008539 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1091500008540 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1091500008541 active site 1091500008542 ATP-binding site [chemical binding]; other site 1091500008543 pantoate-binding site; other site 1091500008544 HXXH motif; other site 1091500008545 Rossmann-like domain; Region: Rossmann-like; pfam10727 1091500008546 Uncharacterized conserved protein [Function unknown]; Region: COG5495 1091500008547 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 1091500008548 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 1091500008549 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1091500008550 catalytic center binding site [active] 1091500008551 ATP binding site [chemical binding]; other site 1091500008552 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1091500008553 homooctamer interface [polypeptide binding]; other site 1091500008554 active site 1091500008555 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1091500008556 dihydropteroate synthase; Region: DHPS; TIGR01496 1091500008557 substrate binding pocket [chemical binding]; other site 1091500008558 dimer interface [polypeptide binding]; other site 1091500008559 inhibitor binding site; inhibition site 1091500008560 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1091500008561 homodecamer interface [polypeptide binding]; other site 1091500008562 GTP cyclohydrolase I; Provisional; Region: PLN03044 1091500008563 active site 1091500008564 putative catalytic site residues [active] 1091500008565 zinc binding site [ion binding]; other site 1091500008566 GTP-CH-I/GFRP interaction surface; other site 1091500008567 FtsH Extracellular; Region: FtsH_ext; pfam06480 1091500008568 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1091500008569 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1091500008570 Walker A motif; other site 1091500008571 ATP binding site [chemical binding]; other site 1091500008572 Walker B motif; other site 1091500008573 arginine finger; other site 1091500008574 Peptidase family M41; Region: Peptidase_M41; pfam01434 1091500008575 chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086 1091500008576 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 1091500008577 potential frameshift: common BLAST hit: gi|340628582|ref|YP_004747034.1| putative epoxide hydrolase EPHA 1091500008578 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1091500008579 Proteins of 100 residues with WXG; Region: WXG100; cl02005 1091500008580 Proteins of 100 residues with WXG; Region: WXG100; cl02005 1091500008581 potential frameshift: common BLAST hit: gi|340628586|ref|YP_004747038.1| PPE family protein 1091500008582 PE family; Region: PE; pfam00934 1091500008583 Uncharacterized conserved protein [Function unknown]; Region: COG2968 1091500008584 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 1091500008585 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1091500008586 active site 1091500008587 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1091500008588 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1091500008589 Ligand Binding Site [chemical binding]; other site 1091500008590 Uncharacterized conserved protein [Function unknown]; Region: COG5282 1091500008591 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 1091500008592 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; pfam02113 1091500008593 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 1091500008594 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1091500008595 dimer interface [polypeptide binding]; other site 1091500008596 substrate binding site [chemical binding]; other site 1091500008597 metal binding sites [ion binding]; metal-binding site 1091500008598 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2899 1091500008599 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1091500008600 Ligand binding site; other site 1091500008601 Putative Catalytic site; other site 1091500008602 DXD motif; other site 1091500008603 Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034 1091500008604 Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5285 1091500008605 potential frameshift: common BLAST hit: gi|339633626|ref|YP_004725268.1| UDP-glucose 4-epimerase 1091500008606 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1091500008607 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 1091500008608 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1091500008609 transposase; Provisional; Region: PRK06526 1091500008610 IstB-like ATP binding protein; Region: IstB_IS21; pfam01695 1091500008611 Walker B motif; other site 1091500008612 potential frameshift: common BLAST hit: gi|375297905|ref|YP_005102172.1| transposase 1091500008613 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1091500008614 MULE transposase domain; Region: MULE; pfam10551 1091500008615 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1091500008616 Fic/DOC family; Region: Fic; cl00960 1091500008617 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 1091500008618 VbhA antitoxin and related proteins; Region: VbhA_like; cd11586 1091500008619 DNA polymerase III subunit delta'; Validated; Region: PRK07940 1091500008620 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1091500008621 potential frameshift: common BLAST hit: gi|224992055|ref|YP_002646744.1| transmembrane protein 1091500008622 potential frameshift: common BLAST hit: gi|340628618|ref|YP_004747070.1| DNA topoisomerase I TOPA 1091500008623 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1091500008624 DNA-binding site [nucleotide binding]; DNA binding site 1091500008625 RNA-binding motif; other site 1091500008626 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 1091500008627 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1091500008628 ATP binding site [chemical binding]; other site 1091500008629 putative Mg++ binding site [ion binding]; other site 1091500008630 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1091500008631 nucleotide binding region [chemical binding]; other site 1091500008632 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 1091500008633 PE family; Region: PE; pfam00934 1091500008634 PE family; Region: PE; pfam00934 1091500008635 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 1091500008636 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 1091500008637 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 1091500008638 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 1091500008639 Walker A motif; other site 1091500008640 hexamer interface [polypeptide binding]; other site 1091500008641 ATP binding site [chemical binding]; other site 1091500008642 Walker B motif; other site 1091500008643 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 1091500008644 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1091500008645 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1091500008646 motif II; other site 1091500008647 potential frameshift: common BLAST hit: gi|339633654|ref|YP_004725296.1| dipeptide-transport ATP-binding protein ABC transporter DPPD 1091500008648 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1091500008649 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1091500008650 ABC-ATPase subunit interface; other site 1091500008651 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1091500008652 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1091500008653 dimer interface [polypeptide binding]; other site 1091500008654 conserved gate region; other site 1091500008655 ABC-ATPase subunit interface; other site 1091500008656 potential frameshift: common BLAST hit: gi|253800707|ref|YP_003033708.1| periplasmic dipeptide-binding lipoprotein dppA 1091500008657 acetyl-CoA synthetase; Provisional; Region: PRK00174 1091500008658 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1091500008659 active site 1091500008660 CoA binding site [chemical binding]; other site 1091500008661 acyl-activating enzyme (AAE) consensus motif; other site 1091500008662 AMP binding site [chemical binding]; other site 1091500008663 acetate binding site [chemical binding]; other site 1091500008664 potential frameshift: common BLAST hit: gi|224992078|ref|YP_002646767.1| transmembrane protein 1091500008665 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1091500008666 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1091500008667 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1091500008668 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1091500008669 catalytic residues [active] 1091500008670 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1091500008671 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1091500008672 helix-hairpin-helix signature motif; other site 1091500008673 substrate binding pocket [chemical binding]; other site 1091500008674 active site 1091500008675 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1091500008676 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 1091500008677 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1091500008678 ligand binding site [chemical binding]; other site 1091500008679 flexible hinge region; other site 1091500008680 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1091500008681 putative switch regulator; other site 1091500008682 non-specific DNA interactions [nucleotide binding]; other site 1091500008683 DNA binding site [nucleotide binding] 1091500008684 sequence specific DNA binding site [nucleotide binding]; other site 1091500008685 putative cAMP binding site [chemical binding]; other site 1091500008686 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1091500008687 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 1091500008688 homotrimer interaction site [polypeptide binding]; other site 1091500008689 putative active site [active] 1091500008690 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 1091500008691 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 1091500008692 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1091500008693 P loop; other site 1091500008694 Nucleotide binding site [chemical binding]; other site 1091500008695 DTAP/Switch II; other site 1091500008696 potential frameshift: common BLAST hit: gi|253800724|ref|YP_003033725.1| anion transporter ATPase 1091500008697 Transcription factor WhiB; Region: Whib; pfam02467 1091500008698 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1091500008699 Transglycosylase; Region: Transgly; pfam00912 1091500008700 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1091500008701 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1091500008702 phosphodiesterase YaeI; Provisional; Region: PRK11340 1091500008703 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1091500008704 putative active site [active] 1091500008705 putative metal binding site [ion binding]; other site 1091500008706 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1091500008707 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1091500008708 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1091500008709 catalytic residue [active] 1091500008710 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1091500008711 Cytochrome P450; Region: p450; cl12078 1091500008712 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1091500008713 anti sigma factor interaction site; other site 1091500008714 regulatory phosphorylation site [posttranslational modification]; other site 1091500008715 Uncharacterized conserved protein [Function unknown]; Region: COG1610 1091500008716 potential frameshift: common BLAST hit: gi|340628665|ref|YP_004747117.1| putative methanol dehydrogenase transcriptional regulatory protein 1091500008717 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1091500008718 Protein of unknown function DUF58; Region: DUF58; pfam01882 1091500008719 Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300 1091500008720 Predicted membrane protein/domain [Function unknown]; Region: COG1714 1091500008721 potential frameshift: common BLAST hit: gi|253800740|ref|YP_003033741.1| glycerol kinase 1091500008722 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 1091500008723 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 1091500008724 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1091500008725 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091500008726 S-adenosylmethionine binding site [chemical binding]; other site 1091500008727 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1091500008728 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1091500008729 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1091500008730 catalytic residue [active] 1091500008731 Uncharacterized conserved protein [Function unknown]; Region: COG4301 1091500008732 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 1091500008733 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 1091500008734 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1091500008735 putative active site [active] 1091500008736 putative dimer interface [polypeptide binding]; other site 1091500008737 Gamma-glutamylcysteine synthetase [Coenzyme metabolism]; Region: GshA; COG3572 1091500008738 PknH-like extracellular domain; Region: PknH_C; pfam14032 1091500008739 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 1091500008740 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1091500008741 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1091500008742 aspartate kinase; Reviewed; Region: PRK06635 1091500008743 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1091500008744 putative nucleotide binding site [chemical binding]; other site 1091500008745 putative catalytic residues [active] 1091500008746 putative Mg ion binding site [ion binding]; other site 1091500008747 putative aspartate binding site [chemical binding]; other site 1091500008748 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1091500008749 putative allosteric regulatory site; other site 1091500008750 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1091500008751 putative allosteric regulatory residue; other site 1091500008752 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 1091500008753 active site 1091500008754 catalytic residues [active] 1091500008755 metal binding site [ion binding]; metal-binding site 1091500008756 2-isopropylmalate synthase; Validated; Region: PRK03739 1091500008757 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1091500008758 potential frameshift: common BLAST hit: gi|148824916|ref|YP_001289670.1| DNA polymerase III subunit epsilon 1091500008759 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 1091500008760 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 1091500008761 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1091500008762 catalytic triad [active] 1091500008763 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1091500008764 putative active site [active] 1091500008765 recombination protein RecR; Reviewed; Region: recR; PRK00076 1091500008766 RecR protein; Region: RecR; pfam02132 1091500008767 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1091500008768 putative active site [active] 1091500008769 putative metal-binding site [ion binding]; other site 1091500008770 tetramer interface [polypeptide binding]; other site 1091500008771 hypothetical protein; Validated; Region: PRK00153 1091500008772 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1091500008773 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1091500008774 active site 1091500008775 metal binding site [ion binding]; metal-binding site 1091500008776 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 1091500008777 hydrophobic ligand binding site; other site 1091500008778 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1091500008779 FAD binding domain; Region: FAD_binding_4; pfam01565 1091500008780 potential frameshift: common BLAST hit: gi|253800766|ref|YP_003033767.1| fatty-acid synthase 1091500008781 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14952 1091500008782 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1091500008783 Walker A motif; other site 1091500008784 ATP binding site [chemical binding]; other site 1091500008785 Walker B motif; other site 1091500008786 arginine finger; other site 1091500008787 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1091500008788 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 1091500008789 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1091500008790 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1091500008791 catalytic residue [active] 1091500008792 Cutinase; Region: Cutinase; pfam01083 1091500008793 Cutinase; Region: Cutinase; pfam01083 1091500008794 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1091500008795 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1091500008796 NAD(P) binding site [chemical binding]; other site 1091500008797 active site 1091500008798 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1091500008799 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH8; cd08262 1091500008800 putative NAD(P) binding site [chemical binding]; other site 1091500008801 catalytic Zn binding site [ion binding]; other site 1091500008802 Uncharacterized conserved protein [Function unknown]; Region: COG3349 1091500008803 Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl17487 1091500008804 potential frameshift: common BLAST hit: gi|224992140|ref|YP_002646829.1| two-domain membrane protein 1091500008805 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG1964 1091500008806 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1091500008807 FeS/SAM binding site; other site 1091500008808 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1091500008809 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091500008810 S-adenosylmethionine binding site [chemical binding]; other site 1091500008811 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 1091500008812 nucleotide binding site [chemical binding]; other site 1091500008813 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 1091500008814 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 1091500008815 active site 1091500008816 DNA binding site [nucleotide binding] 1091500008817 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 1091500008818 DNA binding site [nucleotide binding] 1091500008819 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4402 1091500008820 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_5; cd04662 1091500008821 nudix motif; other site 1091500008822 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1091500008823 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1091500008824 Adenosine specific kinase; Region: Adenosine_kin; pfam04008 1091500008825 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1091500008826 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1091500008827 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1091500008828 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1091500008829 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1091500008830 Uncharacterized conserved protein [Function unknown]; Region: COG3610 1091500008831 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1091500008832 PPE family; Region: PPE; pfam00823 1091500008833 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1091500008834 PPE family; Region: PPE; pfam00823 1091500008835 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1091500008836 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1091500008837 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 1091500008838 potential frameshift: common BLAST hit: gi|253800790|ref|YP_003033791.1| cation transporter P-type ATPase ctpJ 1091500008839 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1091500008840 dimerization interface [polypeptide binding]; other site 1091500008841 putative DNA binding site [nucleotide binding]; other site 1091500008842 putative Zn2+ binding site [ion binding]; other site 1091500008843 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3651 1091500008844 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 1091500008845 DNA binding domain, excisionase family; Region: excise; TIGR01764 1091500008846 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1091500008847 nucleoside/Zn binding site; other site 1091500008848 dimer interface [polypeptide binding]; other site 1091500008849 catalytic motif [active] 1091500008850 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 1091500008851 prephenate dehydrogenase; Validated; Region: PRK06545 1091500008852 prephenate dehydrogenase; Validated; Region: PRK08507 1091500008853 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3554 1091500008854 potential frameshift: common BLAST hit: gi|340628727|ref|YP_004747179.1| putative osmoprotectant 1091500008855 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 1091500008856 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1091500008857 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1091500008858 Walker A/P-loop; other site 1091500008859 ATP binding site [chemical binding]; other site 1091500008860 Q-loop/lid; other site 1091500008861 ABC transporter signature motif; other site 1091500008862 Walker B; other site 1091500008863 D-loop; other site 1091500008864 H-loop/switch region; other site 1091500008865 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1091500008866 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 1091500008867 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1091500008868 putative active site [active] 1091500008869 putative substrate binding site [chemical binding]; other site 1091500008870 ATP binding site [chemical binding]; other site 1091500008871 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 1091500008872 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1091500008873 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 1091500008874 potential frameshift: common BLAST hit: gi|253800811|ref|YP_003033812.1| two component system sensor kinase 1091500008875 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1091500008876 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091500008877 active site 1091500008878 phosphorylation site [posttranslational modification] 1091500008879 intermolecular recognition site; other site 1091500008880 dimerization interface [polypeptide binding]; other site 1091500008881 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1091500008882 DNA binding site [nucleotide binding] 1091500008883 Photosystem II reaction centre W protein (PsbW); Region: PsbW; cl06243 1091500008884 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1091500008885 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1091500008886 SnoaL-like domain; Region: SnoaL_2; pfam12680 1091500008887 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 1091500008888 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1091500008889 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1091500008890 homodimer interface [polypeptide binding]; other site 1091500008891 catalytic residue [active] 1091500008892 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1091500008893 TIGR03086 family protein; Region: TIGR03086 1091500008894 potential frameshift: common BLAST hit: gi|340628744|ref|YP_004747196.1| putative enoyl-CoA hydratase ECHA21 1091500008895 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1091500008896 Beta-lactamase; Region: Beta-lactamase; pfam00144 1091500008897 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 1091500008898 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 1091500008899 NAD(P) binding site [chemical binding]; other site 1091500008900 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1091500008901 cysteine desulfurase family protein, VC1184 subfamily; Region: am_tr_V_VC1184; TIGR01976 1091500008902 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1091500008903 catalytic residue [active] 1091500008904 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 1091500008905 potential frameshift: common BLAST hit: gi|339633777|ref|YP_004725419.1| O-antigen/lipopolysaccharide transport ATP-binding protein ABC 1091500008906 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1091500008907 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1091500008908 active site 1091500008909 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1091500008910 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1091500008911 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1091500008912 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 1091500008913 NAD binding site [chemical binding]; other site 1091500008914 substrate binding site [chemical binding]; other site 1091500008915 active site 1091500008916 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1091500008917 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1091500008918 active site 1091500008919 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1091500008920 Peptidase family M23; Region: Peptidase_M23; pfam01551 1091500008921 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1091500008922 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1091500008923 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05892 1091500008924 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1091500008925 Predicted membrane protein [Function unknown]; Region: COG2246 1091500008926 GtrA-like protein; Region: GtrA; pfam04138 1091500008927 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1091500008928 FAD binding domain; Region: FAD_binding_4; pfam01565 1091500008929 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 1091500008930 short chain dehydrogenase; Provisional; Region: PRK07904 1091500008931 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1091500008932 NAD(P) binding site [chemical binding]; other site 1091500008933 active site 1091500008934 Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250 1091500008935 Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249 1091500008936 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 1091500008937 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 1091500008938 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 1091500008939 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 1091500008940 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 1091500008941 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1091500008942 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 1091500008943 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1091500008944 FAD binding site [chemical binding]; other site 1091500008945 substrate binding site [chemical binding]; other site 1091500008946 catalytic residues [active] 1091500008947 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1091500008948 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1091500008949 potential frameshift: common BLAST hit: gi|253800847|ref|YP_003033849.1| propionyl-CoA carboxylase subunit beta 1091500008950 potential frameshift: common BLAST hit: gi|253800848|ref|YP_003033850.1| polyketide synthase 1091500008951 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 1091500008952 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1091500008953 acyl-activating enzyme (AAE) consensus motif; other site 1091500008954 active site 1091500008955 Cutinase; Region: Cutinase; pfam01083 1091500008956 Predicted esterase [General function prediction only]; Region: COG0627 1091500008957 Putative esterase; Region: Esterase; pfam00756 1091500008958 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 1091500008959 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 1091500008960 active site 1091500008961 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1091500008962 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1091500008963 active site 1091500008964 potential frameshift: common BLAST hit: gi|339633804|ref|YP_004725446.1| UDP-galactopyranose mutase 1091500008965 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 1091500008966 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1091500008967 amidase catalytic site [active] 1091500008968 Zn binding residues [ion binding]; other site 1091500008969 substrate binding site [chemical binding]; other site 1091500008970 LGFP repeat; Region: LGFP; pfam08310 1091500008971 PE family; Region: PE; pfam00934 1091500008972 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1091500008973 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1091500008974 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1091500008975 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1091500008976 putative acyl-acceptor binding pocket; other site 1091500008977 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1091500008978 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1091500008979 putative acyl-acceptor binding pocket; other site 1091500008980 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1091500008981 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1091500008982 putative acyl-acceptor binding pocket; other site 1091500008983 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 1091500008984 Phosphotransferase enzyme family; Region: APH; pfam01636 1091500008985 active site 1091500008986 ATP binding site [chemical binding]; other site 1091500008987 antibiotic binding site [chemical binding]; other site 1091500008988 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1091500008989 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1091500008990 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1091500008991 iron-sulfur cluster [ion binding]; other site 1091500008992 [2Fe-2S] cluster binding site [ion binding]; other site 1091500008993 Condensation domain; Region: Condensation; pfam00668 1091500008994 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 1091500008995 PE-PPE domain; Region: PE-PPE; pfam08237 1091500008996 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1091500008997 MMPL family; Region: MMPL; pfam03176 1091500008998 potential frameshift: common BLAST hit: gi|224992237|ref|YP_002646927.1| polyketide synthase associated protein 1091500008999 potential frameshift: common BLAST hit: gi|339633820|ref|YP_004725462.1| polyketide synthase 1091500009000 acyl-CoA synthetase; Validated; Region: PRK05850 1091500009001 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1091500009002 acyl-activating enzyme (AAE) consensus motif; other site 1091500009003 active site 1091500009004 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1091500009005 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1091500009006 Probable transposase; Region: OrfB_IS605; pfam01385 1091500009007 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 1091500009008 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 1091500009009 catalytic residues [active] 1091500009010 catalytic nucleophile [active] 1091500009011 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1091500009012 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1091500009013 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1091500009014 Protein of unknown function (DUF2834); Region: DUF2834; pfam11196 1091500009015 potential frameshift: common BLAST hit: gi|339633828|ref|YP_004725470.1| AraC family transcriptional regulator 1091500009016 seryl-tRNA synthetase; Provisional; Region: PRK05431 1091500009017 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1091500009018 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1091500009019 dimer interface [polypeptide binding]; other site 1091500009020 active site 1091500009021 motif 1; other site 1091500009022 motif 2; other site 1091500009023 motif 3; other site 1091500009024 Septum formation; Region: Septum_form; pfam13845 1091500009025 Septum formation; Region: Septum_form; pfam13845 1091500009026 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 1091500009027 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1091500009028 catalytic core [active] 1091500009029 prephenate dehydratase; Provisional; Region: PRK11898 1091500009030 Prephenate dehydratase; Region: PDT; pfam00800 1091500009031 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1091500009032 putative L-Phe binding site [chemical binding]; other site 1091500009033 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1091500009034 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1091500009035 Ferritin-like domain; Region: Ferritin; pfam00210 1091500009036 ferroxidase diiron center [ion binding]; other site 1091500009037 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582 1091500009038 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 1091500009039 putative active site [active] 1091500009040 catalytic site [active] 1091500009041 putative metal binding site [ion binding]; other site 1091500009042 Domain of unknown function (DUF4328); Region: DUF4328; pfam14219 1091500009043 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1091500009044 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1091500009045 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1091500009046 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1091500009047 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1091500009048 Predicted membrane protein [Function unknown]; Region: COG2119 1091500009049 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 1091500009050 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 1091500009051 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 1091500009052 potential frameshift: common BLAST hit: gi|340628826|ref|YP_004747278.1| monooxygenase ETHA 1091500009053 potential frameshift: common BLAST hit: gi|253800905|ref|YP_003033907.1| monooxygenase ethA 1091500009054 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1091500009055 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1091500009056 hypothetical protein; Provisional; Region: PRK07945 1091500009057 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 1091500009058 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 1091500009059 active site 1091500009060 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 1091500009061 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1091500009062 potential frameshift: common BLAST hit: gi|253800910|ref|YP_003033912.1| ferredoxin-dependent glutamate synthase [NADPH] large subunit gltB 1091500009063 potential frameshift: common BLAST hit: gi|253800910|ref|YP_003033912.1| ferredoxin-dependent glutamate synthase [NADPH] large subunit gltB 1091500009064 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1091500009065 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 1091500009066 EspG family; Region: ESX-1_EspG; pfam14011 1091500009067 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 1091500009068 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1091500009069 Walker A motif; other site 1091500009070 ATP binding site [chemical binding]; other site 1091500009071 Walker B motif; other site 1091500009072 arginine finger; other site 1091500009073 Protein of unknown function (DUF690); Region: DUF690; cl04939 1091500009074 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1091500009075 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1091500009076 PE family; Region: PE; pfam00934 1091500009077 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1091500009078 PPE family; Region: PPE; pfam00823 1091500009079 Proteins of 100 residues with WXG; Region: WXG100; cl02005 1091500009080 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1091500009081 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1091500009082 potential frameshift: common BLAST hit: gi|148663744|ref|YP_001285267.1| transmembrane protein 1091500009083 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 1091500009084 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1091500009085 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 1091500009086 active site 1091500009087 catalytic residues [active] 1091500009088 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 1091500009089 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1091500009090 Walker A motif; other site 1091500009091 ATP binding site [chemical binding]; other site 1091500009092 Walker B motif; other site 1091500009093 arginine finger; other site 1091500009094 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 1091500009095 potential frameshift: common BLAST hit: gi|340628858|ref|YP_004747310.1| putative alanine and proline rich membrane-anchored mycosin MYCP2 1091500009096 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 1091500009097 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1091500009098 Proteins of 100 residues with WXG; Region: WXG100; cl02005 1091500009099 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1091500009100 potential frameshift: common BLAST hit: gi|224992298|ref|YP_002646988.1| PPE family protein 1091500009101 potential frameshift: common BLAST hit: gi|15843525|ref|NP_338562.1| FtsK/SpoIIIE family protein 1091500009102 Protein of unknown function (DUF690); Region: DUF690; pfam05108 1091500009103 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1091500009104 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1091500009105 catalytic residue [active] 1091500009106 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1091500009107 potential frameshift: common BLAST hit: gi|340628877|ref|YP_004747329.1| putative poly(A) polymerase PcnA 1091500009108 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1091500009109 active site 1091500009110 Ap6A binding site [chemical binding]; other site 1091500009111 nudix motif; other site 1091500009112 metal binding site [ion binding]; metal-binding site 1091500009113 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 1091500009114 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1091500009115 RNA polymerase sigma factor SigM; Reviewed; Region: PRK09643 1091500009116 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1091500009117 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1091500009118 DNA binding residues [nucleotide binding] 1091500009119 potential frameshift: common BLAST hit: gi|340628883|ref|YP_004747335.1| putative thioredoxin reductase TRXB2 (TRXR) (TR) 1091500009120 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1091500009121 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1091500009122 catalytic residues [active] 1091500009123 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1091500009124 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1091500009125 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1091500009126 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1091500009127 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1091500009128 active site 1091500009129 metal binding site [ion binding]; metal-binding site 1091500009130 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1091500009131 ParB-like nuclease domain; Region: ParB; smart00470 1091500009132 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1091500009133 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1091500009134 P-loop; other site 1091500009135 Magnesium ion binding site [ion binding]; other site 1091500009136 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1091500009137 Magnesium ion binding site [ion binding]; other site 1091500009138 potential frameshift: common BLAST hit: gi|340628889|ref|YP_004747341.1| putative glucose-inhibited division protein B GID 1091500009139 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 1091500009140 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1091500009141 G-X-X-G motif; other site 1091500009142 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 1091500009143 RxxxH motif; other site 1091500009144 putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449 1091500009145 Uncharacterized conserved protein [Function unknown]; Region: COG0759 1091500009146 ribonuclease P; Reviewed; Region: rnpA; PRK00588 1091500009147 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399