-- dump date   	20140619_155157
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
1091501000001	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1091501000002	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1091501000003	Walker A motif; other site
1091501000004	ATP binding site [chemical binding]; other site
1091501000005	Walker B motif; other site
1091501000006	arginine finger; other site
1091501000007	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
1091501000008	DnaA box-binding interface [nucleotide binding]; other site
1091501000009	potential frameshift: common BLAST hit: gi|339630085|ref|YP_004721727.1| DNA polymerase III subunit beta
1091501000010	recF protein; Region: recf; TIGR00611
1091501000011	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1091501000012	Q-loop/lid; other site
1091501000013	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1091501000014	Walker B; other site
1091501000015	D-loop; other site
1091501000016	H-loop/switch region; other site
1091501000017	hypothetical protein; Provisional; Region: PRK03195
1091501000018	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
1091501000019	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1091501000020	Mg2+ binding site [ion binding]; other site
1091501000021	G-X-G motif; other site
1091501000022	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
1091501000023	anchoring element; other site
1091501000024	dimer interface [polypeptide binding]; other site
1091501000025	ATP binding site [chemical binding]; other site
1091501000026	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
1091501000027	active site
1091501000028	putative metal-binding site [ion binding]; other site
1091501000029	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
1091501000030	potential frameshift: common BLAST hit: gi|340625039|ref|YP_004743491.1| DNA gyrase subunit A GYRA
1091501000031	Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089
1091501000032	Protein of unknown function (DUF3800); Region: DUF3800; pfam12686
1091501000033	Protein of unknown function (DUF2562); Region: DUF2562; pfam10814
1091501000034	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
1091501000035	active site
1091501000036	Protein of unknown function (DUF2581); Region: DUF2581; pfam10756
1091501000037	putative septation inhibitor protein; Reviewed; Region: PRK00159
1091501000038	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879
1091501000039	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
1091501000040	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
1091501000041	Glutamine amidotransferase class-I; Region: GATase; pfam00117
1091501000042	glutamine binding [chemical binding]; other site
1091501000043	catalytic triad [active]
1091501000044	potential frameshift: common BLAST hit: gi|340625047|ref|YP_004743499.1| transmembrane serine/threonine-protein kinase B
1091501000045	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1091501000046	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1091501000047	active site
1091501000048	ATP binding site [chemical binding]; other site
1091501000049	substrate binding site [chemical binding]; other site
1091501000050	activation loop (A-loop); other site
1091501000051	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
1091501000052	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1091501000053	potential frameshift: common BLAST hit: gi|339630100|ref|YP_004721742.1| cell division protein RodA
1091501000054	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
1091501000055	active site
1091501000056	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
1091501000057	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1091501000058	phosphopeptide binding site; other site
1091501000059	Protein of unknown function (DUF2662); Region: DUF3662; pfam12401
1091501000060	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1091501000061	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
1091501000062	phosphopeptide binding site; other site
1091501000063	potential frameshift: common BLAST hit: gi|148659780|ref|YP_001281303.1| 2-nitropropane dioxygenase
1091501000064	Transcription factor WhiB; Region: Whib; pfam02467
1091501000065	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1091501000066	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1091501000067	non-specific DNA binding site [nucleotide binding]; other site
1091501000068	salt bridge; other site
1091501000069	sequence-specific DNA binding site [nucleotide binding]; other site
1091501000070	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1091501000071	NlpC/P60 family; Region: NLPC_P60; pfam00877
1091501000072	Domain of unknown function (DUF4226); Region: DUF4226; pfam10774
1091501000073	Domain of unknown function (DUF4226); Region: DUF4226; pfam10774
1091501000074	Protein of unknown function (DUF2580); Region: DUF2580; pfam10824
1091501000075	Protein of unknown function (DUF2694); Region: DUF2694; pfam10904
1091501000076	Protein of unknown function (DUF2710); Region: DUF2710; pfam10921
1091501000077	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
1091501000078	7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156
1091501000079	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
1091501000080	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1091501000081	catalytic residue [active]
1091501000082	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
1091501000083	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
1091501000084	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
1091501000085	acyl-activating enzyme (AAE) consensus motif; other site
1091501000086	active site
1091501000087	TIGR03084 family protein; Region: TIGR03084
1091501000088	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
1091501000089	Wyosine base formation; Region: Wyosine_form; pfam08608
1091501000090	H+ Antiporter protein; Region: 2A0121; TIGR00900
1091501000091	Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738
1091501000092	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
1091501000093	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1091501000094	active site
1091501000095	HIGH motif; other site
1091501000096	nucleotide binding site [chemical binding]; other site
1091501000097	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1091501000098	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1091501000099	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1091501000100	active site
1091501000101	KMSKS motif; other site
1091501000102	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
1091501000103	tRNA binding surface [nucleotide binding]; other site
1091501000104	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1091501000105	MarR family; Region: MarR; pfam01047
1091501000106	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1091501000107	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1091501000108	DNA-binding site [nucleotide binding]; DNA binding site
1091501000109	probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856
1091501000110	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1091501000111	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1091501000112	Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554
1091501000113	Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260
1091501000114	Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554
1091501000115	Predicted transcriptional regulators [Transcription]; Region: COG1695
1091501000116	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
1091501000117	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
1091501000118	potential frameshift: common BLAST hit: gi|253796965|ref|YP_003029966.1| bifunctional penicillin-binding protein ponA1
1091501000119	potential frameshift: common BLAST hit: gi|224988434|ref|YP_002643101.1| transmembrane protein
1091501000120	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
1091501000121	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
1091501000122	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
1091501000123	dimer interface [polypeptide binding]; other site
1091501000124	ssDNA binding site [nucleotide binding]; other site
1091501000125	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1091501000126	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
1091501000127	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
1091501000128	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
1091501000129	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
1091501000130	potential frameshift: common BLAST hit: gi|253796973|ref|YP_003029974.1| replicative DNA helicase
1091501000131	potential frameshift: common BLAST hit: gi|253796973|ref|YP_003029974.1| replicative DNA helicase
1091501000132	Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901
1091501000133	ADP-ribose binding site [chemical binding]; other site
1091501000134	Predicted phosphatase homologous to the C-terminal domain of histone macroH2A1 [General function prediction only]; Region: COG2110
1091501000135	Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341
1091501000136	potential frameshift: common BLAST hit: gi|339630146|ref|YP_004721788.1| oxidoreductase
1091501000137	PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873
1091501000138	homotetrameric interface [polypeptide binding]; other site
1091501000139	putative active site [active]
1091501000140	metal binding site [ion binding]; metal-binding site
1091501000141	Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838
1091501000142	Monomeric isocitrate dehydrogenase; Region: IDH; pfam03971
1091501000143	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1091501000144	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1091501000145	short chain dehydrogenase; Provisional; Region: PRK06197
1091501000146	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
1091501000147	putative NAD(P) binding site [chemical binding]; other site
1091501000148	active site
1091501000149	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
1091501000150	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
1091501000151	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
1091501000152	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
1091501000153	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
1091501000154	dimer interface [polypeptide binding]; other site
1091501000155	active site
1091501000156	glycine-pyridoxal phosphate binding site [chemical binding]; other site
1091501000157	folate binding site [chemical binding]; other site
1091501000158	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
1091501000159	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
1091501000160	putative NTP binding site [chemical binding]; other site
1091501000161	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1091501000162	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1091501000163	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1091501000164	Walker A/P-loop; other site
1091501000165	ATP binding site [chemical binding]; other site
1091501000166	Q-loop/lid; other site
1091501000167	ABC transporter signature motif; other site
1091501000168	Walker B; other site
1091501000169	D-loop; other site
1091501000170	H-loop/switch region; other site
1091501000171	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1091501000172	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1091501000173	ligand binding site [chemical binding]; other site
1091501000174	flexible hinge region; other site
1091501000175	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
1091501000176	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1091501000177	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1091501000178	homodimer interface [polypeptide binding]; other site
1091501000179	catalytic residue [active]
1091501000180	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1091501000181	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1091501000182	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1091501000183	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900
1091501000184	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1091501000185	dimerization interface [polypeptide binding]; other site
1091501000186	putative DNA binding site [nucleotide binding]; other site
1091501000187	putative Zn2+ binding site [ion binding]; other site
1091501000188	Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260
1091501000189	hydrogenase 4 subunit B; Validated; Region: PRK06521
1091501000190	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1091501000191	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
1091501000192	NADH dehydrogenase; Region: NADHdh; cl00469
1091501000193	Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; COG4237
1091501000194	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1091501000195	Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262
1091501000196	Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261
1091501000197	NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338
1091501000198	Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259
1091501000199	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825
1091501000200	putative hydrophobic ligand binding site [chemical binding]; other site
1091501000201	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1091501000202	S-adenosylmethionine binding site [chemical binding]; other site
1091501000203	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
1091501000204	potential frameshift: common BLAST hit: gi|339630176|ref|YP_004721818.1| ATPase P
1091501000205	potential frameshift: common BLAST hit: gi|148821284|ref|YP_001286038.1| cation transporter ATPase A ctpA
1091501000206	Predicted integral membrane protein [Function unknown]; Region: COG5660
1091501000207	Putative zinc-finger; Region: zf-HC2; pfam13490
1091501000208	Domain of unknown function (DUF222); Region: DUF222; pfam02720
1091501000209	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1091501000210	active site
1091501000211	Domain of unknown function (DUF222); Region: DUF222; pfam02720
1091501000212	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1091501000213	PPE family; Region: PPE; pfam00823
1091501000214	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
1091501000215	Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668
1091501000216	FcoT-like thioesterase domain; Region: FcoT; pfam10862
1091501000217	acyl-CoA synthetase; Validated; Region: PRK05857
1091501000218	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1091501000219	Adenylate forming domain, Class I; Region: AFD_class_I; cd04433
1091501000220	acyl-activating enzyme (AAE) consensus motif; other site
1091501000221	acyl-activating enzyme (AAE) consensus motif; other site
1091501000222	AMP binding site [chemical binding]; other site
1091501000223	active site
1091501000224	CoA binding site [chemical binding]; other site
1091501000225	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1091501000226	potential frameshift: common BLAST hit: gi|224988487|ref|YP_002643174.1| peptide synthetase
1091501000227	potential frameshift: common BLAST hit: gi|31791279|ref|NP_853772.1| peptide synthetase
1091501000228	potential frameshift: common BLAST hit: gi|224988488|ref|YP_002643175.1| integral membrane protein
1091501000229	potential frameshift: common BLAST hit: gi|224988489|ref|YP_002643176.1| cation-transporter P-type ATPase B
1091501000230	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1091501000231	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1091501000232	ligand binding site [chemical binding]; other site
1091501000233	flexible hinge region; other site
1091501000234	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
1091501000235	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
1091501000236	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
1091501000237	potential frameshift: common BLAST hit: gi|148659870|ref|YP_001281393.1| cation-transporter ATPase I CtpI
1091501000238	PE family; Region: PE; pfam00934
1091501000239	Rhomboid family; Region: Rhomboid; pfam01694
1091501000240	potential frameshift: common BLAST hit: gi|340625146|ref|YP_004743598.1| putative transmembrane acyltransferase
1091501000241	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1091501000242	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
1091501000243	NADP-binding site; other site
1091501000244	homotetramer interface [polypeptide binding]; other site
1091501000245	substrate binding site [chemical binding]; other site
1091501000246	homodimer interface [polypeptide binding]; other site
1091501000247	active site
1091501000248	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
1091501000249	dimer interface [polypeptide binding]; other site
1091501000250	active site
1091501000251	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
1091501000252	Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605
1091501000253	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
1091501000254	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431
1091501000255	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1091501000256	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1091501000257	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1091501000258	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1091501000259	dimerization interface [polypeptide binding]; other site
1091501000260	putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259
1091501000261	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1091501000262	PYR/PP interface [polypeptide binding]; other site
1091501000263	dimer interface [polypeptide binding]; other site
1091501000264	TPP binding site [chemical binding]; other site
1091501000265	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1091501000266	Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004
1091501000267	TPP-binding site; other site
1091501000268	dimer interface [polypeptide binding]; other site
1091501000269	potential frameshift: common BLAST hit: gi|224988505|ref|YP_002643192.1| acyl-CoA synthetase
1091501000270	potential frameshift: common BLAST hit: gi|340625155|ref|YP_004743607.1| putative elongation factor G FUSA2 (EF-G)
1091501000271	PPOX class probable F420-dependent enzyme, Rv0121 family; Region: Rv0121_F420; TIGR03668
1091501000272	PE family; Region: PE; pfam00934
1091501000273	potential frameshift: common BLAST hit: gi|339630207|ref|YP_004721849.1| serine protease
1091501000274	potential frameshift: common BLAST hit: gi|340625161|ref|YP_004743613.1| trehalose synthase TRES
1091501000275	trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457
1091501000276	Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281
1091501000277	Predicted membrane protein [Function unknown]; Region: COG3619
1091501000278	Predicted esterase [General function prediction only]; Region: COG0627
1091501000279	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
1091501000280	putative active site [active]
1091501000281	putative catalytic site [active]
1091501000282	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1091501000283	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1091501000284	active site
1091501000285	F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557
1091501000286	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
1091501000287	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
1091501000288	Coenzyme A binding pocket [chemical binding]; other site
1091501000289	potential frameshift: common BLAST hit: gi|339630216|ref|YP_004721858.1| epoxide hydrolase
1091501000290	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1091501000291	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1091501000292	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1091501000293	Cytochrome P450; Region: p450; cl12078
1091501000294	methionine sulfoxide reductase A; Provisional; Region: PRK14054
1091501000295	SnoaL-like domain; Region: SnoaL_2; pfam12680
1091501000296	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
1091501000297	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1091501000298	NAD(P) binding site [chemical binding]; other site
1091501000299	active site
1091501000300	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343
1091501000301	Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631
1091501000302	3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122
1091501000303	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1091501000304	helix-hairpin-helix signature motif; other site
1091501000305	active site
1091501000306	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
1091501000307	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
1091501000308	Cl- selectivity filter; other site
1091501000309	Cl- binding residues [ion binding]; other site
1091501000310	pore gating glutamate residue; other site
1091501000311	dimer interface [polypeptide binding]; other site
1091501000312	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1091501000313	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1091501000314	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
1091501000315	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
1091501000316	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
1091501000317	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
1091501000318	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
1091501000319	ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087
1091501000320	NAD(P) binding site [chemical binding]; other site
1091501000321	catalytic residues [active]
1091501000322	short chain dehydrogenase; Provisional; Region: PRK07791
1091501000323	(3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353
1091501000324	NAD binding site [chemical binding]; other site
1091501000325	homodimer interface [polypeptide binding]; other site
1091501000326	active site
1091501000327	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1091501000328	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
1091501000329	NAD(P) binding site [chemical binding]; other site
1091501000330	PE family; Region: PE; pfam00934
1091501000331	PE-PPE domain; Region: PE-PPE; pfam08237
1091501000332	PE family; Region: PE; pfam00934
1091501000333	potential frameshift: common BLAST hit: gi|339630235|ref|YP_004721877.1| phosphotyrosine protein phosphatase
1091501000334	potential frameshift: common BLAST hit: gi|339630236|ref|YP_004721878.1| acyl-CoA dehydrogenase
1091501000335	Protein of unknown function (DUF1348); Region: DUF1348; pfam07080
1091501000336	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
1091501000337	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
1091501000338	ligand binding site [chemical binding]; other site
1091501000339	homodimer interface [polypeptide binding]; other site
1091501000340	NAD(P) binding site [chemical binding]; other site
1091501000341	trimer interface B [polypeptide binding]; other site
1091501000342	trimer interface A [polypeptide binding]; other site
1091501000343	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
1091501000344	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
1091501000345	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
1091501000346	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
1091501000347	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1091501000348	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1091501000349	QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360
1091501000350	PE-PPE domain; Region: PE-PPE; pfam08237
1091501000351	PE family; Region: PE; pfam00934
1091501000352	PE-PPE domain; Region: PE-PPE; pfam08237
1091501000353	PE family; Region: PE; pfam00934
1091501000354	PE-PPE domain; Region: PE-PPE; pfam08237
1091501000355	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1091501000356	FAD binding domain; Region: FAD_binding_4; pfam01565
1091501000357	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
1091501000358	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1091501000359	NAD(P) binding site [chemical binding]; other site
1091501000360	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1091501000361	active site
1091501000362	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819
1091501000363	putative hydrophobic ligand binding site [chemical binding]; other site
1091501000364	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1091501000365	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1091501000366	DNA-binding site [nucleotide binding]; DNA binding site
1091501000367	FCD domain; Region: FCD; pfam07729
1091501000368	potential frameshift: common BLAST hit: gi|224988551|ref|YP_002643238.1| long-chain-fatty-acid--CoA ligase
1091501000369	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
1091501000370	Permease; Region: Permease; pfam02405
1091501000371	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
1091501000372	mce related protein; Region: MCE; pfam02470
1091501000373	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
1091501000374	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
1091501000375	mce related protein; Region: MCE; pfam02470
1091501000376	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
1091501000377	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
1091501000378	mce related protein; Region: MCE; pfam02470
1091501000379	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
1091501000380	mce related protein; Region: MCE; pfam02470
1091501000381	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
1091501000382	mce related protein; Region: MCE; pfam02470
1091501000383	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
1091501000384	mce related protein; Region: MCE; pfam02470
1091501000385	RDD family; Region: RDD; pfam06271
1091501000386	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
1091501000387	potential frameshift: common BLAST hit: gi|224988565|ref|YP_002643252.1| transmembrane protein
1091501000388	Pirin-related protein [General function prediction only]; Region: COG1741
1091501000389	Pirin; Region: Pirin; pfam02678
1091501000390	RNA polymerase factor sigma-70; Validated; Region: PRK08241
1091501000391	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1091501000392	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1091501000393	DNA binding residues [nucleotide binding]
1091501000394	SnoaL-like domain; Region: SnoaL_2; pfam12680
1091501000395	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
1091501000396	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1091501000397	Protein of unknown function (DUF2786); Region: DUF2786; pfam10979
1091501000398	putative metallohydrolase, TIGR04338 family; Region: HEXXH_Rv0185
1091501000399	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
1091501000400	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
1091501000401	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
1091501000402	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
1091501000403	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
1091501000404	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1091501000405	S-adenosylmethionine binding site [chemical binding]; other site
1091501000406	SPW repeat; Region: SPW; pfam03779
1091501000407	SPW repeat; Region: SPW; pfam03779
1091501000408	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
1091501000409	6-phosphogluconate dehydratase; Region: edd; TIGR01196
1091501000410	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
1091501000411	putative homodimer interface [polypeptide binding]; other site
1091501000412	putative homotetramer interface [polypeptide binding]; other site
1091501000413	putative allosteric switch controlling residues; other site
1091501000414	putative metal binding site [ion binding]; other site
1091501000415	putative homodimer-homodimer interface [polypeptide binding]; other site
1091501000416	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1091501000417	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1091501000418	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
1091501000419	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431
1091501000420	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1091501000421	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1091501000422	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1091501000423	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1091501000424	Walker A/P-loop; other site
1091501000425	ATP binding site [chemical binding]; other site
1091501000426	Q-loop/lid; other site
1091501000427	ABC transporter signature motif; other site
1091501000428	Walker B; other site
1091501000429	D-loop; other site
1091501000430	H-loop/switch region; other site
1091501000431	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1091501000432	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1091501000433	Walker A/P-loop; other site
1091501000434	ATP binding site [chemical binding]; other site
1091501000435	Q-loop/lid; other site
1091501000436	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1091501000437	ABC transporter signature motif; other site
1091501000438	Walker B; other site
1091501000439	D-loop; other site
1091501000440	H-loop/switch region; other site
1091501000441	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1091501000442	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1091501000443	dimerization interface [polypeptide binding]; other site
1091501000444	DNA binding residues [nucleotide binding]
1091501000445	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1091501000446	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1091501000447	potential frameshift: common BLAST hit: gi|224988582|ref|YP_002643269.1| oxidoreductase
1091501000448	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
1091501000449	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
1091501000450	active site
1091501000451	Zn binding site [ion binding]; other site
1091501000452	potential frameshift: common BLAST hit: gi|253797124|ref|YP_003030125.1| transmembrane transporter mmpL11
1091501000453	potential frameshift: common BLAST hit: gi|253797124|ref|YP_003030125.1| transmembrane transporter mmpL11
1091501000454	Predicted integral membrane protein [Function unknown]; Region: COG0392
1091501000455	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1091501000456	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1091501000457	MMPL family; Region: MMPL; pfam03176
1091501000458	MMPL family; Region: MMPL; pfam03176
1091501000459	LabA_like proteins; Region: LabA_like; cd06167
1091501000460	putative metal binding site [ion binding]; other site
1091501000461	Putative methyltransferase; Region: Methyltransf_4; pfam02390
1091501000462	potential frameshift: common BLAST hit: gi|339630290|ref|YP_004721932.1| phosphoenolpyruvate carboxykinase
1091501000463	nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526
1091501000464	Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167
1091501000465	active site
1091501000466	(T/H)XGH motif; other site
1091501000467	Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172
1091501000468	potential frameshift: common BLAST hit: gi|253797135|ref|YP_003030136.1| methyltransferase/methylase
1091501000469	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1091501000470	acyl-activating enzyme (AAE) consensus motif; other site
1091501000471	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1091501000472	acyl-activating enzyme (AAE) consensus motif; other site
1091501000473	active site
1091501000474	AMP binding site [chemical binding]; other site
1091501000475	CoA binding site [chemical binding]; other site
1091501000476	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1091501000477	CoA binding site [chemical binding]; other site
1091501000478	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1091501000479	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1091501000480	active site
1091501000481	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
1091501000482	active site 2 [active]
1091501000483	active site 1 [active]
1091501000484	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1091501000485	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1091501000486	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
1091501000487	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cd00321
1091501000488	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
1091501000489	Moco binding site; other site
1091501000490	metal coordination site [ion binding]; other site
1091501000491	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1091501000492	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1091501000493	enoyl-CoA hydratase; Provisional; Region: PRK08252
1091501000494	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1091501000495	substrate binding site [chemical binding]; other site
1091501000496	oxyanion hole (OAH) forming residues; other site
1091501000497	trimer interface [polypeptide binding]; other site
1091501000498	potential frameshift: common BLAST hit: gi|340625260|ref|YP_004743712.1| putative aldehyde dehydrogenase
1091501000499	potential frameshift: common BLAST hit: gi|339630300|ref|YP_004721942.1| methyltransferase
1091501000500	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1091501000501	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1091501000502	Protein of unknown function (DUF3068); Region: DUF3068; pfam11271
1091501000503	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
1091501000504	PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882
1091501000505	putative active site [active]
1091501000506	Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530
1091501000507	active site
1091501000508	substrate binding pocket [chemical binding]; other site
1091501000509	homodimer interaction site [polypeptide binding]; other site
1091501000510	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1091501000511	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
1091501000512	active site
1091501000513	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1091501000514	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1091501000515	Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain; Region: RNRR2_Rv0233_like; cd07911
1091501000516	active site
1091501000517	diiron metal binding site [ion binding]; other site
1091501000518	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
1091501000519	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
1091501000520	NAD(P) binding site [chemical binding]; other site
1091501000521	catalytic residues [active]
1091501000522	potential frameshift: common BLAST hit: gi|224988620|ref|YP_002643307.1| transmembrane protein
1091501000523	potential frameshift: common BLAST hit: gi|148660000|ref|YP_001281523.1| transmembrane protein
1091501000524	potential frameshift: common BLAST hit: gi|148660000|ref|YP_001281523.1| transmembrane protein
1091501000525	Protein of unknown function (DUF2613); Region: DUF2613; pfam11021
1091501000526	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
1091501000527	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
1091501000528	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1091501000529	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1091501000530	Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028
1091501000531	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
1091501000532	MaoC like domain; Region: MaoC_dehydratas; pfam01575
1091501000533	active site 2 [active]
1091501000534	active site 1 [active]
1091501000535	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261
1091501000536	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1091501000537	NAD(P) binding site [chemical binding]; other site
1091501000538	active site
1091501000539	acetyl-CoA acetyltransferase; Provisional; Region: PRK09268
1091501000540	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1091501000541	dimer interface [polypeptide binding]; other site
1091501000542	active site
1091501000543	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
1091501000544	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
1091501000545	Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153
1091501000546	FAD binding site [chemical binding]; other site
1091501000547	substrate binding site [chemical binding]; other site
1091501000548	catalytic residues [active]
1091501000549	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
1091501000550	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
1091501000551	fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386
1091501000552	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1091501000553	catalytic loop [active]
1091501000554	iron binding site [ion binding]; other site
1091501000555	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803
1091501000556	L-aspartate oxidase; Provisional; Region: PRK06175
1091501000557	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
1091501000558	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
1091501000559	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
1091501000560	putative dimer interface [polypeptide binding]; other site
1091501000561	potential frameshift: common BLAST hit: gi|339630329|ref|YP_004721971.1| nitrite reductase [NAD(P)H] large subunit
1091501000562	Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529
1091501000563	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
1091501000564	homotrimer interface [polypeptide binding]; other site
1091501000565	Walker A motif; other site
1091501000566	GTP binding site [chemical binding]; other site
1091501000567	Walker B motif; other site
1091501000568	potential frameshift: common BLAST hit: gi|339630332|ref|YP_004721974.1| cobyric acid synthase
1091501000569	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1091501000570	PPE family; Region: PPE; pfam00823
1091501000571	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
1091501000572	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
1091501000573	putative active site [active]
1091501000574	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414
1091501000575	putative active site [active]
1091501000576	potential frameshift: common BLAST hit: gi|339630336|ref|YP_004721978.1| transcriptional regulator
1091501000577	nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886
1091501000578	potential frameshift: common BLAST hit: gi|340625299|ref|YP_004743751.1| aminoglycoside 2'-N-acetyltransferase
1091501000579	Allophanate hydrolase subunit 2; Region: AHS2; cl00865
1091501000580	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
1091501000581	Allophanate hydrolase subunit 1; Region: AHS1; smart00796
1091501000582	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1091501000583	intersubunit interface [polypeptide binding]; other site
1091501000584	5-oxoprolinase; Region: PLN02666
1091501000585	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
1091501000586	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
1091501000587	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
1091501000588	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
1091501000589	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161
1091501000590	AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287
1091501000591	nucleotide binding site [chemical binding]; other site
1091501000592	acyl-CoA synthetase; Validated; Region: PRK07788
1091501000593	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1091501000594	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1091501000595	active site
1091501000596	CoA binding site [chemical binding]; other site
1091501000597	AMP binding site [chemical binding]; other site
1091501000598	potential frameshift: common BLAST hit: gi|224988657|ref|YP_002643344.1| acyl-CoA dehydrogenase
1091501000599	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1091501000600	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1091501000601	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1091501000602	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662
1091501000603	Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028
1091501000604	putative active site [active]
1091501000605	PE family; Region: PE; pfam00934
1091501000606	potential frameshift: common BLAST hit: gi|253797207|ref|YP_003030208.1| PPE family protein
1091501000607	type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922
1091501000608	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1091501000609	Walker A motif; other site
1091501000610	ATP binding site [chemical binding]; other site
1091501000611	Walker B motif; other site
1091501000612	arginine finger; other site
1091501000613	Protein of unknown function (DUF690); Region: DUF690; cl04939
1091501000614	Protein of unknown function (DUF690); Region: DUF690; cl04939
1091501000615	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1091501000616	PPE family; Region: PPE; pfam00823
1091501000617	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842
1091501000618	EspG family; Region: ESX-1_EspG; pfam14011
1091501000619	potential frameshift: common BLAST hit: gi|148821488|ref|YP_001286242.1| transmembrane protein
1091501000620	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
1091501000621	type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921
1091501000622	active site
1091501000623	catalytic residues [active]
1091501000624	type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923
1091501000625	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1091501000626	Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752
1091501000627	Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106
1091501000628	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1091501000629	S-adenosylmethionine binding site [chemical binding]; other site
1091501000630	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4424
1091501000631	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
1091501000632	Sulfatase; Region: Sulfatase; cl17466
1091501000633	potential frameshift: common BLAST hit: gi|148821495|ref|YP_001286249.1| PE-PGRS family protein
1091501000634	hypothetical protein; Region: PHA01748
1091501000635	PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882
1091501000636	putative active site [active]
1091501000637	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1091501000638	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1091501000639	potential frameshift: common BLAST hit: gi|339630378|ref|YP_004722020.1| dehydrogenase/reductase
1091501000640	potential frameshift: common BLAST hit: gi|15839689|ref|NP_334726.1| PPE family protein
1091501000641	potential frameshift: common BLAST hit: gi|340625336|ref|YP_004743788.1| ppe family protein
1091501000642	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
1091501000643	FMN binding site [chemical binding]; other site
1091501000644	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786
1091501000645	SnoaL-like domain; Region: SnoaL_4; pfam13577
1091501000646	SnoaL-like domain; Region: SnoaL_3; pfam13474
1091501000647	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
1091501000648	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1091501000649	nucleotide binding site [chemical binding]; other site
1091501000650	Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones]; Region: HtpG; COG0326
1091501000651	Protein of unknown function (DUF3060); Region: DUF3060; pfam11259
1091501000652	Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273
1091501000653	Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023
1091501000654	active site
1091501000655	catalytic residues [active]
1091501000656	Muconolactone delta-isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CatC1; COG4829
1091501000657	Muconolactone delta-isomerase; Region: MIase; cl01992
1091501000658	Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561
1091501000659	Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009
1091501000660	putative active site [active]
1091501000661	catalytic site [active]
1091501000662	putative metal binding site [ion binding]; other site
1091501000663	potential protein location (hypothetical protein MRGA423_02025 [Mycobacterium tuberculosis RGTB423]) that overlaps RNA (tRNA-G)
1091501000664	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501
1091501000665	putative substrate binding pocket [chemical binding]; other site
1091501000666	AC domain interface; other site
1091501000667	catalytic triad [active]
1091501000668	AB domain interface; other site
1091501000669	interchain disulfide; other site
1091501000670	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
1091501000671	trimer interface [polypeptide binding]; other site
1091501000672	active site
1091501000673	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
1091501000674	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1091501000675	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
1091501000676	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
1091501000677	Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120
1091501000678	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1091501000679	dimerization interface [polypeptide binding]; other site
1091501000680	putative DNA binding site [nucleotide binding]; other site
1091501000681	putative Zn2+ binding site [ion binding]; other site
1091501000682	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1091501000683	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1091501000684	Cytochrome P450; Region: p450; cl12078
1091501000685	transcriptional repressor BetI; Region: betaine_BetI; TIGR03384
1091501000686	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1091501000687	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
1091501000688	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1091501000689	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1091501000690	S-adenosylmethionine binding site [chemical binding]; other site
1091501000691	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1091501000692	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1091501000693	potential frameshift: common BLAST hit: gi|340625362|ref|YP_004743814.1| putative dehydrogenase/reductase
1091501000694	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
1091501000695	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
1091501000696	SnoaL-like domain; Region: SnoaL_2; pfam12680
1091501000697	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
1091501000698	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
1091501000699	substrate binding site; other site
1091501000700	tetramer interface; other site
1091501000701	PE family; Region: PE; pfam00934
1091501000702	Domain of unknown function (DUF222); Region: DUF222; pfam02720
1091501000703	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1091501000704	active site
1091501000705	aminotransferase AlaT; Validated; Region: PRK09265
1091501000706	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1091501000707	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1091501000708	homodimer interface [polypeptide binding]; other site
1091501000709	catalytic residue [active]
1091501000710	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
1091501000711	4Fe-4S binding domain; Region: Fer4; pfam00037
1091501000712	Cysteine-rich domain; Region: CCG; pfam02754
1091501000713	Cysteine-rich domain; Region: CCG; pfam02754
1091501000714	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1091501000715	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1091501000716	DNA binding residues [nucleotide binding]
1091501000717	dimerization interface [polypeptide binding]; other site
1091501000718	Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699
1091501000719	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
1091501000720	G1 box; other site
1091501000721	GTP/Mg2+ binding site [chemical binding]; other site
1091501000722	G2 box; other site
1091501000723	Switch I region; other site
1091501000724	G3 box; other site
1091501000725	Switch II region; other site
1091501000726	G4 box; other site
1091501000727	G5 box; other site
1091501000728	potential frameshift: common BLAST hit: gi|340625374|ref|YP_004743826.1| isoniazid inducible gene protein INIC
1091501000729	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1091501000730	active site
1091501000731	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
1091501000732	TIGR04255 family protein; Region: sporadTIGR04255
1091501000733	potential frameshift: common BLAST hit: gi|340625381|ref|YP_004743833.1| putative chaperone protein
1091501000734	Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576
1091501000735	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
1091501000736	dimer interface [polypeptide binding]; other site
1091501000737	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
1091501000738	chaperone protein DnaJ; Provisional; Region: PRK14279
1091501000739	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1091501000740	HSP70 interaction site [polypeptide binding]; other site
1091501000741	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
1091501000742	Zn binding sites [ion binding]; other site
1091501000743	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
1091501000744	dimer interface [polypeptide binding]; other site
1091501000745	Helix-Turn-Helix DNA binding domain of HspR-like transcription regulators; Region: HTH_HspR-like; cd01279
1091501000746	DNA binding residues [nucleotide binding]
1091501000747	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1091501000748	putative dimer interface [polypeptide binding]; other site
1091501000749	potential frameshift: common BLAST hit: gi|224988740|ref|YP_002643427.1| PPE family protein
1091501000750	potential frameshift: common BLAST hit: gi|148821551|ref|YP_001286305.1| PPE family protein
1091501000751	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1091501000752	CoenzymeA binding site [chemical binding]; other site
1091501000753	subunit interaction site [polypeptide binding]; other site
1091501000754	PHB binding site; other site
1091501000755	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
1091501000756	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
1091501000757	GDP-binding site [chemical binding]; other site
1091501000758	ACT binding site; other site
1091501000759	IMP binding site; other site
1091501000760	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
1091501000761	Peptidase family M50; Region: Peptidase_M50; pfam02163
1091501000762	active site
1091501000763	putative substrate binding region [chemical binding]; other site
1091501000764	Protein of unknown function (DUF3151); Region: DUF3151; pfam11349
1091501000765	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
1091501000766	MgtE intracellular N domain; Region: MgtE_N; pfam03448
1091501000767	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
1091501000768	Divalent cation transporter; Region: MgtE; pfam01769
1091501000769	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
1091501000770	fructose-bisphosphate aldolase, class II, yeast/E. coli subtype; Region: FruBisAldo_II_A; TIGR01520
1091501000771	active site
1091501000772	intersubunit interface [polypeptide binding]; other site
1091501000773	zinc binding site [ion binding]; other site
1091501000774	Na+ binding site [ion binding]; other site
1091501000775	Predicted glycosyl hydrolase [Carbohydrate transport and metabolism]; Region: COG4833
1091501000776	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185
1091501000777	AAA domain; Region: AAA_33; pfam13671
1091501000778	Protein of unknown function (DUF3423); Region: DUF3423; pfam11903
1091501000779	VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762
1091501000780	von Willebrand factor (vWF) type A domain; Region: VWA; smart00327
1091501000781	metal ion-dependent adhesion site (MIDAS); other site
1091501000782	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823
1091501000783	putative hydrophobic ligand binding site [chemical binding]; other site
1091501000784	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
1091501000785	Ligand binding site; other site
1091501000786	metal-binding site
1091501000787	potential frameshift: common BLAST hit: gi|340625403|ref|YP_004743855.1| putative carbon monoxide dehydrogenase (large chain)
1091501000788	potential frameshift: common BLAST hit: gi|339630443|ref|YP_004722085.1| carbon monoxide dehydrogenase large subunit
1091501000789	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
1091501000790	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1091501000791	catalytic loop [active]
1091501000792	iron binding site [ion binding]; other site
1091501000793	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
1091501000794	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
1091501000795	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
1091501000796	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
1091501000797	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
1091501000798	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
1091501000799	XdhC Rossmann domain; Region: XdhC_C; pfam13478
1091501000800	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1091501000801	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1091501000802	LysR substrate binding domain; Region: LysR_substrate; pfam03466
1091501000803	dimerization interface [polypeptide binding]; other site
1091501000804	Uncharacterized conserved protein [Function unknown]; Region: COG3360
1091501000805	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
1091501000806	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1091501000807	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1091501000808	active site
1091501000809	potential frameshift: common BLAST hit: gi|339630454|ref|YP_004722096.1| endopeptidase ATP-binding protein subunit B
1091501000810	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
1091501000811	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
1091501000812	heme-binding site [chemical binding]; other site
1091501000813	The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187
1091501000814	FAD binding pocket [chemical binding]; other site
1091501000815	FAD binding motif [chemical binding]; other site
1091501000816	phosphate binding motif [ion binding]; other site
1091501000817	beta-alpha-beta structure motif; other site
1091501000818	NAD binding pocket [chemical binding]; other site
1091501000819	potential frameshift: common BLAST hit: gi|31791563|ref|NP_854056.1| LuxR family transcriptional regulator
1091501000820	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1091501000821	PPE family; Region: PPE; pfam00823
1091501000822	potential frameshift: common BLAST hit: gi|253797311|ref|YP_003030312.1| phosphoribosylglycinamide formyltransferase 2
1091501000823	Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522
1091501000824	active site residue [active]
1091501000825	potential frameshift: common BLAST hit: gi|339630460|ref|YP_004722102.1| O-succinylhomoserine sulfhydrylase
1091501000826	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
1091501000827	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1091501000828	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1091501000829	Domain of unknown function (DUF222); Region: DUF222; pfam02720
1091501000830	potential frameshift: common BLAST hit: gi|224988777|ref|YP_002643464.1| conserved 13E12 repeat family protein
1091501000831	PLD-like domain; Region: PLDc_2; pfam13091
1091501000832	potential frameshift: common BLAST hit: gi|224988783|ref|YP_002643470.1| lipoprotein
1091501000833	Glutaryl-CoA dehydrogenase; Region: GCD; cd01151
1091501000834	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1091501000835	FAD binding site [chemical binding]; other site
1091501000836	substrate binding pocket [chemical binding]; other site
1091501000837	catalytic base [active]
1091501000838	Protein of unknown function (DUF3054); Region: DUF3054; pfam11255
1091501000839	potential frameshift: common BLAST hit: gi|340625428|ref|YP_004743880.1| putative transmembrane transport protein MMPL1
1091501000840	potential frameshift: common BLAST hit: gi|339630471|ref|YP_004722113.1| transporter
1091501000841	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
1091501000842	acyl-CoA synthetase; Validated; Region: PRK05850
1091501000843	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
1091501000844	acyl-activating enzyme (AAE) consensus motif; other site
1091501000845	active site
1091501000846	potential frameshift: common BLAST hit: gi|253797328|ref|YP_003030329.1| membrane bound polyketide synthase pks6
1091501000847	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1091501000848	probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620
1091501000849	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
1091501000850	phosphate acetyltransferase; Reviewed; Region: PRK05632
1091501000851	DRTGG domain; Region: DRTGG; pfam07085
1091501000852	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
1091501000853	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
1091501000854	potential frameshift: common BLAST hit: gi|253797333|ref|YP_003030334.1| serine/threonine-protein kinase pknG
1091501000855	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
1091501000856	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1091501000857	substrate binding pocket [chemical binding]; other site
1091501000858	membrane-bound complex binding site; other site
1091501000859	hinge residues; other site
1091501000860	NUDIX domain; Region: NUDIX; pfam00293
1091501000861	nudix motif; other site
1091501000862	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
1091501000863	thiamine phosphate binding site [chemical binding]; other site
1091501000864	active site
1091501000865	pyrophosphate binding site [ion binding]; other site
1091501000866	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
1091501000867	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
1091501000868	thiS-thiF/thiG interaction site; other site
1091501000869	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
1091501000870	ThiS interaction site; other site
1091501000871	putative active site [active]
1091501000872	tetramer interface [polypeptide binding]; other site
1091501000873	potential frameshift: common BLAST hit: gi|253797342|ref|YP_003030343.1| lipoprotein aminopeptidase lpqL
1091501000874	Predicted metalloprotease [General function prediction only]; Region: COG2321
1091501000875	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
1091501000876	Zn binding site [ion binding]; other site
1091501000877	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
1091501000878	dimer interface [polypeptide binding]; other site
1091501000879	substrate binding site [chemical binding]; other site
1091501000880	ATP binding site [chemical binding]; other site
1091501000881	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
1091501000882	ThiC-associated domain; Region: ThiC-associated; pfam13667
1091501000883	ThiC family; Region: ThiC; pfam01964
1091501000884	potential frameshift: common BLAST hit: gi|339630494|ref|YP_004722136.1| ATPase P
1091501000885	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
1091501000886	putative catalytic site [active]
1091501000887	putative phosphate binding site [ion binding]; other site
1091501000888	active site
1091501000889	metal binding site A [ion binding]; metal-binding site
1091501000890	DNA binding site [nucleotide binding]
1091501000891	putative AP binding site [nucleotide binding]; other site
1091501000892	putative metal binding site B [ion binding]; other site
1091501000893	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
1091501000894	active site
1091501000895	catalytic residues [active]
1091501000896	metal binding site [ion binding]; metal-binding site
1091501000897	Protein of unknown function (DUF3263); Region: DUF3263; pfam11662
1091501000898	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
1091501000899	Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032
1091501000900	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
1091501000901	E-class dimer interface [polypeptide binding]; other site
1091501000902	P-class dimer interface [polypeptide binding]; other site
1091501000903	active site
1091501000904	Cu2+ binding site [ion binding]; other site
1091501000905	Zn2+ binding site [ion binding]; other site
1091501000906	carboxylate-amine ligase; Provisional; Region: PRK13517
1091501000907	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
1091501000908	Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802
1091501000909	potential frameshift: common BLAST hit: gi|253797359|ref|YP_003030360.1| ATPase
1091501000910	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
1091501000911	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
1091501000912	phosphatidylserine decarboxylase; Provisional; Region: PRK05305
1091501000913	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
1091501000914	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
1091501000915	putative MPT binding site; other site
1091501000916	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
1091501000917	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
1091501000918	dimer interface [polypeptide binding]; other site
1091501000919	putative functional site; other site
1091501000920	short chain dehydrogenase; Provisional; Region: PRK06197
1091501000921	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
1091501000922	putative NAD(P) binding site [chemical binding]; other site
1091501000923	active site
1091501000924	chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I...; Region: chaperonin_like; cl02777
1091501000925	chaperonin GroEL; Reviewed; Region: groEL; PRK12852
1091501000926	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
1091501000927	ring oligomerisation interface [polypeptide binding]; other site
1091501000928	ATP/Mg binding site [chemical binding]; other site
1091501000929	stacking interactions; other site
1091501000930	hinge regions; other site
1091501000931	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1091501000932	PPE family; Region: PPE; pfam00823
1091501000933	Protein of unknown function (DUF664); Region: DUF664; pfam04978
1091501000934	DinB superfamily; Region: DinB_2; pfam12867
1091501000935	RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646
1091501000936	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1091501000937	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1091501000938	DNA binding residues [nucleotide binding]
1091501000939	Steroid 5-alpha reductase family enzyme [General function prediction only]; Region: COG3752
1091501000940	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
1091501000941	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1091501000942	S-adenosylmethionine binding site [chemical binding]; other site
1091501000943	Protein of unknown function (DUF1365); Region: DUF1365; cl17838
1091501000944	Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907
1091501000945	Subunit A of Class III extradiol dioxygenases; Region: Extradiol_Dioxygenase_3A_like; cl06673
1091501000946	dimer interface [polypeptide binding]; other site
1091501000947	potential frameshift: common BLAST hit: gi|339630518|ref|YP_004722160.1| transporter
1091501000948	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
1091501000949	potential frameshift: common BLAST hit: gi|339630520|ref|YP_004722162.1| transcriptional regulator
1091501000950	potential frameshift: common BLAST hit: gi|339630521|ref|YP_004722163.1| PPE family protein
1091501000951	Protein of unknown function (DUF2782); Region: DUF2782; pfam11191
1091501000952	enoyl-CoA hydratase; Provisional; Region: PRK12478
1091501000953	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1091501000954	substrate binding site [chemical binding]; other site
1091501000955	oxyanion hole (OAH) forming residues; other site
1091501000956	trimer interface [polypeptide binding]; other site
1091501000957	PemK-like protein; Region: PemK; pfam02452
1091501000958	potential frameshift: common BLAST hit: gi|253797384|ref|YP_003030385.1| peptidase
1091501000959	potential frameshift: common BLAST hit: gi|340625484|ref|YP_004743936.1| putative aldehyde dehydrogenase
1091501000960	Protein of unknown function (DUF779); Region: DUF779; cl01432
1091501000961	potential frameshift: common BLAST hit: gi|340625488|ref|YP_004743940.1| dihydrolipoamide dehydrogenase LPD
1091501000962	Uncharacterized conserved protein [Function unknown]; Region: COG2128
1091501000963	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
1091501000964	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1091501000965	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1091501000966	non-specific DNA binding site [nucleotide binding]; other site
1091501000967	salt bridge; other site
1091501000968	sequence-specific DNA binding site [nucleotide binding]; other site
1091501000969	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
1091501000970	Domain of unknown function (DUF955); Region: DUF955; pfam06114
1091501000971	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
1091501000972	Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884
1091501000973	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1091501000974	active site
1091501000975	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
1091501000976	active site 2 [active]
1091501000977	isocitrate lyase; Provisional; Region: PRK15063
1091501000978	Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cd06556
1091501000979	oligomerization interface [polypeptide binding]; other site
1091501000980	active site
1091501000981	metal binding site [ion binding]; metal-binding site
1091501000982	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819
1091501000983	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1091501000984	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1091501000985	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
1091501000986	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1091501000987	S-adenosylmethionine binding site [chemical binding]; other site
1091501000988	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
1091501000989	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1091501000990	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1091501000991	S-adenosylmethionine binding site [chemical binding]; other site
1091501000992	1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224
1091501000993	UbiA prenyltransferase family; Region: UbiA; pfam01040
1091501000994	potential frameshift: common BLAST hit: gi|340625498|ref|YP_004743950.1| putative transcriptional regulatory protein
1091501000995	Predicted membrane protein [Function unknown]; Region: COG2733
1091501000996	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1091501000997	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1091501000998	non-specific DNA binding site [nucleotide binding]; other site
1091501000999	salt bridge; other site
1091501001000	sequence-specific DNA binding site [nucleotide binding]; other site
1091501001001	Protein of unknown function (DUF2516); Region: DUF2516; pfam10724
1091501001002	Protein of unknown function (DUF2599); Region: DUF2599; pfam10783
1091501001003	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
1091501001004	intersubunit interface [polypeptide binding]; other site
1091501001005	active site
1091501001006	catalytic residue [active]
1091501001007	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
1091501001008	Predicted amidohydrolase [General function prediction only]; Region: COG0388
1091501001009	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581
1091501001010	putative active site [active]
1091501001011	catalytic triad [active]
1091501001012	putative dimer interface [polypeptide binding]; other site
1091501001013	Protein of unknown function (DUF2505); Region: DUF2505; pfam10698
1091501001014	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903
1091501001015	FAD binding domain; Region: FAD_binding_4; pfam01565
1091501001016	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
1091501001017	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431
1091501001018	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
1091501001019	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432
1091501001020	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1091501001021	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
1091501001022	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1091501001023	NAD(P) binding site [chemical binding]; other site
1091501001024	active site
1091501001025	potential frameshift: common BLAST hit: gi|339630555|ref|YP_004722197.1| transcriptional regulator
1091501001026	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
1091501001027	D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449
1091501001028	putative ADP-binding pocket [chemical binding]; other site
1091501001029	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
1091501001030	L-lysine exporter; Region: 2a75; TIGR00948
1091501001031	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1091501001032	catalytic core [active]
1091501001033	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
1091501001034	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1091501001035	dimer interface [polypeptide binding]; other site
1091501001036	phosphorylation site [posttranslational modification]
1091501001037	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1091501001038	ATP binding site [chemical binding]; other site
1091501001039	Mg2+ binding site [ion binding]; other site
1091501001040	G-X-G motif; other site
1091501001041	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1091501001042	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1091501001043	active site
1091501001044	phosphorylation site [posttranslational modification]
1091501001045	intermolecular recognition site; other site
1091501001046	dimerization interface [polypeptide binding]; other site
1091501001047	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1091501001048	DNA binding site [nucleotide binding]
1091501001049	GMC oxidoreductase; Region: GMC_oxred_N; pfam00732
1091501001050	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1091501001051	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1091501001052	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1091501001053	DNA-binding site [nucleotide binding]; DNA binding site
1091501001054	FCD domain; Region: FCD; pfam07729
1091501001055	exopolyphosphatase; Region: exo_poly_only; TIGR03706
1091501001056	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
1091501001057	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1091501001058	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
1091501001059	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
1091501001060	Diacylglycerol kinase catalytic domain (presumed); Region: DAGKc; smart00046
1091501001061	potential frameshift: common BLAST hit: gi|340625527|ref|YP_004743979.1| putative pyrroline-5-carboxylate reductase PROC
1091501001062	DNA binding domain, excisionase family; Region: excise; TIGR01764
1091501001063	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1091501001064	UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240
1091501001065	putative NAD(P) binding site [chemical binding]; other site
1091501001066	active site
1091501001067	putative substrate binding site [chemical binding]; other site
1091501001068	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1091501001069	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
1091501001070	putative acyl-acceptor binding pocket; other site
1091501001071	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
1091501001072	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1091501001073	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1091501001074	S-adenosylmethionine binding site [chemical binding]; other site
1091501001075	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
1091501001076	HAD-superfamily subfamily IB hydrolase, TIGR01490; Region: HAD-SF-IB-hyp1
1091501001077	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
1091501001078	potential frameshift: common BLAST hit: gi|340625535|ref|YP_004743987.1| putative transmembrane transport protein MMPL2
1091501001079	Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768
1091501001080	potential frameshift: common BLAST hit: gi|340625537|ref|YP_004743989.1| putative glutamyl-tRNA reductase HEMA
1091501001081	potential frameshift: common BLAST hit: gi|253797442|ref|YP_003030443.1| porphobilinogen deaminase
1091501001082	S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815
1091501001083	active site
1091501001084	homodimer interface [polypeptide binding]; other site
1091501001085	SAM binding site [chemical binding]; other site
1091501001086	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
1091501001087	dimer interface [polypeptide binding]; other site
1091501001088	active site
1091501001089	Schiff base residues; other site
1091501001090	Domain of unknown function (DUF222); Region: DUF222; pfam02720
1091501001091	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1091501001092	active site
1091501001093	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
1091501001094	anti sigma factor interaction site; other site
1091501001095	regulatory phosphorylation site [posttranslational modification]; other site
1091501001096	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
1091501001097	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
1091501001098	active site
1091501001099	catalytic triad [active]
1091501001100	oxyanion hole [active]
1091501001101	Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382
1091501001102	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1091501001103	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1091501001104	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
1091501001105	Domain of unknown function (DUF385); Region: DUF385; pfam04075
1091501001106	potential frameshift: common BLAST hit: gi|339630596|ref|YP_004722238.1| glutamate-1-semialdehyde 2,1-aminomutase
1091501001107	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
1091501001108	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1091501001109	catalytic residues [active]
1091501001110	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
1091501001111	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
1091501001112	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333
1091501001113	ResB-like family; Region: ResB; pfam05140
1091501001114	cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144
1091501001115	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
1091501001116	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
1091501001117	Protein of unknown function (DUF4229); Region: DUF4229; pfam14012
1091501001118	3-oxoacyl-(acyl-carrier-protein) synthase III; Region: fabH; TIGR00747
1091501001119	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
1091501001120	dimer interface [polypeptide binding]; other site
1091501001121	active site
1091501001122	CoA binding pocket [chemical binding]; other site
1091501001123	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Region: menA; TIGR00751
1091501001124	UbiA prenyltransferase family; Region: UbiA; pfam01040
1091501001125	5'-methylthioadenosine phosphorylase; Validated; Region: PRK07823
1091501001126	potential frameshift: common BLAST hit: gi|340625563|ref|YP_004744015.1| putative UDP-glucose 4-epimerase GALE3
1091501001127	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3222
1091501001128	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1091501001129	AMP binding site [chemical binding]; other site
1091501001130	active site
1091501001131	CoA binding site [chemical binding]; other site
1091501001132	Protein of unknown function (DUF3349); Region: DUF3349; pfam11829
1091501001133	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
1091501001134	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1091501001135	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1091501001136	active site
1091501001137	short chain dehydrogenase; Provisional; Region: PRK05866
1091501001138	classical (c) SDRs; Region: SDR_c; cd05233
1091501001139	NAD(P) binding site [chemical binding]; other site
1091501001140	active site
1091501001141	potential frameshift: common BLAST hit: gi|340625575|ref|YP_004744027.1| putative naphthoate synthase MENB
1091501001142	PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873
1091501001143	putative active site [active]
1091501001144	homotetrameric interface [polypeptide binding]; other site
1091501001145	metal binding site [ion binding]; metal-binding site
1091501001146	Post-segregation antitoxin (ccd killing mechanism protein) encoded by the F plasmid [General function prediction only]; Region: COG5302
1091501001147	acyl-CoA synthetase; Validated; Region: PRK06188
1091501001148	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
1091501001149	putative active site [active]
1091501001150	putative CoA binding site [chemical binding]; other site
1091501001151	putative AMP binding site [chemical binding]; other site
1091501001152	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
1091501001153	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
1091501001154	active site
1091501001155	O-succinylbenzoate synthase; Provisional; Region: PRK02901
1091501001156	o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320
1091501001157	active site
1091501001158	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1091501001159	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
1091501001160	potential frameshift: common BLAST hit: gi|339630625|ref|YP_004722267.1| menaquinone biosynthesis protein MenD
1091501001161	Protein of unknown function (DUF3592); Region: DUF3592; pfam12158
1091501001162	potential frameshift: common BLAST hit: gi|15839955|ref|NP_334992.1| glycosyl transferase family protein
1091501001163	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
1091501001164	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1091501001165	S-adenosylmethionine binding site [chemical binding]; other site
1091501001166	Protein of unknown function (DUF732); Region: DUF732; pfam05305
1091501001167	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1091501001168	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1091501001169	S-adenosylmethionine binding site [chemical binding]; other site
1091501001170	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
1091501001171	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1091501001172	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
1091501001173	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1091501001174	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
1091501001175	substrate binding pocket [chemical binding]; other site
1091501001176	aspartate-rich region 2; other site
1091501001177	substrate-Mg2+ binding site; other site
1091501001178	heat shock protein HtpX; Provisional; Region: PRK03072
1091501001179	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK12439
1091501001180	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
1091501001181	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
1091501001182	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
1091501001183	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
1091501001184	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
1091501001185	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
1091501001186	O-methyltransferase; Region: Methyltransf_2; pfam00891
1091501001187	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1091501001188	Cytochrome P450; Region: p450; cl12078
1091501001189	Domain of unknown function (DUF1918); Region: DUF1918; pfam08940
1091501001190	ATP cone domain; Region: ATP-cone; pfam03477
1091501001191	Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317
1091501001192	ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504
1091501001193	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
1091501001194	active site
1091501001195	dimer interface [polypeptide binding]; other site
1091501001196	effector binding site; other site
1091501001197	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
1091501001198	potential frameshift: common BLAST hit: gi|253797506|ref|YP_003030507.1| nicotinate phosphoribosyltransferase
1091501001199	Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane]; Region: PgsA; COG2843
1091501001200	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
1091501001201	putative active site [active]
1091501001202	putative metal binding site [ion binding]; other site
1091501001203	hypothetical protein; Provisional; Region: PRK07588
1091501001204	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1091501001205	potential frameshift: common BLAST hit: gi|253797509|ref|YP_003030510.1| transcriptional regulator, arsR-family
1091501001206	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
1091501001207	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1091501001208	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
1091501001209	potential frameshift: common BLAST hit: gi|121636496|ref|YP_976719.1| PE-PGRS family protein
1091501001210	Ub domain fused to Mut7-C; Region: Ub-Mut7C; pfam14451
1091501001211	Uncharacterized conserved protein [Function unknown]; Region: COG1656
1091501001212	Protein of unknown function DUF82; Region: DUF82; pfam01927
1091501001213	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
1091501001214	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
1091501001215	Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738
1091501001216	Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537
1091501001217	Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971
1091501001218	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
1091501001219	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1091501001220	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1091501001221	DNA-binding site [nucleotide binding]; DNA binding site
1091501001222	FCD domain; Region: FCD; pfam07729
1091501001223	Permease; Region: Permease; pfam02405
1091501001224	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
1091501001225	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
1091501001226	Permease; Region: Permease; pfam02405
1091501001227	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
1091501001228	mce related protein; Region: MCE; pfam02470
1091501001229	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
1091501001230	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
1091501001231	mce related protein; Region: MCE; pfam02470
1091501001232	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
1091501001233	mce related protein; Region: MCE; pfam02470
1091501001234	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
1091501001235	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
1091501001236	mce related protein; Region: MCE; pfam02470
1091501001237	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
1091501001238	mce related protein; Region: MCE; pfam02470
1091501001239	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
1091501001240	oligomeric interface; other site
1091501001241	putative active site [active]
1091501001242	homodimer interface [polypeptide binding]; other site
1091501001243	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
1091501001244	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
1091501001245	AAA domain; Region: AAA_14; pfam13173
1091501001246	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
1091501001247	looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439
1091501001248	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1091501001249	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1091501001250	ATP binding site [chemical binding]; other site
1091501001251	Mg2+ binding site [ion binding]; other site
1091501001252	G-X-G motif; other site
1091501001253	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1091501001254	dimerization interface [polypeptide binding]; other site
1091501001255	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
1091501001256	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1091501001257	active site
1091501001258	phosphorylation site [posttranslational modification]
1091501001259	intermolecular recognition site; other site
1091501001260	dimerization interface [polypeptide binding]; other site
1091501001261	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1091501001262	DNA binding site [nucleotide binding]
1091501001263	Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485
1091501001264	Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485
1091501001265	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
1091501001266	Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769
1091501001267	catalytic residues [active]
1091501001268	catalytic nucleophile [active]
1091501001269	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
1091501001270	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
1091501001271	Probable transposase; Region: OrfB_IS605; pfam01385
1091501001272	Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704
1091501001273	PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871
1091501001274	putative active site [active]
1091501001275	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB-like; cd09875
1091501001276	putative active site [active]
1091501001277	Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608
1091501001278	dimer interface [polypeptide binding]; other site
1091501001279	Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085
1091501001280	active site
1091501001281	potential frameshift: common BLAST hit: gi|253797558|ref|YP_003030559.1| galactokinase
1091501001282	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4423
1091501001283	PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871
1091501001284	putative active site [active]
1091501001285	Uncharacterized conserved protein [Function unknown]; Region: COG0398
1091501001286	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1091501001287	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
1091501001288	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
1091501001289	oligomeric interface; other site
1091501001290	putative active site [active]
1091501001291	homodimer interface [polypeptide binding]; other site
1091501001292	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398
1091501001293	FIST N domain; Region: FIST; pfam08495
1091501001294	FIST C domain; Region: FIST_C; pfam10442
1091501001295	exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447
1091501001296	AAA domain; Region: AAA_30; pfam13604
1091501001297	Family description; Region: UvrD_C_2; pfam13538
1091501001298	potential frameshift: common BLAST hit: gi|253797569|ref|YP_003030570.1| exonuclease subunit V gamma recC
1091501001299	potential frameshift: common BLAST hit: gi|148660403|ref|YP_001281926.1| exodeoxyribonuclease V subunit gamma
1091501001300	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
1091501001301	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1091501001302	substrate binding site [chemical binding]; other site
1091501001303	oxyanion hole (OAH) forming residues; other site
1091501001304	trimer interface [polypeptide binding]; other site
1091501001305	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
1091501001306	Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450
1091501001307	50S ribosomal protein L33; Validated; Region: rpmG; PRK00504
1091501001308	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
1091501001309	active site
1091501001310	catalytic site [active]
1091501001311	SAV4209_like.  Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453
1091501001312	active site
1091501001313	catalytic site [active]
1091501001314	potential frameshift: common BLAST hit: gi|253797577|ref|YP_003030578.1| (3R)-hydroxyacyl-ACP dehydratase subunit HadC
1091501001315	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
1091501001316	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
1091501001317	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
1091501001318	putative homodimer interface [polypeptide binding]; other site
1091501001319	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
1091501001320	heterodimer interface [polypeptide binding]; other site
1091501001321	homodimer interface [polypeptide binding]; other site
1091501001322	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
1091501001323	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
1091501001324	23S rRNA interface [nucleotide binding]; other site
1091501001325	L7/L12 interface [polypeptide binding]; other site
1091501001326	putative thiostrepton binding site; other site
1091501001327	L25 interface [polypeptide binding]; other site
1091501001328	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cl00322
1091501001329	mRNA/rRNA interface [nucleotide binding]; other site
1091501001330	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
1091501001331	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
1091501001332	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1091501001333	S-adenosylmethionine binding site [chemical binding]; other site
1091501001334	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
1091501001335	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1091501001336	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1091501001337	S-adenosylmethionine binding site [chemical binding]; other site
1091501001338	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
1091501001339	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1091501001340	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1091501001341	S-adenosylmethionine binding site [chemical binding]; other site
1091501001342	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1091501001343	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1091501001344	S-adenosylmethionine binding site [chemical binding]; other site
1091501001345	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1091501001346	TAP-like protein; Region: Abhydrolase_4; pfam08386
1091501001347	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
1091501001348	ABC1 family; Region: ABC1; cl17513
1091501001349	N-terminal catalytic domain of class II alpha-mannosidases and similar proteins; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_like; cd10786
1091501001350	active site
1091501001351	catalytic site [active]
1091501001352	Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383
1091501001353	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872
1091501001354	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1091501001355	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1091501001356	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
1091501001357	23S rRNA interface [nucleotide binding]; other site
1091501001358	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
1091501001359	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
1091501001360	core dimer interface [polypeptide binding]; other site
1091501001361	peripheral dimer interface [polypeptide binding]; other site
1091501001362	L10 interface [polypeptide binding]; other site
1091501001363	L11 interface [polypeptide binding]; other site
1091501001364	putative EF-Tu interaction site [polypeptide binding]; other site
1091501001365	putative EF-G interaction site [polypeptide binding]; other site
1091501001366	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1091501001367	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1091501001368	WHG domain; Region: WHG; pfam13305
1091501001369	potential frameshift: common BLAST hit: gi|253797594|ref|YP_003030595.1| dioxygenase
1091501001370	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
1091501001371	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
1091501001372	Walker A/P-loop; other site
1091501001373	ATP binding site [chemical binding]; other site
1091501001374	Q-loop/lid; other site
1091501001375	ABC transporter signature motif; other site
1091501001376	Walker B; other site
1091501001377	D-loop; other site
1091501001378	H-loop/switch region; other site
1091501001379	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
1091501001380	putative active site [active]
1091501001381	Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450
1091501001382	Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266
1091501001383	hypothetical protein; Provisional; Region: PRK06834
1091501001384	Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337
1091501001385	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG1848
1091501001386	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
1091501001387	Sulfatase; Region: Sulfatase; pfam00884
1091501001388	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
1091501001389	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
1091501001390	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
1091501001391	putative active site [active]
1091501001392	potential frameshift: common BLAST hit: gi|224989060|ref|YP_002643747.1| DNA-directed RNA polymerase subunit beta
1091501001393	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
1091501001394	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
1091501001395	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
1091501001396	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
1091501001397	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
1091501001398	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
1091501001399	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
1091501001400	G-loop; other site
1091501001401	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
1091501001402	DNA binding site [nucleotide binding]
1091501001403	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
1091501001404	Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712
1091501001405	endonuclease IV; Provisional; Region: PRK01060
1091501001406	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
1091501001407	AP (apurinic/apyrimidinic) site pocket; other site
1091501001408	DNA interaction; other site
1091501001409	Metal-binding active site; metal-binding site
1091501001410	Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509
1091501001411	Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181
1091501001412	isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561
1091501001413	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1091501001414	active site
1091501001415	enoyl-CoA hydratase; Provisional; Region: PRK12478
1091501001416	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1091501001417	substrate binding site [chemical binding]; other site
1091501001418	oxyanion hole (OAH) forming residues; other site
1091501001419	trimer interface [polypeptide binding]; other site
1091501001420	Phenylacetic acid-responsive transcriptional repressor [Transcription]; Region: PaaX; COG3327
1091501001421	PaaX-like protein; Region: PaaX; pfam07848
1091501001422	PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223
1091501001423	potential frameshift: common BLAST hit: gi|339630745|ref|YP_004722387.1| enoyl-CoA hydratase
1091501001424	Transport protein; Region: actII; TIGR00833
1091501001425	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
1091501001426	Protein of unknown function (DUF3060); Region: DUF3060; pfam11259
1091501001427	Protein of unknown function (DUF3060); Region: DUF3060; pfam11259
1091501001428	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1091501001429	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1091501001430	WHG domain; Region: WHG; pfam13305
1091501001431	potential frameshift: common BLAST hit: gi|340625701|ref|YP_004744153.1| putative 30S ribosomal protein S12 RPSL
1091501001432	30S ribosomal protein S7; Validated; Region: PRK05302
1091501001433	potential frameshift: common BLAST hit: gi|340625703|ref|YP_004744155.1| putative elongation factor G FUSA1 (EF-G)
1091501001434	potential frameshift: common BLAST hit: gi|340625703|ref|YP_004744155.1| putative elongation factor G FUSA1 (EF-G)
1091501001435	elongation factor Tu; Reviewed; Region: PRK00049
1091501001436	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
1091501001437	G1 box; other site
1091501001438	GEF interaction site [polypeptide binding]; other site
1091501001439	GTP/Mg2+ binding site [chemical binding]; other site
1091501001440	Switch I region; other site
1091501001441	G2 box; other site
1091501001442	G3 box; other site
1091501001443	Switch II region; other site
1091501001444	G4 box; other site
1091501001445	G5 box; other site
1091501001446	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
1091501001447	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
1091501001448	Antibiotic Binding Site [chemical binding]; other site
1091501001449	Short C-terminal domain; Region: SHOCT; pfam09851
1091501001450	potential frameshift: common BLAST hit: gi|340625706|ref|YP_004744158.1| putative short-chain type dehydrogenase/reductase
1091501001451	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
1091501001452	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1091501001453	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4427
1091501001454	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
1091501001455	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1091501001456	putative mycofactocin binding protein MftB; Region: mycofact_MftB; TIGR03967
1091501001457	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
1091501001458	heme/flavin dehydrogenase, mycofactocin system; Region: actino_HemFlav; TIGR03966
1091501001459	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1091501001460	phosphate binding site [ion binding]; other site
1091501001461	mycofactocin system creatininase family protein; Region: mycofact_creat; TIGR03964
1091501001462	mycofactocin system glycosyltransferase; Region: mycofact_glyco; TIGR03965
1091501001463	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
1091501001464	Probable Catalytic site; other site
1091501001465	metal-binding site
1091501001466	dehydrogenase, Rv0697 family; Region: Rv0697; TIGR03970
1091501001467	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1091501001468	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
1091501001469	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
1091501001470	potential frameshift: common BLAST hit: gi|340625721|ref|YP_004744173.1| putative 50S ribosomal protein L3 RPLC
1091501001471	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
1091501001472	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
1091501001473	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
1091501001474	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
1091501001475	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
1091501001476	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
1091501001477	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
1091501001478	putative translocon binding site; other site
1091501001479	protein-rRNA interface [nucleotide binding]; other site
1091501001480	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
1091501001481	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
1091501001482	G-X-X-G motif; other site
1091501001483	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
1091501001484	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
1091501001485	23S rRNA interface [nucleotide binding]; other site
1091501001486	5S rRNA interface [nucleotide binding]; other site
1091501001487	putative antibiotic binding site [chemical binding]; other site
1091501001488	L25 interface [polypeptide binding]; other site
1091501001489	L27 interface [polypeptide binding]; other site
1091501001490	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
1091501001491	putative translocon interaction site; other site
1091501001492	23S rRNA interface [nucleotide binding]; other site
1091501001493	signal recognition particle (SRP54) interaction site; other site
1091501001494	L23 interface [polypeptide binding]; other site
1091501001495	trigger factor interaction site; other site
1091501001496	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
1091501001497	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
1091501001498	Sulfatase; Region: Sulfatase; pfam00884
1091501001499	Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl17353
1091501001500	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
1091501001501	Uncharacterized conserved protein [Function unknown]; Region: COG1262
1091501001502	potential frameshift: common BLAST hit: gi|224989107|ref|YP_002643794.1| transmembrane protein
1091501001503	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
1091501001504	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
1091501001505	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
1091501001506	RNA binding site [nucleotide binding]; other site
1091501001507	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
1091501001508	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
1091501001509	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
1091501001510	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
1091501001511	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
1091501001512	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
1091501001513	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1091501001514	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1091501001515	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
1091501001516	5S rRNA interface [nucleotide binding]; other site
1091501001517	23S rRNA interface [nucleotide binding]; other site
1091501001518	L5 interface [polypeptide binding]; other site
1091501001519	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
1091501001520	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
1091501001521	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
1091501001522	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
1091501001523	23S rRNA binding site [nucleotide binding]; other site
1091501001524	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
1091501001525	potential frameshift: common BLAST hit: gi|253797667|ref|YP_003030668.1| protease IV sppA
1091501001526	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
1091501001527	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
1091501001528	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
1091501001529	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
1091501001530	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398
1091501001531	intersubunit interface [polypeptide binding]; other site
1091501001532	active site
1091501001533	Zn2+ binding site [ion binding]; other site
1091501001534	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
1091501001535	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
1091501001536	NAD binding site [chemical binding]; other site
1091501001537	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1091501001538	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1091501001539	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1091501001540	Coenzyme A binding pocket [chemical binding]; other site
1091501001541	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
1091501001542	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
1091501001543	potential frameshift: common BLAST hit: gi|340625753|ref|YP_004744205.1| putative preprotein translocase SECY
1091501001544	adenylate kinase; Reviewed; Region: adk; PRK00279
1091501001545	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
1091501001546	AMP-binding site [chemical binding]; other site
1091501001547	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
1091501001548	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
1091501001549	active site
1091501001550	RNA polymerase sigma factor SigL; Provisional; Region: PRK09645
1091501001551	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1091501001552	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1091501001553	DNA binding residues [nucleotide binding]
1091501001554	Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662
1091501001555	Putative zinc-finger; Region: zf-HC2; pfam13490
1091501001556	MarR family; Region: MarR; pfam01047
1091501001557	TIGR03086 family protein; Region: TIGR03086
1091501001558	Domain of unknown function (DUF4226); Region: DUF4226; pfam10774
1091501001559	PE family; Region: PE; pfam00934
1091501001560	Helix-turn-helix domain; Region: HTH_17; pfam12728
1091501001561	3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692
1091501001562	potential frameshift: common BLAST hit: gi|57116773|ref|YP_177750.1| PE-PGRS family protein
1091501001563	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
1091501001564	Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028
1091501001565	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1091501001566	3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692
1091501001567	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1091501001568	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1091501001569	active site
1091501001570	potential frameshift: common BLAST hit: gi|340625772|ref|YP_004744224.1| putative methylmalonate-semialdehyde dehydrogenase MMSA
1091501001571	potential frameshift: common BLAST hit: gi|15840168|ref|NP_335205.1| PE PGRS family protein
1091501001572	potential frameshift: common BLAST hit: gi|148660530|ref|YP_001282053.1| PE-PGRS family protein
1091501001573	potential frameshift: common BLAST hit: gi|339630824|ref|YP_004722466.1| PPE family protein
1091501001574	Helix-turn-helix domain; Region: HTH_28; pfam13518
1091501001575	Winged helix-turn helix; Region: HTH_29; pfam13551
1091501001576	potential frameshift: common BLAST hit: gi|340625776|ref|YP_004744228.1| putative two component system response transcriptional positive
1091501001577	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1091501001578	dimerization interface [polypeptide binding]; other site
1091501001579	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1091501001580	dimer interface [polypeptide binding]; other site
1091501001581	phosphorylation site [posttranslational modification]
1091501001582	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1091501001583	ATP binding site [chemical binding]; other site
1091501001584	Mg2+ binding site [ion binding]; other site
1091501001585	G-X-G motif; other site
1091501001586	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
1091501001587	nucleotide binding site/active site [active]
1091501001588	HIT family signature motif; other site
1091501001589	catalytic residue [active]
1091501001590	Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136
1091501001591	potential frameshift: common BLAST hit: gi|340625780|ref|YP_004744232.1| putative Zinc-containing alcohol dehydrogenase NAD dependent ADHB
1091501001592	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
1091501001593	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1091501001594	Cytochrome P450; Region: p450; cl12078
1091501001595	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1091501001596	Cytochrome P450; Region: p450; cl12078
1091501001597	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1091501001598	aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284
1091501001599	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089
1091501001600	NAD binding site [chemical binding]; other site
1091501001601	catalytic residues [active]
1091501001602	short chain dehydrogenase; Provisional; Region: PRK07774
1091501001603	classical (c) SDRs; Region: SDR_c; cd05233
1091501001604	NAD(P) binding site [chemical binding]; other site
1091501001605	active site
1091501001606	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
1091501001607	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
1091501001608	potential frameshift: common BLAST hit: gi|339630842|ref|YP_004722484.1| phosphoribosylamine--glycine ligase
1091501001609	potential frameshift: common BLAST hit: gi|339630843|ref|YP_004722485.1| acylase
1091501001610	potential frameshift: common BLAST hit: gi|339630843|ref|YP_004722485.1| acylase
1091501001611	Predicted esterase [General function prediction only]; Region: COG0627
1091501001612	S-formylglutathione hydrolase; Region: PLN02442
1091501001613	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226
1091501001614	Predicted nuclease (RNAse H fold) [General function prediction only]; Region: COG4328
1091501001615	Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013
1091501001616	Lyase; Region: Lyase_1; pfam00206
1091501001617	tetramer interface [polypeptide binding]; other site
1091501001618	potential frameshift: common BLAST hit: gi|339630848|ref|YP_004722490.1| cytochrome P450
1091501001619	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
1091501001620	ATP binding site [chemical binding]; other site
1091501001621	active site
1091501001622	substrate binding site [chemical binding]; other site
1091501001623	potential frameshift: common BLAST hit: gi|339630851|ref|YP_004722493.1| oligopeptidase B
1091501001624	potential frameshift: common BLAST hit: gi|224989178|ref|YP_002643865.1| multidrug resistance integral membrane efflux protein
1091501001625	Predicted deacetylase [General function prediction only]; Region: COG3233
1091501001626	Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374
1091501001627	putative active site [active]
1091501001628	putative Zn binding site [ion binding]; other site
1091501001629	FAD binding domain; Region: FAD_binding_2; pfam00890
1091501001630	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
1091501001631	potential frameshift: common BLAST hit: gi|253797732|ref|YP_003030733.1| FAD-binding dehydrogenase
1091501001632	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
1091501001633	Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483
1091501001634	phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974
1091501001635	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
1091501001636	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
1091501001637	putative active site [active]
1091501001638	catalytic triad [active]
1091501001639	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
1091501001640	Transglutaminase/protease-like homologues; Region: TGc; smart00460
1091501001641	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1091501001642	probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560
1091501001643	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
1091501001644	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1091501001645	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1091501001646	DNA-binding site [nucleotide binding]; DNA binding site
1091501001647	UTRA domain; Region: UTRA; pfam07702
1091501001648	Uncharacterized conserved protein [Function unknown]; Region: COG1359
1091501001649	potential frameshift: common BLAST hit: gi|339630863|ref|YP_004722505.1| oxidoreductase
1091501001650	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1091501001651	Transposase; Region: HTH_Tnp_1; cl17663
1091501001652	putative transposase OrfB; Reviewed; Region: PHA02517
1091501001653	HTH-like domain; Region: HTH_21; pfam13276
1091501001654	Integrase core domain; Region: rve; pfam00665
1091501001655	Integrase core domain; Region: rve_3; pfam13683
1091501001656	potential frameshift: common BLAST hit: gi|15840209|ref|NP_335246.1| IS1547 transposase
1091501001657	Uncharacterized protein, linocin/CFP29 homolog [Function unknown]; Region: COG1659
1091501001658	Dyp-type peroxidase family; Region: Dyp_perox; pfam04261
1091501001659	M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658
1091501001660	Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127
1091501001661	active site
1091501001662	metal binding site [ion binding]; metal-binding site
1091501001663	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1091501001664	active site
1091501001665	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1091501001666	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1091501001667	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1091501001668	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
1091501001669	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
1091501001670	dimerization interface [polypeptide binding]; other site
1091501001671	ATP binding site [chemical binding]; other site
1091501001672	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
1091501001673	dimerization interface [polypeptide binding]; other site
1091501001674	ATP binding site [chemical binding]; other site
1091501001675	CAAX protease self-immunity; Region: Abi; pfam02517
1091501001676	Protein of unknown function (DUF3184); Region: DUF3184; pfam11380
1091501001677	potential frameshift: common BLAST hit: gi|339630874|ref|YP_004722516.1| amidophosphoribosyltransferase
1091501001678	potential frameshift: common BLAST hit: gi|339630875|ref|YP_004722517.1| phosphoribosylformylglycinamidine cyclo-ligase
1091501001679	Protein of unknown function (DUF3073); Region: DUF3073; pfam11273
1091501001680	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
1091501001681	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
1091501001682	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1091501001683	catalytic residue [active]
1091501001684	nitrobindin heme-binding domain; Region: nitrobindin; cd07828
1091501001685	heme-binding site [chemical binding]; other site
1091501001686	Protein of unknown function (DUF1416); Region: DUF1416; pfam07210
1091501001687	potential frameshift: common BLAST hit: gi|339633125|ref|YP_004724767.1| thiosulfate sulfurtransferase
1091501001688	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1091501001689	catalytic residues [active]
1091501001690	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
1091501001691	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1091501001692	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1091501001693	DNA binding site [nucleotide binding]
1091501001694	mycothiol synthase; Region: mycothiol_MshD; TIGR03448
1091501001695	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1091501001696	Coenzyme A binding pocket [chemical binding]; other site
1091501001697	phosphate transporter ATP-binding protein; Provisional; Region: PRK14241
1091501001698	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
1091501001699	Walker A/P-loop; other site
1091501001700	ATP binding site [chemical binding]; other site
1091501001701	Q-loop/lid; other site
1091501001702	ABC transporter signature motif; other site
1091501001703	Walker B; other site
1091501001704	D-loop; other site
1091501001705	H-loop/switch region; other site
1091501001706	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
1091501001707	PhoU domain; Region: PhoU; pfam01895
1091501001708	PhoU domain; Region: PhoU; pfam01895
1091501001709	cell envelope-related function transcriptional attenuator common domain; Region: lytR_cpsA_psr; TIGR00350
1091501001710	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
1091501001711	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
1091501001712	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
1091501001713	FMN binding site [chemical binding]; other site
1091501001714	active site
1091501001715	catalytic residues [active]
1091501001716	substrate binding site [chemical binding]; other site
1091501001717	Fatty acid desaturase; Region: FA_desaturase_2; pfam03405
1091501001718	Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050
1091501001719	homodimer interface [polypeptide binding]; other site
1091501001720	putative substrate binding pocket [chemical binding]; other site
1091501001721	diiron center [ion binding]; other site
1091501001722	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662
1091501001723	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1091501001724	dimerization interface [polypeptide binding]; other site
1091501001725	putative DNA binding site [nucleotide binding]; other site
1091501001726	putative Zn2+ binding site [ion binding]; other site
1091501001727	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
1091501001728	dimer interface [polypeptide binding]; other site
1091501001729	catalytic motif [active]
1091501001730	nucleoside/Zn binding site; other site
1091501001731	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
1091501001732	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
1091501001733	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
1091501001734	PE family; Region: PE; pfam00934
1091501001735	PE family; Region: PE; pfam00934
1091501001736	PknH-like extracellular domain; Region: PknH_C; pfam14032
1091501001737	Predicted nucleotidyltransferase [General function prediction    only]; Region: COG4849
1091501001738	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4861
1091501001739	Uncharacterized protein conserved in bacteria (DUF2186); Region: DUF2186; pfam09952
1091501001740	D-ala-D-ala dipeptidase; Region: Peptidase_M15; pfam01427
1091501001741	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1091501001742	S-adenosylmethionine binding site [chemical binding]; other site
1091501001743	proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250
1091501001744	potential frameshift: common BLAST hit: gi|148822050|ref|YP_001286804.1| integral membrane protein
1091501001745	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
1091501001746	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
1091501001747	tetramer interface [polypeptide binding]; other site
1091501001748	TPP-binding site [chemical binding]; other site
1091501001749	heterodimer interface [polypeptide binding]; other site
1091501001750	phosphorylation loop region [posttranslational modification]
1091501001751	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1091501001752	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1091501001753	active site
1091501001754	phosphorylation site [posttranslational modification]
1091501001755	intermolecular recognition site; other site
1091501001756	dimerization interface [polypeptide binding]; other site
1091501001757	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1091501001758	DNA binding residues [nucleotide binding]
1091501001759	dimerization interface [polypeptide binding]; other site
1091501001760	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1091501001761	potential frameshift: common BLAST hit: gi|339630911|ref|YP_004722553.1| oxidase
1091501001762	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1091501001763	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
1091501001764	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1091501001765	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1091501001766	multidrug resistance protein MdtH; Provisional; Region: PRK11646
1091501001767	putative substrate translocation pore; other site
1091501001768	short chain dehydrogenase; Provisional; Region: PRK05876
1091501001769	classical (c) SDRs; Region: SDR_c; cd05233
1091501001770	NAD(P) binding site [chemical binding]; other site
1091501001771	active site
1091501001772	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1091501001773	Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961
1091501001774	Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038
1091501001775	dimer interface [polypeptide binding]; other site
1091501001776	PYR/PP interface [polypeptide binding]; other site
1091501001777	TPP binding site [chemical binding]; other site
1091501001778	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1091501001779	Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005
1091501001780	TPP-binding site [chemical binding]; other site
1091501001781	dimer interface [polypeptide binding]; other site
1091501001782	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819
1091501001783	putative hydrophobic ligand binding site [chemical binding]; other site
1091501001784	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
1091501001785	CoA-transferase family III; Region: CoA_transf_3; pfam02515
1091501001786	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819
1091501001787	putative hydrophobic ligand binding site [chemical binding]; other site
1091501001788	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819
1091501001789	putative hydrophobic ligand binding site [chemical binding]; other site
1091501001790	potential frameshift: common BLAST hit: gi|340625872|ref|YP_004744324.1| putative aminotransferase
1091501001791	acetyl-CoA acetyltransferase; Validated; Region: PRK08242
1091501001792	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1091501001793	dimer interface [polypeptide binding]; other site
1091501001794	active site
1091501001795	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730
1091501001796	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1091501001797	substrate binding site [chemical binding]; other site
1091501001798	oxyanion hole (OAH) forming residues; other site
1091501001799	trimer interface [polypeptide binding]; other site
1091501001800	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1091501001801	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1091501001802	Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625
1091501001803	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
1091501001804	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1091501001805	ATP binding site [chemical binding]; other site
1091501001806	putative Mg++ binding site [ion binding]; other site
1091501001807	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1091501001808	nucleotide binding region [chemical binding]; other site
1091501001809	ATP-binding site [chemical binding]; other site
1091501001810	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
1091501001811	trimer interface [polypeptide binding]; other site
1091501001812	dimer interface [polypeptide binding]; other site
1091501001813	putative active site [active]
1091501001814	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
1091501001815	MPT binding site; other site
1091501001816	trimer interface [polypeptide binding]; other site
1091501001817	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
1091501001818	MoaE homodimer interface [polypeptide binding]; other site
1091501001819	MoaD interaction [polypeptide binding]; other site
1091501001820	active site residues [active]
1091501001821	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
1091501001822	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
1091501001823	MoaE interaction surface [polypeptide binding]; other site
1091501001824	MoeB interaction surface [polypeptide binding]; other site
1091501001825	thiocarboxylated glycine; other site
1091501001826	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
1091501001827	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1091501001828	FeS/SAM binding site; other site
1091501001829	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
1091501001830	Predicted membrane protein [Function unknown]; Region: COG3304
1091501001831	Domain of unknown function (DUF307); Region: DUF307; pfam03733
1091501001832	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1091501001833	DNA-binding site [nucleotide binding]; DNA binding site
1091501001834	RNA-binding motif; other site
1091501001835	PE family; Region: PE; pfam00934
1091501001836	potential frameshift: common BLAST hit: gi|339630938|ref|YP_004722580.1| acyl-CoA dehydrogenase
1091501001837	potential frameshift: common BLAST hit: gi|339630938|ref|YP_004722580.1| acyl-CoA dehydrogenase
1091501001838	potential frameshift: common BLAST hit: gi|339630938|ref|YP_004722580.1| acyl-CoA dehydrogenase
1091501001839	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398
1091501001840	FIST N domain; Region: FIST; pfam08495
1091501001841	FIST C domain; Region: FIST_C; pfam10442
1091501001842	Protein of unknown function (DUF2771); Region: DUF2771; pfam10969
1091501001843	potential frameshift: common BLAST hit: gi|224989270|ref|YP_002643957.1| transmembrane protein
1091501001844	Protein of unknown function (DUF3027); Region: DUF3027; pfam11228
1091501001845	potential frameshift: common BLAST hit: gi|224989272|ref|YP_002643959.1| PPE family protein
1091501001846	Protein of unknown function (DUF2530); Region: DUF2530; pfam10745
1091501001847	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1091501001848	MarR family; Region: MarR; pfam01047
1091501001849	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1091501001850	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
1091501001851	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1091501001852	Protein of unknown function (DUF2537); Region: DUF2537; pfam10801
1091501001853	Protein of unknown function (DUF3071); Region: DUF3071; pfam11268
1091501001854	phosphoserine aminotransferase, putative; Region: serC_3; TIGR01366
1091501001855	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1091501001856	catalytic residue [active]
1091501001857	P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583
1091501001858	potential frameshift: common BLAST hit: gi|340625898|ref|YP_004744350.1| putative NADPH:adrenodoxin oxidoreductase FPRB
1091501001859	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
1091501001860	putative dimer interface [polypeptide binding]; other site
1091501001861	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1091501001862	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
1091501001863	putative catalytic site [active]
1091501001864	putative phosphate binding site [ion binding]; other site
1091501001865	putative metal binding site [ion binding]; other site
1091501001866	potential frameshift: common BLAST hit: gi|339630954|ref|YP_004722596.1| citrate synthase
1091501001867	potential frameshift: common BLAST hit: gi|339630955|ref|YP_004722597.1| LuxR family transcriptional regulator
1091501001868	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
1091501001869	cyclase homology domain; Region: CHD; cd07302
1091501001870	nucleotidyl binding site; other site
1091501001871	metal binding site [ion binding]; metal-binding site
1091501001872	dimer interface [polypeptide binding]; other site
1091501001873	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
1091501001874	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
1091501001875	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
1091501001876	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
1091501001877	AAA ATPase domain; Region: AAA_16; pfam13191
1091501001878	Predicted ATPase [General function prediction only]; Region: COG3903
1091501001879	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
1091501001880	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
1091501001881	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
1091501001882	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
1091501001883	dimer interface [polypeptide binding]; other site
1091501001884	active site
1091501001885	citrylCoA binding site [chemical binding]; other site
1091501001886	NADH binding [chemical binding]; other site
1091501001887	cationic pore residues; other site
1091501001888	oxalacetate/citrate binding site [chemical binding]; other site
1091501001889	coenzyme A binding site [chemical binding]; other site
1091501001890	catalytic triad [active]
1091501001891	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
1091501001892	Protein of unknown function (DUF2630); Region: DUF2630; pfam10944
1091501001893	BON domain; Region: BON; pfam04972
1091501001894	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
1091501001895	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1091501001896	ligand binding site [chemical binding]; other site
1091501001897	Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325
1091501001898	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1091501001899	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1091501001900	dimerization interface [polypeptide binding]; other site
1091501001901	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1091501001902	dimer interface [polypeptide binding]; other site
1091501001903	phosphorylation site [posttranslational modification]
1091501001904	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1091501001905	Mg2+ binding site [ion binding]; other site
1091501001906	G-X-G motif; other site
1091501001907	potential frameshift: common BLAST hit: gi|340625914|ref|YP_004744366.1| two component response transcriptional regulatory protein PRRA
1091501001908	potential frameshift: common BLAST hit: gi|340625915|ref|YP_004744367.1| putative acetyl-coenzyme A carboxylase carboxyl transferase subunit
1091501001909	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
1091501001910	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1091501001911	substrate binding site [chemical binding]; other site
1091501001912	oxyanion hole (OAH) forming residues; other site
1091501001913	trimer interface [polypeptide binding]; other site
1091501001914	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1091501001915	Beta-lactamase; Region: Beta-lactamase; pfam00144
1091501001916	Domain of unknown function (DUF3471); Region: DUF3471; pfam11954
1091501001917	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1091501001918	ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494
1091501001919	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1091501001920	MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013
1091501001921	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
1091501001922	hydrophobic ligand binding site; other site
1091501001923	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
1091501001924	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1091501001925	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
1091501001926	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1091501001927	potential frameshift: common BLAST hit: gi|340625924|ref|YP_004744376.1| putative dioxygenase
1091501001928	potential frameshift: common BLAST hit: gi|339630977|ref|YP_004722619.1| keto acyl-CoA thiolase
1091501001929	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1091501001930	PPE family; Region: PPE; pfam00823
1091501001931	potential frameshift: common BLAST hit: gi|339630980|ref|YP_004722622.1| glycine/betaine ABC transporter
1091501001932	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453
1091501001933	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1091501001934	MULE transposase domain; Region: MULE; pfam10551
1091501001935	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
1091501001936	Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769
1091501001937	catalytic residues [active]
1091501001938	catalytic nucleophile [active]
1091501001939	potential frameshift: common BLAST hit: gi|340625933|ref|YP_004744385.1| putative transposase
1091501001940	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
1091501001941	putative active site pocket [active]
1091501001942	dimerization interface [polypeptide binding]; other site
1091501001943	putative catalytic residue [active]
1091501001944	Protein of unknown function (DUF867); Region: DUF867; cl01713
1091501001945	manganese transport protein MntH; Reviewed; Region: PRK00701
1091501001946	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
1091501001947	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
1091501001948	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1091501001949	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
1091501001950	short chain dehydrogenase; Provisional; Region: PRK07814
1091501001951	classical (c) SDRs; Region: SDR_c; cd05233
1091501001952	NAD(P) binding site [chemical binding]; other site
1091501001953	active site
1091501001954	potential frameshift: common BLAST hit: gi|15840351|ref|NP_335388.1| phosphate ABC transporter substrate-binding protein
1091501001955	phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138
1091501001956	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1091501001957	dimer interface [polypeptide binding]; other site
1091501001958	conserved gate region; other site
1091501001959	putative PBP binding loops; other site
1091501001960	ABC-ATPase subunit interface; other site
1091501001961	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
1091501001962	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1091501001963	ABC-ATPase subunit interface; other site
1091501001964	potential frameshift: common BLAST hit: gi|340625940|ref|YP_004744392.1| transmembrane serine/threonine-protein kinase D
1091501001965	PBP superfamily domain; Region: PBP_like_2; cl17296
1091501001966	phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14271
1091501001967	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
1091501001968	Walker A/P-loop; other site
1091501001969	ATP binding site [chemical binding]; other site
1091501001970	Q-loop/lid; other site
1091501001971	ABC transporter signature motif; other site
1091501001972	Walker B; other site
1091501001973	D-loop; other site
1091501001974	H-loop/switch region; other site
1091501001975	phosphate ABC transporter, phosphate-binding protein; Region: 3a0107s03; TIGR00975
1091501001976	phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138
1091501001977	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1091501001978	dimer interface [polypeptide binding]; other site
1091501001979	conserved gate region; other site
1091501001980	putative PBP binding loops; other site
1091501001981	ABC-ATPase subunit interface; other site
1091501001982	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1091501001983	ABC-ATPase subunit interface; other site
1091501001984	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
1091501001985	putative DNA binding site [nucleotide binding]; other site
1091501001986	putative homodimer interface [polypeptide binding]; other site
1091501001987	ATP-dependent DNA ligase; Reviewed; Region: PRK09632
1091501001988	MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863
1091501001989	nucleotide binding site [chemical binding]; other site
1091501001990	DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777
1091501001991	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
1091501001992	active site
1091501001993	DNA binding site [nucleotide binding]
1091501001994	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
1091501001995	DNA binding site [nucleotide binding]
1091501001996	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
1091501001997	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1091501001998	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
1091501001999	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
1091501002000	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1091501002001	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
1091501002002	anti sigma factor interaction site; other site
1091501002003	regulatory phosphorylation site [posttranslational modification]; other site
1091501002004	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
1091501002005	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
1091501002006	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
1091501002007	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1091501002008	short chain dehydrogenase; Provisional; Region: PRK08251
1091501002009	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1091501002010	NAD(P) binding site [chemical binding]; other site
1091501002011	active site
1091501002012	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
1091501002013	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
1091501002014	active site
1091501002015	dimer interface [polypeptide binding]; other site
1091501002016	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
1091501002017	dimer interface [polypeptide binding]; other site
1091501002018	active site
1091501002019	Predicted esterase [General function prediction only]; Region: COG0627
1091501002020	Chorismate mutase type II; Region: CM_2; cl00693
1091501002021	Chorismate mutase type II; Region: CM_2; cl00693
1091501002022	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
1091501002023	Part of AAA domain; Region: AAA_19; pfam13245
1091501002024	Family description; Region: UvrD_C_2; pfam13538
1091501002025	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1091501002026	Peptidase family M23; Region: Peptidase_M23; pfam01551
1091501002027	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
1091501002028	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
1091501002029	CoA-ligase; Region: Ligase_CoA; pfam00549
1091501002030	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
1091501002031	CoA binding domain; Region: CoA_binding; smart00881
1091501002032	CoA-ligase; Region: Ligase_CoA; pfam00549
1091501002033	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
1091501002034	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1091501002035	potential frameshift: common BLAST hit: gi|224989351|ref|YP_002644038.1| integral membrane protein
1091501002036	Formyltransferase, catalytic core domain; Region: FMT_core; cl00395
1091501002037	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
1091501002038	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
1091501002039	purine monophosphate binding site [chemical binding]; other site
1091501002040	dimer interface [polypeptide binding]; other site
1091501002041	putative catalytic residues [active]
1091501002042	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
1091501002043	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
1091501002044	Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239
1091501002045	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
1091501002046	Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867
1091501002047	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
1091501002048	metal ion-dependent adhesion site (MIDAS); other site
1091501002049	PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873
1091501002050	homotetrameric interface [polypeptide binding]; other site
1091501002051	putative active site [active]
1091501002052	metal binding site [ion binding]; metal-binding site
1091501002053	Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259
1091501002054	Thermus thermophilus CsoR, a Cu(I)-sensing transcriptional regulator, and related domains; this domain family was previously known as part of DUF156; Region: TthCsoR-like_DUF156; cd10151
1091501002055	putative homodimer interface [polypeptide binding]; other site
1091501002056	putative homotetramer interface [polypeptide binding]; other site
1091501002057	allosteric switch controlling residues; other site
1091501002058	putative metal binding site [ion binding]; other site
1091501002059	putative homodimer-homodimer interface [polypeptide binding]; other site
1091501002060	Protein of unknown function (DUF1490); Region: DUF1490; pfam07371
1091501002061	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
1091501002062	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1091501002063	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1091501002064	enoyl-CoA hydratase; Provisional; Region: PRK07827
1091501002065	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1091501002066	substrate binding site [chemical binding]; other site
1091501002067	oxyanion hole (OAH) forming residues; other site
1091501002068	trimer interface [polypeptide binding]; other site
1091501002069	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1091501002070	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
1091501002071	active site
1091501002072	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
1091501002073	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1091501002074	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1091501002075	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1091501002076	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1091501002077	carboxyltransferase (CT) interaction site; other site
1091501002078	biotinylation site [posttranslational modification]; other site
1091501002079	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
1091501002080	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1091501002081	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1091501002082	active site
1091501002083	PE family; Region: PE; pfam00934
1091501002084	Uncharacterized conserved protein [Function unknown]; Region: COG3391
1091501002085	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
1091501002086	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
1091501002087	PE family; Region: PE; pfam00934
1091501002088	Uncharacterized conserved protein [Function unknown]; Region: COG3391
1091501002089	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
1091501002090	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
1091501002091	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
1091501002092	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1091501002093	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1091501002094	active site
1091501002095	phosphorylation site [posttranslational modification]
1091501002096	intermolecular recognition site; other site
1091501002097	dimerization interface [polypeptide binding]; other site
1091501002098	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1091501002099	DNA binding site [nucleotide binding]
1091501002100	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
1091501002101	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1091501002102	dimerization interface [polypeptide binding]; other site
1091501002103	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1091501002104	dimer interface [polypeptide binding]; other site
1091501002105	phosphorylation site [posttranslational modification]
1091501002106	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1091501002107	ATP binding site [chemical binding]; other site
1091501002108	Mg2+ binding site [ion binding]; other site
1091501002109	G-X-G motif; other site
1091501002110	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
1091501002111	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1091501002112	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
1091501002113	MPT binding site; other site
1091501002114	trimer interface [polypeptide binding]; other site
1091501002115	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
1091501002116	Large-conductance mechanosensitive channel, MscL; Region: MscL; pfam01741
1091501002117	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1091501002118	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1091501002119	Walker A/P-loop; other site
1091501002120	ATP binding site [chemical binding]; other site
1091501002121	Q-loop/lid; other site
1091501002122	ABC transporter signature motif; other site
1091501002123	Walker B; other site
1091501002124	D-loop; other site
1091501002125	H-loop/switch region; other site
1091501002126	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
1091501002127	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1091501002128	FtsX-like permease family; Region: FtsX; pfam02687
1091501002129	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1091501002130	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1091501002131	FtsX-like permease family; Region: FtsX; pfam02687
1091501002132	Predicted secreted hydrolase [General function prediction only]; Region: COG5621
1091501002133	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1091501002134	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1091501002135	substrate binding pocket [chemical binding]; other site
1091501002136	chain length determination region; other site
1091501002137	substrate-Mg2+ binding site; other site
1091501002138	catalytic residues [active]
1091501002139	aspartate-rich region 1; other site
1091501002140	active site lid residues [active]
1091501002141	aspartate-rich region 2; other site
1091501002142	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
1091501002143	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2331
1091501002144	5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212
1091501002145	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
1091501002146	UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210
1091501002147	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
1091501002148	active site
1091501002149	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
1091501002150	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
1091501002151	dimer interface [polypeptide binding]; other site
1091501002152	putative functional site; other site
1091501002153	putative MPT binding site; other site
1091501002154	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1091501002155	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1091501002156	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1091501002157	S-adenosylmethionine binding site [chemical binding]; other site
1091501002158	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1091501002159	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1091501002160	ligand binding site [chemical binding]; other site
1091501002161	flexible hinge region; other site
1091501002162	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1091501002163	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1091501002164	Coenzyme A binding pocket [chemical binding]; other site
1091501002165	Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145
1091501002166	potential frameshift: common BLAST hit: gi|340626013|ref|YP_004744465.1| putative arginine deiminase
1091501002167	Predicted methyltransferases [General function prediction only]; Region: COG0313
1091501002168	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
1091501002169	putative SAM binding site [chemical binding]; other site
1091501002170	putative homodimer interface [polypeptide binding]; other site
1091501002171	aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553
1091501002172	aminodeoxychorismate synthase, component I, clade 2; Region: PabB-clade2; TIGR01824
1091501002173	methionyl-tRNA synthetase; Reviewed; Region: PRK11893
1091501002174	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
1091501002175	active site
1091501002176	HIGH motif; other site
1091501002177	KMSKS motif; other site
1091501002178	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
1091501002179	tRNA binding surface [nucleotide binding]; other site
1091501002180	anticodon binding site; other site
1091501002181	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
1091501002182	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
1091501002183	active site
1091501002184	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583
1091501002185	Domain of unknown function (DUF348); Region: DUF348; pfam03990
1091501002186	Domain of unknown function (DUF348); Region: DUF348; pfam03990
1091501002187	G5 domain; Region: G5; pfam07501
1091501002188	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
1091501002189	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
1091501002190	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
1091501002191	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188
1091501002192	Increased loss of mitochondrial DNA protein 1; Region: Ilm1; pfam10311
1091501002193	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
1091501002194	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768
1091501002195	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1091501002196	acyl-activating enzyme (AAE) consensus motif; other site
1091501002197	AMP binding site [chemical binding]; other site
1091501002198	active site
1091501002199	CoA binding site [chemical binding]; other site
1091501002200	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
1091501002201	putative active site [active]
1091501002202	catalytic residue [active]
1091501002203	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
1091501002204	ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731
1091501002205	5S rRNA interface [nucleotide binding]; other site
1091501002206	CTC domain interface [polypeptide binding]; other site
1091501002207	L16 interface [polypeptide binding]; other site
1091501002208	Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738
1091501002209	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
1091501002210	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092
1091501002211	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1091501002212	active site
1091501002213	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352
1091501002214	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
1091501002215	Substrate binding site; other site
1091501002216	Mg++ binding site; other site
1091501002217	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
1091501002218	active site
1091501002219	substrate binding site [chemical binding]; other site
1091501002220	CoA binding site [chemical binding]; other site
1091501002221	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1091501002222	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1091501002223	potential frameshift: common BLAST hit: gi|253799950|ref|YP_003032951.1| transcription-repair coupling factor mfd
1091501002224	potential frameshift: common BLAST hit: gi|253799950|ref|YP_003032951.1| transcription-repair coupling factor mfd
1091501002225	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334
1091501002226	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
1091501002227	homodimer interface [polypeptide binding]; other site
1091501002228	metal binding site [ion binding]; metal-binding site
1091501002229	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941
1091501002230	Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951
1091501002231	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1091501002232	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1091501002233	enolase; Provisional; Region: eno; PRK00077
1091501002234	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
1091501002235	dimer interface [polypeptide binding]; other site
1091501002236	metal binding site [ion binding]; metal-binding site
1091501002237	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
1091501002238	substrate binding pocket [chemical binding]; other site
1091501002239	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
1091501002240	Septum formation initiator; Region: DivIC; pfam04977
1091501002241	exopolyphosphatase; Region: exo_poly_only; TIGR03706
1091501002242	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
1091501002243	DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529
1091501002244	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1091501002245	active site
1091501002246	phosphorylation site [posttranslational modification]
1091501002247	intermolecular recognition site; other site
1091501002248	dimerization interface [polypeptide binding]; other site
1091501002249	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1091501002250	DNA binding site [nucleotide binding]
1091501002251	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
1091501002252	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
1091501002253	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
1091501002254	Ligand Binding Site [chemical binding]; other site
1091501002255	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1091501002256	dimer interface [polypeptide binding]; other site
1091501002257	phosphorylation site [posttranslational modification]
1091501002258	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1091501002259	ATP binding site [chemical binding]; other site
1091501002260	Mg2+ binding site [ion binding]; other site
1091501002261	G-X-G motif; other site
1091501002262	K+-transporting ATPase, KdpA; Region: kdpA; TIGR00680
1091501002263	potential frameshift: common BLAST hit: gi|253799939|ref|YP_003032940.1| potassium-transporting ATPase subunit B
1091501002264	potential frameshift: common BLAST hit: gi|339631093|ref|YP_004722735.1| potassium transporter ATPase subunit C
1091501002265	potential frameshift: common BLAST hit: gi|224989434|ref|YP_002644121.1| two component sensor histidine kinase
1091501002266	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1091501002267	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1091501002268	active site
1091501002269	phosphorylation site [posttranslational modification]
1091501002270	intermolecular recognition site; other site
1091501002271	dimerization interface [polypeptide binding]; other site
1091501002272	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1091501002273	DNA binding site [nucleotide binding]
1091501002274	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
1091501002275	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
1091501002276	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
1091501002277	potential frameshift: common BLAST hit: gi|340628584|ref|YP_004747036.1| putative ESAT-6 like protein ESXV
1091501002278	WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930
1091501002279	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1091501002280	PPE family; Region: PPE; pfam00823
1091501002281	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
1091501002282	PE family; Region: PE; pfam00934
1091501002283	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
1091501002284	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1091501002285	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
1091501002286	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
1091501002287	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
1091501002288	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1091501002289	Predicted transcriptional regulator [Transcription]; Region: COG5340
1091501002290	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
1091501002291	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1091501002292	MULE transposase domain; Region: MULE; pfam10551
1091501002293	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1091501002294	MarR family; Region: MarR_2; pfam12802
1091501002295	potential frameshift: common BLAST hit: gi|339631113|ref|YP_004722755.1| oxidoreductase
1091501002296	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
1091501002297	Helix-turn-helix domain; Region: HTH_17; pfam12728
1091501002298	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1091501002299	Domain of unknown function (DUF222); Region: DUF222; pfam02720
1091501002300	Uncharacterized conserved protein [Function unknown]; Region: COG3391
1091501002301	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
1091501002302	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119
1091501002303	dimer interface [polypeptide binding]; other site
1091501002304	acyl-activating enzyme (AAE) consensus motif; other site
1091501002305	putative active site [active]
1091501002306	AMP binding site [chemical binding]; other site
1091501002307	putative CoA binding site [chemical binding]; other site
1091501002308	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
1091501002309	Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604
1091501002310	hydrophobic ligand binding site; other site
1091501002311	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
1091501002312	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
1091501002313	putative active site [active]
1091501002314	putative dimer interface [polypeptide binding]; other site
1091501002315	Patatin-like phospholipase; Region: Patatin; pfam01734
1091501002316	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
1091501002317	nucleophile elbow; other site
1091501002318	hypothetical protein; Provisional; Region: PRK10279
1091501002319	Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228
1091501002320	active site
1091501002321	nucleophile elbow; other site
1091501002322	Cysteine dioxygenase type I; Region: CDO_I; pfam05995
1091501002323	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
1091501002324	active site residue [active]
1091501002325	PE family; Region: PE; pfam00934
1091501002326	PE family; Region: PE; pfam00934
1091501002327	Predicted membrane protein [Function unknown]; Region: COG4425
1091501002328	Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081
1091501002329	potential frameshift: common BLAST hit: gi|340626081|ref|YP_004744533.1| putative enoyl-CoA hydratase ECHA8
1091501002330	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
1091501002331	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1091501002332	substrate binding site [chemical binding]; other site
1091501002333	oxyanion hole (OAH) forming residues; other site
1091501002334	trimer interface [polypeptide binding]; other site
1091501002335	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
1091501002336	Predicted membrane protein [Function unknown]; Region: COG4760
1091501002337	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
1091501002338	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
1091501002339	acetyl-CoA acetyltransferase; Provisional; Region: PRK07851
1091501002340	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1091501002341	dimer interface [polypeptide binding]; other site
1091501002342	active site
1091501002343	SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836
1091501002344	active site
1091501002345	catalytic triad [active]
1091501002346	oxyanion hole [active]
1091501002347	potential frameshift: common BLAST hit: gi|253799888|ref|YP_003032889.1| lipase lipU
1091501002348	cystathionine beta-synthase; Region: cysta_beta; TIGR01137
1091501002349	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1091501002350	dimer interface [polypeptide binding]; other site
1091501002351	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1091501002352	catalytic residue [active]
1091501002353	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream.   The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609
1091501002354	RDD family; Region: RDD; pfam06271
1091501002355	potential frameshift: common BLAST hit: gi|340626090|ref|YP_004744542.1| putative cystathionine gamma-synthase METB
1091501002356	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
1091501002357	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
1091501002358	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
1091501002359	Domain of unknown function (DUF4307); Region: DUF4307; pfam14155
1091501002360	potential frameshift: common BLAST hit: gi|378770845|ref|YP_005170578.1| Mycothiol S-conjugate amidase
1091501002361	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
1091501002362	mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446
1091501002363	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
1091501002364	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
1091501002365	catalytic residues [active]
1091501002366	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183
1091501002367	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
1091501002368	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
1091501002369	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
1091501002370	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
1091501002371	catalytic residue [active]
1091501002372	putative FPP diphosphate  binding site; other site
1091501002373	putative FPP binding hydrophobic cleft; other site
1091501002374	dimer interface [polypeptide binding]; other site
1091501002375	putative IPP diphosphate binding site; other site
1091501002376	PE family; Region: PE; pfam00934
1091501002377	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
1091501002378	putative IPP diphosphate binding site; other site
1091501002379	Glycosyl hydrolase family 12; Region: Glyco_hydro_12; pfam01670
1091501002380	PE family; Region: PE; pfam00934
1091501002381	pantothenate kinase; Provisional; Region: PRK05439
1091501002382	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
1091501002383	ATP-binding site [chemical binding]; other site
1091501002384	CoA-binding site [chemical binding]; other site
1091501002385	Mg2+-binding site [ion binding]; other site
1091501002386	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
1091501002387	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
1091501002388	dimer interface [polypeptide binding]; other site
1091501002389	active site
1091501002390	glycine-pyridoxal phosphate binding site [chemical binding]; other site
1091501002391	folate binding site [chemical binding]; other site
1091501002392	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
1091501002393	dinuclear metal binding motif [ion binding]; other site
1091501002394	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
1091501002395	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
1091501002396	putative active site [active]
1091501002397	PhoH-like protein; Region: PhoH; pfam02562
1091501002398	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
1091501002399	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
1091501002400	NodB motif; other site
1091501002401	active site
1091501002402	catalytic site [active]
1091501002403	metal binding site [ion binding]; metal-binding site
1091501002404	fumarate hydratase; Reviewed; Region: fumC; PRK00485
1091501002405	Class II fumarases; Region: Fumarase_classII; cd01362
1091501002406	active site
1091501002407	tetramer interface [polypeptide binding]; other site
1091501002408	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
1091501002409	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
1091501002410	putative active site [active]
1091501002411	Protein of unknown function (DUF4245); Region: DUF4245; pfam14030
1091501002412	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1091501002413	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1091501002414	Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337
1091501002415	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
1091501002416	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1091501002417	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1091501002418	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1091501002419	3beta-hydroxysteroid dehydrogenases (3b-HSD)-like, extended (e) SDRs; Region: 3b-HSD-like_SDR_e; cd05241
1091501002420	3-beta hydroxysteroid dehydrogenase/isomerase family; Region: 3Beta_HSD; pfam01073
1091501002421	putative NAD(P) binding site [chemical binding]; other site
1091501002422	active site
1091501002423	putative substrate binding site [chemical binding]; other site
1091501002424	exodeoxyribonuclease VII, small subunit; Region: xseB; TIGR01280
1091501002425	Exonuclease VII, large subunit [DNA replication, recombination, and repair]; Region: XseA; COG1570
1091501002426	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
1091501002427	generic binding surface II; other site
1091501002428	generic binding surface I; other site
1091501002429	potential frameshift: common BLAST hit: gi|340626124|ref|YP_004744576.1| putative LYTB-like protein LYTB2
1091501002430	GTP-binding protein YchF; Reviewed; Region: PRK09601
1091501002431	YchF GTPase; Region: YchF; cd01900
1091501002432	G1 box; other site
1091501002433	GTP/Mg2+ binding site [chemical binding]; other site
1091501002434	Switch I region; other site
1091501002435	G2 box; other site
1091501002436	Switch II region; other site
1091501002437	G3 box; other site
1091501002438	G4 box; other site
1091501002439	G5 box; other site
1091501002440	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
1091501002441	Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957
1091501002442	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
1091501002443	putative active site [active]
1091501002444	Uncharacterized conserved protein [Function unknown]; Region: COG1359
1091501002445	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
1091501002446	cyclase homology domain; Region: CHD; cd07302
1091501002447	nucleotidyl binding site; other site
1091501002448	metal binding site [ion binding]; metal-binding site
1091501002449	dimer interface [polypeptide binding]; other site
1091501002450	potential frameshift: common BLAST hit: gi|340626134|ref|YP_004744586.1| putative glucose-6-phosphate 1-dehydrogenase ZWF1
1091501002451	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1091501002452	6-phosphogluconate dehydrogenase (decarboxylating); Region: gnd_rel; TIGR00872
1091501002453	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1091501002454	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1091501002455	pyruvate phosphate dikinase; Provisional; Region: PRK05878
1091501002456	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
1091501002457	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700
1091501002458	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1091501002459	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1091501002460	non-specific DNA binding site [nucleotide binding]; other site
1091501002461	salt bridge; other site
1091501002462	sequence-specific DNA binding site [nucleotide binding]; other site
1091501002463	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
1091501002464	Domain of unknown function (DUF955); Region: DUF955; pfam06114
1091501002465	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
1091501002466	Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079
1091501002467	citrate synthase; Provisional; Region: PRK14033
1091501002468	Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416
1091501002469	oxalacetate binding site [chemical binding]; other site
1091501002470	citrylCoA binding site [chemical binding]; other site
1091501002471	coenzyme A binding site [chemical binding]; other site
1091501002472	catalytic triad [active]
1091501002473	Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077
1091501002474	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
1091501002475	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
1091501002476	substrate binding site [chemical binding]; other site
1091501002477	methionine synthase; Provisional; Region: PRK01207
1091501002478	THF binding site; other site
1091501002479	zinc-binding site [ion binding]; other site
1091501002480	potential frameshift: common BLAST hit: gi|224989540|ref|YP_002644227.1| PPE family protein
1091501002481	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
1091501002482	active site
1091501002483	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
1091501002484	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1091501002485	substrate binding site [chemical binding]; other site
1091501002486	oxyanion hole (OAH) forming residues; other site
1091501002487	enoyl-CoA hydratase; Provisional; Region: PRK06494
1091501002488	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
1091501002489	CAAX protease self-immunity; Region: Abi; pfam02517
1091501002490	enoyl-CoA hydratase; Provisional; Region: PRK06688
1091501002491	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762
1091501002492	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1091501002493	trimer interface [polypeptide binding]; other site
1091501002494	potential frameshift: common BLAST hit: gi|340626157|ref|YP_004744609.1| putative enoyl-CoA hydratase ECHA10
1091501002495	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
1091501002496	CoA-transferase family III; Region: CoA_transf_3; pfam02515
1091501002497	17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371
1091501002498	NAD binding site [chemical binding]; other site
1091501002499	homodimer interface [polypeptide binding]; other site
1091501002500	homotetramer interface [polypeptide binding]; other site
1091501002501	active site
1091501002502	MMPL family; Region: MMPL; pfam03176
1091501002503	MMPL family; Region: MMPL; pfam03176
1091501002504	Domain of unknown function (DUF222); Region: DUF222; pfam02720
1091501002505	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1091501002506	active site
1091501002507	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
1091501002508	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1091501002509	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
1091501002510	NAD-dependent deacetylase; Provisional; Region: PRK00481
1091501002511	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
1091501002512	NAD+ binding site [chemical binding]; other site
1091501002513	substrate binding site [chemical binding]; other site
1091501002514	Zn binding site [ion binding]; other site
1091501002515	Predicted transcriptional regulators [Transcription]; Region: COG1725
1091501002516	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1091501002517	DNA-binding site [nucleotide binding]; DNA binding site
1091501002518	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
1091501002519	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
1091501002520	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797
1091501002521	PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618
1091501002522	uncharacterized HhH-GPD family protein; Region: TIGR03252
1091501002523	minor groove reading motif; other site
1091501002524	helix-hairpin-helix signature motif; other site
1091501002525	mannosyltransferase; Provisional; Region: pimE; PRK13375
1091501002526	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488
1091501002527	aromatic arch; other site
1091501002528	DCoH dimer interaction site [polypeptide binding]; other site
1091501002529	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
1091501002530	DCoH tetramer interaction site [polypeptide binding]; other site
1091501002531	substrate binding site [chemical binding]; other site
1091501002532	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
1091501002533	active site
1091501002534	8-oxo-dGMP binding site [chemical binding]; other site
1091501002535	nudix motif; other site
1091501002536	metal binding site [ion binding]; metal-binding site
1091501002537	potential frameshift: common BLAST hit: gi|339631227|ref|YP_004722869.1| nitrate reductase subunit alpha
1091501002538	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
1091501002539	nitrate reductase molybdenum cofactor assembly chaperone; Region: narJ; TIGR00684
1091501002540	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665
1091501002541	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
1091501002542	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
1091501002543	G1 box; other site
1091501002544	putative GEF interaction site [polypeptide binding]; other site
1091501002545	GTP/Mg2+ binding site [chemical binding]; other site
1091501002546	Switch I region; other site
1091501002547	G2 box; other site
1091501002548	G3 box; other site
1091501002549	Switch II region; other site
1091501002550	G4 box; other site
1091501002551	G5 box; other site
1091501002552	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
1091501002553	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
1091501002554	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1091501002555	The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501
1091501002556	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
1091501002557	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1091501002558	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1091501002559	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1091501002560	PPE family; Region: PPE; pfam00823
1091501002561	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
1091501002562	PE family; Region: PE; pfam00934
1091501002563	N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D- glucopyranoside deacetylase; Region: mycothiol_MshB; TIGR03445
1091501002564	PE family; Region: PE; pfam00934
1091501002565	potential frameshift: common BLAST hit: gi|340626187|ref|YP_004744639.1| putative F420 biosynthesis protein FBIC
1091501002566	potential frameshift: common BLAST hit: gi|340626189|ref|YP_004744641.1| putative NADPH dependent 2,4-DIenoyl-COA reductase FADH
1091501002567	Predicted transcriptional regulators [Transcription]; Region: COG1695
1091501002568	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
1091501002569	Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400
1091501002570	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
1091501002571	4Fe-4S binding domain; Region: Fer4; pfam00037
1091501002572	potential frameshift: common BLAST hit: gi|253799778|ref|YP_003032779.1| N-succinyldiaminopimelate aminotransferase
1091501002573	potential frameshift: common BLAST hit: gi|253799778|ref|YP_003032779.1| N-succinyldiaminopimelate aminotransferase
1091501002574	potential frameshift: common BLAST hit: gi|148660968|ref|YP_001282491.1| polyketide beta-ketoacyl synthase Pks3
1091501002575	potential frameshift: common BLAST hit: gi|339631248|ref|YP_004722890.1| polyketide beta-ketoacyl synthase
1091501002576	potential frameshift: common BLAST hit: gi|340626196|ref|YP_004744648.1| putative polyketide synthase associated protein PAPA3
1091501002577	potential frameshift: common BLAST hit: gi|339631250|ref|YP_004722892.1| transporter
1091501002578	PE-PPE domain; Region: PE-PPE; pfam08237
1091501002579	acyl-CoA synthetase; Validated; Region: PRK05850
1091501002580	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
1091501002581	acyl-activating enzyme (AAE) consensus motif; other site
1091501002582	active site
1091501002583	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
1091501002584	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
1091501002585	Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123
1091501002586	delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236
1091501002587	Glutamate binding site [chemical binding]; other site
1091501002588	NAD binding site [chemical binding]; other site
1091501002589	catalytic residues [active]
1091501002590	Proline dehydrogenase; Region: Pro_dh; pfam01619
1091501002591	RNA polymerase sigma factor SigI; Provisional; Region: sigI; PRK09635
1091501002592	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1091501002593	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1091501002594	DNA binding residues [nucleotide binding]
1091501002595	haloalkane dehalogenase; Provisional; Region: PRK03204
1091501002596	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
1091501002597	catalytic site [active]
1091501002598	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1091501002599	Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342
1091501002600	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1091501002601	PGAP1-like protein; Region: PGAP1; pfam07819
1091501002602	acyl-CoA synthetase; Validated; Region: PRK07787
1091501002603	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1091501002604	acyl-activating enzyme (AAE) consensus motif; other site
1091501002605	AMP binding site [chemical binding]; other site
1091501002606	active site
1091501002607	CoA binding site [chemical binding]; other site
1091501002608	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
1091501002609	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
1091501002610	PE family; Region: PE; pfam00934
1091501002611	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1091501002612	PPE family; Region: PPE; pfam00823
1091501002613	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
1091501002614	WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930
1091501002615	Proteins of 100 residues with WXG; Region: WXG100; pfam06013
1091501002616	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1091501002617	MULE transposase domain; Region: MULE; pfam10551
1091501002618	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1091501002619	putative substrate translocation pore; other site
1091501002620	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535
1091501002621	Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649
1091501002622	putative trimer interface [polypeptide binding]; other site
1091501002623	putative CoA binding site [chemical binding]; other site
1091501002624	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007
1091501002625	M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647
1091501002626	metal binding site [ion binding]; metal-binding site
1091501002627	putative dimer interface [polypeptide binding]; other site
1091501002628	TIGR00730 family protein; Region: TIGR00730
1091501002629	potential frameshift: common BLAST hit: gi|340626219|ref|YP_004744671.1| putative fatty-acid-CoA ligase FADD6
1091501002630	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
1091501002631	dihydropteroate synthase; Region: DHPS; TIGR01496
1091501002632	substrate binding pocket [chemical binding]; other site
1091501002633	dimer interface [polypeptide binding]; other site
1091501002634	inhibitor binding site; inhibition site
1091501002635	putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915
1091501002636	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1091501002637	DivIVA domain; Region: DivI1A_domain; TIGR03544
1091501002638	Methyladenine glycosylase; Region: Adenine_glyco; cl01059
1091501002639	Protein of unknown function (DUF3117); Region: DUF3117; pfam11314
1091501002640	glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149
1091501002641	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1091501002642	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844
1091501002643	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
1091501002644	ligand binding site; other site
1091501002645	oligomer interface; other site
1091501002646	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
1091501002647	dimer interface [polypeptide binding]; other site
1091501002648	N-terminal domain interface [polypeptide binding]; other site
1091501002649	sulfate 1 binding site; other site
1091501002650	PE family; Region: PE; pfam00934
1091501002651	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939
1091501002652	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
1091501002653	Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559
1091501002654	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1091501002655	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1091501002656	Walker A/P-loop; other site
1091501002657	ATP binding site [chemical binding]; other site
1091501002658	Q-loop/lid; other site
1091501002659	ABC transporter signature motif; other site
1091501002660	Walker B; other site
1091501002661	D-loop; other site
1091501002662	H-loop/switch region; other site
1091501002663	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
1091501002664	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
1091501002665	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1091501002666	S-adenosylmethionine binding site [chemical binding]; other site
1091501002667	RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647
1091501002668	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1091501002669	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1091501002670	DNA binding residues [nucleotide binding]
1091501002671	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
1091501002672	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1091501002673	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1091501002674	protein binding site [polypeptide binding]; other site
1091501002675	sec-independent translocase; Provisional; Region: PRK03100
1091501002676	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
1091501002677	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1091501002678	active site
1091501002679	motif I; other site
1091501002680	motif II; other site
1091501002681	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1091501002682	potential frameshift: common BLAST hit: gi|224989630|ref|YP_002644317.1| transmembrane protein
1091501002683	Uncharacterized conserved protein [Function unknown]; Region: COG3402
1091501002684	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
1091501002685	potential frameshift: common BLAST hit: gi|340626242|ref|YP_004744694.1| putative MRP-like protein MRP
1091501002686	Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951
1091501002687	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1091501002688	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1091501002689	catalytic residue [active]
1091501002690	Predicted membrane protein [Function unknown]; Region: COG4420
1091501002691	Domain of unknown function (DUF4190); Region: DUF4190; pfam13828
1091501002692	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1091501002693	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1091501002694	potential frameshift: common BLAST hit: gi|340626249|ref|YP_004744701.1| putative sugar-transport integral membrane protein ABC transporter
1091501002695	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1091501002696	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1091501002697	dimer interface [polypeptide binding]; other site
1091501002698	conserved gate region; other site
1091501002699	ABC-ATPase subunit interface; other site
1091501002700	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
1091501002701	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1091501002702	Walker A/P-loop; other site
1091501002703	ATP binding site [chemical binding]; other site
1091501002704	Q-loop/lid; other site
1091501002705	ABC transporter signature motif; other site
1091501002706	Walker B; other site
1091501002707	D-loop; other site
1091501002708	H-loop/switch region; other site
1091501002709	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
1091501002710	Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830
1091501002711	oligomer interface [polypeptide binding]; other site
1091501002712	metal binding site [ion binding]; metal-binding site
1091501002713	metal binding site [ion binding]; metal-binding site
1091501002714	putative Cl binding site [ion binding]; other site
1091501002715	basic sphincter; other site
1091501002716	hydrophobic gate; other site
1091501002717	periplasmic entrance; other site
1091501002718	malate dehydrogenase; Provisional; Region: PRK05442
1091501002719	Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338
1091501002720	NAD(P) binding site [chemical binding]; other site
1091501002721	dimer interface [polypeptide binding]; other site
1091501002722	malate binding site [chemical binding]; other site
1091501002723	Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028
1091501002724	potential frameshift: common BLAST hit: gi|148822460|ref|YP_001287214.1| PE-PGRS family protein
1091501002725	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
1091501002726	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
1091501002727	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1091501002728	NAD(P) binding site [chemical binding]; other site
1091501002729	active site
1091501002730	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
1091501002731	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161
1091501002732	alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270
1091501002733	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1091501002734	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
1091501002735	TPP-binding site [chemical binding]; other site
1091501002736	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
1091501002737	dimer interface [polypeptide binding]; other site
1091501002738	PYR/PP interface [polypeptide binding]; other site
1091501002739	TPP binding site [chemical binding]; other site
1091501002740	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1091501002741	potential frameshift: common BLAST hit: gi|339631317|ref|YP_004722959.1| multidrug ABC transporter
1091501002742	LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041
1091501002743	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
1091501002744	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1091501002745	ATP binding site [chemical binding]; other site
1091501002746	Mg++ binding site [ion binding]; other site
1091501002747	motif III; other site
1091501002748	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1091501002749	nucleotide binding region [chemical binding]; other site
1091501002750	ATP-binding site [chemical binding]; other site
1091501002751	RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499
1091501002752	putative RNA binding site [nucleotide binding]; other site
1091501002753	Acyltransferase family; Region: Acyl_transf_3; pfam01757
1091501002754	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1091501002755	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1091501002756	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1091501002757	FAD binding domain; Region: FAD_binding_4; pfam01565
1091501002758	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1091501002759	H+ Antiporter protein; Region: 2A0121; TIGR00900
1091501002760	putative substrate translocation pore; other site
1091501002761	Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031
1091501002762	Fe-S cluster binding site [ion binding]; other site
1091501002763	DNA binding site [nucleotide binding]
1091501002764	active site
1091501002765	hypothetical protein; Validated; Region: PRK05868
1091501002766	hypothetical protein; Provisional; Region: PRK07236
1091501002767	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1091501002768	Domain of unknown function (DUF385); Region: DUF385; pfam04075
1091501002769	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
1091501002770	HIT family signature motif; other site
1091501002771	catalytic residue [active]
1091501002772	amidase; Provisional; Region: PRK12470
1091501002773	Amidase; Region: Amidase; pfam01425
1091501002774	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
1091501002775	cyclase homology domain; Region: CHD; cd07302
1091501002776	nucleotidyl binding site; other site
1091501002777	metal binding site [ion binding]; metal-binding site
1091501002778	dimer interface [polypeptide binding]; other site
1091501002779	potential frameshift: common BLAST hit: gi|253799689|ref|YP_003032690.1| Ser/Thr protein kinase
1091501002780	DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629
1091501002781	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486
1091501002782	DNA binding site [nucleotide binding]
1091501002783	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1091501002784	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
1091501002785	phosphopeptide binding site; other site
1091501002786	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
1091501002787	putative active site [active]
1091501002788	Domain of unknown function (DUF4189); Region: DUF4189; pfam13827
1091501002789	Protein of unknown function (DUF1396); Region: DUF1396; pfam07161
1091501002790	Protein of unknown function (DUF732); Region: DUF732; pfam05305
1091501002791	potential frameshift: common BLAST hit: gi|339631340|ref|YP_004722982.1| multidrug ABC transporter ATP-binding protein
1091501002792	potential frameshift: common BLAST hit: gi|339631340|ref|YP_004722982.1| multidrug ABC transporter ATP-binding protein
1091501002793	potential frameshift: common BLAST hit: gi|253799682|ref|YP_003032683.1| drugs-transport transmembrane ATP-binding protein ABC transporter
1091501002794	Protein of unknown function (DUF3558); Region: DUF3558; pfam12079
1091501002795	Protein of unknown function (DUF3558); Region: DUF3558; pfam12079
1091501002796	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1091501002797	catalytic core [active]
1091501002798	GMC oxidoreductase; Region: GMC_oxred_N; pfam00732
1091501002799	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1091501002800	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1091501002801	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1091501002802	The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501
1091501002803	potential frameshift: common BLAST hit: gi|339631349|ref|YP_004722991.1| peptide ABC transporter ATP-binding protein
1091501002804	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1091501002805	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1091501002806	dimer interface [polypeptide binding]; other site
1091501002807	conserved gate region; other site
1091501002808	putative PBP binding loops; other site
1091501002809	ABC-ATPase subunit interface; other site
1091501002810	oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471
1091501002811	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1091501002812	dimer interface [polypeptide binding]; other site
1091501002813	conserved gate region; other site
1091501002814	putative PBP binding loops; other site
1091501002815	ABC-ATPase subunit interface; other site
1091501002816	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379
1091501002817	active site clefts [active]
1091501002818	zinc binding site [ion binding]; other site
1091501002819	dimer interface [polypeptide binding]; other site
1091501002820	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
1091501002821	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
1091501002822	Active Sites [active]
1091501002823	bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506
1091501002824	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
1091501002825	CysD dimerization site [polypeptide binding]; other site
1091501002826	G1 box; other site
1091501002827	putative GEF interaction site [polypeptide binding]; other site
1091501002828	GTP/Mg2+ binding site [chemical binding]; other site
1091501002829	Switch I region; other site
1091501002830	G2 box; other site
1091501002831	G3 box; other site
1091501002832	Switch II region; other site
1091501002833	G4 box; other site
1091501002834	G5 box; other site
1091501002835	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
1091501002836	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
1091501002837	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1091501002838	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
1091501002839	Walker A/P-loop; other site
1091501002840	ligand-binding site [chemical binding]; other site
1091501002841	ATP binding site [chemical binding]; other site
1091501002842	Rrf2 family protein; Region: rrf2_super; TIGR00738
1091501002843	Transcriptional regulator; Region: Rrf2; pfam02082
1091501002844	Predicted membrane protein [Function unknown]; Region: COG4325
1091501002845	Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011
1091501002846	Protein of unknown function (DUF732); Region: DUF732; pfam05305
1091501002847	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
1091501002848	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
1091501002849	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
1091501002850	active site
1091501002851	HIGH motif; other site
1091501002852	KMSK motif region; other site
1091501002853	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
1091501002854	tRNA binding surface [nucleotide binding]; other site
1091501002855	anticodon binding site; other site
1091501002856	potential frameshift: common BLAST hit: gi|340626309|ref|YP_004744761.1| putative diaminopimelate decarboxylase LYSA
1091501002857	homoserine dehydrogenase; Provisional; Region: PRK06349
1091501002858	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
1091501002859	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
1091501002860	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
1091501002861	potential frameshift: common BLAST hit: gi|340626311|ref|YP_004744763.1| putative threonine synthase THRC
1091501002862	Homoserine kinase [Amino acid transport and metabolism]; Region: ThrB; COG0083
1091501002863	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
1091501002864	transcription termination factor Rho; Provisional; Region: PRK12608
1091501002865	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1091501002866	RNA binding site [nucleotide binding]; other site
1091501002867	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
1091501002868	multimer interface [polypeptide binding]; other site
1091501002869	Walker A motif; other site
1091501002870	ATP binding site [chemical binding]; other site
1091501002871	Walker B motif; other site
1091501002872	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
1091501002873	peptide chain release factor 1; Region: prfA; TIGR00019
1091501002874	This domain is found in peptide chain release factors; Region: PCRF; smart00937
1091501002875	RF-1 domain; Region: RF-1; pfam00472
1091501002876	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
1091501002877	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1091501002878	S-adenosylmethionine binding site [chemical binding]; other site
1091501002879	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
1091501002880	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
1091501002881	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
1091501002882	Mg++ binding site [ion binding]; other site
1091501002883	putative catalytic motif [active]
1091501002884	substrate binding site [chemical binding]; other site
1091501002885	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
1091501002886	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
1091501002887	F0F1 ATP synthase subunit C; Validated; Region: PRK05880
1091501002888	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
1091501002889	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
1091501002890	F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210
1091501002891	potential frameshift: common BLAST hit: gi|339631376|ref|YP_004723018.1| ATP synthase subunit alpha
1091501002892	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
1091501002893	core domain interface [polypeptide binding]; other site
1091501002894	delta subunit interface [polypeptide binding]; other site
1091501002895	epsilon subunit interface [polypeptide binding]; other site
1091501002896	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
1091501002897	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1091501002898	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
1091501002899	alpha subunit interaction interface [polypeptide binding]; other site
1091501002900	Walker A motif; other site
1091501002901	ATP binding site [chemical binding]; other site
1091501002902	Walker B motif; other site
1091501002903	inhibitor binding site; inhibition site
1091501002904	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1091501002905	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
1091501002906	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
1091501002907	gamma subunit interface [polypeptide binding]; other site
1091501002908	epsilon subunit interface [polypeptide binding]; other site
1091501002909	LBP interface [polypeptide binding]; other site
1091501002910	Protein of unknown function (DUF2550); Region: DUF2550; pfam10739
1091501002911	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
1091501002912	Transposase; Region: DDE_Tnp_ISL3; pfam01610
1091501002913	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
1091501002914	Transposase; Region: DDE_Tnp_ISL3; pfam01610
1091501002915	potential frameshift: common BLAST hit: gi|253799640|ref|YP_003032641.1| ATP:cob(I)alamin adenosyltransferase
1091501002916	potential frameshift: common BLAST hit: gi|340626330|ref|YP_004744782.1| putative UDP-N-acetylglucosamine 1-carboxyvinyltransferase MURA
1091501002917	potential frameshift: common BLAST hit: gi|340626330|ref|YP_004744782.1| putative UDP-N-acetylglucosamine 1-carboxyvinyltransferase MURA
1091501002918	methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901
1091501002919	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
1091501002920	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1091501002921	DNA binding site [nucleotide binding]
1091501002922	active site
1091501002923	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169
1091501002924	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
1091501002925	AlkA N-terminal domain; Region: AlkA_N; pfam06029
1091501002926	3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122
1091501002927	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1091501002928	minor groove reading motif; other site
1091501002929	helix-hairpin-helix signature motif; other site
1091501002930	substrate binding pocket [chemical binding]; other site
1091501002931	active site
1091501002932	potential frameshift: common BLAST hit: gi|224989722|ref|YP_002644409.1| adenylate cyclase
1091501002933	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1091501002934	dimerization interface [polypeptide binding]; other site
1091501002935	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
1091501002936	cyclase homology domain; Region: CHD; cd07302
1091501002937	nucleotidyl binding site; other site
1091501002938	metal binding site [ion binding]; metal-binding site
1091501002939	dimer interface [polypeptide binding]; other site
1091501002940	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
1091501002941	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1091501002942	dimerization interface [polypeptide binding]; other site
1091501002943	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
1091501002944	cyclase homology domain; Region: CHD; cd07302
1091501002945	nucleotidyl binding site; other site
1091501002946	metal binding site [ion binding]; metal-binding site
1091501002947	dimer interface [polypeptide binding]; other site
1091501002948	Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637
1091501002949	hypothetical protein; Provisional; Region: PRK03298
1091501002950	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1091501002951	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
1091501002952	dimer interface [polypeptide binding]; other site
1091501002953	substrate binding site [chemical binding]; other site
1091501002954	metal binding site [ion binding]; metal-binding site
1091501002955	ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822
1091501002956	putative acyltransferase; Provisional; Region: PRK05790
1091501002957	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1091501002958	dimer interface [polypeptide binding]; other site
1091501002959	active site
1091501002960	potential frameshift: common BLAST hit: gi|340626341|ref|YP_004744793.1| putative thioredoxin
1091501002961	PE family; Region: PE; pfam00934
1091501002962	glycogen branching enzyme; Provisional; Region: PRK05402
1091501002963	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
1091501002964	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
1091501002965	active site
1091501002966	catalytic site [active]
1091501002967	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
1091501002968	Domain of unknown function (DUF3416); Region: DUF3416; pfam11896
1091501002969	Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344
1091501002970	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
1091501002971	active site
1091501002972	homodimer interface [polypeptide binding]; other site
1091501002973	catalytic site [active]
1091501002974	acceptor binding site [chemical binding]; other site
1091501002975	This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299
1091501002976	putative homodimer interface [polypeptide binding]; other site
1091501002977	putative active site pocket [active]
1091501002978	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
1091501002979	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
1091501002980	DEAD/DEAH box helicase; Region: DEAD; pfam00270
1091501002981	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
1091501002982	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
1091501002983	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
1091501002984	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
1091501002985	active site
1091501002986	ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033
1091501002987	Domain of unknown function (DUF2017); Region: DUF2017; pfam09438
1091501002988	nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252
1091501002989	nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252
1091501002990	putative active site pocket [active]
1091501002991	cleavage site
1091501002992	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070
1091501002993	MPN+ (JAMM) motif; other site
1091501002994	Zinc-binding site [ion binding]; other site
1091501002995	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
1091501002996	MoaE interaction surface [polypeptide binding]; other site
1091501002997	MoeB interaction surface [polypeptide binding]; other site
1091501002998	thiocarboxylated glycine; other site
1091501002999	potential frameshift: common BLAST hit: gi|340626352|ref|YP_004744804.1| putative cysteine synthase B CYSM
1091501003000	Rhomboid family; Region: Rhomboid; cl11446
1091501003001	glutamate racemase; Provisional; Region: PRK00865
1091501003002	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
1091501003003	ribonuclease PH; Reviewed; Region: rph; PRK00173
1091501003004	Ribonuclease PH; Region: RNase_PH_bact; cd11362
1091501003005	hexamer interface [polypeptide binding]; other site
1091501003006	active site
1091501003007	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
1091501003008	active site
1091501003009	dimerization interface [polypeptide binding]; other site
1091501003010	Domain of unknown function (DUF3817); Region: DUF3817; pfam12823
1091501003011	Glucitol operon activator [Transcription]; Region: GutM; COG4578
1091501003012	acyl carrier protein; Validated; Region: PRK05883
1091501003013	potential frameshift: common BLAST hit: gi|340626361|ref|YP_004744813.1| putative polyketide synthase FADD33
1091501003014	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1091501003015	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1091501003016	active site
1091501003017	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
1091501003018	Siderophore biosynthesis protein domain; Region: AlcB; smart01006
1091501003019	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
1091501003020	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
1091501003021	FAD binding pocket [chemical binding]; other site
1091501003022	FAD binding motif [chemical binding]; other site
1091501003023	phosphate binding motif [ion binding]; other site
1091501003024	NAD binding pocket [chemical binding]; other site
1091501003025	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1091501003026	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
1091501003027	Walker A/P-loop; other site
1091501003028	ATP binding site [chemical binding]; other site
1091501003029	Q-loop/lid; other site
1091501003030	ABC transporter signature motif; other site
1091501003031	Walker B; other site
1091501003032	D-loop; other site
1091501003033	H-loop/switch region; other site
1091501003034	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
1091501003035	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1091501003036	Walker A/P-loop; other site
1091501003037	ATP binding site [chemical binding]; other site
1091501003038	Q-loop/lid; other site
1091501003039	ABC transporter signature motif; other site
1091501003040	Walker B; other site
1091501003041	D-loop; other site
1091501003042	H-loop/switch region; other site
1091501003043	potential frameshift: common BLAST hit: gi|340626366|ref|YP_004744818.1| putative 3-oxoacyl-[acyl-carrier protein] reductase FABG2
1091501003044	tetracycline repressor protein TetR; Provisional; Region: PRK13756
1091501003045	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1091501003046	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
1091501003047	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1091501003048	GAF domain; Region: GAF; pfam01590
1091501003049	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1091501003050	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1091501003051	metal binding site [ion binding]; metal-binding site
1091501003052	active site
1091501003053	I-site; other site
1091501003054	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1091501003055	hypothetical protein; Provisional; Region: PRK07877
1091501003056	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
1091501003057	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483
1091501003058	ATP binding site [chemical binding]; other site
1091501003059	substrate interface [chemical binding]; other site
1091501003060	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1091501003061	Predicted ATPase [General function prediction only]; Region: COG3903
1091501003062	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1091501003063	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1091501003064	DNA binding residues [nucleotide binding]
1091501003065	dimerization interface [polypeptide binding]; other site
1091501003066	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
1091501003067	cyclase homology domain; Region: CHD; cd07302
1091501003068	probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841
1091501003069	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
1091501003070	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1091501003071	PPE family; Region: PPE; pfam00823
1091501003072	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
1091501003073	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
1091501003074	anti sigma factor interaction site; other site
1091501003075	regulatory phosphorylation site [posttranslational modification]; other site
1091501003076	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
1091501003077	Beta-lactamase; Region: Beta-lactamase; pfam00144
1091501003078	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1091501003079	Protein of unknown function (DUF1396); Region: DUF1396; pfam07161
1091501003080	putative transposase OrfB; Reviewed; Region: PHA02517
1091501003081	HTH-like domain; Region: HTH_21; pfam13276
1091501003082	Integrase core domain; Region: rve; pfam00665
1091501003083	Integrase core domain; Region: rve_3; pfam13683
1091501003084	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1091501003085	Transposase; Region: HTH_Tnp_1; cl17663
1091501003086	Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424
1091501003087	Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831
1091501003088	malonyl-CoA binding site [chemical binding]; other site
1091501003089	dimer interface [polypeptide binding]; other site
1091501003090	active site
1091501003091	product binding site; other site
1091501003092	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
1091501003093	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
1091501003094	YcaO-like family; Region: YcaO; pfam02624
1091501003095	YcaO-like family; Region: YcaO; pfam02624
1091501003096	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1091501003097	S-adenosylmethionine binding site [chemical binding]; other site
1091501003098	Domain of unknown function (DUF222); Region: DUF222; pfam02720
1091501003099	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1091501003100	active site
1091501003101	bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; Provisional; Region: PRK05205
1091501003102	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
1091501003103	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
1091501003104	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1091501003105	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1091501003106	dihydroorotase; Validated; Region: pyrC; PRK09357
1091501003107	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1091501003108	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
1091501003109	active site
1091501003110	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
1091501003111	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
1091501003112	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
1091501003113	catalytic site [active]
1091501003114	subunit interface [polypeptide binding]; other site
1091501003115	potential frameshift: common BLAST hit: gi|339631451|ref|YP_004723093.1| carbamoyl-phosphate synthase large subunit
1091501003116	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
1091501003117	active site
1091501003118	dimer interface [polypeptide binding]; other site
1091501003119	PE family; Region: PE; pfam00934
1091501003120	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1091501003121	PPE family; Region: PPE; pfam00823
1091501003122	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
1091501003123	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
1091501003124	catalytic site [active]
1091501003125	G-X2-G-X-G-K; other site
1091501003126	DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690
1091501003127	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
1091501003128	Flavoprotein; Region: Flavoprotein; pfam02441
1091501003129	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
1091501003130	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
1091501003131	S-adenosylmethionine synthetase; Validated; Region: PRK05250
1091501003132	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
1091501003133	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
1091501003134	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
1091501003135	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
1091501003136	Cytochrome P450; Region: p450; cl12078
1091501003137	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1091501003138	potential frameshift: common BLAST hit: gi|339631462|ref|YP_004723104.1| transcriptional regulator
1091501003139	PE family; Region: PE; pfam00934
1091501003140	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
1091501003141	oligomeric interface; other site
1091501003142	putative active site [active]
1091501003143	homodimer interface [polypeptide binding]; other site
1091501003144	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
1091501003145	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1091501003146	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1091501003147	substrate binding pocket [chemical binding]; other site
1091501003148	potential frameshift: common BLAST hit: gi|339631467|ref|YP_004723109.1| lipase
1091501003149	Predicted membrane protein [Function unknown]; Region: COG3714
1091501003150	primosome assembly protein PriA; Provisional; Region: PRK14873
1091501003151	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1091501003152	S-adenosylmethionine binding site [chemical binding]; other site
1091501003153	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1091501003154	MarR family; Region: MarR; pfam01047
1091501003155	potential frameshift: common BLAST hit: gi|340626419|ref|YP_004744871.1| putative methyltransferase
1091501003156	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
1091501003157	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
1091501003158	putative active site [active]
1091501003159	substrate binding site [chemical binding]; other site
1091501003160	putative cosubstrate binding site; other site
1091501003161	catalytic site [active]
1091501003162	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
1091501003163	substrate binding site [chemical binding]; other site
1091501003164	potential frameshift: common BLAST hit: gi|340626421|ref|YP_004744873.1| putative FMU protein
1091501003165	potential frameshift: common BLAST hit: gi|340626422|ref|YP_004744874.1| putative ribulose-phosphate 3-epimerase RPE
1091501003166	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
1091501003167	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
1091501003168	catalytic motif [active]
1091501003169	Zn binding site [ion binding]; other site
1091501003170	RibD C-terminal domain; Region: RibD_C; pfam01872
1091501003171	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1091501003172	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1091501003173	Protein of unknown function (DUF1396); Region: DUF1396; pfam07161
1091501003174	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
1091501003175	Lumazine binding domain; Region: Lum_binding; pfam00677
1091501003176	Lumazine binding domain; Region: Lum_binding; pfam00677
1091501003177	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
1091501003178	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
1091501003179	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
1091501003180	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
1091501003181	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
1091501003182	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
1091501003183	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
1091501003184	dimerization interface [polypeptide binding]; other site
1091501003185	active site
1091501003186	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
1091501003187	homopentamer interface [polypeptide binding]; other site
1091501003188	active site
1091501003189	PknH-like extracellular domain; Region: PknH_C; pfam14032
1091501003190	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
1091501003191	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
1091501003192	putative sugar binding sites [chemical binding]; other site
1091501003193	Q-X-W motif; other site
1091501003194	potential frameshift: common BLAST hit: gi|340626434|ref|YP_004744886.1| putative excinuclease ABC subunit C-nuclease
1091501003195	P-loop ATPase protein family; Region: ATP_bind_2; cl15794
1091501003196	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
1091501003197	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
1091501003198	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1091501003199	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1091501003200	acyl-CoA synthetase; Provisional; Region: PRK13382
1091501003201	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
1091501003202	acyl-activating enzyme (AAE) consensus motif; other site
1091501003203	putative AMP binding site [chemical binding]; other site
1091501003204	putative active site [active]
1091501003205	putative CoA binding site [chemical binding]; other site
1091501003206	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1091501003207	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
1091501003208	putative acyl-acceptor binding pocket; other site
1091501003209	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
1091501003210	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
1091501003211	PE family; Region: PE; pfam00934
1091501003212	PE-PPE domain; Region: PE-PPE; pfam08237
1091501003213	Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077
1091501003214	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
1091501003215	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431
1091501003216	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
1091501003217	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1091501003218	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
1091501003219	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
1091501003220	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
1091501003221	Phosphoglycerate kinase; Region: PGK; pfam00162
1091501003222	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
1091501003223	substrate binding site [chemical binding]; other site
1091501003224	hinge regions; other site
1091501003225	ADP binding site [chemical binding]; other site
1091501003226	catalytic site [active]
1091501003227	triosephosphate isomerase; Provisional; Region: PRK14567
1091501003228	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
1091501003229	substrate binding site [chemical binding]; other site
1091501003230	dimer interface [polypeptide binding]; other site
1091501003231	catalytic triad [active]
1091501003232	SnoaL-like domain; Region: SnoaL_2; pfam12680
1091501003233	Preprotein translocase SecG subunit; Region: SecG; cl09123
1091501003234	PE family; Region: PE; pfam00934
1091501003235	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769
1091501003236	molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509
1091501003237	molybdopterin cofactor binding site [chemical binding]; other site
1091501003238	substrate binding site [chemical binding]; other site
1091501003239	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793
1091501003240	molybdopterin cofactor binding site; other site
1091501003241	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
1091501003242	Proteins of 100 residues with WXG; Region: WXG100; cl02005
1091501003243	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
1091501003244	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
1091501003245	putative active site [active]
1091501003246	glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534
1091501003247	Glucose-6-P dehydrogenase subunit [Carbohydrate transport and metabolism]; Region: COG3429
1091501003248	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
1091501003249	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
1091501003250	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
1091501003251	Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955
1091501003252	putative active site [active]
1091501003253	catalytic residue [active]
1091501003254	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
1091501003255	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
1091501003256	TPP-binding site [chemical binding]; other site
1091501003257	dimer interface [polypeptide binding]; other site
1091501003258	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1091501003259	PYR/PP interface [polypeptide binding]; other site
1091501003260	dimer interface [polypeptide binding]; other site
1091501003261	TPP binding site [chemical binding]; other site
1091501003262	PE family; Region: PE; pfam00934
1091501003263	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
1091501003264	UbiA prenyltransferase family; Region: UbiA; pfam01040
1091501003265	PE family; Region: PE; pfam00934
1091501003266	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
1091501003267	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
1091501003268	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
1091501003269	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
1091501003270	NADP binding site [chemical binding]; other site
1091501003271	dimer interface [polypeptide binding]; other site
1091501003272	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
1091501003273	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
1091501003274	ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025
1091501003275	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
1091501003276	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1091501003277	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1091501003278	Walker A/P-loop; other site
1091501003279	ATP binding site [chemical binding]; other site
1091501003280	Q-loop/lid; other site
1091501003281	ABC transporter signature motif; other site
1091501003282	Walker B; other site
1091501003283	D-loop; other site
1091501003284	H-loop/switch region; other site
1091501003285	carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459
1091501003286	Predicted transcriptional regulator [Transcription]; Region: COG2345
1091501003287	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1091501003288	putative DNA binding site [nucleotide binding]; other site
1091501003289	putative Zn2+ binding site [ion binding]; other site
1091501003290	Transcriptional regulator PadR-like family; Region: PadR; cl17335
1091501003291	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
1091501003292	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
1091501003293	protein-splicing catalytic site; other site
1091501003294	thioester formation/cholesterol transfer; other site
1091501003295	Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372
1091501003296	Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305
1091501003297	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
1091501003298	potential frameshift: common BLAST hit: gi|253799489|ref|YP_003032490.1| FeS assembly protein SufD
1091501003299	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1091501003300	Walker A/P-loop; other site
1091501003301	ATP binding site [chemical binding]; other site
1091501003302	ABC transporter; Region: ABC_tran; pfam00005
1091501003303	Q-loop/lid; other site
1091501003304	ABC transporter signature motif; other site
1091501003305	Walker B; other site
1091501003306	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
1091501003307	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
1091501003308	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1091501003309	catalytic residue [active]
1091501003310	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
1091501003311	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
1091501003312	active site
1091501003313	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
1091501003314	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
1091501003315	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
1091501003316	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1091501003317	active site
1091501003318	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
1091501003319	PE family; Region: PE; pfam00934
1091501003320	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
1091501003321	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1091501003322	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1091501003323	catalytic residues [active]
1091501003324	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1091501003325	catalytic residues [active]
1091501003326	enoyl-CoA hydratase; Provisional; Region: PRK05864
1091501003327	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1091501003328	substrate binding site [chemical binding]; other site
1091501003329	oxyanion hole (OAH) forming residues; other site
1091501003330	trimer interface [polypeptide binding]; other site
1091501003331	potential frameshift: common BLAST hit: gi|339631540|ref|YP_004723182.1| macrolide ABC transporter ATP-binding protein
1091501003332	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1091501003333	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1091501003334	potential frameshift: common BLAST hit: gi|339631543|ref|YP_004723185.1| aconitate hydratase
1091501003335	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1091501003336	NlpC/P60 family; Region: NLPC_P60; pfam00877
1091501003337	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1091501003338	NlpC/P60 family; Region: NLPC_P60; pfam00877
1091501003339	MoxR-like ATPases [General function prediction only]; Region: COG0714
1091501003340	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1091501003341	Walker A motif; other site
1091501003342	ATP binding site [chemical binding]; other site
1091501003343	Walker B motif; other site
1091501003344	arginine finger; other site
1091501003345	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
1091501003346	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
1091501003347	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
1091501003348	NAD(P) binding site [chemical binding]; other site
1091501003349	homotetramer interface [polypeptide binding]; other site
1091501003350	homodimer interface [polypeptide binding]; other site
1091501003351	active site
1091501003352	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889
1091501003353	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
1091501003354	NAD binding site [chemical binding]; other site
1091501003355	homotetramer interface [polypeptide binding]; other site
1091501003356	homodimer interface [polypeptide binding]; other site
1091501003357	substrate binding site [chemical binding]; other site
1091501003358	active site
1091501003359	ferrochelatase; Reviewed; Region: hemH; PRK00035
1091501003360	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
1091501003361	C-terminal domain interface [polypeptide binding]; other site
1091501003362	active site
1091501003363	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
1091501003364	active site
1091501003365	N-terminal domain interface [polypeptide binding]; other site
1091501003366	NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957
1091501003367	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
1091501003368	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
1091501003369	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817
1091501003370	Transposase domain (DUF772); Region: DUF772; pfam05598
1091501003371	Uncharacterized conserved protein [Function unknown]; Region: COG0398
1091501003372	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1091501003373	methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642
1091501003374	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677
1091501003375	heterodimer interface [polypeptide binding]; other site
1091501003376	substrate interaction site [chemical binding]; other site
1091501003377	Methylmalonyl-CoA mutase, C-terminal domain/subunit (cobalamin-binding) [Lipid metabolism]; Region: Sbm; COG2185
1091501003378	potential frameshift: common BLAST hit: gi|340626509|ref|YP_004744961.1| putative methylmalonyl-CoA mutase large subunit MUTB
1091501003379	Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337
1091501003380	potential frameshift: common BLAST hit: gi|340626512|ref|YP_004744964.1| putative transport system kinase
1091501003381	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1091501003382	Beta-lactamase; Region: Beta-lactamase; pfam00144
1091501003383	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1091501003384	Uncharacterized conserved protein [Function unknown]; Region: COG3360
1091501003385	NUDIX domain; Region: NUDIX; pfam00293
1091501003386	nudix motif; other site
1091501003387	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
1091501003388	Glycosyl hydrolase families 32 and 68, which for the clan GH-J; Region: GH_J; cd08979
1091501003389	active site
1091501003390	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
1091501003391	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
1091501003392	inhibitor-cofactor binding pocket; inhibition site
1091501003393	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1091501003394	catalytic residue [active]
1091501003395	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
1091501003396	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570
1091501003397	putative trimer interface [polypeptide binding]; other site
1091501003398	putative CoA binding site [chemical binding]; other site
1091501003399	Methyltransferase domain; Region: Methyltransf_12; pfam08242
1091501003400	S-adenosylmethionine binding site [chemical binding]; other site
1091501003401	Protein of unknown function (DUF2029); Region: DUF2029; pfam09594
1091501003402	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1091501003403	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1091501003404	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
1091501003405	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
1091501003406	NADP-binding site; other site
1091501003407	homotetramer interface [polypeptide binding]; other site
1091501003408	substrate binding site [chemical binding]; other site
1091501003409	homodimer interface [polypeptide binding]; other site
1091501003410	active site
1091501003411	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
1091501003412	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
1091501003413	NADP binding site [chemical binding]; other site
1091501003414	active site
1091501003415	putative substrate binding site [chemical binding]; other site
1091501003416	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
1091501003417	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
1091501003418	metal-binding site
1091501003419	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1091501003420	Protein of unknown function (DUF2910); Region: DUF2910; pfam11139
1091501003421	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1091501003422	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1091501003423	active site
1091501003424	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1091501003425	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1091501003426	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1091501003427	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1091501003428	active site
1091501003429	acyl-CoA synthetase; Validated; Region: PRK05850
1091501003430	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
1091501003431	acyl-activating enzyme (AAE) consensus motif; other site
1091501003432	active site
1091501003433	Transport protein; Region: actII; TIGR00833
1091501003434	MMPL family; Region: MMPL; pfam03176
1091501003435	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1091501003436	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1091501003437	S-adenosylmethionine binding site [chemical binding]; other site
1091501003438	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
1091501003439	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
1091501003440	homodimer interface [polypeptide binding]; other site
1091501003441	active site
1091501003442	TDP-binding site; other site
1091501003443	acceptor substrate-binding pocket; other site
1091501003444	potential frameshift: common BLAST hit: gi|339631598|ref|YP_004723240.1| polyketide synthase
1091501003445	potential frameshift: common BLAST hit: gi|339631598|ref|YP_004723240.1| polyketide synthase
1091501003446	acyl-CoA synthetase; Validated; Region: PRK05850
1091501003447	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
1091501003448	acyl-activating enzyme (AAE) consensus motif; other site
1091501003449	active site
1091501003450	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1091501003451	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1091501003452	NAD(P) binding site [chemical binding]; other site
1091501003453	Uncharacterized conserved protein [Function unknown]; Region: COG2128
1091501003454	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
1091501003455	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1091501003456	CoenzymeA binding site [chemical binding]; other site
1091501003457	subunit interaction site [polypeptide binding]; other site
1091501003458	PHB binding site; other site
1091501003459	Nitronate monooxygenase; Region: NMO; pfam03060
1091501003460	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
1091501003461	FMN binding site [chemical binding]; other site
1091501003462	substrate binding site [chemical binding]; other site
1091501003463	putative catalytic residue [active]
1091501003464	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1091501003465	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1091501003466	potential frameshift: common BLAST hit: gi|224989932|ref|YP_002644619.1| isoleucyl-tRNA synthetase
1091501003467	Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060
1091501003468	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039
1091501003469	Y-family of DNA polymerases; Region: PolY; cl12025
1091501003470	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
1091501003471	DNA polymerase IV; Provisional; Region: PRK03348
1091501003472	DNA binding site [nucleotide binding]
1091501003473	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
1091501003474	active site
1091501003475	homodimer interface [polypeptide binding]; other site
1091501003476	homotetramer interface [polypeptide binding]; other site
1091501003477	lipoprotein signal peptidase; Provisional; Region: PRK14764
1091501003478	lipoprotein signal peptidase; Provisional; Region: PRK14787
1091501003479	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1091501003480	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1091501003481	active site
1091501003482	Uncharacterized protein conserved in bacteria, putative lipoprotein [Function unknown]; Region: LprI; COG4461
1091501003483	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
1091501003484	Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864
1091501003485	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
1091501003486	apolar tunnel; other site
1091501003487	heme binding site [chemical binding]; other site
1091501003488	dimerization interface [polypeptide binding]; other site
1091501003489	short chain dehydrogenase; Provisional; Region: PRK05866
1091501003490	classical (c) SDRs; Region: SDR_c; cd05233
1091501003491	NAD(P) binding site [chemical binding]; other site
1091501003492	active site
1091501003493	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
1091501003494	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1091501003495	NAD(P) binding site [chemical binding]; other site
1091501003496	active site
1091501003497	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
1091501003498	hydrophobic ligand binding site; other site
1091501003499	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
1091501003500	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
1091501003501	active site
1091501003502	PHP Thumb interface [polypeptide binding]; other site
1091501003503	metal binding site [ion binding]; metal-binding site
1091501003504	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
1091501003505	generic binding surface II; other site
1091501003506	generic binding surface I; other site
1091501003507	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1091501003508	PPE family; Region: PPE; pfam00823
1091501003509	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1091501003510	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1091501003511	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
1091501003512	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
1091501003513	acyl-activating enzyme (AAE) consensus motif; other site
1091501003514	putative AMP binding site [chemical binding]; other site
1091501003515	putative active site [active]
1091501003516	putative CoA binding site [chemical binding]; other site
1091501003517	glycerol-3-phosphate acyltransferase; Reviewed; Region: PRK11915
1091501003518	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993
1091501003519	putative acyl-acceptor binding pocket; other site
1091501003520	fumarate reductase, flavoprotein subunit; Region: fum_red_Fp; TIGR01176
1091501003521	L-aspartate oxidase; Provisional; Region: PRK06175
1091501003522	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
1091501003523	fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385
1091501003524	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
1091501003525	Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C;  QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546
1091501003526	D-subunit interface [polypeptide binding]; other site
1091501003527	Iron-sulfur protein interface; other site
1091501003528	proximal quinone binding site [chemical binding]; other site
1091501003529	distal quinone binding site [chemical binding]; other site
1091501003530	Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547
1091501003531	Iron-sulfur protein interface; other site
1091501003532	proximal quinone binding site [chemical binding]; other site
1091501003533	C-subunit interface; other site
1091501003534	distal quinone binding site; other site
1091501003535	potential frameshift: common BLAST hit: gi|340626576|ref|YP_004745028.1| putative regulatory protein
1091501003536	MMPL family; Region: MMPL; pfam03176
1091501003537	Domain of unknown function (DUF385); Region: DUF385; pfam04075
1091501003538	threonine dehydratase; Validated; Region: PRK08639
1091501003539	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
1091501003540	tetramer interface [polypeptide binding]; other site
1091501003541	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1091501003542	catalytic residue [active]
1091501003543	C-terminal regulatory domain of Threonine dehydratase; Region: Thr_dehydrat_C; pfam00585
1091501003544	Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450
1091501003545	PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882
1091501003546	putative active site [active]
1091501003547	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
1091501003548	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
1091501003549	catalytic site [active]
1091501003550	active site
1091501003551	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
1091501003552	potential frameshift: common BLAST hit: gi|339631634|ref|YP_004723276.1| maltooligosyltrehalose synthase
1091501003553	potential frameshift: common BLAST hit: gi|339631635|ref|YP_004723277.1| maltooligosyltrehalose synthase
1091501003554	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1091501003555	NlpC/P60 family; Region: NLPC_P60; pfam00877
1091501003556	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964
1091501003557	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1091501003558	inhibitor-cofactor binding pocket; inhibition site
1091501003559	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1091501003560	catalytic residue [active]
1091501003561	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
1091501003562	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
1091501003563	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1091501003564	catalytic residue [active]
1091501003565	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
1091501003566	2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563
1091501003567	helicase-primase subunit BBLF4; Provisional; Region: PHA03311
1091501003568	Predicted phage phi-C31 gp36 major capsid-like protein [General function prediction only]; Region: COG4653
1091501003569	Phage capsid family; Region: Phage_capsid; pfam05065
1091501003570	Phage head maturation protease [General function prediction only]; Region: COG3740
1091501003571	Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: COG3747
1091501003572	potential frameshift: common BLAST hit: gi|148661377|ref|YP_001282900.1| phiRv1 phage protein
1091501003573	Protein of unknown function (DUF2742); Region: DUF2742; pfam10888
1091501003574	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1091501003575	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
1091501003576	catalytic residues [active]
1091501003577	Recombinase; Region: Recombinase; pfam07508
1091501003578	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
1091501003579	Domain of unknown function (DUF222); Region: DUF222; pfam02720
1091501003580	biotin synthase; Validated; Region: PRK06256
1091501003581	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1091501003582	FeS/SAM binding site; other site
1091501003583	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
1091501003584	Protein of unknown function (DUF2567); Region: DUF2567; pfam10821
1091501003585	Secretory lipase; Region: LIP; pfam03583
1091501003586	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
1091501003587	nudix motif; other site
1091501003588	quinolinate synthetase; Provisional; Region: PRK09375
1091501003589	L-aspartate oxidase; Provisional; Region: PRK07804
1091501003590	L-aspartate oxidase; Provisional; Region: PRK06175
1091501003591	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
1091501003592	Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275
1091501003593	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896
1091501003594	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
1091501003595	active site
1091501003596	dimerization interface [polypeptide binding]; other site
1091501003597	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1091501003598	S-adenosylmethionine binding site [chemical binding]; other site
1091501003599	deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026
1091501003600	potential frameshift: common BLAST hit: gi|253799363|ref|YP_003032364.1| histidinol dehydrogenase
1091501003601	histidinol-phosphate aminotransferase; Provisional; Region: PRK03317
1091501003602	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1091501003603	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1091501003604	homodimer interface [polypeptide binding]; other site
1091501003605	catalytic residue [active]
1091501003606	imidazoleglycerol-phosphate dehydratase; Validated; Region: hisB; PRK00951
1091501003607	4-fold oligomerization interface [polypeptide binding]; other site
1091501003608	putative active site pocket [active]
1091501003609	metal binding residues [ion binding]; metal-binding site
1091501003610	3-fold/trimer interface [polypeptide binding]; other site
1091501003611	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
1091501003612	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
1091501003613	putative active site [active]
1091501003614	oxyanion strand; other site
1091501003615	catalytic triad [active]
1091501003616	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
1091501003617	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
1091501003618	catalytic residues [active]
1091501003619	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
1091501003620	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1091501003621	active site
1091501003622	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
1091501003623	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
1091501003624	substrate binding site [chemical binding]; other site
1091501003625	glutamase interaction surface [polypeptide binding]; other site
1091501003626	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
1091501003627	Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387
1091501003628	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
1091501003629	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
1091501003630	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
1091501003631	catalytic triad [active]
1091501003632	anthranilate synthase component I; Provisional; Region: PRK13571
1091501003633	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
1091501003634	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
1091501003635	Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534
1091501003636	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
1091501003637	active site
1091501003638	ribulose/triose binding site [chemical binding]; other site
1091501003639	phosphate binding site [ion binding]; other site
1091501003640	substrate (anthranilate) binding pocket [chemical binding]; other site
1091501003641	product (indole) binding pocket [chemical binding]; other site
1091501003642	potential frameshift: common BLAST hit: gi|340626618|ref|YP_004745070.1| putative tryptophan synthase, subunit beta trpB
1091501003643	potential frameshift: common BLAST hit: gi|340626619|ref|YP_004745071.1| putative tryptophan synthase, alpha subunit trpA
1091501003644	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK13108
1091501003645	Prolipoprotein diacylglyceryltransferase [Cell envelope biogenesis, outer membrane]; Region: Lgt; COG0682
1091501003646	TM2 domain; Region: TM2; pfam05154
1091501003647	Protein of unknown function (DUF2752); Region: DUF2752; pfam10825
1091501003648	pyruvate kinase; Provisional; Region: PRK06247
1091501003649	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
1091501003650	domain interfaces; other site
1091501003651	active site
1091501003652	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
1091501003653	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
1091501003654	active site
1091501003655	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
1091501003656	catalytic triad [active]
1091501003657	dimer interface [polypeptide binding]; other site
1091501003658	Uncharacterized conserved protein [Function unknown]; Region: COG2898
1091501003659	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
1091501003660	thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868
1091501003661	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1091501003662	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1091501003663	Walker A/P-loop; other site
1091501003664	Walker A/P-loop; other site
1091501003665	ATP binding site [chemical binding]; other site
1091501003666	ATP binding site [chemical binding]; other site
1091501003667	Q-loop/lid; other site
1091501003668	ABC transporter signature motif; other site
1091501003669	Walker B; other site
1091501003670	D-loop; other site
1091501003671	potential frameshift: common BLAST hit: gi|339631677|ref|YP_004723319.1| ABC transporter ATP-binding protein
1091501003672	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
1091501003673	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
1091501003674	potential frameshift: common BLAST hit: gi|339631679|ref|YP_004723321.1| cytochrome D ubiquinol oxidase subunit I
1091501003675	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
1091501003676	potential frameshift: common BLAST hit: gi|224990007|ref|YP_002644694.1| membrane-anchored adenylyl cyclase
1091501003677	potential frameshift: common BLAST hit: gi|340626631|ref|YP_004745083.1| membrane-anchored adenylyl cyclase CYA
1091501003678	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
1091501003679	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1091501003680	active site
1091501003681	phosphorylation site [posttranslational modification]
1091501003682	intermolecular recognition site; other site
1091501003683	dimerization interface [polypeptide binding]; other site
1091501003684	ANTAR domain; Region: ANTAR; pfam03861
1091501003685	lipid-transfer protein; Provisional; Region: PRK06059
1091501003686	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
1091501003687	active site
1091501003688	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
1091501003689	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
1091501003690	DUF35 OB-fold domain; Region: DUF35; pfam01796
1091501003691	potential frameshift: common BLAST hit: gi|253799333|ref|YP_003032334.1| DNA polymerase I
1091501003692	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1091501003693	dephospho-CoA kinase/protein folding accessory domain-containing protein; Provisional; Region: coaE; PRK03333
1091501003694	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
1091501003695	CoA-binding site [chemical binding]; other site
1091501003696	ATP-binding [chemical binding]; other site
1091501003697	Uncharacterized conserved protein [Function unknown]; Region: GrpB; COG2320
1091501003698	Predicted RNA-binding protein, associated with RNAses E/G family [General function prediction only]; Region: COG2306
1091501003699	excinuclease ABC subunit B; Provisional; Region: PRK05298
1091501003700	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1091501003701	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1091501003702	nucleotide binding region [chemical binding]; other site
1091501003703	ATP-binding site [chemical binding]; other site
1091501003704	Ultra-violet resistance protein B; Region: UvrB; pfam12344
1091501003705	UvrB/uvrC motif; Region: UVR; pfam02151
1091501003706	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1091501003707	putative substrate translocation pore; other site
1091501003708	Predicted membrane protein [Function unknown]; Region: COG5305
1091501003709	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1091501003710	Ligand Binding Site [chemical binding]; other site
1091501003711	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
1091501003712	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
1091501003713	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1091501003714	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1091501003715	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
1091501003716	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
1091501003717	potential frameshift: common BLAST hit: gi|340626646|ref|YP_004745098.1| putative lysyl-tRNA synthetase 2 lysX
1091501003718	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
1091501003719	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
1091501003720	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
1091501003721	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
1091501003722	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
1091501003723	23S rRNA binding site [nucleotide binding]; other site
1091501003724	L21 binding site [polypeptide binding]; other site
1091501003725	L13 binding site [polypeptide binding]; other site
1091501003726	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
1091501003727	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1091501003728	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662
1091501003729	PE family; Region: PE; pfam00934
1091501003730	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
1091501003731	cyclase homology domain; Region: CHD; cd07302
1091501003732	nucleotidyl binding site; other site
1091501003733	metal binding site [ion binding]; metal-binding site
1091501003734	dimer interface [polypeptide binding]; other site
1091501003735	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
1091501003736	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
1091501003737	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
1091501003738	dimer interface [polypeptide binding]; other site
1091501003739	motif 1; other site
1091501003740	active site
1091501003741	motif 2; other site
1091501003742	motif 3; other site
1091501003743	potential frameshift: common BLAST hit: gi|340626656|ref|YP_004745108.1| putative phenylalanyl-tRNA synthetase, beta chain PheT
1091501003744	potential frameshift: common BLAST hit: gi|253799310|ref|YP_003032311.1| phenylalanyl-tRNA synthetase subunit beta
1091501003745	potential frameshift: common BLAST hit: gi|15841107|ref|NP_336144.1| PE PGRS family protein
1091501003746	potential frameshift: common BLAST hit: gi|340626658|ref|YP_004745110.1| putative N-acetl-gamma-glutamyl-phoshate reductase ARGC
1091501003747	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
1091501003748	heterotetramer interface [polypeptide binding]; other site
1091501003749	active site pocket [active]
1091501003750	cleavage site
1091501003751	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
1091501003752	feedback inhibition sensing region; other site
1091501003753	homohexameric interface [polypeptide binding]; other site
1091501003754	nucleotide binding site [chemical binding]; other site
1091501003755	N-acetyl-L-glutamate binding site [chemical binding]; other site
1091501003756	acetylornithine aminotransferase; Provisional; Region: argD; PRK03244
1091501003757	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1091501003758	inhibitor-cofactor binding pocket; inhibition site
1091501003759	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1091501003760	catalytic residue [active]
1091501003761	ornithine carbamoyltransferase; Provisional; Region: PRK00779
1091501003762	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1091501003763	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1091501003764	arginine repressor; Provisional; Region: PRK03341
1091501003765	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
1091501003766	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
1091501003767	potential frameshift: common BLAST hit: gi|339631714|ref|YP_004723356.1| argininosuccinate synthase
1091501003768	potential frameshift: common BLAST hit: gi|339631715|ref|YP_004723357.1| argininosuccinate lyase
1091501003769	potential frameshift: common BLAST hit: gi|340626666|ref|YP_004745118.1| putative chalcone synthase pks10
1091501003770	potential frameshift: common BLAST hit: gi|253799299|ref|YP_003032300.1| polyketide synthase
1091501003771	potential frameshift: common BLAST hit: gi|253799299|ref|YP_003032300.1| polyketide synthase
1091501003772	potential frameshift: common BLAST hit: gi|148822871|ref|YP_001287625.1| polyketide synthase pks8
1091501003773	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1091501003774	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956
1091501003775	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
1091501003776	putative NADP binding site [chemical binding]; other site
1091501003777	active site
1091501003778	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
1091501003779	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
1091501003780	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1091501003781	active site
1091501003782	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
1091501003783	Acyl transferase domain; Region: Acyl_transf_1; cl08282
1091501003784	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
1091501003785	Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831
1091501003786	dimer interface [polypeptide binding]; other site
1091501003787	active site
1091501003788	product binding site; other site
1091501003789	malonyl-CoA binding site [chemical binding]; other site
1091501003790	Cytochrome P450; Region: p450; cl12078
1091501003791	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1091501003792	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1091501003793	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1091501003794	ABC transporter; Region: ABC_tran_2; pfam12848
1091501003795	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1091501003796	Domain of unknown function (DUF427); Region: DUF427; cl00998
1091501003797	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1091501003798	putative substrate translocation pore; other site
1091501003799	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
1091501003800	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
1091501003801	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1091501003802	dimerization interface [polypeptide binding]; other site
1091501003803	putative DNA binding site [nucleotide binding]; other site
1091501003804	putative Zn2+ binding site [ion binding]; other site
1091501003805	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
1091501003806	active site residue [active]
1091501003807	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1091501003808	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1091501003809	ligand binding site [chemical binding]; other site
1091501003810	flexible hinge region; other site
1091501003811	Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970
1091501003812	putative catalytic residues [active]
1091501003813	potential frameshift: common BLAST hit: gi|340626682|ref|YP_004745134.1| putative lipoprotein DSBF
1091501003814	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1091501003815	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1091501003816	active site
1091501003817	ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221
1091501003818	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1091501003819	substrate binding pocket [chemical binding]; other site
1091501003820	membrane-bound complex binding site; other site
1091501003821	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
1091501003822	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1091501003823	FeS/SAM binding site; other site
1091501003824	DivIVA protein; Region: DivIVA; pfam05103
1091501003825	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
1091501003826	potential frameshift: common BLAST hit: gi|15841140|ref|NP_336177.1| acyl-CoA synthetase
1091501003827	Uncharacterized conserved protein [Function unknown]; Region: COG2835
1091501003828	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1091501003829	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1091501003830	ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025
1091501003831	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1091501003832	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1091501003833	ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864
1091501003834	Walker A/P-loop; other site
1091501003835	ATP binding site [chemical binding]; other site
1091501003836	Q-loop/lid; other site
1091501003837	ABC transporter signature motif; other site
1091501003838	Walker B; other site
1091501003839	D-loop; other site
1091501003840	H-loop/switch region; other site
1091501003841	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
1091501003842	active site
1091501003843	DNA binding site [nucleotide binding]
1091501003844	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
1091501003845	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
1091501003846	active site
1091501003847	HIGH motif; other site
1091501003848	dimer interface [polypeptide binding]; other site
1091501003849	KMSKS motif; other site
1091501003850	S4 RNA-binding domain; Region: S4; smart00363
1091501003851	RNA binding surface [nucleotide binding]; other site
1091501003852	Protein of unknown function (DUF732); Region: DUF732; pfam05305
1091501003853	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
1091501003854	Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344
1091501003855	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
1091501003856	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
1091501003857	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1091501003858	RNA binding surface [nucleotide binding]; other site
1091501003859	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1091501003860	S-adenosylmethionine binding site [chemical binding]; other site
1091501003861	potential frameshift: common BLAST hit: gi|340626700|ref|YP_004745152.1| Inorganic polyphosphate/ATP-NAD kinase ppnK
1091501003862	potential frameshift: common BLAST hit: gi|340626701|ref|YP_004745153.1| putative DNA repair protein RECN
1091501003863	potential frameshift: common BLAST hit: gi|339631750|ref|YP_004723392.1| recombination protein N
1091501003864	Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825
1091501003865	Thiamine pyrophosphokinase; Region: TPK; cl08415
1091501003866	Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555
1091501003867	CTP synthetase; Validated; Region: pyrG; PRK05380
1091501003868	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
1091501003869	Catalytic site [active]
1091501003870	active site
1091501003871	UTP binding site [chemical binding]; other site
1091501003872	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
1091501003873	active site
1091501003874	putative oxyanion hole; other site
1091501003875	catalytic triad [active]
1091501003876	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
1091501003877	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1091501003878	active site
1091501003879	DNA binding site [nucleotide binding]
1091501003880	Int/Topo IB signature motif; other site
1091501003881	Domain of unknown function (DUF222); Region: DUF222; pfam02720
1091501003882	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1091501003883	active site
1091501003884	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
1091501003885	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1091501003886	S-adenosylmethionine binding site [chemical binding]; other site
1091501003887	D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049
1091501003888	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1091501003889	PPE family; Region: PPE; pfam00823
1091501003890	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
1091501003891	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1091501003892	PPE family; Region: PPE; pfam00823
1091501003893	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
1091501003894	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
1091501003895	Sulfate transporter family; Region: Sulfate_transp; pfam00916
1091501003896	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
1091501003897	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1091501003898	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1091501003899	P-loop; other site
1091501003900	Magnesium ion binding site [ion binding]; other site
1091501003901	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1091501003902	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1091501003903	Magnesium ion binding site [ion binding]; other site
1091501003904	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
1091501003905	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
1091501003906	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1091501003907	RNA binding surface [nucleotide binding]; other site
1091501003908	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
1091501003909	active site
1091501003910	cytidylate kinase; Provisional; Region: cmk; PRK00023
1091501003911	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
1091501003912	CMP-binding site; other site
1091501003913	The sites determining sugar specificity; other site
1091501003914	potential frameshift: common BLAST hit: gi|340626720|ref|YP_004745172.1| putative GTP-binding protein ENGA
1091501003915	short chain dehydrogenase; Provisional; Region: PRK07060
1091501003916	classical (c) SDRs; Region: SDR_c; cd05233
1091501003917	NAD(P) binding site [chemical binding]; other site
1091501003918	active site
1091501003919	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1091501003920	Cupin domain; Region: Cupin_2; pfam07883
1091501003921	Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853
1091501003922	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1091501003923	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1091501003924	putative switch regulator; other site
1091501003925	non-specific DNA interactions [nucleotide binding]; other site
1091501003926	DNA binding site [nucleotide binding]
1091501003927	sequence specific DNA binding site [nucleotide binding]; other site
1091501003928	putative cAMP binding site [chemical binding]; other site
1091501003929	Bacterial transcriptional regulator; Region: IclR; pfam01614
1091501003930	PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873
1091501003931	putative active site [active]
1091501003932	homotetrameric interface [polypeptide binding]; other site
1091501003933	metal binding site [ion binding]; metal-binding site
1091501003934	biotin carboxylase-like protein; Validated; Region: PRK06524
1091501003935	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1091501003936	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1091501003937	Beta-lactamase; Region: Beta-lactamase; pfam00144
1091501003938	FAD binding domain; Region: FAD_binding_4; pfam01565
1091501003939	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1091501003940	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1091501003941	Berberine and berberine like; Region: BBE; pfam08031
1091501003942	TIGR03086 family protein; Region: TIGR03086
1091501003943	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
1091501003944	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
1091501003945	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
1091501003946	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1091501003947	Beta-lactamase; Region: Beta-lactamase; pfam00144
1091501003948	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1091501003949	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101
1091501003950	NAD(P) binding site [chemical binding]; other site
1091501003951	catalytic residues [active]
1091501003952	Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969
1091501003953	putative catalytic residue [active]
1091501003954	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes [Energy production and conversion]; Region: AceF; COG0508
1091501003955	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1091501003956	The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_1; cd09319
1091501003957	gating phenylalanine in ion channel; other site
1091501003958	The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_1; cd09319
1091501003959	potential frameshift: common BLAST hit: gi|253799222|ref|YP_003032223.1| nitrate reductase narX
1091501003960	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1091501003961	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
1091501003962	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1091501003963	Domain of unknown function (DUF1876); Region: DUF1876; pfam08962
1091501003964	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
1091501003965	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
1091501003966	Sulfate transporter family; Region: Sulfate_transp; pfam00916
1091501003967	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
1091501003968	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4423
1091501003969	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3742
1091501003970	putative active site [active]
1091501003971	Protein tyrosine kinase; Region: Pkinase_Tyr; pfam07714
1091501003972	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1091501003973	active site
1091501003974	ATP binding site [chemical binding]; other site
1091501003975	substrate binding site [chemical binding]; other site
1091501003976	activation loop (A-loop); other site
1091501003977	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
1091501003978	Thioredoxin; Region: Thioredoxin_4; cl17273
1091501003979	Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443
1091501003980	Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885
1091501003981	active site
1091501003982	metal binding site [ion binding]; metal-binding site
1091501003983	nudix motif; other site
1091501003984	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1091501003985	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1091501003986	active site
1091501003987	ATP binding site [chemical binding]; other site
1091501003988	substrate binding site [chemical binding]; other site
1091501003989	activation loop (A-loop); other site
1091501003990	potential frameshift: common BLAST hit: gi|339631800|ref|YP_004723442.1| ABC transporter ATP-binding protein
1091501003991	acyl-CoA synthetase; Provisional; Region: PRK13388
1091501003992	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1091501003993	acyl-activating enzyme (AAE) consensus motif; other site
1091501003994	AMP binding site [chemical binding]; other site
1091501003995	active site
1091501003996	CoA binding site [chemical binding]; other site
1091501003997	potential frameshift: common BLAST hit: gi|339631804|ref|YP_004723446.1| oxidoreductase
1091501003998	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1091501003999	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1091501004000	PPE family; Region: PPE; pfam00823
1091501004001	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1091501004002	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1091501004003	Domain of unknown function (DUF4185); Region: DUF4185; pfam13810
1091501004004	Phosphoesterase family; Region: Phosphoesterase; pfam04185
1091501004005	putative transposase OrfB; Reviewed; Region: PHA02517
1091501004006	HTH-like domain; Region: HTH_21; pfam13276
1091501004007	Integrase core domain; Region: rve; pfam00665
1091501004008	Integrase core domain; Region: rve_3; pfam13683
1091501004009	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1091501004010	Transposase; Region: HTH_Tnp_1; cl17663
1091501004011	Cutinase; Region: Cutinase; pfam01083
1091501004012	potential frameshift: common BLAST hit: gi|253799200|ref|YP_003032201.1| PE-PGRS family protein
1091501004013	potential frameshift: common BLAST hit: gi|57116905|ref|YP_177831.1| PE-PGRS family protein
1091501004014	PE family; Region: PE; pfam00934
1091501004015	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
1091501004016	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
1091501004017	Uncharacterized conserved protein [Function unknown]; Region: COG0393
1091501004018	Putative heavy-metal-binding; Region: YbjQ_1; cl00426
1091501004019	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1091501004020	Transposase; Region: HTH_Tnp_1; cl17663
1091501004021	putative transposase OrfB; Reviewed; Region: PHA02517
1091501004022	HTH-like domain; Region: HTH_21; pfam13276
1091501004023	Integrase core domain; Region: rve; pfam00665
1091501004024	Integrase core domain; Region: rve_3; pfam13683
1091501004025	Domain of unknown function (DUF222); Region: DUF222; pfam02720
1091501004026	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1091501004027	active site
1091501004028	putative transposase OrfB; Reviewed; Region: PHA02517
1091501004029	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
1091501004030	putative homotetramer interface [polypeptide binding]; other site
1091501004031	putative homodimer interface [polypeptide binding]; other site
1091501004032	putative allosteric switch controlling residues; other site
1091501004033	putative metal binding site [ion binding]; other site
1091501004034	putative homodimer-homodimer interface [polypeptide binding]; other site
1091501004035	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
1091501004036	PE family; Region: PE; pfam00934
1091501004037	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
1091501004038	Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234
1091501004039	metal binding site [ion binding]; metal-binding site
1091501004040	potential frameshift: common BLAST hit: gi|253799188|ref|YP_003032189.1| oxidoreductase
1091501004041	ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012
1091501004042	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
1091501004043	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1091501004044	Bacterial transcriptional regulator; Region: IclR; pfam01614
1091501004045	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1091501004046	FAD binding domain; Region: FAD_binding_4; pfam01565
1091501004047	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1091501004048	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1091501004049	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1091501004050	Cytochrome P450; Region: p450; cl12078
1091501004051	Domain of unknown function (DUF4407); Region: DUF4407; pfam14362
1091501004052	potential frameshift: common BLAST hit: gi|340626793|ref|YP_004745245.1| putative 4-alpha-glucanotransferase MALQ
1091501004053	Protein of unknown function (DUF690); Region: DUF690; pfam05108
1091501004054	type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924
1091501004055	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1091501004056	type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925
1091501004057	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1091501004058	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1091501004059	Cytochrome P450; Region: p450; cl12078
1091501004060	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1091501004061	PPE family; Region: PPE; pfam00823
1091501004062	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
1091501004063	PE family; Region: PE; pfam00934
1091501004064	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1091501004065	PPE family; Region: PPE; pfam00823
1091501004066	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1091501004067	PPE family; Region: PPE; pfam00823
1091501004068	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
1091501004069	PE family; Region: PE; pfam00934
1091501004070	WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930
1091501004071	Proteins of 100 residues with WXG; Region: WXG100; pfam06013
1091501004072	EspG family; Region: ESX-1_EspG; pfam14011
1091501004073	type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920
1091501004074	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
1091501004075	catalytic residues [active]
1091501004076	type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921
1091501004077	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306
1091501004078	active site
1091501004079	catalytic residues [active]
1091501004080	type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923
1091501004081	type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922
1091501004082	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1091501004083	Walker A motif; other site
1091501004084	ATP binding site [chemical binding]; other site
1091501004085	Walker B motif; other site
1091501004086	arginine finger; other site
1091501004087	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1091501004088	PPE family; Region: PPE; pfam00823
1091501004089	PE-PPE domain; Region: PE-PPE; pfam08237
1091501004090	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1091501004091	PPE family; Region: PPE; pfam00823
1091501004092	potential frameshift: common BLAST hit: gi|253799156|ref|YP_003032157.1| PPE family protein
1091501004093	PE family; Region: PE; pfam00934
1091501004094	Protein of unknown function (DUF732); Region: DUF732; pfam05305
1091501004095	PE family; Region: PE; pfam00934
1091501004096	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1091501004097	PPE family; Region: PPE; pfam00823
1091501004098	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1091501004099	PPE family; Region: PPE; pfam00823
1091501004100	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1091501004101	PPE family; Region: PPE; pfam00823
1091501004102	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
1091501004103	Protein of unknown function (DUF732); Region: DUF732; pfam05305
1091501004104	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
1091501004105	MgtC family; Region: MgtC; pfam02308
1091501004106	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
1091501004107	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1091501004108	Domain of unknown function (DUF4189); Region: DUF4189; pfam13827
1091501004109	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
1091501004110	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
1091501004111	hypothetical protein; Validated; Region: PRK07121
1091501004112	PE family; Region: PE; pfam00934
1091501004113	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
1091501004114	ABC transporter transmembrane region 2; Region: ABC_membrane_2; pfam06472
1091501004115	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
1091501004116	hypothetical protein; Provisional; Region: PRK05858
1091501004117	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1091501004118	PYR/PP interface [polypeptide binding]; other site
1091501004119	dimer interface [polypeptide binding]; other site
1091501004120	TPP binding site [chemical binding]; other site
1091501004121	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1091501004122	Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004
1091501004123	TPP-binding site; other site
1091501004124	dimer interface [polypeptide binding]; other site
1091501004125	potential frameshift: common BLAST hit: gi|339631874|ref|YP_004723516.1| preprotein translocase subunit SecA
1091501004126	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
1091501004127	Protein of unknown function (DUF1290); Region: DUF1290; cl01587
1091501004128	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879
1091501004129	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
1091501004130	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
1091501004131	lipoyl attachment site [posttranslational modification]; other site
1091501004132	Bifunctional nuclease; Region: DNase-RNase; pfam02577
1091501004133	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
1091501004134	DNA binding residues [nucleotide binding]
1091501004135	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1091501004136	putative dimer interface [polypeptide binding]; other site
1091501004137	potential frameshift: common BLAST hit: gi|253799125|ref|YP_003032126.1| glycine dehydrogenase
1091501004138	haloalkane dehalogenase; Provisional; Region: PRK03204
1091501004139	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1091501004140	putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976
1091501004141	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530
1091501004142	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
1091501004143	metal ion-dependent adhesion site (MIDAS); other site
1091501004144	Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728
1091501004145	active site
1091501004146	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
1091501004147	putative active site [active]
1091501004148	potential frameshift: common BLAST hit: gi|31793030|ref|NP_855523.1| PE-PGRS family protein
1091501004149	Domain of unknown function DUF21; Region: DUF21; pfam01595
1091501004150	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1091501004151	FOG: CBS domain [General function prediction only]; Region: COG0517
1091501004152	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
1091501004153	Domain of unknown function DUF21; Region: DUF21; pfam01595
1091501004154	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1091501004155	Transporter associated domain; Region: CorC_HlyC; smart01091
1091501004156	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
1091501004157	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
1091501004158	active site
1091501004159	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1091501004160	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
1091501004161	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
1091501004162	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
1091501004163	Predicted transcriptional regulator [Transcription]; Region: COG3682
1091501004164	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1091501004165	CoenzymeA binding site [chemical binding]; other site
1091501004166	subunit interaction site [polypeptide binding]; other site
1091501004167	PHB binding site; other site
1091501004168	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
1091501004169	alpha-gamma subunit interface [polypeptide binding]; other site
1091501004170	beta-gamma subunit interface [polypeptide binding]; other site
1091501004171	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
1091501004172	gamma-beta subunit interface [polypeptide binding]; other site
1091501004173	alpha-beta subunit interface [polypeptide binding]; other site
1091501004174	urease subunit alpha; Reviewed; Region: ureC; PRK13206
1091501004175	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
1091501004176	subunit interactions [polypeptide binding]; other site
1091501004177	active site
1091501004178	flap region; other site
1091501004179	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
1091501004180	UreF; Region: UreF; pfam01730
1091501004181	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1091501004182	UreD urease accessory protein; Region: UreD; cl00530
1091501004183	potential frameshift: common BLAST hit: gi|339631907|ref|YP_004723549.1| NADH dehydrogenase NDH
1091501004184	probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560
1091501004185	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1091501004186	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
1091501004187	classical (c) SDRs; Region: SDR_c; cd05233
1091501004188	gluconate 5-dehydrogenase; Provisional; Region: PRK08213
1091501004189	NAD(P) binding site [chemical binding]; other site
1091501004190	active site
1091501004191	ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725
1091501004192	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1091501004193	sulfate transport protein; Provisional; Region: cysT; CHL00187
1091501004194	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1091501004195	dimer interface [polypeptide binding]; other site
1091501004196	conserved gate region; other site
1091501004197	putative PBP binding loops; other site
1091501004198	ABC-ATPase subunit interface; other site
1091501004199	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
1091501004200	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1091501004201	Walker A/P-loop; other site
1091501004202	ATP binding site [chemical binding]; other site
1091501004203	Q-loop/lid; other site
1091501004204	ABC transporter signature motif; other site
1091501004205	Walker B; other site
1091501004206	D-loop; other site
1091501004207	H-loop/switch region; other site
1091501004208	TOBE domain; Region: TOBE; pfam03459
1091501004209	Fibronectin-attachment protein (FAP); Region: FAP; pfam07174
1091501004210	Predicted membrane protein [Function unknown]; Region: COG2261
1091501004211	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298
1091501004212	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822
1091501004213	putative NAD(P) binding site [chemical binding]; other site
1091501004214	putative substrate binding site [chemical binding]; other site
1091501004215	catalytic Zn binding site [ion binding]; other site
1091501004216	structural Zn binding site [ion binding]; other site
1091501004217	CAAX protease self-immunity; Region: Abi; pfam02517
1091501004218	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
1091501004219	MOSC domain; Region: MOSC; pfam03473
1091501004220	potential frameshift: common BLAST hit: gi|339631918|ref|YP_004723560.1| short-chain dehydrogenase
1091501004221	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
1091501004222	CoA-transferase family III; Region: CoA_transf_3; pfam02515
1091501004223	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
1091501004224	CoA-transferase family III; Region: CoA_transf_3; pfam02515
1091501004225	potential frameshift: common BLAST hit: gi|253799089|ref|YP_003032090.1| acetyl-CoA acetyltransferase
1091501004226	hypothetical protein; Provisional; Region: PRK12320
1091501004227	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1091501004228	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
1091501004229	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1091501004230	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1091501004231	Domain of unknown function (DUF385); Region: DUF385; pfam04075
1091501004232	Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304
1091501004233	Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809
1091501004234	active site
1091501004235	substrate binding site [chemical binding]; other site
1091501004236	FMN binding site [chemical binding]; other site
1091501004237	putative catalytic residues [active]
1091501004238	Uncharacterized conserved protein [Function unknown]; Region: COG5579
1091501004239	PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618
1091501004240	Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906
1091501004241	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
1091501004242	dinuclear metal binding motif [ion binding]; other site
1091501004243	potential frameshift: common BLAST hit: gi|340626885|ref|YP_004745337.1| putative integral membrane protein
1091501004244	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
1091501004245	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
1091501004246	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159
1091501004247	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1091501004248	Cytochrome P450; Region: p450; cl12078
1091501004249	Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481
1091501004250	short chain dehydrogenase; Provisional; Region: PRK08267
1091501004251	classical (c) SDR, subgroup 9; Region: SDR_c9; cd08931
1091501004252	putative NAD(P) binding site [chemical binding]; other site
1091501004253	active site
1091501004254	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
1091501004255	hydrophobic ligand binding site; other site
1091501004256	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
1091501004257	chorismate mutase; Provisional; Region: PRK09269
1091501004258	chorismate mutase, putative; Region: CM_mono2; TIGR01806
1091501004259	Putative esterase; Region: Esterase; pfam00756
1091501004260	Leucine carboxyl methyltransferase; Region: LCM; cl01306
1091501004261	Leucine carboxyl methyltransferase; Region: LCM; cl01306
1091501004262	Uncharacterized conserved protein [Function unknown]; Region: COG2353
1091501004263	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
1091501004264	Nitronate monooxygenase; Region: NMO; pfam03060
1091501004265	FMN binding site [chemical binding]; other site
1091501004266	substrate binding site [chemical binding]; other site
1091501004267	putative catalytic residue [active]
1091501004268	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 2; Region: FDH_like_2; cd08284
1091501004269	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1091501004270	catalytic Zn binding site [ion binding]; other site
1091501004271	NAD(P) binding site [chemical binding]; other site
1091501004272	structural Zn binding site [ion binding]; other site
1091501004273	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
1091501004274	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
1091501004275	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
1091501004276	putative active site [active]
1091501004277	dimerization interface [polypeptide binding]; other site
1091501004278	putative tRNAtyr binding site [nucleotide binding]; other site
1091501004279	Domain of unknown function DUF77; Region: DUF77; pfam01910
1091501004280	Macro domain, Unknown family 2. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_2; cd03330
1091501004281	putative ADP-ribose binding site [chemical binding]; other site
1091501004282	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1091501004283	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
1091501004284	cyclase homology domain; Region: CHD; cd07302
1091501004285	nucleotidyl binding site; other site
1091501004286	metal binding site [ion binding]; metal-binding site
1091501004287	dimer interface [polypeptide binding]; other site
1091501004288	potential frameshift: common BLAST hit: gi|339631954|ref|YP_004723596.1| CINA-like protein CINA
1091501004289	putative sialic acid transporter; Region: 2A0112; TIGR00891
1091501004290	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1091501004291	putative substrate translocation pore; other site
1091501004292	Predicted membrane protein [Function unknown]; Region: COG1950
1091501004293	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
1091501004294	anti sigma factor interaction site; other site
1091501004295	regulatory phosphorylation site [posttranslational modification]; other site
1091501004296	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1091501004297	Domain of unknown function (DUF4262); Region: DUF4262; pfam14081
1091501004298	potential frameshift: common BLAST hit: gi|340626917|ref|YP_004745369.1| catalase-peroxidase-peroxynitritase T KATG
1091501004299	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1091501004300	metal binding site 2 [ion binding]; metal-binding site
1091501004301	putative DNA binding helix; other site
1091501004302	metal binding site 1 [ion binding]; metal-binding site
1091501004303	dimer interface [polypeptide binding]; other site
1091501004304	structural Zn2+ binding site [ion binding]; other site
1091501004305	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
1091501004306	substrate binding site [chemical binding]; other site
1091501004307	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
1091501004308	substrate binding site [chemical binding]; other site
1091501004309	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1091501004310	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1091501004311	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
1091501004312	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
1091501004313	tetramer interface [polypeptide binding]; other site
1091501004314	active site
1091501004315	Mg2+/Mn2+ binding site [ion binding]; other site
1091501004316	Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435
1091501004317	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1091501004318	PPE family; Region: PPE; pfam00823
1091501004319	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1091501004320	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1091501004321	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1091501004322	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1091501004323	PPE family; Region: PPE; pfam00823
1091501004324	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1091501004325	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1091501004326	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
1091501004327	putative hydrophobic ligand binding site [chemical binding]; other site
1091501004328	protein interface [polypeptide binding]; other site
1091501004329	gate; other site
1091501004330	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1091501004331	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
1091501004332	putative acyl-acceptor binding pocket; other site
1091501004333	potential frameshift: common BLAST hit: gi|224990310|ref|YP_002644997.1| lipoprotein
1091501004334	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1091501004335	Beta-lactamase; Region: Beta-lactamase; pfam00144
1091501004336	potential frameshift: common BLAST hit: gi|340626933|ref|YP_004745385.1| putative lipase LIPD
1091501004337	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1091501004338	Beta-lactamase; Region: Beta-lactamase; pfam00144
1091501004339	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
1091501004340	active site
1091501004341	Domain of unknown function (DUF1942); Region: DUF1942; pfam09167
1091501004342	Uncharacterized conserved protein [Function unknown]; Region: COG3361
1091501004343	short chain dehydrogenase; Provisional; Region: PRK05867
1091501004344	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1091501004345	NAD(P) binding site [chemical binding]; other site
1091501004346	active site
1091501004347	TIGR03085 family protein; Region: TIGR03085
1091501004348	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
1091501004349	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
1091501004350	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
1091501004351	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
1091501004352	conserved cys residue [active]
1091501004353	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1091501004354	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1091501004355	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
1091501004356	dimer interface [polypeptide binding]; other site
1091501004357	catalytic triad [active]
1091501004358	peroxidatic and resolving cysteines [active]
1091501004359	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1091501004360	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
1091501004361	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
1091501004362	active site
1091501004363	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1091501004364	Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152
1091501004365	FAD binding site [chemical binding]; other site
1091501004366	substrate binding site [chemical binding]; other site
1091501004367	catalytic base [active]
1091501004368	enoyl-CoA hydratase; Provisional; Region: PRK08290
1091501004369	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1091501004370	substrate binding site [chemical binding]; other site
1091501004371	oxyanion hole (OAH) forming residues; other site
1091501004372	trimer interface [polypeptide binding]; other site
1091501004373	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1091501004374	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
1091501004375	anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872
1091501004376	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1091501004377	catalytic loop [active]
1091501004378	iron binding site [ion binding]; other site
1091501004379	Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209
1091501004380	FAD binding pocket [chemical binding]; other site
1091501004381	FAD binding motif [chemical binding]; other site
1091501004382	phosphate binding motif [ion binding]; other site
1091501004383	beta-alpha-beta structure motif; other site
1091501004384	NAD binding pocket [chemical binding]; other site
1091501004385	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1091501004386	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1091501004387	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
1091501004388	3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108
1091501004389	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
1091501004390	GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807
1091501004391	dimerization interface [polypeptide binding]; other site
1091501004392	active site
1091501004393	classical (c) SDR, subgroup 12; Region: SDR_c12; cd08944
1091501004394	putative NAD(P) binding site [chemical binding]; other site
1091501004395	active site
1091501004396	homodimer interface [polypeptide binding]; other site
1091501004397	Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337
1091501004398	Domain of unknown function (DUF222); Region: DUF222; pfam02720
1091501004399	Domain of unknown function (DUF222); Region: DUF222; pfam02720
1091501004400	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1091501004401	active site
1091501004402	Plasmid stability protein [General function prediction only]; Region: StbC; COG4691
1091501004403	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: VapC; COG1487
1091501004404	Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973
1091501004405	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1091501004406	non-specific DNA binding site [nucleotide binding]; other site
1091501004407	salt bridge; other site
1091501004408	sequence-specific DNA binding site [nucleotide binding]; other site
1091501004409	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
1091501004410	Uncharacterized protein family (UPF0156); Region: RHH_2; pfam03693
1091501004411	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
1091501004412	putative active site [active]
1091501004413	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
1091501004414	potential frameshift: common BLAST hit: gi|339632015|ref|YP_004723657.1| TetR family transcriptional regulator
1091501004415	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
1091501004416	Permease; Region: Permease; pfam02405
1091501004417	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
1091501004418	Permease; Region: Permease; pfam02405
1091501004419	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
1091501004420	mce related protein; Region: MCE; pfam02470
1091501004421	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
1091501004422	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
1091501004423	mce related protein; Region: MCE; pfam02470
1091501004424	potential frameshift: common BLAST hit: gi|253798984|ref|YP_003031985.1| MCE-family protein mce3C
1091501004425	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
1091501004426	mce related protein; Region: MCE; pfam02470
1091501004427	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
1091501004428	mce related protein; Region: MCE; pfam02470
1091501004429	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
1091501004430	mce related protein; Region: MCE; pfam02470
1091501004431	Protein of unknown function (DUF732); Region: DUF732; pfam05305
1091501004432	YacP-like NYN domain; Region: NYN_YacP; cl01491
1091501004433	Peptidase family M48; Region: Peptidase_M48; pfam01435
1091501004434	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1091501004435	S-adenosylmethionine binding site [chemical binding]; other site
1091501004436	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
1091501004437	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
1091501004438	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
1091501004439	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
1091501004440	dimer interface [polypeptide binding]; other site
1091501004441	putative radical transfer pathway; other site
1091501004442	diiron center [ion binding]; other site
1091501004443	tyrosyl radical; other site
1091501004444	PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871
1091501004445	putative active site [active]
1091501004446	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4423
1091501004447	PE family; Region: PE; pfam00934
1091501004448	Cutinase; Region: Cutinase; pfam01083
1091501004449	Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594
1091501004450	potential frameshift: common BLAST hit: gi|340626998|ref|YP_004745450.1| putative transcriptional regulatory protein
1091501004451	potential frameshift: common BLAST hit: gi|340626999|ref|YP_004745451.1| putative integral membrane protein
1091501004452	Cellulose binding domain; Region: CBM_2; pfam00553
1091501004453	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1091501004454	S-adenosylmethionine binding site [chemical binding]; other site
1091501004455	Uncharacterized conserved protein [Function unknown]; Region: COG5654
1091501004456	putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293
1091501004457	Protein of unknown function (DUF2384); Region: DUF2384; pfam09722
1091501004458	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1091501004459	Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337
1091501004460	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
1091501004461	potential frameshift: common BLAST hit: gi|339632031|ref|YP_004723673.1| ATPase P
1091501004462	potential frameshift: common BLAST hit: gi|339632031|ref|YP_004723673.1| ATPase P
1091501004463	Protein of unknown function (DUF1490); Region: DUF1490; pfam07371
1091501004464	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1091501004465	dimerization interface [polypeptide binding]; other site
1091501004466	putative DNA binding site [nucleotide binding]; other site
1091501004467	putative Zn2+ binding site [ion binding]; other site
1091501004468	Hemerythrin-like domain; Region: Hr-like; cd12108
1091501004469	Fe binding site [ion binding]; other site
1091501004470	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1091501004471	Ligand Binding Site [chemical binding]; other site
1091501004472	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1091501004473	Ligand Binding Site [chemical binding]; other site
1091501004474	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
1091501004475	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
1091501004476	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1091501004477	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
1091501004478	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1091501004479	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
1091501004480	Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435
1091501004481	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
1091501004482	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
1091501004483	tetramer interface [polypeptide binding]; other site
1091501004484	active site
1091501004485	Mg2+/Mn2+ binding site [ion binding]; other site
1091501004486	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
1091501004487	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
1091501004488	Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884
1091501004489	3beta17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 3beta-17beta-HSD_like_SDR_c; cd05341
1091501004490	homotetramer interface [polypeptide binding]; other site
1091501004491	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1091501004492	NAD binding site [chemical binding]; other site
1091501004493	homodimer interface [polypeptide binding]; other site
1091501004494	active site
1091501004495	Methyltransferase domain; Region: Methyltransf_11; pfam08241
1091501004496	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
1091501004497	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187
1091501004498	Predicted kinase [General function prediction only]; Region: COG0645
1091501004499	AAA domain; Region: AAA_17; pfam13207
1091501004500	Universal stress protein family; Region: Usp; pfam00582
1091501004501	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1091501004502	Ligand Binding Site [chemical binding]; other site
1091501004503	potential frameshift: common BLAST hit: gi|148823221|ref|YP_001287975.1| trehalose-6-phosphate phosphatase otsB1
1091501004504	potential frameshift: common BLAST hit: gi|148823221|ref|YP_001287975.1| trehalose-6-phosphate phosphatase otsB1
1091501004505	Ferredoxin [Energy production and conversion]; Region: COG1146
1091501004506	Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450
1091501004507	PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882
1091501004508	putative active site [active]
1091501004509	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1091501004510	MarR family; Region: MarR_2; pfam12802
1091501004511	Phage envelope protein [General function prediction only]; Region: COG5562
1091501004512	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1091501004513	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
1091501004514	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
1091501004515	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
1091501004516	Domain of unknown function (DUF222); Region: DUF222; pfam02720
1091501004517	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1091501004518	active site
1091501004519	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1091501004520	sequence-specific DNA binding site [nucleotide binding]; other site
1091501004521	salt bridge; other site
1091501004522	Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856
1091501004523	Uncharacterized conserved protein [Function unknown]; Region: COG2442
1091501004524	Predicted helicase [General function prediction only]; Region: COG4889
1091501004525	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1091501004526	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1091501004527	non-specific DNA binding site [nucleotide binding]; other site
1091501004528	salt bridge; other site
1091501004529	sequence-specific DNA binding site [nucleotide binding]; other site
1091501004530	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4683
1091501004531	Restriction endonuclease; Region: Mrr_cat_2; pfam13156
1091501004532	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1091501004533	Type III restriction enzyme, res subunit; Region: ResIII; pfam04851
1091501004534	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1091501004535	ATP binding site [chemical binding]; other site
1091501004536	putative Mg++ binding site [ion binding]; other site
1091501004537	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1091501004538	Ligand Binding Site [chemical binding]; other site
1091501004539	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1091501004540	Ligand Binding Site [chemical binding]; other site
1091501004541	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1091501004542	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1091501004543	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1091501004544	Histidine kinase; Region: HisKA_3; pfam07730
1091501004545	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1091501004546	Ligand Binding Site [chemical binding]; other site
1091501004547	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
1091501004548	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
1091501004549	putative substrate binding site [chemical binding]; other site
1091501004550	putative ATP binding site [chemical binding]; other site
1091501004551	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
1091501004552	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
1091501004553	putative dimer interface [polypeptide binding]; other site
1091501004554	hypothetical protein; Provisional; Region: PRK07877
1091501004555	Protein of unknown function (DUF3097); Region: DUF3097; pfam11296
1091501004556	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1091501004557	putative DNA binding site [nucleotide binding]; other site
1091501004558	dimerization interface [polypeptide binding]; other site
1091501004559	putative Zn2+ binding site [ion binding]; other site
1091501004560	Ligand-binding SRPBCC domain of Micromonospora echinospora CalC and related proteins; Region: SRPBCC_CalC; cd08891
1091501004561	putative hydrophobic ligand binding site [chemical binding]; other site
1091501004562	CLM binding site; other site
1091501004563	L1 loop; other site
1091501004564	DNA binding site [nucleotide binding]
1091501004565	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
1091501004566	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
1091501004567	MDMPI C-terminal domain; Region: MDMPI_C; pfam07398
1091501004568	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
1091501004569	ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207
1091501004570	nucleophile elbow; other site
1091501004571	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
1091501004572	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
1091501004573	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1091501004574	Walker A/P-loop; other site
1091501004575	ATP binding site [chemical binding]; other site
1091501004576	Q-loop/lid; other site
1091501004577	ABC transporter signature motif; other site
1091501004578	Walker B; other site
1091501004579	D-loop; other site
1091501004580	H-loop/switch region; other site
1091501004581	TOBE domain; Region: TOBE_2; pfam08402
1091501004582	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1091501004583	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1091501004584	dimer interface [polypeptide binding]; other site
1091501004585	conserved gate region; other site
1091501004586	putative PBP binding loops; other site
1091501004587	ABC-ATPase subunit interface; other site
1091501004588	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1091501004589	dimer interface [polypeptide binding]; other site
1091501004590	conserved gate region; other site
1091501004591	putative PBP binding loops; other site
1091501004592	ABC-ATPase subunit interface; other site
1091501004593	potential frameshift: common BLAST hit: gi|339632081|ref|YP_004723723.1| sugar-binding lipoprotein
1091501004594	Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136
1091501004595	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
1091501004596	Isochorismatase family; Region: Isochorismatase; pfam00857
1091501004597	catalytic triad [active]
1091501004598	metal binding site [ion binding]; metal-binding site
1091501004599	conserved cis-peptide bond; other site
1091501004600	Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861
1091501004601	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
1091501004602	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1091501004603	substrate binding pocket [chemical binding]; other site
1091501004604	catalytic triad [active]
1091501004605	potential frameshift: common BLAST hit: gi|339632088|ref|YP_004723730.1| polyketide synthase
1091501004606	potential frameshift: common BLAST hit: gi|339632088|ref|YP_004723730.1| polyketide synthase
1091501004607	potential frameshift: common BLAST hit: gi|339632088|ref|YP_004723730.1| polyketide synthase
1091501004608	potential frameshift: common BLAST hit: gi|224990428|ref|YP_002645115.1| polyketide synthase
1091501004609	Domain of unknown function (DUF4109); Region: DUF4109; pfam13397
1091501004610	potential frameshift: common BLAST hit: gi|339632091|ref|YP_004723733.1| polyprenol-monophosphomannose synthase
1091501004611	potential frameshift: common BLAST hit: gi|339632091|ref|YP_004723733.1| polyprenol-monophosphomannose synthase
1091501004612	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
1091501004613	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
1091501004614	active site
1091501004615	phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463
1091501004616	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
1091501004617	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
1091501004618	30S ribosomal protein S18; Provisional; Region: PRK13401
1091501004619	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
1091501004620	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
1091501004621	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
1091501004622	PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666
1091501004623	potential frameshift: common BLAST hit: gi|253798882|ref|YP_003031883.1| cobaltochelatase subunit CobN
1091501004624	PemK-like protein; Region: PemK; pfam02452
1091501004625	precorrin-3B synthase; Region: CobG; TIGR02435
1091501004626	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1091501004627	precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285
1091501004628	Precorrin-8X methylmutase; Region: CbiC; pfam02570
1091501004629	potential frameshift: common BLAST hit: gi|339632106|ref|YP_004723748.1| bifunctional protein, CobI-CobJ fusion protein:
1091501004630	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1091501004631	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1091501004632	S-adenosylmethionine binding site [chemical binding]; other site
1091501004633	Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367
1091501004634	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
1091501004635	RNA polymerase sigma factor SigC; Reviewed; Region: PRK09649
1091501004636	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1091501004637	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1091501004638	DNA binding residues [nucleotide binding]
1091501004639	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
1091501004640	Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922
1091501004641	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
1091501004642	active site
1091501004643	SAM binding site [chemical binding]; other site
1091501004644	homodimer interface [polypeptide binding]; other site
1091501004645	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
1091501004646	active site
1091501004647	putative homodimer interface [polypeptide binding]; other site
1091501004648	SAM binding site [chemical binding]; other site
1091501004649	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
1091501004650	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1091501004651	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1091501004652	NAD(P) binding site [chemical binding]; other site
1091501004653	active site
1091501004654	PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618
1091501004655	Catalytic domain of uncharacterized Mycobacterium tuberculosis Rv2075c-like proteins; Region: PI-PLCc_Rv2075c_like; cd08590
1091501004656	putative active site [active]
1091501004657	catalytic site [active]
1091501004658	putative metal binding site [ion binding]; other site
1091501004659	C-type lectin (CTL)/C-type lectin-like (CTLD) domain; Region: CLECT; cl02432
1091501004660	Protein of unknown function (DUF2563); Region: DUF2563; pfam10817
1091501004661	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1091501004662	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1091501004663	active site
1091501004664	ATP binding site [chemical binding]; other site
1091501004665	substrate binding site [chemical binding]; other site
1091501004666	activation loop (A-loop); other site
1091501004667	PknH-like extracellular domain; Region: PknH_C; pfam14032
1091501004668	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1091501004669	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
1091501004670	active site
1091501004671	5'-3' exonuclease, N-terminal resolvase-like domain; Region: 5_3_exonuc_N; pfam02739
1091501004672	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
1091501004673	active site
1091501004674	metal binding site 1 [ion binding]; metal-binding site
1091501004675	putative 5' ssDNA interaction site; other site
1091501004676	metal binding site 3; metal-binding site
1091501004677	metal binding site 2 [ion binding]; metal-binding site
1091501004678	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
1091501004679	putative DNA binding site [nucleotide binding]; other site
1091501004680	putative metal binding site [ion binding]; other site
1091501004681	Domain of unknown function (DUF4333); Region: DUF4333; pfam14230
1091501004682	potential frameshift: common BLAST hit: gi|253798849|ref|YP_003031850.1| ATP-dependent DNA helicase helY
1091501004683	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
1091501004684	twin arginine translocase protein A; Provisional; Region: tatA; PRK00575
1091501004685	mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416
1091501004686	Predicted transcriptional regulator [Transcription]; Region: COG2378
1091501004687	WYL domain; Region: WYL; pfam13280
1091501004688	PE family; Region: PE; pfam00934
1091501004689	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
1091501004690	SNF2 Helicase protein; Region: DUF3670; pfam12419
1091501004691	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1091501004692	ATP binding site [chemical binding]; other site
1091501004693	putative Mg++ binding site [ion binding]; other site
1091501004694	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
1091501004695	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1091501004696	nucleotide binding region [chemical binding]; other site
1091501004697	ATP-binding site [chemical binding]; other site
1091501004698	Uncharacterized conserved protein [Function unknown]; Region: COG4279
1091501004699	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
1091501004700	putative active site [active]
1091501004701	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1091501004702	Transposase; Region: HTH_Tnp_1; cl17663
1091501004703	putative transposase OrfB; Reviewed; Region: PHA02517
1091501004704	HTH-like domain; Region: HTH_21; pfam13276
1091501004705	Integrase core domain; Region: rve; pfam00665
1091501004706	Integrase core domain; Region: rve_3; pfam13683
1091501004707	PE family; Region: PE; pfam00934
1091501004708	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1091501004709	PPE family; Region: PPE; pfam00823
1091501004710	proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691
1091501004711	proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906
1091501004712	active site
1091501004713	proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690
1091501004714	proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906
1091501004715	active site
1091501004716	Pup-like protein; Region: Pup; pfam05639
1091501004717	proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688
1091501004718	proteasome ATPase; Region: pup_AAA; TIGR03689
1091501004719	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1091501004720	Walker A motif; other site
1091501004721	ATP binding site [chemical binding]; other site
1091501004722	Walker B motif; other site
1091501004723	arginine finger; other site
1091501004724	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
1091501004725	Protein of unknown function (DUF503); Region: DUF503; cl00669
1091501004726	tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519
1091501004727	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1091501004728	RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887
1091501004729	Predicted membrane protein [Function unknown]; Region: COG3918
1091501004730	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
1091501004731	ATP phosphoribosyltransferase; Region: hisG; TIGR00070
1091501004732	ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455
1091501004733	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547
1091501004734	homodimer interface [polypeptide binding]; other site
1091501004735	putative metal binding site [ion binding]; other site
1091501004736	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1091501004737	PPE family; Region: PPE; pfam00823
1091501004738	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
1091501004739	5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082
1091501004740	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
1091501004741	substrate binding pocket [chemical binding]; other site
1091501004742	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
1091501004743	B12 binding site [chemical binding]; other site
1091501004744	cobalt ligand [ion binding]; other site
1091501004745	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
1091501004746	PAC2 family; Region: PAC2; cl00847
1091501004747	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
1091501004748	short chain dehydrogenase; Provisional; Region: PRK05872
1091501004749	classical (c) SDRs; Region: SDR_c; cd05233
1091501004750	NAD(P) binding site [chemical binding]; other site
1091501004751	active site
1091501004752	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
1091501004753	cysteinyl-tRNA synthetase; Provisional; Region: PRK12418
1091501004754	active site
1091501004755	HIGH motif; other site
1091501004756	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1091501004757	active site
1091501004758	KMSKS motif; other site
1091501004759	Anticodon-binding domain of cysteinyl tRNA synthetases and domain found in MshC; Region: Anticodon_Ia_Cys_like; cd07955
1091501004760	putative tRNA binding surface [nucleotide binding]; other site
1091501004761	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
1091501004762	active site
1091501004763	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
1091501004764	conserved hypothetical protein; Region: TIGR03843
1091501004765	conserved hypothetical protein; Region: TIGR03847
1091501004766	potential frameshift: common BLAST hit: gi|253798801|ref|YP_003031802.1| UDP pyrophosphate phosphatase
1091501004767	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
1091501004768	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
1091501004769	quinone interaction residues [chemical binding]; other site
1091501004770	active site
1091501004771	catalytic residues [active]
1091501004772	FMN binding site [chemical binding]; other site
1091501004773	substrate binding site [chemical binding]; other site
1091501004774	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
1091501004775	substrate binding site [chemical binding]; other site
1091501004776	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483
1091501004777	putative addiction module component, TIGR02574 family; Region: stabl_TIGR02574
1091501004778	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1091501004779	active site
1091501004780	DivIVA domain; Region: DivI1A_domain; TIGR03544
1091501004781	Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599
1091501004782	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
1091501004783	Predicted integral membrane protein [Function unknown]; Region: COG0762
1091501004784	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799
1091501004785	cell division protein FtsZ; Validated; Region: PRK09330
1091501004786	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
1091501004787	nucleotide binding site [chemical binding]; other site
1091501004788	SulA interaction site; other site
1091501004789	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
1091501004790	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
1091501004791	Cell division protein FtsQ; Region: FtsQ; pfam03799
1091501004792	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
1091501004793	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1091501004794	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1091501004795	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1091501004796	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
1091501004797	undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Region: murG; TIGR01133
1091501004798	active site
1091501004799	homodimer interface [polypeptide binding]; other site
1091501004800	potential frameshift: common BLAST hit: gi|339632186|ref|YP_004723828.1| FtsW-like protein FtsW
1091501004801	potential frameshift: common BLAST hit: gi|224990531|ref|YP_002645218.1| UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase
1091501004802	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
1091501004803	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
1091501004804	Mg++ binding site [ion binding]; other site
1091501004805	putative catalytic motif [active]
1091501004806	putative substrate binding site [chemical binding]; other site
1091501004807	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143
1091501004808	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1091501004809	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1091501004810	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
1091501004811	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1091501004812	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1091501004813	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1091501004814	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
1091501004815	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1091501004816	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
1091501004817	PE family; Region: PE; pfam00934
1091501004818	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
1091501004819	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1091501004820	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1091501004821	Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275
1091501004822	MraW methylase family; Region: Methyltransf_5; pfam01795
1091501004823	potential frameshift: common BLAST hit: gi|253798769|ref|YP_003031770.1| cell division protein MraZ
1091501004824	putative transposase OrfB; Reviewed; Region: PHA02517
1091501004825	HTH-like domain; Region: HTH_21; pfam13276
1091501004826	Integrase core domain; Region: rve; pfam00665
1091501004827	Integrase core domain; Region: rve_3; pfam13683
1091501004828	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1091501004829	Transposase; Region: HTH_Tnp_1; cl17663
1091501004830	Protein of unknown function (DUF3153); Region: DUF3153; pfam11353
1091501004831	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1091501004832	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1091501004833	substrate binding pocket [chemical binding]; other site
1091501004834	chain length determination region; other site
1091501004835	substrate-Mg2+ binding site; other site
1091501004836	catalytic residues [active]
1091501004837	aspartate-rich region 1; other site
1091501004838	active site lid residues [active]
1091501004839	aspartate-rich region 2; other site
1091501004840	carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459
1091501004841	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1091501004842	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1091501004843	active site
1091501004844	ATP binding site [chemical binding]; other site
1091501004845	substrate binding site [chemical binding]; other site
1091501004846	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
1091501004847	substrate binding site [chemical binding]; other site
1091501004848	activation loop (A-loop); other site
1091501004849	activation loop (A-loop); other site
1091501004850	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
1091501004851	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
1091501004852	3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; COG3200
1091501004853	Protein of unknown function (DUF2029); Region: DUF2029; cl09812
1091501004854	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1091501004855	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1091501004856	putative acyl-acceptor binding pocket; other site
1091501004857	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
1091501004858	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
1091501004859	DTAP/Switch II; other site
1091501004860	Switch I; other site
1091501004861	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819
1091501004862	putative hydrophobic ligand binding site [chemical binding]; other site
1091501004863	potential frameshift: common BLAST hit: gi|253798749|ref|YP_003031750.1| long-chain fatty-acid-CoA ligase fadD15
1091501004864	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1091501004865	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1091501004866	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
1091501004867	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1091501004868	NlpC/P60 family; Region: NLPC_P60; pfam00877
1091501004869	potential frameshift: common BLAST hit: gi|340627197|ref|YP_004745649.1| putative anthranilate phosphoribosyltransferase TrpD
1091501004870	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386
1091501004871	Subunit I/III interface [polypeptide binding]; other site
1091501004872	potential frameshift: common BLAST hit: gi|340627199|ref|YP_004745651.1| putative ubiquinol-cytochrome C reductase QcrC
1091501004873	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
1091501004874	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
1091501004875	iron-sulfur cluster [ion binding]; other site
1091501004876	[2Fe-2S] cluster binding site [ion binding]; other site
1091501004877	potential frameshift: common BLAST hit: gi|340627201|ref|YP_004745653.1| putative ubiquinol-cytochrome C reductase QcrB
1091501004878	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
1091501004879	Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270
1091501004880	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
1091501004881	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
1091501004882	potential frameshift: common BLAST hit: gi|339632229|ref|YP_004723871.1| asparagine synthetase
1091501004883	potential frameshift: common BLAST hit: gi|339632229|ref|YP_004723871.1| asparagine synthetase
1091501004884	Ribokinase-like subgroup A.  Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942
1091501004885	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1091501004886	substrate binding site [chemical binding]; other site
1091501004887	ATP binding site [chemical binding]; other site
1091501004888	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
1091501004889	Glycerate kinase family; Region: Gly_kinase; cl00841
1091501004890	Protein of unknown function (DUF3043); Region: DUF3043; pfam11241
1091501004891	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cl11435
1091501004892	Cobalamin-5-phosphate synthase; Region: CobS; pfam02654
1091501004893	potential frameshift: common BLAST hit: gi|224990584|ref|YP_002645271.1| integral membrane protein
1091501004894	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
1091501004895	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
1091501004896	homodimer interface [polypeptide binding]; other site
1091501004897	substrate-cofactor binding pocket; other site
1091501004898	catalytic residue [active]
1091501004899	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
1091501004900	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
1091501004901	cyclase homology domain; Region: CHD; cd07302
1091501004902	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
1091501004903	nucleotidyl binding site; other site
1091501004904	metal binding site [ion binding]; metal-binding site
1091501004905	dimer interface [polypeptide binding]; other site
1091501004906	potential frameshift: common BLAST hit: gi|224990588|ref|YP_002645275.1| leucyl aminopeptidase
1091501004907	short chain dehydrogenase; Validated; Region: PRK05855
1091501004908	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1091501004909	classical (c) SDRs; Region: SDR_c; cd05233
1091501004910	NAD(P) binding site [chemical binding]; other site
1091501004911	active site
1091501004912	potential frameshift: common BLAST hit: gi|340627220|ref|YP_004745672.1| putative pyruvate dehydrogenase
1091501004913	atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242
1091501004914	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
1091501004915	putative NAD(P) binding site [chemical binding]; other site
1091501004916	putative active site [active]
1091501004917	lipoate-protein ligase B; Provisional; Region: PRK14345
1091501004918	lipoyl synthase; Provisional; Region: PRK05481
1091501004919	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1091501004920	FeS/SAM binding site; other site
1091501004921	Domain of unknown function (DUF4191); Region: DUF4191; pfam13829
1091501004922	RDD family; Region: RDD; pfam06271
1091501004923	glutamine synthetase, type I; Region: GlnA; TIGR00653
1091501004924	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
1091501004925	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
1091501004926	potential frameshift: common BLAST hit: gi|340627227|ref|YP_004745679.1| glutamate-ammonia-ligase adenylyltransferase GLNE
1091501004927	potential frameshift: common BLAST hit: gi|340627228|ref|YP_004745680.1| putative glutamine synthetase
1091501004928	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
1091501004929	TAP-like protein; Region: Abhydrolase_4; pfam08386
1091501004930	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
1091501004931	TAP-like protein; Region: Abhydrolase_4; pfam08386
1091501004932	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
1091501004933	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
1091501004934	oligomerization interface [polypeptide binding]; other site
1091501004935	active site
1091501004936	metal binding site [ion binding]; metal-binding site
1091501004937	CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374
1091501004938	putative active site; other site
1091501004939	putative metal binding residues [ion binding]; other site
1091501004940	signature motif; other site
1091501004941	putative triphosphate binding site [ion binding]; other site
1091501004942	The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880
1091501004943	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3826
1091501004944	potential frameshift: common BLAST hit: gi|253798706|ref|YP_003031707.1| bifunctional RNase H/acid phosphatase
1091501004945	Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
1091501004946	Putative zinc ribbon domain; Region: DUF164; pfam02591
1091501004947	hypothetical protein; Provisional; Region: PRK07908
1091501004948	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1091501004949	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1091501004950	homodimer interface [polypeptide binding]; other site
1091501004951	catalytic residue [active]
1091501004952	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
1091501004953	PIN domain nuclease, a component of toxin-antitoxin system (PIN domain) [Signal transduction mechanisms]; Region: COG3744
1091501004954	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
1091501004955	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1091501004956	active site
1091501004957	motif I; other site
1091501004958	motif II; other site
1091501004959	Low molecular weight phosphatase family; Region: LMWPc; cd00115
1091501004960	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
1091501004961	active site
1091501004962	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
1091501004963	cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209
1091501004964	potential frameshift: common BLAST hit: gi|340627242|ref|YP_004745694.1| putative peroxiredoxin AhpE
1091501004965	Protein of unknown function (DUF3052); Region: DUF3052; pfam11253
1091501004966	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
1091501004967	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
1091501004968	dimer interface [polypeptide binding]; other site
1091501004969	TPP-binding site [chemical binding]; other site
1091501004970	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
1091501004971	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
1091501004972	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
1091501004973	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
1091501004974	acyl carrier protein; Provisional; Region: acpP; PRK00982
1091501004975	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910
1091501004976	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
1091501004977	dimer interface [polypeptide binding]; other site
1091501004978	active site
1091501004979	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910
1091501004980	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
1091501004981	dimer interface [polypeptide binding]; other site
1091501004982	active site
1091501004983	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
1091501004984	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
1091501004985	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
1091501004986	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
1091501004987	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
1091501004988	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1091501004989	FAD binding domain; Region: FAD_binding_4; pfam01565
1091501004990	diacylglycerol kinase; Reviewed; Region: PRK11914
1091501004991	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
1091501004992	Protein of unknown function (DUF3145); Region: DUF3145; pfam11343
1091501004993	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1091501004994	Beta-lactamase; Region: Beta-lactamase; pfam00144
1091501004995	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1091501004996	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1091501004997	S-adenosylmethionine binding site [chemical binding]; other site
1091501004998	S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451
1091501004999	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
1091501005000	NAD binding site [chemical binding]; other site
1091501005001	catalytic Zn binding site [ion binding]; other site
1091501005002	substrate binding site [chemical binding]; other site
1091501005003	structural Zn binding site [ion binding]; other site
1091501005004	potential frameshift: common BLAST hit: gi|253798671|ref|YP_003031672.1| apolipoprotein N-acyltransferase
1091501005005	short chain dehydrogenase; Provisional; Region: PRK05854
1091501005006	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
1091501005007	putative NAD(P) binding site [chemical binding]; other site
1091501005008	active site
1091501005009	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1091501005010	nucleotide binding site [chemical binding]; other site
1091501005011	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1091501005012	potential frameshift: common BLAST hit: gi|340627272|ref|YP_004745724.1| putative cytochrome P450 124 CYP124
1091501005013	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
1091501005014	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1091501005015	Cytochrome P450; Region: p450; cl12078
1091501005016	Septum formation; Region: Septum_form; pfam13845
1091501005017	Protein of unknown function (DUF2695); Region: DUF2695; pfam10905
1091501005018	Predicted membrane protein [Function unknown]; Region: COG2149
1091501005019	Domain of unknown function (DUF202); Region: DUF202; pfam02656
1091501005020	potential frameshift: common BLAST hit: gi|253798656|ref|YP_003031657.1| cytochrome P450 121 cyp121
1091501005021	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial protein Rv2277c and similar proteins; Region: GDPD_Rv2277c_like; cd08580
1091501005022	Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009
1091501005023	putative active site [active]
1091501005024	catalytic site [active]
1091501005025	putative metal binding site [ion binding]; other site
1091501005026	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1091501005027	Transposase; Region: HTH_Tnp_1; cl17663
1091501005028	putative transposase OrfB; Reviewed; Region: PHA02517
1091501005029	HTH-like domain; Region: HTH_21; pfam13276
1091501005030	Integrase core domain; Region: rve; pfam00665
1091501005031	Integrase core domain; Region: rve_3; pfam13683
1091501005032	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
1091501005033	FAD binding domain; Region: FAD_binding_4; pfam01565
1091501005034	potential frameshift: common BLAST hit: gi|340627285|ref|YP_004745737.1| putative phosphate-transport permease PitB
1091501005035	potential frameshift: common BLAST hit: gi|339632304|ref|YP_004723946.1| LysR family transcriptional regulator
1091501005036	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1091501005037	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1091501005038	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1091501005039	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
1091501005040	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1091501005041	potential frameshift: common BLAST hit: gi|340627291|ref|YP_004745743.1| putative integral membrane transport protein YjcE
1091501005042	CDP-diacylglycerol pyrophosphatase [Lipid metabolism]; Region: Cdh; COG2134
1091501005043	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
1091501005044	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
1091501005045	active site residue [active]
1091501005046	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
1091501005047	active site residue [active]
1091501005048	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
1091501005049	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
1091501005050	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1091501005051	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1091501005052	homodimer interface [polypeptide binding]; other site
1091501005053	catalytic residue [active]
1091501005054	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3196
1091501005055	haloalkane dehalogenase; Provisional; Region: PRK00870
1091501005056	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1091501005057	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1091501005058	active site
1091501005059	catalytic tetrad [active]
1091501005060	heat shock protein 90; Provisional; Region: PRK05218
1091501005061	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1091501005062	ATP binding site [chemical binding]; other site
1091501005063	Mg2+ binding site [ion binding]; other site
1091501005064	G-X-G motif; other site
1091501005065	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
1091501005066	Cutinase; Region: Cutinase; pfam01083
1091501005067	Domain of unknown function (DUF1918); Region: DUF1918; pfam08940
1091501005068	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159
1091501005069	Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908
1091501005070	Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908
1091501005071	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1091501005072	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
1091501005073	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1091501005074	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
1091501005075	Uncharacterized conserved protein [Function unknown]; Region: COG2442
1091501005076	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
1091501005077	DNA binding residues [nucleotide binding]
1091501005078	Family description; Region: UvrD_C_2; pfam13538
1091501005079	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
1091501005080	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1091501005081	ABC-ATPase subunit interface; other site
1091501005082	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1091501005083	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1091501005084	dimer interface [polypeptide binding]; other site
1091501005085	conserved gate region; other site
1091501005086	putative PBP binding loops; other site
1091501005087	ABC-ATPase subunit interface; other site
1091501005088	potential frameshift: common BLAST hit: gi|339632343|ref|YP_004723985.1| sugar ABC transporter permease
1091501005089	amino acid transporter; Region: 2A0306; TIGR00909
1091501005090	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
1091501005091	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1091501005092	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1091501005093	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1091501005094	Amidinotransferase; Region: Amidinotransf; pfam02274
1091501005095	N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834
1091501005096	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
1091501005097	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
1091501005098	putative DNA binding site [nucleotide binding]; other site
1091501005099	putative Zn2+ binding site [ion binding]; other site
1091501005100	AsnC family; Region: AsnC_trans_reg; pfam01037
1091501005101	potential frameshift: common BLAST hit: gi|339632351|ref|YP_004723993.1| ABC transporter ATP-binding protein
1091501005102	MarR family; Region: MarR; pfam01047
1091501005103	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1091501005104	PE family; Region: PE; pfam00934
1091501005105	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
1091501005106	LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041
1091501005107	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1091501005108	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
1091501005109	Malic enzyme, N-terminal domain; Region: malic; pfam00390
1091501005110	NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312
1091501005111	NAD(P) binding site [chemical binding]; other site
1091501005112	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1091501005113	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1091501005114	putative substrate translocation pore; other site
1091501005115	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1091501005116	putative substrate translocation pore; other site
1091501005117	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1091501005118	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1091501005119	dimer interface [polypeptide binding]; other site
1091501005120	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1091501005121	catalytic residue [active]
1091501005122	Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762
1091501005123	serine O-acetyltransferase; Region: cysE; TIGR01172
1091501005124	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
1091501005125	trimer interface [polypeptide binding]; other site
1091501005126	active site
1091501005127	substrate binding site [chemical binding]; other site
1091501005128	CoA binding site [chemical binding]; other site
1091501005129	hypothetical protein; Provisional; Region: PRK14851
1091501005130	hypothetical protein; Validated; Region: PRK08223
1091501005131	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483
1091501005132	ATP binding site [chemical binding]; other site
1091501005133	substrate interface [chemical binding]; other site
1091501005134	potential frameshift: common BLAST hit: gi|340627350|ref|YP_004745802.1| putative transmembrane transport protein MMPL9
1091501005135	PE family; Region: PE; pfam00934
1091501005136	potential frameshift: common BLAST hit: gi|339632368|ref|YP_004724010.1| DNA primase
1091501005137	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007
1091501005138	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1091501005139	Zn2+ binding site [ion binding]; other site
1091501005140	Mg2+ binding site [ion binding]; other site
1091501005141	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
1091501005142	Repair protein; Region: Repair_PSII; pfam04536
1091501005143	Proteins of 100 residues with WXG; Region: WXG100; pfam06013
1091501005144	WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930
1091501005145	Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511
1091501005146	Phosphoesterase family; Region: Phosphoesterase; pfam04185
1091501005147	Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511
1091501005148	Phosphoesterase family; Region: Phosphoesterase; pfam04185
1091501005149	Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511
1091501005150	Phosphoesterase family; Region: Phosphoesterase; pfam04185
1091501005151	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1091501005152	PPE family; Region: PPE; pfam00823
1091501005153	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1091501005154	Transposase; Region: HTH_Tnp_1; cl17663
1091501005155	putative transposase OrfB; Reviewed; Region: PHA02517
1091501005156	HTH-like domain; Region: HTH_21; pfam13276
1091501005157	Integrase core domain; Region: rve; pfam00665
1091501005158	Integrase core domain; Region: rve_3; pfam13683
1091501005159	PPE family; Region: PPE; pfam00823
1091501005160	PPE family; Region: PPE; pfam00823
1091501005161	glycyl-tRNA synthetase; Provisional; Region: PRK04173
1091501005162	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1091501005163	motif 1; other site
1091501005164	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774
1091501005165	active site
1091501005166	motif 2; other site
1091501005167	motif 3; other site
1091501005168	GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
1091501005169	anticodon binding site; other site
1091501005170	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1091501005171	dimerization interface [polypeptide binding]; other site
1091501005172	putative DNA binding site [nucleotide binding]; other site
1091501005173	putative Zn2+ binding site [ion binding]; other site
1091501005174	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1091501005175	metal binding site 2 [ion binding]; metal-binding site
1091501005176	putative DNA binding helix; other site
1091501005177	metal binding site 1 [ion binding]; metal-binding site
1091501005178	dimer interface [polypeptide binding]; other site
1091501005179	structural Zn2+ binding site [ion binding]; other site
1091501005180	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
1091501005181	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
1091501005182	catalytic residue [active]
1091501005183	putative FPP diphosphate  binding site; other site
1091501005184	putative FPP binding hydrophobic cleft; other site
1091501005185	dimer interface [polypeptide binding]; other site
1091501005186	putative IPP diphosphate binding site; other site
1091501005187	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
1091501005188	Recombination protein O N terminal; Region: RecO_N; pfam11967
1091501005189	Recombination protein O C terminal; Region: RecO_C; pfam02565
1091501005190	potential frameshift: common BLAST hit: gi|340627374|ref|YP_004745826.1| putative amidase AMIA2
1091501005191	potential frameshift: common BLAST hit: gi|340627375|ref|YP_004745827.1| putative GTP-binding protein ERA
1091501005192	potential frameshift: common BLAST hit: gi|224990739|ref|YP_002645426.1| transmembrane protein
1091501005193	potential frameshift: common BLAST hit: gi|253798555|ref|YP_003031556.1| metalloprotease
1091501005194	K homology RNA-binding domain; Region: KH; smart00322
1091501005195	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
1091501005196	PhoH-like protein; Region: PhoH; pfam02562
1091501005197	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
1091501005198	PE family; Region: PE; pfam00934
1091501005199	RNA methyltransferase; Region: Methyltrans_RNA; cl00611
1091501005200	RNA methyltransferase, RsmE family; Region: TIGR00046
1091501005201	chaperone protein DnaJ; Provisional; Region: PRK14278
1091501005202	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1091501005203	HSP70 interaction site [polypeptide binding]; other site
1091501005204	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
1091501005205	Zn binding sites [ion binding]; other site
1091501005206	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
1091501005207	dimer interface [polypeptide binding]; other site
1091501005208	HrcA protein C terminal domain; Region: HrcA; pfam01628
1091501005209	Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450
1091501005210	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251
1091501005211	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1091501005212	Condensation domain; Region: Condensation; pfam00668
1091501005213	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1091501005214	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1091501005215	acyl-activating enzyme (AAE) consensus motif; other site
1091501005216	AMP binding site [chemical binding]; other site
1091501005217	Condensation domain; Region: Condensation; pfam00668
1091501005218	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
1091501005219	potential frameshift: common BLAST hit: gi|345462009|ref|NP_216896.2| peptide synthetase
1091501005220	potential frameshift: common BLAST hit: gi|339632407|ref|YP_004724049.1| polyketide synthetase
1091501005221	potential frameshift: common BLAST hit: gi|15841894|ref|NP_336931.1| polyketide synthase
1091501005222	potential frameshift: common BLAST hit: gi|253798540|ref|YP_003031541.1| phenyloxazoline synthase mbtB
1091501005223	potential frameshift: common BLAST hit: gi|339632409|ref|YP_004724051.1| phenyloxazoline synthase
1091501005224	potential frameshift: common BLAST hit: gi|339632410|ref|YP_004724052.1| bifunctional enzyme MBTA: salicyl-AMP ligase (SAL-AMP ligase) +
1091501005225	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
1091501005226	potential frameshift: common BLAST hit: gi|339632412|ref|YP_004724054.1| isochorismate synthase
1091501005227	Predicted permease [General function prediction only]; Region: COG3329
1091501005228	coproporphyrinogen III oxidase; Validated; Region: PRK05628
1091501005229	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
1091501005230	potential frameshift: common BLAST hit: gi|340627400|ref|YP_004745852.1| putative ferredoxin-dependent nitrite reductase NIRA
1091501005231	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
1091501005232	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
1091501005233	Active Sites [active]
1091501005234	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
1091501005235	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
1091501005236	putative active site [active]
1091501005237	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414
1091501005238	putative active site [active]
1091501005239	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040
1091501005240	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040
1091501005241	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040
1091501005242	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
1091501005243	OPT oligopeptide transporter protein; Region: OPT; cl14607
1091501005244	OPT oligopeptide transporter protein; Region: OPT; cl14607
1091501005245	PE family; Region: PE; pfam00934
1091501005246	potential frameshift: common BLAST hit: gi|15841913|ref|NP_336950.1| sulfate ABC transporter ATP-binding protein
1091501005247	sulfate transport protein; Provisional; Region: cysT; CHL00187
1091501005248	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1091501005249	dimer interface [polypeptide binding]; other site
1091501005250	conserved gate region; other site
1091501005251	putative PBP binding loops; other site
1091501005252	ABC-ATPase subunit interface; other site
1091501005253	sulfate transport protein; Provisional; Region: cysT; CHL00187
1091501005254	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1091501005255	dimer interface [polypeptide binding]; other site
1091501005256	conserved gate region; other site
1091501005257	putative PBP binding loops; other site
1091501005258	ABC-ATPase subunit interface; other site
1091501005259	ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613
1091501005260	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
1091501005261	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
1091501005262	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
1091501005263	PknH-like extracellular domain; Region: PknH_C; pfam14032
1091501005264	GTP-binding protein LepA; Provisional; Region: PRK05433
1091501005265	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
1091501005266	G1 box; other site
1091501005267	putative GEF interaction site [polypeptide binding]; other site
1091501005268	GTP/Mg2+ binding site [chemical binding]; other site
1091501005269	Switch I region; other site
1091501005270	G2 box; other site
1091501005271	G3 box; other site
1091501005272	Switch II region; other site
1091501005273	G4 box; other site
1091501005274	G5 box; other site
1091501005275	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
1091501005276	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
1091501005277	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
1091501005278	PemK-like protein; Region: PemK; pfam02452
1091501005279	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623
1091501005280	FOG: CBS domain [General function prediction only]; Region: COG0517
1091501005281	ribonuclease Z; Reviewed; Region: PRK00055
1091501005282	PE family; Region: PE; pfam00934
1091501005283	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
1091501005284	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
1091501005285	Uncharacterized conserved protein [Function unknown]; Region: COG2308
1091501005286	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
1091501005287	hypothetical protein; Reviewed; Region: PRK07914
1091501005288	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
1091501005289	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
1091501005290	Helix-hairpin-helix motif; Region: HHH; pfam00633
1091501005291	potential frameshift: common BLAST hit: gi|339632443|ref|YP_004724085.1| enhanced intracellular survival protein EIS
1091501005292	Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307
1091501005293	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
1091501005294	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
1091501005295	active site
1091501005296	catalytic triad [active]
1091501005297	oxyanion hole [active]
1091501005298	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1091501005299	catalytic core [active]
1091501005300	Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799
1091501005301	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
1091501005302	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
1091501005303	active site
1091501005304	(T/H)XGH motif; other site
1091501005305	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1091501005306	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1091501005307	S-adenosylmethionine binding site [chemical binding]; other site
1091501005308	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
1091501005309	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
1091501005310	Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552
1091501005311	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
1091501005312	metal ion-dependent adhesion site (MIDAS); other site
1091501005313	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1091501005314	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1091501005315	Walker A motif; other site
1091501005316	ATP binding site [chemical binding]; other site
1091501005317	Walker B motif; other site
1091501005318	arginine finger; other site
1091501005319	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
1091501005320	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
1091501005321	putative catalytic cysteine [active]
1091501005322	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1091501005323	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
1091501005324	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
1091501005325	dimer interface [polypeptide binding]; other site
1091501005326	decamer (pentamer of dimers) interface [polypeptide binding]; other site
1091501005327	catalytic triad [active]
1091501005328	peroxidatic and resolving cysteines [active]
1091501005329	alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777
1091501005330	alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778
1091501005331	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1091501005332	PPE family; Region: PPE; pfam00823
1091501005333	PE family; Region: PE; pfam00934
1091501005334	potential frameshift: common BLAST hit: gi|224990810|ref|YP_002645497.1| transmembrane protein
1091501005335	potential frameshift: common BLAST hit: gi|340627448|ref|YP_004745900.1| putative cyclase
1091501005336	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1091501005337	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
1091501005338	substrate binding site [chemical binding]; other site
1091501005339	dimer interface [polypeptide binding]; other site
1091501005340	ATP binding site [chemical binding]; other site
1091501005341	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
1091501005342	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
1091501005343	Predicted amidohydrolase [General function prediction only]; Region: COG0388
1091501005344	active site
1091501005345	catalytic triad [active]
1091501005346	dimer interface [polypeptide binding]; other site
1091501005347	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
1091501005348	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
1091501005349	homodimer interface [polypeptide binding]; other site
1091501005350	NAD binding pocket [chemical binding]; other site
1091501005351	ATP binding pocket [chemical binding]; other site
1091501005352	Mg binding site [ion binding]; other site
1091501005353	active-site loop [active]
1091501005354	gamma-glutamyl kinase; Provisional; Region: PRK05429
1091501005355	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
1091501005356	nucleotide binding site [chemical binding]; other site
1091501005357	homotetrameric interface [polypeptide binding]; other site
1091501005358	putative phosphate binding site [ion binding]; other site
1091501005359	putative allosteric binding site; other site
1091501005360	PUA domain; Region: PUA; pfam01472
1091501005361	GTPase CgtA; Reviewed; Region: obgE; PRK12296
1091501005362	GTP1/OBG; Region: GTP1_OBG; pfam01018
1091501005363	Obg GTPase; Region: Obg; cd01898
1091501005364	G1 box; other site
1091501005365	GTP/Mg2+ binding site [chemical binding]; other site
1091501005366	Switch I region; other site
1091501005367	G2 box; other site
1091501005368	G3 box; other site
1091501005369	Switch II region; other site
1091501005370	G4 box; other site
1091501005371	G5 box; other site
1091501005372	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
1091501005373	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
1091501005374	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
1091501005375	potential frameshift: common BLAST hit: gi|339632471|ref|YP_004724113.1| C4-dicarboxylate-transporter
1091501005376	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
1091501005377	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
1091501005378	homodimer interface [polypeptide binding]; other site
1091501005379	oligonucleotide binding site [chemical binding]; other site
1091501005380	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
1091501005381	active site
1091501005382	multimer interface [polypeptide binding]; other site
1091501005383	Protein of unknown function (DUF4233); Region: DUF4233; pfam14017
1091501005384	potential frameshift: common BLAST hit: gi|339632475|ref|YP_004724117.1| folylpolyglutamate synthase
1091501005385	potential frameshift: common BLAST hit: gi|253798472|ref|YP_003031473.1| valyl-tRNA synthetase
1091501005386	potential frameshift: common BLAST hit: gi|253798472|ref|YP_003031473.1| valyl-tRNA synthetase
1091501005387	Uncharacterized conserved protein [Function unknown]; Region: COG3268
1091501005388	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
1091501005389	NAD(P) binding pocket [chemical binding]; other site
1091501005390	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
1091501005391	potential frameshift: common BLAST hit: gi|340627467|ref|YP_004745919.1| putative molybdopterin-guanine dinucleotide biosynthesis protein A
1091501005392	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867
1091501005393	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
1091501005394	TPP-binding site [chemical binding]; other site
1091501005395	potential frameshift: common BLAST hit: gi|253798466|ref|YP_003031467.1| oxidoreductase alpha subunit
1091501005396	potential frameshift: common BLAST hit: gi|253798466|ref|YP_003031467.1| oxidoreductase alpha subunit
1091501005397	potential frameshift: common BLAST hit: gi|15841981|ref|NP_337018.1| ATP-dependent protease ATP-binding subunit ClpX
1091501005398	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
1091501005399	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
1091501005400	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1091501005401	Walker A motif; other site
1091501005402	ATP binding site [chemical binding]; other site
1091501005403	Walker B motif; other site
1091501005404	homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485
1091501005405	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
1091501005406	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1091501005407	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1091501005408	putative substrate translocation pore; other site
1091501005409	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1091501005410	potential frameshift: common BLAST hit: gi|339632488|ref|YP_004724130.1| ATP-dependent CLP protease proteolytic subunit 2
1091501005411	Clp protease; Region: CLP_protease; pfam00574
1091501005412	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
1091501005413	oligomer interface [polypeptide binding]; other site
1091501005414	active site residues [active]
1091501005415	trigger factor; Provisional; Region: tig; PRK01490
1091501005416	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1091501005417	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
1091501005418	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1091501005419	Beta-lactamase; Region: Beta-lactamase; pfam00144
1091501005420	N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: FpgNei_N; cl03119
1091501005421	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
1091501005422	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
1091501005423	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1091501005424	ribose-5-phosphate isomerase B; Provisional; Region: PRK05571
1091501005425	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
1091501005426	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1091501005427	potential frameshift: common BLAST hit: gi|340627481|ref|YP_004745933.1| putative aminopeptidase N
1091501005428	potential frameshift: common BLAST hit: gi|340627481|ref|YP_004745933.1| putative aminopeptidase N
1091501005429	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
1091501005430	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1091501005431	active site
1091501005432	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
1091501005433	apolar tunnel; other site
1091501005434	heme binding site [chemical binding]; other site
1091501005435	dimerization interface [polypeptide binding]; other site
1091501005436	potential frameshift: common BLAST hit: gi|224990848|ref|YP_002645535.1| alpha-glucosidase
1091501005437	potential frameshift: common BLAST hit: gi|224990848|ref|YP_002645535.1| alpha-glucosidase
1091501005438	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1091501005439	active site
1091501005440	potential frameshift: common BLAST hit: gi|253798445|ref|YP_003031446.1| NAD-dependent glutamate dehydrogenase gdh
1091501005441	potential frameshift: common BLAST hit: gi|340627491|ref|YP_004745943.1| putative macrolide-transport ATP-binding protein ABC transporter
1091501005442	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
1091501005443	dimer interface [polypeptide binding]; other site
1091501005444	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
1091501005445	ssDNA binding site [nucleotide binding]; other site
1091501005446	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1091501005447	putative transposase OrfB; Reviewed; Region: PHA02517
1091501005448	HTH-like domain; Region: HTH_21; pfam13276
1091501005449	Integrase core domain; Region: rve; pfam00665
1091501005450	Integrase core domain; Region: rve_3; pfam13683
1091501005451	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1091501005452	Transposase; Region: HTH_Tnp_1; cl17663
1091501005453	glycerol-3-phosphate acyltransferase; Validated; Region: PRK03355
1091501005454	glycerol-3-phosphate acyltransferase; Validated; Region: PRK03355
1091501005455	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993
1091501005456	putative acyl-acceptor binding pocket; other site
1091501005457	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1091501005458	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1091501005459	putative acyl-acceptor binding pocket; other site
1091501005460	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
1091501005461	HAD-superfamily subfamily IB hydrolase, TIGR01490; Region: HAD-SF-IB-hyp1
1091501005462	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
1091501005463	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
1091501005464	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
1091501005465	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1091501005466	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1091501005467	enoyl-CoA hydratase; Provisional; Region: PRK05870
1091501005468	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1091501005469	substrate binding site [chemical binding]; other site
1091501005470	oxyanion hole (OAH) forming residues; other site
1091501005471	trimer interface [polypeptide binding]; other site
1091501005472	PE family; Region: PE; pfam00934
1091501005473	potential frameshift: common BLAST hit: gi|148823685|ref|YP_001288439.1| LuxR family transcriptional regulator
1091501005474	potential frameshift: common BLAST hit: gi|15842015|ref|NP_337052.1| LuxR family transcriptional regulator
1091501005475	potential frameshift: common BLAST hit: gi|15842017|ref|NP_337054.1| PE PGRS family protein
1091501005476	thymidylate synthase; Provisional; Region: thyA; PRK00956
1091501005477	Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028
1091501005478	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
1091501005479	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1091501005480	E3 interaction surface; other site
1091501005481	lipoyl attachment site [posttranslational modification]; other site
1091501005482	e3 binding domain; Region: E3_binding; pfam02817
1091501005483	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1091501005484	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
1091501005485	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
1091501005486	alpha subunit interface [polypeptide binding]; other site
1091501005487	TPP binding site [chemical binding]; other site
1091501005488	heterodimer interface [polypeptide binding]; other site
1091501005489	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1091501005490	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
1091501005491	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
1091501005492	tetramer interface [polypeptide binding]; other site
1091501005493	TPP-binding site [chemical binding]; other site
1091501005494	heterodimer interface [polypeptide binding]; other site
1091501005495	phosphorylation loop region [posttranslational modification]
1091501005496	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
1091501005497	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
1091501005498	putative active site [active]
1091501005499	putative catalytic site [active]
1091501005500	potential frameshift: common BLAST hit: gi|340627514|ref|YP_004745966.1| putative acyl-CoA dehydrogenase FADE19 (MMGC)
1091501005501	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
1091501005502	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1091501005503	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1091501005504	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1091501005505	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1091501005506	carboxyltransferase (CT) interaction site; other site
1091501005507	biotinylation site [posttranslational modification]; other site
1091501005508	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
1091501005509	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
1091501005510	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
1091501005511	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
1091501005512	potential frameshift: common BLAST hit: gi|340627518|ref|YP_004745970.1| putative succinyl-CoA:3-ketoacid-coenzyme A transferase alpha
1091501005513	potential frameshift: common BLAST hit: gi|340627519|ref|YP_004745971.1| putative fatty-acid-CoA ligase FADD35
1091501005514	potential frameshift: common BLAST hit: gi|340627519|ref|YP_004745971.1| putative fatty-acid-CoA ligase FADD35
1091501005515	potential frameshift: common BLAST hit: gi|340627519|ref|YP_004745971.1| putative fatty-acid-CoA ligase FADD35
1091501005516	potential frameshift: common BLAST hit: gi|340627519|ref|YP_004745971.1| putative fatty-acid-CoA ligase FADD35
1091501005517	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1091501005518	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1091501005519	potential frameshift: common BLAST hit: gi|340627522|ref|YP_004745974.1| putative integral membrane leucine and alanine rich protein
1091501005520	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
1091501005521	classical (c) SDRs; Region: SDR_c; cd05233
1091501005522	NAD(P) binding site [chemical binding]; other site
1091501005523	active site
1091501005524	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
1091501005525	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
1091501005526	catalytic site [active]
1091501005527	putative active site [active]
1091501005528	putative substrate binding site [chemical binding]; other site
1091501005529	dimer interface [polypeptide binding]; other site
1091501005530	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1091501005531	MULE transposase domain; Region: MULE; pfam10551
1091501005532	Domain of unknown function (DUF4411); Region: DUF4411; pfam14367
1091501005533	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1091501005534	non-specific DNA binding site [nucleotide binding]; other site
1091501005535	salt bridge; other site
1091501005536	sequence-specific DNA binding site [nucleotide binding]; other site
1091501005537	Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856
1091501005538	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2739; cl17893
1091501005539	potential frameshift: common BLAST hit: gi|224990895|ref|YP_002645582.1| lipoprotein
1091501005540	PE family; Region: PE; pfam00934
1091501005541	Protein of unknown function (DUF3618); Region: DUF3618; pfam12277
1091501005542	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
1091501005543	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
1091501005544	catalytic triad [active]
1091501005545	hypothetical protein; Provisional; Region: PRK07907
1091501005546	M20 Dipeptidases; Region: M20_Dipept_like; cd03893
1091501005547	active site
1091501005548	metal binding site [ion binding]; metal-binding site
1091501005549	dimer interface [polypeptide binding]; other site
1091501005550	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
1091501005551	potential frameshift: common BLAST hit: gi|340627539|ref|YP_004745991.1| putative fatty acid synthase
1091501005552	potential frameshift: common BLAST hit: gi|340627539|ref|YP_004745991.1| putative fatty acid synthase
1091501005553	potential frameshift: common BLAST hit: gi|340627539|ref|YP_004745991.1| putative fatty acid synthase
1091501005554	potential frameshift: common BLAST hit: gi|224990901|ref|YP_002645588.1| fatty acid synthase
1091501005555	potential frameshift: common BLAST hit: gi|253798397|ref|YP_003031398.1| fatty-acid synthase fas
1091501005556	Domain of unknown function (DUF1906); Region: DUF1906; pfam08924
1091501005557	PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882
1091501005558	putative active site [active]
1091501005559	Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715
1091501005560	Mrr N-terminal domain; Region: Mrr_N; pfam14338
1091501005561	Restriction endonuclease; Region: Mrr_cat; pfam04471
1091501005562	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
1091501005563	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
1091501005564	ERCC4 domain; Region: ERCC4; pfam02732
1091501005565	Lsr2; Region: Lsr2; pfam11774
1091501005566	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
1091501005567	putative active site [active]
1091501005568	potential frameshift: common BLAST hit: gi|340627547|ref|YP_004745999.1| putative amino acid decarboxylase
1091501005569	potential frameshift: common BLAST hit: gi|340627547|ref|YP_004745999.1| putative amino acid decarboxylase
1091501005570	potential frameshift: common BLAST hit: gi|339632558|ref|YP_004724200.1| amino acid decarboxylase
1091501005571	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
1091501005572	elongation factor P; Validated; Region: PRK00529
1091501005573	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
1091501005574	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
1091501005575	RNA binding site [nucleotide binding]; other site
1091501005576	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
1091501005577	RNA binding site [nucleotide binding]; other site
1091501005578	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1091501005579	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1091501005580	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
1091501005581	active site
1091501005582	potential frameshift: common BLAST hit: gi|224990914|ref|YP_002645601.1| transmembrane protein
1091501005583	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
1091501005584	Dehydroquinase class II; Region: DHquinase_II; pfam01220
1091501005585	trimer interface [polypeptide binding]; other site
1091501005586	active site
1091501005587	dimer interface [polypeptide binding]; other site
1091501005588	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
1091501005589	active site
1091501005590	dimer interface [polypeptide binding]; other site
1091501005591	metal binding site [ion binding]; metal-binding site
1091501005592	shikimate kinase; Reviewed; Region: aroK; PRK00131
1091501005593	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
1091501005594	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
1091501005595	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
1091501005596	Tetramer interface [polypeptide binding]; other site
1091501005597	active site
1091501005598	FMN-binding site [chemical binding]; other site
1091501005599	Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259
1091501005600	digalactosyldiacylglycerol synthase; Region: PLN02846
1091501005601	Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450
1091501005602	PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882
1091501005603	putative active site [active]
1091501005604	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
1091501005605	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
1091501005606	oligomeric interface; other site
1091501005607	putative active site [active]
1091501005608	homodimer interface [polypeptide binding]; other site
1091501005609	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2402
1091501005610	putative active site [active]
1091501005611	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
1091501005612	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
1091501005613	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
1091501005614	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
1091501005615	NAD(P) binding site [chemical binding]; other site
1091501005616	shikimate binding site; other site
1091501005617	Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559
1091501005618	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
1091501005619	dimerization interface [polypeptide binding]; other site
1091501005620	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
1091501005621	DHHA1 domain; Region: DHHA1; pfam02272
1091501005622	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
1091501005623	tRNA synthetases class II (A); Region: tRNA-synt_2c; pfam01411
1091501005624	motif 1; other site
1091501005625	active site
1091501005626	motif 2; other site
1091501005627	motif 3; other site
1091501005628	alanine-tRNA ligase; Region: PLN02961
1091501005629	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
1091501005630	Uncharacterized protein family UPF0047; Region: UPF0047; cl00439
1091501005631	recombination factor protein RarA; Reviewed; Region: PRK13342
1091501005632	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1091501005633	Walker A motif; other site
1091501005634	ATP binding site [chemical binding]; other site
1091501005635	Walker B motif; other site
1091501005636	arginine finger; other site
1091501005637	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
1091501005638	potential frameshift: common BLAST hit: gi|340627577|ref|YP_004746029.1| putative proline and glycine rich transmembrane protein
1091501005639	Protein of unknown function (DUF2652); Region: DUF2652; pfam10851
1091501005640	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1091501005641	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1091501005642	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1091501005643	Walker A/P-loop; other site
1091501005644	ATP binding site [chemical binding]; other site
1091501005645	Q-loop/lid; other site
1091501005646	ABC transporter signature motif; other site
1091501005647	Walker B; other site
1091501005648	D-loop; other site
1091501005649	H-loop/switch region; other site
1091501005650	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1091501005651	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1091501005652	ligand binding site [chemical binding]; other site
1091501005653	flexible hinge region; other site
1091501005654	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1091501005655	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1091501005656	ligand binding site [chemical binding]; other site
1091501005657	flexible hinge region; other site
1091501005658	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
1091501005659	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
1091501005660	active site
1091501005661	nucleophile elbow; other site
1091501005662	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
1091501005663	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
1091501005664	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
1091501005665	Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899
1091501005666	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196
1091501005667	Uncharacterized conserved protein [Function unknown]; Region: COG2308
1091501005668	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
1091501005669	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
1091501005670	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307
1091501005671	Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005
1091501005672	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
1091501005673	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
1091501005674	Transglutaminase/protease-like homologues; Region: TGc; smart00460
1091501005675	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3801
1091501005676	Predicted membrane protein [Function unknown]; Region: COG4129
1091501005677	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
1091501005678	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
1091501005679	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
1091501005680	dimer interface [polypeptide binding]; other site
1091501005681	anticodon binding site; other site
1091501005682	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
1091501005683	homodimer interface [polypeptide binding]; other site
1091501005684	motif 1; other site
1091501005685	active site
1091501005686	motif 2; other site
1091501005687	GAD domain; Region: GAD; pfam02938
1091501005688	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1091501005689	active site
1091501005690	motif 3; other site
1091501005691	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
1091501005692	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
1091501005693	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
1091501005694	putative hydrophobic ligand binding site [chemical binding]; other site
1091501005695	protein interface [polypeptide binding]; other site
1091501005696	gate; other site
1091501005697	Predicted metalloprotease [General function prediction only]; Region: COG2321
1091501005698	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
1091501005699	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
1091501005700	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1091501005701	active site
1091501005702	metal binding site [ion binding]; metal-binding site
1091501005703	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
1091501005704	haloalkane dehalogenase; Provisional; Region: PRK03592
1091501005705	potential frameshift: common BLAST hit: gi|340627597|ref|YP_004746049.1| putative histidyl-tRNA synthetase
1091501005706	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
1091501005707	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
1091501005708	active site
1091501005709	potential frameshift: common BLAST hit: gi|253798336|ref|YP_003031337.1| GTP pyrophosphokinase
1091501005710	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1091501005711	active site
1091501005712	potential frameshift: common BLAST hit: gi|253798334|ref|YP_003031335.1| lipoprotein
1091501005713	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
1091501005714	Protein export membrane protein; Region: SecD_SecF; pfam02355
1091501005715	potential frameshift: common BLAST hit: gi|340627604|ref|YP_004746056.1| putative protein-export membrane protein SECD
1091501005716	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05886
1091501005717	4-aminobutyrate aminotransferase; Provisional; Region: PRK06058
1091501005718	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1091501005719	inhibitor-cofactor binding pocket; inhibition site
1091501005720	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1091501005721	catalytic residue [active]
1091501005722	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
1091501005723	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1091501005724	acyl-activating enzyme (AAE) consensus motif; other site
1091501005725	AMP binding site [chemical binding]; other site
1091501005726	active site
1091501005727	CoA binding site [chemical binding]; other site
1091501005728	Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320
1091501005729	extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235
1091501005730	putative NAD(P) binding site [chemical binding]; other site
1091501005731	active site
1091501005732	putative substrate binding site [chemical binding]; other site
1091501005733	PE family; Region: PE; pfam00934
1091501005734	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
1091501005735	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1091501005736	Walker A motif; other site
1091501005737	ATP binding site [chemical binding]; other site
1091501005738	Walker B motif; other site
1091501005739	arginine finger; other site
1091501005740	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
1091501005741	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
1091501005742	RuvA N terminal domain; Region: RuvA_N; pfam01330
1091501005743	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
1091501005744	active site
1091501005745	putative DNA-binding cleft [nucleotide binding]; other site
1091501005746	dimer interface [polypeptide binding]; other site
1091501005747	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
1091501005748	looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439
1091501005749	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
1091501005750	putative active site [active]
1091501005751	Domain of unknown function (DUF4178); Region: DUF4178; pfam13785
1091501005752	Protein of unknown function DUF2617; Region: DUF2617; pfam10936
1091501005753	Domain of unknown function (DUF4247); Region: DUF4247; pfam14042
1091501005754	potential frameshift: common BLAST hit: gi|148823794|ref|YP_001288548.1| integral membrane protein
1091501005755	Predicted spermidine synthase with an N-terminal membrane domain [General function prediction only]; Region: COG4262
1091501005756	Spermine/spermidine synthase; Region: Spermine_synth; pfam01564
1091501005757	Plasmid stability protein [General function prediction only]; Region: StbC; COG4691
1091501005758	potential frameshift: common BLAST hit: gi|253798315|ref|YP_003031316.1| toxin
1091501005759	Transcriptional regulator; Region: Transcrip_reg; cl00361
1091501005760	hypothetical protein; Validated; Region: PRK00110
1091501005761	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
1091501005762	predicted active site [active]
1091501005763	catalytic triad [active]
1091501005764	potential frameshift: common BLAST hit: gi|340627623|ref|YP_004746075.1| putative acyl-CoA thioesterase II TESB2 (TEII)
1091501005765	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
1091501005766	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
1091501005767	active site
1091501005768	multimer interface [polypeptide binding]; other site
1091501005769	pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679
1091501005770	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
1091501005771	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
1091501005772	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1091501005773	PPE family; Region: PPE; pfam00823
1091501005774	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1091501005775	PE-PPE domain; Region: PE-PPE; pfam08237
1091501005776	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_26; cd04685
1091501005777	nudix motif; other site
1091501005778	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1091501005779	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1091501005780	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
1091501005781	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
1091501005782	putative acyl-acceptor binding pocket; other site
1091501005783	FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275
1091501005784	nucleotide binding site/active site [active]
1091501005785	HIT family signature motif; other site
1091501005786	catalytic residue [active]
1091501005787	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305
1091501005788	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
1091501005789	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
1091501005790	active site
1091501005791	dimer interface [polypeptide binding]; other site
1091501005792	motif 1; other site
1091501005793	motif 2; other site
1091501005794	motif 3; other site
1091501005795	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
1091501005796	anticodon binding site; other site
1091501005797	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1091501005798	phosphate binding site [ion binding]; other site
1091501005799	PE family; Region: PE; pfam00934
1091501005800	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4762
1091501005801	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
1091501005802	Predicted transcriptional regulator [Transcription]; Region: COG2345
1091501005803	Helix-turn-helix domain; Region: HTH_20; pfam12840
1091501005804	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1091501005805	S-adenosylmethionine binding site [chemical binding]; other site
1091501005806	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1091501005807	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1091501005808	Ligand Binding Site [chemical binding]; other site
1091501005809	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1091501005810	Ligand Binding Site [chemical binding]; other site
1091501005811	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1091501005812	Ligand Binding Site [chemical binding]; other site
1091501005813	Universal stress protein family; Region: Usp; pfam00582
1091501005814	Ligand Binding Site [chemical binding]; other site
1091501005815	SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164
1091501005816	active site
1091501005817	Peptidase family M50; Region: Peptidase_M50; pfam02163
1091501005818	putative substrate binding region [chemical binding]; other site
1091501005819	FOG: CBS domain [General function prediction only]; Region: COG0517
1091501005820	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612
1091501005821	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
1091501005822	FOG: CBS domain [General function prediction only]; Region: COG0517
1091501005823	peptide chain release factor 1; Provisional; Region: PRK04011
1091501005824	SHS2 domain protein implicated in nucleic acid metabolism [General function prediction    only]; Region: COG1371
1091501005825	Uncharacterized protein family UPF0027; Region: UPF0027; cl17455
1091501005826	Uncharacterized conserved protein [Function unknown]; Region: RtcB; COG1690
1091501005827	Domain of unknown function (DUF1876); Region: DUF1876; pfam08962
1091501005828	PE family; Region: PE; pfam00934
1091501005829	Chloramphenicol (Cm) phosphotransferase (CPT). Cm-inactivating enzyme; modifies the primary (C-3) hydroxyl of the antibiotic. Related structurally to shikimate kinase II; Region: CPT; cl17391
1091501005830	P-loop motif; other site
1091501005831	ATP binding site [chemical binding]; other site
1091501005832	Chloramphenicol (Cm) binding site [chemical binding]; other site
1091501005833	catalytic residue [active]
1091501005834	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1091501005835	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
1091501005836	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
1091501005837	anti sigma factor interaction site; other site
1091501005838	regulatory phosphorylation site [posttranslational modification]; other site
1091501005839	hypothetical protein; Provisional; Region: PRK02237
1091501005840	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1091501005841	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1091501005842	putative DNA binding site [nucleotide binding]; other site
1091501005843	putative Zn2+ binding site [ion binding]; other site
1091501005844	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254
1091501005845	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1091501005846	putative metal binding site [ion binding]; other site
1091501005847	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1091501005848	dimerization interface [polypeptide binding]; other site
1091501005849	putative DNA binding site [nucleotide binding]; other site
1091501005850	putative Zn2+ binding site [ion binding]; other site
1091501005851	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
1091501005852	arsenical-resistance protein; Region: acr3; TIGR00832
1091501005853	Low molecular weight phosphatase family; Region: LMWPc; cd00115
1091501005854	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
1091501005855	active site
1091501005856	Protein of unknown function (DUF3018); Region: DUF3018; pfam11455
1091501005857	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
1091501005858	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495
1091501005859	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1091501005860	Transposase; Region: HTH_Tnp_1; cl17663
1091501005861	putative transposase OrfB; Reviewed; Region: PHA02517
1091501005862	HTH-like domain; Region: HTH_21; pfam13276
1091501005863	Integrase core domain; Region: rve; pfam00665
1091501005864	Integrase core domain; Region: rve_3; pfam13683
1091501005865	potential frameshift: common BLAST hit: gi|253798268|ref|YP_003031269.1| phiRv2 phage protein
1091501005866	Phage head maturation protease [General function prediction only]; Region: COG3740
1091501005867	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1091501005868	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1091501005869	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1091501005870	MULE transposase domain; Region: MULE; pfam10551
1091501005871	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
1091501005872	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1091501005873	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1091501005874	Coenzyme A binding pocket [chemical binding]; other site
1091501005875	AFG1-like ATPase; Region: AFG1_ATPase; pfam03969
1091501005876	hypothetical protein; Provisional; Region: PRK14059
1091501005877	Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985
1091501005878	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1091501005879	TAP-like protein; Region: Abhydrolase_4; pfam08386
1091501005880	potential frameshift: common BLAST hit: gi|340627674|ref|YP_004746126.1| putative integral membrane protein
1091501005881	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229
1091501005882	SelR domain; Region: SelR; pfam01641
1091501005883	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1091501005884	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1091501005885	S-adenosylmethionine binding site [chemical binding]; other site
1091501005886	Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253
1091501005887	protoporphyrinogen oxidase; Reviewed; Region: PRK11883
1091501005888	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1091501005889	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
1091501005890	substrate binding site [chemical binding]; other site
1091501005891	active site
1091501005892	potential frameshift: common BLAST hit: gi|340627680|ref|YP_004746132.1| putative enoyl-CoA hydratase ECHA15
1091501005893	Protein of unknown function (DUF3000); Region: DUF3000; pfam11452
1091501005894	Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154
1091501005895	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
1091501005896	TPP-binding site; other site
1091501005897	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1091501005898	PYR/PP interface [polypeptide binding]; other site
1091501005899	dimer interface [polypeptide binding]; other site
1091501005900	TPP binding site [chemical binding]; other site
1091501005901	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1091501005902	FOG: CBS domain [General function prediction only]; Region: COG0517
1091501005903	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
1091501005904	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
1091501005905	Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116
1091501005906	transmembrane helices; other site
1091501005907	potential frameshift: common BLAST hit: gi|340627686|ref|YP_004746138.1| putative arsenic-transport integral membrane protein ARSB1
1091501005908	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1091501005909	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1091501005910	Walker A/P-loop; other site
1091501005911	ATP binding site [chemical binding]; other site
1091501005912	Q-loop/lid; other site
1091501005913	ABC transporter signature motif; other site
1091501005914	Walker B; other site
1091501005915	D-loop; other site
1091501005916	H-loop/switch region; other site
1091501005917	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
1091501005918	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
1091501005919	TrkA-N domain; Region: TrkA_N; pfam02254
1091501005920	TrkA-C domain; Region: TrkA_C; pfam02080
1091501005921	Protein of unknown function (DUF3159); Region: DUF3159; pfam11361
1091501005922	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
1091501005923	generic binding surface II; other site
1091501005924	ssDNA binding site; other site
1091501005925	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
1091501005926	trimer interface [polypeptide binding]; other site
1091501005927	active site
1091501005928	Protein of unknown function (DUF3093); Region: DUF3093; pfam11292
1091501005929	Domain of unknown function (DUF4193); Region: DUF4193; pfam13834
1091501005930	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
1091501005931	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1091501005932	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
1091501005933	active site
1091501005934	dimerization interface [polypeptide binding]; other site
1091501005935	potential frameshift: common BLAST hit: gi|148662543|ref|YP_001284066.1| polyphosphate glucokinase
1091501005936	RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921
1091501005937	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1091501005938	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1091501005939	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1091501005940	DNA binding residues [nucleotide binding]
1091501005941	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154
1091501005942	homotrimer interaction site [polypeptide binding]; other site
1091501005943	putative active site [active]
1091501005944	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3502
1091501005945	Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295
1091501005946	Protein of unknown function (DUF3039); Region: DUF3039; pfam11238
1091501005947	Protein of unknown function (DUF3099); Region: DUF3099; pfam11298
1091501005948	RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921
1091501005949	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
1091501005950	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1091501005951	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1091501005952	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1091501005953	DNA binding residues [nucleotide binding]
1091501005954	Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
1091501005955	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
1091501005956	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
1091501005957	This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899
1091501005958	Domain of unknown function (DUF4192); Region: DUF4192; pfam13830
1091501005959	potential frameshift: common BLAST hit: gi|340627714|ref|YP_004746166.1| putative soluble pyridine nucleotide transhydrogenase STHA
1091501005960	PAC2 family; Region: PAC2; pfam09754
1091501005961	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1091501005962	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
1091501005963	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
1091501005964	nitrobindin heme-binding domain; Region: nitrobindin; cd07828
1091501005965	heme-binding site [chemical binding]; other site
1091501005966	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107
1091501005967	LexA repressor; Validated; Region: PRK00215
1091501005968	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
1091501005969	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
1091501005970	Catalytic site [active]
1091501005971	Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479
1091501005972	LGFP repeat; Region: LGFP; pfam08310
1091501005973	LGFP repeat; Region: LGFP; pfam08310
1091501005974	LGFP repeat; Region: LGFP; pfam08310
1091501005975	LGFP repeat; Region: LGFP; pfam08310
1091501005976	LGFP repeat; Region: LGFP; pfam08310
1091501005977	potential frameshift: common BLAST hit: gi|340627724|ref|YP_004746176.1| putative integral membrane protein
1091501005978	potential frameshift: common BLAST hit: gi|15842262|ref|NP_337299.1| acyl-CoA dehydrogenase
1091501005979	GTPases [General function prediction only]; Region: HflX; COG2262
1091501005980	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
1091501005981	HflX GTPase family; Region: HflX; cd01878
1091501005982	G1 box; other site
1091501005983	GTP/Mg2+ binding site [chemical binding]; other site
1091501005984	Switch I region; other site
1091501005985	G2 box; other site
1091501005986	G3 box; other site
1091501005987	Switch II region; other site
1091501005988	G4 box; other site
1091501005989	G5 box; other site
1091501005990	diaminopimelate epimerase; Region: DapF; TIGR00652
1091501005991	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
1091501005992	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
1091501005993	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
1091501005994	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
1091501005995	Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599
1091501005996	active site
1091501005997	metal binding site [ion binding]; metal-binding site
1091501005998	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
1091501005999	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
1091501006000	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
1091501006001	potential frameshift: common BLAST hit: gi|224991100|ref|YP_002645789.1| (dimethylallyl)adenosine tRNA methylthiotransferase
1091501006002	Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384
1091501006003	RecX family; Region: RecX; cl00936
1091501006004	DNA recombination protein RecA; Reviewed; Region: recA; PRK09519
1091501006005	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
1091501006006	hexamer interface [polypeptide binding]; other site
1091501006007	Walker A motif; other site
1091501006008	ATP binding site [chemical binding]; other site
1091501006009	Walker B motif; other site
1091501006010	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
1091501006011	protein-splicing catalytic site; other site
1091501006012	thioester formation/cholesterol transfer; other site
1091501006013	Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305
1091501006014	recA bacterial DNA recombination protein; Region: RecA; cl17211
1091501006015	FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575
1091501006016	Protein of unknown function (DUF3046); Region: DUF3046; pfam11248
1091501006017	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
1091501006018	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1091501006019	Limonene-1,2-epoxide hydrolase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LimA; COG4308
1091501006020	PE family; Region: PE; pfam00934
1091501006021	Protein of unknown function (DUF3046); Region: DUF3046; pfam11248
1091501006022	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
1091501006023	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
1091501006024	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1091501006025	non-specific DNA binding site [nucleotide binding]; other site
1091501006026	salt bridge; other site
1091501006027	sequence-specific DNA binding site [nucleotide binding]; other site
1091501006028	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
1091501006029	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1091501006030	Coenzyme A binding pocket [chemical binding]; other site
1091501006031	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
1091501006032	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1091501006033	This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843
1091501006034	Uncharacterized conserved protein [Function unknown]; Region: COG1359
1091501006035	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
1091501006036	classical (c) SDRs; Region: SDR_c; cd05233
1091501006037	NAD(P) binding site [chemical binding]; other site
1091501006038	active site
1091501006039	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
1091501006040	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
1091501006041	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
1091501006042	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1091501006043	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
1091501006044	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
1091501006045	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
1091501006046	dimer interface [polypeptide binding]; other site
1091501006047	active site
1091501006048	catalytic residue [active]
1091501006049	FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847
1091501006050	HsdM N-terminal domain; Region: HsdM_N; pfam12161
1091501006051	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
1091501006052	Methyltransferase domain; Region: Methyltransf_26; pfam13659
1091501006053	PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882
1091501006054	putative active site [active]
1091501006055	Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450
1091501006056	PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871
1091501006057	putative active site [active]
1091501006058	Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704
1091501006059	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
1091501006060	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
1091501006061	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214
1091501006062	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
1091501006063	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
1091501006064	folate binding site [chemical binding]; other site
1091501006065	NADP+ binding site [chemical binding]; other site
1091501006066	thymidylate synthase; Reviewed; Region: thyA; PRK01827
1091501006067	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
1091501006068	dimerization interface [polypeptide binding]; other site
1091501006069	active site
1091501006070	Dienelactone hydrolase family; Region: DLH; pfam01738
1091501006071	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
1091501006072	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
1091501006073	classical (c) SDRs; Region: SDR_c; cd05233
1091501006074	NAD(P) binding site [chemical binding]; other site
1091501006075	active site
1091501006076	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1091501006077	PPE family; Region: PPE; pfam00823
1091501006078	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
1091501006079	PE family; Region: PE; pfam00934
1091501006080	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
1091501006081	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1091501006082	PPE family; Region: PPE; pfam00823
1091501006083	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
1091501006084	dihydrodipicolinate reductase; Provisional; Region: PRK00048
1091501006085	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
1091501006086	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
1091501006087	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1091501006088	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1091501006089	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1091501006090	Coenzyme A binding pocket [chemical binding]; other site
1091501006091	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
1091501006092	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
1091501006093	FMN-binding pocket [chemical binding]; other site
1091501006094	flavin binding motif; other site
1091501006095	phosphate binding motif [ion binding]; other site
1091501006096	beta-alpha-beta structure motif; other site
1091501006097	NAD binding pocket [chemical binding]; other site
1091501006098	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
1091501006099	hydrophobic ligand binding site; other site
1091501006100	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
1091501006101	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1091501006102	putative DNA binding site [nucleotide binding]; other site
1091501006103	putative Zn2+ binding site [ion binding]; other site
1091501006104	AsnC family; Region: AsnC_trans_reg; pfam01037
1091501006105	alanine dehydrogenase; Region: alaDH; TIGR00518
1091501006106	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
1091501006107	hexamer interface [polypeptide binding]; other site
1091501006108	ligand binding site [chemical binding]; other site
1091501006109	putative active site [active]
1091501006110	NAD(P) binding site [chemical binding]; other site
1091501006111	Nitronate monooxygenase; Region: NMO; pfam03060
1091501006112	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
1091501006113	FMN binding site [chemical binding]; other site
1091501006114	substrate binding site [chemical binding]; other site
1091501006115	putative catalytic residue [active]
1091501006116	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1091501006117	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
1091501006118	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1091501006119	potential frameshift: common BLAST hit: gi|339632794|ref|YP_004724436.1| polyribonucleotide nucleotidyltransferase
1091501006120	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
1091501006121	16S/18S rRNA binding site [nucleotide binding]; other site
1091501006122	S13e-L30e interaction site [polypeptide binding]; other site
1091501006123	25S rRNA binding site [nucleotide binding]; other site
1091501006124	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
1091501006125	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
1091501006126	active site
1091501006127	Riboflavin kinase; Region: Flavokinase; pfam01687
1091501006128	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
1091501006129	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
1091501006130	potential frameshift: common BLAST hit: gi|224991160|ref|YP_002645849.1| transcriptional repressor
1091501006131	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1091501006132	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1091501006133	active site
1091501006134	lipid-transfer protein; Provisional; Region: PRK08256
1091501006135	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
1091501006136	active site
1091501006137	potential frameshift: common BLAST hit: gi|339632802|ref|YP_004724444.1| transposase
1091501006138	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
1091501006139	Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769
1091501006140	catalytic residues [active]
1091501006141	catalytic nucleophile [active]
1091501006142	potential frameshift: common BLAST hit: gi|339632804|ref|YP_004724446.1| tRNA pseudouridine synthase B TRUB
1091501006143	Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977
1091501006144	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
1091501006145	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
1091501006146	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1091501006147	active site
1091501006148	metal binding site [ion binding]; metal-binding site
1091501006149	Uncharacterized conserved protein [Function unknown]; Region: COG4717
1091501006150	Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259
1091501006151	Protein of unknown function (DUF3558); Region: DUF3558; pfam12079
1091501006152	Predicted acyl esterases [General function prediction only]; Region: COG2936
1091501006153	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939
1091501006154	Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337
1091501006155	Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864
1091501006156	Uncharacterized conserved protein [Function unknown]; Region: COG5586
1091501006157	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453
1091501006158	Integrase core domain; Region: rve; pfam00665
1091501006159	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
1091501006160	Transposase; Region: DDE_Tnp_ISL3; pfam01610
1091501006161	Helix-turn-helix domain; Region: HTH_28; pfam13518
1091501006162	Winged helix-turn helix; Region: HTH_29; pfam13551
1091501006163	Integrase core domain; Region: rve; pfam00665
1091501006164	Integrase core domain; Region: rve_3; pfam13683
1091501006165	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
1091501006166	Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267
1091501006167	putative transposase OrfB; Reviewed; Region: PHA02517
1091501006168	HTH-like domain; Region: HTH_21; pfam13276
1091501006169	Integrase core domain; Region: rve; pfam00665
1091501006170	Integrase core domain; Region: rve_3; pfam13683
1091501006171	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1091501006172	Transposase; Region: HTH_Tnp_1; cl17663
1091501006173	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638
1091501006174	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09636
1091501006175	CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cd09699
1091501006176	CRISPR/Cas system-associated RAMP superfamily protein Csm5; Region: Csm5_III-A; cd09662
1091501006177	potential frameshift: common BLAST hit: gi|253798095|ref|YP_003031096.1| csm4 family CRISPR-associated ramp protein
1091501006178	CRISPR/Cas system-associated RAMP superfamily protein Csm3; Region: Csm3_III-A; cd09684
1091501006179	CRISPR/Cas system-associated protein Csm2; Region: Csm2_III-A; cd09647
1091501006180	Predicted CRISPR-associated polymerase [Defense mechanisms]; Region: COG1353
1091501006181	CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680
1091501006182	CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652
1091501006183	Domain of unknown function (DUF1802); Region: DUF1802; cl01755
1091501006184	Uncharacterized conserved protein [Function unknown]; Region: COG2253
1091501006185	Domain of unknown function (DUF1802); Region: DUF1802; cl01755
1091501006186	Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041
1091501006187	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
1091501006188	putative active site [active]
1091501006189	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
1091501006190	potential frameshift: common BLAST hit: gi|339632840|ref|YP_004724482.1| enoyl-CoA hydratase
1091501006191	potential frameshift: common BLAST hit: gi|339632841|ref|YP_004724483.1| Sn-glycerol-3-phosphate transport ATP-binding protein ABC
1091501006192	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1091501006193	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1091501006194	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1091501006195	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1091501006196	dimer interface [polypeptide binding]; other site
1091501006197	conserved gate region; other site
1091501006198	putative PBP binding loops; other site
1091501006199	ABC-ATPase subunit interface; other site
1091501006200	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1091501006201	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1091501006202	dimer interface [polypeptide binding]; other site
1091501006203	conserved gate region; other site
1091501006204	putative PBP binding loops; other site
1091501006205	ABC-ATPase subunit interface; other site
1091501006206	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
1091501006207	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
1091501006208	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
1091501006209	DHH family; Region: DHH; pfam01368
1091501006210	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
1091501006211	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
1091501006212	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
1091501006213	Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532
1091501006214	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
1091501006215	G1 box; other site
1091501006216	putative GEF interaction site [polypeptide binding]; other site
1091501006217	GTP/Mg2+ binding site [chemical binding]; other site
1091501006218	Switch I region; other site
1091501006219	G2 box; other site
1091501006220	G3 box; other site
1091501006221	Switch II region; other site
1091501006222	G4 box; other site
1091501006223	G5 box; other site
1091501006224	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
1091501006225	Translation-initiation factor 2; Region: IF-2; pfam11987
1091501006226	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
1091501006227	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cl00189
1091501006228	putative RNA binding cleft [nucleotide binding]; other site
1091501006229	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
1091501006230	NusA N-terminal domain; Region: NusA_N; pfam08529
1091501006231	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
1091501006232	RNA binding site [nucleotide binding]; other site
1091501006233	homodimer interface [polypeptide binding]; other site
1091501006234	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
1091501006235	G-X-X-G motif; other site
1091501006236	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
1091501006237	G-X-X-G motif; other site
1091501006238	ribosome maturation protein RimP; Reviewed; Region: PRK00092
1091501006239	Sm and related proteins; Region: Sm_like; cl00259
1091501006240	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
1091501006241	putative oligomer interface [polypeptide binding]; other site
1091501006242	putative RNA binding site [nucleotide binding]; other site
1091501006243	Mitochondrial ATP synthase g subunit; Region: ATP-synt_G; pfam04718
1091501006244	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
1091501006245	dinuclear metal binding motif [ion binding]; other site
1091501006246	prolyl-tRNA synthetase; Provisional; Region: PRK09194
1091501006247	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
1091501006248	dimer interface [polypeptide binding]; other site
1091501006249	motif 1; other site
1091501006250	active site
1091501006251	motif 2; other site
1091501006252	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022
1091501006253	putative deacylase active site [active]
1091501006254	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1091501006255	active site
1091501006256	motif 3; other site
1091501006257	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
1091501006258	anticodon binding site; other site
1091501006259	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1091501006260	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1091501006261	putative substrate translocation pore; other site
1091501006262	Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648
1091501006263	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
1091501006264	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
1091501006265	homodimer interface [polypeptide binding]; other site
1091501006266	active site
1091501006267	SAM binding site [chemical binding]; other site
1091501006268	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
1091501006269	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1091501006270	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
1091501006271	catalytic triad [active]
1091501006272	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
1091501006273	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
1091501006274	homodimer interface [polypeptide binding]; other site
1091501006275	Walker A motif; other site
1091501006276	ATP binding site [chemical binding]; other site
1091501006277	hydroxycobalamin binding site [chemical binding]; other site
1091501006278	Walker B motif; other site
1091501006279	potential frameshift: common BLAST hit: gi|15842391|ref|NP_337428.1| magnesium chelatase
1091501006280	potential frameshift: common BLAST hit: gi|340627843|ref|YP_004746295.1| putative magnesium chelatase
1091501006281	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1091501006282	malate:quinone oxidoreductase; Validated; Region: PRK05257
1091501006283	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
1091501006284	PE family; Region: PE; pfam00934
1091501006285	potential frameshift: common BLAST hit: gi|339632864|ref|YP_004724506.1| NADPH-dependent mycothiol reductase MTR
1091501006286	potential frameshift: common BLAST hit: gi|339632865|ref|YP_004724507.1| nickel-transport integral membrane protein NICT
1091501006287	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1091501006288	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1091501006289	short chain dehydrogenase; Provisional; Region: PRK06057
1091501006290	classical (c) SDRs; Region: SDR_c; cd05233
1091501006291	NAD(P) binding site [chemical binding]; other site
1091501006292	active site
1091501006293	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1091501006294	NAD(P)+ dependent aldehyde dehydrogenase family; Region: ALDH; cd07078
1091501006295	NAD(P) binding site [chemical binding]; other site
1091501006296	catalytic residues [active]
1091501006297	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
1091501006298	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
1091501006299	catalytic triad [active]
1091501006300	potential frameshift: common BLAST hit: gi|340627853|ref|YP_004746305.1| putative glutamine synthetase
1091501006301	potential frameshift: common BLAST hit: gi|340627854|ref|YP_004746306.1| putative methionine aminopeptidase MAPB
1091501006302	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
1091501006303	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
1091501006304	putative active site [active]
1091501006305	NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223
1091501006306	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
1091501006307	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1091501006308	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161
1091501006309	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
1091501006310	Predicted acetyltransferase [General function prediction only]; Region: COG3393
1091501006311	Domain of unknown function (DUF4081); Region: DUF4081; pfam13312
1091501006312	potential frameshift: common BLAST hit: gi|339632877|ref|YP_004724519.1| GCPE protein
1091501006313	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
1091501006314	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
1091501006315	active site
1091501006316	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
1091501006317	protein binding site [polypeptide binding]; other site
1091501006318	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
1091501006319	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
1091501006320	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
1091501006321	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
1091501006322	Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028
1091501006323	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
1091501006324	Fasciclin domain; Region: Fasciclin; pfam02469
1091501006325	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
1091501006326	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
1091501006327	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
1091501006328	TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012
1091501006329	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1091501006330	catalytic residues [active]
1091501006331	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
1091501006332	Fasciclin domain; Region: Fasciclin; pfam02469
1091501006333	Protein of unknown function (DUF2631); Region: DUF2631; pfam10939
1091501006334	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
1091501006335	TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011
1091501006336	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1091501006337	catalytic residues [active]
1091501006338	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459
1091501006339	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1091501006340	FeS/SAM binding site; other site
1091501006341	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
1091501006342	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
1091501006343	ribosome recycling factor; Reviewed; Region: frr; PRK00083
1091501006344	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
1091501006345	hinge region; other site
1091501006346	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
1091501006347	putative nucleotide binding site [chemical binding]; other site
1091501006348	uridine monophosphate binding site [chemical binding]; other site
1091501006349	homohexameric interface [polypeptide binding]; other site
1091501006350	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1091501006351	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1091501006352	DNA binding site [nucleotide binding]
1091501006353	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
1091501006354	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
1091501006355	Probable transposase; Region: OrfB_IS605; pfam01385
1091501006356	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
1091501006357	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
1091501006358	catalytic residues [active]
1091501006359	catalytic nucleophile [active]
1091501006360	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1091501006361	MarR family; Region: MarR; pfam01047
1091501006362	amidase; Provisional; Region: PRK07869
1091501006363	Amidase; Region: Amidase; pfam01425
1091501006364	elongation factor Ts; Provisional; Region: tsf; PRK09377
1091501006365	UBA/TS-N domain; Region: UBA; pfam00627
1091501006366	Elongation factor TS; Region: EF_TS; pfam00889
1091501006367	Elongation factor TS; Region: EF_TS; pfam00889
1091501006368	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
1091501006369	rRNA interaction site [nucleotide binding]; other site
1091501006370	S8 interaction site; other site
1091501006371	putative laminin-1 binding site; other site
1091501006372	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1091501006373	Peptidase family M23; Region: Peptidase_M23; pfam01551
1091501006374	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1091501006375	PPE family; Region: PPE; pfam00823
1091501006376	probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621
1091501006377	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1091501006378	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
1091501006379	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1091501006380	active site
1091501006381	DNA binding site [nucleotide binding]
1091501006382	Int/Topo IB signature motif; other site
1091501006383	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
1091501006384	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
1091501006385	FAD binding pocket [chemical binding]; other site
1091501006386	FAD binding motif [chemical binding]; other site
1091501006387	phosphate binding motif [ion binding]; other site
1091501006388	NAD binding pocket [chemical binding]; other site
1091501006389	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
1091501006390	DNA protecting protein DprA; Region: dprA; TIGR00732
1091501006391	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
1091501006392	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
1091501006393	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1091501006394	Walker A motif; other site
1091501006395	ATP binding site [chemical binding]; other site
1091501006396	Walker B motif; other site
1091501006397	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
1091501006398	hypothetical protein; Reviewed; Region: PRK12497
1091501006399	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
1091501006400	potential frameshift: common BLAST hit: gi|339632906|ref|YP_004724548.1| formate dehydrogenase
1091501006401	Protein of unknown function (DUF2469); Region: DUF2469; pfam10611
1091501006402	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
1091501006403	RNA/DNA hybrid binding site [nucleotide binding]; other site
1091501006404	active site
1091501006405	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
1091501006406	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1091501006407	Catalytic site [active]
1091501006408	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1091501006409	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
1091501006410	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1091501006411	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
1091501006412	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
1091501006413	RimM N-terminal domain; Region: RimM; pfam01782
1091501006414	hypothetical protein; Provisional; Region: PRK02821
1091501006415	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
1091501006416	G-X-X-G motif; other site
1091501006417	30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520
1091501006418	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531
1091501006419	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
1091501006420	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1091501006421	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1091501006422	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1091501006423	potential frameshift: common BLAST hit: gi|339632919|ref|YP_004724561.1| D-amino acid aminohydrolase
1091501006424	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1091501006425	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1091501006426	active site
1091501006427	ATP binding site [chemical binding]; other site
1091501006428	substrate binding site [chemical binding]; other site
1091501006429	activation loop (A-loop); other site
1091501006430	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
1091501006431	Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299
1091501006432	active site
1091501006433	potential frameshift: common BLAST hit: gi|340627906|ref|YP_004746358.1| putative signal recognition particle protein FFH
1091501006434	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
1091501006435	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1091501006436	ATP binding site [chemical binding]; other site
1091501006437	putative Mg++ binding site [ion binding]; other site
1091501006438	potential frameshift: common BLAST hit: gi|339632924|ref|YP_004724566.1| PII uridylyltransferase
1091501006439	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
1091501006440	Nitrogen regulatory protein P-II; Region: P-II; smart00938
1091501006441	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
1091501006442	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
1091501006443	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
1091501006444	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1091501006445	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
1091501006446	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
1091501006447	Walker A/P-loop; other site
1091501006448	ATP binding site [chemical binding]; other site
1091501006449	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
1091501006450	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
1091501006451	ABC transporter signature motif; other site
1091501006452	Walker B; other site
1091501006453	D-loop; other site
1091501006454	H-loop/switch region; other site
1091501006455	acylphosphatase; Provisional; Region: PRK14422
1091501006456	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
1091501006457	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
1091501006458	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
1091501006459	DNA binding site [nucleotide binding]
1091501006460	catalytic residue [active]
1091501006461	H2TH interface [polypeptide binding]; other site
1091501006462	putative catalytic residues [active]
1091501006463	turnover-facilitating residue; other site
1091501006464	intercalation triad [nucleotide binding]; other site
1091501006465	8OG recognition residue [nucleotide binding]; other site
1091501006466	putative reading head residues; other site
1091501006467	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
1091501006468	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1091501006469	ribonuclease III; Reviewed; Region: rnc; PRK00102
1091501006470	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
1091501006471	dimerization interface [polypeptide binding]; other site
1091501006472	active site
1091501006473	metal binding site [ion binding]; metal-binding site
1091501006474	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
1091501006475	dsRNA binding site [nucleotide binding]; other site
1091501006476	Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399
1091501006477	Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599
1091501006478	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
1091501006479	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
1091501006480	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
1091501006481	active site
1091501006482	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1091501006483	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1091501006484	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
1091501006485	active site
1091501006486	Acyl transferase domain; Region: Acyl_transf_1; pfam00698
1091501006487	ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274
1091501006488	NADP binding site [chemical binding]; other site
1091501006489	KR domain; Region: KR; pfam08659
1091501006490	active site
1091501006491	potential frameshift: common BLAST hit: gi|224991306|ref|YP_002645995.1| phenolpthiocerol synthesis type-I polyketide synthase
1091501006492	potential frameshift: common BLAST hit: gi|339632940|ref|YP_004724582.1| phenolpthiocerol synthesis type-I polyketide synthase PPSC
1091501006493	potential frameshift: common BLAST hit: gi|339632940|ref|YP_004724582.1| phenolpthiocerol synthesis type-I polyketide synthase PPSC
1091501006494	potential frameshift: common BLAST hit: gi|339632940|ref|YP_004724582.1| phenolpthiocerol synthesis type-I polyketide synthase PPSC
1091501006495	potential frameshift: common BLAST hit: gi|339632941|ref|YP_004724583.1| phenolpthiocerol synthesis type-I polyketide synthase PPSD
1091501006496	potential frameshift: common BLAST hit: gi|339632941|ref|YP_004724583.1| phenolpthiocerol synthesis type-I polyketide synthase PPSD
1091501006497	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
1091501006498	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1091501006499	active site
1091501006500	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
1091501006501	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1091501006502	Condensation domain; Region: Condensation; pfam00668
1091501006503	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
1091501006504	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1091501006505	daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
1091501006506	Walker A/P-loop; other site
1091501006507	ATP binding site [chemical binding]; other site
1091501006508	Q-loop/lid; other site
1091501006509	ABC transporter signature motif; other site
1091501006510	Walker B; other site
1091501006511	D-loop; other site
1091501006512	H-loop/switch region; other site
1091501006513	ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025
1091501006514	ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025
1091501006515	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1091501006516	potential frameshift: common BLAST hit: gi|340627930|ref|YP_004746382.1| putative polyketide synthase associated protein PAPA5
1091501006517	potential frameshift: common BLAST hit: gi|253797972|ref|YP_003030973.1| multifunctional mycocerosic acid synthase membrane-associated mas
1091501006518	potential frameshift: common BLAST hit: gi|253797972|ref|YP_003030973.1| multifunctional mycocerosic acid synthase membrane-associated mas
1091501006519	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1091501006520	acyl-activating enzyme (AAE) consensus motif; other site
1091501006521	potential frameshift: common BLAST hit: gi|340627932|ref|YP_004746384.1| fatty-acid-CoA ligase FADD28
1091501006522	potential frameshift: common BLAST hit: gi|253797970|ref|YP_003030971.1| transmembrane transporter mmpL7
1091501006523	potential frameshift: common BLAST hit: gi|339632950|ref|YP_004724592.1| transposase for insertion sequence element IS1533
1091501006524	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
1091501006525	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
1091501006526	Protein of unknown function (DUF1396); Region: DUF1396; pfam07161
1091501006527	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
1091501006528	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
1091501006529	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
1091501006530	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1091501006531	Enoylreductase; Region: PKS_ER; smart00829
1091501006532	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
1091501006533	NAD(P) binding site [chemical binding]; other site
1091501006534	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956
1091501006535	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
1091501006536	putative NADP binding site [chemical binding]; other site
1091501006537	active site
1091501006538	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
1091501006539	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1091501006540	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
1091501006541	active site
1091501006542	Erythronolide synthase docking; Region: Docking; pfam08990
1091501006543	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
1091501006544	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1091501006545	acyl-CoA synthetase; Validated; Region: PRK06060
1091501006546	Benzoate CoA ligase (BCL) and similar adenylate forming enzymes; Region: BCL_like; cd05919
1091501006547	dimer interface [polypeptide binding]; other site
1091501006548	acyl-activating enzyme (AAE) consensus motif; other site
1091501006549	putative active site [active]
1091501006550	putative AMP binding site [chemical binding]; other site
1091501006551	putative CoA binding site [chemical binding]; other site
1091501006552	chemical substrate binding site [chemical binding]; other site
1091501006553	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
1091501006554	4-hydroxybenzoate synthetase (chorismate lyase) [Coenzyme metabolism]; Region: UbiC; COG3161
1091501006555	potential frameshift: common BLAST hit: gi|339632957|ref|YP_004724599.1| fatty-acid-CoA ligase
1091501006556	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
1091501006557	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
1091501006558	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1091501006559	S-adenosylmethionine binding site [chemical binding]; other site
1091501006560	Uncharacterized conserved protein [Function unknown]; Region: COG3268
1091501006561	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1091501006562	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1091501006563	S-adenosylmethionine binding site [chemical binding]; other site
1091501006564	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
1091501006565	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
1091501006566	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
1091501006567	metal-binding site
1091501006568	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1091501006569	potential frameshift: common BLAST hit: gi|340627949|ref|YP_004746401.1| putative glycosyl transferase
1091501006570	Cephalosporin hydroxylase [Defense mechanisms]; Region: CmcI; COG3510
1091501006571	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
1091501006572	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
1091501006573	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
1091501006574	active site
1091501006575	TDP-binding site; other site
1091501006576	Predicted permease; Region: DUF318; pfam03773
1091501006577	formyltetrahydrofolate deformylase; Region: PurU; TIGR00655
1091501006578	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
1091501006579	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
1091501006580	putative active site [active]
1091501006581	putative substrate binding site [chemical binding]; other site
1091501006582	putative cosubstrate binding site; other site
1091501006583	catalytic site [active]
1091501006584	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
1091501006585	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
1091501006586	active site
1091501006587	(T/H)XGH motif; other site
1091501006588	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
1091501006589	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1091501006590	S-adenosylmethionine binding site [chemical binding]; other site
1091501006591	pyruvate carboxylase; Reviewed; Region: PRK12999
1091501006592	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1091501006593	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1091501006594	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1091501006595	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
1091501006596	active site
1091501006597	catalytic residues [active]
1091501006598	metal binding site [ion binding]; metal-binding site
1091501006599	homodimer binding site [polypeptide binding]; other site
1091501006600	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
1091501006601	lipoyl-biotinyl attachment site [posttranslational modification]; other site
1091501006602	Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922
1091501006603	putative active site [active]
1091501006604	redox center [active]
1091501006605	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
1091501006606	DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972
1091501006607	catalytic residues [active]
1091501006608	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1091501006609	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1091501006610	substrate binding pocket [chemical binding]; other site
1091501006611	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470
1091501006612	potential frameshift: common BLAST hit: gi|340627961|ref|YP_004746413.1| putative oxidoreductase
1091501006613	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
1091501006614	RecG-like helicase [DNA replication, recombination, and repair / Transcription]; Region: RecG; COG1200
1091501006615	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
1091501006616	generic binding surface II; other site
1091501006617	ssDNA binding site; other site
1091501006618	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1091501006619	ATP binding site [chemical binding]; other site
1091501006620	putative Mg++ binding site [ion binding]; other site
1091501006621	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1091501006622	nucleotide binding region [chemical binding]; other site
1091501006623	ATP-binding site [chemical binding]; other site
1091501006624	potential frameshift: common BLAST hit: gi|340627964|ref|YP_004746416.1| dak2 domain-containing protein
1091501006625	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
1091501006626	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
1091501006627	ligand binding site [chemical binding]; other site
1091501006628	active site
1091501006629	UGI interface [polypeptide binding]; other site
1091501006630	catalytic site [active]
1091501006631	thiamine monophosphate kinase; Provisional; Region: PRK05731
1091501006632	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
1091501006633	ATP binding site [chemical binding]; other site
1091501006634	dimerization interface [polypeptide binding]; other site
1091501006635	potential frameshift: common BLAST hit: gi|253797929|ref|YP_003030930.1| transposase
1091501006636	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
1091501006637	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
1091501006638	catalytic residues [active]
1091501006639	catalytic nucleophile [active]
1091501006640	Protein of unknown function (DUF3515); Region: DUF3515; pfam12028
1091501006641	potential frameshift: common BLAST hit: gi|339632987|ref|YP_004724629.1| D-alanine--D-alanine ligase
1091501006642	potential frameshift: common BLAST hit: gi|340627971|ref|YP_004746423.1| putative glycerol-3-phosphate dehydrogenase
1091501006643	Predicted nucleotidyltransferase, CobY/MobA/RfbA family [General function prediction only]; Region: COG1920
1091501006644	polyphosphate kinase; Provisional; Region: PRK05443
1091501006645	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
1091501006646	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
1091501006647	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
1091501006648	putative domain interface [polypeptide binding]; other site
1091501006649	putative active site [active]
1091501006650	catalytic site [active]
1091501006651	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
1091501006652	putative domain interface [polypeptide binding]; other site
1091501006653	putative active site [active]
1091501006654	catalytic site [active]
1091501006655	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
1091501006656	active site
1091501006657	Ap6A binding site [chemical binding]; other site
1091501006658	nudix motif; other site
1091501006659	metal binding site [ion binding]; metal-binding site
1091501006660	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1091501006661	catalytic core [active]
1091501006662	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1091501006663	IHF - DNA interface [nucleotide binding]; other site
1091501006664	IHF dimer interface [polypeptide binding]; other site
1091501006665	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
1091501006666	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
1091501006667	substrate binding site [chemical binding]; other site
1091501006668	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
1091501006669	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
1091501006670	substrate binding site [chemical binding]; other site
1091501006671	ligand binding site [chemical binding]; other site
1091501006672	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
1091501006673	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1091501006674	Bacterial transcriptional regulator; Region: IclR; pfam01614
1091501006675	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1091501006676	S-adenosylmethionine binding site [chemical binding]; other site
1091501006677	Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871
1091501006678	PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618
1091501006679	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
1091501006680	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1091501006681	active site
1091501006682	HIGH motif; other site
1091501006683	nucleotide binding site [chemical binding]; other site
1091501006684	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1091501006685	active site
1091501006686	KMSKS motif; other site
1091501006687	Domain of unknown function (DUF2437); Region: DUF2437; pfam10370
1091501006688	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
1091501006689	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1091501006690	potential frameshift: common BLAST hit: gi|340627983|ref|YP_004746435.1| putative integral membrane protein
1091501006691	3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437
1091501006692	potential frameshift: common BLAST hit: gi|340627985|ref|YP_004746437.1| putative D-3-phosphoglycerate dehydrogenase SERA1
1091501006693	potential frameshift: common BLAST hit: gi|340627985|ref|YP_004746437.1| putative D-3-phosphoglycerate dehydrogenase SERA1
1091501006694	potential frameshift: common BLAST hit: gi|340627985|ref|YP_004746437.1| putative D-3-phosphoglycerate dehydrogenase SERA1
1091501006695	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
1091501006696	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1091501006697	Protein of unknown function (DUF433); Region: DUF433; pfam04255
1091501006698	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
1091501006699	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
1091501006700	phosphorylation site [posttranslational modification]
1091501006701	Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485
1091501006702	Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485
1091501006703	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390
1091501006704	ketol-acid reductoisomerase; Provisional; Region: PRK05479
1091501006705	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
1091501006706	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
1091501006707	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
1091501006708	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
1091501006709	putative valine binding site [chemical binding]; other site
1091501006710	dimer interface [polypeptide binding]; other site
1091501006711	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
1091501006712	potential frameshift: common BLAST hit: gi|339633010|ref|YP_004724652.1| acetolactate synthase large subunit
1091501006713	Protein of unknown function (DUF2581); Region: DUF2581; pfam10756
1091501006714	Predicted membrane protein [Function unknown]; Region: COG2259
1091501006715	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
1091501006716	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
1091501006717	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
1091501006718	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
1091501006719	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
1091501006720	GatB domain; Region: GatB_Yqey; smart00845
1091501006721	potential frameshift: common BLAST hit: gi|339633017|ref|YP_004724659.1| 6-phosphofructokinase
1091501006722	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
1091501006723	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
1091501006724	aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, C subunit; Region: gatC; TIGR00135
1091501006725	ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887
1091501006726	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
1091501006727	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
1091501006728	nucleotide binding pocket [chemical binding]; other site
1091501006729	K-X-D-G motif; other site
1091501006730	catalytic site [active]
1091501006731	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
1091501006732	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
1091501006733	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
1091501006734	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
1091501006735	Dimer interface [polypeptide binding]; other site
1091501006736	CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310
1091501006737	potential frameshift: common BLAST hit: gi|340628006|ref|YP_004746458.1| putative lipoprotein LPQA
1091501006738	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842
1091501006739	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1091501006740	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1091501006741	PPE family; Region: PPE; pfam00823
1091501006742	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842
1091501006743	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1091501006744	PPE family; Region: PPE; pfam00823
1091501006745	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1091501006746	MULE transposase domain; Region: MULE; pfam10551
1091501006747	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
1091501006748	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
1091501006749	Ligand Binding Site [chemical binding]; other site
1091501006750	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
1091501006751	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
1091501006752	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1091501006753	catalytic residue [active]
1091501006754	Putative hemolysin [General function prediction only]; Region: COG3176
1091501006755	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
1091501006756	Electron transfer flavoprotein domain; Region: ETF; pfam01012
1091501006757	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
1091501006758	Ligand binding site [chemical binding]; other site
1091501006759	Electron transfer flavoprotein domain; Region: ETF; pfam01012
1091501006760	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1091501006761	S-adenosylmethionine binding site [chemical binding]; other site
1091501006762	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1091501006763	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1091501006764	Domain of unknown function (DUF4333); Region: DUF4333; pfam14230
1091501006765	Domain of unknown function (DUF4333); Region: DUF4333; pfam14230
1091501006766	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
1091501006767	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
1091501006768	trimer interface [polypeptide binding]; other site
1091501006769	active site
1091501006770	substrate binding site [chemical binding]; other site
1091501006771	CoA binding site [chemical binding]; other site
1091501006772	FOG: WD40-like repeat [Function unknown]; Region: COG1520
1091501006773	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
1091501006774	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1091501006775	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1091501006776	S-adenosylmethionine binding site [chemical binding]; other site
1091501006777	potential frameshift: common BLAST hit: gi|253797863|ref|YP_003030864.1| enoyl-CoA hydratase
1091501006778	potential frameshift: common BLAST hit: gi|253797861|ref|YP_003030862.1| ABC transporter ATP-binding protein
1091501006779	CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870
1091501006780	ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871
1091501006781	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
1091501006782	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1091501006783	motif II; other site
1091501006784	potential frameshift: common BLAST hit: gi|340628035|ref|YP_004746487.1| putative cytochrome C oxidase polypeptide I CTAD (cytochrome AA3
1091501006785	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
1091501006786	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
1091501006787	siderophore binding site; other site
1091501006788	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
1091501006789	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1091501006790	Protein of unknown function (DUF3349); Region: DUF3349; pfam11829
1091501006791	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
1091501006792	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
1091501006793	dimer interface [polypeptide binding]; other site
1091501006794	putative radical transfer pathway; other site
1091501006795	diiron center [ion binding]; other site
1091501006796	tyrosyl radical; other site
1091501006797	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
1091501006798	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
1091501006799	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1091501006800	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1091501006801	potential frameshift: common BLAST hit: gi|339633059|ref|YP_004724701.1| ribonucleoside-diphosphate reductase subunit alpha
1091501006802	potential frameshift: common BLAST hit: gi|339633059|ref|YP_004724701.1| ribonucleoside-diphosphate reductase subunit alpha
1091501006803	ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600
1091501006804	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
1091501006805	catalytic residues [active]
1091501006806	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1091501006807	Predicted flavoprotein [General function prediction only]; Region: COG0431
1091501006808	potential frameshift: common BLAST hit: gi|339633064|ref|YP_004724706.1| DNA polymerase V
1091501006809	potential frameshift: common BLAST hit: gi|339633064|ref|YP_004724706.1| DNA polymerase V
1091501006810	short chain dehydrogenase; Provisional; Region: PRK07832
1091501006811	classical (c) SDRs; Region: SDR_c; cd05233
1091501006812	NAD(P) binding site [chemical binding]; other site
1091501006813	active site
1091501006814	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1091501006815	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1091501006816	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1091501006817	Cytochrome P450; Region: p450; cl12078
1091501006818	potential frameshift: common BLAST hit: gi|339633068|ref|YP_004724710.1| GntR family transcriptional regulator
1091501006819	potential frameshift: common BLAST hit: gi|339633069|ref|YP_004724711.1| acyl-CoA dehydrogenase
1091501006820	potential frameshift: common BLAST hit: gi|339633069|ref|YP_004724711.1| acyl-CoA dehydrogenase
1091501006821	ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180
1091501006822	Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901
1091501006823	active site
1091501006824	DNA binding site [nucleotide binding]
1091501006825	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972
1091501006826	DNA binding site [nucleotide binding]
1091501006827	potential frameshift: common BLAST hit: gi|339633071|ref|YP_004724713.1| carbon starvation protein A homolog CSTA
1091501006828	DoxX; Region: DoxX; pfam07681
1091501006829	Small Multidrug Resistance protein; Region: Multi_Drug_Res; pfam00893
1091501006830	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226
1091501006831	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1091501006832	Protein of unknown function (DUF732); Region: DUF732; pfam05305
1091501006833	phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132
1091501006834	This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801
1091501006835	active site
1091501006836	substrate binding site [chemical binding]; other site
1091501006837	metal binding site [ion binding]; metal-binding site
1091501006838	camphor resistance protein CrcB; Provisional; Region: PRK14216
1091501006839	camphor resistance protein CrcB; Provisional; Region: PRK14228
1091501006840	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1091501006841	Uncharacterized conserved protein [Function unknown]; Region: COG3189
1091501006842	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
1091501006843	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
1091501006844	putative hydrophobic ligand binding site [chemical binding]; other site
1091501006845	protein interface [polypeptide binding]; other site
1091501006846	gate; other site
1091501006847	potential frameshift: common BLAST hit: gi|340628068|ref|YP_004746520.1| putative hydrolase
1091501006848	potential frameshift: common BLAST hit: gi|339633088|ref|YP_004724730.1| Ser/Thr protein kinase
1091501006849	Nucleotidyl transferase of unknown function (DUF2204); Region: DUF2204; pfam09970
1091501006850	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
1091501006851	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1091501006852	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1091501006853	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
1091501006854	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
1091501006855	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
1091501006856	short chain dehydrogenase; Provisional; Region: PRK07832
1091501006857	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1091501006858	NAD(P) binding site [chemical binding]; other site
1091501006859	active site
1091501006860	oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989
1091501006861	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
1091501006862	NAD binding site [chemical binding]; other site
1091501006863	catalytic Zn binding site [ion binding]; other site
1091501006864	substrate binding site [chemical binding]; other site
1091501006865	structural Zn binding site [ion binding]; other site
1091501006866	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
1091501006867	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
1091501006868	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
1091501006869	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
1091501006870	Protein of unknown function (DUF1298); Region: DUF1298; pfam06974
1091501006871	potential frameshift: common BLAST hit: gi|339633097|ref|YP_004724739.1| chain-fatty-acid-CoA ligase
1091501006872	SPFH domain / Band 7 family; Region: Band_7; pfam01145
1091501006873	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354
1091501006874	probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841
1091501006875	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
1091501006876	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1091501006877	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1091501006878	active site
1091501006879	potential frameshift: common BLAST hit: gi|339633103|ref|YP_004724745.1| transcriptional regulator
1091501006880	Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876
1091501006881	potential frameshift: common BLAST hit: gi|339633105|ref|YP_004724747.1| triacylglycerol lipase
1091501006882	De-etiolated protein 1 Det1; Region: Det1; pfam09737
1091501006883	PemK-like protein; Region: PemK; pfam02452
1091501006884	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
1091501006885	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
1091501006886	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
1091501006887	SmpB-tmRNA interface; other site
1091501006888	potential frameshift: common BLAST hit: gi|339633109|ref|YP_004724751.1| cell division protein FtsX
1091501006889	potential frameshift: common BLAST hit: gi|340628093|ref|YP_004746545.1| putative cell division ATP-binding protein FTSE
1091501006890	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1091501006891	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1091501006892	potential frameshift: common BLAST hit: gi|340628096|ref|YP_004746548.1| putative peptide chain release factor 2 PRFB (RF-2)
1091501006893	ferredoxin-NADP+ reductase; Region: PLN02852
1091501006894	ferredoxin-NADP+ reductase; Region: PLN02852
1091501006895	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1091501006896	FAD binding domain; Region: FAD_binding_4; pfam01565
1091501006897	Molybdenum cofactor biosynthesis enzyme [Coenzyme metabolism]; Region: MoaA; COG2896
1091501006898	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1091501006899	FeS/SAM binding site; other site
1091501006900	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
1091501006901	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488
1091501006902	aromatic arch; other site
1091501006903	DCoH dimer interaction site [polypeptide binding]; other site
1091501006904	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
1091501006905	DCoH tetramer interaction site [polypeptide binding]; other site
1091501006906	substrate binding site [chemical binding]; other site
1091501006907	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
1091501006908	trimer interface [polypeptide binding]; other site
1091501006909	dimer interface [polypeptide binding]; other site
1091501006910	putative active site [active]
1091501006911	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
1091501006912	MoaE interaction surface [polypeptide binding]; other site
1091501006913	MoeB interaction surface [polypeptide binding]; other site
1091501006914	thiocarboxylated glycine; other site
1091501006915	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
1091501006916	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
1091501006917	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
1091501006918	nucleoside/Zn binding site; other site
1091501006919	dimer interface [polypeptide binding]; other site
1091501006920	catalytic motif [active]
1091501006921	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1091501006922	MULE transposase domain; Region: MULE; pfam10551
1091501006923	molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878
1091501006924	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
1091501006925	ATP binding site [chemical binding]; other site
1091501006926	substrate interface [chemical binding]; other site
1091501006927	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1091501006928	active site residue [active]
1091501006929	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
1091501006930	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
1091501006931	active site residue [active]
1091501006932	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
1091501006933	active site residue [active]
1091501006934	Protein of unknown function (DUF1416); Region: DUF1416; pfam07210
1091501006935	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
1091501006936	MoaE homodimer interface [polypeptide binding]; other site
1091501006937	MoaD interaction [polypeptide binding]; other site
1091501006938	active site residues [active]
1091501006939	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1091501006940	S-adenosylmethionine binding site [chemical binding]; other site
1091501006941	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1091501006942	Cytochrome P450; Region: p450; cl12078
1091501006943	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943
1091501006944	DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629
1091501006945	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486
1091501006946	DNA binding site [nucleotide binding]
1091501006947	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1091501006948	PPE family; Region: PPE; pfam00823
1091501006949	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
1091501006950	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900
1091501006951	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
1091501006952	dimer interface [polypeptide binding]; other site
1091501006953	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
1091501006954	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1091501006955	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1091501006956	Histidine kinase; Region: HisKA_3; pfam07730
1091501006957	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1091501006958	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1091501006959	active site
1091501006960	phosphorylation site [posttranslational modification]
1091501006961	intermolecular recognition site; other site
1091501006962	dimerization interface [polypeptide binding]; other site
1091501006963	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1091501006964	DNA binding residues [nucleotide binding]
1091501006965	dimerization interface [polypeptide binding]; other site
1091501006966	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1091501006967	Ligand Binding Site [chemical binding]; other site
1091501006968	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1091501006969	PPE family; Region: PPE; pfam00823
1091501006970	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1091501006971	PPE family; Region: PPE; pfam00823
1091501006972	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
1091501006973	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1091501006974	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate,  or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
1091501006975	active site
1091501006976	AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337
1091501006977	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1091501006978	FeS/SAM binding site; other site
1091501006979	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1091501006980	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1091501006981	active site
1091501006982	potential frameshift: common BLAST hit: gi|339633147|ref|YP_004724789.1| acyl-CoA dehydrogenase
1091501006983	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1091501006984	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
1091501006985	NAD(P) binding site [chemical binding]; other site
1091501006986	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1091501006987	active site
1091501006988	phosphorylation site [posttranslational modification]
1091501006989	intermolecular recognition site; other site
1091501006990	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1091501006991	PPE family; Region: PPE; pfam00823
1091501006992	NADH dehydrogenase subunit A; Validated; Region: PRK07928
1091501006993	NADH dehydrogenase subunit B; Validated; Region: PRK06411
1091501006994	NADH dehydrogenase subunit C; Provisional; Region: PRK07785
1091501006995	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
1091501006996	potential frameshift: common BLAST hit: gi|340628124|ref|YP_004746576.1| putative NADH dehydrogenase I subunit D NuoD
1091501006997	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
1091501006998	putative dimer interface [polypeptide binding]; other site
1091501006999	[2Fe-2S] cluster binding site [ion binding]; other site
1091501007000	potential frameshift: common BLAST hit: gi|340628126|ref|YP_004746578.1| putative NADH dehydrogenase I subunit F NuoF
1091501007001	potential frameshift: common BLAST hit: gi|339633158|ref|YP_004724800.1| NADH dehydrogenase I subunit G
1091501007002	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
1091501007003	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
1091501007004	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
1091501007005	4Fe-4S binding domain; Region: Fer4; pfam00037
1091501007006	4Fe-4S binding domain; Region: Fer4; pfam00037
1091501007007	potential frameshift: common BLAST hit: gi|339633161|ref|YP_004724803.1| NADH dehydrogenase I subunit J
1091501007008	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
1091501007009	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
1091501007010	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
1091501007011	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1091501007012	potential frameshift: common BLAST hit: gi|15842733|ref|NP_337770.1| NADH dehydrogenase subunit M
1091501007013	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
1091501007014	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1091501007015	potential frameshift: common BLAST hit: gi|15842735|ref|NP_337772.1| PPE family protein
1091501007016	pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613
1091501007017	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1091501007018	potential frameshift: common BLAST hit: gi|339633169|ref|YP_004724811.1| dioxygenase
1091501007019	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
1091501007020	Protein of unknown function DUF58; Region: DUF58; pfam01882
1091501007021	MoxR-like ATPases [General function prediction only]; Region: COG0714
1091501007022	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1091501007023	Walker A motif; other site
1091501007024	ATP binding site [chemical binding]; other site
1091501007025	Walker B motif; other site
1091501007026	arginine finger; other site
1091501007027	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
1091501007028	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1091501007029	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1091501007030	potential frameshift: common BLAST hit: gi|339633178|ref|YP_004724820.1| amine oxidase
1091501007031	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1091501007032	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1091501007033	short chain dehydrogenase; Validated; Region: PRK08264
1091501007034	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1091501007035	NAD(P) binding site [chemical binding]; other site
1091501007036	active site
1091501007037	potential frameshift: common BLAST hit: gi|253800209|ref|YP_003033210.1| amidase
1091501007038	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1091501007039	potential frameshift: common BLAST hit: gi|15842754|ref|NP_337791.1| alpha/beta hydrolase
1091501007040	Domain of unknown function (DUF385); Region: DUF385; pfam04075
1091501007041	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
1091501007042	putative active site [active]
1091501007043	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
1091501007044	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4683
1091501007045	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1091501007046	non-specific DNA binding site [nucleotide binding]; other site
1091501007047	salt bridge; other site
1091501007048	sequence-specific DNA binding site [nucleotide binding]; other site
1091501007049	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1091501007050	Transposase; Region: HTH_Tnp_1; cl17663
1091501007051	HTH-like domain; Region: HTH_21; pfam13276
1091501007052	Integrase core domain; Region: rve; pfam00665
1091501007053	putative transposase OrfB; Reviewed; Region: PHA02517
1091501007054	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1091501007055	Transposase; Region: HTH_Tnp_1; cl17663
1091501007056	putative transposase OrfB; Reviewed; Region: PHA02517
1091501007057	HTH-like domain; Region: HTH_21; pfam13276
1091501007058	Integrase core domain; Region: rve; pfam00665
1091501007059	Integrase core domain; Region: rve_3; pfam13683
1091501007060	RES domain; Region: RES; pfam08808
1091501007061	potential frameshift: common BLAST hit: gi|253800222|ref|YP_003033223.1| transposase
1091501007062	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
1091501007063	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1091501007064	Uncharacterized conserved protein [Function unknown]; Region: COG1615
1091501007065	Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133
1091501007066	ABC1 family; Region: ABC1; pfam03109
1091501007067	Phosphotransferase enzyme family; Region: APH; pfam01636
1091501007068	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
1091501007069	active site
1091501007070	ATP binding site [chemical binding]; other site
1091501007071	Transcription factor WhiB; Region: Whib; pfam02467
1091501007072	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
1091501007073	Part of AAA domain; Region: AAA_19; pfam13245
1091501007074	Family description; Region: UvrD_C_2; pfam13538
1091501007075	HRDC domain; Region: HRDC; pfam00570
1091501007076	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
1091501007077	catalytic residues [active]
1091501007078	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
1091501007079	putative NADH binding site [chemical binding]; other site
1091501007080	putative active site [active]
1091501007081	nudix motif; other site
1091501007082	putative metal binding site [ion binding]; other site
1091501007083	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
1091501007084	Ion channel; Region: Ion_trans_2; pfam07885
1091501007085	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
1091501007086	TrkA-N domain; Region: TrkA_N; pfam02254
1091501007087	potential frameshift: common BLAST hit: gi|339633208|ref|YP_004724850.1| ATP-dependent DNA helicase
1091501007088	potential frameshift: common BLAST hit: gi|339633208|ref|YP_004724850.1| ATP-dependent DNA helicase
1091501007089	potential frameshift: common BLAST hit: gi|340628179|ref|YP_004746631.1| putative ATP-dependent DNA helicase
1091501007090	potential frameshift: common BLAST hit: gi|340628179|ref|YP_004746631.1| putative ATP-dependent DNA helicase
1091501007091	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
1091501007092	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
1091501007093	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1091501007094	active site
1091501007095	DNA binding site [nucleotide binding]
1091501007096	TIGR02569 family protein; Region: TIGR02569_actnb
1091501007097	potential frameshift: common BLAST hit: gi|339633213|ref|YP_004724855.1| molybdenum cofactor biosynthesis protein B
1091501007098	Protein of unknown function (DUF3152); Region: DUF3152; pfam11350
1091501007099	Protein of unknown function (DUF3107); Region: DUF3107; pfam11305
1091501007100	tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like; Region: MiaE_2; pfam13794
1091501007101	potential frameshift: common BLAST hit: gi|340628189|ref|YP_004746641.1| putative ATP-dependent RNA HELICASE RHLE
1091501007102	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1091501007103	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1091501007104	P-loop; other site
1091501007105	Magnesium ion binding site [ion binding]; other site
1091501007106	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1091501007107	Magnesium ion binding site [ion binding]; other site
1091501007108	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1091501007109	catalytic core [active]
1091501007110	Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169
1091501007111	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
1091501007112	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
1091501007113	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
1091501007114	Transcription factor WhiB; Region: Whib; pfam02467
1091501007115	Signal transduction histidine kinase; Region: H_kinase_N; pfam12282
1091501007116	PAS domain S-box; Region: sensory_box; TIGR00229
1091501007117	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
1091501007118	Histidine kinase; Region: HisKA_2; pfam07568
1091501007119	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1091501007120	ATP binding site [chemical binding]; other site
1091501007121	Mg2+ binding site [ion binding]; other site
1091501007122	G-X-G motif; other site
1091501007123	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1091501007124	carboxyltransferase (CT) interaction site; other site
1091501007125	biotinylation site [posttranslational modification]; other site
1091501007126	mycothiol system anti-sigma-R factor; Region: antisig_RsrA; TIGR03988
1091501007127	RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939
1091501007128	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1091501007129	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1091501007130	DNA binding residues [nucleotide binding]
1091501007131	short chain dehydrogenase; Provisional; Region: PRK08278
1091501007132	human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762
1091501007133	NAD(P) binding site [chemical binding]; other site
1091501007134	homodimer interface [polypeptide binding]; other site
1091501007135	active site
1091501007136	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022
1091501007137	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022
1091501007138	putative deacylase active site [active]
1091501007139	potential frameshift: common BLAST hit: gi|339633236|ref|YP_004724878.1| transferase
1091501007140	Uncharacterized conserved protein [Function unknown]; Region: COG2135
1091501007141	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
1091501007142	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
1091501007143	hinge; other site
1091501007144	active site
1091501007145	potential frameshift: common BLAST hit: gi|339633240|ref|YP_004724882.1| linoleoyl-CoA desaturase
1091501007146	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216
1091501007147	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
1091501007148	FAD binding pocket [chemical binding]; other site
1091501007149	FAD binding motif [chemical binding]; other site
1091501007150	phosphate binding motif [ion binding]; other site
1091501007151	beta-alpha-beta structure motif; other site
1091501007152	NAD binding pocket [chemical binding]; other site
1091501007153	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1091501007154	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
1091501007155	catalytic loop [active]
1091501007156	iron binding site [ion binding]; other site
1091501007157	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
1091501007158	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
1091501007159	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
1091501007160	Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490
1091501007161	TrkA-C domain; Region: TrkA_C; pfam02080
1091501007162	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
1091501007163	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1091501007164	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1091501007165	putative substrate translocation pore; other site
1091501007166	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1091501007167	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1091501007168	ligand binding site [chemical binding]; other site
1091501007169	flexible hinge region; other site
1091501007170	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
1091501007171	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
1091501007172	nucleophile elbow; other site
1091501007173	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
1091501007174	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
1091501007175	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
1091501007176	30S subunit binding site; other site
1091501007177	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
1091501007178	active site
1091501007179	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309
1091501007180	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
1091501007181	potential frameshift: common BLAST hit: gi|253800286|ref|YP_003033287.1| lipoprotein LpqB
1091501007182	potential frameshift: common BLAST hit: gi|340628223|ref|YP_004746675.1| two component sensorY transduction histidine kinase MTRB
1091501007183	potential frameshift: common BLAST hit: gi|148663108|ref|YP_001284631.1| two component sensory transduction histidine kinase MtrB
1091501007184	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1091501007185	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1091501007186	active site
1091501007187	phosphorylation site [posttranslational modification]
1091501007188	intermolecular recognition site; other site
1091501007189	dimerization interface [polypeptide binding]; other site
1091501007190	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1091501007191	DNA binding site [nucleotide binding]
1091501007192	Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125
1091501007193	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
1091501007194	TMP-binding site; other site
1091501007195	ATP-binding site [chemical binding]; other site
1091501007196	Adenosylhomocysteinase; Provisional; Region: PTZ00075
1091501007197	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
1091501007198	homotetramer interface [polypeptide binding]; other site
1091501007199	ligand binding site [chemical binding]; other site
1091501007200	catalytic site [active]
1091501007201	NAD binding site [chemical binding]; other site
1091501007202	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1091501007203	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
1091501007204	Rubredoxin [Energy production and conversion]; Region: COG1773
1091501007205	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
1091501007206	iron binding site [ion binding]; other site
1091501007207	Rubredoxin [Energy production and conversion]; Region: COG1773
1091501007208	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
1091501007209	iron binding site [ion binding]; other site
1091501007210	potential frameshift: common BLAST hit: gi|339633262|ref|YP_004724904.1| alkane 1-monooxygenase
1091501007211	potential frameshift: common BLAST hit: gi|340628231|ref|YP_004746683.1| putative cationic amino acid transport integral membrane protein
1091501007212	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
1091501007213	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
1091501007214	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
1091501007215	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
1091501007216	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
1091501007217	phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542
1091501007218	active site
1091501007219	substrate binding site [chemical binding]; other site
1091501007220	metal binding site [ion binding]; metal-binding site
1091501007221	Protein of unknown function (DUF3499); Region: DUF3499; pfam12005
1091501007222	Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954
1091501007223	Transcription factor WhiB; Region: Whib; pfam02467
1091501007224	Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933
1091501007225	LPPG:FO 2-phospho-L-lactate transferase; important in F420 biosynthesis; Region: CofD_like; cd07186
1091501007226	phosphate binding site [ion binding]; other site
1091501007227	dimer interface [polypeptide binding]; other site
1091501007228	substrate binding site [chemical binding]; other site
1091501007229	F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294
1091501007230	F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644
1091501007231	NAD(P)H:flavin oxidoreductase-like family 1.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150
1091501007232	putative FMN binding site [chemical binding]; other site
1091501007233	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827
1091501007234	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
1091501007235	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
1091501007236	active site
1091501007237	Substrate binding site; other site
1091501007238	Mg++ binding site; other site
1091501007239	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
1091501007240	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
1091501007241	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1091501007242	Probable Catalytic site; other site
1091501007243	metal-binding site
1091501007244	dTDP-4-dehydrorhamnose reductase; Region: rmlD; TIGR01214
1091501007245	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
1091501007246	NADP binding site [chemical binding]; other site
1091501007247	active site
1091501007248	putative substrate binding site [chemical binding]; other site
1091501007249	Transcriptional regulator [Transcription]; Region: LytR; COG1316
1091501007250	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
1091501007251	TIGR03089 family protein; Region: TIGR03089
1091501007252	Protein of unknown function (DUF1490); Region: DUF1490; pfam07371
1091501007253	potential frameshift: common BLAST hit: gi|339633280|ref|YP_004724922.1| ATPase P
1091501007254	potential frameshift: common BLAST hit: gi|340628248|ref|YP_004746700.1| putative metal cation-transporting p-type ATPase c
1091501007255	potential frameshift: common BLAST hit: gi|339633280|ref|YP_004724922.1| ATPase P
1091501007256	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
1091501007257	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
1091501007258	CoA-transferase family III; Region: CoA_transf_3; pfam02515
1091501007259	Sulfate transporter family; Region: Sulfate_transp; pfam00916
1091501007260	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
1091501007261	Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: CynT; COG0288
1091501007262	active site clefts [active]
1091501007263	zinc binding site [ion binding]; other site
1091501007264	dimer interface [polypeptide binding]; other site
1091501007265	potential frameshift: common BLAST hit: gi|339633284|ref|YP_004724926.1| acyl-CoA dehydrogenase
1091501007266	AIR carboxylase; Region: AIRC; cl00310
1091501007267	AIR carboxylase; Region: AIRC; pfam00731
1091501007268	Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase) [Nucleotide transport and metabolism]; Region: PurK; COG0026
1091501007269	ATP-grasp domain; Region: ATP-grasp; pfam02222
1091501007270	Predicted membrane protein [Function unknown]; Region: COG2246
1091501007271	GtrA-like protein; Region: GtrA; pfam04138
1091501007272	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
1091501007273	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
1091501007274	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
1091501007275	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
1091501007276	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
1091501007277	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
1091501007278	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
1091501007279	Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822
1091501007280	Maf-like protein; Region: Maf; pfam02545
1091501007281	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
1091501007282	active site
1091501007283	dimer interface [polypeptide binding]; other site
1091501007284	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
1091501007285	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
1091501007286	active site residue [active]
1091501007287	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
1091501007288	active site residue [active]
1091501007289	Fe-S metabolism associated domain; Region: SufE; pfam02657
1091501007290	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
1091501007291	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1091501007292	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1091501007293	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1091501007294	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1091501007295	carboxyltransferase (CT) interaction site; other site
1091501007296	biotinylation site [posttranslational modification]; other site
1091501007297	RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122
1091501007298	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1091501007299	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1091501007300	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
1091501007301	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
1091501007302	potential frameshift: common BLAST hit: gi|339633299|ref|YP_004724941.1| L-lysine-epsilon aminotransferase
1091501007303	potential frameshift: common BLAST hit: gi|340628272|ref|YP_004746724.1| putative L-lysine-epsilon aminotransferase
1091501007304	putative DNA binding site [nucleotide binding]; other site
1091501007305	dimerization interface [polypeptide binding]; other site
1091501007306	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
1091501007307	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
1091501007308	putative Zn2+ binding site [ion binding]; other site
1091501007309	AsnC family; Region: AsnC_trans_reg; pfam01037
1091501007310	Domain of unknown function (DUF1338); Region: DUF1338; pfam07063
1091501007311	potential frameshift: common BLAST hit: gi|339633302|ref|YP_004724944.1| piperideine-6-carboxilic acid dehydrogenase
1091501007312	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
1091501007313	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1091501007314	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1091501007315	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1091501007316	putative Mg++ binding site [ion binding]; other site
1091501007317	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1091501007318	nucleotide binding region [chemical binding]; other site
1091501007319	ATP-binding site [chemical binding]; other site
1091501007320	putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751
1091501007321	DEAD/H associated; Region: DEAD_assoc; pfam08494
1091501007322	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
1091501007323	N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971
1091501007324	putative DNA binding site [nucleotide binding]; other site
1091501007325	catalytic residue [active]
1091501007326	putative H2TH interface [polypeptide binding]; other site
1091501007327	putative catalytic residues [active]
1091501007328	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
1091501007329	Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509
1091501007330	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1091501007331	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
1091501007332	Sulfatase; Region: Sulfatase; cl17466
1091501007333	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
1091501007334	potential frameshift: common BLAST hit: gi|224991681|ref|YP_002646370.1| arylsulfatase
1091501007335	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
1091501007336	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1091501007337	active site
1091501007338	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
1091501007339	PhoU domain; Region: PhoU; pfam01895
1091501007340	PhoU domain; Region: PhoU; pfam01895
1091501007341	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
1091501007342	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1091501007343	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1091501007344	potential frameshift: common BLAST hit: gi|339633312|ref|YP_004724954.1| N-acyl-L-amino acid amidohydrolase
1091501007345	M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672
1091501007346	amidohydrolase; Region: amidohydrolases; TIGR01891
1091501007347	metal binding site [ion binding]; metal-binding site
1091501007348	purine nucleoside phosphorylase; Provisional; Region: PRK08202
1091501007349	potential frameshift: common BLAST hit: gi|253800351|ref|YP_003033352.1| phosphomannomutase pmmB
1091501007350	The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757
1091501007351	substrate binding site [chemical binding]; other site
1091501007352	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1091501007353	active site
1091501007354	Phosphoesterase family; Region: Phosphoesterase; pfam04185
1091501007355	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
1091501007356	adenosine deaminase; Provisional; Region: PRK09358
1091501007357	active site
1091501007358	potential frameshift: common BLAST hit: gi|253800359|ref|YP_003033360.1| thymidine phosphorylase
1091501007359	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
1091501007360	active site
1091501007361	catalytic motif [active]
1091501007362	Zn binding site [ion binding]; other site
1091501007363	Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501
1091501007364	putative Iron-sulfur protein interface [polypeptide binding]; other site
1091501007365	putative proximal heme binding site [chemical binding]; other site
1091501007366	putative SdhD-like interface [polypeptide binding]; other site
1091501007367	putative distal heme binding site [chemical binding]; other site
1091501007368	Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500
1091501007369	putative Iron-sulfur protein interface [polypeptide binding]; other site
1091501007370	putative proximal heme binding site [chemical binding]; other site
1091501007371	putative SdhC-like subunit interface [polypeptide binding]; other site
1091501007372	putative distal heme binding site [chemical binding]; other site
1091501007373	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205
1091501007374	L-aspartate oxidase; Provisional; Region: PRK06175
1091501007375	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
1091501007376	potential frameshift: common BLAST hit: gi|340628303|ref|YP_004746755.1| putative succinate dehydrogenase iron-sulfur protein subunit SDHB
1091501007377	Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028
1091501007378	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1091501007379	S-adenosylmethionine binding site [chemical binding]; other site
1091501007380	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
1091501007381	MoaE interaction surface [polypeptide binding]; other site
1091501007382	MoeB interaction surface [polypeptide binding]; other site
1091501007383	thiocarboxylated glycine; other site
1091501007384	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
1091501007385	MoaE homodimer interface [polypeptide binding]; other site
1091501007386	MoaD interaction [polypeptide binding]; other site
1091501007387	active site residues [active]
1091501007388	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
1091501007389	trimer interface [polypeptide binding]; other site
1091501007390	dimer interface [polypeptide binding]; other site
1091501007391	putative active site [active]
1091501007392	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1091501007393	Transposase; Region: HTH_Tnp_1; cl17663
1091501007394	putative transposase OrfB; Reviewed; Region: PHA02517
1091501007395	HTH-like domain; Region: HTH_21; pfam13276
1091501007396	Integrase core domain; Region: rve; pfam00665
1091501007397	Integrase core domain; Region: rve_3; pfam13683
1091501007398	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
1091501007399	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1091501007400	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
1091501007401	Uncharacterized conserved protein [Function unknown]; Region: COG2128
1091501007402	potential frameshift: common BLAST hit: gi|340628313|ref|YP_004746765.1| putative alternative RNA polymerase sigma factor
1091501007403	hypothetical protein; Provisional; Region: PRK06541
1091501007404	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1091501007405	inhibitor-cofactor binding pocket; inhibition site
1091501007406	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1091501007407	catalytic residue [active]
1091501007408	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1091501007409	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
1091501007410	potential frameshift: common BLAST hit: gi|340628316|ref|YP_004746768.1| putative sugar-transport integral membrane protein SUGI
1091501007411	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
1091501007412	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
1091501007413	active site
1091501007414	dimer interface [polypeptide binding]; other site
1091501007415	Protein of unknown function (DUF732); Region: DUF732; pfam05305
1091501007416	Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770
1091501007417	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1091501007418	DNA binding residues [nucleotide binding]
1091501007419	dimer interface [polypeptide binding]; other site
1091501007420	metal binding site [ion binding]; metal-binding site
1091501007421	inner membrane protein YhjD; Region: TIGR00766
1091501007422	potential frameshift: common BLAST hit: gi|339633348|ref|YP_004724990.1| tryptophanyl-tRNA synthetase
1091501007423	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1091501007424	potential frameshift: common BLAST hit: gi|339633350|ref|YP_004724992.1| isocitrate dehydrogenase [NADP]
1091501007425	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
1091501007426	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
1091501007427	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1091501007428	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1091501007429	S-adenosylmethionine binding site [chemical binding]; other site
1091501007430	potential frameshift: common BLAST hit: gi|57117092|ref|YP_177960.1| PPE family protein
1091501007431	potential frameshift: common BLAST hit: gi|339633354|ref|YP_004724996.1| PPE family protein
1091501007432	PPE family; Region: PPE; pfam00823
1091501007433	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1091501007434	PE family; Region: PE; pfam00934
1091501007435	Protein of unknown function (DUF3017); Region: DUF3017; pfam11222
1091501007436	potential frameshift: common BLAST hit: gi|148663209|ref|YP_001284732.1| PPE family protein
1091501007437	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1091501007438	Transposase; Region: DDE_Tnp_ISL3; pfam01610
1091501007439	potential frameshift: common BLAST hit: gi|57117096|ref|YP_177964.1| PPE family protein
1091501007440	potential frameshift: common BLAST hit: gi|253800397|ref|YP_003033398.1| PPE family protein
1091501007441	potential frameshift: common BLAST hit: gi|57117096|ref|YP_177964.1| PPE family protein
1091501007442	potential frameshift: common BLAST hit: gi|57117096|ref|YP_177964.1| PPE family protein
1091501007443	Berberine and berberine like; Region: BBE; pfam08031
1091501007444	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1091501007445	Protein of unknown function (DUF732); Region: DUF732; pfam05305
1091501007446	Protein of unknown function (DUF3017); Region: DUF3017; pfam11222
1091501007447	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193
1091501007448	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
1091501007449	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
1091501007450	homodimer interface [polypeptide binding]; other site
1091501007451	NADP binding site [chemical binding]; other site
1091501007452	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161
1091501007453	Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769
1091501007454	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1091501007455	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
1091501007456	active site
1091501007457	FMN binding site [chemical binding]; other site
1091501007458	substrate binding site [chemical binding]; other site
1091501007459	putative catalytic residue [active]
1091501007460	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1091501007461	phosphate binding site [ion binding]; other site
1091501007462	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
1091501007463	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1091501007464	phosphopeptide binding site; other site
1091501007465	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
1091501007466	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1091501007467	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
1091501007468	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1091501007469	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
1091501007470	Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029
1091501007471	G1 box; other site
1091501007472	GTP/Mg2+ binding site [chemical binding]; other site
1091501007473	G2 box; other site
1091501007474	Switch I region; other site
1091501007475	G3 box; other site
1091501007476	Switch II region; other site
1091501007477	G4 box; other site
1091501007478	G5 box; other site
1091501007479	Protein of unknown function (DUF742); Region: DUF742; pfam05331
1091501007480	Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018
1091501007481	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1091501007482	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1091501007483	ATP binding site [chemical binding]; other site
1091501007484	Mg2+ binding site [ion binding]; other site
1091501007485	G-X-G motif; other site
1091501007486	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
1091501007487	potential frameshift: common BLAST hit: gi|340628349|ref|YP_004746801.1| PE-PGRS family protein
1091501007488	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062
1091501007489	FMN binding site [chemical binding]; other site
1091501007490	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
1091501007491	potential frameshift: common BLAST hit: gi|161511527|ref|NP_857046.2| error-prone DNA polymerase
1091501007492	potential frameshift: common BLAST hit: gi|161511527|ref|NP_857046.2| error-prone DNA polymerase
1091501007493	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
1091501007494	Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877
1091501007495	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1091501007496	active site
1091501007497	motif I; other site
1091501007498	motif II; other site
1091501007499	PE family; Region: PE; pfam00934
1091501007500	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
1091501007501	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1091501007502	substrate binding site [chemical binding]; other site
1091501007503	oxyanion hole (OAH) forming residues; other site
1091501007504	trimer interface [polypeptide binding]; other site
1091501007505	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
1091501007506	Amidase; Region: Amidase; pfam01425
1091501007507	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
1091501007508	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1091501007509	motif II; other site
1091501007510	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267
1091501007511	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688
1091501007512	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
1091501007513	TPP-binding site [chemical binding]; other site
1091501007514	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
1091501007515	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1091501007516	PYR/PP interface [polypeptide binding]; other site
1091501007517	dimer interface [polypeptide binding]; other site
1091501007518	TPP binding site [chemical binding]; other site
1091501007519	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1091501007520	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
1091501007521	putative transposase OrfB; Reviewed; Region: PHA02517
1091501007522	HTH-like domain; Region: HTH_21; pfam13276
1091501007523	Integrase core domain; Region: rve; pfam00665
1091501007524	Integrase core domain; Region: rve_3; pfam13683
1091501007525	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1091501007526	Transposase; Region: HTH_Tnp_1; cl17663
1091501007527	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
1091501007528	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
1091501007529	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1091501007530	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1091501007531	substrate binding pocket [chemical binding]; other site
1091501007532	chain length determination region; other site
1091501007533	substrate-Mg2+ binding site; other site
1091501007534	catalytic residues [active]
1091501007535	aspartate-rich region 1; other site
1091501007536	active site lid residues [active]
1091501007537	aspartate-rich region 2; other site
1091501007538	PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874
1091501007539	putative active site [active]
1091501007540	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
1091501007541	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
1091501007542	Transposase domain (DUF772); Region: DUF772; pfam05598
1091501007543	potential frameshift: common BLAST hit: gi|253800433|ref|YP_003033434.1| transposase
1091501007544	PE family; Region: PE; pfam00934
1091501007545	enoyl-CoA hydratase; Region: PLN02864
1091501007546	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
1091501007547	HDE_HSD  The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins.  Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448
1091501007548	dimer interaction site [polypeptide binding]; other site
1091501007549	substrate-binding tunnel; other site
1091501007550	active site
1091501007551	catalytic site [active]
1091501007552	substrate binding site [chemical binding]; other site
1091501007553	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1091501007554	short chain dehydrogenase; Provisional; Region: PRK07201
1091501007555	Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263
1091501007556	putative NAD(P) binding site [chemical binding]; other site
1091501007557	active site
1091501007558	putative substrate binding site [chemical binding]; other site
1091501007559	classical (c) SDRs; Region: SDR_c; cd05233
1091501007560	NAD(P) binding site [chemical binding]; other site
1091501007561	active site
1091501007562	potential frameshift: common BLAST hit: gi|339633397|ref|YP_004725039.1| cyclopropane fatty acid synthase
1091501007563	NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653
1091501007564	GMP synthase; Reviewed; Region: guaA; PRK00074
1091501007565	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
1091501007566	AMP/PPi binding site [chemical binding]; other site
1091501007567	candidate oxyanion hole; other site
1091501007568	catalytic triad [active]
1091501007569	potential glutamine specificity residues [chemical binding]; other site
1091501007570	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
1091501007571	ATP Binding subdomain [chemical binding]; other site
1091501007572	Ligand Binding sites [chemical binding]; other site
1091501007573	Dimerization subdomain; other site
1091501007574	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
1091501007575	active site lid residues [active]
1091501007576	substrate binding pocket [chemical binding]; other site
1091501007577	catalytic residues [active]
1091501007578	substrate-Mg2+ binding site; other site
1091501007579	aspartate-rich region 1; other site
1091501007580	aspartate-rich region 2; other site
1091501007581	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1091501007582	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1091501007583	substrate binding pocket [chemical binding]; other site
1091501007584	chain length determination region; other site
1091501007585	substrate-Mg2+ binding site; other site
1091501007586	catalytic residues [active]
1091501007587	aspartate-rich region 1; other site
1091501007588	active site lid residues [active]
1091501007589	aspartate-rich region 2; other site
1091501007590	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
1091501007591	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
1091501007592	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
1091501007593	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
1091501007594	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
1091501007595	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
1091501007596	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
1091501007597	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
1091501007598	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
1091501007599	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
1091501007600	inhibitor-cofactor binding pocket; inhibition site
1091501007601	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1091501007602	catalytic residue [active]
1091501007603	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529
1091501007604	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1091501007605	hypothetical protein; Provisional; Region: PRK07579
1091501007606	Formyltransferase, catalytic core domain; Region: FMT_core; cd08369
1091501007607	active site
1091501007608	cosubstrate binding site; other site
1091501007609	substrate binding site [chemical binding]; other site
1091501007610	catalytic site [active]
1091501007611	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1091501007612	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1091501007613	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
1091501007614	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
1091501007615	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
1091501007616	PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874
1091501007617	putative active site [active]
1091501007618	potential frameshift: common BLAST hit: gi|339633414|ref|YP_004725056.1| cholesterol oxidase
1091501007619	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649
1091501007620	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1091501007621	phosphate binding site [ion binding]; other site
1091501007622	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
1091501007623	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1091501007624	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
1091501007625	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
1091501007626	active site
1091501007627	RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648
1091501007628	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1091501007629	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
1091501007630	DNA binding residues [nucleotide binding]
1091501007631	Transcription factor WhiB; Region: Whib; pfam02467
1091501007632	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
1091501007633	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
1091501007634	ring oligomerisation interface [polypeptide binding]; other site
1091501007635	ATP/Mg binding site [chemical binding]; other site
1091501007636	stacking interactions; other site
1091501007637	hinge regions; other site
1091501007638	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
1091501007639	oligomerisation interface [polypeptide binding]; other site
1091501007640	mobile loop; other site
1091501007641	roof hairpin; other site
1091501007642	UGMP family protein; Validated; Region: PRK09604
1091501007643	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
1091501007644	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1091501007645	Coenzyme A binding pocket [chemical binding]; other site
1091501007646	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214
1091501007647	Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; pfam02367
1091501007648	potential frameshift: common BLAST hit: gi|339633428|ref|YP_004725070.1| alanine racemase
1091501007649	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1091501007650	PPE family; Region: PPE; pfam00823
1091501007651	potential frameshift: common BLAST hit: gi|339633431|ref|YP_004725073.1| transposase
1091501007652	potential frameshift: common BLAST hit: gi|148824633|ref|YP_001289387.1| transposase
1091501007653	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1091501007654	PPE family; Region: PPE; pfam00823
1091501007655	Integrase core domain; Region: rve; pfam00665
1091501007656	Integrase core domain; Region: rve_3; pfam13683
1091501007657	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1091501007658	MULE transposase domain; Region: MULE; pfam10551
1091501007659	DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450
1091501007660	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1091501007661	catalytic residue [active]
1091501007662	potential frameshift: common BLAST hit: gi|224991852|ref|YP_002646541.1| transmembrane protein
1091501007663	potential frameshift: common BLAST hit: gi|339633441|ref|YP_004725083.1| glucosamine--fructose-6-phosphate aminotransferase
1091501007664	Protein of unknown function (DUF2510); Region: DUF2510; pfam10708
1091501007665	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318
1091501007666	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
1091501007667	active site
1091501007668	substrate binding site [chemical binding]; other site
1091501007669	metal binding site [ion binding]; metal-binding site
1091501007670	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
1091501007671	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
1091501007672	23S rRNA interface [nucleotide binding]; other site
1091501007673	L3 interface [polypeptide binding]; other site
1091501007674	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842
1091501007675	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842
1091501007676	type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931
1091501007677	type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920
1091501007678	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
1091501007679	type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921
1091501007680	active site
1091501007681	catalytic residues [active]
1091501007682	Cutinase; Region: Cutinase; pfam01083
1091501007683	Cutinase; Region: Cutinase; pfam01083
1091501007684	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
1091501007685	potential frameshift: common BLAST hit: gi|253800500|ref|YP_003033501.1| tRNA pseudouridine synthase A
1091501007686	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
1091501007687	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
1091501007688	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
1091501007689	alphaNTD - beta interaction site [polypeptide binding]; other site
1091501007690	alphaNTD homodimer interface [polypeptide binding]; other site
1091501007691	alphaNTD - beta' interaction site [polypeptide binding]; other site
1091501007692	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
1091501007693	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
1091501007694	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
1091501007695	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1091501007696	RNA binding surface [nucleotide binding]; other site
1091501007697	30S ribosomal protein S11; Validated; Region: PRK05309
1091501007698	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
1091501007699	30S ribosomal protein S13; Region: bact_S13; TIGR03631
1091501007700	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
1091501007701	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
1091501007702	rRNA binding site [nucleotide binding]; other site
1091501007703	predicted 30S ribosome binding site; other site
1091501007704	probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620
1091501007705	F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564
1091501007706	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
1091501007707	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
1091501007708	NAD binding site [chemical binding]; other site
1091501007709	substrate binding site [chemical binding]; other site
1091501007710	homodimer interface [polypeptide binding]; other site
1091501007711	active site
1091501007712	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405
1091501007713	Domain of unknown function (DUF222); Region: DUF222; pfam02720
1091501007714	Domain of unknown function (DUF222); Region: DUF222; pfam02720
1091501007715	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1091501007716	active site
1091501007717	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1091501007718	extended (e) SDRs; Region: SDR_e; cd08946
1091501007719	NAD(P) binding site [chemical binding]; other site
1091501007720	active site
1091501007721	potential frameshift: common BLAST hit: gi|339633474|ref|YP_004725116.1| 4-hydroxy-2-oxovalerate aldolase
1091501007722	potential protein location (hypothetical protein) that overlaps protein (4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase)
1091501007723	potential frameshift: common BLAST hit: gi|253800515|ref|YP_003033516.1| acetolactate synthase large subunit ilvB2
1091501007724	Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662
1091501007725	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531
1091501007726	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1091501007727	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
1091501007728	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1091501007729	Transposase; Region: HTH_Tnp_1; cl17663
1091501007730	putative transposase OrfB; Reviewed; Region: PHA02517
1091501007731	HTH-like domain; Region: HTH_21; pfam13276
1091501007732	Integrase core domain; Region: rve; pfam00665
1091501007733	Integrase core domain; Region: rve_3; pfam13683
1091501007734	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1091501007735	metabolite-proton symporter; Region: 2A0106; TIGR00883
1091501007736	putative substrate translocation pore; other site
1091501007737	PE family; Region: PE; pfam00934
1091501007738	potential frameshift: common BLAST hit: gi|253800521|ref|YP_003033522.1| PPE family protein
1091501007739	patatin-related protein; Region: TIGR03607
1091501007740	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
1091501007741	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
1091501007742	Protein of unknown function (DUF1298); Region: DUF1298; pfam06974
1091501007743	Protein of unknown function (DUF2910); Region: DUF2910; pfam11139
1091501007744	Protein of unknown function (DUF2510); Region: DUF2510; pfam10708
1091501007745	LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041
1091501007746	Transcriptional regulator [Transcription]; Region: LytR; COG1316
1091501007747	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
1091501007748	short chain dehydrogenase; Provisional; Region: PRK05875
1091501007749	classical (c) SDRs; Region: SDR_c; cd05233
1091501007750	NAD(P) binding site [chemical binding]; other site
1091501007751	active site
1091501007752	Predicted membrane protein [Function unknown]; Region: COG2259
1091501007753	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
1091501007754	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1091501007755	Predicted transcriptional regulators [Transcription]; Region: COG1695
1091501007756	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
1091501007757	Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380
1091501007758	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
1091501007759	active site
1091501007760	homotetramer interface [polypeptide binding]; other site
1091501007761	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
1091501007762	mce related protein; Region: MCE; pfam02470
1091501007763	potential frameshift: common BLAST hit: gi|253800537|ref|YP_003033538.1| MCE-family lipoprotein mce4E
1091501007764	potential frameshift: common BLAST hit: gi|253800538|ref|YP_003033539.1| MCE-family protein mce4D
1091501007765	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
1091501007766	mce related protein; Region: MCE; pfam02470
1091501007767	potential frameshift: common BLAST hit: gi|340628466|ref|YP_004746918.1| MCE-family protein MCE4B
1091501007768	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
1091501007769	mce related protein; Region: MCE; pfam02470
1091501007770	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
1091501007771	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
1091501007772	Permease; Region: Permease; pfam02405
1091501007773	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
1091501007774	Permease; Region: Permease; pfam02405
1091501007775	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1091501007776	NAD(P) binding site [chemical binding]; other site
1091501007777	active site
1091501007778	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
1091501007779	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
1091501007780	potential frameshift: common BLAST hit: gi|339633507|ref|YP_004725149.1| acyl-CoA dehydrogenase
1091501007781	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1091501007782	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1091501007783	active site
1091501007784	acyl-CoA synthetase; Validated; Region: PRK07867
1091501007785	Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940
1091501007786	acyl-activating enzyme (AAE) consensus motif; other site
1091501007787	putative AMP binding site [chemical binding]; other site
1091501007788	putative active site [active]
1091501007789	putative CoA binding site [chemical binding]; other site
1091501007790	PE family; Region: PE; pfam00934
1091501007791	PE family; Region: PE; pfam00934
1091501007792	hypothetical protein; Validated; Region: PRK07586
1091501007793	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1091501007794	PYR/PP interface [polypeptide binding]; other site
1091501007795	dimer interface [polypeptide binding]; other site
1091501007796	TPP binding site [chemical binding]; other site
1091501007797	Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002
1091501007798	TPP-binding site [chemical binding]; other site
1091501007799	dimer interface [polypeptide binding]; other site
1091501007800	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159
1091501007801	PE family; Region: PE; pfam00934
1091501007802	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1091501007803	CoA binding site [chemical binding]; other site
1091501007804	PE family; Region: PE; pfam00934
1091501007805	potential frameshift: common BLAST hit: gi|339633515|ref|YP_004725157.1| fatty-acid-CoA ligase
1091501007806	enoyl-CoA hydratase; Provisional; Region: PRK07799
1091501007807	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1091501007808	substrate binding site [chemical binding]; other site
1091501007809	oxyanion hole (OAH) forming residues; other site
1091501007810	trimer interface [polypeptide binding]; other site
1091501007811	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
1091501007812	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1091501007813	Cytochrome P450; Region: p450; cl12078
1091501007814	Acetoacetate decarboxylase (ADC); Region: ADC; cl01919
1091501007815	potential frameshift: common BLAST hit: gi|340628484|ref|YP_004746936.1| putative coenzyme F420-dependent oxidoreductase
1091501007816	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
1091501007817	DUF35 OB-fold domain; Region: DUF35; pfam01796
1091501007818	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
1091501007819	DUF35 OB-fold domain; Region: DUF35; pfam01796
1091501007820	potential frameshift: common BLAST hit: gi|339633521|ref|YP_004725163.1| lipid transfer protein or keto acyl-CoA thiolase LTP4
1091501007821	acetyl-CoA acetyltransferase; Provisional; Region: PRK08313
1091501007822	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
1091501007823	active site
1091501007824	NHL repeat; Region: NHL; pfam01436
1091501007825	Uncharacterized conserved protein [Function unknown]; Region: COG3391
1091501007826	NHL repeat; Region: NHL; pfam01436
1091501007827	NHL repeat; Region: NHL; pfam01436
1091501007828	NHL repeat; Region: NHL; pfam01436
1091501007829	NHL repeat; Region: NHL; pfam01436
1091501007830	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
1091501007831	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
1091501007832	trimer interface [polypeptide binding]; other site
1091501007833	putative metal binding site [ion binding]; other site
1091501007834	potential frameshift: common BLAST hit: gi|339633525|ref|YP_004725167.1| oxidoreductase
1091501007835	potential frameshift: common BLAST hit: gi|339633528|ref|YP_004725170.1| oxidoreductase
1091501007836	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1091501007837	PPE family; Region: PPE; pfam00823
1091501007838	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
1091501007839	potential frameshift: common BLAST hit: gi|339633531|ref|YP_004725173.1| PPE family protein
1091501007840	potential frameshift: common BLAST hit: gi|339633532|ref|YP_004725174.1| 4-hydroxy-2-oxovalerate aldolase
1091501007841	potential frameshift: common BLAST hit: gi|339633532|ref|YP_004725174.1| 4-hydroxy-2-oxovalerate aldolase
1091501007842	acetaldehyde dehydrogenase; Validated; Region: PRK08300
1091501007843	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1091501007844	Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290
1091501007845	2-keto-4-pentenoate hydratase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3971
1091501007846	potential frameshift: common BLAST hit: gi|253800578|ref|YP_003033579.1| 3-ketosteroid-delta-1-dehydrogenase
1091501007847	potential frameshift: common BLAST hit: gi|253800578|ref|YP_003033579.1| 3-ketosteroid-delta-1-dehydrogenase
1091501007848	potential frameshift: common BLAST hit: gi|340628502|ref|YP_004746954.1| putative dehydrogenase
1091501007849	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1091501007850	PPE family; Region: PPE; pfam00823
1091501007851	PE-PPE domain; Region: PE-PPE; pfam08237
1091501007852	lipid-transfer protein; Provisional; Region: PRK07855
1091501007853	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
1091501007854	active site
1091501007855	SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  The alpha- and...; Region: SAV4209; cd03455
1091501007856	putative active site [active]
1091501007857	putative catalytic site [active]
1091501007858	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
1091501007859	active site
1091501007860	catalytic site [active]
1091501007861	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
1091501007862	DUF35 OB-fold domain; Region: DUF35; pfam01796
1091501007863	potential frameshift: common BLAST hit: gi|340628507|ref|YP_004746959.1| putative acyl-CoA dehydrogenase FADE29
1091501007864	potential frameshift: common BLAST hit: gi|340628508|ref|YP_004746960.1| putative acyl-CoA dehydrogenase FADE28
1091501007865	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1091501007866	Cytochrome P450; Region: p450; cl12078
1091501007867	acetyl-CoA acetyltransferase; Provisional; Region: PRK07850
1091501007868	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1091501007869	dimer interface [polypeptide binding]; other site
1091501007870	active site
1091501007871	Domain of unknown function (DUF385); Region: DUF385; pfam04075
1091501007872	short chain dehydrogenase; Provisional; Region: PRK07791
1091501007873	(3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353
1091501007874	homodimer interface [polypeptide binding]; other site
1091501007875	NAD binding site [chemical binding]; other site
1091501007876	active site
1091501007877	short chain dehydrogenase; Provisional; Region: PRK07856
1091501007878	classical (c) SDRs; Region: SDR_c; cd05233
1091501007879	NAD(P) binding site [chemical binding]; other site
1091501007880	active site
1091501007881	enoyl-CoA hydratase; Provisional; Region: PRK06495
1091501007882	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1091501007883	substrate binding site [chemical binding]; other site
1091501007884	oxyanion hole (OAH) forming residues; other site
1091501007885	trimer interface [polypeptide binding]; other site
1091501007886	Coenzyme A transferase; Region: CoA_trans; cl17247
1091501007887	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
1091501007888	Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit [Lipid metabolism]; Region: AtoA; COG2057
1091501007889	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
1091501007890	FMN binding site [chemical binding]; other site
1091501007891	substrate binding site [chemical binding]; other site
1091501007892	putative catalytic residue [active]
1091501007893	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
1091501007894	Beta-carotene hydroxylase (CrtR), the carotenoid zeaxanthin biosynthetic enzyme catalyzes the addition of hydroxyl groups to the beta-ionone rings of beta-carotene to form zeaxanthin and is found in bacteria and red algae. Carotenoids are important...; Region: CrtR_beta-carotene-hydroxylase; cd03514
1091501007895	putative di-iron ligands [ion binding]; other site
1091501007896	phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160
1091501007897	NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214
1091501007898	FAD binding pocket [chemical binding]; other site
1091501007899	FAD binding motif [chemical binding]; other site
1091501007900	phosphate binding motif [ion binding]; other site
1091501007901	beta-alpha-beta structure motif; other site
1091501007902	NAD(p) ribose binding residues [chemical binding]; other site
1091501007903	NAD binding pocket [chemical binding]; other site
1091501007904	NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site
1091501007905	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1091501007906	catalytic loop [active]
1091501007907	iron binding site [ion binding]; other site
1091501007908	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
1091501007909	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
1091501007910	putative active site [active]
1091501007911	acetyl-CoA acetyltransferase; Provisional; Region: PRK07801
1091501007912	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1091501007913	dimer interface [polypeptide binding]; other site
1091501007914	active site
1091501007915	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1091501007916	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1091501007917	potential frameshift: common BLAST hit: gi|224991974|ref|YP_002646663.1| PPE family protein
1091501007918	short chain dehydrogenase; Provisional; Region: PRK07831
1091501007919	classical (c) SDRs; Region: SDR_c; cd05233
1091501007920	NAD(P) binding site [chemical binding]; other site
1091501007921	active site
1091501007922	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1091501007923	active site
1091501007924	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656
1091501007925	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1091501007926	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
1091501007927	acyl-activating enzyme (AAE) consensus motif; other site
1091501007928	putative AMP binding site [chemical binding]; other site
1091501007929	putative active site [active]
1091501007930	putative CoA binding site [chemical binding]; other site
1091501007931	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1091501007932	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1091501007933	active site
1091501007934	potential frameshift: common BLAST hit: gi|253800604|ref|YP_003033605.1| acyl-CoA dehydrogenase
1091501007935	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1091501007936	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
1091501007937	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1091501007938	active site
1091501007939	aspartate aminotransferase; Provisional; Region: PRK05764
1091501007940	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1091501007941	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1091501007942	homodimer interface [polypeptide binding]; other site
1091501007943	catalytic residue [active]
1091501007944	Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162
1091501007945	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
1091501007946	2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213
1091501007947	N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252
1091501007948	C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237
1091501007949	active site
1091501007950	Fe binding site [ion binding]; other site
1091501007951	2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343
1091501007952	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1091501007953	Naphthocyclinone hydroxylase; Region: NcnH; cd01159
1091501007954	Flavin binding site [chemical binding]; other site
1091501007955	potential frameshift: common BLAST hit: gi|339633570|ref|YP_004725212.1| hemoglobine-related protein HMP
1091501007956	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1091501007957	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1091501007958	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1091501007959	active site
1091501007960	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1091501007961	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1091501007962	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1091501007963	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cl17402
1091501007964	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279
1091501007965	putative dimerization interface [polypeptide binding]; other site
1091501007966	putative ligand binding site [chemical binding]; other site
1091501007967	PknH-like extracellular domain; Region: PknH_C; pfam14032
1091501007968	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
1091501007969	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
1091501007970	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
1091501007971	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
1091501007972	transmembrane helices; other site
1091501007973	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
1091501007974	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
1091501007975	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
1091501007976	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1091501007977	potential frameshift: common BLAST hit: gi|340628546|ref|YP_004746998.1| cysteinyl-tRNA synthetase 1 CYSS1
1091501007978	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
1091501007979	homotrimer interaction site [polypeptide binding]; other site
1091501007980	zinc binding site [ion binding]; other site
1091501007981	CDP-binding sites; other site
1091501007982	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
1091501007983	substrate binding site; other site
1091501007984	dimer interface; other site
1091501007985	Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329
1091501007986	potential frameshift: common BLAST hit: gi|340628551|ref|YP_004747003.1| DNA repair protein RADA
1091501007987	DNA integrity scanning protein DisA; Provisional; Region: PRK13482
1091501007988	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
1091501007989	DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635
1091501007990	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378
1091501007991	active site clefts [active]
1091501007992	zinc binding site [ion binding]; other site
1091501007993	dimer interface [polypeptide binding]; other site
1091501007994	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1091501007995	endonuclease III; Region: ENDO3c; smart00478
1091501007996	minor groove reading motif; other site
1091501007997	helix-hairpin-helix signature motif; other site
1091501007998	substrate binding pocket [chemical binding]; other site
1091501007999	active site
1091501008000	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
1091501008001	potential frameshift: common BLAST hit: gi|339633590|ref|YP_004725232.1| hydrolase
1091501008002	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
1091501008003	Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367
1091501008004	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
1091501008005	PE family; Region: PE; pfam00934
1091501008006	potential frameshift: common BLAST hit: gi|340628561|ref|YP_004747013.1| putative ATP-dependent protease ATP-binding subunit CLPC1
1091501008007	Lsr2; Region: Lsr2; pfam11774
1091501008008	potential frameshift: common BLAST hit: gi|339633597|ref|YP_004725239.1| lysyl-tRNA synthetase
1091501008009	pantothenate kinase; Reviewed; Region: PRK13318
1091501008010	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
1091501008011	tetramerization interface [polypeptide binding]; other site
1091501008012	active site
1091501008013	Pantoate-beta-alanine ligase; Region: PanC; cd00560
1091501008014	pantoate--beta-alanine ligase; Region: panC; TIGR00018
1091501008015	active site
1091501008016	ATP-binding site [chemical binding]; other site
1091501008017	pantoate-binding site; other site
1091501008018	HXXH motif; other site
1091501008019	Rossmann-like domain; Region: Rossmann-like; pfam10727
1091501008020	Uncharacterized conserved protein [Function unknown]; Region: COG5495
1091501008021	Domain of unknown function (DUF2520); Region: DUF2520; pfam10728
1091501008022	Protein of unknown function (DUF3180); Region: DUF3180; pfam11377
1091501008023	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
1091501008024	catalytic center binding site [active]
1091501008025	ATP binding site [chemical binding]; other site
1091501008026	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
1091501008027	homooctamer interface [polypeptide binding]; other site
1091501008028	active site
1091501008029	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
1091501008030	dihydropteroate synthase; Region: DHPS; TIGR01496
1091501008031	substrate binding pocket [chemical binding]; other site
1091501008032	dimer interface [polypeptide binding]; other site
1091501008033	inhibitor binding site; inhibition site
1091501008034	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
1091501008035	homodecamer interface [polypeptide binding]; other site
1091501008036	GTP cyclohydrolase I; Provisional; Region: PLN03044
1091501008037	active site
1091501008038	putative catalytic site residues [active]
1091501008039	zinc binding site [ion binding]; other site
1091501008040	GTP-CH-I/GFRP interaction surface; other site
1091501008041	FtsH Extracellular; Region: FtsH_ext; pfam06480
1091501008042	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
1091501008043	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1091501008044	Walker A motif; other site
1091501008045	ATP binding site [chemical binding]; other site
1091501008046	Walker B motif; other site
1091501008047	arginine finger; other site
1091501008048	Peptidase family M41; Region: Peptidase_M41; pfam01434
1091501008049	chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086
1091501008050	Protein of unknown function (DUF2580); Region: DUF2580; pfam10824
1091501008051	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1091501008052	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1091501008053	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1091501008054	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
1091501008055	Proteins of 100 residues with WXG; Region: WXG100; pfam06013
1091501008056	WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930
1091501008057	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1091501008058	PPE family; Region: PPE; pfam00823
1091501008059	PE family; Region: PE; pfam00934
1091501008060	Uncharacterized conserved protein [Function unknown]; Region: COG2968
1091501008061	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
1091501008062	potential frameshift: common BLAST hit: gi|340628589|ref|YP_004747041.1| hypoxanthine-guanine phosphoribosyltransferase HPT
1091501008063	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
1091501008064	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
1091501008065	Ligand Binding Site [chemical binding]; other site
1091501008066	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; pfam02113
1091501008067	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
1091501008068	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
1091501008069	dimer interface [polypeptide binding]; other site
1091501008070	substrate binding site [chemical binding]; other site
1091501008071	metal binding sites [ion binding]; metal-binding site
1091501008072	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2899
1091501008073	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
1091501008074	Ligand binding site; other site
1091501008075	Putative Catalytic site; other site
1091501008076	DXD motif; other site
1091501008077	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1091501008078	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1091501008079	NAD(P) binding site [chemical binding]; other site
1091501008080	active site
1091501008081	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
1091501008082	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
1091501008083	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
1091501008084	potential frameshift: common BLAST hit: gi|339633630|ref|YP_004725272.1| transposase
1091501008085	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1091501008086	MULE transposase domain; Region: MULE; pfam10551
1091501008087	Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184
1091501008088	Fic/DOC family; Region: Fic; cl00960
1091501008089	VbhA antitoxin and related proteins; Region: VbhA_like; cd11586
1091501008090	potential frameshift: common BLAST hit: gi|339633636|ref|YP_004725278.1| DNA POLYMERASE
1091501008091	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1091501008092	dimerization interface [polypeptide binding]; other site
1091501008093	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
1091501008094	cyclase homology domain; Region: CHD; cd07302
1091501008095	nucleotidyl binding site; other site
1091501008096	metal binding site [ion binding]; metal-binding site
1091501008097	dimer interface [polypeptide binding]; other site
1091501008098	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
1091501008099	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
1091501008100	active site
1091501008101	interdomain interaction site; other site
1091501008102	putative metal-binding site [ion binding]; other site
1091501008103	nucleotide binding site [chemical binding]; other site
1091501008104	Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436
1091501008105	domain I; other site
1091501008106	phosphate binding site [ion binding]; other site
1091501008107	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
1091501008108	domain II; other site
1091501008109	domain III; other site
1091501008110	nucleotide binding site [chemical binding]; other site
1091501008111	DNA binding groove [nucleotide binding]
1091501008112	catalytic site [active]
1091501008113	domain IV; other site
1091501008114	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
1091501008115	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
1091501008116	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
1091501008117	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1091501008118	DNA-binding site [nucleotide binding]; DNA binding site
1091501008119	RNA-binding motif; other site
1091501008120	helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817
1091501008121	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1091501008122	ATP binding site [chemical binding]; other site
1091501008123	putative Mg++ binding site [ion binding]; other site
1091501008124	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1091501008125	nucleotide binding region [chemical binding]; other site
1091501008126	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
1091501008127	PE family; Region: PE; pfam00934
1091501008128	PE family; Region: PE; pfam00934
1091501008129	Protein of unknown function (DUF4244); Region: DUF4244; pfam14029
1091501008130	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
1091501008131	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1091501008132	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
1091501008133	Walker A motif; other site
1091501008134	ATP binding site [chemical binding]; other site
1091501008135	Walker B motif; other site
1091501008136	helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815
1091501008137	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
1091501008138	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1091501008139	Walker A/P-loop; other site
1091501008140	ATP binding site [chemical binding]; other site
1091501008141	Q-loop/lid; other site
1091501008142	ABC transporter signature motif; other site
1091501008143	Walker B; other site
1091501008144	D-loop; other site
1091501008145	H-loop/switch region; other site
1091501008146	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1091501008147	Walker A/P-loop; other site
1091501008148	ATP binding site [chemical binding]; other site
1091501008149	Q-loop/lid; other site
1091501008150	ABC transporter signature motif; other site
1091501008151	Walker B; other site
1091501008152	D-loop; other site
1091501008153	H-loop/switch region; other site
1091501008154	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1091501008155	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
1091501008156	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1091501008157	ABC-ATPase subunit interface; other site
1091501008158	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1091501008159	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1091501008160	dimer interface [polypeptide binding]; other site
1091501008161	conserved gate region; other site
1091501008162	ABC-ATPase subunit interface; other site
1091501008163	potential frameshift: common BLAST hit: gi|224992076|ref|YP_002646765.1| periplasmic dipeptide-binding lipoprotein
1091501008164	potential frameshift: common BLAST hit: gi|339633658|ref|YP_004725300.1| acetyl-coenzyme A synthetase
1091501008165	Protein of unknown function (DUF1469); Region: DUF1469; pfam07332
1091501008166	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1091501008167	potential frameshift: common BLAST hit: gi|31794841|ref|NP_857334.1| membrane-associated serine protease
1091501008168	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
1091501008169	putative active site [active]
1091501008170	putative CoA binding site [chemical binding]; other site
1091501008171	nudix motif; other site
1091501008172	metal binding site [ion binding]; metal-binding site
1091501008173	potential frameshift: common BLAST hit: gi|339633664|ref|YP_004725306.1| thioredoxin
1091501008174	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
1091501008175	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1091501008176	minor groove reading motif; other site
1091501008177	helix-hairpin-helix signature motif; other site
1091501008178	substrate binding pocket [chemical binding]; other site
1091501008179	active site
1091501008180	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
1091501008181	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1091501008182	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1091501008183	ligand binding site [chemical binding]; other site
1091501008184	flexible hinge region; other site
1091501008185	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1091501008186	putative switch regulator; other site
1091501008187	non-specific DNA interactions [nucleotide binding]; other site
1091501008188	DNA binding site [nucleotide binding]
1091501008189	sequence specific DNA binding site [nucleotide binding]; other site
1091501008190	putative cAMP binding site [chemical binding]; other site
1091501008191	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1091501008192	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
1091501008193	homotrimer interaction site [polypeptide binding]; other site
1091501008194	putative active site [active]
1091501008195	Domain of unknown function (DUF4177); Region: DUF4177; pfam13783
1091501008196	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
1091501008197	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
1091501008198	P loop; other site
1091501008199	Nucleotide binding site [chemical binding]; other site
1091501008200	DTAP/Switch II; other site
1091501008201	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
1091501008202	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
1091501008203	DTAP/Switch II; other site
1091501008204	Switch I; other site
1091501008205	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
1091501008206	Transcription factor WhiB; Region: Whib; pfam02467
1091501008207	potential frameshift: common BLAST hit: gi|340628655|ref|YP_004747107.1| putative bifunctional membrane-associated penicillin-binding
1091501008208	Predicted phosphohydrolases [General function prediction only]; Region: COG1408
1091501008209	active site
1091501008210	metal binding site [ion binding]; metal-binding site
1091501008211	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1091501008212	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
1091501008213	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1091501008214	catalytic residue [active]
1091501008215	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1091501008216	Cytochrome P450; Region: p450; cl12078
1091501008217	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1091501008218	Cytochrome P450; Region: p450; cl12078
1091501008219	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
1091501008220	anti sigma factor interaction site; other site
1091501008221	regulatory phosphorylation site [posttranslational modification]; other site
1091501008222	Uncharacterized conserved protein [Function unknown]; Region: COG1610
1091501008223	potential frameshift: common BLAST hit: gi|224992099|ref|YP_002646788.1| transmembrane protein
1091501008224	Domain of unknown function (DUF4350); Region: DUF4350; pfam14258
1091501008225	MoxR-like ATPases [General function prediction only]; Region: COG0714
1091501008226	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1091501008227	Walker A motif; other site
1091501008228	ATP binding site [chemical binding]; other site
1091501008229	Walker B motif; other site
1091501008230	arginine finger; other site
1091501008231	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
1091501008232	Protein of unknown function DUF58; Region: DUF58; pfam01882
1091501008233	Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300
1091501008234	Predicted membrane protein/domain [Function unknown]; Region: COG1714
1091501008235	glycerol kinase; Provisional; Region: glpK; PRK00047
1091501008236	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1091501008237	nucleotide binding site [chemical binding]; other site
1091501008238	Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028
1091501008239	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1091501008240	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1091501008241	S-adenosylmethionine binding site [chemical binding]; other site
1091501008242	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1091501008243	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1091501008244	catalytic residue [active]
1091501008245	Uncharacterized conserved protein [Function unknown]; Region: COG4301
1091501008246	Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017
1091501008247	ergothioneine biosynthesis protein EgtC; Region: TIGR03442
1091501008248	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
1091501008249	putative active site [active]
1091501008250	putative dimer interface [polypeptide binding]; other site
1091501008251	ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440
1091501008252	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
1091501008253	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
1091501008254	PknH-like extracellular domain; Region: PknH_C; pfam14032
1091501008255	Domain of unknown function (DUF4185); Region: DUF4185; pfam13810
1091501008256	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
1091501008257	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1091501008258	aspartate kinase; Reviewed; Region: PRK06635
1091501008259	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
1091501008260	putative nucleotide binding site [chemical binding]; other site
1091501008261	putative catalytic residues [active]
1091501008262	putative Mg ion binding site [ion binding]; other site
1091501008263	putative aspartate binding site [chemical binding]; other site
1091501008264	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
1091501008265	putative allosteric regulatory site; other site
1091501008266	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
1091501008267	putative allosteric regulatory residue; other site
1091501008268	2-isopropylmalate synthase; Validated; Region: PRK03739
1091501008269	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
1091501008270	active site
1091501008271	catalytic residues [active]
1091501008272	metal binding site [ion binding]; metal-binding site
1091501008273	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
1091501008274	DNA polymerase III subunit epsilon; Provisional; Region: PRK06063
1091501008275	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
1091501008276	active site
1091501008277	catalytic site [active]
1091501008278	substrate binding site [chemical binding]; other site
1091501008279	UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769
1091501008280	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
1091501008281	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
1091501008282	catalytic triad [active]
1091501008283	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
1091501008284	putative active site [active]
1091501008285	recombination protein RecR; Reviewed; Region: recR; PRK00076
1091501008286	RecR protein; Region: RecR; pfam02132
1091501008287	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
1091501008288	putative active site [active]
1091501008289	putative metal-binding site [ion binding]; other site
1091501008290	tetramer interface [polypeptide binding]; other site
1091501008291	hypothetical protein; Validated; Region: PRK00153
1091501008292	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
1091501008293	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
1091501008294	active site
1091501008295	metal binding site [ion binding]; metal-binding site
1091501008296	Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604
1091501008297	hydrophobic ligand binding site; other site
1091501008298	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1091501008299	potential frameshift: common BLAST hit: gi|345462028|ref|NP_218237.2| fatty acid synthase
1091501008300	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14952
1091501008301	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1091501008302	Walker A motif; other site
1091501008303	ATP binding site [chemical binding]; other site
1091501008304	Walker B motif; other site
1091501008305	arginine finger; other site
1091501008306	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
1091501008307	Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897
1091501008308	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1091501008309	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1091501008310	catalytic residue [active]
1091501008311	Cutinase; Region: Cutinase; pfam01083
1091501008312	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1091501008313	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH8; cd08262
1091501008314	putative NAD(P) binding site [chemical binding]; other site
1091501008315	catalytic Zn binding site [ion binding]; other site
1091501008316	potential frameshift: common BLAST hit: gi|224992139|ref|YP_002646828.1| oxidoreductase
1091501008317	potential frameshift: common BLAST hit: gi|224992140|ref|YP_002646829.1| two-domain membrane protein
1091501008318	potential frameshift: common BLAST hit: gi|15843349|ref|NP_338386.1| drug transporter
1091501008319	potential frameshift: common BLAST hit: gi|253800776|ref|YP_003033777.1| transferase
1091501008320	LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865
1091501008321	nucleotide binding site [chemical binding]; other site
1091501008322	potential frameshift: common BLAST hit: gi|340628705|ref|YP_004747157.1| putative ATP-dependent DNA ligase
1091501008323	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4402
1091501008324	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_5; cd04662
1091501008325	nudix motif; other site
1091501008326	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
1091501008327	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
1091501008328	Uncharacterized conserved protein [Function unknown]; Region: COG1839
1091501008329	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
1091501008330	Helix-turn-helix domain; Region: HTH_18; pfam12833
1091501008331	Uncharacterized conserved protein [Function unknown]; Region: COG2966
1091501008332	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
1091501008333	Uncharacterized conserved protein [Function unknown]; Region: COG3610
1091501008334	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1091501008335	PPE family; Region: PPE; pfam00823
1091501008336	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
1091501008337	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
1091501008338	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
1091501008339	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
1091501008340	Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341
1091501008341	potential frameshift: common BLAST hit: gi|253800790|ref|YP_003033791.1| cation transporter P-type ATPase ctpJ
1091501008342	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1091501008343	dimerization interface [polypeptide binding]; other site
1091501008344	putative DNA binding site [nucleotide binding]; other site
1091501008345	putative Zn2+ binding site [ion binding]; other site
1091501008346	Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; cl01467
1091501008347	DNA binding domain, excisionase family; Region: excise; TIGR01764
1091501008348	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
1091501008349	nucleoside/Zn binding site; other site
1091501008350	dimer interface [polypeptide binding]; other site
1091501008351	catalytic motif [active]
1091501008352	putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941
1091501008353	prephenate dehydrogenase; Validated; Region: PRK06545
1091501008354	prephenate dehydrogenase; Validated; Region: PRK08507
1091501008355	Putative glycolipid-binding; Region: Glycolipid_bind; cl01425
1091501008356	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1091501008357	ABC-ATPase subunit interface; other site
1091501008358	ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174
1091501008359	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
1091501008360	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
1091501008361	Walker A/P-loop; other site
1091501008362	ATP binding site [chemical binding]; other site
1091501008363	Q-loop/lid; other site
1091501008364	ABC transporter signature motif; other site
1091501008365	Walker B; other site
1091501008366	D-loop; other site
1091501008367	H-loop/switch region; other site
1091501008368	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
1091501008369	Uncharacterized integral membrane protein [Function unknown]; Region: COG5416
1091501008370	potential frameshift: common BLAST hit: gi|339633755|ref|YP_004725397.1| acyl-CoA dehydrogenase
1091501008371	potential frameshift: common BLAST hit: gi|339633756|ref|YP_004725398.1| hydrolase
1091501008372	Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481
1091501008373	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1091501008374	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
1091501008375	dimerization interface [polypeptide binding]; other site
1091501008376	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1091501008377	dimer interface [polypeptide binding]; other site
1091501008378	phosphorylation site [posttranslational modification]
1091501008379	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1091501008380	ATP binding site [chemical binding]; other site
1091501008381	Mg2+ binding site [ion binding]; other site
1091501008382	G-X-G motif; other site
1091501008383	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1091501008384	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1091501008385	active site
1091501008386	phosphorylation site [posttranslational modification]
1091501008387	intermolecular recognition site; other site
1091501008388	dimerization interface [polypeptide binding]; other site
1091501008389	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1091501008390	DNA binding site [nucleotide binding]
1091501008391	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448
1091501008392	active site
1091501008393	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
1091501008394	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
1091501008395	SnoaL-like domain; Region: SnoaL_2; pfam12680
1091501008396	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
1091501008397	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1091501008398	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1091501008399	homodimer interface [polypeptide binding]; other site
1091501008400	catalytic residue [active]
1091501008401	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
1091501008402	TIGR03086 family protein; Region: TIGR03086
1091501008403	enoyl-CoA hydratase; Provisional; Region: PRK06142
1091501008404	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1091501008405	substrate binding site [chemical binding]; other site
1091501008406	oxyanion hole (OAH) forming residues; other site
1091501008407	trimer interface [polypeptide binding]; other site
1091501008408	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1091501008409	Beta-lactamase; Region: Beta-lactamase; pfam00144
1091501008410	potential protein location (hypothetical protein MRGA423_23790 [Mycobacterium tuberculosis RGTB423]) that overlaps RNA (tRNA-S)
1091501008411	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
1091501008412	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
1091501008413	NAD(P) binding site [chemical binding]; other site
1091501008414	potential frameshift: common BLAST hit: gi|339633774|ref|YP_004725416.1| aminotransferase
1091501008415	Protein of unknown function (DUF2587); Region: DUF2587; pfam10759
1091501008416	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
1091501008417	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
1091501008418	Walker A/P-loop; other site
1091501008419	ATP binding site [chemical binding]; other site
1091501008420	Q-loop/lid; other site
1091501008421	ABC transporter signature motif; other site
1091501008422	Walker B; other site
1091501008423	D-loop; other site
1091501008424	H-loop/switch region; other site
1091501008425	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
1091501008426	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1091501008427	active site
1091501008428	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
1091501008429	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
1091501008430	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1091501008431	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1091501008432	active site
1091501008433	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1091501008434	Peptidase family M23; Region: Peptidase_M23; pfam01551
1091501008435	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
1091501008436	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
1091501008437	nucleoside diphosphate kinase regulator; Provisional; Region: PRK05892
1091501008438	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
1091501008439	Predicted membrane protein [Function unknown]; Region: COG2246
1091501008440	GtrA-like protein; Region: GtrA; pfam04138
1091501008441	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1091501008442	FAD binding domain; Region: FAD_binding_4; pfam01565
1091501008443	D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030
1091501008444	short chain dehydrogenase; Provisional; Region: PRK07904
1091501008445	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
1091501008446	NAD(P) binding site [chemical binding]; other site
1091501008447	active site
1091501008448	potential frameshift: common BLAST hit: gi|224992204|ref|YP_002646894.1| transmembrane protein
1091501008449	potential frameshift: common BLAST hit: gi|339633789|ref|YP_004725431.1| indolylacetylinositol arabinosyltransferase
1091501008450	Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602
1091501008451	potential frameshift: common BLAST hit: gi|253800842|ref|YP_003033844.1| membrane indolylacetylinositol arabinosyltransferase embA
1091501008452	potential frameshift: common BLAST hit: gi|339633791|ref|YP_004725433.1| indolylacetylinositol arabinosyltransferase
1091501008453	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
1091501008454	Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154
1091501008455	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1091501008456	FAD binding site [chemical binding]; other site
1091501008457	substrate binding site [chemical binding]; other site
1091501008458	catalytic residues [active]
1091501008459	potential frameshift: common BLAST hit: gi|253800846|ref|YP_003033848.1| transposase
1091501008460	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
1091501008461	Transposase; Region: DDE_Tnp_ISL3; pfam01610
1091501008462	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
1091501008463	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
1091501008464	potential frameshift: common BLAST hit: gi|253800848|ref|YP_003033850.1| polyketide synthase
1091501008465	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
1091501008466	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1091501008467	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
1091501008468	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1091501008469	potential frameshift: common BLAST hit: gi|340628770|ref|YP_004747222.1| putative fatty-acid-CoA ligase FADD32
1091501008470	Cutinase; Region: Cutinase; pfam01083
1091501008471	potential frameshift: common BLAST hit: gi|253800851|ref|YP_003033853.1| secreted fibronectin-binding protein antigen protein fbpD
1091501008472	Putative esterase; Region: Esterase; pfam00756
1091501008473	phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324
1091501008474	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
1091501008475	active site
1091501008476	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
1091501008477	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1091501008478	active site
1091501008479	UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562
1091501008480	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1091501008481	UDP-galactopyranose mutase; Region: GLF; pfam03275
1091501008482	potential frameshift: common BLAST hit: gi|253800858|ref|YP_003033860.1| exported repetitive protein pirG
1091501008483	Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479
1091501008484	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
1091501008485	amidase catalytic site [active]
1091501008486	Zn binding residues [ion binding]; other site
1091501008487	substrate binding site [chemical binding]; other site
1091501008488	LGFP repeat; Region: LGFP; pfam08310
1091501008489	PE family; Region: PE; pfam00934
1091501008490	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1091501008491	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1091501008492	active site
1091501008493	motif I; other site
1091501008494	motif II; other site
1091501008495	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1091501008496	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1091501008497	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1091501008498	putative acyl-acceptor binding pocket; other site
1091501008499	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1091501008500	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1091501008501	putative acyl-acceptor binding pocket; other site
1091501008502	potential frameshift: common BLAST hit: gi|339633811|ref|YP_004725453.1| acyltransferase
1091501008503	Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150
1091501008504	Phosphotransferase enzyme family; Region: APH; pfam01636
1091501008505	active site
1091501008506	ATP binding site [chemical binding]; other site
1091501008507	antibiotic binding site [chemical binding]; other site
1091501008508	Protein of unknown function (DUF2910); Region: DUF2910; pfam11139
1091501008509	PE-PPE domain; Region: PE-PPE; pfam08237
1091501008510	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
1091501008511	Condensation domain; Region: Condensation; pfam00668
1091501008512	potential frameshift: common BLAST hit: gi|339633820|ref|YP_004725462.1| polyketide synthase
1091501008513	potential frameshift: common BLAST hit: gi|339633820|ref|YP_004725462.1| polyketide synthase
1091501008514	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1091501008515	AMP binding site [chemical binding]; other site
1091501008516	active site
1091501008517	CoA binding site [chemical binding]; other site
1091501008518	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
1091501008519	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
1091501008520	Probable transposase; Region: OrfB_IS605; pfam01385
1091501008521	potential frameshift: common BLAST hit: gi|339633823|ref|YP_004725465.1| resolvase
1091501008522	potential frameshift: common BLAST hit: gi|340628798|ref|YP_004747250.1| putative dehydrogenase
1091501008523	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
1091501008524	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1091501008525	Protein of unknown function (DUF2834); Region: DUF2834; pfam11196
1091501008526	Methyltransferase domain; Region: Methyltransf_11; pfam08241
1091501008527	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1091501008528	potential frameshift: common BLAST hit: gi|339633828|ref|YP_004725470.1| AraC family transcriptional regulator
1091501008529	seryl-tRNA synthetase; Provisional; Region: PRK05431
1091501008530	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
1091501008531	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
1091501008532	dimer interface [polypeptide binding]; other site
1091501008533	active site
1091501008534	motif 1; other site
1091501008535	motif 2; other site
1091501008536	motif 3; other site
1091501008537	Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952
1091501008538	Broad specificity phosphatase PhoE and related phosphatases [General function prediction only]; Region: phoE; COG0406
1091501008539	prephenate dehydratase; Provisional; Region: PRK11898
1091501008540	Prephenate dehydratase; Region: PDT; pfam00800
1091501008541	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
1091501008542	putative L-Phe binding site [chemical binding]; other site
1091501008543	Transcriptional regulator [Transcription]; Region: LytR; COG1316
1091501008544	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
1091501008545	Ferritin-like domain; Region: Ferritin; pfam00210
1091501008546	ferroxidase diiron center [ion binding]; other site
1091501008547	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582
1091501008548	Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009
1091501008549	putative active site [active]
1091501008550	catalytic site [active]
1091501008551	putative metal binding site [ion binding]; other site
1091501008552	Domain of unknown function (DUF4328); Region: DUF4328; pfam14219
1091501008553	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1091501008554	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
1091501008555	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
1091501008556	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
1091501008557	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
1091501008558	Predicted membrane protein [Function unknown]; Region: COG2119
1091501008559	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
1091501008560	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
1091501008561	Fimbrial protein; Region: Fimbrial; cl01416
1091501008562	ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372
1091501008563	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
1091501008564	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
1091501008565	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1091501008566	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1091501008567	hypothetical protein; Provisional; Region: PRK07945
1091501008568	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
1091501008569	Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436
1091501008570	active site
1091501008571	potential frameshift: common BLAST hit: gi|340628830|ref|YP_004747282.1| putative NADH-dependent glutamate synthase small subunit GLTD
1091501008572	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
1091501008573	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
1091501008574	active site
1091501008575	dimer interface [polypeptide binding]; other site
1091501008576	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
1091501008577	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
1091501008578	active site
1091501008579	FMN binding site [chemical binding]; other site
1091501008580	substrate binding site [chemical binding]; other site
1091501008581	3Fe-4S cluster binding site [ion binding]; other site
1091501008582	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
1091501008583	domain interface; other site
1091501008584	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
1091501008585	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
1091501008586	Protein of unknown function (DUF2580); Region: DUF2580; pfam10824
1091501008587	EspG family; Region: ESX-1_EspG; pfam14011
1091501008588	Protein of unknown function (DUF690); Region: DUF690; pfam05108
1091501008589	type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924
1091501008590	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1091501008591	PE family; Region: PE; pfam00934
1091501008592	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1091501008593	PPE family; Region: PPE; pfam00823
1091501008594	Proteins of 100 residues with WXG; Region: WXG100; cl02005
1091501008595	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842
1091501008596	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
1091501008597	potential frameshift: common BLAST hit: gi|148663744|ref|YP_001285267.1| transmembrane protein
1091501008598	YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575
1091501008599	type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923
1091501008600	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
1091501008601	type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921
1091501008602	active site
1091501008603	catalytic residues [active]
1091501008604	type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922
1091501008605	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1091501008606	Walker A motif; other site
1091501008607	ATP binding site [chemical binding]; other site
1091501008608	Walker B motif; other site
1091501008609	arginine finger; other site
1091501008610	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
1091501008611	active site
1091501008612	catalytic residues [active]
1091501008613	type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920
1091501008614	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
1091501008615	EspG family; Region: ESX-1_EspG; pfam14011
1091501008616	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842
1091501008617	Proteins of 100 residues with WXG; Region: WXG100; pfam06013
1091501008618	potential frameshift: common BLAST hit: gi|253800942|ref|YP_003033944.1| PPE family protein
1091501008619	Protein of unknown function (DUF690); Region: DUF690; pfam05108
1091501008620	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1091501008621	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1091501008622	catalytic residue [active]
1091501008623	Protein of unknown function (DUF4237); Region: DUF4237; pfam14021
1091501008624	Proteins of 100 residues with WXG; Region: WXG100; cl02005
1091501008625	tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692
1091501008626	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
1091501008627	active site
1091501008628	NTP binding site [chemical binding]; other site
1091501008629	metal binding triad [ion binding]; metal-binding site
1091501008630	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
1091501008631	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1091501008632	Zn2+ binding site [ion binding]; other site
1091501008633	Mg2+ binding site [ion binding]; other site
1091501008634	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
1091501008635	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
1091501008636	active site
1091501008637	Ap6A binding site [chemical binding]; other site
1091501008638	nudix motif; other site
1091501008639	metal binding site [ion binding]; metal-binding site
1091501008640	potential frameshift: common BLAST hit: gi|148825118|ref|YP_001289872.1| transmembrane protein
1091501008641	potential frameshift: common BLAST hit: gi|148825118|ref|YP_001289872.1| transmembrane protein
1091501008642	RNA polymerase sigma factor SigM; Reviewed; Region: PRK09643
1091501008643	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1091501008644	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1091501008645	DNA binding residues [nucleotide binding]
1091501008646	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
1091501008647	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1091501008648	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1091501008649	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1091501008650	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1091501008651	catalytic residues [active]
1091501008652	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
1091501008653	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1091501008654	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1091501008655	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
1091501008656	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
1091501008657	active site
1091501008658	metal binding site [ion binding]; metal-binding site
1091501008659	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
1091501008660	ParB-like nuclease domain; Region: ParB; smart00470
1091501008661	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1091501008662	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1091501008663	P-loop; other site
1091501008664	Magnesium ion binding site [ion binding]; other site
1091501008665	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1091501008666	Magnesium ion binding site [ion binding]; other site
1091501008667	rRNA small subunit methyltransferase G; Region: GidB; pfam02527
1091501008668	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
1091501008669	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
1091501008670	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
1091501008671	G-X-X-G motif; other site
1091501008672	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
1091501008673	RxxxH motif; other site
1091501008674	potential frameshift: common BLAST hit: gi|148825129|ref|YP_001289883.1| putative inner membrane protein translocase component YidC
1091501008675	Uncharacterized conserved protein [Function unknown]; Region: COG0759
1091501008676	ribonuclease P; Reviewed; Region: rnpA; PRK00588
1091501008677	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399