-- dump date 20140619_155316 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1097669000001 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 1097669000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1097669000003 Walker A motif; other site 1097669000004 ATP binding site [chemical binding]; other site 1097669000005 Walker B motif; other site 1097669000006 arginine finger; other site 1097669000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1097669000008 DnaA box-binding interface [nucleotide binding]; other site 1097669000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 1097669000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1097669000011 putative DNA binding surface [nucleotide binding]; other site 1097669000012 dimer interface [polypeptide binding]; other site 1097669000013 beta-clamp/clamp loader binding surface; other site 1097669000014 beta-clamp/translesion DNA polymerase binding surface; other site 1097669000015 recF protein; Region: recf; TIGR00611 1097669000016 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 1097669000017 Walker A/P-loop; other site 1097669000018 ATP binding site [chemical binding]; other site 1097669000019 Q-loop/lid; other site 1097669000020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1097669000021 ABC transporter signature motif; other site 1097669000022 Walker B; other site 1097669000023 D-loop; other site 1097669000024 H-loop/switch region; other site 1097669000025 hypothetical protein; Provisional; Region: PRK03195 1097669000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1097669000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1097669000028 Mg2+ binding site [ion binding]; other site 1097669000029 G-X-G motif; other site 1097669000030 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1097669000031 anchoring element; other site 1097669000032 dimer interface [polypeptide binding]; other site 1097669000033 ATP binding site [chemical binding]; other site 1097669000034 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1097669000035 active site 1097669000036 putative metal-binding site [ion binding]; other site 1097669000037 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1097669000038 DNA gyrase subunit A; Validated; Region: PRK05560 1097669000039 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1097669000040 CAP-like domain; other site 1097669000041 active site 1097669000042 primary dimer interface [polypeptide binding]; other site 1097669000043 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1097669000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1097669000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1097669000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1097669000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1097669000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1097669000049 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 1097669000050 Protein of unknown function (DUF2562); Region: DUF2562; pfam10814 1097669000051 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1097669000052 active site 1097669000053 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1097669000054 putative septation inhibitor protein; Reviewed; Region: PRK00159 1097669000055 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 1097669000056 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1097669000057 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1097669000058 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1097669000059 glutamine binding [chemical binding]; other site 1097669000060 catalytic triad [active] 1097669000061 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1097669000062 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1097669000063 active site 1097669000064 ATP binding site [chemical binding]; other site 1097669000065 substrate binding site [chemical binding]; other site 1097669000066 activation loop (A-loop); other site 1097669000067 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 1097669000068 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1097669000069 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1097669000070 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1097669000071 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1097669000072 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1097669000073 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1097669000074 active site 1097669000075 ATP binding site [chemical binding]; other site 1097669000076 substrate binding site [chemical binding]; other site 1097669000077 activation loop (A-loop); other site 1097669000078 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1097669000079 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1097669000080 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1097669000081 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1097669000082 active site 1097669000083 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1097669000084 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1097669000085 phosphopeptide binding site; other site 1097669000086 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 1097669000087 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1097669000088 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1097669000089 phosphopeptide binding site; other site 1097669000090 Nitronate monooxygenase; Region: NMO; pfam03060 1097669000091 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1097669000092 FMN binding site [chemical binding]; other site 1097669000093 substrate binding site [chemical binding]; other site 1097669000094 putative catalytic residue [active] 1097669000095 Transcription factor WhiB; Region: Whib; pfam02467 1097669000096 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1097669000097 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1097669000098 non-specific DNA binding site [nucleotide binding]; other site 1097669000099 salt bridge; other site 1097669000100 sequence-specific DNA binding site [nucleotide binding]; other site 1097669000101 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1097669000102 NlpC/P60 family; Region: NLPC_P60; pfam00877 1097669000103 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 1097669000104 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 1097669000105 Protein of unknown function (DUF2694); Region: DUF2694; pfam10904 1097669000106 Protein of unknown function (DUF2710); Region: DUF2710; pfam10921 1097669000107 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1097669000108 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 1097669000109 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1097669000110 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1097669000111 catalytic residue [active] 1097669000112 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 1097669000113 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 1097669000114 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1097669000115 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1097669000116 acyl-activating enzyme (AAE) consensus motif; other site 1097669000117 active site 1097669000118 TIGR03084 family protein; Region: TIGR03084 1097669000119 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1097669000120 Wyosine base formation; Region: Wyosine_form; pfam08608 1097669000121 H+ Antiporter protein; Region: 2A0121; TIGR00900 1097669000122 hypothetical protein; Validated; Region: PRK00228 1097669000123 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 1097669000124 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1097669000125 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1097669000126 active site 1097669000127 HIGH motif; other site 1097669000128 nucleotide binding site [chemical binding]; other site 1097669000129 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1097669000130 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1097669000131 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1097669000132 active site 1097669000133 KMSKS motif; other site 1097669000134 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1097669000135 tRNA binding surface [nucleotide binding]; other site 1097669000136 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1097669000137 MarR family; Region: MarR; pfam01047 1097669000138 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1097669000139 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1097669000140 DNA-binding site [nucleotide binding]; DNA binding site 1097669000141 probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856 1097669000142 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1097669000143 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1097669000144 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 1097669000145 inositol 1-phosphate synthase, Actinobacterial type; Region: mycothiol_INO1; TIGR03450 1097669000146 Predicted transcriptional regulators [Transcription]; Region: COG1695 1097669000147 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1097669000148 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1097669000149 Transglycosylase; Region: Transgly; pfam00912 1097669000150 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1097669000151 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1097669000152 Predicted integral membrane protein [Function unknown]; Region: COG5650 1097669000153 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 1097669000154 conserved cys residue [active] 1097669000155 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1097669000156 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1097669000157 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1097669000158 dimer interface [polypeptide binding]; other site 1097669000159 ssDNA binding site [nucleotide binding]; other site 1097669000160 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1097669000161 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1097669000162 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1097669000163 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1097669000164 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1097669000165 replicative DNA helicase; Validated; Region: PRK07773 1097669000166 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1097669000167 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1097669000168 Walker A motif; other site 1097669000169 ATP binding site [chemical binding]; other site 1097669000170 Walker B motif; other site 1097669000171 DNA binding loops [nucleotide binding] 1097669000172 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1097669000173 protein-splicing catalytic site; other site 1097669000174 thioester formation/cholesterol transfer; other site 1097669000175 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1097669000176 protein-splicing catalytic site; other site 1097669000177 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1097669000178 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 1097669000179 ADP-ribose binding site [chemical binding]; other site 1097669000180 Predicted phosphatase homologous to the C-terminal domain of histone macroH2A1 [General function prediction only]; Region: COG2110 1097669000181 Cellobiohydrolase A (1,4-beta-cellobiosidase A) [Carbohydrate transport and metabolism]; Region: CelA; COG5297 1097669000182 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 1097669000183 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1097669000184 FAD binding domain; Region: FAD_binding_4; pfam01565 1097669000185 Berberine and berberine like; Region: BBE; pfam08031 1097669000186 hypothetical protein; Provisional; Region: PRK12438 1097669000187 hypothetical protein; Validated; Region: PRK00068 1097669000188 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 1097669000189 homotetrameric interface [polypeptide binding]; other site 1097669000190 putative active site [active] 1097669000191 metal binding site [ion binding]; metal-binding site 1097669000192 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 1097669000193 Monomeric isocitrate dehydrogenase; Region: IDH; pfam03971 1097669000194 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1097669000195 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1097669000196 short chain dehydrogenase; Provisional; Region: PRK06197 1097669000197 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 1097669000198 putative NAD(P) binding site [chemical binding]; other site 1097669000199 active site 1097669000200 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1097669000201 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1097669000202 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1097669000203 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1097669000204 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1097669000205 dimer interface [polypeptide binding]; other site 1097669000206 active site 1097669000207 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1097669000208 folate binding site [chemical binding]; other site 1097669000209 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 1097669000210 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1097669000211 putative NTP binding site [chemical binding]; other site 1097669000212 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1097669000213 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1097669000214 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1097669000215 Walker A/P-loop; other site 1097669000216 ATP binding site [chemical binding]; other site 1097669000217 Q-loop/lid; other site 1097669000218 ABC transporter signature motif; other site 1097669000219 Walker B; other site 1097669000220 D-loop; other site 1097669000221 H-loop/switch region; other site 1097669000222 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1097669000223 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1097669000224 ligand binding site [chemical binding]; other site 1097669000225 flexible hinge region; other site 1097669000226 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 1097669000227 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1097669000228 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 1097669000229 active site 1097669000230 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1097669000231 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1097669000232 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1097669000233 homodimer interface [polypeptide binding]; other site 1097669000234 catalytic residue [active] 1097669000235 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1097669000236 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1097669000237 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1097669000238 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 1097669000239 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1097669000240 dimerization interface [polypeptide binding]; other site 1097669000241 putative DNA binding site [nucleotide binding]; other site 1097669000242 putative Zn2+ binding site [ion binding]; other site 1097669000243 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 1097669000244 hydrogenase 4 subunit B; Validated; Region: PRK06521 1097669000245 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1097669000246 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1097669000247 NADH dehydrogenase; Region: NADHdh; cl00469 1097669000248 Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; COG4237 1097669000249 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1097669000250 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 1097669000251 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 1097669000252 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 1097669000253 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 1097669000254 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825 1097669000255 putative hydrophobic ligand binding site [chemical binding]; other site 1097669000256 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1097669000257 S-adenosylmethionine binding site [chemical binding]; other site 1097669000258 Predicted membrane protein [Function unknown]; Region: COG3305 1097669000259 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1097669000260 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1097669000261 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1097669000262 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1097669000263 metal-binding site [ion binding] 1097669000264 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1097669000265 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1097669000266 Predicted integral membrane protein [Function unknown]; Region: COG5660 1097669000267 Putative zinc-finger; Region: zf-HC2; pfam13490 1097669000268 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1097669000269 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1097669000270 PPE family; Region: PPE; pfam00823 1097669000271 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1097669000272 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 1097669000273 FcoT-like thioesterase domain; Region: FcoT; pfam10862 1097669000274 acyl-CoA synthetase; Validated; Region: PRK05857 1097669000275 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1097669000276 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 1097669000277 acyl-activating enzyme (AAE) consensus motif; other site 1097669000278 acyl-activating enzyme (AAE) consensus motif; other site 1097669000279 AMP binding site [chemical binding]; other site 1097669000280 active site 1097669000281 CoA binding site [chemical binding]; other site 1097669000282 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1097669000283 AMP-binding enzyme; Region: AMP-binding; pfam00501 1097669000284 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1097669000285 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1097669000286 acyl-activating enzyme (AAE) consensus motif; other site 1097669000287 acyl-activating enzyme (AAE) consensus motif; other site 1097669000288 active site 1097669000289 AMP binding site [chemical binding]; other site 1097669000290 CoA binding site [chemical binding]; other site 1097669000291 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1097669000292 Condensation domain; Region: Condensation; pfam00668 1097669000293 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1097669000294 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1097669000295 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1097669000296 acyl-activating enzyme (AAE) consensus motif; other site 1097669000297 AMP binding site [chemical binding]; other site 1097669000298 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1097669000299 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 1097669000300 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 1097669000301 putative NAD(P) binding site [chemical binding]; other site 1097669000302 active site 1097669000303 putative substrate binding site [chemical binding]; other site 1097669000304 Predicted membrane protein [Function unknown]; Region: COG3336 1097669000305 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1097669000306 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1097669000307 metal-binding site [ion binding] 1097669000308 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1097669000309 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1097669000310 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1097669000311 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1097669000312 ligand binding site [chemical binding]; other site 1097669000313 flexible hinge region; other site 1097669000314 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1097669000315 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1097669000316 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1097669000317 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1097669000318 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1097669000319 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1097669000320 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1097669000321 motif II; other site 1097669000322 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1097669000323 PE family; Region: PE; pfam00934 1097669000324 Rhomboid family; Region: Rhomboid; pfam01694 1097669000325 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1097669000326 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1097669000327 active site 1097669000328 catalytic triad [active] 1097669000329 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1097669000330 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 1097669000331 NADP-binding site; other site 1097669000332 homotetramer interface [polypeptide binding]; other site 1097669000333 substrate binding site [chemical binding]; other site 1097669000334 homodimer interface [polypeptide binding]; other site 1097669000335 active site 1097669000336 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1097669000337 dimer interface [polypeptide binding]; other site 1097669000338 active site 1097669000339 histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656 1097669000340 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1097669000341 active site 1097669000342 motif I; other site 1097669000343 motif II; other site 1097669000344 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 1097669000345 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1097669000346 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 1097669000347 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1097669000348 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1097669000349 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1097669000350 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1097669000351 dimerization interface [polypeptide binding]; other site 1097669000352 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 1097669000353 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1097669000354 PYR/PP interface [polypeptide binding]; other site 1097669000355 dimer interface [polypeptide binding]; other site 1097669000356 TPP binding site [chemical binding]; other site 1097669000357 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1097669000358 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 1097669000359 TPP-binding site; other site 1097669000360 dimer interface [polypeptide binding]; other site 1097669000361 acyl-CoA synthetase; Validated; Region: PRK05852 1097669000362 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1097669000363 Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; Region: FACL_fum10p_like; cd05926 1097669000364 acyl-activating enzyme (AAE) consensus motif; other site 1097669000365 acyl-activating enzyme (AAE) consensus motif; other site 1097669000366 putative AMP binding site [chemical binding]; other site 1097669000367 putative active site [active] 1097669000368 putative CoA binding site [chemical binding]; other site 1097669000369 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 1097669000370 elongation factor G; Reviewed; Region: PRK12740 1097669000371 G1 box; other site 1097669000372 putative GEF interaction site [polypeptide binding]; other site 1097669000373 GTP/Mg2+ binding site [chemical binding]; other site 1097669000374 Switch I region; other site 1097669000375 G2 box; other site 1097669000376 G3 box; other site 1097669000377 Switch II region; other site 1097669000378 G4 box; other site 1097669000379 G5 box; other site 1097669000380 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1097669000381 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1097669000382 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1097669000383 PPOX class probable F420-dependent enzyme, Rv0121 family; Region: Rv0121_F420; TIGR03668 1097669000384 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1097669000385 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1097669000386 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1097669000387 trehalose synthase; Region: treS_nterm; TIGR02456 1097669000388 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 1097669000389 active site 1097669000390 catalytic site [active] 1097669000391 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 1097669000392 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 1097669000393 Predicted membrane protein [Function unknown]; Region: COG3619 1097669000394 Predicted esterase [General function prediction only]; Region: COG0627 1097669000395 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 1097669000396 putative active site [active] 1097669000397 putative catalytic site [active] 1097669000398 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1097669000399 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1097669000400 active site 1097669000401 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 1097669000402 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1097669000403 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1097669000404 Coenzyme A binding pocket [chemical binding]; other site 1097669000405 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1097669000406 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1097669000407 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1097669000408 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1097669000409 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1097669000410 SnoaL-like domain; Region: SnoaL_2; pfam12680 1097669000411 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 1097669000412 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1097669000413 NAD(P) binding site [chemical binding]; other site 1097669000414 active site 1097669000415 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 1097669000416 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 1097669000417 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 1097669000418 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1097669000419 minor groove reading motif; other site 1097669000420 helix-hairpin-helix signature motif; other site 1097669000421 active site 1097669000422 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1097669000423 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 1097669000424 Cl- selectivity filter; other site 1097669000425 Cl- binding residues [ion binding]; other site 1097669000426 pore gating glutamate residue; other site 1097669000427 dimer interface [polypeptide binding]; other site 1097669000428 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1097669000429 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1097669000430 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1097669000431 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1097669000432 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1097669000433 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1097669000434 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 1097669000435 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 1097669000436 NAD(P) binding site [chemical binding]; other site 1097669000437 catalytic residues [active] 1097669000438 short chain dehydrogenase; Provisional; Region: PRK07791 1097669000439 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 1097669000440 NAD binding site [chemical binding]; other site 1097669000441 homodimer interface [polypeptide binding]; other site 1097669000442 active site 1097669000443 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1097669000444 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 1097669000445 NAD(P) binding site [chemical binding]; other site 1097669000446 PE family; Region: PE; pfam00934 1097669000447 PE-PPE domain; Region: PE-PPE; pfam08237 1097669000448 PE-PPE domain; Region: PE-PPE; pfam08237 1097669000449 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 1097669000450 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 1097669000451 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 1097669000452 Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155 1097669000453 FAD binding site [chemical binding]; other site 1097669000454 substrate binding site [chemical binding]; other site 1097669000455 catalytic base [active] 1097669000456 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 1097669000457 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 1097669000458 ligand binding site [chemical binding]; other site 1097669000459 homodimer interface [polypeptide binding]; other site 1097669000460 NAD(P) binding site [chemical binding]; other site 1097669000461 trimer interface B [polypeptide binding]; other site 1097669000462 trimer interface A [polypeptide binding]; other site 1097669000463 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 1097669000464 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 1097669000465 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 1097669000466 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 1097669000467 pseudo 1097669000468 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1097669000469 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1097669000470 QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360 1097669000471 PE family; Region: PE; pfam00934 1097669000472 PE-PPE domain; Region: PE-PPE; pfam08237 1097669000473 PE family; Region: PE; pfam00934 1097669000474 PE-PPE domain; Region: PE-PPE; pfam08237 1097669000475 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1097669000476 FAD binding domain; Region: FAD_binding_4; pfam01565 1097669000477 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 1097669000478 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1097669000479 NAD(P) binding site [chemical binding]; other site 1097669000480 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1097669000481 active site 1097669000482 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1097669000483 putative hydrophobic ligand binding site [chemical binding]; other site 1097669000484 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1097669000485 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1097669000486 DNA-binding site [nucleotide binding]; DNA binding site 1097669000487 FCD domain; Region: FCD; pfam07729 1097669000488 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07786 1097669000489 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1097669000490 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1097669000491 acyl-activating enzyme (AAE) consensus motif; other site 1097669000492 acyl-activating enzyme (AAE) consensus motif; other site 1097669000493 putative AMP binding site [chemical binding]; other site 1097669000494 putative active site [active] 1097669000495 putative CoA binding site [chemical binding]; other site 1097669000496 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1097669000497 Permease; Region: Permease; pfam02405 1097669000498 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1097669000499 Permease; Region: Permease; pfam02405 1097669000500 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1097669000501 mce related protein; Region: MCE; pfam02470 1097669000502 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1097669000503 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1097669000504 mce related protein; Region: MCE; pfam02470 1097669000505 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1097669000506 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1097669000507 mce related protein; Region: MCE; pfam02470 1097669000508 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1097669000509 mce related protein; Region: MCE; pfam02470 1097669000510 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1097669000511 mce related protein; Region: MCE; pfam02470 1097669000512 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1097669000513 mce related protein; Region: MCE; pfam02470 1097669000514 RDD family; Region: RDD; pfam06271 1097669000515 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 1097669000516 Predicted membrane protein [Function unknown]; Region: COG1511 1097669000517 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1097669000518 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1097669000519 Pirin-related protein [General function prediction only]; Region: COG1741 1097669000520 Pirin; Region: Pirin; pfam02678 1097669000521 RNA polymerase factor sigma-70; Validated; Region: PRK08241 1097669000522 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1097669000523 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1097669000524 DNA binding residues [nucleotide binding] 1097669000525 SnoaL-like domain; Region: SnoaL_2; pfam12680 1097669000526 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1097669000527 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1097669000528 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 1097669000529 putative metallohydrolase, TIGR04338 family; Region: HEXXH_Rv0185 1097669000530 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1097669000531 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1097669000532 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1097669000533 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1097669000534 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1097669000535 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1097669000536 S-adenosylmethionine binding site [chemical binding]; other site 1097669000537 SPW repeat; Region: SPW; pfam03779 1097669000538 SPW repeat; Region: SPW; pfam03779 1097669000539 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 1097669000540 6-phosphogluconate dehydratase; Region: edd; TIGR01196 1097669000541 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 1097669000542 putative homodimer interface [polypeptide binding]; other site 1097669000543 putative homotetramer interface [polypeptide binding]; other site 1097669000544 putative allosteric switch controlling residues; other site 1097669000545 putative metal binding site [ion binding]; other site 1097669000546 putative homodimer-homodimer interface [polypeptide binding]; other site 1097669000547 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1097669000548 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1097669000549 putative substrate translocation pore; other site 1097669000550 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1097669000551 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 1097669000552 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1097669000553 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1097669000554 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1097669000555 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1097669000556 Walker A/P-loop; other site 1097669000557 ATP binding site [chemical binding]; other site 1097669000558 Q-loop/lid; other site 1097669000559 ABC transporter signature motif; other site 1097669000560 Walker B; other site 1097669000561 D-loop; other site 1097669000562 H-loop/switch region; other site 1097669000563 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1097669000564 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1097669000565 Walker A/P-loop; other site 1097669000566 ATP binding site [chemical binding]; other site 1097669000567 Q-loop/lid; other site 1097669000568 ABC transporter signature motif; other site 1097669000569 Walker B; other site 1097669000570 D-loop; other site 1097669000571 H-loop/switch region; other site 1097669000572 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1097669000573 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1097669000574 dimerization interface [polypeptide binding]; other site 1097669000575 DNA binding residues [nucleotide binding] 1097669000576 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1097669000577 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1097669000578 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1097669000579 The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762 1097669000580 putative [Fe4-S4] binding site [ion binding]; other site 1097669000581 putative molybdopterin cofactor binding site [chemical binding]; other site 1097669000582 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1097669000583 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 1097669000584 putative molybdopterin cofactor binding site; other site 1097669000585 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 1097669000586 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 1097669000587 active site 1097669000588 Zn binding site [ion binding]; other site 1097669000589 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1097669000590 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 1097669000591 Predicted integral membrane protein [Function unknown]; Region: COG0392 1097669000592 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1097669000593 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1097669000594 MMPL family; Region: MMPL; pfam03176 1097669000595 MMPL family; Region: MMPL; pfam03176 1097669000596 LabA_like proteins; Region: LabA_like; cd06167 1097669000597 putative metal binding site [ion binding]; other site 1097669000598 Putative methyltransferase; Region: Methyltransf_4; pfam02390 1097669000599 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 1097669000600 active site 1097669000601 substrate-binding site [chemical binding]; other site 1097669000602 metal-binding site [ion binding] 1097669000603 GTP binding site [chemical binding]; other site 1097669000604 nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526 1097669000605 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 1097669000606 active site 1097669000607 (T/H)XGH motif; other site 1097669000608 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 1097669000609 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 1097669000610 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 1097669000611 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1097669000612 FeS/SAM binding site; other site 1097669000613 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 1097669000614 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1097669000615 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1097669000616 acyl-activating enzyme (AAE) consensus motif; other site 1097669000617 acyl-activating enzyme (AAE) consensus motif; other site 1097669000618 putative AMP binding site [chemical binding]; other site 1097669000619 putative active site [active] 1097669000620 putative CoA binding site [chemical binding]; other site 1097669000621 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1097669000622 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1097669000623 active site 1097669000624 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 1097669000625 putative active site [active] 1097669000626 putative catalytic site [active] 1097669000627 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1097669000628 active site 2 [active] 1097669000629 active site 1 [active] 1097669000630 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1097669000631 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1097669000632 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1097669000633 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cd00321 1097669000634 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1097669000635 Moco binding site; other site 1097669000636 metal coordination site [ion binding]; other site 1097669000637 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1097669000638 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1097669000639 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1097669000640 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1097669000641 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 1097669000642 enoyl-CoA hydratase; Provisional; Region: PRK08252 1097669000643 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1097669000644 substrate binding site [chemical binding]; other site 1097669000645 oxyanion hole (OAH) forming residues; other site 1097669000646 trimer interface [polypeptide binding]; other site 1097669000647 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 1097669000648 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1097669000649 NAD binding site [chemical binding]; other site 1097669000650 catalytic residues [active] 1097669000651 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1097669000652 S-adenosylmethionine binding site [chemical binding]; other site 1097669000653 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1097669000654 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1097669000655 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 1097669000656 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1097669000657 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 1097669000658 putative active site [active] 1097669000659 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 1097669000660 active site 1097669000661 substrate binding pocket [chemical binding]; other site 1097669000662 homodimer interaction site [polypeptide binding]; other site 1097669000663 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1097669000664 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1097669000665 active site 1097669000666 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1097669000667 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1097669000668 Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain; Region: RNRR2_Rv0233_like; cd07911 1097669000669 active site 1097669000670 diiron metal binding site [ion binding]; other site 1097669000671 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1097669000672 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1097669000673 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1097669000674 NAD(P) binding site [chemical binding]; other site 1097669000675 catalytic residues [active] 1097669000676 Lipase maturation factor; Region: LMF1; pfam06762 1097669000677 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 1097669000678 Protein of unknown function (DUF2613); Region: DUF2613; pfam11021 1097669000679 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1097669000680 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1097669000681 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1097669000682 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1097669000683 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 1097669000684 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1097669000685 MaoC like domain; Region: MaoC_dehydratas; pfam01575 1097669000686 active site 2 [active] 1097669000687 active site 1 [active] 1097669000688 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 1097669000689 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1097669000690 NAD(P) binding site [chemical binding]; other site 1097669000691 active site 1097669000692 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 1097669000693 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1097669000694 dimer interface [polypeptide binding]; other site 1097669000695 active site 1097669000696 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1097669000697 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1097669000698 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 1097669000699 FAD binding site [chemical binding]; other site 1097669000700 substrate binding site [chemical binding]; other site 1097669000701 catalytic residues [active] 1097669000702 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1097669000703 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1097669000704 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386 1097669000705 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1097669000706 catalytic loop [active] 1097669000707 iron binding site [ion binding]; other site 1097669000708 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803 1097669000709 L-aspartate oxidase; Provisional; Region: PRK06175 1097669000710 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1097669000711 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1097669000712 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1097669000713 putative dimer interface [polypeptide binding]; other site 1097669000714 nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374 1097669000715 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1097669000716 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1097669000717 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1097669000718 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 1097669000719 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 1097669000720 homotrimer interface [polypeptide binding]; other site 1097669000721 Walker A motif; other site 1097669000722 GTP binding site [chemical binding]; other site 1097669000723 Walker B motif; other site 1097669000724 cobyric acid synthase; Provisional; Region: PRK00784 1097669000725 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 1097669000726 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1097669000727 catalytic triad [active] 1097669000728 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1097669000729 PPE family; Region: PPE; pfam00823 1097669000730 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1097669000731 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1097669000732 putative active site [active] 1097669000733 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 1097669000734 putative active site [active] 1097669000735 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 1097669000736 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1097669000737 active site 1097669000738 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 1097669000739 DNA binding site [nucleotide binding] 1097669000740 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1097669000741 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1097669000742 Coenzyme A binding pocket [chemical binding]; other site 1097669000743 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 1097669000744 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 1097669000745 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 1097669000746 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1097669000747 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1097669000748 intersubunit interface [polypeptide binding]; other site 1097669000749 5-oxoprolinase; Region: PLN02666 1097669000750 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 1097669000751 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 1097669000752 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 1097669000753 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1097669000754 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 1097669000755 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 1097669000756 nucleotide binding site [chemical binding]; other site 1097669000757 acyl-CoA synthetase; Validated; Region: PRK07788 1097669000758 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1097669000759 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1097669000760 active site 1097669000761 CoA binding site [chemical binding]; other site 1097669000762 AMP binding site [chemical binding]; other site 1097669000763 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1097669000764 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1097669000765 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 1097669000766 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1097669000767 FAD binding site [chemical binding]; other site 1097669000768 substrate binding site [chemical binding]; other site 1097669000769 catalytic base [active] 1097669000770 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1097669000771 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1097669000772 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1097669000773 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1097669000774 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1097669000775 Zn binding site [ion binding]; other site 1097669000776 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 1097669000777 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 1097669000778 putative active site [active] 1097669000779 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1097669000780 PPE family; Region: PPE; pfam00823 1097669000781 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1097669000782 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1097669000783 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1097669000784 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 1097669000785 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1097669000786 Walker A motif; other site 1097669000787 ATP binding site [chemical binding]; other site 1097669000788 Walker B motif; other site 1097669000789 arginine finger; other site 1097669000790 Protein of unknown function (DUF690); Region: DUF690; pfam05108 1097669000791 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1097669000792 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1097669000793 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1097669000794 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1097669000795 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1097669000796 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1097669000797 PPE family; Region: PPE; pfam00823 1097669000798 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1097669000799 EspG family; Region: ESX-1_EspG; pfam14011 1097669000800 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 1097669000801 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1097669000802 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 1097669000803 active site 1097669000804 catalytic residues [active] 1097669000805 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 1097669000806 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1097669000807 Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752 1097669000808 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 1097669000809 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1097669000810 S-adenosylmethionine binding site [chemical binding]; other site 1097669000811 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4424 1097669000812 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1097669000813 Sulfatase; Region: Sulfatase; cl17466 1097669000814 hypothetical protein; Region: PHA01748 1097669000815 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 1097669000816 putative active site [active] 1097669000817 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1097669000818 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1097669000819 light-dependent protochlorophyllide reductase (LPOR)-like, classical (c)-like SDRs; Region: LPOR_like_SDR_c_like; cd09810 1097669000820 protochlorophyllide reductase; Region: PLN00015 1097669000821 putative NAD(P) binding site [chemical binding]; other site 1097669000822 active site 1097669000823 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1097669000824 PPE family; Region: PPE; pfam00823 1097669000825 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1097669000826 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1097669000827 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1097669000828 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1097669000829 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1097669000830 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1097669000831 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1097669000832 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1097669000833 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1097669000834 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1097669000835 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1097669000836 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1097669000837 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 1097669000838 putative FMN binding site [chemical binding]; other site 1097669000839 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1097669000840 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1097669000841 active site 1097669000842 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 1097669000843 SnoaL-like domain; Region: SnoaL_4; pfam13577 1097669000844 SnoaL-like domain; Region: SnoaL_3; pfam13474 1097669000845 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 1097669000846 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1097669000847 nucleotide binding site [chemical binding]; other site 1097669000848 Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones]; Region: HtpG; COG0326 1097669000849 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 1097669000850 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 1097669000851 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 1097669000852 active site 1097669000853 catalytic residues [active] 1097669000854 Muconolactone delta-isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CatC1; COG4829 1097669000855 Muconolactone delta-isomerase; Region: MIase; cl01992 1097669000856 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 1097669000857 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 1097669000858 putative active site [active] 1097669000859 catalytic site [active] 1097669000860 putative metal binding site [ion binding]; other site 1097669000861 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 1097669000862 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 1097669000863 putative substrate binding pocket [chemical binding]; other site 1097669000864 AC domain interface; other site 1097669000865 catalytic triad [active] 1097669000866 AB domain interface; other site 1097669000867 interchain disulfide; other site 1097669000868 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1097669000869 trimer interface [polypeptide binding]; other site 1097669000870 active site 1097669000871 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1097669000872 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1097669000873 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1097669000874 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1097669000875 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 1097669000876 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1097669000877 dimerization interface [polypeptide binding]; other site 1097669000878 putative DNA binding site [nucleotide binding]; other site 1097669000879 putative Zn2+ binding site [ion binding]; other site 1097669000880 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1097669000881 active site residue [active] 1097669000882 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1097669000883 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1097669000884 Cytochrome P450; Region: p450; cl12078 1097669000885 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 1097669000886 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1097669000887 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1097669000888 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1097669000889 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1097669000890 S-adenosylmethionine binding site [chemical binding]; other site 1097669000891 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1097669000892 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1097669000893 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1097669000894 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1097669000895 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1097669000896 SnoaL-like domain; Region: SnoaL_2; pfam12680 1097669000897 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1097669000898 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1097669000899 substrate binding site; other site 1097669000900 tetramer interface; other site 1097669000901 PE family; Region: PE; pfam00934 1097669000902 aminotransferase AlaT; Validated; Region: PRK09265 1097669000903 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1097669000904 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1097669000905 homodimer interface [polypeptide binding]; other site 1097669000906 catalytic residue [active] 1097669000907 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1097669000908 4Fe-4S binding domain; Region: Fer4; pfam00037 1097669000909 Cysteine-rich domain; Region: CCG; pfam02754 1097669000910 Cysteine-rich domain; Region: CCG; pfam02754 1097669000911 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1097669000912 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1097669000913 DNA binding residues [nucleotide binding] 1097669000914 dimerization interface [polypeptide binding]; other site 1097669000915 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 1097669000916 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1097669000917 G1 box; other site 1097669000918 GTP/Mg2+ binding site [chemical binding]; other site 1097669000919 G2 box; other site 1097669000920 Switch I region; other site 1097669000921 G3 box; other site 1097669000922 Switch II region; other site 1097669000923 G4 box; other site 1097669000924 G5 box; other site 1097669000925 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 1097669000926 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1097669000927 G1 box; other site 1097669000928 GTP/Mg2+ binding site [chemical binding]; other site 1097669000929 G2 box; other site 1097669000930 Switch I region; other site 1097669000931 G3 box; other site 1097669000932 Switch II region; other site 1097669000933 Uncharacterized MobA-related protein [General function prediction only]; Region: COG2068 1097669000934 active site 1097669000935 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1097669000936 TIGR04255 family protein; Region: sporadTIGR04255 1097669000937 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1097669000938 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1097669000939 nucleotide binding site [chemical binding]; other site 1097669000940 NEF interaction site [polypeptide binding]; other site 1097669000941 SBD interface [polypeptide binding]; other site 1097669000942 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 1097669000943 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1097669000944 dimer interface [polypeptide binding]; other site 1097669000945 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1097669000946 chaperone protein DnaJ; Provisional; Region: PRK14279 1097669000947 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1097669000948 HSP70 interaction site [polypeptide binding]; other site 1097669000949 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1097669000950 Zn binding sites [ion binding]; other site 1097669000951 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1097669000952 dimer interface [polypeptide binding]; other site 1097669000953 Helix-Turn-Helix DNA binding domain of HspR-like transcription regulators; Region: HTH_HspR-like; cd01279 1097669000954 DNA binding residues [nucleotide binding] 1097669000955 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1097669000956 putative dimer interface [polypeptide binding]; other site 1097669000957 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1097669000958 PPE family; Region: PPE; pfam00823 1097669000959 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1097669000960 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1097669000961 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1097669000962 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1097669000963 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1097669000964 CoenzymeA binding site [chemical binding]; other site 1097669000965 subunit interaction site [polypeptide binding]; other site 1097669000966 PHB binding site; other site 1097669000967 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1097669000968 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1097669000969 GDP-binding site [chemical binding]; other site 1097669000970 ACT binding site; other site 1097669000971 IMP binding site; other site 1097669000972 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 1097669000973 Peptidase family M50; Region: Peptidase_M50; pfam02163 1097669000974 active site 1097669000975 putative substrate binding region [chemical binding]; other site 1097669000976 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 1097669000977 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1097669000978 MgtE intracellular N domain; Region: MgtE_N; pfam03448 1097669000979 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1097669000980 Divalent cation transporter; Region: MgtE; pfam01769 1097669000981 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1097669000982 fructose-bisphosphate aldolase, class II, yeast/E. coli subtype; Region: FruBisAldo_II_A; TIGR01520 1097669000983 active site 1097669000984 intersubunit interface [polypeptide binding]; other site 1097669000985 zinc binding site [ion binding]; other site 1097669000986 Na+ binding site [ion binding]; other site 1097669000987 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1097669000988 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1097669000989 Predicted glycosyl hydrolase [Carbohydrate transport and metabolism]; Region: COG4833 1097669000990 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 1097669000991 AAA domain; Region: AAA_33; pfam13671 1097669000992 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 1097669000993 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 1097669000994 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 1097669000995 putative hydrophobic ligand binding site [chemical binding]; other site 1097669000996 MoxR-like ATPases [General function prediction only]; Region: COG0714 1097669000997 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 1097669000998 Ligand binding site; other site 1097669000999 metal-binding site 1097669001000 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 1097669001001 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1097669001002 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1097669001003 carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416 1097669001004 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 1097669001005 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1097669001006 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1097669001007 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1097669001008 catalytic loop [active] 1097669001009 iron binding site [ion binding]; other site 1097669001010 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1097669001011 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 1097669001012 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 1097669001013 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1097669001014 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 1097669001015 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1097669001016 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1097669001017 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1097669001018 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1097669001019 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1097669001020 dimerization interface [polypeptide binding]; other site 1097669001021 Uncharacterized conserved protein [Function unknown]; Region: COG3360 1097669001022 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1097669001023 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1097669001024 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1097669001025 active site 1097669001026 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1097669001027 Clp amino terminal domain; Region: Clp_N; pfam02861 1097669001028 Clp amino terminal domain; Region: Clp_N; pfam02861 1097669001029 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1097669001030 Walker A motif; other site 1097669001031 ATP binding site [chemical binding]; other site 1097669001032 Walker B motif; other site 1097669001033 arginine finger; other site 1097669001034 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1097669001035 Walker A motif; other site 1097669001036 ATP binding site [chemical binding]; other site 1097669001037 Walker B motif; other site 1097669001038 arginine finger; other site 1097669001039 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1097669001040 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1097669001041 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1097669001042 heme-binding site [chemical binding]; other site 1097669001043 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 1097669001044 FAD binding pocket [chemical binding]; other site 1097669001045 FAD binding motif [chemical binding]; other site 1097669001046 phosphate binding motif [ion binding]; other site 1097669001047 beta-alpha-beta structure motif; other site 1097669001048 NAD binding pocket [chemical binding]; other site 1097669001049 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1097669001050 cyclase homology domain; Region: CHD; cd07302 1097669001051 nucleotidyl binding site; other site 1097669001052 metal binding site [ion binding]; metal-binding site 1097669001053 dimer interface [polypeptide binding]; other site 1097669001054 Predicted ATPase [General function prediction only]; Region: COG3903 1097669001055 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1097669001056 Walker A motif; other site 1097669001057 ATP binding site [chemical binding]; other site 1097669001058 Walker B motif; other site 1097669001059 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1097669001060 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1097669001061 DNA binding residues [nucleotide binding] 1097669001062 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1097669001063 PPE family; Region: PPE; pfam00823 1097669001064 Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase) [Nucleotide transport and metabolism]; Region: PurT; COG0027 1097669001065 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1097669001066 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 1097669001067 active site residue [active] 1097669001068 O-succinylhomoserine sulfhydrylase; Provisional; Region: PRK07810 1097669001069 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1097669001070 homodimer interface [polypeptide binding]; other site 1097669001071 substrate-cofactor binding pocket; other site 1097669001072 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1097669001073 catalytic residue [active] 1097669001074 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1097669001075 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1097669001076 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1097669001077 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1097669001078 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1097669001079 active site 1097669001080 PLD-like domain; Region: PLDc_2; pfam13091 1097669001081 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1097669001082 Beta-lactamase; Region: Beta-lactamase; pfam00144 1097669001083 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 1097669001084 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1097669001085 FAD binding site [chemical binding]; other site 1097669001086 substrate binding pocket [chemical binding]; other site 1097669001087 catalytic base [active] 1097669001088 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 1097669001089 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1097669001090 acyl-CoA synthetase; Validated; Region: PRK05850 1097669001091 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1097669001092 acyl-activating enzyme (AAE) consensus motif; other site 1097669001093 active site 1097669001094 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 1097669001095 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1097669001096 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1097669001097 active site 1097669001098 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1097669001099 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1097669001100 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1097669001101 Thioesterase; Region: PKS_TE; smart00824 1097669001102 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1097669001103 glucose-6-phosphate dehydrogenase (coenzyme-F420); Region: F420_G6P_DH; TIGR03554 1097669001104 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 1097669001105 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1097669001106 phosphate acetyltransferase; Reviewed; Region: PRK05632 1097669001107 DRTGG domain; Region: DRTGG; pfam07085 1097669001108 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1097669001109 propionate/acetate kinase; Provisional; Region: PRK12379 1097669001110 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1097669001111 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1097669001112 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1097669001113 active site 1097669001114 ATP binding site [chemical binding]; other site 1097669001115 substrate binding site [chemical binding]; other site 1097669001116 activation loop (A-loop); other site 1097669001117 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1097669001118 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1097669001119 substrate binding pocket [chemical binding]; other site 1097669001120 membrane-bound complex binding site; other site 1097669001121 hinge residues; other site 1097669001122 NUDIX domain; Region: NUDIX; pfam00293 1097669001123 nudix motif; other site 1097669001124 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1097669001125 thiamine phosphate binding site [chemical binding]; other site 1097669001126 active site 1097669001127 pyrophosphate binding site [ion binding]; other site 1097669001128 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1097669001129 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1097669001130 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1097669001131 thiS-thiF/thiG interaction site; other site 1097669001132 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1097669001133 ThiS interaction site; other site 1097669001134 putative active site [active] 1097669001135 tetramer interface [polypeptide binding]; other site 1097669001136 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 1097669001137 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1097669001138 PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH. Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816 1097669001139 PA/protease or protease-like domain interface [polypeptide binding]; other site 1097669001140 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 1097669001141 active site 1097669001142 metal binding site [ion binding]; metal-binding site 1097669001143 Predicted metalloprotease [General function prediction only]; Region: COG2321 1097669001144 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1097669001145 Zn binding site [ion binding]; other site 1097669001146 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1097669001147 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1097669001148 dimer interface [polypeptide binding]; other site 1097669001149 substrate binding site [chemical binding]; other site 1097669001150 ATP binding site [chemical binding]; other site 1097669001151 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1097669001152 ThiC-associated domain; Region: ThiC-associated; pfam13667 1097669001153 ThiC family; Region: ThiC; pfam01964 1097669001154 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1097669001155 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 1097669001156 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1097669001157 motif II; other site 1097669001158 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1097669001159 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1097669001160 putative catalytic site [active] 1097669001161 putative phosphate binding site [ion binding]; other site 1097669001162 active site 1097669001163 metal binding site A [ion binding]; metal-binding site 1097669001164 DNA binding site [nucleotide binding] 1097669001165 putative AP binding site [nucleotide binding]; other site 1097669001166 putative metal binding site B [ion binding]; other site 1097669001167 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1097669001168 active site 1097669001169 catalytic residues [active] 1097669001170 metal binding site [ion binding]; metal-binding site 1097669001171 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 1097669001172 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1097669001173 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 1097669001174 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1097669001175 E-class dimer interface [polypeptide binding]; other site 1097669001176 P-class dimer interface [polypeptide binding]; other site 1097669001177 active site 1097669001178 Cu2+ binding site [ion binding]; other site 1097669001179 Zn2+ binding site [ion binding]; other site 1097669001180 carboxylate-amine ligase; Provisional; Region: PRK13517 1097669001181 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 1097669001182 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 1097669001183 AAA family ATPase, CDC48 subfamily; Region: CDC48; TIGR01243 1097669001184 Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359 1097669001185 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1097669001186 Walker A motif; other site 1097669001187 ATP binding site [chemical binding]; other site 1097669001188 Walker B motif; other site 1097669001189 arginine finger; other site 1097669001190 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1097669001191 Walker A motif; other site 1097669001192 ATP binding site [chemical binding]; other site 1097669001193 Walker B motif; other site 1097669001194 arginine finger; other site 1097669001195 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 1097669001196 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1097669001197 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 1097669001198 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1097669001199 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1097669001200 dimer interface [polypeptide binding]; other site 1097669001201 putative functional site; other site 1097669001202 putative MPT binding site; other site 1097669001203 short chain dehydrogenase; Provisional; Region: PRK06197 1097669001204 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 1097669001205 putative NAD(P) binding site [chemical binding]; other site 1097669001206 active site 1097669001207 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1097669001208 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1097669001209 ring oligomerisation interface [polypeptide binding]; other site 1097669001210 ATP/Mg binding site [chemical binding]; other site 1097669001211 stacking interactions; other site 1097669001212 hinge regions; other site 1097669001213 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1097669001214 PPE family; Region: PPE; pfam00823 1097669001215 Protein of unknown function (DUF664); Region: DUF664; pfam04978 1097669001216 DinB superfamily; Region: DinB_2; pfam12867 1097669001217 putative anti-sigmaE protein; Provisional; Region: PRK13920 1097669001218 Anti-sigma-K factor rskA; Region: RskA; pfam10099 1097669001219 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 1097669001220 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1097669001221 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1097669001222 DNA binding residues [nucleotide binding] 1097669001223 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 1097669001224 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1097669001225 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1097669001226 S-adenosylmethionine binding site [chemical binding]; other site 1097669001227 Uncharacterized conserved protein [Function unknown]; Region: COG3496 1097669001228 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 1097669001229 Subunit A of Class III extradiol dioxygenases; Region: Extradiol_Dioxygenase_3A_like; cl06673 1097669001230 dimer interface [polypeptide binding]; other site 1097669001231 Transport protein; Region: actII; TIGR00833 1097669001232 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1097669001233 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1097669001234 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1097669001235 PPE family; Region: PPE; pfam00823 1097669001236 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1097669001237 Protein of unknown function (DUF2782); Region: DUF2782; pfam11191 1097669001238 enoyl-CoA hydratase; Provisional; Region: PRK12478 1097669001239 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1097669001240 substrate binding site [chemical binding]; other site 1097669001241 oxyanion hole (OAH) forming residues; other site 1097669001242 trimer interface [polypeptide binding]; other site 1097669001243 PemK-like protein; Region: PemK; pfam02452 1097669001244 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 1097669001245 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1097669001246 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 1097669001247 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1097669001248 NAD(P) binding site [chemical binding]; other site 1097669001249 catalytic residues [active] 1097669001250 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3564 1097669001251 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 1097669001252 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1097669001253 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1097669001254 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1097669001255 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1097669001256 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1097669001257 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1097669001258 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1097669001259 non-specific DNA binding site [nucleotide binding]; other site 1097669001260 salt bridge; other site 1097669001261 sequence-specific DNA binding site [nucleotide binding]; other site 1097669001262 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 1097669001263 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1097669001264 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 1097669001265 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 1097669001266 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1097669001267 active site 1097669001268 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1097669001269 active site 2 [active] 1097669001270 isocitrate lyase; Provisional; Region: PRK15063 1097669001271 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cd06556 1097669001272 oligomerization interface [polypeptide binding]; other site 1097669001273 active site 1097669001274 metal binding site [ion binding]; metal-binding site 1097669001275 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 1097669001276 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1097669001277 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1097669001278 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1097669001279 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1097669001280 S-adenosylmethionine binding site [chemical binding]; other site 1097669001281 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1097669001282 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1097669001283 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1097669001284 S-adenosylmethionine binding site [chemical binding]; other site 1097669001285 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224 1097669001286 UbiA prenyltransferase family; Region: UbiA; pfam01040 1097669001287 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1097669001288 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1097669001289 Predicted membrane protein [Function unknown]; Region: COG2733 1097669001290 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1097669001291 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1097669001292 non-specific DNA binding site [nucleotide binding]; other site 1097669001293 salt bridge; other site 1097669001294 sequence-specific DNA binding site [nucleotide binding]; other site 1097669001295 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 1097669001296 Protein of unknown function (DUF2599); Region: DUF2599; pfam10783 1097669001297 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1097669001298 intersubunit interface [polypeptide binding]; other site 1097669001299 active site 1097669001300 catalytic residue [active] 1097669001301 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1097669001302 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1097669001303 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 1097669001304 putative active site [active] 1097669001305 catalytic triad [active] 1097669001306 putative dimer interface [polypeptide binding]; other site 1097669001307 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 1097669001308 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 1097669001309 FAD binding domain; Region: FAD_binding_4; pfam01565 1097669001310 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1097669001311 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 1097669001312 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1097669001313 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 1097669001314 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1097669001315 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1097669001316 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1097669001317 NAD(P) binding site [chemical binding]; other site 1097669001318 active site 1097669001319 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1097669001320 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1097669001321 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 1097669001322 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 1097669001323 putative ADP-binding pocket [chemical binding]; other site 1097669001324 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1097669001325 L-lysine exporter; Region: 2a75; TIGR00948 1097669001326 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1097669001327 catalytic core [active] 1097669001328 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 1097669001329 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1097669001330 dimer interface [polypeptide binding]; other site 1097669001331 phosphorylation site [posttranslational modification] 1097669001332 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1097669001333 ATP binding site [chemical binding]; other site 1097669001334 Mg2+ binding site [ion binding]; other site 1097669001335 G-X-G motif; other site 1097669001336 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1097669001337 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1097669001338 active site 1097669001339 phosphorylation site [posttranslational modification] 1097669001340 intermolecular recognition site; other site 1097669001341 dimerization interface [polypeptide binding]; other site 1097669001342 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1097669001343 DNA binding site [nucleotide binding] 1097669001344 GMC oxidoreductase; Region: GMC_oxred_N; pfam00732 1097669001345 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1097669001346 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1097669001347 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1097669001348 DNA-binding site [nucleotide binding]; DNA binding site 1097669001349 FCD domain; Region: FCD; pfam07729 1097669001350 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1097669001351 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1097669001352 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1097669001353 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1097669001354 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1097669001355 Diacylglycerol kinase catalytic domain (presumed); Region: DAGKc; smart00046 1097669001356 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1097669001357 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 1097669001358 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1097669001359 DNA binding domain, excisionase family; Region: excise; TIGR01764 1097669001360 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1097669001361 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 1097669001362 putative NAD(P) binding site [chemical binding]; other site 1097669001363 active site 1097669001364 putative substrate binding site [chemical binding]; other site 1097669001365 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1097669001366 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 1097669001367 putative acyl-acceptor binding pocket; other site 1097669001368 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1097669001369 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1097669001370 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1097669001371 S-adenosylmethionine binding site [chemical binding]; other site 1097669001372 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1097669001373 active site 1097669001374 catalytic site [active] 1097669001375 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1097669001376 HAD-superfamily subfamily IB hydrolase, TIGR01490; Region: HAD-SF-IB-hyp1 1097669001377 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1097669001378 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1097669001379 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 1097669001380 glutamyl-tRNA reductase; Region: hemA; TIGR01035 1097669001381 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1097669001382 tRNA; other site 1097669001383 putative tRNA binding site [nucleotide binding]; other site 1097669001384 putative NADP binding site [chemical binding]; other site 1097669001385 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1097669001386 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1097669001387 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1097669001388 domain interfaces; other site 1097669001389 active site 1097669001390 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 1097669001391 active site 1097669001392 homodimer interface [polypeptide binding]; other site 1097669001393 SAM binding site [chemical binding]; other site 1097669001394 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1097669001395 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1097669001396 active site 1097669001397 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1097669001398 dimer interface [polypeptide binding]; other site 1097669001399 active site 1097669001400 Schiff base residues; other site 1097669001401 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1097669001402 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1097669001403 active site 1097669001404 catalytic triad [active] 1097669001405 oxyanion hole [active] 1097669001406 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 1097669001407 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1097669001408 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1097669001409 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1097669001410 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1097669001411 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1097669001412 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1097669001413 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1097669001414 catalytic residue [active] 1097669001415 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1097669001416 catalytic core [active] 1097669001417 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1097669001418 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1097669001419 catalytic residues [active] 1097669001420 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1097669001421 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1097669001422 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 1097669001423 ResB-like family; Region: ResB; pfam05140 1097669001424 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 1097669001425 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1097669001426 AAA domain; Region: AAA_31; pfam13614 1097669001427 P-loop; other site 1097669001428 Magnesium ion binding site [ion binding]; other site 1097669001429 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1097669001430 Protein of unknown function (DUF4229); Region: DUF4229; pfam14012 1097669001431 3-oxoacyl-(acyl-carrier-protein) synthase III; Region: fabH; TIGR00747 1097669001432 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1097669001433 dimer interface [polypeptide binding]; other site 1097669001434 active site 1097669001435 CoA binding pocket [chemical binding]; other site 1097669001436 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Region: menA; TIGR00751 1097669001437 UbiA prenyltransferase family; Region: UbiA; pfam01040 1097669001438 5'-methylthioadenosine phosphorylase; Validated; Region: PRK07823 1097669001439 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1097669001440 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1097669001441 NAD(P) binding site [chemical binding]; other site 1097669001442 active site 1097669001443 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1097669001444 Ligand binding site; other site 1097669001445 Putative Catalytic site; other site 1097669001446 DXD motif; other site 1097669001447 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3222 1097669001448 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 1097669001449 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1097669001450 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1097669001451 acyl-activating enzyme (AAE) consensus motif; other site 1097669001452 acyl-activating enzyme (AAE) consensus motif; other site 1097669001453 AMP binding site [chemical binding]; other site 1097669001454 active site 1097669001455 CoA binding site [chemical binding]; other site 1097669001456 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 1097669001457 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1097669001458 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1097669001459 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1097669001460 active site 1097669001461 short chain dehydrogenase; Provisional; Region: PRK05866 1097669001462 classical (c) SDRs; Region: SDR_c; cd05233 1097669001463 NAD(P) binding site [chemical binding]; other site 1097669001464 active site 1097669001465 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1097669001466 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1097669001467 substrate binding site [chemical binding]; other site 1097669001468 oxyanion hole (OAH) forming residues; other site 1097669001469 trimer interface [polypeptide binding]; other site 1097669001470 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 1097669001471 putative active site [active] 1097669001472 homotetrameric interface [polypeptide binding]; other site 1097669001473 metal binding site [ion binding]; metal-binding site 1097669001474 Post-segregation antitoxin (ccd killing mechanism protein) encoded by the F plasmid [General function prediction only]; Region: COG5302 1097669001475 acyl-CoA synthetase; Validated; Region: PRK06188 1097669001476 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1097669001477 putative active site [active] 1097669001478 putative CoA binding site [chemical binding]; other site 1097669001479 putative AMP binding site [chemical binding]; other site 1097669001480 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1097669001481 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1097669001482 active site 1097669001483 O-succinylbenzoate synthase; Provisional; Region: PRK02901 1097669001484 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 1097669001485 active site 1097669001486 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1097669001487 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1097669001488 TAP-like protein; Region: Abhydrolase_4; pfam08386 1097669001489 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 1097669001490 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1097669001491 dimer interface [polypeptide binding]; other site 1097669001492 tetramer interface [polypeptide binding]; other site 1097669001493 PYR/PP interface [polypeptide binding]; other site 1097669001494 TPP binding site [chemical binding]; other site 1097669001495 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1097669001496 TPP-binding site; other site 1097669001497 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 1097669001498 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1097669001499 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1097669001500 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1097669001501 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1097669001502 S-adenosylmethionine binding site [chemical binding]; other site 1097669001503 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1097669001504 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1097669001505 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1097669001506 S-adenosylmethionine binding site [chemical binding]; other site 1097669001507 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 1097669001508 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1097669001509 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1097669001510 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1097669001511 substrate binding pocket [chemical binding]; other site 1097669001512 chain length determination region; other site 1097669001513 substrate-Mg2+ binding site; other site 1097669001514 catalytic residues [active] 1097669001515 aspartate-rich region 1; other site 1097669001516 active site lid residues [active] 1097669001517 aspartate-rich region 2; other site 1097669001518 heat shock protein HtpX; Provisional; Region: PRK03072 1097669001519 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK12439 1097669001520 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1097669001521 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1097669001522 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1097669001523 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1097669001524 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 1097669001525 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1097669001526 O-methyltransferase; Region: Methyltransf_2; pfam00891 1097669001527 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1097669001528 Cytochrome P450; Region: p450; cl12078 1097669001529 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 1097669001530 ATP cone domain; Region: ATP-cone; pfam03477 1097669001531 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 1097669001532 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 1097669001533 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 1097669001534 active site 1097669001535 dimer interface [polypeptide binding]; other site 1097669001536 effector binding site; other site 1097669001537 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1097669001538 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1097669001539 active site 1097669001540 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1097669001541 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1097669001542 nicotinate phosphoribosyltransferase; Provisional; Region: PRK12484 1097669001543 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1097669001544 active site 1097669001545 Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane]; Region: PgsA; COG2843 1097669001546 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 1097669001547 putative active site [active] 1097669001548 putative metal binding site [ion binding]; other site 1097669001549 hypothetical protein; Provisional; Region: PRK07588 1097669001550 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1097669001551 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1097669001552 dimerization interface [polypeptide binding]; other site 1097669001553 putative DNA binding site [nucleotide binding]; other site 1097669001554 putative Zn2+ binding site [ion binding]; other site 1097669001555 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1097669001556 putative hydrophobic ligand binding site [chemical binding]; other site 1097669001557 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1097669001558 TIGR03086 family protein; Region: TIGR03086 1097669001559 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1097669001560 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1097669001561 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1097669001562 Ub domain fused to Mut7-C; Region: Ub-Mut7C; pfam14451 1097669001563 Uncharacterized conserved protein [Function unknown]; Region: COG1656 1097669001564 Protein of unknown function DUF82; Region: DUF82; pfam01927 1097669001565 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1097669001566 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 1097669001567 putative active site [active] 1097669001568 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 1097669001569 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 1097669001570 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 1097669001571 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 1097669001572 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1097669001573 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1097669001574 DNA-binding site [nucleotide binding]; DNA binding site 1097669001575 FCD domain; Region: FCD; pfam07729 1097669001576 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1097669001577 Permease; Region: Permease; pfam02405 1097669001578 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1097669001579 Permease; Region: Permease; pfam02405 1097669001580 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1097669001581 mce related protein; Region: MCE; pfam02470 1097669001582 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1097669001583 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1097669001584 mce related protein; Region: MCE; pfam02470 1097669001585 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1097669001586 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1097669001587 mce related protein; Region: MCE; pfam02470 1097669001588 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1097669001589 mce related protein; Region: MCE; pfam02470 1097669001590 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1097669001591 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1097669001592 mce related protein; Region: MCE; pfam02470 1097669001593 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1097669001594 mce related protein; Region: MCE; pfam02470 1097669001595 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1097669001596 oligomeric interface; other site 1097669001597 putative active site [active] 1097669001598 homodimer interface [polypeptide binding]; other site 1097669001599 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1097669001600 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 1097669001601 AAA domain; Region: AAA_14; pfam13173 1097669001602 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1097669001603 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 1097669001604 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1097669001605 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1097669001606 ATP binding site [chemical binding]; other site 1097669001607 Mg2+ binding site [ion binding]; other site 1097669001608 G-X-G motif; other site 1097669001609 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1097669001610 dimerization interface [polypeptide binding]; other site 1097669001611 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1097669001612 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1097669001613 active site 1097669001614 phosphorylation site [posttranslational modification] 1097669001615 intermolecular recognition site; other site 1097669001616 dimerization interface [polypeptide binding]; other site 1097669001617 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1097669001618 DNA binding site [nucleotide binding] 1097669001619 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 1097669001620 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 1097669001621 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 1097669001622 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 1097669001623 catalytic residues [active] 1097669001624 catalytic nucleophile [active] 1097669001625 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1097669001626 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1097669001627 Probable transposase; Region: OrfB_IS605; pfam01385 1097669001628 Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704 1097669001629 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 1097669001630 putative active site [active] 1097669001631 SEC-C motif; Region: SEC-C; pfam02810 1097669001632 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB-like; cd09875 1097669001633 putative active site [active] 1097669001634 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 1097669001635 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 1097669001636 nucleotide binding site/active site [active] 1097669001638 galactokinase; Provisional; Region: PRK00555 1097669001639 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1097669001640 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1097669001641 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4423 1097669001642 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 1097669001643 putative active site [active] 1097669001644 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1097669001645 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1097669001646 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1097669001647 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1097669001648 oligomeric interface; other site 1097669001649 putative active site [active] 1097669001650 homodimer interface [polypeptide binding]; other site 1097669001651 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398 1097669001652 FIST N domain; Region: FIST; pfam08495 1097669001653 FIST C domain; Region: FIST_C; pfam10442 1097669001654 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 1097669001655 AAA domain; Region: AAA_30; pfam13604 1097669001656 Family description; Region: UvrD_C_2; pfam13538 1097669001657 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 1097669001658 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1097669001659 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 1097669001660 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 1097669001661 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1097669001662 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1097669001663 substrate binding site [chemical binding]; other site 1097669001664 oxyanion hole (OAH) forming residues; other site 1097669001665 trimer interface [polypeptide binding]; other site 1097669001666 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1097669001667 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 1097669001668 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 1097669001669 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1097669001670 active site 1097669001671 catalytic site [active] 1097669001672 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 1097669001673 active site 1097669001674 catalytic site [active] 1097669001675 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1097669001676 active site 1097669001677 catalytic site [active] 1097669001678 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 1097669001679 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1097669001680 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1097669001681 putative homodimer interface [polypeptide binding]; other site 1097669001682 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1097669001683 heterodimer interface [polypeptide binding]; other site 1097669001684 homodimer interface [polypeptide binding]; other site 1097669001685 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1097669001686 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1097669001687 23S rRNA interface [nucleotide binding]; other site 1097669001688 L7/L12 interface [polypeptide binding]; other site 1097669001689 putative thiostrepton binding site; other site 1097669001690 L25 interface [polypeptide binding]; other site 1097669001691 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1097669001692 mRNA/rRNA interface [nucleotide binding]; other site 1097669001693 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1097669001694 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1097669001695 S-adenosylmethionine binding site [chemical binding]; other site 1097669001696 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1097669001697 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1097669001698 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1097669001699 S-adenosylmethionine binding site [chemical binding]; other site 1097669001700 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1097669001701 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1097669001702 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1097669001703 S-adenosylmethionine binding site [chemical binding]; other site 1097669001704 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1097669001705 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1097669001706 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1097669001707 S-adenosylmethionine binding site [chemical binding]; other site 1097669001708 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1097669001709 TAP-like protein; Region: Abhydrolase_4; pfam08386 1097669001710 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 1097669001711 ABC1 family; Region: ABC1; cl17513 1097669001712 N-terminal catalytic domain of class II alpha-mannosidases and similar proteins; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_like; cd10786 1097669001713 active site 1097669001714 catalytic site [active] 1097669001715 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 1097669001716 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 1097669001717 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 1097669001718 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1097669001719 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1097669001720 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1097669001721 23S rRNA interface [nucleotide binding]; other site 1097669001722 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1097669001723 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1097669001724 core dimer interface [polypeptide binding]; other site 1097669001725 peripheral dimer interface [polypeptide binding]; other site 1097669001726 L10 interface [polypeptide binding]; other site 1097669001727 L11 interface [polypeptide binding]; other site 1097669001728 putative EF-Tu interaction site [polypeptide binding]; other site 1097669001729 putative EF-G interaction site [polypeptide binding]; other site 1097669001730 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1097669001731 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1097669001732 WHG domain; Region: WHG; pfam13305 1097669001733 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 1097669001734 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 1097669001735 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1097669001736 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1097669001737 Walker A/P-loop; other site 1097669001738 ATP binding site [chemical binding]; other site 1097669001739 Q-loop/lid; other site 1097669001740 ABC transporter signature motif; other site 1097669001741 Walker B; other site 1097669001742 D-loop; other site 1097669001743 H-loop/switch region; other site 1097669001744 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1097669001745 putative active site [active] 1097669001746 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 1097669001747 Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266 1097669001748 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 1097669001749 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG1848 1097669001750 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1097669001751 Sulfatase; Region: Sulfatase; pfam00884 1097669001752 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1097669001753 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1097669001754 putative active site [active] 1097669001755 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1097669001756 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1097669001757 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1097669001758 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1097669001759 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1097669001760 RPB10 interaction site [polypeptide binding]; other site 1097669001761 RPB1 interaction site [polypeptide binding]; other site 1097669001762 RPB11 interaction site [polypeptide binding]; other site 1097669001763 RPB3 interaction site [polypeptide binding]; other site 1097669001764 RPB12 interaction site [polypeptide binding]; other site 1097669001765 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1097669001766 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1097669001767 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1097669001768 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1097669001769 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 1097669001770 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1097669001771 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 1097669001772 G-loop; other site 1097669001773 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1097669001774 DNA binding site [nucleotide binding] 1097669001775 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1097669001776 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; pfam04734 1097669001777 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1097669001778 DNA interaction; other site 1097669001779 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 1097669001780 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 1097669001781 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 1097669001782 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1097669001783 active site 1097669001784 enoyl-CoA hydratase; Provisional; Region: PRK12478 1097669001785 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1097669001786 substrate binding site [chemical binding]; other site 1097669001787 oxyanion hole (OAH) forming residues; other site 1097669001788 trimer interface [polypeptide binding]; other site 1097669001789 Phenylacetic acid-responsive transcriptional repressor [Transcription]; Region: PaaX; COG3327 1097669001790 PaaX-like protein; Region: PaaX; pfam07848 1097669001791 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 1097669001792 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1097669001793 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1097669001794 substrate binding site [chemical binding]; other site 1097669001795 oxyanion hole (OAH) forming residues; other site 1097669001796 trimer interface [polypeptide binding]; other site 1097669001797 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1097669001798 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1097669001799 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 1097669001800 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 1097669001801 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1097669001802 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1097669001803 WHG domain; Region: WHG; pfam13305 1097669001804 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1097669001805 S17 interaction site [polypeptide binding]; other site 1097669001806 S8 interaction site; other site 1097669001807 16S rRNA interaction site [nucleotide binding]; other site 1097669001808 streptomycin interaction site [chemical binding]; other site 1097669001809 23S rRNA interaction site [nucleotide binding]; other site 1097669001810 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1097669001811 30S ribosomal protein S7; Validated; Region: PRK05302 1097669001812 elongation factor G; Reviewed; Region: PRK00007 1097669001813 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1097669001814 G1 box; other site 1097669001815 putative GEF interaction site [polypeptide binding]; other site 1097669001816 GTP/Mg2+ binding site [chemical binding]; other site 1097669001817 Switch I region; other site 1097669001818 G2 box; other site 1097669001819 G3 box; other site 1097669001820 Switch II region; other site 1097669001821 G4 box; other site 1097669001822 G5 box; other site 1097669001823 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1097669001824 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1097669001825 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1097669001826 elongation factor Tu; Reviewed; Region: PRK00049 1097669001827 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1097669001828 G1 box; other site 1097669001829 GEF interaction site [polypeptide binding]; other site 1097669001830 GTP/Mg2+ binding site [chemical binding]; other site 1097669001831 Switch I region; other site 1097669001832 G2 box; other site 1097669001833 G3 box; other site 1097669001834 Switch II region; other site 1097669001835 G4 box; other site 1097669001836 G5 box; other site 1097669001837 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 1097669001838 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1097669001839 Antibiotic Binding Site [chemical binding]; other site 1097669001840 Short C-terminal domain; Region: SHOCT; pfam09851 1097669001841 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1097669001842 classical (c) SDRs; Region: SDR_c; cd05233 1097669001843 NAD(P) binding site [chemical binding]; other site 1097669001844 active site 1097669001845 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1097669001846 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1097669001847 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4427 1097669001848 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1097669001849 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1097669001850 putative mycofactocin binding protein MftB; Region: mycofact_MftB; TIGR03967 1097669001851 mycofactocin radical SAM maturase; Region: mycofact_rSAM; TIGR03962 1097669001852 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1097669001853 FeS/SAM binding site; other site 1097669001854 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1097669001855 heme/flavin dehydrogenase, mycofactocin system; Region: actino_HemFlav; TIGR03966 1097669001856 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1097669001857 phosphate binding site [ion binding]; other site 1097669001858 mycofactocin system creatininase family protein; Region: mycofact_creat; TIGR03964 1097669001859 mycofactocin system glycosyltransferase; Region: mycofact_glyco; TIGR03965 1097669001860 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1097669001861 Probable Catalytic site; other site 1097669001862 metal-binding site 1097669001863 dehydrogenase, Rv0697 family; Region: Rv0697; TIGR03970 1097669001864 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1097669001865 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1097669001866 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1097669001867 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1097669001868 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1097669001869 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1097669001870 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1097669001871 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1097669001872 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1097669001873 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1097669001874 putative translocon binding site; other site 1097669001875 protein-rRNA interface [nucleotide binding]; other site 1097669001876 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1097669001877 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1097669001878 G-X-X-G motif; other site 1097669001879 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1097669001880 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1097669001881 23S rRNA interface [nucleotide binding]; other site 1097669001882 5S rRNA interface [nucleotide binding]; other site 1097669001883 putative antibiotic binding site [chemical binding]; other site 1097669001884 L25 interface [polypeptide binding]; other site 1097669001885 L27 interface [polypeptide binding]; other site 1097669001886 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1097669001887 putative translocon interaction site; other site 1097669001888 23S rRNA interface [nucleotide binding]; other site 1097669001889 signal recognition particle (SRP54) interaction site; other site 1097669001890 L23 interface [polypeptide binding]; other site 1097669001891 trigger factor interaction site; other site 1097669001892 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1097669001893 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1097669001894 Sulfatase; Region: Sulfatase; pfam00884 1097669001895 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl17353 1097669001896 Uncharacterized conserved protein [Function unknown]; Region: COG1262 1097669001897 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1097669001898 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1097669001899 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1097669001900 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1097669001901 RNA binding site [nucleotide binding]; other site 1097669001902 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1097669001903 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1097669001904 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1097669001905 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 1097669001906 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1097669001907 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1097669001908 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1097669001909 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1097669001910 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1097669001911 5S rRNA interface [nucleotide binding]; other site 1097669001912 23S rRNA interface [nucleotide binding]; other site 1097669001913 L5 interface [polypeptide binding]; other site 1097669001914 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1097669001915 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1097669001916 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1097669001917 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1097669001918 23S rRNA binding site [nucleotide binding]; other site 1097669001919 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1097669001920 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 1097669001921 tandem repeat interface [polypeptide binding]; other site 1097669001922 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1097669001923 oligomer interface [polypeptide binding]; other site 1097669001924 active site residues [active] 1097669001925 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1097669001926 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1097669001927 tandem repeat interface [polypeptide binding]; other site 1097669001928 oligomer interface [polypeptide binding]; other site 1097669001929 active site residues [active] 1097669001931 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1097669001932 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1097669001933 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1097669001934 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1097669001935 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1097669001936 intersubunit interface [polypeptide binding]; other site 1097669001937 active site 1097669001938 Zn2+ binding site [ion binding]; other site 1097669001939 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1097669001940 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1097669001941 NAD binding site [chemical binding]; other site 1097669001942 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1097669001943 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1097669001944 nucleotide binding site [chemical binding]; other site 1097669001945 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1097669001946 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1097669001947 Coenzyme A binding pocket [chemical binding]; other site 1097669001948 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1097669001949 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1097669001950 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1097669001951 SecY translocase; Region: SecY; pfam00344 1097669001952 adenylate kinase; Reviewed; Region: adk; PRK00279 1097669001953 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1097669001954 AMP-binding site [chemical binding]; other site 1097669001955 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1097669001956 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1097669001957 active site 1097669001958 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 1097669001959 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1097669001960 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1097669001961 DNA binding residues [nucleotide binding] 1097669001962 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 1097669001963 Putative zinc-finger; Region: zf-HC2; pfam13490 1097669001964 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1097669001965 MarR family; Region: MarR; pfam01047 1097669001966 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1097669001967 TIGR03086 family protein; Region: TIGR03086 1097669001968 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 1097669001969 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1097669001970 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1097669001971 Helix-turn-helix domain; Region: HTH_17; pfam12728 1097669001972 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 1097669001973 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1097669001974 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 1097669001975 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1097669001976 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 1097669001977 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1097669001978 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1097669001979 active site 1097669001980 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1097669001981 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1097669001982 tetrameric interface [polypeptide binding]; other site 1097669001983 NAD binding site [chemical binding]; other site 1097669001984 catalytic residues [active] 1097669001985 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1097669001986 catalytic core [active] 1097669001987 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1097669001988 PPE family; Region: PPE; pfam00823 1097669001989 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1097669001990 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1097669001991 Helix-turn-helix domain; Region: HTH_28; pfam13518 1097669001992 Winged helix-turn helix; Region: HTH_29; pfam13551 1097669001993 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1097669001994 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1097669001995 active site 1097669001996 phosphorylation site [posttranslational modification] 1097669001997 intermolecular recognition site; other site 1097669001998 dimerization interface [polypeptide binding]; other site 1097669001999 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1097669002000 DNA binding site [nucleotide binding] 1097669002001 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1097669002002 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1097669002003 dimerization interface [polypeptide binding]; other site 1097669002004 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1097669002005 dimer interface [polypeptide binding]; other site 1097669002006 phosphorylation site [posttranslational modification] 1097669002007 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1097669002008 ATP binding site [chemical binding]; other site 1097669002009 Mg2+ binding site [ion binding]; other site 1097669002010 G-X-G motif; other site 1097669002011 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 1097669002012 nucleotide binding site/active site [active] 1097669002013 HIT family signature motif; other site 1097669002014 catalytic residue [active] 1097669002015 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 1097669002016 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 1097669002017 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1097669002018 NAD binding site [chemical binding]; other site 1097669002019 catalytic Zn binding site [ion binding]; other site 1097669002020 substrate binding site [chemical binding]; other site 1097669002021 structural Zn binding site [ion binding]; other site 1097669002022 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1097669002023 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1097669002024 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 1097669002025 short chain dehydrogenase; Provisional; Region: PRK07775 1097669002026 classical (c) SDRs; Region: SDR_c; cd05233 1097669002027 NAD(P) binding site [chemical binding]; other site 1097669002028 active site 1097669002029 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1097669002030 Cytochrome P450; Region: p450; cl12078 1097669002031 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1097669002032 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 1097669002033 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 1097669002034 NAD binding site [chemical binding]; other site 1097669002035 catalytic residues [active] 1097669002036 short chain dehydrogenase; Provisional; Region: PRK07774 1097669002037 classical (c) SDRs; Region: SDR_c; cd05233 1097669002038 NAD(P) binding site [chemical binding]; other site 1097669002039 active site 1097669002040 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1097669002041 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 1097669002042 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1097669002043 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1097669002044 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1097669002045 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1097669002046 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1097669002047 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1097669002048 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1097669002049 Predicted esterase [General function prediction only]; Region: COG0627 1097669002050 S-formylglutathione hydrolase; Region: PLN02442 1097669002051 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 1097669002052 Predicted nuclease (RNAse H fold) [General function prediction only]; Region: COG4328 1097669002053 Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302 1097669002054 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 1097669002055 tetramer interface [polypeptide binding]; other site 1097669002056 active site 1097669002057 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1097669002058 Cytochrome P450; Region: p450; cl12078 1097669002059 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 1097669002060 ATP binding site [chemical binding]; other site 1097669002061 active site 1097669002062 substrate binding site [chemical binding]; other site 1097669002063 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 1097669002064 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1097669002065 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1097669002066 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1097669002067 putative substrate translocation pore; other site 1097669002068 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1097669002069 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374 1097669002070 putative active site [active] 1097669002071 putative Zn binding site [ion binding]; other site 1097669002072 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1097669002073 FAD binding domain; Region: FAD_binding_2; pfam00890 1097669002074 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1097669002075 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 1097669002076 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1097669002077 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1097669002078 putative active site [active] 1097669002079 catalytic triad [active] 1097669002080 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1097669002081 Transglutaminase/protease-like homologues; Region: TGc; smart00460 1097669002082 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1097669002083 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 1097669002084 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1097669002085 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1097669002086 DNA-binding site [nucleotide binding]; DNA binding site 1097669002087 UTRA domain; Region: UTRA; pfam07702 1097669002088 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1097669002089 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 1097669002090 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1097669002091 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1097669002092 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1097669002093 Uncharacterized protein, linocin/CFP29 homolog [Function unknown]; Region: COG1659 1097669002094 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 1097669002095 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 1097669002096 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 1097669002097 active site 1097669002098 metal binding site [ion binding]; metal-binding site 1097669002099 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1097669002100 active site 1097669002101 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1097669002102 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1097669002103 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1097669002104 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1097669002105 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1097669002106 dimerization interface [polypeptide binding]; other site 1097669002107 ATP binding site [chemical binding]; other site 1097669002108 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1097669002109 dimerization interface [polypeptide binding]; other site 1097669002110 ATP binding site [chemical binding]; other site 1097669002111 CAAX protease self-immunity; Region: Abi; pfam02517 1097669002112 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 1097669002113 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 1097669002114 active site 1097669002115 metal binding site [ion binding]; metal-binding site 1097669002116 hexamer interface [polypeptide binding]; other site 1097669002117 Protein of unknown function (DUF3184); Region: DUF3184; pfam11380 1097669002118 amidophosphoribosyltransferase; Provisional; Region: PRK07847 1097669002119 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1097669002120 active site 1097669002121 tetramer interface [polypeptide binding]; other site 1097669002122 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1097669002123 active site 1097669002124 phosphoribosylaminoimidazole synthetase; Region: purM; TIGR00878 1097669002125 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1097669002126 dimerization interface [polypeptide binding]; other site 1097669002127 putative ATP binding site [chemical binding]; other site 1097669002128 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 1097669002129 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 1097669002130 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1097669002131 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1097669002132 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1097669002133 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1097669002134 catalytic residue [active] 1097669002135 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 1097669002136 heme-binding site [chemical binding]; other site 1097669002137 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1097669002138 catalytic residues [active] 1097669002139 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1097669002140 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1097669002141 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1097669002142 DNA binding site [nucleotide binding] 1097669002143 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 1097669002144 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1097669002145 Coenzyme A binding pocket [chemical binding]; other site 1097669002146 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 1097669002147 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1097669002148 Walker A/P-loop; other site 1097669002149 ATP binding site [chemical binding]; other site 1097669002150 Q-loop/lid; other site 1097669002151 ABC transporter signature motif; other site 1097669002152 Walker B; other site 1097669002153 D-loop; other site 1097669002154 H-loop/switch region; other site 1097669002155 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1097669002156 PhoU domain; Region: PhoU; pfam01895 1097669002157 PhoU domain; Region: PhoU; pfam01895 1097669002158 cell envelope-related function transcriptional attenuator common domain; Region: lytR_cpsA_psr; TIGR00350 1097669002159 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1097669002160 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1097669002161 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1097669002162 FMN binding site [chemical binding]; other site 1097669002163 active site 1097669002164 catalytic residues [active] 1097669002165 substrate binding site [chemical binding]; other site 1097669002166 Fatty acid desaturase; Region: FA_desaturase_2; pfam03405 1097669002167 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 1097669002168 homodimer interface [polypeptide binding]; other site 1097669002169 putative substrate binding pocket [chemical binding]; other site 1097669002170 diiron center [ion binding]; other site 1097669002171 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 1097669002172 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1097669002173 dimerization interface [polypeptide binding]; other site 1097669002174 putative DNA binding site [nucleotide binding]; other site 1097669002175 putative Zn2+ binding site [ion binding]; other site 1097669002176 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1097669002177 dimer interface [polypeptide binding]; other site 1097669002178 catalytic motif [active] 1097669002179 nucleoside/Zn binding site; other site 1097669002180 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1097669002181 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1097669002182 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1097669002183 TIGR04255 family protein; Region: sporadTIGR04255 1097669002184 PknH-like extracellular domain; Region: PknH_C; pfam14032 1097669002185 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4861 1097669002186 Uncharacterized protein conserved in bacteria (DUF2186); Region: DUF2186; pfam09952 1097669002187 D-ala-D-ala dipeptidase; Region: Peptidase_M15; pfam01427 1097669002188 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1097669002189 S-adenosylmethionine binding site [chemical binding]; other site 1097669002190 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 1097669002191 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1097669002192 putative substrate translocation pore; other site 1097669002193 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1097669002194 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 1097669002195 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1097669002196 tetramer interface [polypeptide binding]; other site 1097669002197 TPP-binding site [chemical binding]; other site 1097669002198 heterodimer interface [polypeptide binding]; other site 1097669002199 phosphorylation loop region [posttranslational modification] 1097669002200 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1097669002201 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1097669002202 active site 1097669002203 phosphorylation site [posttranslational modification] 1097669002204 intermolecular recognition site; other site 1097669002205 dimerization interface [polypeptide binding]; other site 1097669002206 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1097669002207 DNA binding residues [nucleotide binding] 1097669002208 dimerization interface [polypeptide binding]; other site 1097669002209 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1097669002210 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1097669002211 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1097669002212 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1097669002213 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1097669002214 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1097669002215 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1097669002216 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1097669002217 dimer interface [polypeptide binding]; other site 1097669002218 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1097669002219 catalytic residue [active] 1097669002220 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1097669002221 multidrug resistance protein MdtH; Provisional; Region: PRK11646 1097669002222 putative substrate translocation pore; other site 1097669002223 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 1097669002224 short chain dehydrogenase; Provisional; Region: PRK05876 1097669002225 classical (c) SDRs; Region: SDR_c; cd05233 1097669002226 NAD(P) binding site [chemical binding]; other site 1097669002227 active site 1097669002228 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1097669002229 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 1097669002230 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 1097669002231 dimer interface [polypeptide binding]; other site 1097669002232 PYR/PP interface [polypeptide binding]; other site 1097669002233 TPP binding site [chemical binding]; other site 1097669002234 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1097669002235 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 1097669002236 TPP-binding site [chemical binding]; other site 1097669002237 dimer interface [polypeptide binding]; other site 1097669002238 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1097669002239 putative hydrophobic ligand binding site [chemical binding]; other site 1097669002240 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1097669002241 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1097669002242 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1097669002243 putative hydrophobic ligand binding site [chemical binding]; other site 1097669002244 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1097669002245 putative hydrophobic ligand binding site [chemical binding]; other site 1097669002246 aminotransferase; Validated; Region: PRK07777 1097669002247 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1097669002248 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1097669002249 homodimer interface [polypeptide binding]; other site 1097669002250 catalytic residue [active] 1097669002251 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 1097669002252 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1097669002253 dimer interface [polypeptide binding]; other site 1097669002254 active site 1097669002255 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 1097669002256 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1097669002257 substrate binding site [chemical binding]; other site 1097669002258 oxyanion hole (OAH) forming residues; other site 1097669002259 trimer interface [polypeptide binding]; other site 1097669002260 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1097669002261 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1097669002262 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1097669002263 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1097669002264 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1097669002265 ATP binding site [chemical binding]; other site 1097669002266 putative Mg++ binding site [ion binding]; other site 1097669002267 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1097669002268 nucleotide binding region [chemical binding]; other site 1097669002269 ATP-binding site [chemical binding]; other site 1097669002270 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1097669002271 WYL domain; Region: WYL; pfam13280 1097669002272 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1097669002273 trimer interface [polypeptide binding]; other site 1097669002274 dimer interface [polypeptide binding]; other site 1097669002275 putative active site [active] 1097669002276 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1097669002277 MPT binding site; other site 1097669002278 trimer interface [polypeptide binding]; other site 1097669002279 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1097669002280 MoaE homodimer interface [polypeptide binding]; other site 1097669002281 MoaD interaction [polypeptide binding]; other site 1097669002282 active site residues [active] 1097669002283 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1097669002284 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1097669002285 MoaE interaction surface [polypeptide binding]; other site 1097669002286 MoeB interaction surface [polypeptide binding]; other site 1097669002287 thiocarboxylated glycine; other site 1097669002288 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1097669002289 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1097669002290 FeS/SAM binding site; other site 1097669002291 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1097669002292 hypothetical protein; Provisional; Region: PRK11770 1097669002293 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1097669002294 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1097669002295 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1097669002296 DNA-binding site [nucleotide binding]; DNA binding site 1097669002297 RNA-binding motif; other site 1097669002298 PE family; Region: PE; pfam00934 1097669002299 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1097669002300 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1097669002301 active site 1097669002302 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398 1097669002303 FIST N domain; Region: FIST; pfam08495 1097669002304 FIST C domain; Region: FIST_C; pfam10442 1097669002305 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 1097669002306 H+ Antiporter protein; Region: 2A0121; TIGR00900 1097669002307 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 1097669002308 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1097669002309 PPE family; Region: PPE; pfam00823 1097669002310 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1097669002311 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1097669002312 Protein of unknown function (DUF2530); Region: DUF2530; pfam10745 1097669002313 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1097669002314 MarR family; Region: MarR; pfam01047 1097669002315 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1097669002316 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1097669002317 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1097669002318 Protein of unknown function (DUF2537); Region: DUF2537; pfam10801 1097669002319 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 1097669002320 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1097669002321 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1097669002322 catalytic residue [active] 1097669002323 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 1097669002324 Ferredoxin [Energy production and conversion]; Region: COG1146 1097669002325 4Fe-4S binding domain; Region: Fer4; pfam00037 1097669002326 ferredoxin-NADP+ reductase; Region: PLN02852 1097669002327 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1097669002328 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 1097669002329 putative dimer interface [polypeptide binding]; other site 1097669002330 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1097669002331 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1097669002332 putative catalytic site [active] 1097669002333 putative phosphate binding site [ion binding]; other site 1097669002334 putative metal binding site [ion binding]; other site 1097669002335 Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109 1097669002336 dimer interface [polypeptide binding]; other site 1097669002337 Citrate synthase; Region: Citrate_synt; pfam00285 1097669002338 active site 1097669002339 citrylCoA binding site [chemical binding]; other site 1097669002340 oxalacetate/citrate binding site [chemical binding]; other site 1097669002341 coenzyme A binding site [chemical binding]; other site 1097669002342 catalytic triad [active] 1097669002343 Predicted ATPase [General function prediction only]; Region: COG3903 1097669002344 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1097669002345 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1097669002346 DNA binding residues [nucleotide binding] 1097669002347 dimerization interface [polypeptide binding]; other site 1097669002348 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1097669002349 cyclase homology domain; Region: CHD; cd07302 1097669002350 nucleotidyl binding site; other site 1097669002351 metal binding site [ion binding]; metal-binding site 1097669002352 dimer interface [polypeptide binding]; other site 1097669002353 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1097669002354 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1097669002355 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1097669002356 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1097669002357 AAA ATPase domain; Region: AAA_16; pfam13191 1097669002358 Predicted ATPase [General function prediction only]; Region: COG3903 1097669002359 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1097669002360 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1097669002361 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1097669002362 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1097669002363 dimer interface [polypeptide binding]; other site 1097669002364 active site 1097669002365 citrylCoA binding site [chemical binding]; other site 1097669002366 NADH binding [chemical binding]; other site 1097669002367 cationic pore residues; other site 1097669002368 oxalacetate/citrate binding site [chemical binding]; other site 1097669002369 coenzyme A binding site [chemical binding]; other site 1097669002370 catalytic triad [active] 1097669002371 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1097669002372 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1097669002373 Protein of unknown function (DUF2630); Region: DUF2630; pfam10944 1097669002374 BON domain; Region: BON; pfam04972 1097669002375 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1097669002376 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1097669002377 ligand binding site [chemical binding]; other site 1097669002378 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 1097669002379 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1097669002380 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1097669002381 dimerization interface [polypeptide binding]; other site 1097669002382 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1097669002383 dimer interface [polypeptide binding]; other site 1097669002384 phosphorylation site [posttranslational modification] 1097669002385 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1097669002386 Mg2+ binding site [ion binding]; other site 1097669002387 G-X-G motif; other site 1097669002388 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1097669002389 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1097669002390 active site 1097669002391 phosphorylation site [posttranslational modification] 1097669002392 intermolecular recognition site; other site 1097669002393 dimerization interface [polypeptide binding]; other site 1097669002394 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1097669002395 DNA binding site [nucleotide binding] 1097669002396 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 1097669002397 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; COG0825 1097669002398 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1097669002399 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1097669002400 substrate binding site [chemical binding]; other site 1097669002401 oxyanion hole (OAH) forming residues; other site 1097669002402 trimer interface [polypeptide binding]; other site 1097669002403 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1097669002404 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1097669002405 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1097669002406 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1097669002407 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1097669002408 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 1097669002409 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1097669002410 hydrophobic ligand binding site; other site 1097669002411 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1097669002412 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1097669002413 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1097669002414 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1097669002415 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 1097669002416 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 1097669002417 acetyl-CoA acetyltransferase; Provisional; Region: PRK06289 1097669002418 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1097669002419 active site 1097669002420 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1097669002421 PPE family; Region: PPE; pfam00823 1097669002422 PE family; Region: PE; pfam00934 1097669002423 BCCT family transporter; Region: BCCT; pfam02028 1097669002424 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 1097669002425 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1097669002426 Coenzyme A binding pocket [chemical binding]; other site 1097669002427 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1097669002428 MULE transposase domain; Region: MULE; pfam10551 1097669002429 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 1097669002430 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 1097669002431 catalytic residues [active] 1097669002432 catalytic nucleophile [active] 1097669002433 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1097669002434 Probable transposase; Region: OrfB_IS605; pfam01385 1097669002435 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1097669002436 putative active site pocket [active] 1097669002437 dimerization interface [polypeptide binding]; other site 1097669002438 putative catalytic residue [active] 1097669002439 Phage-related replication protein [General function prediction only]; Region: COG4195 1097669002440 manganese transport protein MntH; Reviewed; Region: PRK00701 1097669002441 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1097669002442 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1097669002443 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1097669002444 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1097669002445 short chain dehydrogenase; Provisional; Region: PRK07814 1097669002446 classical (c) SDRs; Region: SDR_c; cd05233 1097669002447 NAD(P) binding site [chemical binding]; other site 1097669002448 active site 1097669002449 phosphate ABC transporter, phosphate-binding protein; Region: 3a0107s03; TIGR00975 1097669002450 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 1097669002451 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1097669002452 dimer interface [polypeptide binding]; other site 1097669002453 conserved gate region; other site 1097669002454 putative PBP binding loops; other site 1097669002455 ABC-ATPase subunit interface; other site 1097669002456 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1097669002457 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1097669002458 dimer interface [polypeptide binding]; other site 1097669002459 conserved gate region; other site 1097669002460 putative PBP binding loops; other site 1097669002461 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1097669002462 ABC-ATPase subunit interface; other site 1097669002463 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1097669002464 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1097669002465 active site 1097669002466 ATP binding site [chemical binding]; other site 1097669002467 substrate binding site [chemical binding]; other site 1097669002468 activation loop (A-loop); other site 1097669002469 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1097669002470 NHL repeat; Region: NHL; pfam01436 1097669002471 NHL repeat; Region: NHL; pfam01436 1097669002472 NHL repeat; Region: NHL; pfam01436 1097669002473 NHL repeat; Region: NHL; pfam01436 1097669002474 NHL repeat; Region: NHL; pfam01436 1097669002475 PBP superfamily domain; Region: PBP_like_2; cl17296 1097669002476 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14271 1097669002477 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1097669002478 Walker A/P-loop; other site 1097669002479 ATP binding site [chemical binding]; other site 1097669002480 Q-loop/lid; other site 1097669002481 ABC transporter signature motif; other site 1097669002482 Walker B; other site 1097669002483 D-loop; other site 1097669002484 H-loop/switch region; other site 1097669002485 phosphate ABC transporter, phosphate-binding protein; Region: 3a0107s03; TIGR00975 1097669002486 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 1097669002487 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1097669002488 dimer interface [polypeptide binding]; other site 1097669002489 conserved gate region; other site 1097669002490 putative PBP binding loops; other site 1097669002491 ABC-ATPase subunit interface; other site 1097669002492 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1097669002493 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1097669002494 dimer interface [polypeptide binding]; other site 1097669002495 conserved gate region; other site 1097669002496 putative PBP binding loops; other site 1097669002497 ABC-ATPase subunit interface; other site 1097669002498 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 1097669002499 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 1097669002500 putative DNA binding site [nucleotide binding]; other site 1097669002501 putative homodimer interface [polypeptide binding]; other site 1097669002502 ATP-dependent DNA ligase; Reviewed; Region: PRK09632 1097669002503 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 1097669002504 nucleotide binding site [chemical binding]; other site 1097669002505 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 1097669002506 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 1097669002507 active site 1097669002508 DNA binding site [nucleotide binding] 1097669002509 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 1097669002510 DNA binding site [nucleotide binding] 1097669002511 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1097669002512 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1097669002513 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1097669002514 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1097669002515 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1097669002516 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1097669002517 anti sigma factor interaction site; other site 1097669002518 regulatory phosphorylation site [posttranslational modification]; other site 1097669002519 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1097669002520 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1097669002521 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1097669002522 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1097669002523 short chain dehydrogenase; Provisional; Region: PRK08251 1097669002524 classical (c) SDR, subgroup 6; Region: SDR_c6; cd05350 1097669002525 putative NAD(P) binding site [chemical binding]; other site 1097669002526 active site 1097669002527 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1097669002528 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1097669002529 active site 1097669002530 dimer interface [polypeptide binding]; other site 1097669002531 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1097669002532 dimer interface [polypeptide binding]; other site 1097669002533 active site 1097669002534 pseudo 1097669002535 hypothetical protein; Provisional; Region: PRK07857 1097669002536 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1097669002537 Part of AAA domain; Region: AAA_19; pfam13245 1097669002538 Family description; Region: UvrD_C_2; pfam13538 1097669002539 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1097669002540 Peptidase family M23; Region: Peptidase_M23; pfam01551 1097669002541 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1097669002542 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1097669002543 CoA-ligase; Region: Ligase_CoA; pfam00549 1097669002544 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1097669002545 CoA binding domain; Region: CoA_binding; smart00881 1097669002546 CoA-ligase; Region: Ligase_CoA; pfam00549 1097669002547 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1097669002548 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1097669002549 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1097669002550 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1097669002551 active site 1097669002552 substrate binding site [chemical binding]; other site 1097669002553 cosubstrate binding site; other site 1097669002554 catalytic site [active] 1097669002555 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1097669002556 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1097669002557 purine monophosphate binding site [chemical binding]; other site 1097669002558 dimer interface [polypeptide binding]; other site 1097669002559 putative catalytic residues [active] 1097669002560 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1097669002561 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1097669002562 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 1097669002563 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1097669002564 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 1097669002565 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1097669002566 metal ion-dependent adhesion site (MIDAS); other site 1097669002567 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 1097669002568 homotetrameric interface [polypeptide binding]; other site 1097669002569 putative active site [active] 1097669002570 metal binding site [ion binding]; metal-binding site 1097669002571 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 1097669002572 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1097669002573 Thermus thermophilus CsoR, a Cu(I)-sensing transcriptional regulator, and related domains; this domain family was previously known as part of DUF156; Region: TthCsoR-like_DUF156; cd10151 1097669002574 putative homodimer interface [polypeptide binding]; other site 1097669002575 putative homotetramer interface [polypeptide binding]; other site 1097669002576 allosteric switch controlling residues; other site 1097669002577 putative metal binding site [ion binding]; other site 1097669002578 putative homodimer-homodimer interface [polypeptide binding]; other site 1097669002579 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 1097669002580 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 1097669002581 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1097669002582 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1097669002583 enoyl-CoA hydratase; Provisional; Region: PRK07827 1097669002584 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1097669002585 substrate binding site [chemical binding]; other site 1097669002586 oxyanion hole (OAH) forming residues; other site 1097669002587 trimer interface [polypeptide binding]; other site 1097669002588 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1097669002589 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1097669002590 active site 1097669002591 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1097669002592 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1097669002593 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1097669002594 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1097669002595 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1097669002596 carboxyltransferase (CT) interaction site; other site 1097669002597 biotinylation site [posttranslational modification]; other site 1097669002598 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1097669002599 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1097669002600 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1097669002601 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1097669002602 active site 1097669002603 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 1097669002604 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1097669002605 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1097669002606 active site 1097669002607 phosphorylation site [posttranslational modification] 1097669002608 intermolecular recognition site; other site 1097669002609 dimerization interface [polypeptide binding]; other site 1097669002610 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1097669002611 DNA binding site [nucleotide binding] 1097669002612 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1097669002613 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1097669002614 dimerization interface [polypeptide binding]; other site 1097669002615 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1097669002616 dimer interface [polypeptide binding]; other site 1097669002617 phosphorylation site [posttranslational modification] 1097669002618 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1097669002619 ATP binding site [chemical binding]; other site 1097669002620 Mg2+ binding site [ion binding]; other site 1097669002621 G-X-G motif; other site 1097669002622 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 1097669002623 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1097669002624 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1097669002625 MPT binding site; other site 1097669002626 trimer interface [polypeptide binding]; other site 1097669002627 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1097669002628 Large-conductance mechanosensitive channel, MscL; Region: MscL; pfam01741 1097669002629 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1097669002630 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1097669002631 Walker A/P-loop; other site 1097669002632 ATP binding site [chemical binding]; other site 1097669002633 Q-loop/lid; other site 1097669002634 ABC transporter signature motif; other site 1097669002635 Walker B; other site 1097669002636 D-loop; other site 1097669002637 H-loop/switch region; other site 1097669002638 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1097669002639 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1097669002640 FtsX-like permease family; Region: FtsX; pfam02687 1097669002641 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1097669002642 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1097669002643 FtsX-like permease family; Region: FtsX; pfam02687 1097669002644 Predicted secreted hydrolase [General function prediction only]; Region: COG5621 1097669002645 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1097669002646 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1097669002647 substrate binding pocket [chemical binding]; other site 1097669002648 chain length determination region; other site 1097669002649 substrate-Mg2+ binding site; other site 1097669002650 catalytic residues [active] 1097669002651 aspartate-rich region 1; other site 1097669002652 active site lid residues [active] 1097669002653 aspartate-rich region 2; other site 1097669002654 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1097669002655 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2331 1097669002656 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 1097669002657 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1097669002658 UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210 1097669002659 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1097669002660 active site 1097669002661 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1097669002662 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1097669002663 dimer interface [polypeptide binding]; other site 1097669002664 putative functional site; other site 1097669002665 putative MPT binding site; other site 1097669002666 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1097669002667 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1097669002668 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1097669002669 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1097669002670 ligand binding site [chemical binding]; other site 1097669002671 flexible hinge region; other site 1097669002672 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1097669002673 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1097669002674 Coenzyme A binding pocket [chemical binding]; other site 1097669002675 Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145 1097669002676 arginine deiminase; Provisional; Region: PRK01388 1097669002677 Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928 1097669002678 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1097669002679 Predicted methyltransferases [General function prediction only]; Region: COG0313 1097669002680 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1097669002681 putative SAM binding site [chemical binding]; other site 1097669002682 putative homodimer interface [polypeptide binding]; other site 1097669002683 aminodeoxychorismate synthase component I; Provisional; Region: PRK05877 1097669002684 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 1097669002685 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 1097669002686 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1097669002687 active site 1097669002688 HIGH motif; other site 1097669002689 KMSKS motif; other site 1097669002690 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1097669002691 tRNA binding surface [nucleotide binding]; other site 1097669002692 anticodon binding site; other site 1097669002693 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1097669002694 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1097669002695 active site 1097669002696 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 1097669002697 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1097669002698 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1097669002699 G5 domain; Region: G5; pfam07501 1097669002700 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1097669002701 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1097669002702 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1097669002703 S-adenosylmethionine binding site [chemical binding]; other site 1097669002704 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 1097669002705 Increased loss of mitochondrial DNA protein 1; Region: Ilm1; pfam10311 1097669002706 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1097669002707 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 1097669002708 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1097669002709 acyl-activating enzyme (AAE) consensus motif; other site 1097669002710 AMP binding site [chemical binding]; other site 1097669002711 active site 1097669002712 CoA binding site [chemical binding]; other site 1097669002713 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1097669002714 putative active site [active] 1097669002715 catalytic residue [active] 1097669002716 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1097669002717 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 1097669002718 5S rRNA interface [nucleotide binding]; other site 1097669002719 CTC domain interface [polypeptide binding]; other site 1097669002720 L16 interface [polypeptide binding]; other site 1097669002721 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 1097669002722 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1097669002723 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 1097669002724 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1097669002725 active site 1097669002726 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 1097669002727 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1097669002728 Substrate binding site; other site 1097669002729 Mg++ binding site; other site 1097669002730 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1097669002731 active site 1097669002732 substrate binding site [chemical binding]; other site 1097669002733 CoA binding site [chemical binding]; other site 1097669002734 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1097669002735 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1097669002736 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1097669002737 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1097669002738 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1097669002739 ATP binding site [chemical binding]; other site 1097669002740 putative Mg++ binding site [ion binding]; other site 1097669002741 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1097669002742 nucleotide binding region [chemical binding]; other site 1097669002743 ATP-binding site [chemical binding]; other site 1097669002744 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1097669002745 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334 1097669002746 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1097669002747 homodimer interface [polypeptide binding]; other site 1097669002748 metal binding site [ion binding]; metal-binding site 1097669002749 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 1097669002750 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 1097669002751 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1097669002752 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1097669002753 enolase; Provisional; Region: eno; PRK00077 1097669002754 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1097669002755 dimer interface [polypeptide binding]; other site 1097669002756 metal binding site [ion binding]; metal-binding site 1097669002757 substrate binding pocket [chemical binding]; other site 1097669002758 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1097669002759 Septum formation initiator; Region: DivIC; pfam04977 1097669002760 Uncharacterized conserved protein [Function unknown]; Region: COG1507 1097669002761 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1097669002762 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1097669002763 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 1097669002764 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1097669002765 active site 1097669002766 phosphorylation site [posttranslational modification] 1097669002767 intermolecular recognition site; other site 1097669002768 dimerization interface [polypeptide binding]; other site 1097669002769 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1097669002770 DNA binding site [nucleotide binding] 1097669002771 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 1097669002772 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1097669002773 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1097669002774 Ligand Binding Site [chemical binding]; other site 1097669002775 K+-transporting ATPase, KdpA; Region: kdpA; TIGR00680 1097669002776 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 1097669002777 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1097669002778 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1097669002779 potassium-transporting ATPase subunit C; Provisional; Region: PRK14001 1097669002780 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1097669002781 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1097669002782 dimer interface [polypeptide binding]; other site 1097669002783 phosphorylation site [posttranslational modification] 1097669002784 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1097669002785 ATP binding site [chemical binding]; other site 1097669002786 Mg2+ binding site [ion binding]; other site 1097669002787 G-X-G motif; other site 1097669002788 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1097669002789 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1097669002790 active site 1097669002791 phosphorylation site [posttranslational modification] 1097669002792 intermolecular recognition site; other site 1097669002793 dimerization interface [polypeptide binding]; other site 1097669002794 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1097669002795 DNA binding site [nucleotide binding] 1097669002796 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 1097669002797 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 1097669002798 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1097669002799 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1097669002800 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1097669002801 PPE family; Region: PPE; pfam00823 1097669002802 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1097669002803 PE family; Region: PE; pfam00934 1097669002804 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1097669002805 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1097669002806 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1097669002807 Predicted transcriptional regulator [Transcription]; Region: COG5340 1097669002808 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1097669002809 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 1097669002810 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1097669002811 MarR family; Region: MarR_2; pfam12802 1097669002812 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1097669002813 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1097669002814 NAD(P) binding site [chemical binding]; other site 1097669002815 active site 1097669002816 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 1097669002817 Helix-turn-helix domain; Region: HTH_17; pfam12728 1097669002818 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1097669002819 Domain of unknown function (DUF427); Region: DUF427; cl00998 1097669002820 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 1097669002821 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1097669002822 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1097669002823 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 1097669002824 dimer interface [polypeptide binding]; other site 1097669002825 acyl-activating enzyme (AAE) consensus motif; other site 1097669002826 putative active site [active] 1097669002827 AMP binding site [chemical binding]; other site 1097669002828 putative CoA binding site [chemical binding]; other site 1097669002829 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1097669002830 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 1097669002831 hydrophobic ligand binding site; other site 1097669002832 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 1097669002833 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1097669002834 putative active site [active] 1097669002835 putative dimer interface [polypeptide binding]; other site 1097669002836 Patatin-like phospholipase; Region: Patatin; pfam01734 1097669002837 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1097669002838 nucleophile elbow; other site 1097669002839 hypothetical protein; Provisional; Region: PRK10279 1097669002840 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 1097669002841 active site 1097669002842 nucleophile elbow; other site 1097669002843 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 1097669002844 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1097669002845 active site residue [active] 1097669002846 Predicted membrane protein [Function unknown]; Region: COG4425 1097669002847 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 1097669002848 enoyl-CoA hydratase; Provisional; Region: PRK05862 1097669002849 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1097669002850 substrate binding site [chemical binding]; other site 1097669002851 oxyanion hole (OAH) forming residues; other site 1097669002852 trimer interface [polypeptide binding]; other site 1097669002853 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 1097669002854 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1097669002855 substrate binding site [chemical binding]; other site 1097669002856 oxyanion hole (OAH) forming residues; other site 1097669002857 trimer interface [polypeptide binding]; other site 1097669002858 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 1097669002859 Predicted membrane protein [Function unknown]; Region: COG4760 1097669002860 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1097669002861 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1097669002862 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 1097669002863 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1097669002864 dimer interface [polypeptide binding]; other site 1097669002865 active site 1097669002866 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 1097669002867 active site 1097669002868 catalytic triad [active] 1097669002869 oxyanion hole [active] 1097669002870 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1097669002871 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1097669002872 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 1097669002873 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1097669002874 dimer interface [polypeptide binding]; other site 1097669002875 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1097669002876 catalytic residue [active] 1097669002877 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 1097669002878 RDD family; Region: RDD; pfam06271 1097669002879 cystathionine gamma-synthase; Provisional; Region: PRK07811 1097669002880 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1097669002881 homodimer interface [polypeptide binding]; other site 1097669002882 substrate-cofactor binding pocket; other site 1097669002883 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1097669002884 catalytic residue [active] 1097669002885 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1097669002886 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1097669002887 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1097669002888 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 1097669002889 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 1097669002890 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 1097669002891 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 1097669002892 catalytic residues [active] 1097669002893 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 1097669002894 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1097669002895 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1097669002896 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1097669002897 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1097669002898 catalytic residue [active] 1097669002899 putative FPP diphosphate binding site; other site 1097669002900 putative FPP binding hydrophobic cleft; other site 1097669002901 dimer interface [polypeptide binding]; other site 1097669002902 putative IPP diphosphate binding site; other site 1097669002903 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1097669002904 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 1097669002905 putative IPP diphosphate binding site; other site 1097669002906 PE family; Region: PE; pfam00934 1097669002908 Glycosyl hydrolase family 12; Region: Glyco_hydro_12; pfam01670 1097669002909 pantothenate kinase; Provisional; Region: PRK05439 1097669002910 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1097669002911 ATP-binding site [chemical binding]; other site 1097669002912 CoA-binding site [chemical binding]; other site 1097669002913 Mg2+-binding site [ion binding]; other site 1097669002914 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1097669002915 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1097669002916 dimer interface [polypeptide binding]; other site 1097669002917 active site 1097669002918 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1097669002919 folate binding site [chemical binding]; other site 1097669002920 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 1097669002921 dinuclear metal binding motif [ion binding]; other site 1097669002922 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 1097669002923 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 1097669002924 putative active site [active] 1097669002925 PhoH-like protein; Region: PhoH; pfam02562 1097669002926 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1097669002927 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1097669002928 NodB motif; other site 1097669002929 active site 1097669002930 catalytic site [active] 1097669002931 metal binding site [ion binding]; metal-binding site 1097669002932 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1097669002933 Class II fumarases; Region: Fumarase_classII; cd01362 1097669002934 active site 1097669002935 tetramer interface [polypeptide binding]; other site 1097669002936 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1097669002937 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1097669002938 putative active site [active] 1097669002939 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 1097669002940 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1097669002941 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1097669002942 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 1097669002943 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1097669002944 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1097669002945 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1097669002946 3beta-hydroxysteroid dehydrogenases (3b-HSD)-like, extended (e) SDRs; Region: 3b-HSD-like_SDR_e; cd05241 1097669002947 3-beta hydroxysteroid dehydrogenase/isomerase family; Region: 3Beta_HSD; pfam01073 1097669002948 putative NAD(P) binding site [chemical binding]; other site 1097669002949 active site 1097669002950 putative substrate binding site [chemical binding]; other site 1097669002951 exodeoxyribonuclease VII, small subunit; Region: xseB; TIGR01280 1097669002952 Exonuclease VII, large subunit [DNA replication, recombination, and repair]; Region: XseA; COG1570 1097669002953 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1097669002954 generic binding surface II; other site 1097669002955 generic binding surface I; other site 1097669002956 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1097669002957 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1097669002958 Yip1 domain; Region: Yip1; pfam04893 1097669002959 GTP-binding protein YchF; Reviewed; Region: PRK09601 1097669002960 YchF GTPase; Region: YchF; cd01900 1097669002961 G1 box; other site 1097669002962 GTP/Mg2+ binding site [chemical binding]; other site 1097669002963 Switch I region; other site 1097669002964 G2 box; other site 1097669002965 Switch II region; other site 1097669002966 G3 box; other site 1097669002967 G4 box; other site 1097669002968 G5 box; other site 1097669002969 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1097669002970 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 1097669002971 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: VapC; COG1487 1097669002972 putative active site [active] 1097669002973 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1097669002974 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1097669002975 cyclase homology domain; Region: CHD; cd07302 1097669002976 nucleotidyl binding site; other site 1097669002977 metal binding site [ion binding]; metal-binding site 1097669002978 dimer interface [polypeptide binding]; other site 1097669002979 glucose-6-phosphate 1-dehydrogenase; Region: zwf; TIGR00871 1097669002980 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1097669002981 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1097669002982 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1097669002983 6-phosphogluconate dehydrogenase (decarboxylating); Region: gnd_rel; TIGR00872 1097669002984 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1097669002985 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1097669002986 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1097669002987 pyruvate phosphate dikinase; Provisional; Region: PRK05878 1097669002988 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1097669002989 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700 1097669002990 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1097669002991 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1097669002992 active site 1097669002993 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1097669002994 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1097669002995 non-specific DNA binding site [nucleotide binding]; other site 1097669002996 salt bridge; other site 1097669002997 sequence-specific DNA binding site [nucleotide binding]; other site 1097669002998 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 1097669002999 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1097669003000 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 1097669003001 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 1097669003002 citrate synthase; Provisional; Region: PRK14033 1097669003003 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 1097669003004 oxalacetate binding site [chemical binding]; other site 1097669003005 citrylCoA binding site [chemical binding]; other site 1097669003006 coenzyme A binding site [chemical binding]; other site 1097669003007 catalytic triad [active] 1097669003008 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 1097669003009 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1097669003010 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1097669003011 THF binding site; other site 1097669003012 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1097669003013 substrate binding site [chemical binding]; other site 1097669003014 THF binding site; other site 1097669003015 zinc-binding site [ion binding]; other site 1097669003016 PPE family; Region: PPE; pfam00823 1097669003017 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1097669003018 active site 1097669003019 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1097669003020 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1097669003021 substrate binding site [chemical binding]; other site 1097669003022 oxyanion hole (OAH) forming residues; other site 1097669003023 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 1097669003024 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 1097669003025 CAAX protease self-immunity; Region: Abi; pfam02517 1097669003026 enoyl-CoA hydratase; Provisional; Region: PRK06688 1097669003027 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 1097669003028 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1097669003029 trimer interface [polypeptide binding]; other site 1097669003030 enoyl-CoA hydratase; Provisional; Region: PRK06688 1097669003031 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1097669003032 substrate binding site [chemical binding]; other site 1097669003033 oxyanion hole (OAH) forming residues; other site 1097669003034 trimer interface [polypeptide binding]; other site 1097669003035 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1097669003036 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1097669003037 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 1097669003038 NAD binding site [chemical binding]; other site 1097669003039 homodimer interface [polypeptide binding]; other site 1097669003040 homotetramer interface [polypeptide binding]; other site 1097669003041 active site 1097669003042 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1097669003043 MMPL family; Region: MMPL; pfam03176 1097669003044 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1097669003045 uncharacterized HhH-GPD family protein; Region: TIGR03252 1097669003046 minor groove reading motif; other site 1097669003047 helix-hairpin-helix signature motif; other site 1097669003048 mannosyltransferase; Provisional; Region: pimE; PRK13375 1097669003049 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 1097669003050 aromatic arch; other site 1097669003051 DCoH dimer interaction site [polypeptide binding]; other site 1097669003052 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 1097669003053 DCoH tetramer interaction site [polypeptide binding]; other site 1097669003054 substrate binding site [chemical binding]; other site 1097669003055 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1097669003056 active site 1097669003057 8-oxo-dGMP binding site [chemical binding]; other site 1097669003058 nudix motif; other site 1097669003059 metal binding site [ion binding]; metal-binding site 1097669003060 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 1097669003061 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1097669003062 [4Fe-4S] binding site [ion binding]; other site 1097669003063 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1097669003064 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1097669003065 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1097669003066 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1097669003067 molybdopterin cofactor binding site; other site 1097669003068 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1097669003069 nitrate reductase molybdenum cofactor assembly chaperone; Region: narJ; TIGR00684 1097669003070 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 1097669003071 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1097669003072 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1097669003073 G1 box; other site 1097669003074 putative GEF interaction site [polypeptide binding]; other site 1097669003075 GTP/Mg2+ binding site [chemical binding]; other site 1097669003076 Switch I region; other site 1097669003077 G2 box; other site 1097669003078 G3 box; other site 1097669003079 Switch II region; other site 1097669003080 G4 box; other site 1097669003081 G5 box; other site 1097669003082 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1097669003083 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1097669003084 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1097669003085 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 1097669003086 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1097669003087 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1097669003088 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1097669003089 PE family; Region: PE; pfam00934 1097669003090 N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D- glucopyranoside deacetylase; Region: mycothiol_MshB; TIGR03445 1097669003091 PE family; Region: PE; pfam00934 1097669003092 FO synthase; Reviewed; Region: fbiC; PRK09234 1097669003093 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1097669003094 FeS/SAM binding site; other site 1097669003095 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1097669003096 FeS/SAM binding site; other site 1097669003097 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1097669003098 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 1097669003099 active site 1097669003100 FMN binding site [chemical binding]; other site 1097669003101 2,4-decadienoyl-CoA binding site; other site 1097669003102 catalytic residue [active] 1097669003103 4Fe-4S cluster binding site [ion binding]; other site 1097669003104 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1097669003105 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1097669003106 Predicted transcriptional regulators [Transcription]; Region: COG1695 1097669003107 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1097669003108 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 1097669003109 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 1097669003110 4Fe-4S binding domain; Region: Fer4; pfam00037 1097669003111 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 1097669003112 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1097669003113 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1097669003114 homodimer interface [polypeptide binding]; other site 1097669003115 catalytic residue [active] 1097669003116 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1097669003117 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 1097669003118 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1097669003119 ATP binding site [chemical binding]; other site 1097669003120 putative Mg++ binding site [ion binding]; other site 1097669003121 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1097669003122 ATP-binding site [chemical binding]; other site 1097669003123 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1097669003124 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1097669003125 active site 1097669003126 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1097669003127 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1097669003128 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1097669003129 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1097669003130 Enoylreductase; Region: PKS_ER; smart00829 1097669003131 NAD(P) binding site [chemical binding]; other site 1097669003132 KR domain; Region: KR; pfam08659 1097669003133 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1097669003134 putative NADP binding site [chemical binding]; other site 1097669003135 active site 1097669003136 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1097669003137 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1097669003138 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1097669003139 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1097669003140 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1097669003141 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1097669003142 Enoylreductase; Region: PKS_ER; smart00829 1097669003143 NAD(P) binding site [chemical binding]; other site 1097669003144 KR domain; Region: KR; pfam08659 1097669003145 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1097669003146 putative NADP binding site [chemical binding]; other site 1097669003147 active site 1097669003148 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1097669003149 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1097669003150 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1097669003151 PE-PPE domain; Region: PE-PPE; pfam08237 1097669003152 acyl-CoA synthetase; Validated; Region: PRK05850 1097669003153 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1097669003154 acyl-activating enzyme (AAE) consensus motif; other site 1097669003155 active site 1097669003156 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1097669003157 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1097669003158 Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123 1097669003159 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 1097669003160 Glutamate binding site [chemical binding]; other site 1097669003161 NAD binding site [chemical binding]; other site 1097669003162 catalytic residues [active] 1097669003163 Proline dehydrogenase; Region: Pro_dh; pfam01619 1097669003164 RNA polymerase sigma factor SigI; Provisional; Region: sigI; PRK09635 1097669003165 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1097669003166 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1097669003167 DNA binding residues [nucleotide binding] 1097669003168 haloalkane dehalogenase; Provisional; Region: PRK03204 1097669003169 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1097669003170 catalytic site [active] 1097669003171 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1097669003172 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 1097669003173 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1097669003174 PGAP1-like protein; Region: PGAP1; pfam07819 1097669003175 acyl-CoA synthetase; Validated; Region: PRK07787 1097669003176 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1097669003177 acyl-activating enzyme (AAE) consensus motif; other site 1097669003178 AMP binding site [chemical binding]; other site 1097669003179 active site 1097669003180 CoA binding site [chemical binding]; other site 1097669003181 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1097669003182 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1097669003183 PE family; Region: PE; pfam00934 1097669003184 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1097669003185 PPE family; Region: PPE; pfam00823 1097669003186 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1097669003187 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1097669003188 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1097669003189 metabolite-proton symporter; Region: 2A0106; TIGR00883 1097669003190 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1097669003191 putative substrate translocation pore; other site 1097669003192 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 1097669003193 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 1097669003194 putative trimer interface [polypeptide binding]; other site 1097669003195 putative CoA binding site [chemical binding]; other site 1097669003196 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 1097669003197 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 1097669003198 metal binding site [ion binding]; metal-binding site 1097669003199 putative dimer interface [polypeptide binding]; other site 1097669003200 TIGR00730 family protein; Region: TIGR00730 1097669003201 long-chain-acyl-CoA synthetase; Validated; Region: PRK08279 1097669003202 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 1097669003203 acyl-activating enzyme (AAE) consensus motif; other site 1097669003204 putative AMP binding site [chemical binding]; other site 1097669003205 putative active site [active] 1097669003206 putative CoA binding site [chemical binding]; other site 1097669003207 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1097669003208 dihydropteroate synthase; Region: DHPS; TIGR01496 1097669003209 substrate binding pocket [chemical binding]; other site 1097669003210 dimer interface [polypeptide binding]; other site 1097669003211 inhibitor binding site; inhibition site 1097669003212 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 1097669003213 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1097669003214 DivIVA domain; Region: DivI1A_domain; TIGR03544 1097669003215 DNA-3-methyladenine glycosylase I; Region: tag; TIGR00624 1097669003216 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 1097669003217 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 1097669003218 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1097669003219 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 1097669003220 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1097669003221 ligand binding site; other site 1097669003222 oligomer interface; other site 1097669003223 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1097669003224 dimer interface [polypeptide binding]; other site 1097669003225 N-terminal domain interface [polypeptide binding]; other site 1097669003226 sulfate 1 binding site; other site 1097669003227 PE family; Region: PE; pfam00934 1097669003228 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 1097669003229 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 1097669003230 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1097669003231 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 1097669003232 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1097669003233 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1097669003234 Walker A/P-loop; other site 1097669003235 ATP binding site [chemical binding]; other site 1097669003236 Q-loop/lid; other site 1097669003237 ABC transporter signature motif; other site 1097669003238 Walker B; other site 1097669003239 D-loop; other site 1097669003240 H-loop/switch region; other site 1097669003241 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1097669003242 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1097669003243 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1097669003244 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1097669003245 S-adenosylmethionine binding site [chemical binding]; other site 1097669003246 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647 1097669003247 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1097669003248 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1097669003249 DNA binding residues [nucleotide binding] 1097669003250 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1097669003251 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1097669003252 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1097669003253 protein binding site [polypeptide binding]; other site 1097669003254 sec-independent translocase; Provisional; Region: PRK03100 1097669003255 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1097669003256 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1097669003257 active site 1097669003258 motif I; other site 1097669003259 motif II; other site 1097669003260 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1097669003261 Predicted membrane protein [Function unknown]; Region: COG3428 1097669003262 Bacterial PH domain; Region: DUF304; pfam03703 1097669003263 Uncharacterized conserved protein [Function unknown]; Region: COG3402 1097669003264 Domain of unknown function DUF59; Region: DUF59; cl00941 1097669003265 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1097669003266 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1097669003267 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 1097669003268 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1097669003269 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1097669003270 catalytic residue [active] 1097669003271 Predicted membrane protein [Function unknown]; Region: COG4420 1097669003272 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1097669003273 MgtE intracellular N domain; Region: MgtE_N; smart00924 1097669003274 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1097669003275 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 1097669003276 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1097669003277 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1097669003278 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1097669003279 dimer interface [polypeptide binding]; other site 1097669003280 conserved gate region; other site 1097669003281 putative PBP binding loops; other site 1097669003282 ABC-ATPase subunit interface; other site 1097669003283 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1097669003284 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1097669003285 dimer interface [polypeptide binding]; other site 1097669003286 conserved gate region; other site 1097669003287 ABC-ATPase subunit interface; other site 1097669003288 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1097669003289 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1097669003290 Walker A/P-loop; other site 1097669003291 ATP binding site [chemical binding]; other site 1097669003292 Q-loop/lid; other site 1097669003293 ABC transporter signature motif; other site 1097669003294 Walker B; other site 1097669003295 D-loop; other site 1097669003296 H-loop/switch region; other site 1097669003297 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1097669003298 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 1097669003299 oligomer interface [polypeptide binding]; other site 1097669003300 metal binding site [ion binding]; metal-binding site 1097669003301 metal binding site [ion binding]; metal-binding site 1097669003302 putative Cl binding site [ion binding]; other site 1097669003303 basic sphincter; other site 1097669003304 hydrophobic gate; other site 1097669003305 periplasmic entrance; other site 1097669003306 malate dehydrogenase; Provisional; Region: PRK05442 1097669003307 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 1097669003308 NAD(P) binding site [chemical binding]; other site 1097669003309 dimer interface [polypeptide binding]; other site 1097669003310 malate binding site [chemical binding]; other site 1097669003311 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 1097669003312 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1097669003313 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1097669003314 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1097669003315 NAD(P) binding site [chemical binding]; other site 1097669003316 active site 1097669003317 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 1097669003318 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 1097669003319 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 1097669003320 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1097669003321 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1097669003322 TPP-binding site [chemical binding]; other site 1097669003323 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1097669003324 dimer interface [polypeptide binding]; other site 1097669003325 PYR/PP interface [polypeptide binding]; other site 1097669003326 TPP binding site [chemical binding]; other site 1097669003327 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1097669003328 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1097669003329 putative substrate translocation pore; other site 1097669003330 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1097669003331 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 1097669003332 RNase_H superfamily; Region: RNase_H_2; pfam13482 1097669003333 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 1097669003334 Part of AAA domain; Region: AAA_19; pfam13245 1097669003335 AAA domain; Region: AAA_12; pfam13087 1097669003336 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 1097669003337 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1097669003338 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1097669003339 ATP binding site [chemical binding]; other site 1097669003340 Mg++ binding site [ion binding]; other site 1097669003341 motif III; other site 1097669003342 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1097669003343 nucleotide binding region [chemical binding]; other site 1097669003344 ATP-binding site [chemical binding]; other site 1097669003345 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 1097669003346 putative RNA binding site [nucleotide binding]; other site 1097669003347 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1097669003348 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1097669003349 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1097669003350 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1097669003351 FAD binding domain; Region: FAD_binding_4; pfam01565 1097669003352 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 1097669003353 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1097669003354 H+ Antiporter protein; Region: 2A0121; TIGR00900 1097669003355 putative substrate translocation pore; other site 1097669003356 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 1097669003357 Fe-S cluster binding site [ion binding]; other site 1097669003358 DNA binding site [nucleotide binding] 1097669003359 active site 1097669003360 hypothetical protein; Validated; Region: PRK05868 1097669003361 hypothetical protein; Provisional; Region: PRK07236 1097669003362 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1097669003363 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1097669003364 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1097669003365 HIT family signature motif; other site 1097669003366 catalytic residue [active] 1097669003367 amidase; Provisional; Region: PRK12470 1097669003368 Amidase; Region: Amidase; pfam01425 1097669003369 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1097669003370 cyclase homology domain; Region: CHD; cd07302 1097669003371 nucleotidyl binding site; other site 1097669003372 metal binding site [ion binding]; metal-binding site 1097669003373 dimer interface [polypeptide binding]; other site 1097669003374 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1097669003375 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1097669003376 active site 1097669003377 ATP binding site [chemical binding]; other site 1097669003378 substrate binding site [chemical binding]; other site 1097669003379 activation loop (A-loop); other site 1097669003380 PknH-like extracellular domain; Region: PknH_C; pfam14032 1097669003381 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 1097669003382 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 1097669003383 DNA binding site [nucleotide binding] 1097669003384 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1097669003385 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1097669003386 phosphopeptide binding site; other site 1097669003387 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 1097669003388 putative active site [active] 1097669003389 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 1097669003390 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 1097669003391 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1097669003392 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1097669003393 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1097669003394 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1097669003395 Walker A/P-loop; other site 1097669003396 ATP binding site [chemical binding]; other site 1097669003397 Q-loop/lid; other site 1097669003398 ABC transporter signature motif; other site 1097669003399 Walker B; other site 1097669003400 D-loop; other site 1097669003401 H-loop/switch region; other site 1097669003402 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1097669003403 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1097669003404 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1097669003405 Walker A/P-loop; other site 1097669003406 ATP binding site [chemical binding]; other site 1097669003407 Q-loop/lid; other site 1097669003408 ABC transporter signature motif; other site 1097669003409 Walker B; other site 1097669003410 D-loop; other site 1097669003411 H-loop/switch region; other site 1097669003412 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 1097669003413 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 1097669003414 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1097669003415 catalytic core [active] 1097669003416 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1097669003417 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1097669003418 active site 1097669003419 metal binding site [ion binding]; metal-binding site 1097669003420 DNA binding site [nucleotide binding] 1097669003421 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1097669003422 Walker A/P-loop; other site 1097669003423 ATP binding site [chemical binding]; other site 1097669003424 choline dehydrogenase; Validated; Region: PRK02106 1097669003425 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1097669003426 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1097669003427 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1097669003428 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 1097669003429 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 1097669003430 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1097669003431 Walker A/P-loop; other site 1097669003432 ATP binding site [chemical binding]; other site 1097669003433 Q-loop/lid; other site 1097669003434 ABC transporter signature motif; other site 1097669003435 Walker B; other site 1097669003436 D-loop; other site 1097669003437 H-loop/switch region; other site 1097669003438 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1097669003439 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1097669003440 Walker A/P-loop; other site 1097669003441 ATP binding site [chemical binding]; other site 1097669003442 Q-loop/lid; other site 1097669003443 ABC transporter signature motif; other site 1097669003444 Walker B; other site 1097669003445 D-loop; other site 1097669003446 H-loop/switch region; other site 1097669003447 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1097669003448 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1097669003449 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1097669003450 dimer interface [polypeptide binding]; other site 1097669003451 conserved gate region; other site 1097669003452 putative PBP binding loops; other site 1097669003453 ABC-ATPase subunit interface; other site 1097669003454 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 1097669003455 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1097669003456 dimer interface [polypeptide binding]; other site 1097669003457 conserved gate region; other site 1097669003458 putative PBP binding loops; other site 1097669003459 ABC-ATPase subunit interface; other site 1097669003460 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 1097669003461 active site clefts [active] 1097669003462 zinc binding site [ion binding]; other site 1097669003463 dimer interface [polypeptide binding]; other site 1097669003464 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1097669003465 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1097669003466 Active Sites [active] 1097669003467 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 1097669003468 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1097669003469 CysD dimerization site [polypeptide binding]; other site 1097669003470 G1 box; other site 1097669003471 putative GEF interaction site [polypeptide binding]; other site 1097669003472 GTP/Mg2+ binding site [chemical binding]; other site 1097669003473 Switch I region; other site 1097669003474 G2 box; other site 1097669003475 G3 box; other site 1097669003476 Switch II region; other site 1097669003477 G4 box; other site 1097669003478 G5 box; other site 1097669003479 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1097669003480 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 1097669003481 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1097669003482 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1097669003483 Walker A/P-loop; other site 1097669003484 ligand-binding site [chemical binding]; other site 1097669003485 ATP binding site [chemical binding]; other site 1097669003486 Rrf2 family protein; Region: rrf2_super; TIGR00738 1097669003487 Transcriptional regulator; Region: Rrf2; pfam02082 1097669003488 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1097669003489 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1097669003490 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1097669003491 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1097669003492 Putative esterase; Region: Esterase; pfam00756 1097669003493 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1097669003494 Predicted membrane protein [Function unknown]; Region: COG4325 1097669003495 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 1097669003496 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1097669003497 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 1097669003498 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1097669003499 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1097669003500 active site 1097669003501 HIGH motif; other site 1097669003502 KMSK motif region; other site 1097669003503 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1097669003504 tRNA binding surface [nucleotide binding]; other site 1097669003505 anticodon binding site; other site 1097669003506 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1097669003507 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1097669003508 active site 1097669003509 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1097669003510 substrate binding site [chemical binding]; other site 1097669003511 catalytic residues [active] 1097669003512 dimer interface [polypeptide binding]; other site 1097669003513 homoserine dehydrogenase; Provisional; Region: PRK06349 1097669003514 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1097669003515 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1097669003516 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1097669003517 threonine synthase; Reviewed; Region: PRK06721 1097669003518 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1097669003519 homodimer interface [polypeptide binding]; other site 1097669003520 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1097669003521 catalytic residue [active] 1097669003522 Homoserine kinase [Amino acid transport and metabolism]; Region: ThrB; COG0083 1097669003523 transcription termination factor Rho; Provisional; Region: PRK12678 1097669003524 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1097669003525 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1097669003526 RNA binding site [nucleotide binding]; other site 1097669003527 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1097669003528 multimer interface [polypeptide binding]; other site 1097669003529 Walker A motif; other site 1097669003530 ATP binding site [chemical binding]; other site 1097669003531 Walker B motif; other site 1097669003532 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1097669003533 peptide chain release factor 1; Region: prfA; TIGR00019 1097669003534 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1097669003535 RF-1 domain; Region: RF-1; pfam00472 1097669003536 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1097669003537 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1097669003538 S-adenosylmethionine binding site [chemical binding]; other site 1097669003539 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1097669003540 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1097669003541 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1097669003542 Mg++ binding site [ion binding]; other site 1097669003543 putative catalytic motif [active] 1097669003544 substrate binding site [chemical binding]; other site 1097669003545 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1097669003546 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1097669003547 F0F1 ATP synthase subunit C; Validated; Region: PRK05880 1097669003548 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1097669003549 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1097669003550 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13428 1097669003551 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1097669003552 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 1097669003553 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1097669003554 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1097669003555 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1097669003556 Walker A motif; other site 1097669003557 ATP binding site [chemical binding]; other site 1097669003558 Walker B motif; other site 1097669003559 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1097669003560 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1097669003561 core domain interface [polypeptide binding]; other site 1097669003562 delta subunit interface [polypeptide binding]; other site 1097669003563 epsilon subunit interface [polypeptide binding]; other site 1097669003564 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1097669003565 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1097669003566 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1097669003567 alpha subunit interaction interface [polypeptide binding]; other site 1097669003568 Walker A motif; other site 1097669003569 ATP binding site [chemical binding]; other site 1097669003570 Walker B motif; other site 1097669003571 inhibitor binding site; inhibition site 1097669003572 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1097669003573 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1097669003574 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1097669003575 gamma subunit interface [polypeptide binding]; other site 1097669003576 epsilon subunit interface [polypeptide binding]; other site 1097669003577 LBP interface [polypeptide binding]; other site 1097669003578 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 1097669003579 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 1097669003580 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1097669003581 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1097669003582 hinge; other site 1097669003583 active site 1097669003584 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 1097669003585 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1097669003586 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1097669003587 DNA binding site [nucleotide binding] 1097669003588 active site 1097669003589 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 1097669003590 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1097669003591 AlkA N-terminal domain; Region: AlkA_N; pfam06029 1097669003592 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 1097669003593 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1097669003594 minor groove reading motif; other site 1097669003595 helix-hairpin-helix signature motif; other site 1097669003596 substrate binding pocket [chemical binding]; other site 1097669003597 active site 1097669003598 HAMP domain; Region: HAMP; pfam00672 1097669003599 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1097669003600 cyclase homology domain; Region: CHD; cd07302 1097669003601 nucleotidyl binding site; other site 1097669003602 metal binding site [ion binding]; metal-binding site 1097669003603 dimer interface [polypeptide binding]; other site 1097669003604 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1097669003605 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1097669003606 dimerization interface [polypeptide binding]; other site 1097669003607 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1097669003608 cyclase homology domain; Region: CHD; cd07302 1097669003609 nucleotidyl binding site; other site 1097669003610 metal binding site [ion binding]; metal-binding site 1097669003611 dimer interface [polypeptide binding]; other site 1097669003612 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 1097669003613 hypothetical protein; Provisional; Region: PRK03298 1097669003614 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1097669003615 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 1097669003616 dimer interface [polypeptide binding]; other site 1097669003617 substrate binding site [chemical binding]; other site 1097669003618 metal binding site [ion binding]; metal-binding site 1097669003619 putative acyltransferase; Provisional; Region: PRK05790 1097669003620 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1097669003621 dimer interface [polypeptide binding]; other site 1097669003622 active site 1097669003623 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 1097669003624 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 1097669003625 glycogen branching enzyme; Provisional; Region: PRK05402 1097669003626 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1097669003627 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1097669003628 active site 1097669003629 catalytic site [active] 1097669003630 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1097669003631 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 1097669003632 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 1097669003633 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1097669003634 active site 1097669003635 homodimer interface [polypeptide binding]; other site 1097669003636 catalytic site [active] 1097669003637 acceptor binding site [chemical binding]; other site 1097669003638 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 1097669003639 putative homodimer interface [polypeptide binding]; other site 1097669003640 putative active site pocket [active] 1097669003641 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 1097669003642 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 1097669003643 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 1097669003644 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 1097669003645 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 1097669003646 putative active site pocket [active] 1097669003647 cleavage site 1097669003648 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 1097669003649 MPN+ (JAMM) motif; other site 1097669003650 Zinc-binding site [ion binding]; other site 1097669003651 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1097669003652 MoaE interaction surface [polypeptide binding]; other site 1097669003653 MoeB interaction surface [polypeptide binding]; other site 1097669003654 thiocarboxylated glycine; other site 1097669003655 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1097669003656 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1097669003657 dimer interface [polypeptide binding]; other site 1097669003658 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1097669003659 catalytic residue [active] 1097669003660 Rhomboid family; Region: Rhomboid; pfam01694 1097669003661 glutamate racemase; Provisional; Region: PRK00865 1097669003662 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1097669003663 ribonuclease PH; Reviewed; Region: rph; PRK00173 1097669003664 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1097669003665 hexamer interface [polypeptide binding]; other site 1097669003666 active site 1097669003667 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1097669003668 active site 1097669003669 dimerization interface [polypeptide binding]; other site 1097669003670 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 1097669003671 Glucitol operon activator [Transcription]; Region: GutM; COG4578 1097669003672 acyl carrier protein; Validated; Region: PRK05883 1097669003673 long-chain-fatty-acid--[acyl-carrier-protein] ligase; Validated; Region: PRK05851 1097669003674 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1097669003675 acyl-activating enzyme (AAE) consensus motif; other site 1097669003676 active site 1097669003677 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1097669003678 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1097669003679 active site 1097669003680 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1097669003681 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 1097669003682 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1097669003683 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1097669003684 FAD binding pocket [chemical binding]; other site 1097669003685 FAD binding motif [chemical binding]; other site 1097669003686 phosphate binding motif [ion binding]; other site 1097669003687 NAD binding pocket [chemical binding]; other site 1097669003688 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1097669003689 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1097669003690 Walker A/P-loop; other site 1097669003691 ATP binding site [chemical binding]; other site 1097669003692 Q-loop/lid; other site 1097669003693 ABC transporter signature motif; other site 1097669003694 Walker B; other site 1097669003695 D-loop; other site 1097669003696 H-loop/switch region; other site 1097669003697 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1097669003698 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1097669003699 Walker A/P-loop; other site 1097669003700 ATP binding site [chemical binding]; other site 1097669003701 Q-loop/lid; other site 1097669003702 ABC transporter signature motif; other site 1097669003703 Walker B; other site 1097669003704 D-loop; other site 1097669003705 H-loop/switch region; other site 1097669003706 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1097669003707 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1097669003708 NAD(P) binding site [chemical binding]; other site 1097669003709 active site 1097669003710 tetracycline repressor protein TetR; Provisional; Region: PRK13756 1097669003711 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1097669003712 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1097669003713 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1097669003714 GAF domain; Region: GAF; pfam01590 1097669003715 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1097669003716 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1097669003717 metal binding site [ion binding]; metal-binding site 1097669003718 active site 1097669003719 I-site; other site 1097669003720 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1097669003721 hypothetical protein; Provisional; Region: PRK07877 1097669003722 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 1097669003723 ATP binding site [chemical binding]; other site 1097669003724 substrate interface [chemical binding]; other site 1097669003725 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1097669003726 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1097669003727 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1097669003728 cyclase homology domain; Region: CHD; cd07302 1097669003729 nucleotidyl binding site; other site 1097669003730 dimer interface [polypeptide binding]; other site 1097669003731 metal binding site [ion binding]; metal-binding site 1097669003732 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1097669003733 cyclase homology domain; Region: CHD; cd07302 1097669003734 probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841 1097669003735 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1097669003736 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1097669003737 PPE family; Region: PPE; pfam00823 1097669003738 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1097669003739 PAS fold; Region: PAS_4; pfam08448 1097669003740 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1097669003741 putative active site [active] 1097669003742 heme pocket [chemical binding]; other site 1097669003743 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1097669003744 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1097669003745 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1097669003746 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1097669003747 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1097669003748 anti sigma factor interaction site; other site 1097669003749 regulatory phosphorylation site [posttranslational modification]; other site 1097669003750 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1097669003751 anti sigma factor interaction site; other site 1097669003752 regulatory phosphorylation site [posttranslational modification]; other site 1097669003753 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1097669003754 synthetase active site [active] 1097669003755 NTP binding site [chemical binding]; other site 1097669003756 metal binding site [ion binding]; metal-binding site 1097669003757 Beta-lactamase; Region: Beta-lactamase; pfam00144 1097669003758 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1097669003759 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 1097669003760 Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; pfam00173 1097669003761 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1097669003762 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 1097669003763 putative di-iron ligands [ion binding]; other site 1097669003764 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 1097669003765 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 1097669003766 malonyl-CoA binding site [chemical binding]; other site 1097669003767 dimer interface [polypeptide binding]; other site 1097669003768 active site 1097669003769 product binding site; other site 1097669003770 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 1097669003771 uncharacterized domain; Region: TIGR00702 1097669003772 YcaO-like family; Region: YcaO; pfam02624 1097669003773 Uncharacterized conserved protein [Function unknown]; Region: COG3482 1097669003774 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1097669003775 S-adenosylmethionine binding site [chemical binding]; other site 1097669003776 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1097669003777 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1097669003778 active site 1097669003779 bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; Provisional; Region: PRK05205 1097669003780 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1097669003781 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1097669003782 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1097669003783 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1097669003784 dihydroorotase; Validated; Region: pyrC; PRK09357 1097669003785 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1097669003786 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1097669003787 active site 1097669003788 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1097669003789 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1097669003790 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1097669003791 catalytic site [active] 1097669003792 subunit interface [polypeptide binding]; other site 1097669003793 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1097669003794 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1097669003795 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1097669003796 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1097669003797 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1097669003798 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1097669003799 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1097669003800 IMP binding site; other site 1097669003801 dimer interface [polypeptide binding]; other site 1097669003802 interdomain contacts; other site 1097669003803 partial ornithine binding site; other site 1097669003804 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1097669003805 active site 1097669003806 dimer interface [polypeptide binding]; other site 1097669003807 PE family; Region: PE; pfam00934 1097669003808 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1097669003809 PPE family; Region: PPE; pfam00823 1097669003810 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1097669003811 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1097669003812 catalytic site [active] 1097669003813 G-X2-G-X-G-K; other site 1097669003814 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 1097669003815 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1097669003816 Flavoprotein; Region: Flavoprotein; pfam02441 1097669003817 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1097669003818 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1097669003819 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1097669003820 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1097669003821 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1097669003822 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1097669003823 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1097669003824 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1097669003825 Cytochrome P450; Region: p450; cl12078 1097669003826 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1097669003827 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1097669003828 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1097669003829 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1097669003830 oligomeric interface; other site 1097669003831 putative active site [active] 1097669003832 homodimer interface [polypeptide binding]; other site 1097669003833 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1097669003834 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1097669003835 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1097669003836 substrate binding pocket [chemical binding]; other site 1097669003837 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1097669003838 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1097669003839 substrate binding pocket [chemical binding]; other site 1097669003840 Predicted membrane protein [Function unknown]; Region: COG3714 1097669003841 primosome assembly protein PriA; Provisional; Region: PRK14873 1097669003842 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1097669003843 S-adenosylmethionine binding site [chemical binding]; other site 1097669003844 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1097669003845 MarR family; Region: MarR; pfam01047 1097669003846 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1097669003847 S-adenosylmethionine binding site [chemical binding]; other site 1097669003848 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1097669003849 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1097669003850 putative active site [active] 1097669003851 substrate binding site [chemical binding]; other site 1097669003852 putative cosubstrate binding site; other site 1097669003853 catalytic site [active] 1097669003854 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1097669003855 substrate binding site [chemical binding]; other site 1097669003856 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 1097669003857 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 1097669003858 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 1097669003859 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1097669003860 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 1097669003861 substrate binding site [chemical binding]; other site 1097669003862 hexamer interface [polypeptide binding]; other site 1097669003863 metal binding site [ion binding]; metal-binding site 1097669003864 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1097669003865 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1097669003866 catalytic motif [active] 1097669003867 Zn binding site [ion binding]; other site 1097669003868 RibD C-terminal domain; Region: RibD_C; pfam01872 1097669003869 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1097669003870 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1097669003871 putative substrate translocation pore; other site 1097669003872 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 1097669003873 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1097669003874 Lumazine binding domain; Region: Lum_binding; pfam00677 1097669003875 Lumazine binding domain; Region: Lum_binding; pfam00677 1097669003876 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 1097669003877 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1097669003878 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1097669003879 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 1097669003880 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1097669003881 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1097669003882 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1097669003883 dimerization interface [polypeptide binding]; other site 1097669003884 active site 1097669003885 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1097669003886 homopentamer interface [polypeptide binding]; other site 1097669003887 active site 1097669003888 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1097669003889 PknH-like extracellular domain; Region: PknH_C; pfam14032 1097669003890 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1097669003891 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1097669003892 putative sugar binding sites [chemical binding]; other site 1097669003893 Q-X-W motif; other site 1097669003894 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1097669003895 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1097669003896 GIY-YIG motif/motif A; other site 1097669003897 active site 1097669003898 catalytic site [active] 1097669003899 putative DNA binding site [nucleotide binding]; other site 1097669003900 metal binding site [ion binding]; metal-binding site 1097669003901 UvrB/uvrC motif; Region: UVR; pfam02151 1097669003902 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1097669003903 Helix-hairpin-helix motif; Region: HHH; pfam00633 1097669003904 P-loop ATPase protein family; Region: ATP_bind_2; pfam03668 1097669003905 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1097669003906 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1097669003907 phosphate binding site [ion binding]; other site 1097669003908 putative substrate binding pocket [chemical binding]; other site 1097669003909 dimer interface [polypeptide binding]; other site 1097669003910 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1097669003911 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1097669003912 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1097669003913 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1097669003914 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1097669003915 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1097669003916 acyl-CoA synthetase; Provisional; Region: PRK13382 1097669003917 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1097669003918 acyl-activating enzyme (AAE) consensus motif; other site 1097669003919 putative AMP binding site [chemical binding]; other site 1097669003920 putative active site [active] 1097669003921 putative CoA binding site [chemical binding]; other site 1097669003922 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1097669003923 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 1097669003924 putative acyl-acceptor binding pocket; other site 1097669003925 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1097669003926 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1097669003927 PE family; Region: PE; pfam00934 1097669003928 PE-PPE domain; Region: PE-PPE; pfam08237 1097669003929 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 1097669003930 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1097669003931 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1097669003932 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 1097669003933 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1097669003934 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1097669003935 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1097669003936 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1097669003937 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1097669003938 Phosphoglycerate kinase; Region: PGK; pfam00162 1097669003939 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1097669003940 substrate binding site [chemical binding]; other site 1097669003941 hinge regions; other site 1097669003942 ADP binding site [chemical binding]; other site 1097669003943 catalytic site [active] 1097669003944 triosephosphate isomerase; Provisional; Region: PRK14567 1097669003945 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1097669003946 substrate binding site [chemical binding]; other site 1097669003947 dimer interface [polypeptide binding]; other site 1097669003948 catalytic triad [active] 1097669003949 SnoaL-like domain; Region: SnoaL_2; pfam12680 1097669003950 Preprotein translocase SecG subunit; Region: SecG; cl09123 1097669003951 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 1097669003952 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 1097669003953 molybdopterin cofactor binding site [chemical binding]; other site 1097669003954 substrate binding site [chemical binding]; other site 1097669003955 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 1097669003956 molybdopterin cofactor binding site; other site 1097669003957 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1097669003958 hydrophobic ligand binding site; other site 1097669003959 Proteins of 100 residues with WXG; Region: WXG100; cl02005 1097669003960 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1097669003961 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 1097669003962 putative active site [active] 1097669003963 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1097669003964 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1097669003965 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1097669003966 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 1097669003967 putative active site [active] 1097669003968 transaldolase; Provisional; Region: PRK03903 1097669003969 catalytic residue [active] 1097669003970 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1097669003971 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1097669003972 TPP-binding site [chemical binding]; other site 1097669003973 dimer interface [polypeptide binding]; other site 1097669003974 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1097669003975 PYR/PP interface [polypeptide binding]; other site 1097669003976 dimer interface [polypeptide binding]; other site 1097669003977 TPP binding site [chemical binding]; other site 1097669003978 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1097669003979 UbiA prenyltransferase family; Region: UbiA; pfam01040 1097669003980 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1097669003981 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1097669003982 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 1097669003983 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 1097669003984 NADP binding site [chemical binding]; other site 1097669003985 dimer interface [polypeptide binding]; other site 1097669003986 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1097669003987 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1097669003988 ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025 1097669003989 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1097669003990 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1097669003991 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1097669003992 Walker A/P-loop; other site 1097669003993 ATP binding site [chemical binding]; other site 1097669003994 Q-loop/lid; other site 1097669003995 ABC transporter signature motif; other site 1097669003996 Walker B; other site 1097669003997 D-loop; other site 1097669003998 H-loop/switch region; other site 1097669003999 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 1097669004000 Predicted transcriptional regulator [Transcription]; Region: COG2345 1097669004001 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1097669004002 putative DNA binding site [nucleotide binding]; other site 1097669004003 putative Zn2+ binding site [ion binding]; other site 1097669004004 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1097669004005 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1097669004006 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1097669004007 protein-splicing catalytic site; other site 1097669004008 thioester formation/cholesterol transfer; other site 1097669004009 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 1097669004010 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 1097669004011 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1097669004012 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1097669004013 FeS assembly protein SufD; Region: sufD; TIGR01981 1097669004014 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1097669004015 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1097669004016 Walker A/P-loop; other site 1097669004017 ATP binding site [chemical binding]; other site 1097669004018 Q-loop/lid; other site 1097669004019 ABC transporter signature motif; other site 1097669004020 Walker B; other site 1097669004021 D-loop; other site 1097669004022 H-loop/switch region; other site 1097669004023 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1097669004024 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1097669004025 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1097669004026 catalytic residue [active] 1097669004027 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1097669004028 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1097669004029 trimerization site [polypeptide binding]; other site 1097669004030 active site 1097669004031 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1097669004032 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1097669004033 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1097669004034 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1097669004035 active site 1097669004036 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1097669004037 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 1097669004038 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1097669004039 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1097669004040 catalytic residues [active] 1097669004041 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1097669004042 catalytic residues [active] 1097669004043 enoyl-CoA hydratase; Provisional; Region: PRK05864 1097669004044 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1097669004045 substrate binding site [chemical binding]; other site 1097669004046 oxyanion hole (OAH) forming residues; other site 1097669004047 trimer interface [polypeptide binding]; other site 1097669004048 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1097669004049 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1097669004050 Walker A/P-loop; other site 1097669004051 ATP binding site [chemical binding]; other site 1097669004052 Q-loop/lid; other site 1097669004053 ABC transporter signature motif; other site 1097669004054 Walker B; other site 1097669004055 D-loop; other site 1097669004056 H-loop/switch region; other site 1097669004057 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1097669004058 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1097669004059 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1097669004060 aconitate hydratase; Validated; Region: PRK09277 1097669004061 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1097669004062 substrate binding site [chemical binding]; other site 1097669004063 ligand binding site [chemical binding]; other site 1097669004064 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1097669004065 substrate binding site [chemical binding]; other site 1097669004066 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1097669004067 NlpC/P60 family; Region: NLPC_P60; pfam00877 1097669004068 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1097669004069 NlpC/P60 family; Region: NLPC_P60; pfam00877 1097669004070 MoxR-like ATPases [General function prediction only]; Region: COG0714 1097669004071 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1097669004072 Walker A motif; other site 1097669004073 ATP binding site [chemical binding]; other site 1097669004074 Walker B motif; other site 1097669004075 arginine finger; other site 1097669004076 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1097669004077 Protein of unknown function DUF58; Region: DUF58; pfam01882 1097669004078 hypothetical protein; Provisional; Region: PRK13685 1097669004079 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1097669004080 metal ion-dependent adhesion site (MIDAS); other site 1097669004081 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1097669004082 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1097669004083 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1097669004084 NAD(P) binding site [chemical binding]; other site 1097669004085 homotetramer interface [polypeptide binding]; other site 1097669004086 homodimer interface [polypeptide binding]; other site 1097669004087 active site 1097669004088 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 1097669004089 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1097669004090 NAD binding site [chemical binding]; other site 1097669004091 homotetramer interface [polypeptide binding]; other site 1097669004092 homodimer interface [polypeptide binding]; other site 1097669004093 substrate binding site [chemical binding]; other site 1097669004094 active site 1097669004095 ferrochelatase; Reviewed; Region: hemH; PRK00035 1097669004096 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1097669004097 C-terminal domain interface [polypeptide binding]; other site 1097669004098 active site 1097669004099 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1097669004100 active site 1097669004101 N-terminal domain interface [polypeptide binding]; other site 1097669004102 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 1097669004103 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1097669004104 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1097669004105 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 1097669004106 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1097669004107 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1097669004108 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 1097669004109 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 1097669004110 heterodimer interface [polypeptide binding]; other site 1097669004111 substrate interaction site [chemical binding]; other site 1097669004112 Methylmalonyl-CoA mutase, C-terminal domain/subunit (cobalamin-binding) [Lipid metabolism]; Region: Sbm; COG2185 1097669004113 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 1097669004114 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 1097669004115 active site 1097669004116 substrate binding site [chemical binding]; other site 1097669004117 coenzyme B12 binding site [chemical binding]; other site 1097669004118 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 1097669004119 B12 binding site [chemical binding]; other site 1097669004120 cobalt ligand [ion binding]; other site 1097669004121 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 1097669004122 membrane ATPase/protein kinase; Provisional; Region: PRK09435 1097669004123 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 1097669004124 Walker A; other site 1097669004125 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1097669004126 Beta-lactamase; Region: Beta-lactamase; pfam00144 1097669004127 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1097669004128 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1097669004129 S-adenosylmethionine binding site [chemical binding]; other site 1097669004130 Uncharacterized conserved protein [Function unknown]; Region: COG3360 1097669004131 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1097669004132 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1097669004133 Ligand binding site; other site 1097669004134 Putative Catalytic site; other site 1097669004135 DXD motif; other site 1097669004136 Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5285 1097669004137 Glycosyl hydrolase families 32 and 68, which for the clan GH-J; Region: GH_J; cd08979 1097669004138 active site 1097669004140 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1097669004141 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1097669004142 inhibitor-cofactor binding pocket; inhibition site 1097669004143 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1097669004144 catalytic residue [active] 1097669004145 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 1097669004146 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 1097669004147 putative trimer interface [polypeptide binding]; other site 1097669004148 putative CoA binding site [chemical binding]; other site 1097669004149 Methyltransferase domain; Region: Methyltransf_12; pfam08242 1097669004150 S-adenosylmethionine binding site [chemical binding]; other site 1097669004151 WbqC-like protein family; Region: WbqC; pfam08889 1097669004152 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 1097669004153 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1097669004154 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1097669004155 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1097669004156 Methyltransferase domain; Region: Methyltransf_12; pfam08242 1097669004157 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 1097669004158 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 1097669004159 NADP-binding site; other site 1097669004160 homotetramer interface [polypeptide binding]; other site 1097669004161 substrate binding site [chemical binding]; other site 1097669004162 homodimer interface [polypeptide binding]; other site 1097669004163 active site 1097669004164 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 1097669004165 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 1097669004166 NADP binding site [chemical binding]; other site 1097669004167 active site 1097669004168 putative substrate binding site [chemical binding]; other site 1097669004169 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 1097669004170 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 1097669004171 metal-binding site 1097669004172 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1097669004173 S-adenosylmethionine binding site [chemical binding]; other site 1097669004174 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1097669004175 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1097669004176 active site 1097669004177 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 1097669004178 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1097669004179 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1097669004180 active site 1097669004181 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1097669004182 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1097669004183 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1097669004184 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1097669004185 active site 1097669004186 acyl-CoA synthetase; Validated; Region: PRK05850 1097669004187 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1097669004188 acyl-activating enzyme (AAE) consensus motif; other site 1097669004189 active site 1097669004190 Transport protein; Region: actII; TIGR00833 1097669004191 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1097669004192 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1097669004193 S-adenosylmethionine binding site [chemical binding]; other site 1097669004194 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1097669004195 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1097669004196 homodimer interface [polypeptide binding]; other site 1097669004197 active site 1097669004198 TDP-binding site; other site 1097669004199 acceptor substrate-binding pocket; other site 1097669004200 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1097669004201 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1097669004202 Probable Catalytic site; other site 1097669004203 metal-binding site 1097669004204 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1097669004205 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1097669004206 homodimer interface [polypeptide binding]; other site 1097669004207 active site 1097669004208 TDP-binding site; other site 1097669004209 acceptor substrate-binding pocket; other site 1097669004210 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1097669004211 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1097669004212 active site 1097669004213 Acyl transferase domain; Region: Acyl_transf_1; pfam00698 1097669004214 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1097669004215 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1097669004216 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1097669004217 Enoylreductase; Region: PKS_ER; smart00829 1097669004218 NAD(P) binding site [chemical binding]; other site 1097669004219 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1097669004220 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1097669004221 putative NADP binding site [chemical binding]; other site 1097669004222 active site 1097669004223 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1097669004224 acyl-CoA synthetase; Validated; Region: PRK05850 1097669004225 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1097669004226 acyl-activating enzyme (AAE) consensus motif; other site 1097669004227 active site 1097669004228 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1097669004229 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1097669004230 NAD(P) binding site [chemical binding]; other site 1097669004231 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1097669004232 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1097669004233 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1097669004234 CoenzymeA binding site [chemical binding]; other site 1097669004235 subunit interaction site [polypeptide binding]; other site 1097669004236 PHB binding site; other site 1097669004237 Nitronate monooxygenase; Region: NMO; pfam03060 1097669004238 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1097669004239 FMN binding site [chemical binding]; other site 1097669004240 substrate binding site [chemical binding]; other site 1097669004241 putative catalytic residue [active] 1097669004242 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1097669004243 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 1097669004244 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1097669004245 HIGH motif; other site 1097669004246 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1097669004247 active site 1097669004248 KMSKS motif; other site 1097669004249 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 1097669004250 tRNA binding surface [nucleotide binding]; other site 1097669004251 anticodon binding site; other site 1097669004252 DNA polymerase IV; Provisional; Region: PRK03348 1097669004253 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1097669004254 active site 1097669004255 DNA binding site [nucleotide binding] 1097669004256 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1097669004257 active site 1097669004258 homodimer interface [polypeptide binding]; other site 1097669004259 homotetramer interface [polypeptide binding]; other site 1097669004260 lipoprotein signal peptidase; Provisional; Region: PRK14764 1097669004261 lipoprotein signal peptidase; Provisional; Region: PRK14787 1097669004262 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1097669004263 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1097669004264 active site 1097669004265 Uncharacterized protein conserved in bacteria, putative lipoprotein [Function unknown]; Region: LprI; COG4461 1097669004266 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 1097669004267 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 1097669004268 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1097669004269 apolar tunnel; other site 1097669004270 heme binding site [chemical binding]; other site 1097669004271 dimerization interface [polypeptide binding]; other site 1097669004272 short chain dehydrogenase; Provisional; Region: PRK05866 1097669004273 classical (c) SDRs; Region: SDR_c; cd05233 1097669004274 NAD(P) binding site [chemical binding]; other site 1097669004275 active site 1097669004276 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1097669004277 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1097669004278 NAD(P) binding site [chemical binding]; other site 1097669004279 active site 1097669004280 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1097669004281 hydrophobic ligand binding site; other site 1097669004282 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1097669004283 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 1097669004284 active site 1097669004285 PHP Thumb interface [polypeptide binding]; other site 1097669004286 metal binding site [ion binding]; metal-binding site 1097669004287 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1097669004288 generic binding surface II; other site 1097669004289 generic binding surface I; other site 1097669004290 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1097669004291 PPE family; Region: PPE; pfam00823 1097669004292 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1097669004293 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1097669004294 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1097669004295 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1097669004296 acyl-activating enzyme (AAE) consensus motif; other site 1097669004297 putative AMP binding site [chemical binding]; other site 1097669004298 putative active site [active] 1097669004299 putative CoA binding site [chemical binding]; other site 1097669004300 glycerol-3-phosphate acyltransferase; Reviewed; Region: PRK11915 1097669004301 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 1097669004302 putative acyl-acceptor binding pocket; other site 1097669004303 fumarate reductase, flavoprotein subunit; Region: fum_red_Fp; TIGR01176 1097669004304 L-aspartate oxidase; Provisional; Region: PRK06175 1097669004305 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1097669004306 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 1097669004307 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1097669004308 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 1097669004309 D-subunit interface [polypeptide binding]; other site 1097669004310 Iron-sulfur protein interface; other site 1097669004311 proximal quinone binding site [chemical binding]; other site 1097669004312 distal quinone binding site [chemical binding]; other site 1097669004313 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 1097669004314 Iron-sulfur protein interface; other site 1097669004315 proximal quinone binding site [chemical binding]; other site 1097669004316 C-subunit interface; other site 1097669004317 distal quinone binding site; other site 1097669004318 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1097669004319 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1097669004320 MMPL family; Region: MMPL; pfam03176 1097669004321 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1097669004322 threonine dehydratase; Validated; Region: PRK08639 1097669004323 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1097669004324 tetramer interface [polypeptide binding]; other site 1097669004325 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1097669004326 catalytic residue [active] 1097669004327 C-terminal regulatory domain of Threonine dehydratase; Region: Thr_dehydrat_C; pfam00585 1097669004328 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 1097669004329 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 1097669004330 putative active site [active] 1097669004331 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 1097669004332 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 1097669004333 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 1097669004334 catalytic site [active] 1097669004335 active site 1097669004336 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1097669004337 malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401 1097669004338 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 1097669004339 active site 1097669004340 catalytic site [active] 1097669004341 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1097669004342 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1097669004343 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1097669004344 active site 1097669004345 catalytic site [active] 1097669004346 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1097669004347 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1097669004348 NlpC/P60 family; Region: NLPC_P60; pfam00877 1097669004349 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 1097669004350 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1097669004351 inhibitor-cofactor binding pocket; inhibition site 1097669004352 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1097669004353 catalytic residue [active] 1097669004354 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 1097669004355 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 1097669004356 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1097669004357 catalytic residue [active] 1097669004358 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1097669004359 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 1097669004360 biotin synthase; Validated; Region: PRK06256 1097669004361 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1097669004362 FeS/SAM binding site; other site 1097669004363 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1097669004364 Protein of unknown function (DUF2567); Region: DUF2567; pfam10821 1097669004365 Secretory lipase; Region: LIP; pfam03583 1097669004366 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 1097669004367 nudix motif; other site 1097669004368 quinolinate synthetase; Provisional; Region: PRK09375 1097669004369 L-aspartate oxidase; Provisional; Region: PRK07804 1097669004370 L-aspartate oxidase; Provisional; Region: PRK06175 1097669004371 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1097669004372 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 1097669004373 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1097669004374 dimerization interface [polypeptide binding]; other site 1097669004375 active site 1097669004376 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1097669004377 S-adenosylmethionine binding site [chemical binding]; other site 1097669004378 deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026 1097669004379 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 1097669004380 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1097669004381 NAD binding site [chemical binding]; other site 1097669004382 dimerization interface [polypeptide binding]; other site 1097669004383 product binding site; other site 1097669004384 substrate binding site [chemical binding]; other site 1097669004385 zinc binding site [ion binding]; other site 1097669004386 catalytic residues [active] 1097669004387 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 1097669004388 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1097669004389 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1097669004390 homodimer interface [polypeptide binding]; other site 1097669004391 catalytic residue [active] 1097669004392 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1097669004393 4-fold oligomerization interface [polypeptide binding]; other site 1097669004394 putative active site pocket [active] 1097669004395 metal binding residues [ion binding]; metal-binding site 1097669004396 3-fold/trimer interface [polypeptide binding]; other site 1097669004397 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 1097669004398 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1097669004399 putative active site [active] 1097669004400 oxyanion strand; other site 1097669004401 catalytic triad [active] 1097669004402 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1097669004403 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1097669004404 catalytic residues [active] 1097669004405 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1097669004406 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1097669004407 active site 1097669004408 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1097669004409 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1097669004410 substrate binding site [chemical binding]; other site 1097669004411 glutamase interaction surface [polypeptide binding]; other site 1097669004412 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 1097669004413 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 1097669004414 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1097669004415 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1097669004416 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1097669004417 catalytic triad [active] 1097669004418 anthranilate synthase component I; Provisional; Region: PRK13571 1097669004419 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1097669004420 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1097669004421 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534 1097669004422 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1097669004423 active site 1097669004424 ribulose/triose binding site [chemical binding]; other site 1097669004425 phosphate binding site [ion binding]; other site 1097669004426 substrate (anthranilate) binding pocket [chemical binding]; other site 1097669004427 product (indole) binding pocket [chemical binding]; other site 1097669004428 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1097669004429 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1097669004430 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1097669004431 catalytic residue [active] 1097669004432 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1097669004433 substrate binding site [chemical binding]; other site 1097669004434 active site 1097669004435 catalytic residues [active] 1097669004436 heterodimer interface [polypeptide binding]; other site 1097669004437 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK13108 1097669004438 Prolipoprotein diacylglyceryltransferase [Cell envelope biogenesis, outer membrane]; Region: Lgt; COG0682 1097669004439 TM2 domain; Region: TM2; pfam05154 1097669004440 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 1097669004441 pyruvate kinase; Provisional; Region: PRK06247 1097669004442 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1097669004443 domain interfaces; other site 1097669004444 active site 1097669004445 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 1097669004446 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1097669004447 active site 1097669004448 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1097669004449 catalytic triad [active] 1097669004450 dimer interface [polypeptide binding]; other site 1097669004451 Uncharacterized conserved protein [Function unknown]; Region: COG2898 1097669004452 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1097669004453 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 1097669004454 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1097669004455 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1097669004456 Walker A/P-loop; other site 1097669004457 Walker A/P-loop; other site 1097669004458 ATP binding site [chemical binding]; other site 1097669004459 ATP binding site [chemical binding]; other site 1097669004460 Q-loop/lid; other site 1097669004461 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 1097669004462 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1097669004463 Walker A/P-loop; other site 1097669004464 ATP binding site [chemical binding]; other site 1097669004465 Q-loop/lid; other site 1097669004466 ABC transporter signature motif; other site 1097669004467 Walker B; other site 1097669004468 D-loop; other site 1097669004469 H-loop/switch region; other site 1097669004470 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1097669004471 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1097669004472 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1097669004473 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1097669004474 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 1097669004475 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 1097669004476 cyclase homology domain; Region: CHD; cd07302 1097669004477 nucleotidyl binding site; other site 1097669004478 metal binding site [ion binding]; metal-binding site 1097669004479 dimer interface [polypeptide binding]; other site 1097669004480 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 1097669004481 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1097669004482 active site 1097669004483 phosphorylation site [posttranslational modification] 1097669004484 intermolecular recognition site; other site 1097669004485 dimerization interface [polypeptide binding]; other site 1097669004486 ANTAR domain; Region: ANTAR; pfam03861 1097669004487 lipid-transfer protein; Provisional; Region: PRK06059 1097669004488 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1097669004489 active site 1097669004490 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1097669004491 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1097669004492 DUF35 OB-fold domain; Region: DUF35; pfam01796 1097669004493 DNA polymerase I; Provisional; Region: PRK05755 1097669004494 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1097669004495 active site 1097669004496 metal binding site 1 [ion binding]; metal-binding site 1097669004497 putative 5' ssDNA interaction site; other site 1097669004498 metal binding site 3; metal-binding site 1097669004499 metal binding site 2 [ion binding]; metal-binding site 1097669004500 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1097669004501 putative DNA binding site [nucleotide binding]; other site 1097669004502 putative metal binding site [ion binding]; other site 1097669004503 3'-5' exonuclease; Region: 35EXOc; smart00474 1097669004504 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1097669004505 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1097669004506 active site 1097669004507 DNA binding site [nucleotide binding] 1097669004508 catalytic site [active] 1097669004509 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 1097669004510 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1097669004511 RNA binding site [nucleotide binding]; other site 1097669004512 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1097669004513 RNA binding site [nucleotide binding]; other site 1097669004514 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1097669004515 RNA binding site [nucleotide binding]; other site 1097669004516 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1097669004517 RNA binding site [nucleotide binding]; other site 1097669004518 dephospho-CoA kinase/protein folding accessory domain-containing protein; Provisional; Region: coaE; PRK03333 1097669004519 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1097669004520 CoA-binding site [chemical binding]; other site 1097669004521 ATP-binding [chemical binding]; other site 1097669004522 Uncharacterized conserved protein [Function unknown]; Region: GrpB; COG2320 1097669004523 Predicted RNA-binding protein, associated with RNAses E/G family [General function prediction only]; Region: COG2306 1097669004524 excinuclease ABC subunit B; Provisional; Region: PRK05298 1097669004525 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1097669004526 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1097669004527 nucleotide binding region [chemical binding]; other site 1097669004528 ATP-binding site [chemical binding]; other site 1097669004529 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1097669004530 UvrB/uvrC motif; Region: UVR; pfam02151 1097669004531 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1097669004532 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1097669004533 putative substrate translocation pore; other site 1097669004534 Predicted membrane protein [Function unknown]; Region: COG5305 1097669004535 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1097669004536 Ligand Binding Site [chemical binding]; other site 1097669004537 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1097669004538 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1097669004539 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1097669004540 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1097669004541 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1097669004542 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1097669004543 Predicted esterase [General function prediction only]; Region: COG0627 1097669004544 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 1097669004545 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1097669004546 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1097669004547 dimer interface [polypeptide binding]; other site 1097669004548 putative anticodon binding site; other site 1097669004549 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1097669004550 motif 1; other site 1097669004551 dimer interface [polypeptide binding]; other site 1097669004552 active site 1097669004553 motif 2; other site 1097669004554 motif 3; other site 1097669004555 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1097669004556 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1097669004557 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1097669004558 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1097669004559 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1097669004560 23S rRNA binding site [nucleotide binding]; other site 1097669004561 L21 binding site [polypeptide binding]; other site 1097669004562 L13 binding site [polypeptide binding]; other site 1097669004563 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1097669004564 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1097669004565 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 1097669004566 PE family; Region: PE; pfam00934 1097669004567 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1097669004568 cyclase homology domain; Region: CHD; cd07302 1097669004569 nucleotidyl binding site; other site 1097669004570 metal binding site [ion binding]; metal-binding site 1097669004571 dimer interface [polypeptide binding]; other site 1097669004572 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1097669004573 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1097669004574 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1097669004575 dimer interface [polypeptide binding]; other site 1097669004576 motif 1; other site 1097669004577 active site 1097669004578 motif 2; other site 1097669004579 motif 3; other site 1097669004580 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1097669004581 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1097669004582 putative tRNA-binding site [nucleotide binding]; other site 1097669004583 B3/4 domain; Region: B3_4; pfam03483 1097669004584 tRNA synthetase B5 domain; Region: B5; smart00874 1097669004585 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1097669004586 dimer interface [polypeptide binding]; other site 1097669004587 motif 1; other site 1097669004588 motif 3; other site 1097669004589 motif 2; other site 1097669004590 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1097669004591 PE family; Region: PE; pfam00934 1097669004592 N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850 1097669004593 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1097669004594 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1097669004595 heterotetramer interface [polypeptide binding]; other site 1097669004596 active site pocket [active] 1097669004597 cleavage site 1097669004598 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 1097669004599 feedback inhibition sensing region; other site 1097669004600 homohexameric interface [polypeptide binding]; other site 1097669004601 nucleotide binding site [chemical binding]; other site 1097669004602 N-acetyl-L-glutamate binding site [chemical binding]; other site 1097669004603 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 1097669004604 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1097669004605 inhibitor-cofactor binding pocket; inhibition site 1097669004606 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1097669004607 catalytic residue [active] 1097669004608 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1097669004609 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1097669004610 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1097669004611 arginine repressor; Provisional; Region: PRK03341 1097669004612 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1097669004613 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1097669004614 argininosuccinate synthase; Provisional; Region: PRK13820 1097669004615 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1097669004616 ANP binding site [chemical binding]; other site 1097669004617 Substrate Binding Site II [chemical binding]; other site 1097669004618 Substrate Binding Site I [chemical binding]; other site 1097669004619 argininosuccinate lyase; Provisional; Region: PRK00855 1097669004620 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1097669004621 active sites [active] 1097669004622 tetramer interface [polypeptide binding]; other site 1097669004623 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 1097669004624 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 1097669004625 malonyl-CoA binding site [chemical binding]; other site 1097669004626 dimer interface [polypeptide binding]; other site 1097669004627 active site 1097669004628 product binding site; other site 1097669004629 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1097669004630 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1097669004631 active site 1097669004632 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1097669004633 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1097669004634 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1097669004635 Enoylreductase; Region: PKS_ER; smart00829 1097669004636 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1097669004637 NAD(P) binding site [chemical binding]; other site 1097669004638 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 1097669004639 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1097669004640 putative NADP binding site [chemical binding]; other site 1097669004641 active site 1097669004642 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1097669004643 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1097669004644 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1097669004645 active site 1097669004646 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1097669004647 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1097669004648 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1097669004649 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1097669004650 Enoylreductase; Region: PKS_ER; smart00829 1097669004651 NAD(P) binding site [chemical binding]; other site 1097669004652 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1097669004653 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 1097669004654 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1097669004655 putative NADP binding site [chemical binding]; other site 1097669004656 active site 1097669004657 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1097669004658 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1097669004659 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1097669004660 active site 1097669004661 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1097669004662 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1097669004663 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1097669004664 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 1097669004665 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 1097669004666 malonyl-CoA binding site [chemical binding]; other site 1097669004667 dimer interface [polypeptide binding]; other site 1097669004668 active site 1097669004669 product binding site; other site 1097669004670 Cytochrome P450; Region: p450; cl12078 1097669004671 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1097669004672 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1097669004673 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1097669004674 ABC transporter; Region: ABC_tran_2; pfam12848 1097669004675 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1097669004676 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1097669004677 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1097669004678 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 1097669004679 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1097669004680 putative substrate translocation pore; other site 1097669004681 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1097669004682 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1097669004683 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1097669004684 dimerization interface [polypeptide binding]; other site 1097669004685 putative DNA binding site [nucleotide binding]; other site 1097669004686 putative Zn2+ binding site [ion binding]; other site 1097669004687 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1097669004688 active site residue [active] 1097669004689 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1097669004690 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1097669004691 ligand binding site [chemical binding]; other site 1097669004692 flexible hinge region; other site 1097669004693 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1097669004694 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 1097669004695 putative catalytic residues [active] 1097669004696 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 1097669004697 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1097669004698 catalytic residues [active] 1097669004699 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1097669004700 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1097669004701 active site 1097669004702 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 1097669004703 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1097669004704 substrate binding pocket [chemical binding]; other site 1097669004705 membrane-bound complex binding site; other site 1097669004706 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 1097669004707 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1097669004708 FeS/SAM binding site; other site 1097669004709 DivIVA protein; Region: DivIVA; pfam05103 1097669004710 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1097669004711 acyl-CoA synthetase; Validated; Region: PRK07868 1097669004712 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 1097669004713 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1097669004714 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1097669004715 acyl-activating enzyme (AAE) consensus motif; other site 1097669004716 AMP binding site [chemical binding]; other site 1097669004717 active site 1097669004718 CoA binding site [chemical binding]; other site 1097669004719 Uncharacterized conserved protein [Function unknown]; Region: COG2835 1097669004720 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1097669004721 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1097669004722 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1097669004723 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1097669004724 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1097669004725 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 1097669004726 Walker A/P-loop; other site 1097669004727 ATP binding site [chemical binding]; other site 1097669004728 Q-loop/lid; other site 1097669004729 ABC transporter signature motif; other site 1097669004730 Walker B; other site 1097669004731 D-loop; other site 1097669004732 H-loop/switch region; other site 1097669004733 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1097669004734 active site 1097669004735 DNA binding site [nucleotide binding] 1097669004736 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1097669004737 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1097669004738 active site 1097669004739 HIGH motif; other site 1097669004740 dimer interface [polypeptide binding]; other site 1097669004741 KMSKS motif; other site 1097669004742 S4 RNA-binding domain; Region: S4; smart00363 1097669004743 RNA binding surface [nucleotide binding]; other site 1097669004744 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1097669004745 Tetratrico peptide repeat; Region: TPR_5; pfam12688 1097669004746 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1097669004747 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 1097669004748 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 1097669004749 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1097669004750 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1097669004751 RNA binding surface [nucleotide binding]; other site 1097669004752 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1097669004753 S-adenosylmethionine binding site [chemical binding]; other site 1097669004754 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 1097669004755 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1097669004756 DNA repair protein RecN; Region: recN; TIGR00634 1097669004757 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1097669004758 Walker A/P-loop; other site 1097669004759 ATP binding site [chemical binding]; other site 1097669004760 Q-loop/lid; other site 1097669004761 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1097669004762 ABC transporter signature motif; other site 1097669004763 Walker B; other site 1097669004764 D-loop; other site 1097669004765 H-loop/switch region; other site 1097669004766 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 1097669004767 Thiamine pyrophosphokinase; Region: TPK; cl08415 1097669004768 Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555 1097669004769 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 1097669004770 CTP synthetase; Validated; Region: pyrG; PRK05380 1097669004771 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1097669004772 Catalytic site [active] 1097669004773 active site 1097669004774 UTP binding site [chemical binding]; other site 1097669004775 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1097669004776 active site 1097669004777 putative oxyanion hole; other site 1097669004778 catalytic triad [active] 1097669004779 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1097669004780 dimer interface [polypeptide binding]; other site 1097669004781 ADP-ribose binding site [chemical binding]; other site 1097669004782 active site 1097669004783 nudix motif; other site 1097669004784 metal binding site [ion binding]; metal-binding site 1097669004785 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1097669004786 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1097669004787 active site 1097669004788 DNA binding site [nucleotide binding] 1097669004789 Int/Topo IB signature motif; other site 1097669004790 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1097669004791 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1097669004792 active site 1097669004793 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1097669004794 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1097669004795 S-adenosylmethionine binding site [chemical binding]; other site 1097669004796 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 1097669004797 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1097669004798 PPE family; Region: PPE; pfam00823 1097669004799 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1097669004800 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1097669004801 PPE family; Region: PPE; pfam00823 1097669004802 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1097669004803 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1097669004804 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1097669004805 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1097669004806 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1097669004807 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1097669004808 P-loop; other site 1097669004809 Magnesium ion binding site [ion binding]; other site 1097669004810 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1097669004811 Magnesium ion binding site [ion binding]; other site 1097669004812 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 1097669004813 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 1097669004814 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1097669004815 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1097669004816 RNA binding surface [nucleotide binding]; other site 1097669004817 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1097669004818 active site 1097669004819 cytidylate kinase; Provisional; Region: cmk; PRK00023 1097669004820 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1097669004821 CMP-binding site; other site 1097669004822 The sites determining sugar specificity; other site 1097669004823 GTP-binding protein Der; Reviewed; Region: PRK03003 1097669004824 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1097669004825 GTP/Mg2+ binding site [chemical binding]; other site 1097669004826 Switch I region; other site 1097669004827 G2 box; other site 1097669004828 Switch II region; other site 1097669004829 G3 box; other site 1097669004830 G4 box; other site 1097669004831 G5 box; other site 1097669004832 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1097669004833 G1 box; other site 1097669004834 GTP/Mg2+ binding site [chemical binding]; other site 1097669004835 Switch I region; other site 1097669004836 G2 box; other site 1097669004837 G3 box; other site 1097669004838 Switch II region; other site 1097669004839 G4 box; other site 1097669004840 G5 box; other site 1097669004841 short chain dehydrogenase; Provisional; Region: PRK07060 1097669004842 classical (c) SDRs; Region: SDR_c; cd05233 1097669004843 NAD(P) binding site [chemical binding]; other site 1097669004844 active site 1097669004845 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 1097669004846 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1097669004847 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1097669004848 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 1097669004849 Cupin domain; Region: Cupin_2; cl17218 1097669004850 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 1097669004851 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1097669004852 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1097669004853 putative switch regulator; other site 1097669004854 non-specific DNA interactions [nucleotide binding]; other site 1097669004855 DNA binding site [nucleotide binding] 1097669004856 sequence specific DNA binding site [nucleotide binding]; other site 1097669004857 putative cAMP binding site [chemical binding]; other site 1097669004858 Bacterial transcriptional regulator; Region: IclR; pfam01614 1097669004859 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 1097669004860 putative active site [active] 1097669004861 homotetrameric interface [polypeptide binding]; other site 1097669004862 metal binding site [ion binding]; metal-binding site 1097669004863 biotin carboxylase-like protein; Validated; Region: PRK06524 1097669004864 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1097669004865 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1097669004866 Beta-lactamase; Region: Beta-lactamase; pfam00144 1097669004867 Predicted transcriptional regulators [Transcription]; Region: COG1733 1097669004868 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1097669004869 dimerization interface [polypeptide binding]; other site 1097669004870 putative DNA binding site [nucleotide binding]; other site 1097669004871 putative Zn2+ binding site [ion binding]; other site 1097669004872 Predicted transcriptional regulators [Transcription]; Region: COG1733 1097669004873 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1097669004874 FAD binding domain; Region: FAD_binding_4; pfam01565 1097669004875 Berberine and berberine like; Region: BBE; pfam08031 1097669004876 TIGR03086 family protein; Region: TIGR03086 1097669004877 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1097669004878 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1097669004879 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1097669004880 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1097669004881 Beta-lactamase; Region: Beta-lactamase; pfam00144 1097669004882 succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407 1097669004883 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101 1097669004884 NAD(P) binding site [chemical binding]; other site 1097669004885 catalytic residues [active] 1097669004886 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 1097669004887 putative catalytic residue [active] 1097669004888 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes [Energy production and conversion]; Region: AceF; COG0508 1097669004889 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1097669004890 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 1097669004891 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_1; cd09319 1097669004892 gating phenylalanine in ion channel; other site 1097669004893 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 1097669004894 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1097669004895 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 1097669004896 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 1097669004897 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1097669004898 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 1097669004899 putative substrate translocation pore; other site 1097669004900 Domain of unknown function (DUF1876); Region: DUF1876; pfam08962 1097669004901 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1097669004902 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1097669004903 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1097669004904 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1097669004905 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4423 1097669004906 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3742 1097669004907 putative active site [active] 1097669004908 Protein tyrosine kinase; Region: Pkinase_Tyr; pfam07714 1097669004909 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1097669004910 active site 1097669004911 ATP binding site [chemical binding]; other site 1097669004912 substrate binding site [chemical binding]; other site 1097669004913 activation loop (A-loop); other site 1097669004914 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1097669004915 Thioredoxin; Region: Thioredoxin_4; cl17273 1097669004916 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 1097669004917 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 1097669004918 active site 1097669004919 metal binding site [ion binding]; metal-binding site 1097669004920 nudix motif; other site 1097669004921 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1097669004922 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1097669004923 active site 1097669004924 ATP binding site [chemical binding]; other site 1097669004925 substrate binding site [chemical binding]; other site 1097669004926 activation loop (A-loop); other site 1097669004927 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1097669004928 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1097669004929 phosphopeptide binding site; other site 1097669004930 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1097669004931 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1097669004932 phosphopeptide binding site; other site 1097669004933 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 1097669004934 The Eye Pigment Precursor Transporter (EPP) Family protein; Region: 3a01204; TIGR00955 1097669004935 Walker A/P-loop; other site 1097669004936 ATP binding site [chemical binding]; other site 1097669004937 Q-loop/lid; other site 1097669004938 ABC transporter signature motif; other site 1097669004939 Walker B; other site 1097669004940 D-loop; other site 1097669004941 H-loop/switch region; other site 1097669004942 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1097669004943 acyl-CoA synthetase; Provisional; Region: PRK13388 1097669004944 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1097669004945 acyl-activating enzyme (AAE) consensus motif; other site 1097669004946 AMP binding site [chemical binding]; other site 1097669004947 active site 1097669004948 CoA binding site [chemical binding]; other site 1097669004949 hypothetical protein; Provisional; Region: PRK06185 1097669004950 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1097669004951 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1097669004952 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1097669004953 Integrase core domain; Region: rve; pfam00665 1097669004954 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 1097669004955 putative homotetramer interface [polypeptide binding]; other site 1097669004956 putative homodimer interface [polypeptide binding]; other site 1097669004957 putative allosteric switch controlling residues; other site 1097669004958 putative metal binding site [ion binding]; other site 1097669004959 putative homodimer-homodimer interface [polypeptide binding]; other site 1097669004960 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1097669004961 PE family; Region: PE; pfam00934 1097669004962 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 1097669004963 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813 1097669004964 dimer interface [polypeptide binding]; other site 1097669004965 active site 1097669004966 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1097669004967 substrate binding site [chemical binding]; other site 1097669004968 catalytic residue [active] 1097669004969 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 1097669004970 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1097669004971 metal binding site [ion binding]; metal-binding site 1097669004972 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 1097669004973 FAD binding domain; Region: FAD_binding_4; pfam01565 1097669004974 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 1097669004975 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 1097669004976 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1097669004977 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1097669004978 Bacterial transcriptional regulator; Region: IclR; pfam01614 1097669004979 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1097669004980 FAD binding domain; Region: FAD_binding_4; pfam01565 1097669004981 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1097669004982 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1097669004983 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1097669004984 Cytochrome P450; Region: p450; cl12078 1097669004985 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362 1097669004986 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 1097669004987 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 1097669004988 Protein of unknown function (DUF690); Region: DUF690; pfam05108 1097669004989 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1097669004990 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1097669004991 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1097669004992 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1097669004993 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1097669004994 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1097669004995 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1097669004996 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1097669004997 Cytochrome P450; Region: p450; cl12078 1097669004998 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1097669004999 PE family; Region: PE; pfam00934 1097669005000 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1097669005001 PPE family; Region: PPE; pfam00823 1097669005002 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1097669005003 PE family; Region: PE; pfam00934 1097669005004 pseudo 1097669005005 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1097669005006 EspG family; Region: ESX-1_EspG; pfam14011 1097669005007 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 1097669005008 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1097669005009 catalytic residues [active] 1097669005010 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 1097669005011 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 1097669005012 active site 1097669005013 catalytic residues [active] 1097669005014 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 1097669005015 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 1097669005016 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1097669005017 Walker A motif; other site 1097669005018 ATP binding site [chemical binding]; other site 1097669005019 Walker B motif; other site 1097669005020 arginine finger; other site 1097669005021 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1097669005022 PPE family; Region: PPE; pfam00823 1097669005023 PE-PPE domain; Region: PE-PPE; pfam08237 1097669005024 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1097669005025 PPE family; Region: PPE; pfam00823 1097669005026 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1097669005027 PPE family; Region: PPE; pfam00823 1097669005028 PE family; Region: PE; pfam00934 1097669005029 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1097669005030 PE family; Region: PE; pfam00934 1097669005032 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1097669005033 PPE family; Region: PPE; pfam00823 1097669005034 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1097669005035 PPE family; Region: PPE; pfam00823 1097669005036 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1097669005037 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1097669005038 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1097669005039 MgtC family; Region: MgtC; pfam02308 1097669005040 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1097669005041 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1097669005042 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 1097669005043 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 1097669005044 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 1097669005045 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1097669005046 hypothetical protein; Validated; Region: PRK07121 1097669005047 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 1097669005048 ABC transporter transmembrane region 2; Region: ABC_membrane_2; pfam06472 1097669005049 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 1097669005050 hypothetical protein; Provisional; Region: PRK05858 1097669005051 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1097669005052 PYR/PP interface [polypeptide binding]; other site 1097669005053 dimer interface [polypeptide binding]; other site 1097669005054 TPP binding site [chemical binding]; other site 1097669005055 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1097669005056 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 1097669005057 TPP-binding site; other site 1097669005058 dimer interface [polypeptide binding]; other site 1097669005059 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 1097669005060 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 1097669005061 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1097669005062 nucleotide binding region [chemical binding]; other site 1097669005063 ATP-binding site [chemical binding]; other site 1097669005064 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1097669005065 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 1097669005066 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1097669005067 Uncharacterized conserved protein (small basic protein) [Function unknown]; Region: Sbp; COG3856 1097669005068 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 1097669005069 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1097669005070 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1097669005071 lipoyl attachment site [posttranslational modification]; other site 1097669005072 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1097669005073 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1097669005074 phosphopeptide binding site; other site 1097669005075 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1097669005076 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1097669005077 DNA binding residues [nucleotide binding] 1097669005078 Bifunctional nuclease; Region: DNase-RNase; pfam02577 1097669005079 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1097669005080 DNA binding residues [nucleotide binding] 1097669005081 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1097669005082 putative dimer interface [polypeptide binding]; other site 1097669005083 glycine dehydrogenase; Provisional; Region: PRK05367 1097669005084 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1097669005085 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1097669005086 tetramer interface [polypeptide binding]; other site 1097669005087 catalytic residue [active] 1097669005088 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1097669005089 tetramer interface [polypeptide binding]; other site 1097669005090 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1097669005091 catalytic residue [active] 1097669005092 haloalkane dehalogenase; Provisional; Region: PRK03204 1097669005093 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1097669005094 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 1097669005095 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 1097669005096 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1097669005097 metal ion-dependent adhesion site (MIDAS); other site 1097669005098 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 1097669005099 active site 1097669005100 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 1097669005101 putative active site [active] 1097669005102 Domain of unknown function DUF21; Region: DUF21; pfam01595 1097669005103 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1097669005104 FOG: CBS domain [General function prediction only]; Region: COG0517 1097669005105 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1097669005106 Domain of unknown function DUF21; Region: DUF21; pfam01595 1097669005107 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1097669005108 Transporter associated domain; Region: CorC_HlyC; smart01091 1097669005109 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 1097669005110 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1097669005111 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1097669005112 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1097669005113 active site 1097669005114 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1097669005115 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1097669005116 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1097669005117 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1097669005118 Predicted transcriptional regulator [Transcription]; Region: COG3682 1097669005119 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1097669005120 CoenzymeA binding site [chemical binding]; other site 1097669005121 subunit interaction site [polypeptide binding]; other site 1097669005122 PHB binding site; other site 1097669005123 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 1097669005124 alpha-gamma subunit interface [polypeptide binding]; other site 1097669005125 beta-gamma subunit interface [polypeptide binding]; other site 1097669005126 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 1097669005127 gamma-beta subunit interface [polypeptide binding]; other site 1097669005128 alpha-beta subunit interface [polypeptide binding]; other site 1097669005129 urease subunit alpha; Reviewed; Region: ureC; PRK13206 1097669005130 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 1097669005131 subunit interactions [polypeptide binding]; other site 1097669005132 active site 1097669005133 flap region; other site 1097669005134 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 1097669005135 UreF; Region: UreF; pfam01730 1097669005136 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1097669005137 UreD urease accessory protein; Region: UreD; cl00530 1097669005138 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1097669005139 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1097669005140 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 1097669005141 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1097669005142 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1097669005143 classical (c) SDRs; Region: SDR_c; cd05233 1097669005144 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 1097669005145 NAD(P) binding site [chemical binding]; other site 1097669005146 active site 1097669005147 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 1097669005148 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1097669005149 sulfate transport protein; Provisional; Region: cysT; CHL00187 1097669005150 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1097669005151 dimer interface [polypeptide binding]; other site 1097669005152 conserved gate region; other site 1097669005153 putative PBP binding loops; other site 1097669005154 ABC-ATPase subunit interface; other site 1097669005155 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 1097669005156 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1097669005157 Walker A/P-loop; other site 1097669005158 ATP binding site [chemical binding]; other site 1097669005159 Q-loop/lid; other site 1097669005160 ABC transporter signature motif; other site 1097669005161 Walker B; other site 1097669005162 D-loop; other site 1097669005163 H-loop/switch region; other site 1097669005164 TOBE domain; Region: TOBE; pfam03459 1097669005165 Fibronectin-attachment protein (FAP); Region: FAP; pfam07174 1097669005166 Predicted membrane protein [Function unknown]; Region: COG2261 1097669005167 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 1097669005168 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822 1097669005169 putative NAD(P) binding site [chemical binding]; other site 1097669005170 putative substrate binding site [chemical binding]; other site 1097669005171 catalytic Zn binding site [ion binding]; other site 1097669005172 structural Zn binding site [ion binding]; other site 1097669005173 CAAX protease self-immunity; Region: Abi; pfam02517 1097669005174 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 1097669005175 MOSC domain; Region: MOSC; pfam03473 1097669005176 short chain dehydrogenase; Provisional; Region: PRK07825 1097669005177 classical (c) SDRs; Region: SDR_c; cd05233 1097669005178 NAD(P) binding site [chemical binding]; other site 1097669005179 active site 1097669005180 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1097669005181 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1097669005182 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1097669005183 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1097669005184 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 1097669005185 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1097669005186 active site 1097669005187 hypothetical protein; Provisional; Region: PRK12320 1097669005188 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1097669005189 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 1097669005190 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1097669005191 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1097669005192 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1097669005193 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 1097669005194 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 1097669005195 active site 1097669005196 substrate binding site [chemical binding]; other site 1097669005197 FMN binding site [chemical binding]; other site 1097669005198 putative catalytic residues [active] 1097669005199 Uncharacterized conserved protein [Function unknown]; Region: COG5579 1097669005200 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1097669005201 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 1097669005202 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 1097669005203 heme binding site [chemical binding]; other site 1097669005204 ferroxidase pore; other site 1097669005205 ferroxidase diiron center [ion binding]; other site 1097669005206 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1097669005207 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1097669005208 putative substrate translocation pore; other site 1097669005209 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1097669005210 putative substrate translocation pore; other site 1097669005211 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cl00333 1097669005212 23S rRNA interface [nucleotide binding]; other site 1097669005213 L3 interface [polypeptide binding]; other site 1097669005214 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1097669005215 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1097669005216 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1097669005217 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 1097669005218 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1097669005219 Cytochrome P450; Region: p450; cl12078 1097669005220 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 1097669005221 short chain dehydrogenase; Provisional; Region: PRK08267 1097669005222 classical (c) SDR, subgroup 9; Region: SDR_c9; cd08931 1097669005223 putative NAD(P) binding site [chemical binding]; other site 1097669005224 active site 1097669005225 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1097669005226 hydrophobic ligand binding site; other site 1097669005227 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1097669005228 chorismate mutase; Provisional; Region: PRK09269 1097669005229 chorismate mutase, putative; Region: CM_mono2; TIGR01806 1097669005230 Putative esterase; Region: Esterase; pfam00756 1097669005231 Leucine carboxyl methyltransferase; Region: LCM; cl01306 1097669005232 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1097669005233 Leucine carboxyl methyltransferase; Region: LCM; cl01306 1097669005234 Uncharacterized conserved protein [Function unknown]; Region: COG2353 1097669005235 Nitronate monooxygenase; Region: NMO; pfam03060 1097669005236 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1097669005237 FMN binding site [chemical binding]; other site 1097669005238 substrate binding site [chemical binding]; other site 1097669005239 putative catalytic residue [active] 1097669005240 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 2; Region: FDH_like_2; cd08284 1097669005241 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1097669005242 catalytic Zn binding site [ion binding]; other site 1097669005243 NAD(P) binding site [chemical binding]; other site 1097669005244 structural Zn binding site [ion binding]; other site 1097669005245 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1097669005246 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1097669005247 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1097669005248 putative active site [active] 1097669005249 dimerization interface [polypeptide binding]; other site 1097669005250 putative tRNAtyr binding site [nucleotide binding]; other site 1097669005251 Domain of unknown function DUF77; Region: DUF77; pfam01910 1097669005252 Macro domain, Unknown family 2. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_2; cd03330 1097669005253 putative ADP-ribose binding site [chemical binding]; other site 1097669005254 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1097669005255 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1097669005256 cyclase homology domain; Region: CHD; cd07302 1097669005257 nucleotidyl binding site; other site 1097669005258 metal binding site [ion binding]; metal-binding site 1097669005259 dimer interface [polypeptide binding]; other site 1097669005260 competence damage-inducible protein A; Provisional; Region: PRK00549 1097669005261 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1097669005262 putative MPT binding site; other site 1097669005263 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 1097669005264 putative sialic acid transporter; Region: 2A0112; TIGR00891 1097669005265 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1097669005266 putative substrate translocation pore; other site 1097669005267 Predicted membrane protein [Function unknown]; Region: COG1950 1097669005268 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1097669005269 anti sigma factor interaction site; other site 1097669005270 regulatory phosphorylation site [posttranslational modification]; other site 1097669005271 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1097669005272 Domain of unknown function (DUF4262); Region: DUF4262; pfam14081 1097669005273 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 1097669005274 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 1097669005275 dimer interface [polypeptide binding]; other site 1097669005276 active site 1097669005277 heme binding site [chemical binding]; other site 1097669005278 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 1097669005279 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1097669005280 metal binding site 2 [ion binding]; metal-binding site 1097669005281 putative DNA binding helix; other site 1097669005282 metal binding site 1 [ion binding]; metal-binding site 1097669005283 dimer interface [polypeptide binding]; other site 1097669005284 structural Zn2+ binding site [ion binding]; other site 1097669005285 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1097669005286 substrate binding site [chemical binding]; other site 1097669005287 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1097669005288 substrate binding site [chemical binding]; other site 1097669005289 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1097669005290 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR3; cd08275 1097669005291 putative NAD(P) binding site [chemical binding]; other site 1097669005292 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1097669005293 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1097669005294 tetramer interface [polypeptide binding]; other site 1097669005295 active site 1097669005296 Mg2+/Mn2+ binding site [ion binding]; other site 1097669005297 Isocitrate lyase [Energy production and conversion]; Region: AceA; COG2224 1097669005298 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1097669005299 PPE family; Region: PPE; pfam00823 1097669005300 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1097669005301 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1097669005302 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1097669005303 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1097669005304 PPE family; Region: PPE; pfam00823 1097669005305 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1097669005306 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1097669005307 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 1097669005308 putative hydrophobic ligand binding site [chemical binding]; other site 1097669005309 protein interface [polypeptide binding]; other site 1097669005310 gate; other site 1097669005311 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1097669005312 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 1097669005313 putative acyl-acceptor binding pocket; other site 1097669005314 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1097669005315 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1097669005316 Beta-lactamase; Region: Beta-lactamase; pfam00144 1097669005317 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1097669005318 Beta-lactamase; Region: Beta-lactamase; pfam00144 1097669005319 putative fatty-acid--CoA ligase; Provisional; Region: PRK12476 1097669005320 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1097669005321 acyl-activating enzyme (AAE) consensus motif; other site 1097669005322 active site 1097669005323 Domain of unknown function (DUF1942); Region: DUF1942; pfam09167 1097669005324 Uncharacterized conserved protein [Function unknown]; Region: COG3361 1097669005325 short chain dehydrogenase; Provisional; Region: PRK05867 1097669005326 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1097669005327 NAD(P) binding site [chemical binding]; other site 1097669005328 active site 1097669005329 TIGR03085 family protein; Region: TIGR03085 1097669005330 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1097669005331 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1097669005332 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 1097669005333 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1097669005334 conserved cys residue [active] 1097669005335 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1097669005336 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1097669005337 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1097669005338 dimer interface [polypeptide binding]; other site 1097669005339 catalytic triad [active] 1097669005340 peroxidatic and resolving cysteines [active] 1097669005341 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1097669005342 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1097669005343 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1097669005344 active site 1097669005345 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1097669005346 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 1097669005347 FAD binding site [chemical binding]; other site 1097669005348 substrate binding site [chemical binding]; other site 1097669005349 catalytic base [active] 1097669005350 enoyl-CoA hydratase; Provisional; Region: PRK08290 1097669005351 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1097669005352 substrate binding site [chemical binding]; other site 1097669005353 oxyanion hole (OAH) forming residues; other site 1097669005354 trimer interface [polypeptide binding]; other site 1097669005355 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1097669005356 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1097669005357 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 1097669005358 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1097669005359 catalytic loop [active] 1097669005360 iron binding site [ion binding]; other site 1097669005361 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 1097669005362 FAD binding pocket [chemical binding]; other site 1097669005363 FAD binding motif [chemical binding]; other site 1097669005364 phosphate binding motif [ion binding]; other site 1097669005365 beta-alpha-beta structure motif; other site 1097669005366 NAD binding pocket [chemical binding]; other site 1097669005367 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1097669005368 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1097669005369 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1097669005370 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 1097669005371 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1097669005372 GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807 1097669005373 dimerization interface [polypeptide binding]; other site 1097669005374 active site 1097669005375 classical (c) SDR, subgroup 12; Region: SDR_c12; cd08944 1097669005376 putative NAD(P) binding site [chemical binding]; other site 1097669005377 active site 1097669005378 homodimer interface [polypeptide binding]; other site 1097669005379 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 1097669005381 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 1097669005382 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: VapC; COG1487 1097669005383 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 1097669005384 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1097669005385 non-specific DNA binding site [nucleotide binding]; other site 1097669005386 salt bridge; other site 1097669005387 sequence-specific DNA binding site [nucleotide binding]; other site 1097669005388 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 1097669005389 Uncharacterized protein family (UPF0156); Region: RHH_2; pfam03693 1097669005390 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 1097669005391 putative active site [active] 1097669005392 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1097669005393 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1097669005394 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1097669005395 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1097669005396 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1097669005397 Permease; Region: Permease; pfam02405 1097669005398 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1097669005399 Permease; Region: Permease; pfam02405 1097669005400 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1097669005401 mce related protein; Region: MCE; pfam02470 1097669005402 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1097669005403 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1097669005404 mce related protein; Region: MCE; pfam02470 1097669005405 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1097669005406 mce related protein; Region: MCE; pfam02470 1097669005407 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1097669005408 mce related protein; Region: MCE; pfam02470 1097669005409 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1097669005410 mce related protein; Region: MCE; pfam02470 1097669005411 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1097669005412 mce related protein; Region: MCE; pfam02470 1097669005413 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1097669005414 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1097669005415 YacP-like NYN domain; Region: NYN_YacP; cl01491 1097669005416 Peptidase family M48; Region: Peptidase_M48; pfam01435 1097669005417 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1097669005418 S-adenosylmethionine binding site [chemical binding]; other site 1097669005419 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1097669005420 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1097669005421 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1097669005422 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1097669005423 dimer interface [polypeptide binding]; other site 1097669005424 putative radical transfer pathway; other site 1097669005425 diiron center [ion binding]; other site 1097669005426 tyrosyl radical; other site 1097669005427 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 1097669005428 putative active site [active] 1097669005429 PE family; Region: PE; pfam00934 1097669005430 Cutinase; Region: Cutinase; pfam01083 1097669005431 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 1097669005432 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1097669005433 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1097669005434 dimerization interface [polypeptide binding]; other site 1097669005435 Lysine efflux permease [General function prediction only]; Region: COG1279 1097669005436 Cellulose binding domain; Region: CBM_2; pfam00553 1097669005437 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1097669005438 S-adenosylmethionine binding site [chemical binding]; other site 1097669005439 Uncharacterized conserved protein [Function unknown]; Region: COG5654 1097669005440 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 1097669005441 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 1097669005442 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1097669005443 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 1097669005444 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 1097669005445 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1097669005446 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1097669005447 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1097669005448 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1097669005449 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1097669005450 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1097669005451 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1097669005452 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1097669005453 tetramer interface [polypeptide binding]; other site 1097669005454 active site 1097669005455 Mg2+/Mn2+ binding site [ion binding]; other site 1097669005456 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1097669005457 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1097669005458 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 1097669005459 3beta17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 3beta-17beta-HSD_like_SDR_c; cd05341 1097669005460 homotetramer interface [polypeptide binding]; other site 1097669005461 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1097669005462 NAD binding site [chemical binding]; other site 1097669005463 homodimer interface [polypeptide binding]; other site 1097669005464 active site 1097669005465 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1097669005466 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1097669005467 S-adenosylmethionine binding site [chemical binding]; other site 1097669005468 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 1097669005469 Predicted kinase [General function prediction only]; Region: COG0645 1097669005470 AAA domain; Region: AAA_17; pfam13207 1097669005471 Universal stress protein family; Region: Usp; pfam00582 1097669005472 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1097669005473 Ligand Binding Site [chemical binding]; other site 1097669005474 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 1097669005475 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 1097669005476 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 1097669005477 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 1097669005478 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1097669005479 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1097669005480 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 1097669005481 Ferredoxin [Energy production and conversion]; Region: COG1146 1097669005482 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1097669005483 AAA domain; Region: AAA_14; pfam13173 1097669005484 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 1097669005485 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 1097669005486 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 1097669005487 putative active site [active] 1097669005488 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1097669005489 MarR family; Region: MarR_2; pfam12802 1097669005490 Phage envelope protein [General function prediction only]; Region: COG5562 1097669005491 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1097669005492 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1097669005493 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1097669005494 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1097669005495 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1097669005496 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1097669005497 active site 1097669005498 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1097669005499 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1097669005500 non-specific DNA binding site [nucleotide binding]; other site 1097669005501 salt bridge; other site 1097669005502 sequence-specific DNA binding site [nucleotide binding]; other site 1097669005503 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 1097669005504 Uncharacterized conserved protein [Function unknown]; Region: COG2442 1097669005505 Predicted helicase [General function prediction only]; Region: COG4889 1097669005506 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1097669005507 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1097669005508 non-specific DNA binding site [nucleotide binding]; other site 1097669005509 salt bridge; other site 1097669005510 sequence-specific DNA binding site [nucleotide binding]; other site 1097669005511 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4683 1097669005512 pseudo 1097669005513 Predicted helicase [General function prediction only]; Region: COG4889 1097669005514 Restriction endonuclease; Region: Mrr_cat_2; pfam13156 1097669005515 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 1097669005516 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1097669005517 ATP binding site [chemical binding]; other site 1097669005518 putative Mg++ binding site [ion binding]; other site 1097669005519 Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271 1097669005520 ATP-binding site [chemical binding]; other site 1097669005521 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1097669005522 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1097669005523 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1097669005524 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1097669005525 Ligand Binding Site [chemical binding]; other site 1097669005526 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1097669005527 Ligand Binding Site [chemical binding]; other site 1097669005528 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1097669005529 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1097669005530 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1097669005531 Histidine kinase; Region: HisKA_3; pfam07730 1097669005532 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1097669005533 Ligand Binding Site [chemical binding]; other site 1097669005534 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1097669005535 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1097669005536 putative substrate binding site [chemical binding]; other site 1097669005537 putative ATP binding site [chemical binding]; other site 1097669005538 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1097669005539 active site 1097669005540 Erythromycin esterase homolog [General function prediction only]; Region: COG2312 1097669005541 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1097669005542 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1097669005543 putative dimer interface [polypeptide binding]; other site 1097669005544 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1097669005545 dimer interface [polypeptide binding]; other site 1097669005546 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 1097669005547 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1097669005548 putative DNA binding site [nucleotide binding]; other site 1097669005549 dimerization interface [polypeptide binding]; other site 1097669005550 putative Zn2+ binding site [ion binding]; other site 1097669005551 Ligand-binding SRPBCC domain of Micromonospora echinospora CalC and related proteins; Region: SRPBCC_CalC; cd08891 1097669005552 putative hydrophobic ligand binding site [chemical binding]; other site 1097669005553 CLM binding site; other site 1097669005554 L1 loop; other site 1097669005555 DNA binding site [nucleotide binding] 1097669005556 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1097669005557 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1097669005558 MDMPI C-terminal domain; Region: MDMPI_C; pfam07398 1097669005559 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1097669005560 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 1097669005561 nucleophile elbow; other site 1097669005562 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1097669005563 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1097669005564 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1097669005565 Walker A/P-loop; other site 1097669005566 ATP binding site [chemical binding]; other site 1097669005567 Q-loop/lid; other site 1097669005568 ABC transporter signature motif; other site 1097669005569 Walker B; other site 1097669005570 D-loop; other site 1097669005571 H-loop/switch region; other site 1097669005572 TOBE domain; Region: TOBE_2; pfam08402 1097669005573 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1097669005574 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1097669005575 dimer interface [polypeptide binding]; other site 1097669005576 conserved gate region; other site 1097669005577 putative PBP binding loops; other site 1097669005578 ABC-ATPase subunit interface; other site 1097669005579 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1097669005580 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1097669005581 dimer interface [polypeptide binding]; other site 1097669005582 conserved gate region; other site 1097669005583 putative PBP binding loops; other site 1097669005584 ABC-ATPase subunit interface; other site 1097669005585 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1097669005586 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1097669005587 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 1097669005588 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 1097669005589 Isochorismatase family; Region: Isochorismatase; pfam00857 1097669005590 catalytic triad [active] 1097669005591 metal binding site [ion binding]; metal-binding site 1097669005592 conserved cis-peptide bond; other site 1097669005593 Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861 1097669005594 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1097669005595 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1097669005596 substrate binding pocket [chemical binding]; other site 1097669005597 catalytic triad [active] 1097669005598 hypothetical protein; Provisional; Region: PRK05865 1097669005599 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1097669005600 NAD(P) binding site [chemical binding]; other site 1097669005601 active site 1097669005602 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1097669005603 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 1097669005604 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 1097669005605 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1097669005606 putative active site [active] 1097669005607 catalytic triad [active] 1097669005608 putative dimer interface [polypeptide binding]; other site 1097669005609 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 1097669005610 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 1097669005611 Ligand binding site; other site 1097669005612 Putative Catalytic site; other site 1097669005613 DXD motif; other site 1097669005614 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1097669005615 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1097669005616 active site 1097669005617 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 1097669005618 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1097669005619 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 1097669005620 30S ribosomal protein S18; Provisional; Region: PRK13401 1097669005621 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1097669005622 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1097669005623 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1097669005624 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1097669005625 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1097669005626 intersubunit interface [polypeptide binding]; other site 1097669005627 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1097669005628 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1097669005629 PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666 1097669005630 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 1097669005631 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1097669005632 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1097669005633 precorrin-3B synthase; Region: CobG; TIGR02435 1097669005634 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1097669005635 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 1097669005636 Precorrin-8X methylmutase; Region: CbiC; pfam02570 1097669005637 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 1097669005638 active site 1097669005639 SAM binding site [chemical binding]; other site 1097669005640 homodimer interface [polypeptide binding]; other site 1097669005641 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 1097669005642 active site 1097669005643 SAM binding site [chemical binding]; other site 1097669005644 homodimer interface [polypeptide binding]; other site 1097669005645 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1097669005646 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1097669005647 S-adenosylmethionine binding site [chemical binding]; other site 1097669005648 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 1097669005649 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1097669005650 RNA polymerase sigma factor SigC; Reviewed; Region: PRK09649 1097669005651 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1097669005652 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1097669005653 DNA binding residues [nucleotide binding] 1097669005654 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 1097669005655 precorrin-6x reductase; Region: precor6x_red; TIGR00715 1097669005656 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 1097669005657 active site 1097669005658 SAM binding site [chemical binding]; other site 1097669005659 homodimer interface [polypeptide binding]; other site 1097669005660 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 1097669005661 active site 1097669005662 putative homodimer interface [polypeptide binding]; other site 1097669005663 SAM binding site [chemical binding]; other site 1097669005664 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 1097669005665 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1097669005666 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1097669005667 NAD(P) binding site [chemical binding]; other site 1097669005668 active site 1097669005669 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1097669005670 Catalytic domain of uncharacterized Mycobacterium tuberculosis Rv2075c-like proteins; Region: PI-PLCc_Rv2075c_like; cd08590 1097669005671 putative active site [active] 1097669005672 catalytic site [active] 1097669005673 putative metal binding site [ion binding]; other site 1097669005674 C-type lectin (CTL)/C-type lectin-like (CTLD) domain; Region: CLECT; cl02432 1097669005675 Protein of unknown function (DUF2563); Region: DUF2563; pfam10817 1097669005676 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 1097669005677 putative transposase OrfB; Reviewed; Region: PHA02517 1097669005678 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1097669005679 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1097669005680 active site 1097669005681 ATP binding site [chemical binding]; other site 1097669005682 substrate binding site [chemical binding]; other site 1097669005683 activation loop (A-loop); other site 1097669005684 PknH-like extracellular domain; Region: PknH_C; pfam14032 1097669005685 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1097669005686 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1097669005687 active site 1097669005688 5'-3' exonuclease, N-terminal resolvase-like domain; Region: 5_3_exonuc_N; pfam02739 1097669005689 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1097669005690 active site 1097669005691 metal binding site 1 [ion binding]; metal-binding site 1097669005692 putative 5' ssDNA interaction site; other site 1097669005693 metal binding site 3; metal-binding site 1097669005694 metal binding site 2 [ion binding]; metal-binding site 1097669005695 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1097669005696 putative DNA binding site [nucleotide binding]; other site 1097669005697 putative metal binding site [ion binding]; other site 1097669005698 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 1097669005699 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 1097669005700 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1097669005701 ATP binding site [chemical binding]; other site 1097669005702 putative Mg++ binding site [ion binding]; other site 1097669005703 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1097669005704 nucleotide binding region [chemical binding]; other site 1097669005705 ATP-binding site [chemical binding]; other site 1097669005706 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 1097669005707 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 1097669005708 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 1097669005709 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 1097669005710 Predicted transcriptional regulator [Transcription]; Region: COG2378 1097669005711 WYL domain; Region: WYL; pfam13280 1097669005712 Predicted transcriptional regulator [Transcription]; Region: COG2378 1097669005713 WYL domain; Region: WYL; pfam13280 1097669005714 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 1097669005715 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1097669005716 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1097669005717 active site 1097669005718 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 1097669005719 SNF2 Helicase protein; Region: DUF3670; pfam12419 1097669005720 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1097669005721 ATP binding site [chemical binding]; other site 1097669005722 putative Mg++ binding site [ion binding]; other site 1097669005723 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1097669005724 nucleotide binding region [chemical binding]; other site 1097669005725 ATP-binding site [chemical binding]; other site 1097669005726 Uncharacterized conserved protein [Function unknown]; Region: COG4279 1097669005727 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 1097669005728 putative active site [active] 1097669005729 PE family; Region: PE; pfam00934 1097669005730 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1097669005731 PPE family; Region: PPE; pfam00823 1097669005732 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 1097669005733 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 1097669005734 active site 1097669005735 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 1097669005736 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 1097669005737 active site 1097669005738 Pup-like protein; Region: Pup; pfam05639 1097669005739 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 1097669005740 proteasome ATPase; Region: pup_AAA; TIGR03689 1097669005741 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1097669005742 Walker A motif; other site 1097669005743 ATP binding site [chemical binding]; other site 1097669005744 Walker B motif; other site 1097669005745 arginine finger; other site 1097669005746 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1097669005747 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1550 1097669005748 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 1097669005749 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1097669005750 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 1097669005751 Predicted membrane protein [Function unknown]; Region: COG3918 1097669005752 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 1097669005753 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 1097669005754 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 1097669005755 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 1097669005756 homodimer interface [polypeptide binding]; other site 1097669005757 putative metal binding site [ion binding]; other site 1097669005758 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1097669005759 PPE family; Region: PPE; pfam00823 1097669005760 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1097669005761 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 1097669005762 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 1097669005763 substrate binding pocket [chemical binding]; other site 1097669005764 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 1097669005765 B12 binding site [chemical binding]; other site 1097669005766 cobalt ligand [ion binding]; other site 1097669005767 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 1097669005768 PAC2 family; Region: PAC2; pfam09754 1097669005769 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1097669005770 short chain dehydrogenase; Provisional; Region: PRK05872 1097669005771 classical (c) SDRs; Region: SDR_c; cd05233 1097669005772 NAD(P) binding site [chemical binding]; other site 1097669005773 active site 1097669005774 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1097669005775 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 1097669005776 active site 1097669005777 HIGH motif; other site 1097669005778 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1097669005779 active site 1097669005780 KMSKS motif; other site 1097669005781 Anticodon-binding domain of cysteinyl tRNA synthetases and domain found in MshC; Region: Anticodon_Ia_Cys_like; cd07955 1097669005782 putative tRNA binding surface [nucleotide binding]; other site 1097669005783 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1097669005784 active site 1097669005785 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1097669005786 conserved hypothetical protein; Region: TIGR03843 1097669005787 conserved hypothetical protein; Region: TIGR03847 1097669005788 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1097669005789 catalytic core [active] 1097669005790 undecaprenyl-diphosphatase UppP; Region: undec_PP_bacA; TIGR00753 1097669005791 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1097669005792 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1097669005793 quinone interaction residues [chemical binding]; other site 1097669005794 active site 1097669005795 catalytic residues [active] 1097669005796 FMN binding site [chemical binding]; other site 1097669005797 substrate binding site [chemical binding]; other site 1097669005798 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1097669005799 substrate binding site [chemical binding]; other site 1097669005800 hypothetical protein; Provisional; Region: PRK07906 1097669005801 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 1097669005802 putative metal binding site [ion binding]; other site 1097669005803 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483 1097669005804 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1097669005805 active site 1097669005806 DivIVA domain; Region: DivI1A_domain; TIGR03544 1097669005807 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 1097669005808 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1097669005809 Predicted integral membrane protein [Function unknown]; Region: COG0762 1097669005810 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 1097669005811 Predicted enzyme with a TIM-barrel fold [General function prediction only]; Region: COG0325 1097669005812 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1097669005813 catalytic residue [active] 1097669005814 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1097669005815 uncharacterized protein, YfiH family; Region: TIGR00726 1097669005816 cell division protein FtsZ; Validated; Region: PRK09330 1097669005817 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1097669005818 nucleotide binding site [chemical binding]; other site 1097669005819 SulA interaction site; other site 1097669005820 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 1097669005821 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1097669005822 Cell division protein FtsQ; Region: FtsQ; pfam03799 1097669005823 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1097669005824 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1097669005825 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1097669005826 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1097669005827 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1097669005828 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Region: murG; TIGR01133 1097669005829 active site 1097669005830 homodimer interface [polypeptide binding]; other site 1097669005831 cell division protein FtsW; Region: ftsW; TIGR02614 1097669005832 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03369 1097669005833 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1097669005834 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1097669005835 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1097669005836 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1097669005837 Mg++ binding site [ion binding]; other site 1097669005838 putative catalytic motif [active] 1097669005839 putative substrate binding site [chemical binding]; other site 1097669005840 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 1097669005841 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1097669005842 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1097669005843 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1097669005844 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1097669005845 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1097669005846 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1097669005847 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1097669005848 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1097669005849 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1097669005850 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1097669005851 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1097669005852 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1097669005853 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1097669005854 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1097669005855 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 1097669005856 MraW methylase family; Region: Methyltransf_5; pfam01795 1097669005857 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 1097669005858 MraZ protein; Region: MraZ; pfam02381 1097669005859 MraZ protein; Region: MraZ; pfam02381 1097669005860 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 1097669005861 Protein of unknown function (DUF3153); Region: DUF3153; pfam11353 1097669005862 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1097669005863 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1097669005864 substrate binding pocket [chemical binding]; other site 1097669005865 chain length determination region; other site 1097669005866 substrate-Mg2+ binding site; other site 1097669005867 catalytic residues [active] 1097669005868 aspartate-rich region 1; other site 1097669005869 active site lid residues [active] 1097669005870 aspartate-rich region 2; other site 1097669005871 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 1097669005872 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1097669005873 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1097669005874 active site 1097669005875 ATP binding site [chemical binding]; other site 1097669005876 substrate binding site [chemical binding]; other site 1097669005877 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1097669005878 substrate binding site [chemical binding]; other site 1097669005879 activation loop (A-loop); other site 1097669005880 activation loop (A-loop); other site 1097669005881 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; COG3200 1097669005882 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 1097669005883 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1097669005884 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1097669005885 putative acyl-acceptor binding pocket; other site 1097669005886 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 1097669005887 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1097669005888 DTAP/Switch II; other site 1097669005889 Switch I; other site 1097669005890 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1097669005891 putative hydrophobic ligand binding site [chemical binding]; other site 1097669005892 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1097669005893 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1097669005894 acyl-activating enzyme (AAE) consensus motif; other site 1097669005895 putative AMP binding site [chemical binding]; other site 1097669005896 putative active site [active] 1097669005897 putative CoA binding site [chemical binding]; other site 1097669005898 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1097669005899 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1097669005900 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 1097669005901 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1097669005902 NlpC/P60 family; Region: NLPC_P60; pfam00877 1097669005903 hypothetical protein; Validated; Region: PRK07883 1097669005904 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1097669005905 active site 1097669005906 catalytic site [active] 1097669005907 substrate binding site [chemical binding]; other site 1097669005908 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1097669005909 GIY-YIG motif/motif A; other site 1097669005910 active site 1097669005911 catalytic site [active] 1097669005912 putative DNA binding site [nucleotide binding]; other site 1097669005913 metal binding site [ion binding]; metal-binding site 1097669005914 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1097669005915 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1097669005916 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1097669005917 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 1097669005918 Subunit I/III interface [polypeptide binding]; other site 1097669005919 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1097669005920 Cytochrome c; Region: Cytochrom_C; pfam00034 1097669005921 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1097669005922 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1097669005923 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1097669005924 iron-sulfur cluster [ion binding]; other site 1097669005925 [2Fe-2S] cluster binding site [ion binding]; other site 1097669005926 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1097669005927 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 1097669005928 heme bH binding site [chemical binding]; other site 1097669005929 intrachain domain interface; other site 1097669005930 heme bL binding site [chemical binding]; other site 1097669005931 interchain domain interface [polypeptide binding]; other site 1097669005932 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 1097669005933 Qo binding site; other site 1097669005934 Protein of unknown function (DUF2561); Region: DUF2561; pfam10812 1097669005935 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1097669005936 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 1097669005937 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 1097669005938 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1097669005939 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 1097669005940 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1097669005941 dimer interface [polypeptide binding]; other site 1097669005942 active site 1097669005943 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1097669005944 Ligand Binding Site [chemical binding]; other site 1097669005945 Molecular Tunnel; other site 1097669005946 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 1097669005947 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1097669005948 substrate binding site [chemical binding]; other site 1097669005949 ATP binding site [chemical binding]; other site 1097669005950 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1097669005951 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 1097669005952 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 1097669005953 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 1097669005954 putative dimer interface [polypeptide binding]; other site 1097669005955 active site pocket [active] 1097669005956 putative cataytic base [active] 1097669005957 Cobalamin-5-phosphate synthase; Region: CobS; pfam02654 1097669005958 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1097669005959 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1097669005960 homodimer interface [polypeptide binding]; other site 1097669005961 substrate-cofactor binding pocket; other site 1097669005962 catalytic residue [active] 1097669005963 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1097669005964 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1097669005965 cyclase homology domain; Region: CHD; cd07302 1097669005966 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1097669005967 nucleotidyl binding site; other site 1097669005968 metal binding site [ion binding]; metal-binding site 1097669005969 dimer interface [polypeptide binding]; other site 1097669005970 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1097669005971 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1097669005972 interface (dimer of trimers) [polypeptide binding]; other site 1097669005973 Substrate-binding/catalytic site; other site 1097669005974 Zn-binding sites [ion binding]; other site 1097669005975 short chain dehydrogenase; Validated; Region: PRK05855 1097669005976 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1097669005977 classical (c) SDRs; Region: SDR_c; cd05233 1097669005978 NAD(P) binding site [chemical binding]; other site 1097669005979 active site 1097669005980 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 1097669005981 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1097669005982 E3 interaction surface; other site 1097669005983 lipoyl attachment site [posttranslational modification]; other site 1097669005984 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1097669005985 E3 interaction surface; other site 1097669005986 lipoyl attachment site [posttranslational modification]; other site 1097669005987 e3 binding domain; Region: E3_binding; pfam02817 1097669005988 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1097669005989 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 1097669005990 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 1097669005991 putative NAD(P) binding site [chemical binding]; other site 1097669005992 putative active site [active] 1097669005993 lipoate-protein ligase B; Provisional; Region: PRK14345 1097669005994 lipoyl synthase; Provisional; Region: PRK05481 1097669005995 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1097669005996 FeS/SAM binding site; other site 1097669005997 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 1097669005998 RDD family; Region: RDD; pfam06271 1097669005999 glutamine synthetase, type I; Region: GlnA; TIGR00653 1097669006000 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1097669006001 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1097669006002 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 1097669006003 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1097669006004 metal binding triad; other site 1097669006005 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1097669006006 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1097669006007 metal binding triad; other site 1097669006008 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1097669006009 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1097669006010 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1097669006011 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1097669006012 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1097669006013 TAP-like protein; Region: Abhydrolase_4; pfam08386 1097669006014 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1097669006015 TAP-like protein; Region: Abhydrolase_4; pfam08386 1097669006016 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1097669006017 oligomerization interface [polypeptide binding]; other site 1097669006018 active site 1097669006019 metal binding site [ion binding]; metal-binding site 1097669006020 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 1097669006021 putative active site; other site 1097669006022 putative metal binding residues [ion binding]; other site 1097669006023 signature motif; other site 1097669006024 putative triphosphate binding site [ion binding]; other site 1097669006025 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 1097669006026 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3826 1097669006027 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 1097669006028 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1097669006029 RNA/DNA hybrid binding site [nucleotide binding]; other site 1097669006030 active site 1097669006031 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1097669006032 catalytic core [active] 1097669006033 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 1097669006034 Putative zinc ribbon domain; Region: DUF164; pfam02591 1097669006035 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 1097669006036 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 1097669006037 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1097669006038 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1097669006039 hypothetical protein; Provisional; Region: PRK07908 1097669006040 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1097669006041 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1097669006042 homodimer interface [polypeptide binding]; other site 1097669006043 catalytic residue [active] 1097669006044 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1097669006045 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1097669006046 active site 1097669006047 motif I; other site 1097669006048 motif II; other site 1097669006049 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1097669006050 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1097669006051 active site 1097669006052 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 1097669006053 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 1097669006054 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 1097669006055 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1097669006056 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 1097669006057 dimer interface [polypeptide binding]; other site 1097669006058 catalytic triad [active] 1097669006059 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 1097669006060 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 1097669006061 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1097669006062 dimer interface [polypeptide binding]; other site 1097669006063 TPP-binding site [chemical binding]; other site 1097669006064 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1097669006065 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1097669006066 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1097669006067 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1097669006068 acyl carrier protein; Provisional; Region: acpP; PRK00982 1097669006069 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 1097669006070 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1097669006071 dimer interface [polypeptide binding]; other site 1097669006072 active site 1097669006073 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 1097669006074 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1097669006075 dimer interface [polypeptide binding]; other site 1097669006076 active site 1097669006077 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1097669006078 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1097669006079 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1097669006080 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1097669006081 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1097669006082 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1097669006083 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1097669006084 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1097669006085 FAD binding domain; Region: FAD_binding_4; pfam01565 1097669006086 diacylglycerol kinase; Reviewed; Region: PRK11914 1097669006087 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1097669006089 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 1097669006090 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1097669006091 Beta-lactamase; Region: Beta-lactamase; pfam00144 1097669006092 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1097669006093 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1097669006094 S-adenosylmethionine binding site [chemical binding]; other site 1097669006095 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 1097669006096 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1097669006097 NAD binding site [chemical binding]; other site 1097669006098 catalytic Zn binding site [ion binding]; other site 1097669006099 substrate binding site [chemical binding]; other site 1097669006100 structural Zn binding site [ion binding]; other site 1097669006101 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1097669006102 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 1097669006103 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1097669006104 putative active site [active] 1097669006105 catalytic triad [active] 1097669006106 putative dimer interface [polypeptide binding]; other site 1097669006107 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 1097669006108 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 1097669006109 active site 1097669006110 dimer interface [polypeptide binding]; other site 1097669006111 short chain dehydrogenase; Provisional; Region: PRK05854 1097669006112 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 1097669006113 putative NAD(P) binding site [chemical binding]; other site 1097669006114 active site 1097669006115 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 1097669006116 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1097669006117 nucleotide binding site [chemical binding]; other site 1097669006118 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1097669006119 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1097669006120 Cytochrome P450; Region: p450; cl12078 1097669006121 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 1097669006122 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1097669006123 Cytochrome P450; Region: p450; cl12078 1097669006124 Septum formation; Region: Septum_form; pfam13845 1097669006125 Protein of unknown function (DUF2695); Region: DUF2695; pfam10905 1097669006126 Predicted membrane protein [Function unknown]; Region: COG2149 1097669006127 Domain of unknown function (DUF202); Region: DUF202; pfam02656 1097669006128 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1097669006129 Cytochrome P450; Region: p450; cl12078 1097669006130 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial protein Rv2277c and similar proteins; Region: GDPD_Rv2277c_like; cd08580 1097669006131 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 1097669006132 putative active site [active] 1097669006133 catalytic site [active] 1097669006134 putative metal binding site [ion binding]; other site 1097669006135 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 1097669006136 FAD binding domain; Region: FAD_binding_4; pfam01565 1097669006137 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1097669006138 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1097669006139 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1097669006140 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1097669006141 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1097669006142 dimerization interface [polypeptide binding]; other site 1097669006143 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1097669006144 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1097669006145 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1097669006146 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1097669006147 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1097669006148 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1097669006149 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1097669006150 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 1097669006151 CDP-diacylglycerol pyrophosphatase [Lipid metabolism]; Region: Cdh; COG2134 1097669006152 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1097669006153 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1097669006154 active site residue [active] 1097669006155 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1097669006156 active site residue [active] 1097669006157 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1097669006158 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 1097669006159 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1097669006160 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1097669006161 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1097669006162 homodimer interface [polypeptide binding]; other site 1097669006163 catalytic residue [active] 1097669006164 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3196 1097669006165 haloalkane dehalogenase; Provisional; Region: PRK00870 1097669006166 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1097669006167 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1097669006168 active site 1097669006169 catalytic tetrad [active] 1097669006170 heat shock protein 90; Provisional; Region: PRK05218 1097669006171 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1097669006172 ATP binding site [chemical binding]; other site 1097669006173 Mg2+ binding site [ion binding]; other site 1097669006174 G-X-G motif; other site 1097669006175 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1097669006176 Cutinase; Region: Cutinase; pfam01083 1097669006177 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 1097669006178 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 1097669006179 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 1097669006180 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1097669006181 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1097669006182 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1097669006183 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1097669006184 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1097669006185 Uncharacterized conserved protein [Function unknown]; Region: COG2442 1097669006186 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1097669006187 DNA binding site [nucleotide binding] 1097669006188 active site 1097669006189 Int/Topo IB signature motif; other site 1097669006190 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 1097669006191 DNA binding residues [nucleotide binding] 1097669006192 Family description; Region: UvrD_C_2; pfam13538 1097669006193 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1097669006194 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1097669006195 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1097669006196 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1097669006197 putative PBP binding loops; other site 1097669006198 ABC-ATPase subunit interface; other site 1097669006199 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1097669006200 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1097669006201 dimer interface [polypeptide binding]; other site 1097669006202 conserved gate region; other site 1097669006203 putative PBP binding loops; other site 1097669006204 ABC-ATPase subunit interface; other site 1097669006205 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1097669006206 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1097669006207 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1097669006208 Ligand Binding Site [chemical binding]; other site 1097669006209 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1097669006210 Ligand Binding Site [chemical binding]; other site 1097669006211 amino acid transporter; Region: 2A0306; TIGR00909 1097669006212 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1097669006213 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 1097669006214 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1097669006215 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1097669006216 catalytic residue [active] 1097669006217 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1097669006218 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1097669006219 Amidinotransferase; Region: Amidinotransf; pfam02274 1097669006220 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 1097669006221 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1097669006222 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1097669006223 putative DNA binding site [nucleotide binding]; other site 1097669006224 putative Zn2+ binding site [ion binding]; other site 1097669006225 AsnC family; Region: AsnC_trans_reg; pfam01037 1097669006226 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1097669006227 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1097669006228 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 1097669006229 Walker A/P-loop; other site 1097669006230 ATP binding site [chemical binding]; other site 1097669006231 Q-loop/lid; other site 1097669006232 ABC transporter signature motif; other site 1097669006233 Walker B; other site 1097669006234 D-loop; other site 1097669006235 H-loop/switch region; other site 1097669006236 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1097669006237 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1097669006238 Walker A/P-loop; other site 1097669006239 ATP binding site [chemical binding]; other site 1097669006240 Q-loop/lid; other site 1097669006241 ABC transporter signature motif; other site 1097669006242 Walker B; other site 1097669006243 D-loop; other site 1097669006244 H-loop/switch region; other site 1097669006245 MarR family; Region: MarR; pfam01047 1097669006246 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1097669006247 PE family; Region: PE; pfam00934 1097669006248 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1097669006249 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1097669006250 putative substrate translocation pore; other site 1097669006251 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 1097669006252 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1097669006253 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1097669006254 malate dehydrogenase; Provisional; Region: PRK13529 1097669006255 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1097669006256 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1097669006257 NAD(P) binding site [chemical binding]; other site 1097669006258 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1097669006259 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1097669006260 putative substrate translocation pore; other site 1097669006261 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1097669006262 putative substrate translocation pore; other site 1097669006263 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1097669006264 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1097669006265 dimer interface [polypeptide binding]; other site 1097669006266 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1097669006267 catalytic residue [active] 1097669006268 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 1097669006269 serine O-acetyltransferase; Region: cysE; TIGR01172 1097669006270 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1097669006271 trimer interface [polypeptide binding]; other site 1097669006272 active site 1097669006273 substrate binding site [chemical binding]; other site 1097669006274 CoA binding site [chemical binding]; other site 1097669006275 hypothetical protein; Provisional; Region: PRK14851 1097669006276 hypothetical protein; Validated; Region: PRK08223 1097669006277 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 1097669006278 ATP binding site [chemical binding]; other site 1097669006279 substrate interface [chemical binding]; other site 1097669006280 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1097669006281 PE family; Region: PE; pfam00934 1097669006282 DNA primase; Validated; Region: dnaG; PRK05667 1097669006283 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1097669006284 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1097669006285 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1097669006286 active site 1097669006287 metal binding site [ion binding]; metal-binding site 1097669006288 interdomain interaction site; other site 1097669006289 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1097669006290 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 1097669006291 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 1097669006292 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1097669006293 Zn2+ binding site [ion binding]; other site 1097669006294 Mg2+ binding site [ion binding]; other site 1097669006295 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1097669006296 Repair protein; Region: Repair_PSII; pfam04536 1097669006297 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1097669006298 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1097669006299 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 1097669006300 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1097669006301 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 1097669006302 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1097669006303 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 1097669006304 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1097669006305 glycyl-tRNA synthetase; Provisional; Region: PRK04173 1097669006306 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1097669006307 motif 1; other site 1097669006308 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 1097669006309 active site 1097669006310 motif 2; other site 1097669006311 motif 3; other site 1097669006312 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 1097669006313 anticodon binding site; other site 1097669006314 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1097669006315 dimerization interface [polypeptide binding]; other site 1097669006316 putative DNA binding site [nucleotide binding]; other site 1097669006317 putative Zn2+ binding site [ion binding]; other site 1097669006318 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1097669006319 metal binding site 2 [ion binding]; metal-binding site 1097669006320 putative DNA binding helix; other site 1097669006321 metal binding site 1 [ion binding]; metal-binding site 1097669006322 dimer interface [polypeptide binding]; other site 1097669006323 structural Zn2+ binding site [ion binding]; other site 1097669006324 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1097669006325 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1097669006326 catalytic residue [active] 1097669006327 putative FPP diphosphate binding site; other site 1097669006328 putative FPP binding hydrophobic cleft; other site 1097669006329 dimer interface [polypeptide binding]; other site 1097669006330 putative IPP diphosphate binding site; other site 1097669006331 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1097669006332 Recombination protein O N terminal; Region: RecO_N; pfam11967 1097669006333 Recombination protein O C terminal; Region: RecO_C; pfam02565 1097669006334 amidase; Provisional; Region: PRK06061 1097669006335 Amidase; Region: Amidase; pfam01425 1097669006336 GTPase Era; Reviewed; Region: era; PRK00089 1097669006337 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1097669006338 G1 box; other site 1097669006339 GTP/Mg2+ binding site [chemical binding]; other site 1097669006340 Switch I region; other site 1097669006341 G2 box; other site 1097669006342 Switch II region; other site 1097669006343 G3 box; other site 1097669006344 G4 box; other site 1097669006345 G5 box; other site 1097669006346 KH domain; Region: KH_2; pfam07650 1097669006347 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1097669006348 Domain of unknown function DUF21; Region: DUF21; pfam01595 1097669006349 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1097669006350 Transporter associated domain; Region: CorC_HlyC; smart01091 1097669006351 metal-binding heat shock protein; Provisional; Region: PRK00016 1097669006352 K homology RNA-binding domain; Region: KH; smart00322 1097669006353 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1097669006354 PhoH-like protein; Region: PhoH; pfam02562 1097669006355 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1097669006356 PE family; Region: PE; pfam00934 1097669006357 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 1097669006358 RNA methyltransferase, RsmE family; Region: TIGR00046 1097669006359 chaperone protein DnaJ; Provisional; Region: PRK14278 1097669006360 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1097669006361 HSP70 interaction site [polypeptide binding]; other site 1097669006362 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1097669006363 Zn binding sites [ion binding]; other site 1097669006364 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1097669006365 dimer interface [polypeptide binding]; other site 1097669006366 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1097669006367 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 1097669006368 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 1097669006369 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1097669006370 Condensation domain; Region: Condensation; pfam00668 1097669006371 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1097669006372 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1097669006373 acyl-activating enzyme (AAE) consensus motif; other site 1097669006374 AMP binding site [chemical binding]; other site 1097669006375 Condensation domain; Region: Condensation; pfam00668 1097669006376 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1097669006377 Condensation domain; Region: Condensation; pfam00668 1097669006378 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1097669006379 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1097669006380 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1097669006381 acyl-activating enzyme (AAE) consensus motif; other site 1097669006382 AMP binding site [chemical binding]; other site 1097669006383 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1097669006384 Condensation domain; Region: Condensation; pfam00668 1097669006385 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1097669006386 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1097669006387 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1097669006388 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1097669006389 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1097669006390 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1097669006391 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 1097669006392 NADP binding site [chemical binding]; other site 1097669006393 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1097669006394 active site 1097669006395 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1097669006396 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1097669006397 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1097669006398 active site 1097669006399 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 1097669006400 Condensation domain; Region: Condensation; pfam00668 1097669006401 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1097669006402 Nonribosomal peptide synthase; Region: NRPS; pfam08415 1097669006403 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 1097669006404 acyl-activating enzyme (AAE) consensus motif; other site 1097669006405 AMP binding site [chemical binding]; other site 1097669006406 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1097669006407 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1097669006408 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 1097669006409 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 1097669006410 acyl-activating enzyme (AAE) consensus motif; other site 1097669006411 active site 1097669006412 AMP binding site [chemical binding]; other site 1097669006413 substrate binding site [chemical binding]; other site 1097669006414 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1097669006415 salicylate synthase MbtI; Reviewed; Region: PRK07912 1097669006416 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1097669006417 Predicted permease [General function prediction only]; Region: COG3329 1097669006418 coproporphyrinogen III oxidase; Validated; Region: PRK05628 1097669006419 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1097669006420 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 1097669006421 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1097669006422 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1097669006423 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1097669006424 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1097669006425 Active Sites [active] 1097669006426 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1097669006427 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1097669006428 putative active site [active] 1097669006429 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 1097669006430 putative active site [active] 1097669006431 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1097669006432 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1097669006433 Predicted membrane protein [Function unknown]; Region: COG1297 1097669006434 putative oligopeptide transporter, OPT family; Region: TIGR00733 1097669006435 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 1097669006436 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 1097669006437 Walker A/P-loop; other site 1097669006438 ATP binding site [chemical binding]; other site 1097669006439 Q-loop/lid; other site 1097669006440 ABC transporter signature motif; other site 1097669006441 Walker B; other site 1097669006442 D-loop; other site 1097669006443 H-loop/switch region; other site 1097669006444 sulfate transport protein; Provisional; Region: cysT; CHL00187 1097669006445 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1097669006446 dimer interface [polypeptide binding]; other site 1097669006447 conserved gate region; other site 1097669006448 putative PBP binding loops; other site 1097669006449 ABC-ATPase subunit interface; other site 1097669006450 sulfate transport protein; Provisional; Region: cysT; CHL00187 1097669006451 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1097669006452 dimer interface [polypeptide binding]; other site 1097669006453 conserved gate region; other site 1097669006454 putative PBP binding loops; other site 1097669006455 ABC-ATPase subunit interface; other site 1097669006456 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 1097669006457 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1097669006458 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 1097669006459 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1097669006460 PknH-like extracellular domain; Region: PknH_C; pfam14032 1097669006461 GTP-binding protein LepA; Provisional; Region: PRK05433 1097669006462 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1097669006463 G1 box; other site 1097669006464 putative GEF interaction site [polypeptide binding]; other site 1097669006465 GTP/Mg2+ binding site [chemical binding]; other site 1097669006466 Switch I region; other site 1097669006467 G2 box; other site 1097669006468 G3 box; other site 1097669006469 Switch II region; other site 1097669006470 G4 box; other site 1097669006471 G5 box; other site 1097669006472 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1097669006473 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1097669006474 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1097669006475 PemK-like protein; Region: PemK; pfam02452 1097669006476 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 1097669006477 FOG: CBS domain [General function prediction only]; Region: COG0517 1097669006478 ribonuclease Z; Reviewed; Region: PRK00055 1097669006479 PE family; Region: PE; pfam00934 1097669006480 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1097669006481 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1097669006482 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1097669006483 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 1097669006484 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 1097669006485 Uncharacterized conserved protein [Function unknown]; Region: COG2308 1097669006486 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1097669006487 hypothetical protein; Reviewed; Region: PRK07914 1097669006488 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1097669006489 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 1097669006490 Competence protein; Region: Competence; pfam03772 1097669006491 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 1097669006492 Helix-hairpin-helix motif; Region: HHH; pfam00633 1097669006493 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 1097669006494 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1097669006495 Coenzyme A binding pocket [chemical binding]; other site 1097669006496 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307 1097669006497 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1097669006498 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1097669006499 active site 1097669006500 catalytic triad [active] 1097669006501 oxyanion hole [active] 1097669006502 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1097669006503 catalytic core [active] 1097669006504 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 1097669006505 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1097669006506 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1097669006507 active site 1097669006508 (T/H)XGH motif; other site 1097669006509 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1097669006510 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1097669006511 S-adenosylmethionine binding site [chemical binding]; other site 1097669006512 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 1097669006513 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1097669006514 metal ion-dependent adhesion site (MIDAS); other site 1097669006515 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1097669006516 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1097669006517 Walker A motif; other site 1097669006518 ATP binding site [chemical binding]; other site 1097669006519 Walker B motif; other site 1097669006520 arginine finger; other site 1097669006521 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1097669006522 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1097669006523 putative catalytic cysteine [active] 1097669006524 pseudo 1097669006525 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1097669006526 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1097669006527 dimer interface [polypeptide binding]; other site 1097669006528 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1097669006529 catalytic triad [active] 1097669006530 peroxidatic and resolving cysteines [active] 1097669006531 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 1097669006532 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 1097669006533 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1097669006534 PPE family; Region: PPE; pfam00823 1097669006535 PE family; Region: PE; pfam00934 1097669006536 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1097669006537 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1097669006538 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1097669006539 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1097669006540 ligand binding site [chemical binding]; other site 1097669006541 flexible hinge region; other site 1097669006542 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1097669006543 dimerization interface [polypeptide binding]; other site 1097669006544 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 1097669006545 cyclase homology domain; Region: CHD; cd07302 1097669006546 nucleotidyl binding site; other site 1097669006547 metal binding site [ion binding]; metal-binding site 1097669006548 dimer interface [polypeptide binding]; other site 1097669006549 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1097669006550 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1097669006551 substrate binding site [chemical binding]; other site 1097669006552 dimer interface [polypeptide binding]; other site 1097669006553 ATP binding site [chemical binding]; other site 1097669006554 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1097669006555 NAD synthetase; Reviewed; Region: nadE; PRK02628 1097669006556 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 1097669006557 multimer interface [polypeptide binding]; other site 1097669006558 active site 1097669006559 catalytic triad [active] 1097669006560 protein interface 1 [polypeptide binding]; other site 1097669006561 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1097669006562 homodimer interface [polypeptide binding]; other site 1097669006563 NAD binding pocket [chemical binding]; other site 1097669006564 ATP binding pocket [chemical binding]; other site 1097669006565 Mg binding site [ion binding]; other site 1097669006566 active-site loop [active] 1097669006567 gamma-glutamyl kinase; Provisional; Region: PRK05429 1097669006568 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1097669006569 nucleotide binding site [chemical binding]; other site 1097669006570 homotetrameric interface [polypeptide binding]; other site 1097669006571 putative phosphate binding site [ion binding]; other site 1097669006572 putative allosteric binding site; other site 1097669006573 PUA domain; Region: PUA; pfam01472 1097669006574 GTPase CgtA; Reviewed; Region: obgE; PRK12296 1097669006575 GTP1/OBG; Region: GTP1_OBG; pfam01018 1097669006576 Obg GTPase; Region: Obg; cd01898 1097669006577 G1 box; other site 1097669006578 GTP/Mg2+ binding site [chemical binding]; other site 1097669006579 Switch I region; other site 1097669006580 G2 box; other site 1097669006581 G3 box; other site 1097669006582 Switch II region; other site 1097669006583 G4 box; other site 1097669006584 G5 box; other site 1097669006585 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1097669006586 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1097669006587 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1097669006588 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1097669006589 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1097669006590 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 1097669006591 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1097669006592 homodimer interface [polypeptide binding]; other site 1097669006593 oligonucleotide binding site [chemical binding]; other site 1097669006594 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1097669006595 active site 1097669006596 multimer interface [polypeptide binding]; other site 1097669006597 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 1097669006598 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1097669006599 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1097669006600 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1097669006601 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1097669006602 active site 1097669006603 HIGH motif; other site 1097669006604 nucleotide binding site [chemical binding]; other site 1097669006605 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1097669006606 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1097669006607 active site 1097669006608 KMSKS motif; other site 1097669006609 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1097669006610 tRNA binding surface [nucleotide binding]; other site 1097669006611 anticodon binding site; other site 1097669006612 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1097669006613 Uncharacterized conserved protein [Function unknown]; Region: COG3268 1097669006614 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 1097669006615 NAD(P) binding pocket [chemical binding]; other site 1097669006616 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1097669006617 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1097669006618 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1097669006619 GTP binding site; other site 1097669006620 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 1097669006621 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 1097669006622 TPP-binding site [chemical binding]; other site 1097669006623 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1097669006624 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 1097669006625 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1097669006626 dimer interface [polypeptide binding]; other site 1097669006627 PYR/PP interface [polypeptide binding]; other site 1097669006628 TPP binding site [chemical binding]; other site 1097669006629 substrate binding site [chemical binding]; other site 1097669006630 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1097669006631 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1097669006632 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1097669006633 Walker A motif; other site 1097669006634 ATP binding site [chemical binding]; other site 1097669006635 Walker B motif; other site 1097669006636 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1097669006637 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 1097669006638 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 1097669006639 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1097669006640 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1097669006641 putative substrate translocation pore; other site 1097669006642 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1097669006643 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 1097669006644 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1097669006645 oligomer interface [polypeptide binding]; other site 1097669006646 active site residues [active] 1097669006647 Clp protease; Region: CLP_protease; pfam00574 1097669006648 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1097669006649 oligomer interface [polypeptide binding]; other site 1097669006650 active site residues [active] 1097669006651 trigger factor; Provisional; Region: tig; PRK01490 1097669006652 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1097669006653 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1097669006654 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1097669006655 Beta-lactamase; Region: Beta-lactamase; pfam00144 1097669006656 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1097669006657 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 1097669006658 putative DNA binding site [nucleotide binding]; other site 1097669006659 catalytic residue [active] 1097669006660 putative H2TH interface [polypeptide binding]; other site 1097669006661 putative catalytic residues [active] 1097669006662 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1097669006663 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1097669006664 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 1097669006665 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1097669006666 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1097669006667 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 1097669006668 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 1097669006669 Zn binding site [ion binding]; other site 1097669006670 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1097669006671 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1097669006672 active site 1097669006673 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1097669006674 apolar tunnel; other site 1097669006675 heme binding site [chemical binding]; other site 1097669006676 dimerization interface [polypeptide binding]; other site 1097669006677 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 1097669006678 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1097669006679 active site 1097669006680 catalytic site [active] 1097669006681 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1097669006682 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1097669006683 active site 1097669006684 NAD-specific glutamate dehydrogenase [Amino acid transport and metabolism]; Region: COG2902 1097669006685 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1097669006686 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1097669006687 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1097669006688 ABC transporter; Region: ABC_tran_2; pfam12848 1097669006689 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1097669006690 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1097669006691 dimer interface [polypeptide binding]; other site 1097669006692 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1097669006693 ssDNA binding site [nucleotide binding]; other site 1097669006694 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1097669006695 glycerol-3-phosphate acyltransferase; Validated; Region: PRK03355 1097669006696 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 1097669006697 putative acyl-acceptor binding pocket; other site 1097669006698 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1097669006699 HAD-superfamily subfamily IB hydrolase, TIGR01490; Region: HAD-SF-IB-hyp1 1097669006700 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1097669006701 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1097669006702 putative acyl-acceptor binding pocket; other site 1097669006703 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1097669006704 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1097669006705 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1097669006706 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1097669006707 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1097669006708 enoyl-CoA hydratase; Provisional; Region: PRK05870 1097669006709 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1097669006710 substrate binding site [chemical binding]; other site 1097669006711 oxyanion hole (OAH) forming residues; other site 1097669006712 trimer interface [polypeptide binding]; other site 1097669006713 PE family; Region: PE; pfam00934 1097669006714 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1097669006715 cyclase homology domain; Region: CHD; cd07302 1097669006716 nucleotidyl binding site; other site 1097669006717 metal binding site [ion binding]; metal-binding site 1097669006718 dimer interface [polypeptide binding]; other site 1097669006719 Predicted ATPase [General function prediction only]; Region: COG3903 1097669006720 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1097669006721 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1097669006722 DNA binding residues [nucleotide binding] 1097669006723 dimerization interface [polypeptide binding]; other site 1097669006724 TIGR00725 family protein; Region: TIGR00725 1097669006725 thymidylate synthase; Provisional; Region: thyA; PRK00956 1097669006726 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 1097669006727 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1097669006728 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1097669006729 E3 interaction surface; other site 1097669006730 lipoyl attachment site [posttranslational modification]; other site 1097669006731 e3 binding domain; Region: E3_binding; pfam02817 1097669006732 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1097669006733 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1097669006734 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1097669006735 alpha subunit interface [polypeptide binding]; other site 1097669006736 TPP binding site [chemical binding]; other site 1097669006737 heterodimer interface [polypeptide binding]; other site 1097669006738 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1097669006739 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1097669006740 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1097669006741 tetramer interface [polypeptide binding]; other site 1097669006742 TPP-binding site [chemical binding]; other site 1097669006743 heterodimer interface [polypeptide binding]; other site 1097669006744 phosphorylation loop region [posttranslational modification] 1097669006745 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1097669006746 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 1097669006747 putative active site [active] 1097669006748 putative catalytic site [active] 1097669006749 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1097669006750 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1097669006751 active site 1097669006752 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1097669006753 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1097669006754 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1097669006755 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1097669006756 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1097669006757 carboxyltransferase (CT) interaction site; other site 1097669006758 biotinylation site [posttranslational modification]; other site 1097669006759 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1097669006760 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1097669006761 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1097669006762 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1097669006763 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1097669006764 AMP-binding domain protein; Validated; Region: PRK08315 1097669006765 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1097669006766 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 1097669006767 acyl-activating enzyme (AAE) consensus motif; other site 1097669006768 acyl-activating enzyme (AAE) consensus motif; other site 1097669006769 putative AMP binding site [chemical binding]; other site 1097669006770 putative active site [active] 1097669006771 putative CoA binding site [chemical binding]; other site 1097669006772 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1097669006773 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1097669006774 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 1097669006775 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1097669006776 classical (c) SDRs; Region: SDR_c; cd05233 1097669006777 NAD(P) binding site [chemical binding]; other site 1097669006778 active site 1097669006779 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 1097669006780 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 1097669006781 catalytic site [active] 1097669006782 putative active site [active] 1097669006783 putative substrate binding site [chemical binding]; other site 1097669006784 dimer interface [polypeptide binding]; other site 1097669006785 Domain of unknown function (DUF4411); Region: DUF4411; pfam14367 1097669006786 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1097669006787 non-specific DNA binding site [nucleotide binding]; other site 1097669006788 salt bridge; other site 1097669006789 sequence-specific DNA binding site [nucleotide binding]; other site 1097669006790 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 1097669006791 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2739; cl17893 1097669006792 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 1097669006793 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 1097669006794 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1097669006795 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1097669006796 PE family; Region: PE; pfam00934 1097669006797 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 1097669006798 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1097669006799 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1097669006800 catalytic triad [active] 1097669006801 hypothetical protein; Provisional; Region: PRK07907 1097669006802 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 1097669006803 active site 1097669006804 metal binding site [ion binding]; metal-binding site 1097669006805 dimer interface [polypeptide binding]; other site 1097669006806 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1097669006807 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1097669006808 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 1097669006809 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1097669006810 phosphate binding site [ion binding]; other site 1097669006811 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 1097669006812 FAS_MaoC, the MaoC-like hot dog fold of the fatty acid synthase, beta subunit. Other enzymes with this fold include MaoC dehydratase, Hydratase-Dehydrogenase-Epimerase protein (HDE), and 17-beta-hydroxysteriod dehydrogenase (HSD); Region: FAS_MaoC; cd03447 1097669006813 putative active site [active] 1097669006814 putative catalytic site [active] 1097669006815 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1097669006816 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1097669006817 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 1097669006818 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 1097669006819 putative NAD(P) binding site [chemical binding]; other site 1097669006820 active site 1097669006821 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 1097669006822 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1097669006823 active site 1097669006824 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 1097669006825 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 1097669006826 putative active site [active] 1097669006827 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 1097669006828 Mrr N-terminal domain; Region: Mrr_N; pfam14338 1097669006829 Restriction endonuclease; Region: Mrr_cat; pfam04471 1097669006830 ERCC4 domain; Region: ERCC4; pfam02732 1097669006831 Lsr2; Region: Lsr2; pfam11774 1097669006832 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 1097669006833 putative active site [active] 1097669006834 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1097669006835 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1097669006836 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1097669006837 catalytic residue [active] 1097669006838 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1097669006839 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 1097669006840 putative RNA binding site [nucleotide binding]; other site 1097669006841 elongation factor P; Validated; Region: PRK00529 1097669006842 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1097669006843 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1097669006844 RNA binding site [nucleotide binding]; other site 1097669006845 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1097669006846 RNA binding site [nucleotide binding]; other site 1097669006847 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1097669006848 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1097669006849 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1097669006850 active site 1097669006851 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1097669006852 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1097669006853 trimer interface [polypeptide binding]; other site 1097669006854 active site 1097669006855 dimer interface [polypeptide binding]; other site 1097669006856 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1097669006857 active site 1097669006858 dimer interface [polypeptide binding]; other site 1097669006859 metal binding site [ion binding]; metal-binding site 1097669006860 shikimate kinase; Reviewed; Region: aroK; PRK00131 1097669006861 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1097669006862 ADP binding site [chemical binding]; other site 1097669006863 magnesium binding site [ion binding]; other site 1097669006864 putative shikimate binding site; other site 1097669006865 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1097669006866 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1097669006867 Tetramer interface [polypeptide binding]; other site 1097669006868 active site 1097669006869 FMN-binding site [chemical binding]; other site 1097669006870 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 1097669006871 digalactosyldiacylglycerol synthase; Region: PLN02846 1097669006872 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 1097669006873 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 1097669006874 putative active site [active] 1097669006875 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1097669006876 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1097669006877 oligomeric interface; other site 1097669006878 putative active site [active] 1097669006879 homodimer interface [polypeptide binding]; other site 1097669006880 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2402 1097669006881 putative active site [active] 1097669006882 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1097669006883 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1097669006884 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1097669006885 shikimate-5-dehydrogenase, fungal AROM-type; Region: Shik-DH-AROM; TIGR01809 1097669006886 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1097669006887 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1097669006888 NAD(P) binding site [chemical binding]; other site 1097669006889 shikimate binding site; other site 1097669006890 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 1097669006891 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1097669006892 dimerization interface [polypeptide binding]; other site 1097669006893 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1097669006894 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1097669006895 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1097669006896 motif 1; other site 1097669006897 active site 1097669006898 motif 2; other site 1097669006899 motif 3; other site 1097669006900 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1097669006901 DHHA1 domain; Region: DHHA1; pfam02272 1097669006902 Uncharacterized conserved protein [Function unknown]; Region: COG0432 1097669006903 recombination factor protein RarA; Reviewed; Region: PRK13342 1097669006904 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1097669006905 Walker A motif; other site 1097669006906 ATP binding site [chemical binding]; other site 1097669006907 Walker B motif; other site 1097669006908 arginine finger; other site 1097669006909 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1097669006910 Predicted integral membrane protein [Function unknown]; Region: COG5473 1097669006911 Protein of unknown function (DUF2652); Region: DUF2652; pfam10851 1097669006912 Protein of unknown function (DUF2652); Region: DUF2652; pfam10851 1097669006913 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1097669006914 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1097669006915 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1097669006916 Walker A/P-loop; other site 1097669006917 ATP binding site [chemical binding]; other site 1097669006918 Q-loop/lid; other site 1097669006919 ABC transporter signature motif; other site 1097669006920 Walker B; other site 1097669006921 D-loop; other site 1097669006922 H-loop/switch region; other site 1097669006923 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1097669006924 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1097669006925 ligand binding site [chemical binding]; other site 1097669006926 flexible hinge region; other site 1097669006927 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1097669006928 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1097669006929 ligand binding site [chemical binding]; other site 1097669006930 flexible hinge region; other site 1097669006931 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1097669006932 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 1097669006933 active site 1097669006934 nucleophile elbow; other site 1097669006935 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1097669006936 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1097669006937 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1097669006938 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 1097669006939 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 1097669006940 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307 1097669006941 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 1097669006942 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1097669006943 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1097669006944 Transglutaminase/protease-like homologues; Region: TGc; smart00460 1097669006945 Protein of unknown function (DUF419); Region: DUF419; cl15265 1097669006946 Predicted membrane protein [Function unknown]; Region: COG4129 1097669006947 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1097669006948 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1097669006949 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1097669006950 dimer interface [polypeptide binding]; other site 1097669006951 anticodon binding site; other site 1097669006952 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1097669006953 homodimer interface [polypeptide binding]; other site 1097669006954 motif 1; other site 1097669006955 active site 1097669006956 motif 2; other site 1097669006957 GAD domain; Region: GAD; pfam02938 1097669006958 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1097669006959 active site 1097669006960 motif 3; other site 1097669006961 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 1097669006962 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1097669006963 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1097669006964 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 1097669006965 putative hydrophobic ligand binding site [chemical binding]; other site 1097669006966 protein interface [polypeptide binding]; other site 1097669006967 gate; other site 1097669006968 Predicted metalloprotease [General function prediction only]; Region: COG2321 1097669006969 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1097669006970 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 1097669006971 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1097669006972 active site 1097669006973 metal binding site [ion binding]; metal-binding site 1097669006974 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 1097669006975 haloalkane dehalogenase; Provisional; Region: PRK03592 1097669006976 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1097669006977 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1097669006978 dimer interface [polypeptide binding]; other site 1097669006979 motif 1; other site 1097669006980 active site 1097669006981 motif 2; other site 1097669006982 motif 3; other site 1097669006983 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1097669006984 anticodon binding site; other site 1097669006985 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1097669006986 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1097669006987 active site 1097669006988 (p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691 1097669006989 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1097669006990 Zn2+ binding site [ion binding]; other site 1097669006991 Mg2+ binding site [ion binding]; other site 1097669006992 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1097669006993 synthetase active site [active] 1097669006994 NTP binding site [chemical binding]; other site 1097669006995 metal binding site [ion binding]; metal-binding site 1097669006996 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1097669006997 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1097669006998 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1097669006999 active site 1097669007000 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1097669007001 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1097669007002 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1097669007003 Protein export membrane protein; Region: SecD_SecF; pfam02355 1097669007004 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 1097669007005 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1097669007006 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05886 1097669007007 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 1097669007008 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1097669007009 inhibitor-cofactor binding pocket; inhibition site 1097669007010 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1097669007011 catalytic residue [active] 1097669007012 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1097669007013 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1097669007014 acyl-activating enzyme (AAE) consensus motif; other site 1097669007015 AMP binding site [chemical binding]; other site 1097669007016 active site 1097669007017 CoA binding site [chemical binding]; other site 1097669007018 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 1097669007019 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 1097669007020 putative NAD(P) binding site [chemical binding]; other site 1097669007021 active site 1097669007022 putative substrate binding site [chemical binding]; other site 1097669007023 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1097669007024 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1097669007025 Walker A motif; other site 1097669007026 ATP binding site [chemical binding]; other site 1097669007027 Walker B motif; other site 1097669007028 arginine finger; other site 1097669007029 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1097669007030 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1097669007031 RuvA N terminal domain; Region: RuvA_N; pfam01330 1097669007032 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1097669007033 active site 1097669007034 putative DNA-binding cleft [nucleotide binding]; other site 1097669007035 dimer interface [polypeptide binding]; other site 1097669007036 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1097669007037 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 1097669007038 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 1097669007039 putative active site [active] 1097669007040 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 1097669007041 Protein of unknown function DUF2617; Region: DUF2617; pfam10936 1097669007042 Domain of unknown function (DUF4247); Region: DUF4247; pfam14042 1097669007043 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1097669007044 Predicted spermidine synthase with an N-terminal membrane domain [General function prediction only]; Region: COG4262 1097669007045 Spermine/spermidine synthase; Region: Spermine_synth; pfam01564 1097669007046 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 1097669007047 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 1097669007048 hypothetical protein; Validated; Region: PRK00110 1097669007049 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 1097669007050 predicted active site [active] 1097669007051 catalytic triad [active] 1097669007052 acyl-CoA thioesterase II; Region: tesB; TIGR00189 1097669007053 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1097669007054 active site 1097669007055 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1097669007056 catalytic triad [active] 1097669007057 dimer interface [polypeptide binding]; other site 1097669007058 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 1097669007059 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 1097669007060 active site 1097669007061 multimer interface [polypeptide binding]; other site 1097669007062 Pyridoxamine-phosphate oxidase [Coenzyme metabolism]; Region: PdxH; COG0259 1097669007063 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1097669007064 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 1097669007065 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1097669007066 PPE family; Region: PPE; pfam00823 1097669007067 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1097669007068 PE-PPE domain; Region: PE-PPE; pfam08237 1097669007069 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_26; cd04685 1097669007070 nudix motif; other site 1097669007071 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1097669007072 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1097669007073 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1097669007074 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1097669007075 putative acyl-acceptor binding pocket; other site 1097669007076 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1097669007077 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 1097669007078 nucleotide binding site/active site [active] 1097669007079 HIT family signature motif; other site 1097669007080 catalytic residue [active] 1097669007081 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 1097669007082 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1097669007083 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1097669007084 active site 1097669007085 dimer interface [polypeptide binding]; other site 1097669007086 motif 1; other site 1097669007087 motif 2; other site 1097669007088 motif 3; other site 1097669007089 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1097669007090 anticodon binding site; other site 1097669007091 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1097669007092 phosphate binding site [ion binding]; other site 1097669007093 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4762 1097669007094 Predicted transcriptional regulator [Transcription]; Region: COG2345 1097669007095 Helix-turn-helix domain; Region: HTH_20; pfam12840 1097669007096 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1097669007097 Predicted transcriptional regulator [Transcription]; Region: COG2345 1097669007098 Helix-turn-helix domain; Region: HTH_20; pfam12840 1097669007099 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1097669007100 S-adenosylmethionine binding site [chemical binding]; other site 1097669007101 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1097669007102 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1097669007103 Ligand Binding Site [chemical binding]; other site 1097669007104 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1097669007105 Ligand Binding Site [chemical binding]; other site 1097669007106 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1097669007107 Ligand Binding Site [chemical binding]; other site 1097669007108 Universal stress protein family; Region: Usp; pfam00582 1097669007109 Ligand Binding Site [chemical binding]; other site 1097669007110 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 1097669007111 active site 1097669007112 Peptidase family M50; Region: Peptidase_M50; pfam02163 1097669007113 putative substrate binding region [chemical binding]; other site 1097669007114 FOG: CBS domain [General function prediction only]; Region: COG0517 1097669007115 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612 1097669007116 FOG: CBS domain [General function prediction only]; Region: COG0517 1097669007117 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 1097669007118 peptide chain release factor 1; Provisional; Region: PRK04011 1097669007119 SHS2 domain protein implicated in nucleic acid metabolism [General function prediction only]; Region: COG1371 1097669007120 Uncharacterized conserved protein [Function unknown]; Region: RtcB; COG1690 1097669007121 hypothetical protein; Reviewed; Region: PRK09588 1097669007122 Domain of unknown function (DUF1876); Region: DUF1876; pfam08962 1097669007123 Hemerythrin-like domain; Region: Hr-like; cd12108 1097669007124 Fe binding site [ion binding]; other site 1097669007125 Chloramphenicol (Cm) phosphotransferase (CPT). Cm-inactivating enzyme; modifies the primary (C-3) hydroxyl of the antibiotic. Related structurally to shikimate kinase II; Region: CPT; cd00227 1097669007126 P-loop motif; other site 1097669007127 ATP binding site [chemical binding]; other site 1097669007128 Chloramphenicol (Cm) binding site [chemical binding]; other site 1097669007129 catalytic residue [active] 1097669007130 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1097669007131 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1097669007132 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1097669007133 anti sigma factor interaction site; other site 1097669007134 regulatory phosphorylation site [posttranslational modification]; other site 1097669007135 hypothetical protein; Provisional; Region: PRK02237 1097669007136 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1097669007137 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1097669007138 putative DNA binding site [nucleotide binding]; other site 1097669007139 putative Zn2+ binding site [ion binding]; other site 1097669007140 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 1097669007141 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1097669007142 putative metal binding site [ion binding]; other site 1097669007143 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1097669007144 dimerization interface [polypeptide binding]; other site 1097669007145 putative DNA binding site [nucleotide binding]; other site 1097669007146 putative Zn2+ binding site [ion binding]; other site 1097669007147 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 1097669007148 arsenical-resistance protein; Region: acr3; TIGR00832 1097669007149 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1097669007150 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1097669007151 active site 1097669007152 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1097669007153 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1097669007154 active site 1097669007155 DNA binding site [nucleotide binding] 1097669007156 Int/Topo IB signature motif; other site 1097669007157 Predicted phage phi-C31 gp36 major capsid-like protein [General function prediction only]; Region: COG4653 1097669007158 Phage capsid family; Region: Phage_capsid; pfam05065 1097669007159 Phage head maturation protease [General function prediction only]; Region: COG3740 1097669007160 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: COG3747 1097669007161 Protein of unknown function (DUF3631); Region: DUF3631; pfam12307 1097669007162 Protein of unknown function (DUF2742); Region: DUF2742; pfam10888 1097669007163 DNA binding domain, excisionase family; Region: excise; TIGR01764 1097669007164 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1097669007165 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1097669007166 active site 1097669007167 catalytic residues [active] 1097669007168 DNA binding site [nucleotide binding] 1097669007169 Int/Topo IB signature motif; other site 1097669007170 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1097669007171 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1097669007172 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1097669007173 Coenzyme A binding pocket [chemical binding]; other site 1097669007174 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 1097669007175 hypothetical protein; Provisional; Region: PRK14059 1097669007176 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 1097669007177 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1097669007178 TAP-like protein; Region: Abhydrolase_4; pfam08386 1097669007179 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 1097669007180 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 1097669007181 SelR domain; Region: SelR; pfam01641 1097669007182 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1097669007183 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1097669007184 S-adenosylmethionine binding site [chemical binding]; other site 1097669007185 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 1097669007186 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 1097669007187 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1097669007188 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1097669007189 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1097669007190 substrate binding site [chemical binding]; other site 1097669007191 active site 1097669007192 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1097669007193 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1097669007194 substrate binding site [chemical binding]; other site 1097669007195 oxyanion hole (OAH) forming residues; other site 1097669007196 trimer interface [polypeptide binding]; other site 1097669007197 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 1097669007198 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 1097669007199 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1097669007200 catalytic site [active] 1097669007201 putative active site [active] 1097669007202 putative substrate binding site [chemical binding]; other site 1097669007203 Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154 1097669007204 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1097669007205 TPP-binding site; other site 1097669007206 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1097669007207 PYR/PP interface [polypeptide binding]; other site 1097669007208 dimer interface [polypeptide binding]; other site 1097669007209 TPP binding site [chemical binding]; other site 1097669007210 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1097669007211 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1097669007212 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1097669007213 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 1097669007214 transmembrane helices; other site 1097669007215 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1097669007216 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 1097669007217 transmembrane helices; other site 1097669007218 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1097669007219 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1097669007220 Walker A/P-loop; other site 1097669007221 ATP binding site [chemical binding]; other site 1097669007222 Q-loop/lid; other site 1097669007223 ABC transporter signature motif; other site 1097669007224 Walker B; other site 1097669007225 D-loop; other site 1097669007226 H-loop/switch region; other site 1097669007227 TRAM domain; Region: TRAM; cl01282 1097669007228 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1097669007229 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1097669007230 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1097669007231 TrkA-N domain; Region: TrkA_N; pfam02254 1097669007232 TrkA-C domain; Region: TrkA_C; pfam02080 1097669007233 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1097669007234 TrkA-N domain; Region: TrkA_N; pfam02254 1097669007235 TrkA-C domain; Region: TrkA_C; pfam02080 1097669007236 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 1097669007237 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1097669007238 generic binding surface II; other site 1097669007239 ssDNA binding site; other site 1097669007240 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 1097669007241 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1097669007242 trimer interface [polypeptide binding]; other site 1097669007243 active site 1097669007244 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 1097669007245 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 1097669007246 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1097669007247 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1097669007248 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 1097669007249 active site 1097669007250 dimerization interface [polypeptide binding]; other site 1097669007251 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1097669007252 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1097669007253 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 1097669007254 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1097669007255 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1097669007256 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1097669007257 DNA binding residues [nucleotide binding] 1097669007258 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 1097669007259 homotrimer interaction site [polypeptide binding]; other site 1097669007260 putative active site [active] 1097669007261 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3502 1097669007262 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 1097669007263 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 1097669007264 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 1097669007265 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 1097669007266 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1097669007267 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1097669007268 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1097669007269 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1097669007270 DNA binding residues [nucleotide binding] 1097669007271 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 1097669007272 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1097669007273 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1097669007274 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 1097669007275 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 1097669007276 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 1097669007277 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1097669007278 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1097669007279 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1097669007280 PAC2 family; Region: PAC2; pfam09754 1097669007281 Phenazine biosynthesis-like protein; Region: PhzC-PhzF; pfam02567 1097669007282 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 1097669007283 heme-binding site [chemical binding]; other site 1097669007284 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1097669007285 ATP cone domain; Region: ATP-cone; pfam03477 1097669007286 LysM domain; Region: LysM; pfam01476 1097669007287 LexA repressor; Validated; Region: PRK00215 1097669007288 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1097669007289 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1097669007290 Catalytic site [active] 1097669007291 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 1097669007292 LGFP repeat; Region: LGFP; pfam08310 1097669007293 LGFP repeat; Region: LGFP; pfam08310 1097669007294 LGFP repeat; Region: LGFP; pfam08310 1097669007295 LGFP repeat; Region: LGFP; pfam08310 1097669007296 LGFP repeat; Region: LGFP; pfam08310 1097669007297 Integral membrane protein TerC family; Region: TerC; cl10468 1097669007298 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1097669007299 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1097669007300 active site 1097669007301 GTPases [General function prediction only]; Region: HflX; COG2262 1097669007302 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1097669007303 HflX GTPase family; Region: HflX; cd01878 1097669007304 G1 box; other site 1097669007305 GTP/Mg2+ binding site [chemical binding]; other site 1097669007306 Switch I region; other site 1097669007307 G2 box; other site 1097669007308 G3 box; other site 1097669007309 Switch II region; other site 1097669007310 G4 box; other site 1097669007311 G5 box; other site 1097669007312 diaminopimelate epimerase; Region: DapF; TIGR00652 1097669007313 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1097669007314 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1097669007315 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1097669007316 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1097669007317 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 1097669007318 active site 1097669007319 metal binding site [ion binding]; metal-binding site 1097669007320 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1097669007321 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1097669007322 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1097669007323 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 1097669007324 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1097669007325 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1097669007326 FeS/SAM binding site; other site 1097669007327 TRAM domain; Region: TRAM; cl01282 1097669007328 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1097669007329 FeS/SAM binding site; other site 1097669007330 Uncharacterized protein conserved in bacteria [General function prediction only]; Region: OraA; COG2137 1097669007331 DNA recombination protein RecA; Reviewed; Region: recA; PRK09519 1097669007332 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1097669007333 hexamer interface [polypeptide binding]; other site 1097669007334 Walker A motif; other site 1097669007335 ATP binding site [chemical binding]; other site 1097669007336 Walker B motif; other site 1097669007337 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1097669007338 protein-splicing catalytic site; other site 1097669007339 thioester formation/cholesterol transfer; other site 1097669007340 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 1097669007341 recA bacterial DNA recombination protein; Region: RecA; cl17211 1097669007342 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 1097669007343 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 1097669007344 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1097669007345 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1097669007346 Limonene-1,2-epoxide hydrolase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LimA; COG4308 1097669007347 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 1097669007348 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1097669007349 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1097669007350 non-specific DNA binding site [nucleotide binding]; other site 1097669007351 salt bridge; other site 1097669007352 sequence-specific DNA binding site [nucleotide binding]; other site 1097669007353 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1097669007354 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1097669007355 Coenzyme A binding pocket [chemical binding]; other site 1097669007356 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1097669007357 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1097669007358 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 1097669007359 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1097669007360 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 1097669007361 classical (c) SDRs; Region: SDR_c; cd05233 1097669007362 NAD(P) binding site [chemical binding]; other site 1097669007363 active site 1097669007364 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1097669007365 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1097669007366 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1097669007367 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1097669007368 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1097669007369 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1097669007370 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1097669007371 dimer interface [polypeptide binding]; other site 1097669007372 active site 1097669007373 catalytic residue [active] 1097669007374 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 1097669007375 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1097669007376 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1097669007377 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 1097669007378 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1097669007379 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 1097669007380 putative active site [active] 1097669007381 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 1097669007382 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 1097669007383 putative active site [active] 1097669007384 Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704 1097669007385 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1097669007386 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1097669007387 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 1097669007388 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1097669007389 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1097669007390 folate binding site [chemical binding]; other site 1097669007391 NADP+ binding site [chemical binding]; other site 1097669007392 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1097669007393 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1097669007394 dimerization interface [polypeptide binding]; other site 1097669007395 active site 1097669007396 Dienelactone hydrolase family; Region: DLH; pfam01738 1097669007397 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 1097669007398 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1097669007399 classical (c) SDRs; Region: SDR_c; cd05233 1097669007400 NAD(P) binding site [chemical binding]; other site 1097669007401 active site 1097669007402 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1097669007403 PPE family; Region: PPE; pfam00823 1097669007404 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1097669007405 PE family; Region: PE; pfam00934 1097669007406 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1097669007407 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1097669007408 PPE family; Region: PPE; pfam00823 1097669007409 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1097669007410 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1097669007411 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1097669007412 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1097669007413 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1097669007414 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1097669007415 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1097669007416 Coenzyme A binding pocket [chemical binding]; other site 1097669007417 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1097669007418 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 1097669007419 FMN-binding pocket [chemical binding]; other site 1097669007420 flavin binding motif; other site 1097669007421 phosphate binding motif [ion binding]; other site 1097669007422 beta-alpha-beta structure motif; other site 1097669007423 NAD binding pocket [chemical binding]; other site 1097669007424 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1097669007425 catalytic loop [active] 1097669007426 iron binding site [ion binding]; other site 1097669007427 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 1097669007428 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 1097669007429 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1097669007430 hydrophobic ligand binding site; other site 1097669007431 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1097669007432 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1097669007433 putative DNA binding site [nucleotide binding]; other site 1097669007434 putative Zn2+ binding site [ion binding]; other site 1097669007435 AsnC family; Region: AsnC_trans_reg; pfam01037 1097669007436 alanine dehydrogenase; Region: alaDH; TIGR00518 1097669007437 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1097669007438 hexamer interface [polypeptide binding]; other site 1097669007439 ligand binding site [chemical binding]; other site 1097669007440 putative active site [active] 1097669007441 NAD(P) binding site [chemical binding]; other site 1097669007442 Nitronate monooxygenase; Region: NMO; pfam03060 1097669007443 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1097669007444 FMN binding site [chemical binding]; other site 1097669007445 substrate binding site [chemical binding]; other site 1097669007446 putative catalytic residue [active] 1097669007447 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1097669007448 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1097669007449 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1097669007450 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 1097669007451 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 1097669007452 oligomer interface [polypeptide binding]; other site 1097669007453 RNA binding site [nucleotide binding]; other site 1097669007454 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1097669007455 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1097669007456 RNase E interface [polypeptide binding]; other site 1097669007457 trimer interface [polypeptide binding]; other site 1097669007458 active site 1097669007459 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1097669007460 putative nucleic acid binding region [nucleotide binding]; other site 1097669007461 G-X-X-G motif; other site 1097669007462 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1097669007463 RNA binding site [nucleotide binding]; other site 1097669007464 domain interface; other site 1097669007465 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1097669007466 16S/18S rRNA binding site [nucleotide binding]; other site 1097669007467 S13e-L30e interaction site [polypeptide binding]; other site 1097669007468 25S rRNA binding site [nucleotide binding]; other site 1097669007469 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1097669007470 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1097669007471 active site 1097669007472 Riboflavin kinase; Region: Flavokinase; pfam01687 1097669007473 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1097669007474 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 1097669007475 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 1097669007476 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1097669007477 putative DNA binding site [nucleotide binding]; other site 1097669007478 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1097669007479 FeoA domain; Region: FeoA; pfam04023 1097669007480 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1097669007481 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1097669007482 active site 1097669007483 lipid-transfer protein; Provisional; Region: PRK08256 1097669007484 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1097669007485 active site 1097669007486 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1097669007487 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1097669007488 Probable transposase; Region: OrfB_IS605; pfam01385 1097669007489 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 1097669007490 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 1097669007491 catalytic residues [active] 1097669007492 catalytic nucleophile [active] 1097669007493 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 1097669007494 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1097669007495 RNA binding site [nucleotide binding]; other site 1097669007496 active site 1097669007497 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 1097669007498 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 1097669007499 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1097669007500 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 1097669007501 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1097669007502 active site 1097669007503 metal binding site [ion binding]; metal-binding site 1097669007504 Uncharacterized conserved protein [Function unknown]; Region: COG4717 1097669007505 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 1097669007506 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 1097669007507 Predicted acyl esterases [General function prediction only]; Region: COG2936 1097669007508 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 1097669007509 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 1097669007510 Uncharacterized conserved protein [Function unknown]; Region: COG5586 1097669007511 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 1097669007512 Integrase core domain; Region: rve; pfam00665 1097669007514 Helix-turn-helix domain; Region: HTH_28; pfam13518 1097669007515 Winged helix-turn helix; Region: HTH_29; pfam13551 1097669007516 Integrase core domain; Region: rve; pfam00665 1097669007517 Integrase core domain; Region: rve_3; pfam13683 1097669007518 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 1097669007519 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 1097669007520 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638 1097669007521 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09636 1097669007522 CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cd09699 1097669007523 CRISPR/Cas system-associated RAMP superfamily protein Csm5; Region: Csm5_III-A; cd09662 1097669007524 CRISPR/Cas system-associated RAMP superfamily protein Csm4; Region: Csm4_III-A; cd09663 1097669007525 CRISPR/Cas system-associated RAMP superfamily protein Csm3; Region: Csm3_III-A; cd09684 1097669007526 CRISPR/Cas system-associated protein Csm2; Region: Csm2_III-A; cd09647 1097669007527 Predicted CRISPR-associated polymerase [Defense mechanisms]; Region: COG1353 1097669007528 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680 1097669007529 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 1097669007530 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4293 1097669007531 Uncharacterized conserved protein [Function unknown]; Region: COG2253 1097669007532 Protein of unknown function (DUF2005); Region: DUF2005; pfam09407 1097669007533 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4293 1097669007534 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 1097669007535 putative active site [active] 1097669007536 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1097669007537 enoyl-CoA hydratase; Provisional; Region: PRK06190 1097669007538 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1097669007539 substrate binding site [chemical binding]; other site 1097669007540 oxyanion hole (OAH) forming residues; other site 1097669007541 trimer interface [polypeptide binding]; other site 1097669007542 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1097669007543 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1097669007544 Walker A/P-loop; other site 1097669007545 ATP binding site [chemical binding]; other site 1097669007546 Q-loop/lid; other site 1097669007547 ABC transporter signature motif; other site 1097669007548 Walker B; other site 1097669007549 D-loop; other site 1097669007550 H-loop/switch region; other site 1097669007551 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1097669007552 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1097669007553 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1097669007554 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1097669007555 dimer interface [polypeptide binding]; other site 1097669007556 conserved gate region; other site 1097669007557 putative PBP binding loops; other site 1097669007558 ABC-ATPase subunit interface; other site 1097669007559 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1097669007560 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1097669007561 dimer interface [polypeptide binding]; other site 1097669007562 conserved gate region; other site 1097669007563 putative PBP binding loops; other site 1097669007564 ABC-ATPase subunit interface; other site 1097669007565 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1097669007566 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 1097669007567 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1097669007568 DHH family; Region: DHH; pfam01368 1097669007569 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1097669007570 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1097669007571 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1097669007572 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 1097669007573 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1097669007574 G1 box; other site 1097669007575 putative GEF interaction site [polypeptide binding]; other site 1097669007576 GTP/Mg2+ binding site [chemical binding]; other site 1097669007577 Switch I region; other site 1097669007578 G2 box; other site 1097669007579 G3 box; other site 1097669007580 Switch II region; other site 1097669007581 G4 box; other site 1097669007582 G5 box; other site 1097669007583 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1097669007584 Translation-initiation factor 2; Region: IF-2; pfam11987 1097669007585 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1097669007586 Predicted nucleic-acid-binding protein implicated in transcription termination [Transcription]; Region: COG2740 1097669007587 putative RNA binding cleft [nucleotide binding]; other site 1097669007588 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1097669007589 NusA N-terminal domain; Region: NusA_N; pfam08529 1097669007590 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1097669007591 RNA binding site [nucleotide binding]; other site 1097669007592 homodimer interface [polypeptide binding]; other site 1097669007593 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1097669007594 G-X-X-G motif; other site 1097669007595 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1097669007596 G-X-X-G motif; other site 1097669007597 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1097669007598 Sm and related proteins; Region: Sm_like; cl00259 1097669007599 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1097669007600 putative oligomer interface [polypeptide binding]; other site 1097669007601 putative RNA binding site [nucleotide binding]; other site 1097669007602 Mitochondrial ATP synthase g subunit; Region: ATP-synt_G; pfam04718 1097669007603 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1097669007604 dinuclear metal binding motif [ion binding]; other site 1097669007605 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1097669007606 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1097669007607 dimer interface [polypeptide binding]; other site 1097669007608 motif 1; other site 1097669007609 active site 1097669007610 motif 2; other site 1097669007611 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 1097669007612 putative deacylase active site [active] 1097669007613 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1097669007614 active site 1097669007615 motif 3; other site 1097669007616 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1097669007617 anticodon binding site; other site 1097669007618 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1097669007619 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1097669007620 putative substrate translocation pore; other site 1097669007621 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 1097669007622 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1097669007623 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1097669007624 homodimer interface [polypeptide binding]; other site 1097669007625 active site 1097669007626 SAM binding site [chemical binding]; other site 1097669007627 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 1097669007628 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1097669007629 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 1097669007630 catalytic triad [active] 1097669007631 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 1097669007632 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 1097669007633 homodimer interface [polypeptide binding]; other site 1097669007634 Walker A motif; other site 1097669007635 ATP binding site [chemical binding]; other site 1097669007636 hydroxycobalamin binding site [chemical binding]; other site 1097669007637 Walker B motif; other site 1097669007638 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 1097669007639 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1097669007640 Walker A motif; other site 1097669007641 ATP binding site [chemical binding]; other site 1097669007642 Walker B motif; other site 1097669007643 arginine finger; other site 1097669007644 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 1097669007645 metal ion-dependent adhesion site (MIDAS); other site 1097669007646 Predicted acyltransferase [General function prediction only]; Region: ElaA; COG2153 1097669007647 malate:quinone oxidoreductase; Validated; Region: PRK05257 1097669007648 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1097669007649 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1097669007650 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1097669007651 mycothione reductase; Reviewed; Region: PRK07846 1097669007652 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1097669007653 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1097669007654 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1097669007655 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 1097669007656 short chain dehydrogenase; Provisional; Region: PRK06057 1097669007657 classical (c) SDRs; Region: SDR_c; cd05233 1097669007658 NAD(P) binding site [chemical binding]; other site 1097669007659 active site 1097669007660 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1097669007661 NAD(P)+ dependent aldehyde dehydrogenase family; Region: ALDH; cd07078 1097669007662 NAD(P) binding site [chemical binding]; other site 1097669007663 catalytic residues [active] 1097669007664 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1097669007665 active site 1097669007666 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1097669007667 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 1097669007668 putative active site [active] 1097669007669 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 1097669007670 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1097669007671 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1097669007672 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 1097669007673 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 1097669007674 Predicted acetyltransferase [General function prediction only]; Region: COG3393 1097669007675 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 1097669007676 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1097669007677 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1097669007678 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1097669007679 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 1097669007680 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1097669007681 active site 1097669007682 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1097669007683 protein binding site [polypeptide binding]; other site 1097669007684 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1097669007685 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1097669007686 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1097669007687 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1097669007688 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1097669007689 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 1097669007690 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 1097669007691 Fasciclin domain; Region: Fasciclin; pfam02469 1097669007692 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1097669007693 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1097669007694 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 1097669007695 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1097669007696 catalytic residues [active] 1097669007697 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 1097669007698 Fasciclin domain; Region: Fasciclin; pfam02469 1097669007699 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 1097669007700 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1097669007701 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 1097669007702 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1097669007703 catalytic residues [active] 1097669007704 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 1097669007705 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1097669007706 FeS/SAM binding site; other site 1097669007707 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 1097669007708 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1097669007709 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1097669007710 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1097669007711 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1097669007712 hinge region; other site 1097669007713 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1097669007714 putative nucleotide binding site [chemical binding]; other site 1097669007715 uridine monophosphate binding site [chemical binding]; other site 1097669007716 homohexameric interface [polypeptide binding]; other site 1097669007717 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1097669007718 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1097669007719 DNA binding site [nucleotide binding] 1097669007720 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1097669007721 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1097669007722 Probable transposase; Region: OrfB_IS605; pfam01385 1097669007723 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 1097669007724 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 1097669007725 catalytic residues [active] 1097669007726 catalytic nucleophile [active] 1097669007727 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1097669007728 MarR family; Region: MarR; pfam01047 1097669007729 amidase; Provisional; Region: PRK07869 1097669007730 Amidase; Region: Amidase; pfam01425 1097669007731 elongation factor Ts; Provisional; Region: tsf; PRK09377 1097669007732 UBA/TS-N domain; Region: UBA; pfam00627 1097669007733 Elongation factor TS; Region: EF_TS; pfam00889 1097669007734 Elongation factor TS; Region: EF_TS; pfam00889 1097669007735 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1097669007736 rRNA interaction site [nucleotide binding]; other site 1097669007737 S8 interaction site; other site 1097669007738 putative laminin-1 binding site; other site 1097669007739 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1097669007740 Peptidase family M23; Region: Peptidase_M23; pfam01551 1097669007741 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1097669007742 PPE family; Region: PPE; pfam00823 1097669007743 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1097669007744 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 1097669007745 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1097669007746 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1097669007747 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1097669007748 active site 1097669007749 DNA binding site [nucleotide binding] 1097669007750 Int/Topo IB signature motif; other site 1097669007751 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1097669007752 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1097669007753 FAD binding pocket [chemical binding]; other site 1097669007754 FAD binding motif [chemical binding]; other site 1097669007755 phosphate binding motif [ion binding]; other site 1097669007756 NAD binding pocket [chemical binding]; other site 1097669007757 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 1097669007758 DNA protecting protein DprA; Region: dprA; TIGR00732 1097669007759 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1097669007760 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1097669007761 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1097669007762 Walker A motif; other site 1097669007763 ATP binding site [chemical binding]; other site 1097669007764 Walker B motif; other site 1097669007765 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1097669007766 hypothetical protein; Reviewed; Region: PRK12497 1097669007767 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 1097669007768 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 1097669007769 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 1097669007770 putative molybdopterin cofactor binding site [chemical binding]; other site 1097669007771 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 1097669007772 putative molybdopterin cofactor binding site; other site 1097669007773 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 1097669007774 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1097669007775 RNA/DNA hybrid binding site [nucleotide binding]; other site 1097669007776 active site 1097669007777 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1097669007778 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1097669007779 Catalytic site [active] 1097669007780 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1097669007781 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1097669007782 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1097669007783 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1097669007784 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1097669007785 RimM N-terminal domain; Region: RimM; pfam01782 1097669007786 hypothetical protein; Provisional; Region: PRK02821 1097669007787 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 1097669007788 G-X-X-G motif; other site 1097669007789 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 1097669007790 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 1097669007791 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1097669007792 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1097669007793 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1097669007794 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1097669007795 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 1097669007796 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 1097669007797 active site 1097669007798 putative substrate binding pocket [chemical binding]; other site 1097669007799 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1097669007800 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1097669007801 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1097669007802 active site 1097669007803 ATP binding site [chemical binding]; other site 1097669007804 substrate binding site [chemical binding]; other site 1097669007805 activation loop (A-loop); other site 1097669007806 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 1097669007807 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 1097669007808 active site 1097669007809 signal recognition particle protein; Provisional; Region: PRK10867 1097669007810 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1097669007811 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1097669007812 P loop; other site 1097669007813 GTP binding site [chemical binding]; other site 1097669007814 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1097669007815 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1097669007816 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1097669007817 ATP binding site [chemical binding]; other site 1097669007818 putative Mg++ binding site [ion binding]; other site 1097669007819 PII uridylyl-transferase; Provisional; Region: PRK03381 1097669007820 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1097669007821 metal binding triad; other site 1097669007822 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1097669007823 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1097669007824 Zn2+ binding site [ion binding]; other site 1097669007825 Mg2+ binding site [ion binding]; other site 1097669007826 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1097669007827 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1097669007828 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1097669007829 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 1097669007830 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1097669007831 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1097669007832 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1097669007833 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1097669007834 Walker A/P-loop; other site 1097669007835 ATP binding site [chemical binding]; other site 1097669007836 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 1097669007837 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1097669007838 ABC transporter signature motif; other site 1097669007839 Walker B; other site 1097669007840 D-loop; other site 1097669007841 H-loop/switch region; other site 1097669007842 acylphosphatase; Provisional; Region: PRK14422 1097669007843 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 1097669007844 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1097669007845 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1097669007846 DNA binding site [nucleotide binding] 1097669007847 catalytic residue [active] 1097669007848 H2TH interface [polypeptide binding]; other site 1097669007849 putative catalytic residues [active] 1097669007850 turnover-facilitating residue; other site 1097669007851 intercalation triad [nucleotide binding]; other site 1097669007852 8OG recognition residue [nucleotide binding]; other site 1097669007853 putative reading head residues; other site 1097669007854 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1097669007855 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1097669007856 ribonuclease III; Reviewed; Region: rnc; PRK00102 1097669007857 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1097669007858 dimerization interface [polypeptide binding]; other site 1097669007859 active site 1097669007860 metal binding site [ion binding]; metal-binding site 1097669007861 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1097669007862 dsRNA binding site [nucleotide binding]; other site 1097669007863 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 1097669007864 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 1097669007865 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 1097669007866 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1097669007867 acyl-CoA synthetase; Validated; Region: PRK05850 1097669007868 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1097669007869 acyl-activating enzyme (AAE) consensus motif; other site 1097669007870 active site 1097669007871 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1097669007872 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1097669007873 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1097669007874 active site 1097669007875 Acyl transferase domain; Region: Acyl_transf_1; pfam00698 1097669007876 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1097669007877 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 1097669007878 NADP binding site [chemical binding]; other site 1097669007879 KR domain; Region: KR; pfam08659 1097669007880 active site 1097669007881 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1097669007882 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1097669007883 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1097669007884 active site 1097669007885 Acyl transferase domain; Region: Acyl_transf_1; cl08282 1097669007886 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 1097669007887 KR domain; Region: KR; pfam08659 1097669007888 NADP binding site [chemical binding]; other site 1097669007889 active site 1097669007890 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1097669007891 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1097669007892 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1097669007893 active site 1097669007894 Acyl transferase domain; Region: Acyl_transf_1; cl08282 1097669007895 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1097669007896 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1097669007897 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1097669007898 Enoylreductase; Region: PKS_ER; smart00829 1097669007899 NAD(P) binding site [chemical binding]; other site 1097669007900 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1097669007901 KR domain; Region: KR; pfam08659 1097669007902 putative NADP binding site [chemical binding]; other site 1097669007903 active site 1097669007904 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1097669007905 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1097669007906 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1097669007907 active site 1097669007908 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1097669007909 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1097669007910 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1097669007911 KR domain; Region: KR; pfam08659 1097669007912 putative NADP binding site [chemical binding]; other site 1097669007913 active site 1097669007914 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1097669007915 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1097669007916 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1097669007917 active site 1097669007918 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1097669007919 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1097669007920 Condensation domain; Region: Condensation; pfam00668 1097669007921 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1097669007922 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1097669007923 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1097669007924 Walker A/P-loop; other site 1097669007925 ATP binding site [chemical binding]; other site 1097669007926 Q-loop/lid; other site 1097669007927 ABC transporter signature motif; other site 1097669007928 Walker B; other site 1097669007929 D-loop; other site 1097669007930 H-loop/switch region; other site 1097669007931 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1097669007932 ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025 1097669007933 ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025 1097669007934 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1097669007935 acyltransferase PapA5; Provisional; Region: PRK09294 1097669007936 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1097669007937 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1097669007938 active site 1097669007939 Acyl transferase domain; Region: Acyl_transf_1; pfam00698 1097669007940 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1097669007941 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1097669007942 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1097669007943 Enoylreductase; Region: PKS_ER; smart00829 1097669007944 NAD(P) binding site [chemical binding]; other site 1097669007945 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1097669007946 KR domain; Region: KR; pfam08659 1097669007947 putative NADP binding site [chemical binding]; other site 1097669007948 active site 1097669007949 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1097669007950 acyl-CoA synthetase; Validated; Region: PRK05850 1097669007951 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1097669007952 acyl-activating enzyme (AAE) consensus motif; other site 1097669007953 active site 1097669007954 MMPL family; Region: MMPL; pfam03176 1097669007955 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1097669007956 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1097669007957 Integrase core domain; Region: rve; pfam00665 1097669007958 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1097669007959 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 1097669007960 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1097669007961 ATP binding site [chemical binding]; other site 1097669007962 Walker A motif; other site 1097669007963 Walker B motif; other site 1097669007964 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 1097669007965 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1097669007966 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1097669007967 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1097669007968 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1097669007969 Enoylreductase; Region: PKS_ER; smart00829 1097669007970 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1097669007971 NAD(P) binding site [chemical binding]; other site 1097669007972 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 1097669007973 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1097669007974 putative NADP binding site [chemical binding]; other site 1097669007975 active site 1097669007976 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1097669007977 Erythronolide synthase docking; Region: Docking; pfam08990 1097669007978 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1097669007979 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1097669007980 active site 1097669007981 acyl-CoA synthetase; Validated; Region: PRK06060 1097669007982 Benzoate CoA ligase (BCL) and similar adenylate forming enzymes; Region: BCL_like; cd05919 1097669007983 dimer interface [polypeptide binding]; other site 1097669007984 acyl-activating enzyme (AAE) consensus motif; other site 1097669007985 putative active site [active] 1097669007986 putative AMP binding site [chemical binding]; other site 1097669007987 putative CoA binding site [chemical binding]; other site 1097669007988 chemical substrate binding site [chemical binding]; other site 1097669007989 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1097669007990 4-hydroxybenzoate synthetase (chorismate lyase) [Coenzyme metabolism]; Region: UbiC; COG3161 1097669007991 acyl-CoA synthetase; Validated; Region: PRK05850 1097669007992 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1097669007993 acyl-activating enzyme (AAE) consensus motif; other site 1097669007994 active site 1097669007995 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1097669007996 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1097669007997 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1097669007998 S-adenosylmethionine binding site [chemical binding]; other site 1097669007999 Uncharacterized conserved protein [Function unknown]; Region: COG3268 1097669008000 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1097669008001 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1097669008002 S-adenosylmethionine binding site [chemical binding]; other site 1097669008003 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 1097669008004 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 1097669008005 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 1097669008006 metal-binding site 1097669008007 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1097669008008 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1097669008009 active site 1097669008010 TDP-binding site; other site 1097669008011 acceptor substrate-binding pocket; other site 1097669008012 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1097669008013 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 1097669008014 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1097669008015 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1097669008016 active site 1097669008017 TDP-binding site; other site 1097669008018 acceptor substrate-binding pocket; other site 1097669008019 Predicted permease; Region: DUF318; pfam03773 1097669008020 formyltetrahydrofolate deformylase; Region: PurU; TIGR00655 1097669008021 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1097669008022 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1097669008023 putative active site [active] 1097669008024 putative substrate binding site [chemical binding]; other site 1097669008025 putative cosubstrate binding site; other site 1097669008026 catalytic site [active] 1097669008027 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1097669008028 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1097669008029 active site 1097669008030 (T/H)XGH motif; other site 1097669008031 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 1097669008032 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1097669008033 S-adenosylmethionine binding site [chemical binding]; other site 1097669008034 pyruvate carboxylase; Reviewed; Region: PRK12999 1097669008035 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1097669008036 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1097669008037 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1097669008038 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1097669008039 active site 1097669008040 catalytic residues [active] 1097669008041 metal binding site [ion binding]; metal-binding site 1097669008042 homodimer binding site [polypeptide binding]; other site 1097669008043 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1097669008044 carboxyltransferase (CT) interaction site; other site 1097669008045 biotinylation site [posttranslational modification]; other site 1097669008046 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 1097669008047 putative active site [active] 1097669008048 redox center [active] 1097669008049 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1097669008050 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 1097669008051 catalytic residues [active] 1097669008052 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1097669008053 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1097669008054 substrate binding pocket [chemical binding]; other site 1097669008055 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 1097669008056 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1097669008057 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1097669008058 active site 1097669008059 catalytic tetrad [active] 1097669008060 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1097669008061 RecG-like helicase [DNA replication, recombination, and repair / Transcription]; Region: RecG; COG1200 1097669008062 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1097669008063 generic binding surface II; other site 1097669008064 ssDNA binding site; other site 1097669008065 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1097669008066 ATP binding site [chemical binding]; other site 1097669008067 putative Mg++ binding site [ion binding]; other site 1097669008068 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1097669008069 nucleotide binding region [chemical binding]; other site 1097669008070 ATP-binding site [chemical binding]; other site 1097669008071 potential frameshift: common BLAST hit: gi|340627964|ref|YP_004746416.1| dak2 domain-containing protein 1097669008072 DAK2 domain; Region: Dak2; cl03685 1097669008073 Dihydroxyacetone kinase family; Region: Dak1_2; pfam13684 1097669008074 DAK2 domain; Region: Dak2; cl03685 1097669008075 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1097669008076 ligand binding site [chemical binding]; other site 1097669008077 active site 1097669008078 UGI interface [polypeptide binding]; other site 1097669008079 catalytic site [active] 1097669008080 thiamine monophosphate kinase; Provisional; Region: PRK05731 1097669008081 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1097669008082 ATP binding site [chemical binding]; other site 1097669008083 dimerization interface [polypeptide binding]; other site 1097669008084 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1097669008085 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1097669008086 Probable transposase; Region: OrfB_IS605; pfam01385 1097669008087 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 1097669008088 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 1097669008089 catalytic residues [active] 1097669008090 catalytic nucleophile [active] 1097669008091 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 1097669008092 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1097669008093 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1097669008094 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1097669008095 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1097669008096 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1097669008097 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1097669008098 Predicted nucleotidyltransferase, CobY/MobA/RfbA family [General function prediction only]; Region: COG1920 1097669008099 polyphosphate kinase; Provisional; Region: PRK05443 1097669008100 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1097669008101 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1097669008102 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 1097669008103 putative domain interface [polypeptide binding]; other site 1097669008104 putative active site [active] 1097669008105 catalytic site [active] 1097669008106 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 1097669008107 putative domain interface [polypeptide binding]; other site 1097669008108 putative active site [active] 1097669008109 catalytic site [active] 1097669008110 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1097669008111 active site 1097669008112 Ap6A binding site [chemical binding]; other site 1097669008113 nudix motif; other site 1097669008114 metal binding site [ion binding]; metal-binding site 1097669008115 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1097669008116 catalytic core [active] 1097669008117 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1097669008118 IHF - DNA interface [nucleotide binding]; other site 1097669008119 IHF dimer interface [polypeptide binding]; other site 1097669008120 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1097669008121 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1097669008122 substrate binding site [chemical binding]; other site 1097669008123 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1097669008124 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1097669008125 substrate binding site [chemical binding]; other site 1097669008126 ligand binding site [chemical binding]; other site 1097669008127 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1097669008128 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1097669008129 Bacterial transcriptional regulator; Region: IclR; pfam01614 1097669008130 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1097669008131 S-adenosylmethionine binding site [chemical binding]; other site 1097669008132 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 1097669008133 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1097669008134 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1097669008135 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1097669008136 active site 1097669008137 HIGH motif; other site 1097669008138 nucleotide binding site [chemical binding]; other site 1097669008139 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1097669008140 active site 1097669008141 KMSKS motif; other site 1097669008142 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1097669008143 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 1097669008144 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1097669008145 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1097669008146 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1097669008147 putative substrate translocation pore; other site 1097669008148 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 1097669008149 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 1097669008150 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1097669008151 ligand binding site [chemical binding]; other site 1097669008152 NAD binding site [chemical binding]; other site 1097669008153 dimerization interface [polypeptide binding]; other site 1097669008154 catalytic site [active] 1097669008155 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 1097669008156 putative L-serine binding site [chemical binding]; other site 1097669008157 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1097669008158 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1097669008159 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1097669008160 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1097669008161 phosphorylation site [posttranslational modification] 1097669008162 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 1097669008163 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 1097669008164 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 1097669008165 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1097669008166 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1097669008167 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1097669008168 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1097669008169 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1097669008170 putative valine binding site [chemical binding]; other site 1097669008171 dimer interface [polypeptide binding]; other site 1097669008172 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1097669008173 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 1097669008174 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1097669008175 PYR/PP interface [polypeptide binding]; other site 1097669008176 dimer interface [polypeptide binding]; other site 1097669008177 TPP binding site [chemical binding]; other site 1097669008178 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1097669008179 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1097669008180 TPP-binding site [chemical binding]; other site 1097669008181 dimer interface [polypeptide binding]; other site 1097669008182 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1097669008183 Predicted membrane protein [Function unknown]; Region: COG2259 1097669008184 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 1097669008185 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1097669008186 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1097669008187 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1097669008188 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1097669008189 GatB domain; Region: GatB_Yqey; smart00845 1097669008190 6-phosphofructokinase; Provisional; Region: PRK03202 1097669008191 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1097669008192 active site 1097669008193 ADP/pyrophosphate binding site [chemical binding]; other site 1097669008194 dimerization interface [polypeptide binding]; other site 1097669008195 allosteric effector site; other site 1097669008196 fructose-1,6-bisphosphate binding site; other site 1097669008197 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1097669008198 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1097669008199 aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, C subunit; Region: gatC; TIGR00135 1097669008200 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 1097669008201 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1097669008202 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1097669008203 nucleotide binding pocket [chemical binding]; other site 1097669008204 K-X-D-G motif; other site 1097669008205 catalytic site [active] 1097669008206 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1097669008207 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1097669008208 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1097669008209 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1097669008210 Dimer interface [polypeptide binding]; other site 1097669008211 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310 1097669008212 PknH-like extracellular domain; Region: PknH_C; pfam14032 1097669008213 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1097669008214 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1097669008215 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 1097669008216 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1097669008217 Ligand Binding Site [chemical binding]; other site 1097669008218 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1097669008219 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1097669008220 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1097669008221 catalytic residue [active] 1097669008222 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1097669008223 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1097669008224 putative acyl-acceptor binding pocket; other site 1097669008225 Putative hemolysin [General function prediction only]; Region: COG3176 1097669008226 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1097669008227 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1097669008228 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1097669008229 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1097669008230 Ligand binding site [chemical binding]; other site 1097669008231 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1097669008232 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1097669008233 S-adenosylmethionine binding site [chemical binding]; other site 1097669008234 Uncharacterized conserved protein [Function unknown]; Region: COG1543 1097669008235 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 1097669008236 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 1097669008237 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1097669008238 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1097669008239 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 1097669008240 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 1097669008241 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1097669008242 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1097669008243 trimer interface [polypeptide binding]; other site 1097669008244 active site 1097669008245 substrate binding site [chemical binding]; other site 1097669008246 CoA binding site [chemical binding]; other site 1097669008247 FOG: WD40-like repeat [Function unknown]; Region: COG1520 1097669008248 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1097669008249 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1097669008250 S-adenosylmethionine binding site [chemical binding]; other site 1097669008251 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1097669008252 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1097669008253 substrate binding site [chemical binding]; other site 1097669008254 oxyanion hole (OAH) forming residues; other site 1097669008255 trimer interface [polypeptide binding]; other site 1097669008256 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119 1097669008257 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1097669008258 Walker A/P-loop; other site 1097669008259 ATP binding site [chemical binding]; other site 1097669008260 Q-loop/lid; other site 1097669008261 ABC transporter signature motif; other site 1097669008262 Walker B; other site 1097669008263 D-loop; other site 1097669008264 H-loop/switch region; other site 1097669008265 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 1097669008266 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 1097669008267 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1097669008268 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1097669008269 motif II; other site 1097669008270 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1097669008271 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1097669008272 D-pathway; other site 1097669008273 Putative ubiquinol binding site [chemical binding]; other site 1097669008274 Low-spin heme (heme b) binding site [chemical binding]; other site 1097669008275 Putative water exit pathway; other site 1097669008276 Binuclear center (heme o3/CuB) [ion binding]; other site 1097669008277 K-pathway; other site 1097669008278 Putative proton exit pathway; other site 1097669008279 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1097669008280 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1097669008281 siderophore binding site; other site 1097669008282 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1097669008283 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1097669008284 putative NAD(P) binding site [chemical binding]; other site 1097669008285 putative substrate binding site [chemical binding]; other site 1097669008286 catalytic Zn binding site [ion binding]; other site 1097669008287 structural Zn binding site [ion binding]; other site 1097669008288 dimer interface [polypeptide binding]; other site 1097669008289 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 1097669008290 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1097669008291 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1097669008292 dimer interface [polypeptide binding]; other site 1097669008293 putative radical transfer pathway; other site 1097669008294 diiron center [ion binding]; other site 1097669008295 tyrosyl radical; other site 1097669008296 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1097669008297 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1097669008298 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1097669008299 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1097669008300 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 1097669008301 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1097669008302 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1097669008303 active site 1097669008304 dimer interface [polypeptide binding]; other site 1097669008305 catalytic residues [active] 1097669008306 effector binding site; other site 1097669008307 R2 peptide binding site; other site 1097669008308 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 1097669008309 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1097669008310 catalytic residues [active] 1097669008311 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1097669008312 Predicted flavoprotein [General function prediction only]; Region: COG0431 1097669008313 DNA polymerase IV; Validated; Region: PRK03352 1097669008314 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1097669008315 active site 1097669008316 DNA binding site [nucleotide binding] 1097669008317 short chain dehydrogenase; Provisional; Region: PRK07832 1097669008318 classical (c) SDRs; Region: SDR_c; cd05233 1097669008319 NAD(P) binding site [chemical binding]; other site 1097669008320 active site 1097669008321 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1097669008322 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1097669008323 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1097669008324 Cytochrome P450; Region: p450; cl12078 1097669008325 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1097669008326 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1097669008327 DNA-binding site [nucleotide binding]; DNA binding site 1097669008328 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1097669008329 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1097669008330 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1097669008331 DNA-binding site [nucleotide binding]; DNA binding site 1097669008332 FCD domain; Region: FCD; pfam07729 1097669008333 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1097669008334 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1097669008335 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1097669008336 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1097669008337 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1097669008338 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1097669008339 active site 1097669008340 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180 1097669008341 Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901 1097669008342 active site 1097669008343 DNA binding site [nucleotide binding] 1097669008344 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 1097669008345 DNA binding site [nucleotide binding] 1097669008346 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 1097669008347 Carbon starvation protein CstA; Region: CstA; pfam02554 1097669008348 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1097669008349 Predicted membrane protein [Function unknown]; Region: COG2259 1097669008350 Small Multidrug Resistance protein; Region: Multi_Drug_Res; pfam00893 1097669008351 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 1097669008352 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1097669008353 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1097669008354 phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132 1097669008355 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 1097669008356 active site 1097669008357 substrate binding site [chemical binding]; other site 1097669008358 metal binding site [ion binding]; metal-binding site 1097669008359 camphor resistance protein CrcB; Provisional; Region: PRK14216 1097669008360 camphor resistance protein CrcB; Provisional; Region: PRK14228 1097669008361 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 1097669008362 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 1097669008363 Uncharacterized ACR, COG1993; Region: DUF190; pfam02641 1097669008364 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1097669008365 Uncharacterized conserved protein [Function unknown]; Region: COG3189 1097669008366 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1097669008367 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1097669008368 active site 1097669008369 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1097669008370 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 1097669008371 putative hydrophobic ligand binding site [chemical binding]; other site 1097669008372 protein interface [polypeptide binding]; other site 1097669008373 gate; other site 1097669008374 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1097669008375 Sulfatase; Region: Sulfatase; pfam00884 1097669008376 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1097669008377 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1097669008378 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1097669008379 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1097669008380 active site 1097669008381 ATP binding site [chemical binding]; other site 1097669008382 substrate binding site [chemical binding]; other site 1097669008383 activation loop (A-loop); other site 1097669008384 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 1097669008385 AAA ATPase domain; Region: AAA_16; pfam13191 1097669008386 Nucleotidyl transferase of unknown function (DUF2204); Region: DUF2204; pfam09970 1097669008387 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1097669008388 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1097669008389 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1097669008390 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1097669008391 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1097669008392 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1097669008393 short chain dehydrogenase; Provisional; Region: PRK07832 1097669008394 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1097669008395 NAD(P) binding site [chemical binding]; other site 1097669008396 active site 1097669008397 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 1097669008398 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1097669008399 NAD binding site [chemical binding]; other site 1097669008400 catalytic Zn binding site [ion binding]; other site 1097669008401 substrate binding site [chemical binding]; other site 1097669008402 structural Zn binding site [ion binding]; other site 1097669008403 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1097669008404 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1097669008405 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1097669008406 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1097669008407 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 1097669008408 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1097669008409 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1097669008410 acyl-activating enzyme (AAE) consensus motif; other site 1097669008411 AMP binding site [chemical binding]; other site 1097669008412 active site 1097669008413 CoA binding site [chemical binding]; other site 1097669008414 SPFH domain / Band 7 family; Region: Band_7; pfam01145 1097669008415 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1097669008416 Patatin-like phospholipase; Region: Patatin; pfam01734 1097669008417 Protein of unknown function (DUF808); Region: DUF808; cl01002 1097669008418 probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841 1097669008419 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1097669008420 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1097669008421 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1097669008422 active site 1097669008423 Predicted transcriptional regulators [Transcription]; Region: COG1733 1097669008424 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1097669008425 dimerization interface [polypeptide binding]; other site 1097669008426 putative DNA binding site [nucleotide binding]; other site 1097669008427 putative Zn2+ binding site [ion binding]; other site 1097669008428 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 1097669008429 PE family; Region: PE; pfam00934 1097669008430 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1097669008431 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1097669008432 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1097669008433 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1097669008434 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1097669008435 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1097669008436 SmpB-tmRNA interface; other site 1097669008437 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1097669008438 FtsX-like permease family; Region: FtsX; pfam02687 1097669008439 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1097669008440 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1097669008441 Walker A/P-loop; other site 1097669008442 ATP binding site [chemical binding]; other site 1097669008443 Q-loop/lid; other site 1097669008444 ABC transporter signature motif; other site 1097669008445 Walker B; other site 1097669008446 D-loop; other site 1097669008447 H-loop/switch region; other site 1097669008448 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1097669008449 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1097669008450 peptide chain release factor 2; Validated; Region: prfB; PRK00578 1097669008451 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1097669008452 RF-1 domain; Region: RF-1; pfam00472 1097669008453 ferredoxin-NADP+ reductase; Region: PLN02852 1097669008454 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1097669008455 FAD binding domain; Region: FAD_binding_4; pfam01565 1097669008456 Molybdenum cofactor biosynthesis enzyme [Coenzyme metabolism]; Region: MoaA; COG2896 1097669008457 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1097669008458 FeS/SAM binding site; other site 1097669008459 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1097669008460 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 1097669008461 aromatic arch; other site 1097669008462 DCoH dimer interaction site [polypeptide binding]; other site 1097669008463 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 1097669008464 DCoH tetramer interaction site [polypeptide binding]; other site 1097669008465 substrate binding site [chemical binding]; other site 1097669008466 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1097669008467 trimer interface [polypeptide binding]; other site 1097669008468 dimer interface [polypeptide binding]; other site 1097669008469 putative active site [active] 1097669008470 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1097669008471 MoaE interaction surface [polypeptide binding]; other site 1097669008472 MoeB interaction surface [polypeptide binding]; other site 1097669008473 thiocarboxylated glycine; other site 1097669008474 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1097669008475 nucleoside/Zn binding site; other site 1097669008476 dimer interface [polypeptide binding]; other site 1097669008477 catalytic motif [active] 1097669008478 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 1097669008479 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1097669008480 ATP binding site [chemical binding]; other site 1097669008481 substrate interface [chemical binding]; other site 1097669008482 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1097669008483 active site residue [active] 1097669008484 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1097669008485 MoaE homodimer interface [polypeptide binding]; other site 1097669008486 MoaD interaction [polypeptide binding]; other site 1097669008487 active site residues [active] 1097669008488 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1097669008489 S-adenosylmethionine binding site [chemical binding]; other site 1097669008490 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1097669008491 Cytochrome P450; Region: p450; cl12078 1097669008492 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 1097669008493 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 1097669008494 DNA binding site [nucleotide binding] 1097669008495 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1097669008496 PPE family; Region: PPE; pfam00823 1097669008497 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1097669008498 pseudo 1097669008499 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 1097669008500 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1097669008501 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1097669008502 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1097669008503 dimer interface [polypeptide binding]; other site 1097669008504 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1097669008505 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1097669008506 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1097669008507 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1097669008508 Histidine kinase; Region: HisKA_3; pfam07730 1097669008509 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1097669008510 ATP binding site [chemical binding]; other site 1097669008511 Mg2+ binding site [ion binding]; other site 1097669008512 G-X-G motif; other site 1097669008513 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1097669008514 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1097669008515 active site 1097669008516 phosphorylation site [posttranslational modification] 1097669008517 intermolecular recognition site; other site 1097669008518 dimerization interface [polypeptide binding]; other site 1097669008519 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1097669008520 DNA binding residues [nucleotide binding] 1097669008521 dimerization interface [polypeptide binding]; other site 1097669008522 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1097669008523 Ligand Binding Site [chemical binding]; other site 1097669008524 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1097669008525 PPE family; Region: PPE; pfam00823 1097669008526 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1097669008527 PPE family; Region: PPE; pfam00823 1097669008528 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1097669008529 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1097669008530 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 1097669008531 active site 1097669008532 AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337 1097669008533 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1097669008534 FeS/SAM binding site; other site 1097669008535 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1097669008536 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1097669008537 active site 1097669008538 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1097669008539 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1097669008540 active site 1097669008541 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1097669008542 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 1097669008543 NAD(P) binding site [chemical binding]; other site 1097669008544 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1097669008545 active site 1097669008546 phosphorylation site [posttranslational modification] 1097669008547 intermolecular recognition site; other site 1097669008548 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1097669008549 PPE family; Region: PPE; pfam00823 1097669008550 NADH dehydrogenase subunit A; Validated; Region: PRK07928 1097669008551 NADH dehydrogenase subunit B; Validated; Region: PRK06411 1097669008552 NADH dehydrogenase subunit C; Provisional; Region: PRK07785 1097669008553 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 1097669008554 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 1097669008555 NADH dehydrogenase subunit D; Validated; Region: PRK06075 1097669008556 NADH dehydrogenase subunit E; Validated; Region: PRK07539 1097669008557 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1097669008558 putative dimer interface [polypeptide binding]; other site 1097669008559 [2Fe-2S] cluster binding site [ion binding]; other site 1097669008560 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 1097669008561 SLBB domain; Region: SLBB; pfam10531 1097669008562 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 1097669008563 NADH dehydrogenase subunit G; Validated; Region: PRK07860 1097669008564 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1097669008565 catalytic loop [active] 1097669008566 iron binding site [ion binding]; other site 1097669008567 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1097669008568 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 1097669008569 [4Fe-4S] binding site [ion binding]; other site 1097669008570 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 1097669008571 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1097669008572 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1097669008573 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 1097669008574 4Fe-4S binding domain; Region: Fer4; pfam00037 1097669008575 4Fe-4S binding domain; Region: Fer4; pfam00037 1097669008576 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 1097669008577 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 1097669008578 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 1097669008579 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1097669008580 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1097669008581 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 1097669008582 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1097669008583 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1097669008584 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1097669008585 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1097669008586 PPE family; Region: PPE; pfam00823 1097669008587 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 1097669008588 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1097669008589 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1097669008590 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1097669008591 [2Fe-2S] cluster binding site [ion binding]; other site 1097669008592 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_1; cd08885 1097669008593 putative alpha subunit interface [polypeptide binding]; other site 1097669008594 putative active site [active] 1097669008595 putative substrate binding site [chemical binding]; other site 1097669008596 Fe binding site [ion binding]; other site 1097669008597 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1097669008598 Protein of unknown function DUF58; Region: DUF58; pfam01882 1097669008599 MoxR-like ATPases [General function prediction only]; Region: COG0714 1097669008600 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1097669008601 Walker A motif; other site 1097669008602 ATP binding site [chemical binding]; other site 1097669008603 Walker B motif; other site 1097669008604 arginine finger; other site 1097669008605 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 1097669008606 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1097669008607 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1097669008608 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1097669008609 putative active site [active] 1097669008610 putative substrate binding site [chemical binding]; other site 1097669008611 ATP binding site [chemical binding]; other site 1097669008612 Phosphotransferase enzyme family; Region: APH; pfam01636 1097669008613 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 1097669008614 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1097669008615 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1097669008616 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1097669008617 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1097669008618 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1097669008619 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1097669008620 short chain dehydrogenase; Validated; Region: PRK08264 1097669008621 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1097669008622 NAD(P) binding site [chemical binding]; other site 1097669008623 active site 1097669008624 amidase; Provisional; Region: PRK06170 1097669008625 Amidase; Region: Amidase; pfam01425 1097669008626 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1097669008627 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1097669008628 TAP-like protein; Region: Abhydrolase_4; pfam08386 1097669008629 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1097669008630 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 1097669008631 AAA domain; Region: AAA_14; pfam13173 1097669008632 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1097669008633 putative active site [active] 1097669008634 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1097669008635 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4683 1097669008636 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1097669008637 non-specific DNA binding site [nucleotide binding]; other site 1097669008638 salt bridge; other site 1097669008639 sequence-specific DNA binding site [nucleotide binding]; other site 1097669008640 RES domain; Region: RES; pfam08808 1097669008641 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1097669008642 Helix-turn-helix domain; Region: HTH_38; pfam13936 1097669008643 Integrase core domain; Region: rve; pfam00665 1097669008644 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1097669008645 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1097669008646 hypothetical protein; Validated; Region: PRK00068 1097669008647 Uncharacterized conserved protein [Function unknown]; Region: COG1615 1097669008648 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 1097669008649 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 1097669008650 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 1097669008651 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1097669008652 Uncharacterized conserved protein [Function unknown]; Region: COG5282 1097669008653 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 1097669008654 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 1097669008655 ABC1 family; Region: ABC1; pfam03109 1097669008656 Phosphotransferase enzyme family; Region: APH; pfam01636 1097669008657 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1097669008658 active site 1097669008659 ATP binding site [chemical binding]; other site 1097669008660 Transcription factor WhiB; Region: Whib; pfam02467 1097669008661 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1097669008662 Part of AAA domain; Region: AAA_19; pfam13245 1097669008663 Family description; Region: UvrD_C_2; pfam13538 1097669008664 HRDC domain; Region: HRDC; pfam00570 1097669008665 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1097669008666 catalytic residues [active] 1097669008667 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 1097669008668 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 1097669008669 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 1097669008670 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1097669008671 putative NADH binding site [chemical binding]; other site 1097669008672 putative active site [active] 1097669008673 nudix motif; other site 1097669008674 putative metal binding site [ion binding]; other site 1097669008675 Ion channel; Region: Ion_trans_2; pfam07885 1097669008676 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1097669008677 TrkA-N domain; Region: TrkA_N; pfam02254 1097669008678 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1097669008679 Part of AAA domain; Region: AAA_19; pfam13245 1097669008680 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 1097669008681 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1097669008682 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1097669008683 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 1097669008684 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1097669008685 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1097669008686 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1097669008687 active site 1097669008688 DNA binding site [nucleotide binding] 1097669008689 TIGR02569 family protein; Region: TIGR02569_actnb 1097669008690 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 1097669008691 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1097669008692 ATP binding site [chemical binding]; other site 1097669008693 substrate interface [chemical binding]; other site 1097669008694 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1097669008695 active site residue [active] 1097669008696 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 1097669008697 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1097669008698 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1097669008699 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 1097669008700 tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like; Region: MiaE_2; pfam13794 1097669008701 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1097669008702 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1097669008703 ATP binding site [chemical binding]; other site 1097669008704 Mg++ binding site [ion binding]; other site 1097669008705 motif III; other site 1097669008706 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1097669008707 nucleotide binding region [chemical binding]; other site 1097669008708 ATP-binding site [chemical binding]; other site 1097669008709 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1097669008710 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1097669008711 P-loop; other site 1097669008712 Magnesium ion binding site [ion binding]; other site 1097669008713 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1097669008714 Magnesium ion binding site [ion binding]; other site 1097669008715 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1097669008716 catalytic core [active] 1097669008717 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 1097669008718 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1097669008719 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1097669008720 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1097669008721 Transcription factor WhiB; Region: Whib; pfam02467 1097669008722 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 1097669008723 PAS domain S-box; Region: sensory_box; TIGR00229 1097669008724 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1097669008725 Histidine kinase; Region: HisKA_2; pfam07568 1097669008726 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1097669008727 ATP binding site [chemical binding]; other site 1097669008728 Mg2+ binding site [ion binding]; other site 1097669008729 G-X-G motif; other site 1097669008730 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1097669008731 carboxyltransferase (CT) interaction site; other site 1097669008732 biotinylation site [posttranslational modification]; other site 1097669008733 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; TIGR03988 1097669008734 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 1097669008735 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1097669008736 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1097669008737 DNA binding residues [nucleotide binding] 1097669008738 short chain dehydrogenase; Provisional; Region: PRK08278 1097669008739 human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762 1097669008740 NAD(P) binding site [chemical binding]; other site 1097669008741 homodimer interface [polypeptide binding]; other site 1097669008742 active site 1097669008743 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 1097669008744 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 1097669008745 putative deacylase active site [active] 1097669008746 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1097669008747 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1097669008748 Coenzyme A binding pocket [chemical binding]; other site 1097669008749 Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases; Region: APH_ChoK_like_1; cd05155 1097669008750 Phosphotransferase enzyme family; Region: APH; pfam01636 1097669008751 putative active site [active] 1097669008752 putative substrate binding site [chemical binding]; other site 1097669008753 ATP binding site [chemical binding]; other site 1097669008754 Uncharacterized conserved protein [Function unknown]; Region: COG2135 1097669008755 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1097669008756 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1097669008757 hinge; other site 1097669008758 active site 1097669008759 Predicted GTPases [General function prediction only]; Region: COG1162 1097669008760 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1097669008761 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1097669008762 GTP/Mg2+ binding site [chemical binding]; other site 1097669008763 G4 box; other site 1097669008764 G5 box; other site 1097669008765 G1 box; other site 1097669008766 Switch I region; other site 1097669008767 G2 box; other site 1097669008768 G3 box; other site 1097669008769 Switch II region; other site 1097669008770 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1097669008771 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 1097669008772 putative di-iron ligands [ion binding]; other site 1097669008773 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 1097669008774 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1097669008775 FAD binding pocket [chemical binding]; other site 1097669008776 FAD binding motif [chemical binding]; other site 1097669008777 phosphate binding motif [ion binding]; other site 1097669008778 beta-alpha-beta structure motif; other site 1097669008779 NAD binding pocket [chemical binding]; other site 1097669008780 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1097669008781 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1097669008782 catalytic loop [active] 1097669008783 iron binding site [ion binding]; other site 1097669008784 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 1097669008785 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1097669008786 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1097669008787 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1097669008788 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1097669008789 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 1097669008790 TrkA-C domain; Region: TrkA_C; pfam02080 1097669008791 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1097669008792 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1097669008793 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1097669008794 putative substrate translocation pore; other site 1097669008795 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1097669008796 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1097669008797 ligand binding site [chemical binding]; other site 1097669008798 flexible hinge region; other site 1097669008799 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1097669008800 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1097669008801 nucleophile elbow; other site 1097669008802 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1097669008803 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1097669008804 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1097669008805 30S subunit binding site; other site 1097669008806 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1097669008807 active site 1097669008808 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 1097669008809 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1097669008810 lipoprotein LpqB; Provisional; Region: PRK13616 1097669008811 Sporulation and spore germination; Region: Germane; pfam10646 1097669008812 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1097669008813 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1097669008814 dimerization interface [polypeptide binding]; other site 1097669008815 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1097669008816 dimer interface [polypeptide binding]; other site 1097669008817 phosphorylation site [posttranslational modification] 1097669008818 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1097669008819 ATP binding site [chemical binding]; other site 1097669008820 Mg2+ binding site [ion binding]; other site 1097669008821 G-X-G motif; other site 1097669008822 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1097669008823 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1097669008824 active site 1097669008825 phosphorylation site [posttranslational modification] 1097669008826 intermolecular recognition site; other site 1097669008827 dimerization interface [polypeptide binding]; other site 1097669008828 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1097669008829 DNA binding site [nucleotide binding] 1097669008830 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 1097669008831 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1097669008832 TMP-binding site; other site 1097669008833 ATP-binding site [chemical binding]; other site 1097669008834 Adenosylhomocysteinase; Provisional; Region: PTZ00075 1097669008835 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 1097669008836 homotetramer interface [polypeptide binding]; other site 1097669008837 ligand binding site [chemical binding]; other site 1097669008838 catalytic site [active] 1097669008839 NAD binding site [chemical binding]; other site 1097669008840 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1097669008841 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 1097669008842 Rubredoxin [Energy production and conversion]; Region: COG1773 1097669008843 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1097669008844 iron binding site [ion binding]; other site 1097669008845 Rubredoxin [Energy production and conversion]; Region: COG1773 1097669008846 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1097669008847 iron binding site [ion binding]; other site 1097669008848 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 1097669008849 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1097669008850 Di-iron ligands [ion binding]; other site 1097669008851 amino acid transporter; Region: 2A0306; TIGR00909 1097669008852 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1097669008853 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1097669008854 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1097669008855 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1097669008856 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1097669008857 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1097669008858 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 1097669008859 active site 1097669008860 substrate binding site [chemical binding]; other site 1097669008861 metal binding site [ion binding]; metal-binding site 1097669008862 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 1097669008863 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 1097669008864 Transcription factor WhiB; Region: Whib; pfam02467 1097669008865 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 1097669008866 LPPG:FO 2-phospho-L-lactate transferase; important in F420 biosynthesis; Region: CofD_like; cd07186 1097669008867 phosphate binding site [ion binding]; other site 1097669008868 dimer interface [polypeptide binding]; other site 1097669008869 substrate binding site [chemical binding]; other site 1097669008870 F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294 1097669008871 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 1097669008872 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 1097669008873 putative FMN binding site [chemical binding]; other site 1097669008874 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 1097669008875 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1097669008876 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1097669008877 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 1097669008878 active site 1097669008879 Substrate binding site; other site 1097669008880 Mg++ binding site; other site 1097669008881 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1097669008882 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1097669008883 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1097669008884 Probable Catalytic site; other site 1097669008885 metal-binding site 1097669008886 dTDP-4-dehydrorhamnose reductase; Region: rmlD; TIGR01214 1097669008887 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1097669008888 NADP binding site [chemical binding]; other site 1097669008889 active site 1097669008890 putative substrate binding site [chemical binding]; other site 1097669008891 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1097669008892 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1097669008893 TIGR03089 family protein; Region: TIGR03089 1097669008894 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 1097669008895 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1097669008896 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1097669008897 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1097669008898 active site 1097669008899 motif I; other site 1097669008900 motif II; other site 1097669008901 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1097669008902 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1097669008903 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1097669008904 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1097669008905 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1097669008906 Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: CynT; COG0288 1097669008907 active site clefts [active] 1097669008908 zinc binding site [ion binding]; other site 1097669008909 dimer interface [polypeptide binding]; other site 1097669008910 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1097669008911 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 1097669008912 FAD binding site [chemical binding]; other site 1097669008913 homotetramer interface [polypeptide binding]; other site 1097669008914 substrate binding pocket [chemical binding]; other site 1097669008915 catalytic base [active] 1097669008916 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1097669008917 Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase) [Nucleotide transport and metabolism]; Region: PurK; COG0026 1097669008918 ATP-grasp domain; Region: ATP-grasp; pfam02222 1097669008919 Predicted membrane protein [Function unknown]; Region: COG2246 1097669008920 GtrA-like protein; Region: GtrA; pfam04138 1097669008921 Bacterial PH domain; Region: DUF304; pfam03703 1097669008922 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1097669008923 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1097669008924 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1097669008925 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1097669008926 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1097669008927 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1097669008928 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 1097669008929 Maf-like protein; Region: Maf; pfam02545 1097669008930 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1097669008931 active site 1097669008932 dimer interface [polypeptide binding]; other site 1097669008933 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1097669008934 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1097669008935 active site residue [active] 1097669008936 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1097669008937 active site residue [active] 1097669008938 Fe-S metabolism associated domain; Region: SufE; pfam02657 1097669008939 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1097669008940 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1097669008941 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1097669008942 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1097669008943 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1097669008944 carboxyltransferase (CT) interaction site; other site 1097669008945 biotinylation site [posttranslational modification]; other site 1097669008946 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1097669008947 L-lysine aminotransferase; Provisional; Region: PRK08297 1097669008948 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1097669008949 inhibitor-cofactor binding pocket; inhibition site 1097669008950 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1097669008951 catalytic residue [active] 1097669008952 putative DNA binding site [nucleotide binding]; other site 1097669008953 dimerization interface [polypeptide binding]; other site 1097669008954 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1097669008955 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1097669008956 putative Zn2+ binding site [ion binding]; other site 1097669008957 AsnC family; Region: AsnC_trans_reg; pfam01037 1097669008958 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 1097669008959 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 1097669008960 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1097669008961 tetrameric interface [polypeptide binding]; other site 1097669008962 NAD binding site [chemical binding]; other site 1097669008963 catalytic residues [active] 1097669008964 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 1097669008965 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1097669008966 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1097669008967 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1097669008968 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 1097669008969 ATP binding site [chemical binding]; other site 1097669008970 putative Mg++ binding site [ion binding]; other site 1097669008971 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1097669008972 nucleotide binding region [chemical binding]; other site 1097669008973 ATP-binding site [chemical binding]; other site 1097669008974 DEAD/H associated; Region: DEAD_assoc; pfam08494 1097669008975 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1097669008976 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 1097669008977 putative DNA binding site [nucleotide binding]; other site 1097669008978 catalytic residue [active] 1097669008979 putative H2TH interface [polypeptide binding]; other site 1097669008980 putative catalytic residues [active] 1097669008981 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1097669008982 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 1097669008983 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1097669008984 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1097669008985 Sulfatase; Region: Sulfatase; pfam00884 1097669008986 Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558 1097669008987 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1097669008988 probable active site [active] 1097669008989 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1097669008990 PhoU domain; Region: PhoU; pfam01895 1097669008991 PhoU domain; Region: PhoU; pfam01895 1097669008992 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1097669008993 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 1097669008994 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1097669008995 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1097669008996 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1097669008997 putative active site pocket [active] 1097669008998 dimerization interface [polypeptide binding]; other site 1097669008999 putative catalytic residue [active] 1097669009000 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1097669009001 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 1097669009002 metal binding site [ion binding]; metal-binding site 1097669009003 putative dimer interface [polypeptide binding]; other site 1097669009004 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 1097669009005 amidohydrolase; Region: amidohydrolases; TIGR01891 1097669009006 metal binding site [ion binding]; metal-binding site 1097669009007 purine nucleoside phosphorylase; Provisional; Region: PRK08202 1097669009008 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 1097669009009 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1097669009010 active site 1097669009011 substrate binding site [chemical binding]; other site 1097669009012 metal binding site [ion binding]; metal-binding site 1097669009013 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1097669009014 active site 1097669009015 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1097669009016 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1097669009017 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1097669009018 adenosine deaminase; Provisional; Region: PRK09358 1097669009019 active site 1097669009020 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 1097669009021 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1097669009022 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1097669009023 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 1097669009024 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1097669009025 active site 1097669009026 catalytic motif [active] 1097669009027 Zn binding site [ion binding]; other site 1097669009028 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 1097669009029 putative Iron-sulfur protein interface [polypeptide binding]; other site 1097669009030 putative proximal heme binding site [chemical binding]; other site 1097669009031 putative SdhD-like interface [polypeptide binding]; other site 1097669009032 putative distal heme binding site [chemical binding]; other site 1097669009033 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 1097669009034 putative Iron-sulfur protein interface [polypeptide binding]; other site 1097669009035 putative proximal heme binding site [chemical binding]; other site 1097669009036 putative SdhC-like subunit interface [polypeptide binding]; other site 1097669009037 putative distal heme binding site [chemical binding]; other site 1097669009038 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 1097669009039 L-aspartate oxidase; Provisional; Region: PRK06175 1097669009040 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1097669009041 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 1097669009042 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1097669009043 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 1097669009044 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1097669009045 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1097669009046 S-adenosylmethionine binding site [chemical binding]; other site 1097669009047 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1097669009048 MoaE interaction surface [polypeptide binding]; other site 1097669009049 MoeB interaction surface [polypeptide binding]; other site 1097669009050 thiocarboxylated glycine; other site 1097669009051 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1097669009052 MoaE homodimer interface [polypeptide binding]; other site 1097669009053 MoaD interaction [polypeptide binding]; other site 1097669009054 active site residues [active] 1097669009055 MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor...; Region: MoaC; cd00528 1097669009056 trimer interface [polypeptide binding]; other site 1097669009057 dimer interface [polypeptide binding]; other site 1097669009058 pseudo 1097669009059 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1097669009060 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 1097669009061 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1097669009062 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1097669009063 DNA binding residues [nucleotide binding] 1097669009064 SnoaL-like domain; Region: SnoaL_2; pfam12680 1097669009065 hypothetical protein; Provisional; Region: PRK06541 1097669009066 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1097669009067 inhibitor-cofactor binding pocket; inhibition site 1097669009068 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1097669009069 catalytic residue [active] 1097669009070 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1097669009071 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1097669009072 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 1097669009073 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1097669009074 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1097669009075 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1097669009076 active site 1097669009077 dimer interface [polypeptide binding]; other site 1097669009078 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1097669009079 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 1097669009080 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1097669009081 DNA binding residues [nucleotide binding] 1097669009082 dimer interface [polypeptide binding]; other site 1097669009083 metal binding site [ion binding]; metal-binding site 1097669009084 inner membrane protein YhjD; Region: TIGR00766 1097669009085 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1097669009086 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1097669009087 active site 1097669009088 HIGH motif; other site 1097669009089 dimer interface [polypeptide binding]; other site 1097669009090 KMSKS motif; other site 1097669009091 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1097669009092 acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875 1097669009093 isocitrate dehydrogenase; Validated; Region: PRK08299 1097669009094 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 1097669009095 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1097669009096 homodimer interface [polypeptide binding]; other site 1097669009097 substrate-cofactor binding pocket; other site 1097669009098 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1097669009099 catalytic residue [active] 1097669009100 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 1097669009101 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 1097669009102 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1097669009103 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1097669009104 S-adenosylmethionine binding site [chemical binding]; other site 1097669009105 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 1097669009106 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 1097669009107 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1097669009108 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1097669009109 homodimer interface [polypeptide binding]; other site 1097669009110 NADP binding site [chemical binding]; other site 1097669009111 substrate binding site [chemical binding]; other site 1097669009112 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 1097669009113 Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769 1097669009114 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1097669009115 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 1097669009116 active site 1097669009117 FMN binding site [chemical binding]; other site 1097669009118 substrate binding site [chemical binding]; other site 1097669009119 putative catalytic residue [active] 1097669009120 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1097669009121 phosphate binding site [ion binding]; other site 1097669009122 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1097669009123 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1097669009124 phosphopeptide binding site; other site 1097669009125 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1097669009126 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1097669009127 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1097669009128 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1097669009129 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1097669009130 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 1097669009131 G1 box; other site 1097669009132 GTP/Mg2+ binding site [chemical binding]; other site 1097669009133 G2 box; other site 1097669009134 Switch I region; other site 1097669009135 G3 box; other site 1097669009136 Switch II region; other site 1097669009137 G4 box; other site 1097669009138 G5 box; other site 1097669009139 Protein of unknown function (DUF742); Region: DUF742; pfam05331 1097669009140 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 1097669009141 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1097669009142 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1097669009143 ATP binding site [chemical binding]; other site 1097669009144 Mg2+ binding site [ion binding]; other site 1097669009145 G-X-G motif; other site 1097669009146 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1097669009147 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 1097669009148 FMN binding site [chemical binding]; other site 1097669009149 dimer interface [polypeptide binding]; other site 1097669009150 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1097669009151 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 1097669009152 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1097669009153 active site 1097669009154 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1097669009155 generic binding surface II; other site 1097669009156 generic binding surface I; other site 1097669009157 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1097669009158 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1097669009159 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1097669009160 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 1097669009161 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1097669009162 active site 1097669009163 motif I; other site 1097669009164 motif II; other site 1097669009165 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1097669009166 substrate binding site [chemical binding]; other site 1097669009167 oxyanion hole (OAH) forming residues; other site 1097669009168 trimer interface [polypeptide binding]; other site 1097669009169 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 1097669009170 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1097669009171 Amidase; Region: Amidase; pfam01425 1097669009172 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1097669009173 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1097669009174 motif II; other site 1097669009175 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 1097669009176 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 1097669009177 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1097669009178 TPP-binding site [chemical binding]; other site 1097669009179 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 1097669009180 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1097669009181 PYR/PP interface [polypeptide binding]; other site 1097669009182 dimer interface [polypeptide binding]; other site 1097669009183 TPP binding site [chemical binding]; other site 1097669009184 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1097669009185 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1097669009186 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1097669009187 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1097669009188 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1097669009189 substrate binding pocket [chemical binding]; other site 1097669009190 chain length determination region; other site 1097669009191 substrate-Mg2+ binding site; other site 1097669009192 catalytic residues [active] 1097669009193 aspartate-rich region 1; other site 1097669009194 active site lid residues [active] 1097669009195 aspartate-rich region 2; other site 1097669009196 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 1097669009197 putative active site [active] 1097669009198 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1097669009199 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 1097669009200 Transposase domain (DUF772); Region: DUF772; pfam05598 1097669009201 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 1097669009202 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1097669009203 enoyl-CoA hydratase; Region: PLN02864 1097669009204 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1097669009205 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 1097669009206 dimer interaction site [polypeptide binding]; other site 1097669009207 substrate-binding tunnel; other site 1097669009208 active site 1097669009209 catalytic site [active] 1097669009210 substrate binding site [chemical binding]; other site 1097669009211 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1097669009212 short chain dehydrogenase; Provisional; Region: PRK07201 1097669009213 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 1097669009214 putative NAD(P) binding site [chemical binding]; other site 1097669009215 active site 1097669009216 putative substrate binding site [chemical binding]; other site 1097669009217 classical (c) SDRs; Region: SDR_c; cd05233 1097669009218 NAD(P) binding site [chemical binding]; other site 1097669009219 active site 1097669009220 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1097669009221 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1097669009222 S-adenosylmethionine binding site [chemical binding]; other site 1097669009223 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 1097669009224 active site 1097669009225 DNA Polymerase Y-family; Region: PolY_like; cd03468 1097669009226 DNA binding site [nucleotide binding] 1097669009227 GMP synthase; Reviewed; Region: guaA; PRK00074 1097669009228 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1097669009229 AMP/PPi binding site [chemical binding]; other site 1097669009230 candidate oxyanion hole; other site 1097669009231 catalytic triad [active] 1097669009232 potential glutamine specificity residues [chemical binding]; other site 1097669009233 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1097669009234 ATP Binding subdomain [chemical binding]; other site 1097669009235 Ligand Binding sites [chemical binding]; other site 1097669009236 Dimerization subdomain; other site 1097669009237 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 1097669009238 active site lid residues [active] 1097669009239 substrate binding pocket [chemical binding]; other site 1097669009240 catalytic residues [active] 1097669009241 substrate-Mg2+ binding site; other site 1097669009242 aspartate-rich region 1; other site 1097669009243 aspartate-rich region 2; other site 1097669009244 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1097669009245 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1097669009246 substrate binding pocket [chemical binding]; other site 1097669009247 chain length determination region; other site 1097669009248 substrate-Mg2+ binding site; other site 1097669009249 catalytic residues [active] 1097669009250 aspartate-rich region 1; other site 1097669009251 active site lid residues [active] 1097669009252 aspartate-rich region 2; other site 1097669009253 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1097669009254 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1097669009255 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 1097669009256 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 1097669009257 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 1097669009258 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1097669009259 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1097669009260 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 1097669009261 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1097669009262 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1097669009263 inhibitor-cofactor binding pocket; inhibition site 1097669009264 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1097669009265 catalytic residue [active] 1097669009266 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 1097669009267 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1097669009268 hypothetical protein; Provisional; Region: PRK07579 1097669009269 Formyltransferase, catalytic core domain; Region: FMT_core; cd08369 1097669009270 active site 1097669009271 cosubstrate binding site; other site 1097669009272 substrate binding site [chemical binding]; other site 1097669009273 catalytic site [active] 1097669009274 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1097669009275 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1097669009276 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1097669009277 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1097669009278 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1097669009279 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 1097669009280 putative active site [active] 1097669009281 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1097669009282 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1097669009283 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1097669009284 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 1097669009285 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1097669009286 phosphate binding site [ion binding]; other site 1097669009287 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1097669009288 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1097669009289 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1097669009290 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1097669009291 active site 1097669009292 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 1097669009293 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1097669009294 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1097669009295 DNA binding residues [nucleotide binding] 1097669009296 Transcription factor WhiB; Region: Whib; pfam02467 1097669009297 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1097669009298 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1097669009299 ring oligomerisation interface [polypeptide binding]; other site 1097669009300 ATP/Mg binding site [chemical binding]; other site 1097669009301 stacking interactions; other site 1097669009302 hinge regions; other site 1097669009303 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1097669009304 oligomerisation interface [polypeptide binding]; other site 1097669009305 mobile loop; other site 1097669009306 roof hairpin; other site 1097669009307 UGMP family protein; Validated; Region: PRK09604 1097669009308 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1097669009309 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1097669009310 Coenzyme A binding pocket [chemical binding]; other site 1097669009311 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 1097669009312 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; pfam02367 1097669009313 alanine racemase; Reviewed; Region: alr; PRK00053 1097669009314 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1097669009315 active site 1097669009316 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1097669009317 dimer interface [polypeptide binding]; other site 1097669009318 substrate binding site [chemical binding]; other site 1097669009319 catalytic residues [active] 1097669009320 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1097669009321 PPE family; Region: PPE; pfam00823 1097669009322 Integrase core domain; Region: rve; pfam00665 1097669009323 Integrase core domain; Region: rve_3; pfam13683 1097669009324 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1097669009325 MULE transposase domain; Region: MULE; pfam10551 1097669009326 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 1097669009327 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1097669009328 catalytic residue [active] 1097669009329 Uncharacterized conserved protein [Function unknown]; Region: COG0062 1097669009330 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1097669009331 putative substrate binding site [chemical binding]; other site 1097669009332 putative ATP binding site [chemical binding]; other site 1097669009333 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1097669009334 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1097669009335 glutaminase active site [active] 1097669009336 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1097669009337 dimer interface [polypeptide binding]; other site 1097669009338 active site 1097669009339 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1097669009340 dimer interface [polypeptide binding]; other site 1097669009341 active site 1097669009342 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 1097669009343 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 1097669009344 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1097669009345 active site 1097669009346 substrate binding site [chemical binding]; other site 1097669009347 metal binding site [ion binding]; metal-binding site 1097669009348 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1097669009349 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1097669009350 23S rRNA interface [nucleotide binding]; other site 1097669009351 L3 interface [polypeptide binding]; other site 1097669009352 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1097669009353 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1097669009354 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 1097669009355 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1097669009356 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1097669009357 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1097669009358 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1097669009359 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1097669009360 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 1097669009361 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 1097669009362 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1097669009363 active site 1097669009364 catalytic residues [active] 1097669009365 Protein of unknown function (DUF690); Region: DUF690; pfam05108 1097669009366 Cutinase; Region: Cutinase; pfam01083 1097669009367 Cutinase; Region: Cutinase; pfam01083 1097669009368 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1097669009369 Pseudouridylate synthase [Translation, ribosomal structure and biogenesis]; Region: TruA; COG0101 1097669009370 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1097669009371 dimerization interface 3.5A [polypeptide binding]; other site 1097669009372 active site 1097669009373 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1097669009374 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1097669009375 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1097669009376 alphaNTD - beta interaction site [polypeptide binding]; other site 1097669009377 alphaNTD homodimer interface [polypeptide binding]; other site 1097669009378 alphaNTD - beta' interaction site [polypeptide binding]; other site 1097669009379 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1097669009380 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1097669009381 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1097669009382 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1097669009383 RNA binding surface [nucleotide binding]; other site 1097669009384 30S ribosomal protein S11; Validated; Region: PRK05309 1097669009385 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1097669009386 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1097669009387 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 1097669009388 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1097669009389 rRNA binding site [nucleotide binding]; other site 1097669009390 predicted 30S ribosome binding site; other site 1097669009391 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 1097669009392 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 1097669009393 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1097669009394 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1097669009395 NAD binding site [chemical binding]; other site 1097669009396 substrate binding site [chemical binding]; other site 1097669009397 homodimer interface [polypeptide binding]; other site 1097669009398 active site 1097669009399 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 1097669009400 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1097669009401 extended (e) SDRs; Region: SDR_e; cd08946 1097669009402 NAD(P) binding site [chemical binding]; other site 1097669009403 active site 1097669009404 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 1097669009405 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 1097669009406 active site 1097669009407 catalytic residues [active] 1097669009408 metal binding site [ion binding]; metal-binding site 1097669009409 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 1097669009410 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1097669009411 PYR/PP interface [polypeptide binding]; other site 1097669009412 dimer interface [polypeptide binding]; other site 1097669009413 TPP binding site [chemical binding]; other site 1097669009414 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1097669009415 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1097669009416 TPP-binding site [chemical binding]; other site 1097669009417 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 1097669009418 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 1097669009419 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1097669009420 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1097669009421 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1097669009422 metabolite-proton symporter; Region: 2A0106; TIGR00883 1097669009423 putative substrate translocation pore; other site 1097669009424 PE family; Region: PE; pfam00934 1097669009425 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1097669009426 PPE family; Region: PPE; pfam00823 1097669009427 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1097669009428 patatin-related protein; Region: TIGR03607 1097669009429 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1097669009430 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1097669009431 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 1097669009432 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 1097669009433 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 1097669009434 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 1097669009435 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1097669009436 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1097669009437 short chain dehydrogenase; Provisional; Region: PRK05875 1097669009438 classical (c) SDRs; Region: SDR_c; cd05233 1097669009439 NAD(P) binding site [chemical binding]; other site 1097669009440 active site 1097669009441 Predicted membrane protein [Function unknown]; Region: COG2259 1097669009442 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1097669009443 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1097669009444 Predicted transcriptional regulators [Transcription]; Region: COG1695 1097669009445 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1097669009446 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 1097669009447 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 1097669009448 active site 1097669009449 homotetramer interface [polypeptide binding]; other site 1097669009450 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1097669009451 mce related protein; Region: MCE; pfam02470 1097669009452 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1097669009453 mce related protein; Region: MCE; pfam02470 1097669009454 mce related protein; Region: MCE; pfam02470 1097669009455 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1097669009456 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1097669009457 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1097669009458 mce related protein; Region: MCE; pfam02470 1097669009459 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1097669009460 mce related protein; Region: MCE; pfam02470 1097669009461 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1097669009462 mce related protein; Region: MCE; pfam02470 1097669009463 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1097669009464 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1097669009465 Permease; Region: Permease; pfam02405 1097669009466 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1097669009467 Permease; Region: Permease; pfam02405 1097669009468 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07792 1097669009469 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1097669009470 NAD(P) binding site [chemical binding]; other site 1097669009471 active site 1097669009472 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1097669009473 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 1097669009474 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1097669009475 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 1097669009476 FAD binding site [chemical binding]; other site 1097669009477 substrate binding site [chemical binding]; other site 1097669009478 catalytic base [active] 1097669009479 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1097669009480 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1097669009481 active site 1097669009482 acyl-CoA synthetase; Validated; Region: PRK07867 1097669009483 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 1097669009484 acyl-activating enzyme (AAE) consensus motif; other site 1097669009485 putative AMP binding site [chemical binding]; other site 1097669009486 putative active site [active] 1097669009487 putative CoA binding site [chemical binding]; other site 1097669009488 hypothetical protein; Validated; Region: PRK07586 1097669009489 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1097669009490 PYR/PP interface [polypeptide binding]; other site 1097669009491 dimer interface [polypeptide binding]; other site 1097669009492 TPP binding site [chemical binding]; other site 1097669009493 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 1097669009494 TPP-binding site [chemical binding]; other site 1097669009495 dimer interface [polypeptide binding]; other site 1097669009496 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 1097669009497 enoyl-CoA hydratase; Provisional; Region: PRK07799 1097669009498 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1097669009499 substrate binding site [chemical binding]; other site 1097669009500 oxyanion hole (OAH) forming residues; other site 1097669009501 trimer interface [polypeptide binding]; other site 1097669009502 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1097669009503 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1097669009504 Cytochrome P450; Region: p450; cl12078 1097669009505 Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314 1097669009506 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1097669009507 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 1097669009508 DUF35 OB-fold domain; Region: DUF35; pfam01796 1097669009509 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1097669009510 DUF35 OB-fold domain; Region: DUF35; pfam01796 1097669009511 lipid-transfer protein; Provisional; Region: PRK07937 1097669009512 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1097669009513 active site 1097669009514 acetyl-CoA acetyltransferase; Provisional; Region: PRK08313 1097669009515 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1097669009516 active site 1097669009517 NHL repeat; Region: NHL; pfam01436 1097669009518 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1097669009519 NHL repeat; Region: NHL; pfam01436 1097669009520 NHL repeat; Region: NHL; pfam01436 1097669009521 NHL repeat; Region: NHL; pfam01436 1097669009522 NHL repeat; Region: NHL; pfam01436 1097669009523 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1097669009524 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1097669009525 trimer interface [polypeptide binding]; other site 1097669009526 putative metal binding site [ion binding]; other site 1097669009527 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1097669009528 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 1097669009529 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 1097669009530 short chain dehydrogenase; Provisional; Region: PRK07890 1097669009531 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1097669009532 NAD(P) binding site [chemical binding]; other site 1097669009533 active site 1097669009534 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1097669009535 PPE family; Region: PPE; pfam00823 1097669009536 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1097669009537 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1097669009538 PPE family; Region: PPE; pfam00823 1097669009539 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1097669009540 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1097669009541 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 1097669009542 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 1097669009543 active site 1097669009544 catalytic residues [active] 1097669009545 metal binding site [ion binding]; metal-binding site 1097669009546 DmpG-like communication domain; Region: DmpG_comm; pfam07836 1097669009547 acetaldehyde dehydrogenase; Validated; Region: PRK08300 1097669009548 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1097669009549 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 1097669009550 2-keto-4-pentenoate hydratase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3971 1097669009551 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843 1097669009552 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1097669009553 enoyl-CoA hydratase; Region: PLN02864 1097669009554 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1097669009555 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 1097669009556 dimer interaction site [polypeptide binding]; other site 1097669009557 substrate-binding tunnel; other site 1097669009558 active site 1097669009559 catalytic site [active] 1097669009560 substrate binding site [chemical binding]; other site 1097669009561 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1097669009562 PPE family; Region: PPE; pfam00823 1097669009563 PE-PPE domain; Region: PE-PPE; pfam08237 1097669009564 lipid-transfer protein; Provisional; Region: PRK07855 1097669009565 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1097669009566 active site 1097669009567 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 1097669009568 putative active site [active] 1097669009569 putative catalytic site [active] 1097669009570 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1097669009571 active site 1097669009572 catalytic site [active] 1097669009573 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1097669009574 DUF35 OB-fold domain; Region: DUF35; pfam01796 1097669009575 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1097669009576 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1097669009577 active site 1097669009578 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1097669009579 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1097669009580 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1097669009581 active site 1097669009582 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1097669009583 Cytochrome P450; Region: p450; cl12078 1097669009584 acetyl-CoA acetyltransferase; Provisional; Region: PRK07850 1097669009585 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1097669009586 dimer interface [polypeptide binding]; other site 1097669009587 active site 1097669009588 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1097669009589 short chain dehydrogenase; Provisional; Region: PRK07791 1097669009590 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 1097669009591 homodimer interface [polypeptide binding]; other site 1097669009592 NAD binding site [chemical binding]; other site 1097669009593 active site 1097669009594 short chain dehydrogenase; Provisional; Region: PRK07856 1097669009595 classical (c) SDRs; Region: SDR_c; cd05233 1097669009596 NAD(P) binding site [chemical binding]; other site 1097669009597 active site 1097669009598 enoyl-CoA hydratase; Provisional; Region: PRK06495 1097669009599 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1097669009600 substrate binding site [chemical binding]; other site 1097669009601 oxyanion hole (OAH) forming residues; other site 1097669009602 trimer interface [polypeptide binding]; other site 1097669009603 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1097669009604 Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit [Lipid metabolism]; Region: AtoA; COG2057 1097669009605 Nitronate monooxygenase; Region: NMO; pfam03060 1097669009606 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1097669009607 FMN binding site [chemical binding]; other site 1097669009608 substrate binding site [chemical binding]; other site 1097669009609 putative catalytic residue [active] 1097669009610 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1097669009611 Beta-carotene hydroxylase (CrtR), the carotenoid zeaxanthin biosynthetic enzyme catalyzes the addition of hydroxyl groups to the beta-ionone rings of beta-carotene to form zeaxanthin and is found in bacteria and red algae. Carotenoids are important...; Region: CrtR_beta-carotene-hydroxylase; cd03514 1097669009612 putative di-iron ligands [ion binding]; other site 1097669009613 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 1097669009614 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 1097669009615 FAD binding pocket [chemical binding]; other site 1097669009616 FAD binding motif [chemical binding]; other site 1097669009617 phosphate binding motif [ion binding]; other site 1097669009618 beta-alpha-beta structure motif; other site 1097669009619 NAD(p) ribose binding residues [chemical binding]; other site 1097669009620 NAD binding pocket [chemical binding]; other site 1097669009621 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 1097669009622 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1097669009623 catalytic loop [active] 1097669009624 iron binding site [ion binding]; other site 1097669009625 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1097669009626 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1097669009627 putative active site [active] 1097669009628 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 1097669009629 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1097669009630 dimer interface [polypeptide binding]; other site 1097669009631 active site 1097669009632 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1097669009633 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1097669009634 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1097669009635 PPE family; Region: PPE; pfam00823 1097669009636 short chain dehydrogenase; Provisional; Region: PRK07831 1097669009637 classical (c) SDRs; Region: SDR_c; cd05233 1097669009638 NAD(P) binding site [chemical binding]; other site 1097669009639 active site 1097669009640 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1097669009641 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1097669009642 active site 1097669009643 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 1097669009644 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1097669009645 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 1097669009646 acyl-activating enzyme (AAE) consensus motif; other site 1097669009647 putative AMP binding site [chemical binding]; other site 1097669009648 putative active site [active] 1097669009649 putative CoA binding site [chemical binding]; other site 1097669009650 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1097669009651 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1097669009652 active site 1097669009653 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1097669009654 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1097669009655 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1097669009656 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1097669009657 active site 1097669009658 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1097669009659 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1097669009660 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1097669009661 active site 1097669009662 aspartate aminotransferase; Provisional; Region: PRK05764 1097669009663 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1097669009664 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1097669009665 homodimer interface [polypeptide binding]; other site 1097669009666 catalytic residue [active] 1097669009667 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 1097669009668 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1097669009669 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 1097669009670 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 1097669009671 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 1097669009672 active site 1097669009673 Fe binding site [ion binding]; other site 1097669009674 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 1097669009675 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1097669009676 Naphthocyclinone hydroxylase; Region: NcnH; cd01159 1097669009677 Flavin binding site [chemical binding]; other site 1097669009678 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1097669009679 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 1097669009680 FAD binding pocket [chemical binding]; other site 1097669009681 FAD binding motif [chemical binding]; other site 1097669009682 phosphate binding motif [ion binding]; other site 1097669009683 beta-alpha-beta structure motif; other site 1097669009684 NAD(p) ribose binding residues [chemical binding]; other site 1097669009685 NAD binding pocket [chemical binding]; other site 1097669009686 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 1097669009687 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1097669009688 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1097669009689 catalytic loop [active] 1097669009690 iron binding site [ion binding]; other site 1097669009691 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1097669009692 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1097669009693 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1097669009694 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1097669009695 active site 1097669009696 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1097669009697 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1097669009698 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1097669009699 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1097669009700 DNA binding site [nucleotide binding] 1097669009701 domain linker motif; other site 1097669009702 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 1097669009703 putative dimerization interface [polypeptide binding]; other site 1097669009704 putative ligand binding site [chemical binding]; other site 1097669009705 PknH-like extracellular domain; Region: PknH_C; pfam14032 1097669009706 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1097669009707 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1097669009708 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1097669009709 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1097669009710 transmembrane helices; other site 1097669009711 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1097669009712 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1097669009713 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1097669009714 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1097669009715 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1097669009716 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1097669009717 active site 1097669009718 HIGH motif; other site 1097669009719 nucleotide binding site [chemical binding]; other site 1097669009720 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1097669009721 KMSKS motif; other site 1097669009722 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1097669009723 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1097669009724 homotrimer interaction site [polypeptide binding]; other site 1097669009725 zinc binding site [ion binding]; other site 1097669009726 CDP-binding sites; other site 1097669009727 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1097669009728 substrate binding site; other site 1097669009729 dimer interface; other site 1097669009730 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 1097669009731 DNA repair protein RadA; Provisional; Region: PRK11823 1097669009732 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1097669009733 Walker A motif/ATP binding site; other site 1097669009734 ATP binding site [chemical binding]; other site 1097669009735 Walker B motif; other site 1097669009736 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1097669009737 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 1097669009738 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1097669009739 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 1097669009740 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 1097669009741 active site clefts [active] 1097669009742 zinc binding site [ion binding]; other site 1097669009743 dimer interface [polypeptide binding]; other site 1097669009744 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1097669009745 endonuclease III; Region: ENDO3c; smart00478 1097669009746 minor groove reading motif; other site 1097669009747 helix-hairpin-helix signature motif; other site 1097669009748 substrate binding pocket [chemical binding]; other site 1097669009749 active site 1097669009750 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1097669009751 PE family; Region: PE; pfam00934 1097669009752 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1097669009753 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1097669009754 catalytic site [active] 1097669009755 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1097669009756 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 1097669009757 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1097669009758 Ami_2 domain; Region: Ami_2; smart00644 1097669009759 amidase catalytic site [active] 1097669009760 Zn binding residues [ion binding]; other site 1097669009761 substrate binding site [chemical binding]; other site 1097669009762 PE family; Region: PE; pfam00934 1097669009763 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1097669009764 Clp amino terminal domain; Region: Clp_N; pfam02861 1097669009765 Clp amino terminal domain; Region: Clp_N; pfam02861 1097669009766 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1097669009767 Walker A motif; other site 1097669009768 ATP binding site [chemical binding]; other site 1097669009769 Walker B motif; other site 1097669009770 arginine finger; other site 1097669009771 UvrB/uvrC motif; Region: UVR; pfam02151 1097669009772 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1097669009773 Walker A motif; other site 1097669009774 ATP binding site [chemical binding]; other site 1097669009775 Walker B motif; other site 1097669009776 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1097669009777 Lsr2; Region: Lsr2; pfam11774 1097669009778 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1097669009779 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1097669009780 dimer interface [polypeptide binding]; other site 1097669009781 putative anticodon binding site; other site 1097669009782 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1097669009783 motif 1; other site 1097669009784 dimer interface [polypeptide binding]; other site 1097669009785 active site 1097669009786 motif 2; other site 1097669009787 motif 3; other site 1097669009788 pantothenate kinase; Reviewed; Region: PRK13318 1097669009789 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1097669009790 tetramerization interface [polypeptide binding]; other site 1097669009791 active site 1097669009792 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1097669009793 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1097669009794 active site 1097669009795 ATP-binding site [chemical binding]; other site 1097669009796 pantoate-binding site; other site 1097669009797 HXXH motif; other site 1097669009798 Rossmann-like domain; Region: Rossmann-like; pfam10727 1097669009799 Uncharacterized conserved protein [Function unknown]; Region: COG5495 1097669009800 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 1097669009801 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 1097669009802 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1097669009803 catalytic center binding site [active] 1097669009804 ATP binding site [chemical binding]; other site 1097669009805 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1097669009806 homooctamer interface [polypeptide binding]; other site 1097669009807 active site 1097669009808 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1097669009809 dihydropteroate synthase; Region: DHPS; TIGR01496 1097669009810 substrate binding pocket [chemical binding]; other site 1097669009811 dimer interface [polypeptide binding]; other site 1097669009812 inhibitor binding site; inhibition site 1097669009813 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1097669009814 homodecamer interface [polypeptide binding]; other site 1097669009815 GTP cyclohydrolase I; Provisional; Region: PLN03044 1097669009816 active site 1097669009817 putative catalytic site residues [active] 1097669009818 zinc binding site [ion binding]; other site 1097669009819 GTP-CH-I/GFRP interaction surface; other site 1097669009820 FtsH Extracellular; Region: FtsH_ext; pfam06480 1097669009821 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1097669009822 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1097669009823 Walker A motif; other site 1097669009824 ATP binding site [chemical binding]; other site 1097669009825 Walker B motif; other site 1097669009826 arginine finger; other site 1097669009827 Peptidase family M41; Region: Peptidase_M41; pfam01434 1097669009828 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 1097669009829 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1097669009830 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1097669009831 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1097669009832 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1097669009833 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1097669009834 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1097669009835 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1097669009836 PPE family; Region: PPE; pfam00823 1097669009837 PE family; Region: PE; pfam00934 1097669009838 Uncharacterized conserved protein [Function unknown]; Region: COG2968 1097669009839 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 1097669009840 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1097669009841 active site 1097669009842 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1097669009843 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1097669009844 Ligand Binding Site [chemical binding]; other site 1097669009845 Uncharacterized conserved protein [Function unknown]; Region: COG5282 1097669009846 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 1097669009847 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; pfam02113 1097669009848 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 1097669009849 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1097669009850 dimer interface [polypeptide binding]; other site 1097669009851 substrate binding site [chemical binding]; other site 1097669009852 metal binding sites [ion binding]; metal-binding site 1097669009853 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2899 1097669009854 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1097669009855 Ligand binding site; other site 1097669009856 Putative Catalytic site; other site 1097669009857 DXD motif; other site 1097669009858 Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034 1097669009859 Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5285 1097669009860 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1097669009861 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1097669009862 NAD(P) binding site [chemical binding]; other site 1097669009863 active site 1097669009864 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1097669009865 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 1097669009866 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1097669009867 transposase; Provisional; Region: PRK06526 1097669009868 IstB-like ATP binding protein; Region: IstB_IS21; pfam01695 1097669009869 Walker B motif; other site 1097669009870 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1097669009871 MULE transposase domain; Region: MULE; pfam10551 1097669009872 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 1097669009873 Fic/DOC family; Region: Fic; cl00960 1097669009874 VbhA antitoxin and related proteins; Region: VbhA_like; cd11586 1097669009875 DNA polymerase III subunit delta'; Validated; Region: PRK07940 1097669009876 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1097669009877 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1097669009878 dimerization interface [polypeptide binding]; other site 1097669009879 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1097669009880 cyclase homology domain; Region: CHD; cd07302 1097669009881 nucleotidyl binding site; other site 1097669009882 metal binding site [ion binding]; metal-binding site 1097669009883 dimer interface [polypeptide binding]; other site 1097669009884 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 1097669009885 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1097669009886 active site 1097669009887 interdomain interaction site; other site 1097669009888 putative metal-binding site [ion binding]; other site 1097669009889 nucleotide binding site [chemical binding]; other site 1097669009890 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 1097669009891 domain I; other site 1097669009892 phosphate binding site [ion binding]; other site 1097669009893 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1097669009894 domain II; other site 1097669009895 domain III; other site 1097669009896 nucleotide binding site [chemical binding]; other site 1097669009897 DNA binding groove [nucleotide binding] 1097669009898 catalytic site [active] 1097669009899 domain IV; other site 1097669009900 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1097669009901 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1097669009902 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1097669009903 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1097669009904 DNA-binding site [nucleotide binding]; DNA binding site 1097669009905 RNA-binding motif; other site 1097669009906 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 1097669009907 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1097669009908 ATP binding site [chemical binding]; other site 1097669009909 putative Mg++ binding site [ion binding]; other site 1097669009910 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1097669009911 nucleotide binding region [chemical binding]; other site 1097669009912 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 1097669009913 PE family; Region: PE; pfam00934 1097669009914 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 1097669009915 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 1097669009916 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 1097669009917 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 1097669009918 Walker A motif; other site 1097669009919 hexamer interface [polypeptide binding]; other site 1097669009920 ATP binding site [chemical binding]; other site 1097669009921 Walker B motif; other site 1097669009922 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 1097669009923 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1097669009924 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1097669009925 motif II; other site 1097669009926 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1097669009927 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1097669009928 Walker A/P-loop; other site 1097669009929 ATP binding site [chemical binding]; other site 1097669009930 Q-loop/lid; other site 1097669009931 ABC transporter signature motif; other site 1097669009932 Walker B; other site 1097669009933 D-loop; other site 1097669009934 H-loop/switch region; other site 1097669009935 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1097669009936 Walker A/P-loop; other site 1097669009937 ATP binding site [chemical binding]; other site 1097669009938 Q-loop/lid; other site 1097669009939 ABC transporter signature motif; other site 1097669009940 Walker B; other site 1097669009941 D-loop; other site 1097669009942 H-loop/switch region; other site 1097669009943 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1097669009944 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1097669009945 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1097669009946 ABC-ATPase subunit interface; other site 1097669009947 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1097669009948 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1097669009949 dimer interface [polypeptide binding]; other site 1097669009950 conserved gate region; other site 1097669009951 ABC-ATPase subunit interface; other site 1097669009952 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1097669009953 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1097669009954 acetyl-CoA synthetase; Provisional; Region: PRK00174 1097669009955 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1097669009956 active site 1097669009957 CoA binding site [chemical binding]; other site 1097669009958 acyl-activating enzyme (AAE) consensus motif; other site 1097669009959 AMP binding site [chemical binding]; other site 1097669009960 acetate binding site [chemical binding]; other site 1097669009961 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 1097669009962 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1097669009963 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1097669009964 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1097669009965 putative active site [active] 1097669009966 putative CoA binding site [chemical binding]; other site 1097669009967 nudix motif; other site 1097669009968 metal binding site [ion binding]; metal-binding site 1097669009969 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1097669009970 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1097669009971 catalytic residues [active] 1097669009972 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1097669009973 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1097669009974 minor groove reading motif; other site 1097669009975 helix-hairpin-helix signature motif; other site 1097669009976 substrate binding pocket [chemical binding]; other site 1097669009977 active site 1097669009978 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1097669009979 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1097669009980 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1097669009981 ligand binding site [chemical binding]; other site 1097669009982 flexible hinge region; other site 1097669009983 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1097669009984 putative switch regulator; other site 1097669009985 non-specific DNA interactions [nucleotide binding]; other site 1097669009986 DNA binding site [nucleotide binding] 1097669009987 sequence specific DNA binding site [nucleotide binding]; other site 1097669009988 putative cAMP binding site [chemical binding]; other site 1097669009989 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1097669009990 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 1097669009991 homotrimer interaction site [polypeptide binding]; other site 1097669009992 putative active site [active] 1097669009993 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 1097669009994 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 1097669009995 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1097669009996 P loop; other site 1097669009997 Nucleotide binding site [chemical binding]; other site 1097669009998 DTAP/Switch II; other site 1097669009999 Transcription factor WhiB; Region: Whib; pfam02467 1097669010000 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1097669010001 Transglycosylase; Region: Transgly; pfam00912 1097669010002 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1097669010003 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1097669010004 phosphodiesterase YaeI; Provisional; Region: PRK11340 1097669010005 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1097669010006 putative active site [active] 1097669010007 putative metal binding site [ion binding]; other site 1097669010008 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1097669010009 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1097669010010 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1097669010011 catalytic residue [active] 1097669010012 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1097669010013 Cytochrome P450; Region: p450; cl12078 1097669010014 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1097669010015 anti sigma factor interaction site; other site 1097669010016 regulatory phosphorylation site [posttranslational modification]; other site 1097669010017 Uncharacterized conserved protein [Function unknown]; Region: COG1610 1097669010018 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 1097669010019 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 1097669010020 MoxR-like ATPases [General function prediction only]; Region: COG0714 1097669010021 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1097669010022 Walker A motif; other site 1097669010023 ATP binding site [chemical binding]; other site 1097669010024 Walker B motif; other site 1097669010025 arginine finger; other site 1097669010026 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1097669010027 Protein of unknown function DUF58; Region: DUF58; pfam01882 1097669010028 Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300 1097669010029 Predicted membrane protein/domain [Function unknown]; Region: COG1714 1097669010030 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1097669010031 nucleotide binding site [chemical binding]; other site 1097669010032 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 1097669010033 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 1097669010034 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1097669010035 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1097669010036 S-adenosylmethionine binding site [chemical binding]; other site 1097669010037 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1097669010038 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1097669010039 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1097669010040 catalytic residue [active] 1097669010041 Uncharacterized conserved protein [Function unknown]; Region: COG4301 1097669010042 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 1097669010043 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 1097669010044 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1097669010045 putative active site [active] 1097669010046 putative dimer interface [polypeptide binding]; other site 1097669010047 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 1097669010048 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1097669010049 Gamma-glutamylcysteine synthetase [Coenzyme metabolism]; Region: GshA; COG3572 1097669010050 PknH-like extracellular domain; Region: PknH_C; pfam14032 1097669010051 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 1097669010052 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1097669010053 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1097669010054 aspartate kinase; Reviewed; Region: PRK06635 1097669010055 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1097669010056 putative nucleotide binding site [chemical binding]; other site 1097669010057 putative catalytic residues [active] 1097669010058 putative Mg ion binding site [ion binding]; other site 1097669010059 putative aspartate binding site [chemical binding]; other site 1097669010060 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1097669010061 putative allosteric regulatory site; other site 1097669010062 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1097669010063 putative allosteric regulatory residue; other site 1097669010064 2-isopropylmalate synthase; Validated; Region: PRK03739 1097669010065 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 1097669010066 active site 1097669010067 catalytic residues [active] 1097669010068 metal binding site [ion binding]; metal-binding site 1097669010069 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1097669010070 DNA polymerase III subunit epsilon; Provisional; Region: PRK06063 1097669010071 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1097669010072 active site 1097669010073 catalytic site [active] 1097669010074 substrate binding site [chemical binding]; other site 1097669010075 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 1097669010076 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 1097669010077 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1097669010078 catalytic triad [active] 1097669010079 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1097669010080 putative active site [active] 1097669010081 recombination protein RecR; Reviewed; Region: recR; PRK00076 1097669010082 RecR protein; Region: RecR; pfam02132 1097669010083 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1097669010084 putative active site [active] 1097669010085 putative metal-binding site [ion binding]; other site 1097669010086 tetramer interface [polypeptide binding]; other site 1097669010087 hypothetical protein; Validated; Region: PRK00153 1097669010088 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1097669010089 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1097669010090 active site 1097669010091 metal binding site [ion binding]; metal-binding site 1097669010092 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 1097669010093 hydrophobic ligand binding site; other site 1097669010094 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1097669010095 FAD binding domain; Region: FAD_binding_4; pfam01565 1097669010096 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1097669010097 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1097669010098 S-adenosylmethionine binding site [chemical binding]; other site 1097669010099 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14952 1097669010100 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1097669010101 Walker A motif; other site 1097669010102 ATP binding site [chemical binding]; other site 1097669010103 Walker B motif; other site 1097669010104 arginine finger; other site 1097669010105 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1097669010106 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 1097669010107 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1097669010108 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1097669010109 catalytic residue [active] 1097669010110 Cutinase; Region: Cutinase; pfam01083 1097669010111 Cutinase; Region: Cutinase; pfam01083 1097669010112 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1097669010113 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1097669010114 NAD(P) binding site [chemical binding]; other site 1097669010115 active site 1097669010116 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1097669010117 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH8; cd08262 1097669010118 putative NAD(P) binding site [chemical binding]; other site 1097669010119 catalytic Zn binding site [ion binding]; other site 1097669010120 Uncharacterized conserved protein [Function unknown]; Region: COG3349 1097669010121 Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl17487 1097669010122 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1097669010123 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1097669010124 putative substrate translocation pore; other site 1097669010125 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1097669010126 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1097669010127 ligand binding site [chemical binding]; other site 1097669010128 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1097669010129 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 1097669010130 active site 1097669010131 nucleophile elbow; other site 1097669010132 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG1964 1097669010133 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1097669010134 FeS/SAM binding site; other site 1097669010135 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1097669010136 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1097669010137 S-adenosylmethionine binding site [chemical binding]; other site 1097669010138 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 1097669010139 nucleotide binding site [chemical binding]; other site 1097669010140 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 1097669010141 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 1097669010142 active site 1097669010143 DNA binding site [nucleotide binding] 1097669010144 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 1097669010145 DNA binding site [nucleotide binding] 1097669010146 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4402 1097669010147 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_5; cd04662 1097669010148 nudix motif; other site 1097669010149 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1097669010150 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1097669010151 Uncharacterized conserved protein [Function unknown]; Region: COG1839 1097669010152 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1097669010153 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1097669010154 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1097669010155 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1097669010156 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1097669010157 Uncharacterized conserved protein [Function unknown]; Region: COG3610 1097669010158 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1097669010159 PPE family; Region: PPE; pfam00823 1097669010160 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1097669010161 PPE family; Region: PPE; pfam00823 1097669010162 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1097669010163 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1097669010164 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1097669010165 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1097669010166 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 1097669010167 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 1097669010168 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1097669010169 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1097669010170 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1097669010171 dimerization interface [polypeptide binding]; other site 1097669010172 putative DNA binding site [nucleotide binding]; other site 1097669010173 putative Zn2+ binding site [ion binding]; other site 1097669010174 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3651 1097669010175 DNA binding domain, excisionase family; Region: excise; TIGR01764 1097669010176 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1097669010177 active site 1097669010178 Int/Topo IB signature motif; other site 1097669010179 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1097669010180 nucleoside/Zn binding site; other site 1097669010181 dimer interface [polypeptide binding]; other site 1097669010182 catalytic motif [active] 1097669010183 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 1097669010184 prephenate dehydrogenase; Validated; Region: PRK06545 1097669010185 prephenate dehydrogenase; Validated; Region: PRK08507 1097669010186 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3554 1097669010187 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1097669010188 ABC-ATPase subunit interface; other site 1097669010189 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 1097669010190 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1097669010191 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1097669010192 Walker A/P-loop; other site 1097669010193 ATP binding site [chemical binding]; other site 1097669010194 Q-loop/lid; other site 1097669010195 ABC transporter signature motif; other site 1097669010196 Walker B; other site 1097669010197 D-loop; other site 1097669010198 H-loop/switch region; other site 1097669010199 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1097669010200 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 1097669010201 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1097669010202 putative active site [active] 1097669010203 putative substrate binding site [chemical binding]; other site 1097669010204 ATP binding site [chemical binding]; other site 1097669010205 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 1097669010206 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1097669010207 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 1097669010208 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1097669010209 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 1097669010210 dimerization interface [polypeptide binding]; other site 1097669010211 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1097669010212 dimer interface [polypeptide binding]; other site 1097669010213 phosphorylation site [posttranslational modification] 1097669010214 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1097669010215 ATP binding site [chemical binding]; other site 1097669010216 Mg2+ binding site [ion binding]; other site 1097669010217 G-X-G motif; other site 1097669010218 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1097669010219 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1097669010220 active site 1097669010221 phosphorylation site [posttranslational modification] 1097669010222 intermolecular recognition site; other site 1097669010223 dimerization interface [polypeptide binding]; other site 1097669010224 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1097669010225 DNA binding site [nucleotide binding] 1097669010226 Photosystem II reaction centre W protein (PsbW); Region: PsbW; cl06243 1097669010227 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1097669010228 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1097669010229 SnoaL-like domain; Region: SnoaL_2; pfam12680 1097669010230 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 1097669010231 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1097669010232 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1097669010233 homodimer interface [polypeptide binding]; other site 1097669010234 catalytic residue [active] 1097669010235 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1097669010236 TIGR03086 family protein; Region: TIGR03086 1097669010237 enoyl-CoA hydratase; Provisional; Region: PRK06142 1097669010238 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1097669010239 substrate binding site [chemical binding]; other site 1097669010240 oxyanion hole (OAH) forming residues; other site 1097669010241 trimer interface [polypeptide binding]; other site 1097669010242 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1097669010243 Beta-lactamase; Region: Beta-lactamase; pfam00144 1097669010244 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1097669010245 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1097669010246 active site 1097669010247 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 1097669010248 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 1097669010249 NAD(P) binding site [chemical binding]; other site 1097669010250 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1097669010251 cysteine desulfurase family protein, VC1184 subfamily; Region: am_tr_V_VC1184; TIGR01976 1097669010252 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1097669010253 catalytic residue [active] 1097669010254 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 1097669010255 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1097669010256 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1097669010257 Walker A/P-loop; other site 1097669010258 ATP binding site [chemical binding]; other site 1097669010259 Q-loop/lid; other site 1097669010260 ABC transporter signature motif; other site 1097669010261 Walker B; other site 1097669010262 D-loop; other site 1097669010263 H-loop/switch region; other site 1097669010264 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1097669010265 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1097669010266 active site 1097669010267 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1097669010268 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1097669010269 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1097669010270 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 1097669010271 NAD binding site [chemical binding]; other site 1097669010272 substrate binding site [chemical binding]; other site 1097669010273 active site 1097669010274 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1097669010275 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1097669010276 active site 1097669010277 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1097669010278 Peptidase family M23; Region: Peptidase_M23; pfam01551 1097669010279 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1097669010280 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1097669010281 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05892 1097669010282 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1097669010283 Predicted membrane protein [Function unknown]; Region: COG2246 1097669010284 GtrA-like protein; Region: GtrA; pfam04138 1097669010285 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1097669010286 FAD binding domain; Region: FAD_binding_4; pfam01565 1097669010287 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 1097669010288 short chain dehydrogenase; Provisional; Region: PRK07904 1097669010289 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1097669010290 NAD(P) binding site [chemical binding]; other site 1097669010291 active site 1097669010292 Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250 1097669010293 Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249 1097669010294 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 1097669010295 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 1097669010296 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 1097669010297 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1097669010298 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 1097669010299 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1097669010300 FAD binding site [chemical binding]; other site 1097669010301 substrate binding site [chemical binding]; other site 1097669010302 catalytic residues [active] 1097669010303 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1097669010304 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1097669010305 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1097669010306 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1097669010307 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1097669010308 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1097669010309 active site 1097669010310 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1097669010311 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1097669010312 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1097669010313 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1097669010314 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 1097669010315 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1097669010316 acyl-activating enzyme (AAE) consensus motif; other site 1097669010317 active site 1097669010318 Cutinase; Region: Cutinase; pfam01083 1097669010319 Predicted esterase [General function prediction only]; Region: COG0627 1097669010320 Putative esterase; Region: Esterase; pfam00756 1097669010321 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 1097669010322 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 1097669010323 active site 1097669010324 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1097669010325 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1097669010326 active site 1097669010327 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 1097669010328 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1097669010329 UDP-galactopyranose mutase; Region: GLF; pfam03275 1097669010330 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 1097669010331 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1097669010332 amidase catalytic site [active] 1097669010333 Zn binding residues [ion binding]; other site 1097669010334 substrate binding site [chemical binding]; other site 1097669010335 LGFP repeat; Region: LGFP; pfam08310 1097669010336 PE family; Region: PE; pfam00934 1097669010337 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1097669010338 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1097669010339 active site 1097669010340 motif I; other site 1097669010341 motif II; other site 1097669010342 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1097669010343 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1097669010344 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1097669010345 putative acyl-acceptor binding pocket; other site 1097669010346 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1097669010347 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1097669010348 putative acyl-acceptor binding pocket; other site 1097669010349 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1097669010350 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1097669010351 putative acyl-acceptor binding pocket; other site 1097669010352 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 1097669010353 Phosphotransferase enzyme family; Region: APH; pfam01636 1097669010354 active site 1097669010355 ATP binding site [chemical binding]; other site 1097669010356 antibiotic binding site [chemical binding]; other site 1097669010357 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1097669010358 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1097669010359 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1097669010360 iron-sulfur cluster [ion binding]; other site 1097669010361 [2Fe-2S] cluster binding site [ion binding]; other site 1097669010362 Condensation domain; Region: Condensation; pfam00668 1097669010363 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 1097669010364 PE-PPE domain; Region: PE-PPE; pfam08237 1097669010365 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1097669010366 Condensation domain; Region: Condensation; pfam00668 1097669010367 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1097669010368 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1097669010369 active site 1097669010370 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1097669010371 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1097669010372 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1097669010373 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1097669010374 Enoylreductase; Region: PKS_ER; smart00829 1097669010375 NAD(P) binding site [chemical binding]; other site 1097669010376 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1097669010377 KR domain; Region: KR; pfam08659 1097669010378 putative NADP binding site [chemical binding]; other site 1097669010379 active site 1097669010380 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1097669010381 acyl-CoA synthetase; Validated; Region: PRK05850 1097669010382 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1097669010383 acyl-activating enzyme (AAE) consensus motif; other site 1097669010384 active site 1097669010385 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1097669010386 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1097669010387 Probable transposase; Region: OrfB_IS605; pfam01385 1097669010388 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 1097669010389 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 1097669010390 catalytic residues [active] 1097669010391 catalytic nucleophile [active] 1097669010392 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1097669010393 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1097669010394 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1097669010395 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1097669010396 Protein of unknown function (DUF2834); Region: DUF2834; pfam11196 1097669010397 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1097669010398 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1097669010399 Cupin domain; Region: Cupin_2; cl17218 1097669010400 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1097669010401 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1097669010402 seryl-tRNA synthetase; Provisional; Region: PRK05431 1097669010403 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1097669010404 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1097669010405 dimer interface [polypeptide binding]; other site 1097669010406 active site 1097669010407 motif 1; other site 1097669010408 motif 2; other site 1097669010409 motif 3; other site 1097669010410 Septum formation; Region: Septum_form; pfam13845 1097669010411 Septum formation; Region: Septum_form; pfam13845 1097669010412 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 1097669010413 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1097669010414 catalytic core [active] 1097669010415 prephenate dehydratase; Provisional; Region: PRK11898 1097669010416 Prephenate dehydratase; Region: PDT; pfam00800 1097669010417 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1097669010418 putative L-Phe binding site [chemical binding]; other site 1097669010419 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1097669010420 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1097669010421 Ferritin-like domain; Region: Ferritin; pfam00210 1097669010422 ferroxidase diiron center [ion binding]; other site 1097669010423 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582 1097669010424 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 1097669010425 putative active site [active] 1097669010426 catalytic site [active] 1097669010427 putative metal binding site [ion binding]; other site 1097669010428 Domain of unknown function (DUF4328); Region: DUF4328; pfam14219 1097669010429 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1097669010430 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1097669010431 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1097669010432 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1097669010433 Predicted membrane protein [Function unknown]; Region: COG2119 1097669010434 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 1097669010435 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 1097669010436 Fimbrial protein; Region: Fimbrial; cl01416 1097669010437 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 1097669010438 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1097669010439 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1097669010440 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1097669010441 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1097669010442 hypothetical protein; Provisional; Region: PRK07945 1097669010443 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 1097669010444 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 1097669010445 active site 1097669010446 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 1097669010447 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1097669010448 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1097669010449 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1097669010450 active site 1097669010451 dimer interface [polypeptide binding]; other site 1097669010452 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1097669010453 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1097669010454 active site 1097669010455 FMN binding site [chemical binding]; other site 1097669010456 substrate binding site [chemical binding]; other site 1097669010457 3Fe-4S cluster binding site [ion binding]; other site 1097669010458 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1097669010459 domain interface; other site 1097669010460 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1097669010461 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 1097669010462 EspG family; Region: ESX-1_EspG; pfam14011 1097669010463 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 1097669010464 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1097669010465 Walker A motif; other site 1097669010466 ATP binding site [chemical binding]; other site 1097669010467 Walker B motif; other site 1097669010468 arginine finger; other site 1097669010469 Protein of unknown function (DUF690); Region: DUF690; pfam05108 1097669010470 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1097669010471 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1097669010472 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1097669010473 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1097669010474 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1097669010475 PE family; Region: PE; pfam00934 1097669010476 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1097669010477 PPE family; Region: PPE; pfam00823 1097669010478 Proteins of 100 residues with WXG; Region: WXG100; cl02005 1097669010479 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1097669010480 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1097669010481 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 1097669010482 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 1097669010483 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 1097669010484 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1097669010485 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 1097669010486 active site 1097669010487 catalytic residues [active] 1097669010488 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 1097669010489 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1097669010490 Walker A motif; other site 1097669010491 ATP binding site [chemical binding]; other site 1097669010492 Walker B motif; other site 1097669010493 arginine finger; other site 1097669010494 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 1097669010495 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1097669010496 catalytic residues [active] 1097669010497 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1097669010498 active site 1097669010499 catalytic residues [active] 1097669010500 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 1097669010501 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1097669010502 EspG family; Region: ESX-1_EspG; pfam14011 1097669010503 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1097669010504 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1097669010505 PPE family; Region: PPE; pfam00823 1097669010506 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1097669010507 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1097669010508 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1097669010509 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1097669010510 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1097669010511 Protein of unknown function (DUF690); Region: DUF690; pfam05108 1097669010512 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1097669010513 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1097669010514 catalytic residue [active] 1097669010515 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 1097669010516 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1097669010517 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 1097669010518 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1097669010519 active site 1097669010520 NTP binding site [chemical binding]; other site 1097669010521 metal binding triad [ion binding]; metal-binding site 1097669010522 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1097669010523 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1097669010524 Zn2+ binding site [ion binding]; other site 1097669010525 Mg2+ binding site [ion binding]; other site 1097669010526 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1097669010527 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1097669010528 active site 1097669010529 Ap6A binding site [chemical binding]; other site 1097669010530 nudix motif; other site 1097669010531 metal binding site [ion binding]; metal-binding site 1097669010532 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 1097669010533 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1097669010534 RNA polymerase sigma factor SigM; Reviewed; Region: PRK09643 1097669010535 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1097669010536 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1097669010537 DNA binding residues [nucleotide binding] 1097669010538 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1097669010539 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1097669010540 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1097669010541 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1097669010542 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1097669010543 catalytic residues [active] 1097669010544 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1097669010545 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1097669010546 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1097669010547 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1097669010548 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1097669010549 active site 1097669010550 metal binding site [ion binding]; metal-binding site 1097669010551 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1097669010552 ParB-like nuclease domain; Region: ParB; smart00470 1097669010553 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1097669010554 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1097669010555 P-loop; other site 1097669010556 Magnesium ion binding site [ion binding]; other site 1097669010557 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1097669010558 Magnesium ion binding site [ion binding]; other site 1097669010559 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 1097669010560 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 1097669010561 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 1097669010562 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1097669010563 G-X-X-G motif; other site 1097669010564 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 1097669010565 RxxxH motif; other site 1097669010566 putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449 1097669010567 Uncharacterized conserved protein [Function unknown]; Region: COG0759 1097669010568 ribonuclease P; Reviewed; Region: rnpA; PRK00588 1097669010569 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399