-- dump date 20140619_155235 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1138877000001 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 1138877000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138877000003 Walker A motif; other site 1138877000004 ATP binding site [chemical binding]; other site 1138877000005 Walker B motif; other site 1138877000006 arginine finger; other site 1138877000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1138877000008 DnaA box-binding interface [nucleotide binding]; other site 1138877000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 1138877000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1138877000011 putative DNA binding surface [nucleotide binding]; other site 1138877000012 dimer interface [polypeptide binding]; other site 1138877000013 beta-clamp/clamp loader binding surface; other site 1138877000014 beta-clamp/translesion DNA polymerase binding surface; other site 1138877000015 recF protein; Region: recf; TIGR00611 1138877000016 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 1138877000017 Walker A/P-loop; other site 1138877000018 ATP binding site [chemical binding]; other site 1138877000019 Q-loop/lid; other site 1138877000020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1138877000021 ABC transporter signature motif; other site 1138877000022 Walker B; other site 1138877000023 D-loop; other site 1138877000024 H-loop/switch region; other site 1138877000025 hypothetical protein; Provisional; Region: PRK03195 1138877000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1138877000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1138877000028 Mg2+ binding site [ion binding]; other site 1138877000029 G-X-G motif; other site 1138877000030 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1138877000031 anchoring element; other site 1138877000032 dimer interface [polypeptide binding]; other site 1138877000033 ATP binding site [chemical binding]; other site 1138877000034 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1138877000035 active site 1138877000036 putative metal-binding site [ion binding]; other site 1138877000037 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1138877000038 DNA gyrase subunit A; Validated; Region: PRK05560 1138877000039 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1138877000040 CAP-like domain; other site 1138877000041 active site 1138877000042 primary dimer interface [polypeptide binding]; other site 1138877000043 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1138877000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1138877000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1138877000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1138877000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1138877000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1138877000049 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 1138877000050 Protein of unknown function (DUF2562); Region: DUF2562; pfam10814 1138877000051 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1138877000052 active site 1138877000053 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1138877000054 putative septation inhibitor protein; Reviewed; Region: PRK00159 1138877000055 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 1138877000056 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1138877000057 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1138877000058 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1138877000059 glutamine binding [chemical binding]; other site 1138877000060 catalytic triad [active] 1138877000061 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1138877000062 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1138877000063 active site 1138877000064 ATP binding site [chemical binding]; other site 1138877000065 substrate binding site [chemical binding]; other site 1138877000066 activation loop (A-loop); other site 1138877000067 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 1138877000068 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1138877000069 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1138877000070 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1138877000071 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1138877000072 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1138877000073 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1138877000074 active site 1138877000075 ATP binding site [chemical binding]; other site 1138877000076 substrate binding site [chemical binding]; other site 1138877000077 activation loop (A-loop); other site 1138877000078 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1138877000079 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1138877000080 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1138877000081 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1138877000082 active site 1138877000083 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1138877000084 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1138877000085 phosphopeptide binding site; other site 1138877000086 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 1138877000087 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1138877000088 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1138877000089 phosphopeptide binding site; other site 1138877000090 Nitronate monooxygenase; Region: NMO; pfam03060 1138877000091 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1138877000092 FMN binding site [chemical binding]; other site 1138877000093 substrate binding site [chemical binding]; other site 1138877000094 putative catalytic residue [active] 1138877000095 Transcription factor WhiB; Region: Whib; pfam02467 1138877000096 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1138877000097 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1138877000098 non-specific DNA binding site [nucleotide binding]; other site 1138877000099 salt bridge; other site 1138877000100 sequence-specific DNA binding site [nucleotide binding]; other site 1138877000101 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1138877000102 NlpC/P60 family; Region: NLPC_P60; pfam00877 1138877000103 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 1138877000104 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 1138877000105 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 1138877000106 Protein of unknown function (DUF2694); Region: DUF2694; pfam10904 1138877000107 Protein of unknown function (DUF2710); Region: DUF2710; pfam10921 1138877000108 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1138877000109 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 1138877000110 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 1138877000111 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1138877000112 catalytic residue [active] 1138877000113 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 1138877000114 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 1138877000115 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1138877000116 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1138877000117 acyl-activating enzyme (AAE) consensus motif; other site 1138877000118 active site 1138877000119 TIGR03084 family protein; Region: TIGR03084 1138877000120 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1138877000121 Wyosine base formation; Region: Wyosine_form; pfam08608 1138877000122 H+ Antiporter protein; Region: 2A0121; TIGR00900 1138877000123 hypothetical protein; Validated; Region: PRK00228 1138877000124 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 1138877000125 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1138877000126 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1138877000127 active site 1138877000128 HIGH motif; other site 1138877000129 nucleotide binding site [chemical binding]; other site 1138877000130 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1138877000131 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1138877000132 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1138877000133 active site 1138877000134 KMSKS motif; other site 1138877000135 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1138877000136 tRNA binding surface [nucleotide binding]; other site 1138877000137 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1138877000138 MarR family; Region: MarR; pfam01047 1138877000139 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1138877000140 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1138877000141 DNA-binding site [nucleotide binding]; DNA binding site 1138877000142 probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856 1138877000143 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1138877000144 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138877000145 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 1138877000146 inositol 1-phosphate synthase, Actinobacterial type; Region: mycothiol_INO1; TIGR03450 1138877000147 Predicted transcriptional regulators [Transcription]; Region: COG1695 1138877000148 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1138877000149 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1138877000150 Transglycosylase; Region: Transgly; pfam00912 1138877000151 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1138877000152 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1138877000153 Predicted integral membrane protein [Function unknown]; Region: COG5650 1138877000154 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 1138877000155 conserved cys residue [active] 1138877000156 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1138877000157 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1138877000158 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1138877000159 dimer interface [polypeptide binding]; other site 1138877000160 ssDNA binding site [nucleotide binding]; other site 1138877000161 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1138877000162 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1138877000163 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1138877000164 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1138877000165 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1138877000166 replicative DNA helicase; Validated; Region: PRK07773 1138877000167 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1138877000168 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1138877000169 Walker A motif; other site 1138877000170 ATP binding site [chemical binding]; other site 1138877000171 Walker B motif; other site 1138877000172 DNA binding loops [nucleotide binding] 1138877000173 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1138877000174 protein-splicing catalytic site; other site 1138877000175 thioester formation/cholesterol transfer; other site 1138877000176 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1138877000177 protein-splicing catalytic site; other site 1138877000178 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1138877000179 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 1138877000180 ADP-ribose binding site [chemical binding]; other site 1138877000181 Predicted phosphatase homologous to the C-terminal domain of histone macroH2A1 [General function prediction only]; Region: COG2110 1138877000182 Cellobiohydrolase A (1,4-beta-cellobiosidase A) [Carbohydrate transport and metabolism]; Region: CelA; COG5297 1138877000183 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 1138877000184 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1138877000185 FAD binding domain; Region: FAD_binding_4; pfam01565 1138877000186 Berberine and berberine like; Region: BBE; pfam08031 1138877000187 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 1138877000188 hypothetical protein; Validated; Region: PRK00068 1138877000189 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 1138877000190 homotetrameric interface [polypeptide binding]; other site 1138877000191 putative active site [active] 1138877000192 metal binding site [ion binding]; metal-binding site 1138877000193 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 1138877000194 Monomeric isocitrate dehydrogenase; Region: IDH; pfam03971 1138877000195 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138877000196 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138877000197 short chain dehydrogenase; Provisional; Region: PRK06197 1138877000198 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 1138877000199 putative NAD(P) binding site [chemical binding]; other site 1138877000200 active site 1138877000201 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1138877000202 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1138877000203 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1138877000204 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1138877000205 dimer interface [polypeptide binding]; other site 1138877000206 active site 1138877000207 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1138877000208 folate binding site [chemical binding]; other site 1138877000209 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 1138877000210 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1138877000211 putative NTP binding site [chemical binding]; other site 1138877000212 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1138877000213 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1138877000214 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1138877000215 Walker A/P-loop; other site 1138877000216 ATP binding site [chemical binding]; other site 1138877000217 Q-loop/lid; other site 1138877000218 ABC transporter signature motif; other site 1138877000219 Walker B; other site 1138877000220 D-loop; other site 1138877000221 H-loop/switch region; other site 1138877000222 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1138877000223 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1138877000224 ligand binding site [chemical binding]; other site 1138877000225 flexible hinge region; other site 1138877000226 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 1138877000227 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1138877000228 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 1138877000229 active site 1138877000230 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1138877000231 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1138877000232 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138877000233 homodimer interface [polypeptide binding]; other site 1138877000234 catalytic residue [active] 1138877000235 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138877000236 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138877000237 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138877000238 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 1138877000239 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1138877000240 dimerization interface [polypeptide binding]; other site 1138877000241 putative DNA binding site [nucleotide binding]; other site 1138877000242 putative Zn2+ binding site [ion binding]; other site 1138877000243 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 1138877000244 hydrogenase 4 subunit B; Validated; Region: PRK06521 1138877000245 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1138877000246 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1138877000247 NADH dehydrogenase; Region: NADHdh; cl00469 1138877000248 Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; COG4237 1138877000249 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1138877000250 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 1138877000251 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 1138877000252 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 1138877000253 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 1138877000254 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825 1138877000255 putative hydrophobic ligand binding site [chemical binding]; other site 1138877000256 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138877000257 S-adenosylmethionine binding site [chemical binding]; other site 1138877000258 Predicted membrane protein [Function unknown]; Region: COG3305 1138877000259 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1138877000260 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1138877000261 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1138877000262 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1138877000263 metal-binding site [ion binding] 1138877000264 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1138877000265 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1138877000266 Predicted integral membrane protein [Function unknown]; Region: COG5660 1138877000267 Putative zinc-finger; Region: zf-HC2; pfam13490 1138877000268 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1138877000269 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1138877000270 active site 1138877000271 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1138877000272 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138877000273 PPE family; Region: PPE; pfam00823 1138877000274 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1138877000275 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 1138877000276 FcoT-like thioesterase domain; Region: FcoT; pfam10862 1138877000277 acyl-CoA synthetase; Validated; Region: PRK05857 1138877000278 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138877000279 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 1138877000280 acyl-activating enzyme (AAE) consensus motif; other site 1138877000281 acyl-activating enzyme (AAE) consensus motif; other site 1138877000282 AMP binding site [chemical binding]; other site 1138877000283 active site 1138877000284 CoA binding site [chemical binding]; other site 1138877000285 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138877000286 AMP-binding enzyme; Region: AMP-binding; pfam00501 1138877000287 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138877000288 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138877000289 acyl-activating enzyme (AAE) consensus motif; other site 1138877000290 acyl-activating enzyme (AAE) consensus motif; other site 1138877000291 active site 1138877000292 AMP binding site [chemical binding]; other site 1138877000293 CoA binding site [chemical binding]; other site 1138877000294 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138877000295 Condensation domain; Region: Condensation; pfam00668 1138877000296 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1138877000297 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1138877000298 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1138877000299 acyl-activating enzyme (AAE) consensus motif; other site 1138877000300 AMP binding site [chemical binding]; other site 1138877000301 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138877000302 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 1138877000303 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 1138877000304 putative NAD(P) binding site [chemical binding]; other site 1138877000305 active site 1138877000306 putative substrate binding site [chemical binding]; other site 1138877000307 Predicted membrane protein [Function unknown]; Region: COG3336 1138877000308 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1138877000309 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1138877000310 metal-binding site [ion binding] 1138877000311 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1138877000312 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1138877000313 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1138877000314 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1138877000315 ligand binding site [chemical binding]; other site 1138877000316 flexible hinge region; other site 1138877000317 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1138877000318 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1138877000319 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1138877000320 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1138877000321 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1138877000322 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1138877000323 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1138877000324 motif II; other site 1138877000325 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1138877000326 PE family; Region: PE; pfam00934 1138877000327 Rhomboid family; Region: Rhomboid; pfam01694 1138877000328 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1138877000329 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1138877000330 active site 1138877000331 catalytic triad [active] 1138877000332 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1138877000333 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 1138877000334 NADP-binding site; other site 1138877000335 homotetramer interface [polypeptide binding]; other site 1138877000336 substrate binding site [chemical binding]; other site 1138877000337 homodimer interface [polypeptide binding]; other site 1138877000338 active site 1138877000339 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1138877000340 dimer interface [polypeptide binding]; other site 1138877000341 active site 1138877000342 histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656 1138877000343 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1138877000344 active site 1138877000345 motif I; other site 1138877000346 motif II; other site 1138877000347 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 1138877000348 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1138877000349 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 1138877000350 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1138877000351 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1138877000352 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1138877000353 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1138877000354 dimerization interface [polypeptide binding]; other site 1138877000355 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 1138877000356 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1138877000357 PYR/PP interface [polypeptide binding]; other site 1138877000358 dimer interface [polypeptide binding]; other site 1138877000359 TPP binding site [chemical binding]; other site 1138877000360 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1138877000361 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 1138877000362 TPP-binding site; other site 1138877000363 dimer interface [polypeptide binding]; other site 1138877000364 acyl-CoA synthetase; Validated; Region: PRK05852 1138877000365 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138877000366 Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; Region: FACL_fum10p_like; cd05926 1138877000367 acyl-activating enzyme (AAE) consensus motif; other site 1138877000368 acyl-activating enzyme (AAE) consensus motif; other site 1138877000369 putative AMP binding site [chemical binding]; other site 1138877000370 putative active site [active] 1138877000371 putative CoA binding site [chemical binding]; other site 1138877000372 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 1138877000373 elongation factor G; Reviewed; Region: PRK12740 1138877000374 G1 box; other site 1138877000375 putative GEF interaction site [polypeptide binding]; other site 1138877000376 GTP/Mg2+ binding site [chemical binding]; other site 1138877000377 Switch I region; other site 1138877000378 G2 box; other site 1138877000379 G3 box; other site 1138877000380 Switch II region; other site 1138877000381 G4 box; other site 1138877000382 G5 box; other site 1138877000383 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1138877000384 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1138877000385 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1138877000386 PPOX class probable F420-dependent enzyme, Rv0121 family; Region: Rv0121_F420; TIGR03668 1138877000387 PE family; Region: PE; pfam00934 1138877000388 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1138877000389 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1138877000390 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1138877000391 trehalose synthase; Region: treS_nterm; TIGR02456 1138877000392 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 1138877000393 active site 1138877000394 catalytic site [active] 1138877000395 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 1138877000396 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 1138877000397 Predicted membrane protein [Function unknown]; Region: COG3619 1138877000398 Predicted esterase [General function prediction only]; Region: COG0627 1138877000399 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 1138877000400 putative active site [active] 1138877000401 putative catalytic site [active] 1138877000402 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138877000403 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138877000404 active site 1138877000405 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 1138877000406 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1138877000407 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1138877000408 Coenzyme A binding pocket [chemical binding]; other site 1138877000409 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138877000410 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1138877000411 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138877000412 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138877000413 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138877000414 Cytochrome P450; Region: p450; cl12078 1138877000415 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1138877000416 SnoaL-like domain; Region: SnoaL_2; pfam12680 1138877000417 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 1138877000418 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138877000419 NAD(P) binding site [chemical binding]; other site 1138877000420 active site 1138877000421 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 1138877000422 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 1138877000423 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 1138877000424 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1138877000425 minor groove reading motif; other site 1138877000426 helix-hairpin-helix signature motif; other site 1138877000427 active site 1138877000428 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1138877000429 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 1138877000430 Cl- selectivity filter; other site 1138877000431 Cl- binding residues [ion binding]; other site 1138877000432 pore gating glutamate residue; other site 1138877000433 dimer interface [polypeptide binding]; other site 1138877000434 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138877000435 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138877000436 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138877000437 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1138877000438 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138877000439 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1138877000440 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 1138877000441 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 1138877000442 NAD(P) binding site [chemical binding]; other site 1138877000443 catalytic residues [active] 1138877000444 short chain dehydrogenase; Provisional; Region: PRK07791 1138877000445 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 1138877000446 NAD binding site [chemical binding]; other site 1138877000447 homodimer interface [polypeptide binding]; other site 1138877000448 active site 1138877000449 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1138877000450 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 1138877000451 NAD(P) binding site [chemical binding]; other site 1138877000452 PE family; Region: PE; pfam00934 1138877000453 PE-PPE domain; Region: PE-PPE; pfam08237 1138877000454 PE-PPE domain; Region: PE-PPE; pfam08237 1138877000455 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 1138877000456 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 1138877000457 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 1138877000458 Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155 1138877000459 FAD binding site [chemical binding]; other site 1138877000460 substrate binding site [chemical binding]; other site 1138877000461 catalytic base [active] 1138877000462 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 1138877000463 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 1138877000464 ligand binding site [chemical binding]; other site 1138877000465 homodimer interface [polypeptide binding]; other site 1138877000466 NAD(P) binding site [chemical binding]; other site 1138877000467 trimer interface B [polypeptide binding]; other site 1138877000468 trimer interface A [polypeptide binding]; other site 1138877000469 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 1138877000470 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 1138877000471 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 1138877000472 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 1138877000473 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138877000474 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138877000475 QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360 1138877000476 PE family; Region: PE; pfam00934 1138877000477 PE-PPE domain; Region: PE-PPE; pfam08237 1138877000478 PE family; Region: PE; pfam00934 1138877000479 PE-PPE domain; Region: PE-PPE; pfam08237 1138877000480 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1138877000481 FAD binding domain; Region: FAD_binding_4; pfam01565 1138877000482 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 1138877000483 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1138877000484 NAD(P) binding site [chemical binding]; other site 1138877000485 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1138877000486 active site 1138877000487 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1138877000488 putative hydrophobic ligand binding site [chemical binding]; other site 1138877000489 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1138877000490 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1138877000491 DNA-binding site [nucleotide binding]; DNA binding site 1138877000492 FCD domain; Region: FCD; cl11656 1138877000493 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07786 1138877000494 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138877000495 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1138877000496 acyl-activating enzyme (AAE) consensus motif; other site 1138877000497 acyl-activating enzyme (AAE) consensus motif; other site 1138877000498 putative AMP binding site [chemical binding]; other site 1138877000499 putative active site [active] 1138877000500 putative CoA binding site [chemical binding]; other site 1138877000501 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1138877000502 Permease; Region: Permease; pfam02405 1138877000503 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1138877000504 Permease; Region: Permease; pfam02405 1138877000505 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138877000506 mce related protein; Region: MCE; pfam02470 1138877000507 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1138877000508 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138877000509 mce related protein; Region: MCE; pfam02470 1138877000510 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1138877000511 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138877000512 mce related protein; Region: MCE; pfam02470 1138877000513 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138877000514 mce related protein; Region: MCE; pfam02470 1138877000515 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138877000516 mce related protein; Region: MCE; pfam02470 1138877000517 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138877000518 mce related protein; Region: MCE; pfam02470 1138877000519 RDD family; Region: RDD; pfam06271 1138877000520 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 1138877000521 Predicted membrane protein [Function unknown]; Region: COG1511 1138877000522 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1138877000523 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1138877000524 Pirin-related protein [General function prediction only]; Region: COG1741 1138877000525 Pirin; Region: Pirin; pfam02678 1138877000526 RNA polymerase factor sigma-70; Validated; Region: PRK08241 1138877000527 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1138877000528 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1138877000529 DNA binding residues [nucleotide binding] 1138877000530 SnoaL-like domain; Region: SnoaL_2; pfam12680 1138877000531 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1138877000532 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1138877000533 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 1138877000534 putative metallohydrolase, TIGR04338 family; Region: HEXXH_Rv0185 1138877000535 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1138877000536 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1138877000537 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1138877000538 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1138877000539 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1138877000540 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138877000541 S-adenosylmethionine binding site [chemical binding]; other site 1138877000542 SPW repeat; Region: SPW; pfam03779 1138877000543 SPW repeat; Region: SPW; pfam03779 1138877000544 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 1138877000545 6-phosphogluconate dehydratase; Region: edd; TIGR01196 1138877000546 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 1138877000547 putative homodimer interface [polypeptide binding]; other site 1138877000548 putative homotetramer interface [polypeptide binding]; other site 1138877000549 putative allosteric switch controlling residues; other site 1138877000550 putative metal binding site [ion binding]; other site 1138877000551 putative homodimer-homodimer interface [polypeptide binding]; other site 1138877000552 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1138877000553 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138877000554 putative substrate translocation pore; other site 1138877000555 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1138877000556 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 1138877000557 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1138877000558 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1138877000559 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1138877000560 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1138877000561 Walker A/P-loop; other site 1138877000562 ATP binding site [chemical binding]; other site 1138877000563 Q-loop/lid; other site 1138877000564 ABC transporter signature motif; other site 1138877000565 Walker B; other site 1138877000566 D-loop; other site 1138877000567 H-loop/switch region; other site 1138877000568 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1138877000569 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1138877000570 Walker A/P-loop; other site 1138877000571 ATP binding site [chemical binding]; other site 1138877000572 Q-loop/lid; other site 1138877000573 ABC transporter signature motif; other site 1138877000574 Walker B; other site 1138877000575 D-loop; other site 1138877000576 H-loop/switch region; other site 1138877000577 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1138877000578 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1138877000579 dimerization interface [polypeptide binding]; other site 1138877000580 DNA binding residues [nucleotide binding] 1138877000581 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138877000582 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138877000583 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1138877000584 The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762 1138877000585 putative [Fe4-S4] binding site [ion binding]; other site 1138877000586 putative molybdopterin cofactor binding site [chemical binding]; other site 1138877000587 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1138877000588 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 1138877000589 putative molybdopterin cofactor binding site; other site 1138877000590 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 1138877000591 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 1138877000592 active site 1138877000593 Zn binding site [ion binding]; other site 1138877000594 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1138877000595 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 1138877000596 Predicted integral membrane protein [Function unknown]; Region: COG0392 1138877000597 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1138877000598 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1138877000599 MMPL family; Region: MMPL; pfam03176 1138877000600 MMPL family; Region: MMPL; pfam03176 1138877000601 LabA_like proteins; Region: LabA_like; cd06167 1138877000602 putative metal binding site [ion binding]; other site 1138877000603 Putative methyltransferase; Region: Methyltransf_4; pfam02390 1138877000604 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 1138877000605 active site 1138877000606 substrate-binding site [chemical binding]; other site 1138877000607 metal-binding site [ion binding] 1138877000608 GTP binding site [chemical binding]; other site 1138877000609 nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526 1138877000610 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 1138877000611 active site 1138877000612 (T/H)XGH motif; other site 1138877000613 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 1138877000614 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 1138877000615 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 1138877000616 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1138877000617 FeS/SAM binding site; other site 1138877000618 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 1138877000619 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138877000620 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1138877000621 acyl-activating enzyme (AAE) consensus motif; other site 1138877000622 acyl-activating enzyme (AAE) consensus motif; other site 1138877000623 putative AMP binding site [chemical binding]; other site 1138877000624 putative active site [active] 1138877000625 putative CoA binding site [chemical binding]; other site 1138877000626 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138877000627 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138877000628 active site 1138877000629 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 1138877000630 putative active site [active] 1138877000631 putative catalytic site [active] 1138877000632 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1138877000633 active site 2 [active] 1138877000634 active site 1 [active] 1138877000635 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1138877000636 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1138877000637 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1138877000638 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cd00321 1138877000639 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1138877000640 Moco binding site; other site 1138877000641 metal coordination site [ion binding]; other site 1138877000642 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1138877000643 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1138877000644 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1138877000645 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1138877000646 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 1138877000647 enoyl-CoA hydratase; Provisional; Region: PRK08252 1138877000648 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138877000649 substrate binding site [chemical binding]; other site 1138877000650 oxyanion hole (OAH) forming residues; other site 1138877000651 trimer interface [polypeptide binding]; other site 1138877000652 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 1138877000653 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1138877000654 NAD binding site [chemical binding]; other site 1138877000655 catalytic residues [active] 1138877000656 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138877000657 S-adenosylmethionine binding site [chemical binding]; other site 1138877000658 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1138877000659 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1138877000660 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 1138877000661 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1138877000662 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 1138877000663 putative active site [active] 1138877000664 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 1138877000665 active site 1138877000666 substrate binding pocket [chemical binding]; other site 1138877000667 homodimer interaction site [polypeptide binding]; other site 1138877000668 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138877000669 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1138877000670 active site 1138877000671 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138877000672 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138877000673 Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain; Region: RNRR2_Rv0233_like; cd07911 1138877000674 active site 1138877000675 diiron metal binding site [ion binding]; other site 1138877000676 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1138877000677 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1138877000678 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1138877000679 NAD(P) binding site [chemical binding]; other site 1138877000680 catalytic residues [active] 1138877000681 Lipase maturation factor; Region: LMF1; pfam06762 1138877000682 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 1138877000683 Protein of unknown function (DUF2613); Region: DUF2613; pfam11021 1138877000684 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1138877000685 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1138877000686 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138877000687 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138877000688 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 1138877000689 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1138877000690 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 1138877000691 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138877000692 NAD(P) binding site [chemical binding]; other site 1138877000693 active site 1138877000694 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 1138877000695 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1138877000696 dimer interface [polypeptide binding]; other site 1138877000697 active site 1138877000698 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1138877000699 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1138877000700 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 1138877000701 FAD binding site [chemical binding]; other site 1138877000702 substrate binding site [chemical binding]; other site 1138877000703 catalytic residues [active] 1138877000704 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1138877000705 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1138877000706 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386 1138877000707 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1138877000708 catalytic loop [active] 1138877000709 iron binding site [ion binding]; other site 1138877000710 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803 1138877000711 L-aspartate oxidase; Provisional; Region: PRK06175 1138877000712 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1138877000713 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1138877000714 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1138877000715 putative dimer interface [polypeptide binding]; other site 1138877000716 nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374 1138877000717 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1138877000718 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1138877000719 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1138877000720 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 1138877000721 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 1138877000722 homotrimer interface [polypeptide binding]; other site 1138877000723 Walker A motif; other site 1138877000724 GTP binding site [chemical binding]; other site 1138877000725 Walker B motif; other site 1138877000726 cobyric acid synthase; Provisional; Region: PRK00784 1138877000727 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 1138877000728 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1138877000729 catalytic triad [active] 1138877000730 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138877000731 PPE family; Region: PPE; pfam00823 1138877000732 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1138877000733 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1138877000734 putative active site [active] 1138877000735 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 1138877000736 putative active site [active] 1138877000737 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 1138877000738 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1138877000739 active site 1138877000740 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 1138877000741 DNA binding site [nucleotide binding] 1138877000742 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1138877000743 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1138877000744 Coenzyme A binding pocket [chemical binding]; other site 1138877000745 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 1138877000746 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 1138877000747 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 1138877000748 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1138877000749 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1138877000750 intersubunit interface [polypeptide binding]; other site 1138877000751 5-oxoprolinase; Region: PLN02666 1138877000752 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 1138877000753 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 1138877000754 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 1138877000755 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1138877000756 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 1138877000757 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 1138877000758 nucleotide binding site [chemical binding]; other site 1138877000759 acyl-CoA synthetase; Validated; Region: PRK07788 1138877000760 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138877000761 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138877000762 active site 1138877000763 CoA binding site [chemical binding]; other site 1138877000764 AMP binding site [chemical binding]; other site 1138877000765 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138877000766 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138877000767 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 1138877000768 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138877000769 FAD binding site [chemical binding]; other site 1138877000770 substrate binding site [chemical binding]; other site 1138877000771 catalytic base [active] 1138877000772 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1138877000773 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138877000774 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138877000775 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1138877000776 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1138877000777 Zn binding site [ion binding]; other site 1138877000778 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 1138877000779 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 1138877000780 putative active site [active] 1138877000781 PE family; Region: PE; pfam00934 1138877000782 PE family; Region: PE; pfam00934 1138877000783 PE family; Region: PE; pfam00934 1138877000784 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138877000785 PPE family; Region: PPE; pfam00823 1138877000786 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138877000787 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138877000788 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1138877000789 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 1138877000790 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138877000791 Walker A motif; other site 1138877000792 ATP binding site [chemical binding]; other site 1138877000793 Walker B motif; other site 1138877000794 arginine finger; other site 1138877000795 Protein of unknown function (DUF690); Region: DUF690; pfam05108 1138877000796 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1138877000797 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1138877000798 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1138877000799 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1138877000800 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1138877000801 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138877000802 PPE family; Region: PPE; pfam00823 1138877000803 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1138877000804 EspG family; Region: ESX-1_EspG; pfam14011 1138877000805 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 1138877000806 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1138877000807 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 1138877000808 active site 1138877000809 catalytic residues [active] 1138877000810 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 1138877000811 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1138877000812 Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752 1138877000813 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 1138877000814 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138877000815 S-adenosylmethionine binding site [chemical binding]; other site 1138877000816 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4424 1138877000817 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1138877000818 Sulfatase; Region: Sulfatase; cl17466 1138877000819 PE family; Region: PE; pfam00934 1138877000820 hypothetical protein; Region: PHA01748 1138877000821 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 1138877000822 putative active site [active] 1138877000823 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138877000824 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138877000825 light-dependent protochlorophyllide reductase (LPOR)-like, classical (c)-like SDRs; Region: LPOR_like_SDR_c_like; cd09810 1138877000826 protochlorophyllide reductase; Region: PLN00015 1138877000827 putative NAD(P) binding site [chemical binding]; other site 1138877000828 active site 1138877000829 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138877000830 PPE family; Region: PPE; pfam00823 1138877000831 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138877000832 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1138877000833 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138877000834 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1138877000835 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1138877000836 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138877000837 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1138877000838 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138877000839 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1138877000840 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1138877000841 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1138877000842 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 1138877000843 putative FMN binding site [chemical binding]; other site 1138877000844 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1138877000845 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1138877000846 active site 1138877000847 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 1138877000848 SnoaL-like domain; Region: SnoaL_4; pfam13577 1138877000849 SnoaL-like domain; Region: SnoaL_3; pfam13474 1138877000850 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 1138877000851 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1138877000852 nucleotide binding site [chemical binding]; other site 1138877000853 Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones]; Region: HtpG; COG0326 1138877000854 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 1138877000855 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 1138877000856 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 1138877000857 active site 1138877000858 catalytic residues [active] 1138877000859 Muconolactone delta-isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CatC1; COG4829 1138877000860 Muconolactone delta-isomerase; Region: MIase; cl01992 1138877000861 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 1138877000862 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 1138877000863 putative active site [active] 1138877000864 catalytic site [active] 1138877000865 putative metal binding site [ion binding]; other site 1138877000866 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 1138877000867 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 1138877000868 putative substrate binding pocket [chemical binding]; other site 1138877000869 AC domain interface; other site 1138877000870 catalytic triad [active] 1138877000871 AB domain interface; other site 1138877000872 interchain disulfide; other site 1138877000873 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1138877000874 trimer interface [polypeptide binding]; other site 1138877000875 active site 1138877000876 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1138877000877 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1138877000878 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1138877000879 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1138877000880 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 1138877000881 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1138877000882 dimerization interface [polypeptide binding]; other site 1138877000883 putative DNA binding site [nucleotide binding]; other site 1138877000884 putative Zn2+ binding site [ion binding]; other site 1138877000885 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1138877000886 active site residue [active] 1138877000887 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138877000888 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138877000889 Cytochrome P450; Region: p450; cl12078 1138877000890 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 1138877000891 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138877000892 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1138877000893 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1138877000894 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138877000895 S-adenosylmethionine binding site [chemical binding]; other site 1138877000896 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138877000897 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138877000898 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1138877000899 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1138877000900 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1138877000901 SnoaL-like domain; Region: SnoaL_2; pfam12680 1138877000902 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1138877000903 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1138877000904 substrate binding site; other site 1138877000905 tetramer interface; other site 1138877000906 PE family; Region: PE; pfam00934 1138877000907 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1138877000908 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1138877000909 active site 1138877000910 aminotransferase AlaT; Validated; Region: PRK09265 1138877000911 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1138877000912 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138877000913 homodimer interface [polypeptide binding]; other site 1138877000914 catalytic residue [active] 1138877000915 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1138877000916 4Fe-4S binding domain; Region: Fer4; pfam00037 1138877000917 Cysteine-rich domain; Region: CCG; pfam02754 1138877000918 Cysteine-rich domain; Region: CCG; pfam02754 1138877000919 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1138877000920 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1138877000921 DNA binding residues [nucleotide binding] 1138877000922 dimerization interface [polypeptide binding]; other site 1138877000923 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 1138877000924 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1138877000925 G1 box; other site 1138877000926 GTP/Mg2+ binding site [chemical binding]; other site 1138877000927 G2 box; other site 1138877000928 Switch I region; other site 1138877000929 G3 box; other site 1138877000930 Switch II region; other site 1138877000931 G4 box; other site 1138877000932 G5 box; other site 1138877000933 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 1138877000934 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1138877000935 G1 box; other site 1138877000936 GTP/Mg2+ binding site [chemical binding]; other site 1138877000937 G2 box; other site 1138877000938 Switch I region; other site 1138877000939 G3 box; other site 1138877000940 Switch II region; other site 1138877000941 Uncharacterized MobA-related protein [General function prediction only]; Region: COG2068 1138877000942 active site 1138877000943 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1138877000944 TIGR04255 family protein; Region: sporadTIGR04255 1138877000945 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1138877000946 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1138877000947 nucleotide binding site [chemical binding]; other site 1138877000948 NEF interaction site [polypeptide binding]; other site 1138877000949 SBD interface [polypeptide binding]; other site 1138877000950 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 1138877000951 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1138877000952 dimer interface [polypeptide binding]; other site 1138877000953 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1138877000954 chaperone protein DnaJ; Provisional; Region: PRK14279 1138877000955 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1138877000956 HSP70 interaction site [polypeptide binding]; other site 1138877000957 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1138877000958 Zn binding sites [ion binding]; other site 1138877000959 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1138877000960 dimer interface [polypeptide binding]; other site 1138877000961 Helix-Turn-Helix DNA binding domain of HspR-like transcription regulators; Region: HTH_HspR-like; cd01279 1138877000962 DNA binding residues [nucleotide binding] 1138877000963 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1138877000964 putative dimer interface [polypeptide binding]; other site 1138877000965 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138877000966 PPE family; Region: PPE; pfam00823 1138877000967 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1138877000968 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138877000969 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138877000970 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138877000971 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1138877000972 CoenzymeA binding site [chemical binding]; other site 1138877000973 subunit interaction site [polypeptide binding]; other site 1138877000974 PHB binding site; other site 1138877000975 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1138877000976 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1138877000977 GDP-binding site [chemical binding]; other site 1138877000978 ACT binding site; other site 1138877000979 IMP binding site; other site 1138877000980 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 1138877000981 Peptidase family M50; Region: Peptidase_M50; pfam02163 1138877000982 active site 1138877000983 putative substrate binding region [chemical binding]; other site 1138877000984 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 1138877000985 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1138877000986 MgtE intracellular N domain; Region: MgtE_N; pfam03448 1138877000987 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1138877000988 Divalent cation transporter; Region: MgtE; pfam01769 1138877000989 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1138877000990 fructose-bisphosphate aldolase, class II, yeast/E. coli subtype; Region: FruBisAldo_II_A; TIGR01520 1138877000991 active site 1138877000992 intersubunit interface [polypeptide binding]; other site 1138877000993 zinc binding site [ion binding]; other site 1138877000994 Na+ binding site [ion binding]; other site 1138877000995 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1138877000996 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1138877000997 Predicted glycosyl hydrolase [Carbohydrate transport and metabolism]; Region: COG4833 1138877000998 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 1138877000999 AAA domain; Region: AAA_33; pfam13671 1138877001000 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 1138877001001 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 1138877001002 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 1138877001003 putative hydrophobic ligand binding site [chemical binding]; other site 1138877001004 MoxR-like ATPases [General function prediction only]; Region: COG0714 1138877001005 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 1138877001006 Ligand binding site; other site 1138877001007 metal-binding site 1138877001008 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 1138877001009 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1138877001010 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1138877001011 carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416 1138877001012 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 1138877001013 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1138877001014 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1138877001015 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1138877001016 catalytic loop [active] 1138877001017 iron binding site [ion binding]; other site 1138877001018 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1138877001019 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 1138877001020 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 1138877001021 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1138877001022 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 1138877001023 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1138877001024 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1138877001025 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1138877001026 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1138877001027 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1138877001028 dimerization interface [polypeptide binding]; other site 1138877001029 Uncharacterized conserved protein [Function unknown]; Region: COG3360 1138877001030 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1138877001031 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1138877001032 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1138877001033 active site 1138877001034 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1138877001035 Clp amino terminal domain; Region: Clp_N; pfam02861 1138877001036 Clp amino terminal domain; Region: Clp_N; pfam02861 1138877001037 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138877001038 Walker A motif; other site 1138877001039 ATP binding site [chemical binding]; other site 1138877001040 Walker B motif; other site 1138877001041 arginine finger; other site 1138877001042 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138877001043 Walker A motif; other site 1138877001044 ATP binding site [chemical binding]; other site 1138877001045 Walker B motif; other site 1138877001046 arginine finger; other site 1138877001047 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1138877001048 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1138877001049 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1138877001050 heme-binding site [chemical binding]; other site 1138877001051 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 1138877001052 FAD binding pocket [chemical binding]; other site 1138877001053 FAD binding motif [chemical binding]; other site 1138877001054 phosphate binding motif [ion binding]; other site 1138877001055 beta-alpha-beta structure motif; other site 1138877001056 NAD binding pocket [chemical binding]; other site 1138877001057 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1138877001058 cyclase homology domain; Region: CHD; cd07302 1138877001059 nucleotidyl binding site; other site 1138877001060 metal binding site [ion binding]; metal-binding site 1138877001061 dimer interface [polypeptide binding]; other site 1138877001062 Predicted ATPase [General function prediction only]; Region: COG3903 1138877001063 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1138877001064 Walker A motif; other site 1138877001065 ATP binding site [chemical binding]; other site 1138877001066 Walker B motif; other site 1138877001067 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1138877001068 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1138877001069 DNA binding residues [nucleotide binding] 1138877001070 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138877001071 PPE family; Region: PPE; pfam00823 1138877001072 Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase) [Nucleotide transport and metabolism]; Region: PurT; COG0027 1138877001073 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1138877001074 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 1138877001075 active site residue [active] 1138877001076 O-succinylhomoserine sulfhydrylase; Provisional; Region: PRK07810 1138877001077 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1138877001078 homodimer interface [polypeptide binding]; other site 1138877001079 substrate-cofactor binding pocket; other site 1138877001080 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138877001081 catalytic residue [active] 1138877001082 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1138877001083 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1138877001084 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1138877001085 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1138877001086 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1138877001087 active site 1138877001088 PLD-like domain; Region: PLDc_2; pfam13091 1138877001089 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1138877001090 Beta-lactamase; Region: Beta-lactamase; pfam00144 1138877001091 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 1138877001092 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138877001093 FAD binding site [chemical binding]; other site 1138877001094 substrate binding pocket [chemical binding]; other site 1138877001095 catalytic base [active] 1138877001096 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 1138877001097 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1138877001098 putative transposase OrfB; Reviewed; Region: PHA02517 1138877001099 HTH-like domain; Region: HTH_21; pfam13276 1138877001100 Integrase core domain; Region: rve; pfam00665 1138877001101 Integrase core domain; Region: rve_3; pfam13683 1138877001102 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1138877001103 Transposase; Region: HTH_Tnp_1; cl17663 1138877001104 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1138877001105 acyl-CoA synthetase; Validated; Region: PRK05850 1138877001106 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1138877001107 acyl-activating enzyme (AAE) consensus motif; other site 1138877001108 active site 1138877001109 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 1138877001110 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1138877001111 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1138877001112 active site 1138877001113 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1138877001114 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1138877001115 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1138877001116 Thioesterase; Region: PKS_TE; smart00824 1138877001117 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1138877001118 glucose-6-phosphate dehydrogenase (coenzyme-F420); Region: F420_G6P_DH; TIGR03554 1138877001119 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 1138877001120 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1138877001121 phosphate acetyltransferase; Reviewed; Region: PRK05632 1138877001122 DRTGG domain; Region: DRTGG; pfam07085 1138877001123 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1138877001124 propionate/acetate kinase; Provisional; Region: PRK12379 1138877001125 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1138877001126 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1138877001127 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1138877001128 active site 1138877001129 ATP binding site [chemical binding]; other site 1138877001130 substrate binding site [chemical binding]; other site 1138877001131 activation loop (A-loop); other site 1138877001132 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1138877001133 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1138877001134 substrate binding pocket [chemical binding]; other site 1138877001135 membrane-bound complex binding site; other site 1138877001136 hinge residues; other site 1138877001137 NUDIX domain; Region: NUDIX; pfam00293 1138877001138 nudix motif; other site 1138877001139 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1138877001140 thiamine phosphate binding site [chemical binding]; other site 1138877001141 active site 1138877001142 pyrophosphate binding site [ion binding]; other site 1138877001143 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1138877001144 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1138877001145 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1138877001146 thiS-thiF/thiG interaction site; other site 1138877001147 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1138877001148 ThiS interaction site; other site 1138877001149 putative active site [active] 1138877001150 tetramer interface [polypeptide binding]; other site 1138877001151 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 1138877001152 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1138877001153 PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH. Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816 1138877001154 PA/protease or protease-like domain interface [polypeptide binding]; other site 1138877001155 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 1138877001156 active site 1138877001157 metal binding site [ion binding]; metal-binding site 1138877001158 Predicted metalloprotease [General function prediction only]; Region: COG2321 1138877001159 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1138877001160 Zn binding site [ion binding]; other site 1138877001161 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1138877001162 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1138877001163 dimer interface [polypeptide binding]; other site 1138877001164 substrate binding site [chemical binding]; other site 1138877001165 ATP binding site [chemical binding]; other site 1138877001166 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1138877001167 ThiC-associated domain; Region: ThiC-associated; pfam13667 1138877001168 ThiC family; Region: ThiC; pfam01964 1138877001169 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1138877001170 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 1138877001171 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1138877001172 motif II; other site 1138877001173 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1138877001174 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1138877001175 putative catalytic site [active] 1138877001176 putative phosphate binding site [ion binding]; other site 1138877001177 active site 1138877001178 metal binding site A [ion binding]; metal-binding site 1138877001179 DNA binding site [nucleotide binding] 1138877001180 putative AP binding site [nucleotide binding]; other site 1138877001181 putative metal binding site B [ion binding]; other site 1138877001182 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1138877001183 active site 1138877001184 catalytic residues [active] 1138877001185 metal binding site [ion binding]; metal-binding site 1138877001186 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 1138877001187 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1138877001188 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 1138877001189 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1138877001190 E-class dimer interface [polypeptide binding]; other site 1138877001191 P-class dimer interface [polypeptide binding]; other site 1138877001192 active site 1138877001193 Cu2+ binding site [ion binding]; other site 1138877001194 Zn2+ binding site [ion binding]; other site 1138877001195 carboxylate-amine ligase; Provisional; Region: PRK13517 1138877001196 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 1138877001197 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 1138877001198 AAA family ATPase, CDC48 subfamily; Region: CDC48; TIGR01243 1138877001199 Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359 1138877001200 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138877001201 Walker A motif; other site 1138877001202 ATP binding site [chemical binding]; other site 1138877001203 Walker B motif; other site 1138877001204 arginine finger; other site 1138877001205 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138877001206 Walker A motif; other site 1138877001207 ATP binding site [chemical binding]; other site 1138877001208 Walker B motif; other site 1138877001209 arginine finger; other site 1138877001210 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 1138877001211 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1138877001212 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 1138877001213 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1138877001214 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1138877001215 dimer interface [polypeptide binding]; other site 1138877001216 putative functional site; other site 1138877001217 putative MPT binding site; other site 1138877001218 short chain dehydrogenase; Provisional; Region: PRK06197 1138877001219 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 1138877001220 putative NAD(P) binding site [chemical binding]; other site 1138877001221 active site 1138877001222 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1138877001223 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1138877001224 ring oligomerisation interface [polypeptide binding]; other site 1138877001225 ATP/Mg binding site [chemical binding]; other site 1138877001226 stacking interactions; other site 1138877001227 hinge regions; other site 1138877001228 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138877001229 PPE family; Region: PPE; pfam00823 1138877001230 Protein of unknown function (DUF664); Region: DUF664; pfam04978 1138877001231 DinB superfamily; Region: DinB_2; pfam12867 1138877001232 putative anti-sigmaE protein; Provisional; Region: PRK13920 1138877001233 Anti-sigma-K factor rskA; Region: RskA; pfam10099 1138877001234 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 1138877001235 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1138877001236 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1138877001237 DNA binding residues [nucleotide binding] 1138877001238 Steroid 5-alpha reductase family enzyme [General function prediction only]; Region: COG3752 1138877001239 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1138877001240 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138877001241 S-adenosylmethionine binding site [chemical binding]; other site 1138877001242 Uncharacterized conserved protein [Function unknown]; Region: COG3496 1138877001243 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 1138877001244 Subunit A of Class III extradiol dioxygenases; Region: Extradiol_Dioxygenase_3A_like; cl06673 1138877001245 dimer interface [polypeptide binding]; other site 1138877001246 Transport protein; Region: actII; TIGR00833 1138877001247 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1138877001248 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138877001249 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138877001250 PPE family; Region: PPE; pfam00823 1138877001251 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138877001252 Protein of unknown function (DUF2782); Region: DUF2782; pfam11191 1138877001253 enoyl-CoA hydratase; Provisional; Region: PRK12478 1138877001254 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138877001255 substrate binding site [chemical binding]; other site 1138877001256 oxyanion hole (OAH) forming residues; other site 1138877001257 trimer interface [polypeptide binding]; other site 1138877001258 PemK-like protein; Region: PemK; pfam02452 1138877001259 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 1138877001260 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1138877001261 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 1138877001262 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1138877001263 NAD(P) binding site [chemical binding]; other site 1138877001264 catalytic residues [active] 1138877001265 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3564 1138877001266 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 1138877001267 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1138877001268 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1138877001269 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1138877001270 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1138877001271 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1138877001272 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1138877001273 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1138877001274 non-specific DNA binding site [nucleotide binding]; other site 1138877001275 salt bridge; other site 1138877001276 sequence-specific DNA binding site [nucleotide binding]; other site 1138877001277 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 1138877001278 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1138877001279 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 1138877001280 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 1138877001281 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1138877001282 active site 1138877001283 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1138877001284 active site 2 [active] 1138877001285 isocitrate lyase; Provisional; Region: PRK15063 1138877001286 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cd06556 1138877001287 oligomerization interface [polypeptide binding]; other site 1138877001288 active site 1138877001289 metal binding site [ion binding]; metal-binding site 1138877001290 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 1138877001291 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1138877001292 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1138877001293 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1138877001294 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138877001295 S-adenosylmethionine binding site [chemical binding]; other site 1138877001296 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1138877001297 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1138877001298 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138877001299 S-adenosylmethionine binding site [chemical binding]; other site 1138877001300 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224 1138877001301 UbiA prenyltransferase family; Region: UbiA; pfam01040 1138877001302 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138877001303 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138877001304 Predicted membrane protein [Function unknown]; Region: COG2733 1138877001305 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1138877001306 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1138877001307 non-specific DNA binding site [nucleotide binding]; other site 1138877001308 salt bridge; other site 1138877001309 sequence-specific DNA binding site [nucleotide binding]; other site 1138877001310 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 1138877001311 Protein of unknown function (DUF2599); Region: DUF2599; pfam10783 1138877001312 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1138877001313 intersubunit interface [polypeptide binding]; other site 1138877001314 active site 1138877001315 catalytic residue [active] 1138877001316 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1138877001317 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1138877001318 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 1138877001319 putative active site [active] 1138877001320 catalytic triad [active] 1138877001321 putative dimer interface [polypeptide binding]; other site 1138877001322 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 1138877001323 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 1138877001324 FAD binding domain; Region: FAD_binding_4; pfam01565 1138877001325 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1138877001326 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 1138877001327 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1138877001328 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 1138877001329 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1138877001330 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1138877001331 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138877001332 NAD(P) binding site [chemical binding]; other site 1138877001333 active site 1138877001334 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1138877001335 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1138877001336 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 1138877001337 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 1138877001338 putative ADP-binding pocket [chemical binding]; other site 1138877001339 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1138877001340 L-lysine exporter; Region: 2a75; TIGR00948 1138877001341 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1138877001342 catalytic core [active] 1138877001343 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 1138877001344 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1138877001345 dimer interface [polypeptide binding]; other site 1138877001346 phosphorylation site [posttranslational modification] 1138877001347 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1138877001348 ATP binding site [chemical binding]; other site 1138877001349 Mg2+ binding site [ion binding]; other site 1138877001350 G-X-G motif; other site 1138877001351 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1138877001352 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1138877001353 active site 1138877001354 phosphorylation site [posttranslational modification] 1138877001355 intermolecular recognition site; other site 1138877001356 dimerization interface [polypeptide binding]; other site 1138877001357 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1138877001358 DNA binding site [nucleotide binding] 1138877001359 GMC oxidoreductase; Region: GMC_oxred_N; pfam00732 1138877001360 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1138877001361 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1138877001362 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1138877001363 DNA-binding site [nucleotide binding]; DNA binding site 1138877001364 FCD domain; Region: FCD; pfam07729 1138877001365 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1138877001366 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1138877001367 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1138877001368 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1138877001369 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1138877001370 Diacylglycerol kinase catalytic domain (presumed); Region: DAGKc; smart00046 1138877001371 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1138877001372 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 1138877001373 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1138877001374 DNA binding domain, excisionase family; Region: excise; TIGR01764 1138877001375 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1138877001376 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 1138877001377 putative NAD(P) binding site [chemical binding]; other site 1138877001378 active site 1138877001379 putative substrate binding site [chemical binding]; other site 1138877001380 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1138877001381 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 1138877001382 putative acyl-acceptor binding pocket; other site 1138877001383 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1138877001384 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1138877001385 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138877001386 S-adenosylmethionine binding site [chemical binding]; other site 1138877001387 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1138877001388 active site 1138877001389 catalytic site [active] 1138877001390 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1138877001391 HAD-superfamily subfamily IB hydrolase, TIGR01490; Region: HAD-SF-IB-hyp1 1138877001392 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1138877001393 MMPL family; Region: MMPL; pfam03176 1138877001394 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1138877001395 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 1138877001396 glutamyl-tRNA reductase; Region: hemA; TIGR01035 1138877001397 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1138877001398 tRNA; other site 1138877001399 putative tRNA binding site [nucleotide binding]; other site 1138877001400 putative NADP binding site [chemical binding]; other site 1138877001401 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1138877001402 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1138877001403 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 1138877001404 domain interfaces; other site 1138877001405 active site 1138877001406 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 1138877001407 active site 1138877001408 homodimer interface [polypeptide binding]; other site 1138877001409 SAM binding site [chemical binding]; other site 1138877001410 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1138877001411 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1138877001412 active site 1138877001413 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1138877001414 dimer interface [polypeptide binding]; other site 1138877001415 active site 1138877001416 Schiff base residues; other site 1138877001417 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1138877001418 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1138877001419 active site 1138877001420 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1138877001421 anti sigma factor interaction site; other site 1138877001422 regulatory phosphorylation site [posttranslational modification]; other site 1138877001423 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1138877001424 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1138877001425 active site 1138877001426 catalytic triad [active] 1138877001427 oxyanion hole [active] 1138877001428 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 1138877001429 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138877001430 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1138877001431 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1138877001432 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1138877001433 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1138877001434 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1138877001435 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1138877001436 catalytic residue [active] 1138877001437 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1138877001438 catalytic core [active] 1138877001439 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1138877001440 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1138877001441 catalytic residues [active] 1138877001442 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1138877001443 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1138877001444 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 1138877001445 ResB-like family; Region: ResB; pfam05140 1138877001446 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 1138877001447 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1138877001448 AAA domain; Region: AAA_31; pfam13614 1138877001449 P-loop; other site 1138877001450 Magnesium ion binding site [ion binding]; other site 1138877001451 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1138877001452 Protein of unknown function (DUF4229); Region: DUF4229; pfam14012 1138877001453 3-oxoacyl-(acyl-carrier-protein) synthase III; Region: fabH; TIGR00747 1138877001454 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1138877001455 dimer interface [polypeptide binding]; other site 1138877001456 active site 1138877001457 CoA binding pocket [chemical binding]; other site 1138877001458 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Region: menA; TIGR00751 1138877001459 UbiA prenyltransferase family; Region: UbiA; pfam01040 1138877001460 5'-methylthioadenosine phosphorylase; Validated; Region: PRK07823 1138877001461 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1138877001462 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138877001463 NAD(P) binding site [chemical binding]; other site 1138877001464 active site 1138877001465 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1138877001466 Ligand binding site; other site 1138877001467 Putative Catalytic site; other site 1138877001468 DXD motif; other site 1138877001469 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3222 1138877001470 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 1138877001471 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138877001472 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138877001473 acyl-activating enzyme (AAE) consensus motif; other site 1138877001474 acyl-activating enzyme (AAE) consensus motif; other site 1138877001475 AMP binding site [chemical binding]; other site 1138877001476 active site 1138877001477 CoA binding site [chemical binding]; other site 1138877001478 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 1138877001479 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1138877001480 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1138877001481 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1138877001482 active site 1138877001483 short chain dehydrogenase; Provisional; Region: PRK05866 1138877001484 classical (c) SDRs; Region: SDR_c; cd05233 1138877001485 NAD(P) binding site [chemical binding]; other site 1138877001486 active site 1138877001487 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138877001488 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1138877001489 substrate binding site [chemical binding]; other site 1138877001490 oxyanion hole (OAH) forming residues; other site 1138877001491 trimer interface [polypeptide binding]; other site 1138877001492 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 1138877001493 putative active site [active] 1138877001494 homotetrameric interface [polypeptide binding]; other site 1138877001495 metal binding site [ion binding]; metal-binding site 1138877001496 Post-segregation antitoxin (ccd killing mechanism protein) encoded by the F plasmid [General function prediction only]; Region: COG5302 1138877001497 acyl-CoA synthetase; Validated; Region: PRK06188 1138877001498 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1138877001499 putative active site [active] 1138877001500 putative CoA binding site [chemical binding]; other site 1138877001501 putative AMP binding site [chemical binding]; other site 1138877001502 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1138877001503 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1138877001504 active site 1138877001505 O-succinylbenzoate synthase; Provisional; Region: PRK02901 1138877001506 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 1138877001507 active site 1138877001508 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138877001509 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1138877001510 TAP-like protein; Region: Abhydrolase_4; pfam08386 1138877001511 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 1138877001512 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1138877001513 dimer interface [polypeptide binding]; other site 1138877001514 tetramer interface [polypeptide binding]; other site 1138877001515 PYR/PP interface [polypeptide binding]; other site 1138877001516 TPP binding site [chemical binding]; other site 1138877001517 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1138877001518 TPP-binding site; other site 1138877001519 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 1138877001520 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1138877001521 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1138877001522 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1138877001523 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138877001524 S-adenosylmethionine binding site [chemical binding]; other site 1138877001525 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1138877001526 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1138877001527 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138877001528 S-adenosylmethionine binding site [chemical binding]; other site 1138877001529 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 1138877001530 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1138877001531 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1138877001532 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1138877001533 substrate binding pocket [chemical binding]; other site 1138877001534 chain length determination region; other site 1138877001535 substrate-Mg2+ binding site; other site 1138877001536 catalytic residues [active] 1138877001537 aspartate-rich region 1; other site 1138877001538 active site lid residues [active] 1138877001539 aspartate-rich region 2; other site 1138877001540 heat shock protein HtpX; Provisional; Region: PRK03072 1138877001541 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK12439 1138877001542 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1138877001543 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1138877001544 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1138877001545 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1138877001546 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 1138877001547 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1138877001548 O-methyltransferase; Region: Methyltransf_2; pfam00891 1138877001549 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138877001550 Cytochrome P450; Region: p450; cl12078 1138877001551 ATP cone domain; Region: ATP-cone; pfam03477 1138877001552 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 1138877001553 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 1138877001554 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 1138877001555 active site 1138877001556 dimer interface [polypeptide binding]; other site 1138877001557 effector binding site; other site 1138877001558 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1138877001559 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1138877001560 active site 1138877001561 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1138877001562 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1138877001563 nicotinate phosphoribosyltransferase; Provisional; Region: PRK12484 1138877001564 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1138877001565 active site 1138877001566 Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane]; Region: PgsA; COG2843 1138877001567 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 1138877001568 putative active site [active] 1138877001569 putative metal binding site [ion binding]; other site 1138877001570 hypothetical protein; Provisional; Region: PRK07588 1138877001571 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1138877001572 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1138877001573 dimerization interface [polypeptide binding]; other site 1138877001574 putative DNA binding site [nucleotide binding]; other site 1138877001575 putative Zn2+ binding site [ion binding]; other site 1138877001576 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1138877001577 putative hydrophobic ligand binding site [chemical binding]; other site 1138877001578 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1138877001579 TIGR03086 family protein; Region: TIGR03086 1138877001580 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1138877001581 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1138877001582 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1138877001583 PE family; Region: PE; pfam00934 1138877001584 Ub domain fused to Mut7-C; Region: Ub-Mut7C; pfam14451 1138877001585 Uncharacterized conserved protein [Function unknown]; Region: COG1656 1138877001586 Protein of unknown function DUF82; Region: DUF82; pfam01927 1138877001587 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1138877001588 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 1138877001589 putative active site [active] 1138877001590 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 1138877001591 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 1138877001592 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 1138877001593 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 1138877001594 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1138877001595 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1138877001596 DNA-binding site [nucleotide binding]; DNA binding site 1138877001597 FCD domain; Region: FCD; pfam07729 1138877001598 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1138877001599 Permease; Region: Permease; pfam02405 1138877001600 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1138877001601 Permease; Region: Permease; pfam02405 1138877001602 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138877001603 mce related protein; Region: MCE; pfam02470 1138877001604 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1138877001605 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1138877001606 mce related protein; Region: MCE; pfam02470 1138877001607 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1138877001608 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138877001609 mce related protein; Region: MCE; pfam02470 1138877001610 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138877001611 mce related protein; Region: MCE; pfam02470 1138877001612 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1138877001613 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138877001614 mce related protein; Region: MCE; pfam02470 1138877001615 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138877001616 mce related protein; Region: MCE; pfam02470 1138877001617 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1138877001618 oligomeric interface; other site 1138877001619 putative active site [active] 1138877001620 homodimer interface [polypeptide binding]; other site 1138877001621 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1138877001622 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 1138877001623 AAA domain; Region: AAA_14; pfam13173 1138877001624 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1138877001625 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 1138877001626 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1138877001627 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1138877001628 ATP binding site [chemical binding]; other site 1138877001629 Mg2+ binding site [ion binding]; other site 1138877001630 G-X-G motif; other site 1138877001631 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1138877001632 dimerization interface [polypeptide binding]; other site 1138877001633 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1138877001634 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1138877001635 active site 1138877001636 phosphorylation site [posttranslational modification] 1138877001637 intermolecular recognition site; other site 1138877001638 dimerization interface [polypeptide binding]; other site 1138877001639 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1138877001640 DNA binding site [nucleotide binding] 1138877001641 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 1138877001642 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 1138877001643 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 1138877001644 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 1138877001645 catalytic residues [active] 1138877001646 catalytic nucleophile [active] 1138877001647 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1138877001648 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1138877001649 Probable transposase; Region: OrfB_IS605; pfam01385 1138877001650 Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704 1138877001651 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 1138877001652 putative active site [active] 1138877001653 SEC-C motif; Region: SEC-C; pfam02810 1138877001654 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB-like; cd09875 1138877001655 putative active site [active] 1138877001656 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 1138877001657 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 1138877001658 nucleotide binding site/active site [active] 1138877001659 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 1138877001660 galactokinase; Provisional; Region: PRK00555 1138877001661 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1138877001662 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1138877001663 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4423 1138877001664 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 1138877001665 putative active site [active] 1138877001666 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1138877001667 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1138877001668 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1138877001669 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1138877001670 oligomeric interface; other site 1138877001671 putative active site [active] 1138877001672 homodimer interface [polypeptide binding]; other site 1138877001673 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398 1138877001674 FIST N domain; Region: FIST; pfam08495 1138877001675 FIST C domain; Region: FIST_C; pfam10442 1138877001676 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 1138877001677 AAA domain; Region: AAA_30; pfam13604 1138877001678 Family description; Region: UvrD_C_2; pfam13538 1138877001679 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 1138877001680 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1138877001681 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 1138877001682 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 1138877001683 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1138877001684 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138877001685 substrate binding site [chemical binding]; other site 1138877001686 oxyanion hole (OAH) forming residues; other site 1138877001687 trimer interface [polypeptide binding]; other site 1138877001688 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1138877001689 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 1138877001690 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 1138877001691 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1138877001692 active site 1138877001693 catalytic site [active] 1138877001694 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 1138877001695 active site 1138877001696 catalytic site [active] 1138877001697 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1138877001698 active site 1138877001699 catalytic site [active] 1138877001700 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 1138877001701 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1138877001702 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1138877001703 putative homodimer interface [polypeptide binding]; other site 1138877001704 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1138877001705 heterodimer interface [polypeptide binding]; other site 1138877001706 homodimer interface [polypeptide binding]; other site 1138877001707 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1138877001708 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1138877001709 23S rRNA interface [nucleotide binding]; other site 1138877001710 L7/L12 interface [polypeptide binding]; other site 1138877001711 putative thiostrepton binding site; other site 1138877001712 L25 interface [polypeptide binding]; other site 1138877001713 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1138877001714 mRNA/rRNA interface [nucleotide binding]; other site 1138877001715 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1138877001716 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138877001717 S-adenosylmethionine binding site [chemical binding]; other site 1138877001718 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1138877001719 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1138877001720 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138877001721 S-adenosylmethionine binding site [chemical binding]; other site 1138877001722 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1138877001723 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1138877001724 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138877001725 S-adenosylmethionine binding site [chemical binding]; other site 1138877001726 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1138877001727 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1138877001728 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138877001729 S-adenosylmethionine binding site [chemical binding]; other site 1138877001730 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138877001731 TAP-like protein; Region: Abhydrolase_4; pfam08386 1138877001732 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 1138877001733 ABC1 family; Region: ABC1; cl17513 1138877001734 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 1138877001735 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 1138877001736 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 1138877001737 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 1138877001738 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1138877001739 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1138877001740 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1138877001741 23S rRNA interface [nucleotide binding]; other site 1138877001742 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1138877001743 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1138877001744 core dimer interface [polypeptide binding]; other site 1138877001745 peripheral dimer interface [polypeptide binding]; other site 1138877001746 L10 interface [polypeptide binding]; other site 1138877001747 L11 interface [polypeptide binding]; other site 1138877001748 putative EF-Tu interaction site [polypeptide binding]; other site 1138877001749 putative EF-G interaction site [polypeptide binding]; other site 1138877001750 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138877001751 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138877001752 WHG domain; Region: WHG; pfam13305 1138877001753 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 1138877001754 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 1138877001755 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1138877001756 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1138877001757 Walker A/P-loop; other site 1138877001758 ATP binding site [chemical binding]; other site 1138877001759 Q-loop/lid; other site 1138877001760 ABC transporter signature motif; other site 1138877001761 Walker B; other site 1138877001762 D-loop; other site 1138877001763 H-loop/switch region; other site 1138877001764 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1138877001765 putative active site [active] 1138877001766 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 1138877001767 Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266 1138877001768 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 1138877001769 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG1848 1138877001770 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1138877001771 Sulfatase; Region: Sulfatase; pfam00884 1138877001772 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1138877001773 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1138877001774 putative active site [active] 1138877001775 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1138877001776 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1138877001777 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1138877001778 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1138877001779 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1138877001780 RPB10 interaction site [polypeptide binding]; other site 1138877001781 RPB1 interaction site [polypeptide binding]; other site 1138877001782 RPB11 interaction site [polypeptide binding]; other site 1138877001783 RPB3 interaction site [polypeptide binding]; other site 1138877001784 RPB12 interaction site [polypeptide binding]; other site 1138877001785 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1138877001786 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1138877001787 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1138877001788 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1138877001789 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 1138877001790 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1138877001791 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 1138877001792 G-loop; other site 1138877001793 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1138877001794 DNA binding site [nucleotide binding] 1138877001795 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1138877001796 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; pfam04734 1138877001797 endonuclease IV; Provisional; Region: PRK01060 1138877001798 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1138877001799 AP (apurinic/apyrimidinic) site pocket; other site 1138877001800 DNA interaction; other site 1138877001801 Metal-binding active site; metal-binding site 1138877001802 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 1138877001803 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 1138877001804 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 1138877001805 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138877001806 active site 1138877001807 enoyl-CoA hydratase; Provisional; Region: PRK12478 1138877001808 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138877001809 substrate binding site [chemical binding]; other site 1138877001810 oxyanion hole (OAH) forming residues; other site 1138877001811 trimer interface [polypeptide binding]; other site 1138877001812 Phenylacetic acid-responsive transcriptional repressor [Transcription]; Region: PaaX; COG3327 1138877001813 PaaX-like protein; Region: PaaX; pfam07848 1138877001814 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 1138877001815 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1138877001816 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138877001817 substrate binding site [chemical binding]; other site 1138877001818 oxyanion hole (OAH) forming residues; other site 1138877001819 trimer interface [polypeptide binding]; other site 1138877001820 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1138877001821 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1138877001822 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 1138877001823 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 1138877001824 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138877001825 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138877001826 WHG domain; Region: WHG; pfam13305 1138877001827 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1138877001828 S17 interaction site [polypeptide binding]; other site 1138877001829 S8 interaction site; other site 1138877001830 16S rRNA interaction site [nucleotide binding]; other site 1138877001831 streptomycin interaction site [chemical binding]; other site 1138877001832 23S rRNA interaction site [nucleotide binding]; other site 1138877001833 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1138877001834 30S ribosomal protein S7; Validated; Region: PRK05302 1138877001835 elongation factor G; Reviewed; Region: PRK00007 1138877001836 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1138877001837 G1 box; other site 1138877001838 putative GEF interaction site [polypeptide binding]; other site 1138877001839 GTP/Mg2+ binding site [chemical binding]; other site 1138877001840 Switch I region; other site 1138877001841 G2 box; other site 1138877001842 G3 box; other site 1138877001843 Switch II region; other site 1138877001844 G4 box; other site 1138877001845 G5 box; other site 1138877001846 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1138877001847 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1138877001848 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1138877001849 elongation factor Tu; Reviewed; Region: PRK00049 1138877001850 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1138877001851 G1 box; other site 1138877001852 GEF interaction site [polypeptide binding]; other site 1138877001853 GTP/Mg2+ binding site [chemical binding]; other site 1138877001854 Switch I region; other site 1138877001855 G2 box; other site 1138877001856 G3 box; other site 1138877001857 Switch II region; other site 1138877001858 G4 box; other site 1138877001859 G5 box; other site 1138877001860 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 1138877001861 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1138877001862 Antibiotic Binding Site [chemical binding]; other site 1138877001863 Short C-terminal domain; Region: SHOCT; pfam09851 1138877001864 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1138877001865 classical (c) SDRs; Region: SDR_c; cd05233 1138877001866 NAD(P) binding site [chemical binding]; other site 1138877001867 active site 1138877001868 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1138877001869 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1138877001870 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4427 1138877001871 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1138877001872 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138877001873 putative mycofactocin binding protein MftB; Region: mycofact_MftB; TIGR03967 1138877001874 mycofactocin radical SAM maturase; Region: mycofact_rSAM; TIGR03962 1138877001875 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1138877001876 FeS/SAM binding site; other site 1138877001877 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1138877001878 heme/flavin dehydrogenase, mycofactocin system; Region: actino_HemFlav; TIGR03966 1138877001879 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1138877001880 phosphate binding site [ion binding]; other site 1138877001881 mycofactocin system creatininase family protein; Region: mycofact_creat; TIGR03964 1138877001882 mycofactocin system glycosyltransferase; Region: mycofact_glyco; TIGR03965 1138877001883 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1138877001884 Probable Catalytic site; other site 1138877001885 metal-binding site 1138877001886 dehydrogenase, Rv0697 family; Region: Rv0697; TIGR03970 1138877001887 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1138877001888 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1138877001889 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1138877001890 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1138877001891 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1138877001892 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1138877001893 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1138877001894 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1138877001895 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1138877001896 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1138877001897 putative translocon binding site; other site 1138877001898 protein-rRNA interface [nucleotide binding]; other site 1138877001899 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1138877001900 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1138877001901 G-X-X-G motif; other site 1138877001902 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1138877001903 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1138877001904 23S rRNA interface [nucleotide binding]; other site 1138877001905 5S rRNA interface [nucleotide binding]; other site 1138877001906 putative antibiotic binding site [chemical binding]; other site 1138877001907 L25 interface [polypeptide binding]; other site 1138877001908 L27 interface [polypeptide binding]; other site 1138877001909 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1138877001910 putative translocon interaction site; other site 1138877001911 23S rRNA interface [nucleotide binding]; other site 1138877001912 signal recognition particle (SRP54) interaction site; other site 1138877001913 L23 interface [polypeptide binding]; other site 1138877001914 trigger factor interaction site; other site 1138877001915 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1138877001916 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1138877001917 Sulfatase; Region: Sulfatase; pfam00884 1138877001918 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl17353 1138877001919 Uncharacterized conserved protein [Function unknown]; Region: COG1262 1138877001920 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1138877001921 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1138877001922 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1138877001923 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1138877001924 RNA binding site [nucleotide binding]; other site 1138877001925 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1138877001926 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1138877001927 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1138877001928 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 1138877001929 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1138877001930 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1138877001931 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1138877001932 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1138877001933 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1138877001934 5S rRNA interface [nucleotide binding]; other site 1138877001935 23S rRNA interface [nucleotide binding]; other site 1138877001936 L5 interface [polypeptide binding]; other site 1138877001937 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1138877001938 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1138877001939 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1138877001940 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1138877001941 23S rRNA binding site [nucleotide binding]; other site 1138877001942 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1138877001943 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 1138877001944 tandem repeat interface [polypeptide binding]; other site 1138877001945 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1138877001946 oligomer interface [polypeptide binding]; other site 1138877001947 active site residues [active] 1138877001948 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1138877001949 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1138877001950 tandem repeat interface [polypeptide binding]; other site 1138877001951 oligomer interface [polypeptide binding]; other site 1138877001952 active site residues [active] 1138877001953 Leucine carboxyl methyltransferase; Region: LCM; cl01306 1138877001954 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138877001955 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1138877001956 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138877001957 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1138877001958 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1138877001959 intersubunit interface [polypeptide binding]; other site 1138877001960 active site 1138877001961 Zn2+ binding site [ion binding]; other site 1138877001962 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1138877001963 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1138877001964 NAD binding site [chemical binding]; other site 1138877001965 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1138877001966 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1138877001967 nucleotide binding site [chemical binding]; other site 1138877001968 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1138877001969 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1138877001970 Coenzyme A binding pocket [chemical binding]; other site 1138877001971 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138877001972 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1138877001973 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1138877001974 SecY translocase; Region: SecY; pfam00344 1138877001975 adenylate kinase; Reviewed; Region: adk; PRK00279 1138877001976 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1138877001977 AMP-binding site [chemical binding]; other site 1138877001978 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1138877001979 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1138877001980 active site 1138877001981 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 1138877001982 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1138877001983 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1138877001984 DNA binding residues [nucleotide binding] 1138877001985 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 1138877001986 Putative zinc-finger; Region: zf-HC2; pfam13490 1138877001987 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1138877001988 MarR family; Region: MarR; pfam01047 1138877001989 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1138877001990 TIGR03086 family protein; Region: TIGR03086 1138877001991 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 1138877001992 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1138877001993 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1138877001994 Helix-turn-helix domain; Region: HTH_17; pfam12728 1138877001995 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 1138877001996 PE family; Region: PE; pfam00934 1138877001997 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1138877001998 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 1138877001999 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1138877002000 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 1138877002001 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138877002002 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138877002003 active site 1138877002004 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1138877002005 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1138877002006 tetrameric interface [polypeptide binding]; other site 1138877002007 NAD binding site [chemical binding]; other site 1138877002008 catalytic residues [active] 1138877002009 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1138877002010 catalytic core [active] 1138877002011 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138877002012 PPE family; Region: PPE; pfam00823 1138877002013 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1138877002014 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1138877002015 Helix-turn-helix domain; Region: HTH_28; pfam13518 1138877002016 Winged helix-turn helix; Region: HTH_29; pfam13551 1138877002017 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1138877002018 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1138877002019 active site 1138877002020 phosphorylation site [posttranslational modification] 1138877002021 intermolecular recognition site; other site 1138877002022 dimerization interface [polypeptide binding]; other site 1138877002023 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1138877002024 DNA binding site [nucleotide binding] 1138877002025 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1138877002026 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1138877002027 dimerization interface [polypeptide binding]; other site 1138877002028 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1138877002029 dimer interface [polypeptide binding]; other site 1138877002030 phosphorylation site [posttranslational modification] 1138877002031 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1138877002032 ATP binding site [chemical binding]; other site 1138877002033 Mg2+ binding site [ion binding]; other site 1138877002034 G-X-G motif; other site 1138877002035 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 1138877002036 nucleotide binding site/active site [active] 1138877002037 HIT family signature motif; other site 1138877002038 catalytic residue [active] 1138877002039 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 1138877002040 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 1138877002041 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1138877002042 NAD binding site [chemical binding]; other site 1138877002043 catalytic Zn binding site [ion binding]; other site 1138877002044 substrate binding site [chemical binding]; other site 1138877002045 structural Zn binding site [ion binding]; other site 1138877002046 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1138877002047 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1138877002048 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 1138877002049 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138877002050 Cytochrome P450; Region: p450; cl12078 1138877002051 short chain dehydrogenase; Provisional; Region: PRK07775 1138877002052 classical (c) SDRs; Region: SDR_c; cd05233 1138877002053 NAD(P) binding site [chemical binding]; other site 1138877002054 active site 1138877002055 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138877002056 Cytochrome P450; Region: p450; cl12078 1138877002057 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138877002058 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 1138877002059 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 1138877002060 NAD binding site [chemical binding]; other site 1138877002061 catalytic residues [active] 1138877002062 short chain dehydrogenase; Provisional; Region: PRK07774 1138877002063 classical (c) SDRs; Region: SDR_c; cd05233 1138877002064 NAD(P) binding site [chemical binding]; other site 1138877002065 active site 1138877002066 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1138877002067 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 1138877002068 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1138877002069 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1138877002070 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1138877002071 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1138877002072 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1138877002073 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1138877002074 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1138877002075 Predicted esterase [General function prediction only]; Region: COG0627 1138877002076 S-formylglutathione hydrolase; Region: PLN02442 1138877002077 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 1138877002078 Predicted nuclease (RNAse H fold) [General function prediction only]; Region: COG4328 1138877002079 Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302 1138877002080 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 1138877002081 tetramer interface [polypeptide binding]; other site 1138877002082 active site 1138877002083 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138877002084 Cytochrome P450; Region: p450; cl12078 1138877002085 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 1138877002086 ATP binding site [chemical binding]; other site 1138877002087 active site 1138877002088 substrate binding site [chemical binding]; other site 1138877002089 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 1138877002090 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1138877002091 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1138877002092 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138877002093 putative substrate translocation pore; other site 1138877002094 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138877002095 Predicted deacetylase [General function prediction only]; Region: COG3233 1138877002096 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374 1138877002097 putative active site [active] 1138877002098 putative Zn binding site [ion binding]; other site 1138877002099 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1138877002100 FAD binding domain; Region: FAD_binding_2; pfam00890 1138877002101 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1138877002102 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 1138877002103 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1138877002104 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1138877002105 putative active site [active] 1138877002106 catalytic triad [active] 1138877002107 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1138877002108 Transglutaminase/protease-like homologues; Region: TGc; smart00460 1138877002109 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1138877002110 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 1138877002111 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1138877002112 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1138877002113 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1138877002114 DNA-binding site [nucleotide binding]; DNA binding site 1138877002115 UTRA domain; Region: UTRA; pfam07702 1138877002116 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1138877002117 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 1138877002118 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1138877002119 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1138877002120 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1138877002121 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1138877002122 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1138877002123 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1138877002124 Uncharacterized protein, linocin/CFP29 homolog [Function unknown]; Region: COG1659 1138877002125 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 1138877002126 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 1138877002127 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 1138877002128 active site 1138877002129 metal binding site [ion binding]; metal-binding site 1138877002130 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1138877002131 active site 1138877002132 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1138877002133 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1138877002134 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1138877002135 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1138877002136 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1138877002137 dimerization interface [polypeptide binding]; other site 1138877002138 ATP binding site [chemical binding]; other site 1138877002139 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1138877002140 dimerization interface [polypeptide binding]; other site 1138877002141 ATP binding site [chemical binding]; other site 1138877002142 CAAX protease self-immunity; Region: Abi; pfam02517 1138877002143 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 1138877002144 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 1138877002145 active site 1138877002146 metal binding site [ion binding]; metal-binding site 1138877002147 hexamer interface [polypeptide binding]; other site 1138877002148 Protein of unknown function (DUF3184); Region: DUF3184; pfam11380 1138877002149 amidophosphoribosyltransferase; Provisional; Region: PRK07847 1138877002150 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1138877002151 active site 1138877002152 tetramer interface [polypeptide binding]; other site 1138877002153 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1138877002154 active site 1138877002155 phosphoribosylaminoimidazole synthetase; Region: purM; TIGR00878 1138877002156 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1138877002157 dimerization interface [polypeptide binding]; other site 1138877002158 putative ATP binding site [chemical binding]; other site 1138877002159 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 1138877002160 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 1138877002161 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1138877002162 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1138877002163 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1138877002164 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138877002165 catalytic residue [active] 1138877002166 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 1138877002167 heme-binding site [chemical binding]; other site 1138877002168 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 1138877002169 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1138877002170 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1138877002171 active site residue [active] 1138877002172 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1138877002173 active site residue [active] 1138877002174 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1138877002175 catalytic residues [active] 1138877002176 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1138877002177 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1138877002178 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1138877002179 DNA binding site [nucleotide binding] 1138877002180 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 1138877002181 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1138877002182 Coenzyme A binding pocket [chemical binding]; other site 1138877002183 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 1138877002184 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1138877002185 Walker A/P-loop; other site 1138877002186 ATP binding site [chemical binding]; other site 1138877002187 Q-loop/lid; other site 1138877002188 ABC transporter signature motif; other site 1138877002189 Walker B; other site 1138877002190 D-loop; other site 1138877002191 H-loop/switch region; other site 1138877002192 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1138877002193 PhoU domain; Region: PhoU; pfam01895 1138877002194 PhoU domain; Region: PhoU; pfam01895 1138877002195 cell envelope-related function transcriptional attenuator common domain; Region: lytR_cpsA_psr; TIGR00350 1138877002196 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1138877002197 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1138877002198 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1138877002199 FMN binding site [chemical binding]; other site 1138877002200 active site 1138877002201 catalytic residues [active] 1138877002202 substrate binding site [chemical binding]; other site 1138877002203 Fatty acid desaturase; Region: FA_desaturase_2; pfam03405 1138877002204 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 1138877002205 homodimer interface [polypeptide binding]; other site 1138877002206 putative substrate binding pocket [chemical binding]; other site 1138877002207 diiron center [ion binding]; other site 1138877002208 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138877002209 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 1138877002210 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1138877002211 dimerization interface [polypeptide binding]; other site 1138877002212 putative DNA binding site [nucleotide binding]; other site 1138877002213 putative Zn2+ binding site [ion binding]; other site 1138877002214 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1138877002215 dimer interface [polypeptide binding]; other site 1138877002216 catalytic motif [active] 1138877002217 nucleoside/Zn binding site; other site 1138877002218 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1138877002219 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138877002220 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1138877002221 TIGR04255 family protein; Region: sporadTIGR04255 1138877002222 PE family; Region: PE; pfam00934 1138877002223 PE family; Region: PE; pfam00934 1138877002224 PknH-like extracellular domain; Region: PknH_C; pfam14032 1138877002225 Predicted nucleotidyltransferase [General function prediction only]; Region: COG4849 1138877002226 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4861 1138877002227 Uncharacterized protein conserved in bacteria (DUF2186); Region: DUF2186; pfam09952 1138877002228 D-ala-D-ala dipeptidase; Region: Peptidase_M15; pfam01427 1138877002229 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138877002230 S-adenosylmethionine binding site [chemical binding]; other site 1138877002231 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 1138877002232 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138877002233 putative substrate translocation pore; other site 1138877002234 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1138877002235 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 1138877002236 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1138877002237 tetramer interface [polypeptide binding]; other site 1138877002238 TPP-binding site [chemical binding]; other site 1138877002239 heterodimer interface [polypeptide binding]; other site 1138877002240 phosphorylation loop region [posttranslational modification] 1138877002241 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1138877002242 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1138877002243 active site 1138877002244 phosphorylation site [posttranslational modification] 1138877002245 intermolecular recognition site; other site 1138877002246 dimerization interface [polypeptide binding]; other site 1138877002247 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1138877002248 DNA binding residues [nucleotide binding] 1138877002249 dimerization interface [polypeptide binding]; other site 1138877002250 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1138877002251 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1138877002252 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1138877002253 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1138877002254 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1138877002255 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1138877002256 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1138877002257 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1138877002258 dimer interface [polypeptide binding]; other site 1138877002259 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138877002260 catalytic residue [active] 1138877002261 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138877002262 multidrug resistance protein MdtH; Provisional; Region: PRK11646 1138877002263 putative substrate translocation pore; other site 1138877002264 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 1138877002265 short chain dehydrogenase; Provisional; Region: PRK05876 1138877002266 classical (c) SDRs; Region: SDR_c; cd05233 1138877002267 NAD(P) binding site [chemical binding]; other site 1138877002268 active site 1138877002269 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138877002270 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 1138877002271 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 1138877002272 dimer interface [polypeptide binding]; other site 1138877002273 PYR/PP interface [polypeptide binding]; other site 1138877002274 TPP binding site [chemical binding]; other site 1138877002275 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1138877002276 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 1138877002277 TPP-binding site [chemical binding]; other site 1138877002278 dimer interface [polypeptide binding]; other site 1138877002279 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1138877002280 putative hydrophobic ligand binding site [chemical binding]; other site 1138877002281 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1138877002282 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1138877002283 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1138877002284 putative hydrophobic ligand binding site [chemical binding]; other site 1138877002285 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1138877002286 putative hydrophobic ligand binding site [chemical binding]; other site 1138877002287 aminotransferase; Validated; Region: PRK07777 1138877002288 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1138877002289 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138877002290 homodimer interface [polypeptide binding]; other site 1138877002291 catalytic residue [active] 1138877002292 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 1138877002293 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1138877002294 dimer interface [polypeptide binding]; other site 1138877002295 active site 1138877002296 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 1138877002297 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138877002298 substrate binding site [chemical binding]; other site 1138877002299 oxyanion hole (OAH) forming residues; other site 1138877002300 trimer interface [polypeptide binding]; other site 1138877002301 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1138877002302 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1138877002303 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1138877002304 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1138877002305 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1138877002306 ATP binding site [chemical binding]; other site 1138877002307 putative Mg++ binding site [ion binding]; other site 1138877002308 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1138877002309 nucleotide binding region [chemical binding]; other site 1138877002310 ATP-binding site [chemical binding]; other site 1138877002311 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1138877002312 WYL domain; Region: WYL; pfam13280 1138877002313 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1138877002314 trimer interface [polypeptide binding]; other site 1138877002315 dimer interface [polypeptide binding]; other site 1138877002316 putative active site [active] 1138877002317 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1138877002318 MPT binding site; other site 1138877002319 trimer interface [polypeptide binding]; other site 1138877002320 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1138877002321 MoaE homodimer interface [polypeptide binding]; other site 1138877002322 MoaD interaction [polypeptide binding]; other site 1138877002323 active site residues [active] 1138877002324 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1138877002325 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1138877002326 MoaE interaction surface [polypeptide binding]; other site 1138877002327 MoeB interaction surface [polypeptide binding]; other site 1138877002328 thiocarboxylated glycine; other site 1138877002329 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1138877002330 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1138877002331 FeS/SAM binding site; other site 1138877002332 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1138877002333 hypothetical protein; Provisional; Region: PRK11770 1138877002334 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1138877002335 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1138877002336 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1138877002337 DNA-binding site [nucleotide binding]; DNA binding site 1138877002338 RNA-binding motif; other site 1138877002339 PE family; Region: PE; pfam00934 1138877002340 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138877002341 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138877002342 active site 1138877002343 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398 1138877002344 FIST N domain; Region: FIST; pfam08495 1138877002345 FIST C domain; Region: FIST_C; pfam10442 1138877002346 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 1138877002347 H+ Antiporter protein; Region: 2A0121; TIGR00900 1138877002348 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 1138877002349 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138877002350 PPE family; Region: PPE; pfam00823 1138877002351 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1138877002352 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1138877002353 Protein of unknown function (DUF2530); Region: DUF2530; pfam10745 1138877002354 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1138877002355 MarR family; Region: MarR; pfam01047 1138877002356 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1138877002357 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1138877002358 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1138877002359 Protein of unknown function (DUF2537); Region: DUF2537; pfam10801 1138877002360 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 1138877002361 phosphoserine aminotransferase, putative; Region: serC_3; TIGR01366 1138877002362 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1138877002363 catalytic residue [active] 1138877002364 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 1138877002365 Ferredoxin [Energy production and conversion]; Region: COG1146 1138877002366 4Fe-4S binding domain; Region: Fer4; pfam00037 1138877002367 ferredoxin-NADP+ reductase; Region: PLN02852 1138877002368 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1138877002369 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 1138877002370 putative dimer interface [polypeptide binding]; other site 1138877002371 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1138877002372 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1138877002373 putative catalytic site [active] 1138877002374 putative phosphate binding site [ion binding]; other site 1138877002375 putative metal binding site [ion binding]; other site 1138877002376 Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109 1138877002377 dimer interface [polypeptide binding]; other site 1138877002378 Citrate synthase; Region: Citrate_synt; pfam00285 1138877002379 active site 1138877002380 citrylCoA binding site [chemical binding]; other site 1138877002381 oxalacetate/citrate binding site [chemical binding]; other site 1138877002382 coenzyme A binding site [chemical binding]; other site 1138877002383 catalytic triad [active] 1138877002384 Predicted ATPase [General function prediction only]; Region: COG3903 1138877002385 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1138877002386 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1138877002387 DNA binding residues [nucleotide binding] 1138877002388 dimerization interface [polypeptide binding]; other site 1138877002389 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1138877002390 cyclase homology domain; Region: CHD; cd07302 1138877002391 nucleotidyl binding site; other site 1138877002392 metal binding site [ion binding]; metal-binding site 1138877002393 dimer interface [polypeptide binding]; other site 1138877002394 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1138877002395 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1138877002396 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138877002397 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1138877002398 AAA ATPase domain; Region: AAA_16; pfam13191 1138877002399 Predicted ATPase [General function prediction only]; Region: COG3903 1138877002400 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1138877002401 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1138877002402 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1138877002403 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1138877002404 dimer interface [polypeptide binding]; other site 1138877002405 active site 1138877002406 citrylCoA binding site [chemical binding]; other site 1138877002407 NADH binding [chemical binding]; other site 1138877002408 cationic pore residues; other site 1138877002409 oxalacetate/citrate binding site [chemical binding]; other site 1138877002410 coenzyme A binding site [chemical binding]; other site 1138877002411 catalytic triad [active] 1138877002412 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1138877002413 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1138877002414 Protein of unknown function (DUF2630); Region: DUF2630; pfam10944 1138877002415 BON domain; Region: BON; pfam04972 1138877002416 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1138877002417 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1138877002418 ligand binding site [chemical binding]; other site 1138877002419 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 1138877002420 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1138877002421 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1138877002422 dimerization interface [polypeptide binding]; other site 1138877002423 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1138877002424 dimer interface [polypeptide binding]; other site 1138877002425 phosphorylation site [posttranslational modification] 1138877002426 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1138877002427 Mg2+ binding site [ion binding]; other site 1138877002428 G-X-G motif; other site 1138877002429 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1138877002430 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1138877002431 active site 1138877002432 phosphorylation site [posttranslational modification] 1138877002433 intermolecular recognition site; other site 1138877002434 dimerization interface [polypeptide binding]; other site 1138877002435 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1138877002436 DNA binding site [nucleotide binding] 1138877002437 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 1138877002438 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; COG0825 1138877002439 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1138877002440 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138877002441 substrate binding site [chemical binding]; other site 1138877002442 oxyanion hole (OAH) forming residues; other site 1138877002443 trimer interface [polypeptide binding]; other site 1138877002444 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1138877002445 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1138877002446 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1138877002447 Beta-lactamase; Region: Beta-lactamase; pfam00144 1138877002448 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 1138877002449 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1138877002450 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1138877002451 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1138877002452 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 1138877002453 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1138877002454 hydrophobic ligand binding site; other site 1138877002455 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1138877002456 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1138877002457 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1138877002458 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1138877002459 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 1138877002460 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 1138877002461 acetyl-CoA acetyltransferase; Provisional; Region: PRK06289 1138877002462 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1138877002463 active site 1138877002464 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138877002465 PPE family; Region: PPE; pfam00823 1138877002466 PE family; Region: PE; pfam00934 1138877002467 BCCT family transporter; Region: BCCT; pfam02028 1138877002468 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 1138877002469 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1138877002470 Coenzyme A binding pocket [chemical binding]; other site 1138877002471 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1138877002472 MULE transposase domain; Region: MULE; pfam10551 1138877002473 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 1138877002474 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 1138877002475 catalytic residues [active] 1138877002476 catalytic nucleophile [active] 1138877002477 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1138877002478 Probable transposase; Region: OrfB_IS605; pfam01385 1138877002479 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1138877002480 putative active site pocket [active] 1138877002481 dimerization interface [polypeptide binding]; other site 1138877002482 putative catalytic residue [active] 1138877002483 Phage-related replication protein [General function prediction only]; Region: COG4195 1138877002484 manganese transport protein MntH; Reviewed; Region: PRK00701 1138877002485 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1138877002486 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1138877002487 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1138877002488 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1138877002489 short chain dehydrogenase; Provisional; Region: PRK07814 1138877002490 classical (c) SDRs; Region: SDR_c; cd05233 1138877002491 NAD(P) binding site [chemical binding]; other site 1138877002492 active site 1138877002493 phosphate ABC transporter, phosphate-binding protein; Region: 3a0107s03; TIGR00975 1138877002494 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 1138877002495 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1138877002496 dimer interface [polypeptide binding]; other site 1138877002497 conserved gate region; other site 1138877002498 putative PBP binding loops; other site 1138877002499 ABC-ATPase subunit interface; other site 1138877002500 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1138877002501 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1138877002502 dimer interface [polypeptide binding]; other site 1138877002503 conserved gate region; other site 1138877002504 putative PBP binding loops; other site 1138877002505 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1138877002506 ABC-ATPase subunit interface; other site 1138877002507 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1138877002508 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1138877002509 active site 1138877002510 ATP binding site [chemical binding]; other site 1138877002511 substrate binding site [chemical binding]; other site 1138877002512 activation loop (A-loop); other site 1138877002513 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1138877002514 NHL repeat; Region: NHL; pfam01436 1138877002515 NHL repeat; Region: NHL; pfam01436 1138877002516 NHL repeat; Region: NHL; pfam01436 1138877002517 NHL repeat; Region: NHL; pfam01436 1138877002518 NHL repeat; Region: NHL; pfam01436 1138877002519 PBP superfamily domain; Region: PBP_like_2; cl17296 1138877002520 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14271 1138877002521 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1138877002522 Walker A/P-loop; other site 1138877002523 ATP binding site [chemical binding]; other site 1138877002524 Q-loop/lid; other site 1138877002525 ABC transporter signature motif; other site 1138877002526 Walker B; other site 1138877002527 D-loop; other site 1138877002528 H-loop/switch region; other site 1138877002529 phosphate ABC transporter, phosphate-binding protein; Region: 3a0107s03; TIGR00975 1138877002530 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 1138877002531 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1138877002532 dimer interface [polypeptide binding]; other site 1138877002533 conserved gate region; other site 1138877002534 putative PBP binding loops; other site 1138877002535 ABC-ATPase subunit interface; other site 1138877002536 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1138877002537 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1138877002538 dimer interface [polypeptide binding]; other site 1138877002539 conserved gate region; other site 1138877002540 putative PBP binding loops; other site 1138877002541 ABC-ATPase subunit interface; other site 1138877002542 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 1138877002543 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 1138877002544 putative DNA binding site [nucleotide binding]; other site 1138877002545 putative homodimer interface [polypeptide binding]; other site 1138877002546 ATP-dependent DNA ligase; Reviewed; Region: PRK09632 1138877002547 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 1138877002548 nucleotide binding site [chemical binding]; other site 1138877002549 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 1138877002550 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 1138877002551 active site 1138877002552 DNA binding site [nucleotide binding] 1138877002553 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 1138877002554 DNA binding site [nucleotide binding] 1138877002555 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1138877002556 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1138877002557 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1138877002558 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1138877002559 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1138877002560 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1138877002561 anti sigma factor interaction site; other site 1138877002562 regulatory phosphorylation site [posttranslational modification]; other site 1138877002563 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1138877002564 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1138877002565 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1138877002566 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1138877002567 short chain dehydrogenase; Provisional; Region: PRK08251 1138877002568 classical (c) SDR, subgroup 6; Region: SDR_c6; cd05350 1138877002569 putative NAD(P) binding site [chemical binding]; other site 1138877002570 active site 1138877002571 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1138877002572 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1138877002573 active site 1138877002574 dimer interface [polypeptide binding]; other site 1138877002575 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1138877002576 dimer interface [polypeptide binding]; other site 1138877002577 active site 1138877002578 hypothetical protein; Provisional; Region: PRK07857 1138877002579 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1138877002580 Part of AAA domain; Region: AAA_19; pfam13245 1138877002581 Family description; Region: UvrD_C_2; pfam13538 1138877002582 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1138877002583 Peptidase family M23; Region: Peptidase_M23; pfam01551 1138877002584 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1138877002585 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1138877002586 CoA-ligase; Region: Ligase_CoA; pfam00549 1138877002587 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1138877002588 CoA binding domain; Region: CoA_binding; smart00881 1138877002589 CoA-ligase; Region: Ligase_CoA; pfam00549 1138877002590 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1138877002591 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1138877002592 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1138877002593 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1138877002594 active site 1138877002595 substrate binding site [chemical binding]; other site 1138877002596 cosubstrate binding site; other site 1138877002597 catalytic site [active] 1138877002598 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1138877002599 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1138877002600 purine monophosphate binding site [chemical binding]; other site 1138877002601 dimer interface [polypeptide binding]; other site 1138877002602 putative catalytic residues [active] 1138877002603 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1138877002604 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1138877002605 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 1138877002606 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1138877002607 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 1138877002608 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1138877002609 metal ion-dependent adhesion site (MIDAS); other site 1138877002610 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 1138877002611 homotetrameric interface [polypeptide binding]; other site 1138877002612 putative active site [active] 1138877002613 metal binding site [ion binding]; metal-binding site 1138877002614 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 1138877002615 putative transposase OrfB; Reviewed; Region: PHA02517 1138877002616 HTH-like domain; Region: HTH_21; pfam13276 1138877002617 Integrase core domain; Region: rve; pfam00665 1138877002618 Integrase core domain; Region: rve_3; pfam13683 1138877002619 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1138877002620 Transposase; Region: HTH_Tnp_1; cl17663 1138877002621 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1138877002622 Thermus thermophilus CsoR, a Cu(I)-sensing transcriptional regulator, and related domains; this domain family was previously known as part of DUF156; Region: TthCsoR-like_DUF156; cd10151 1138877002623 putative homodimer interface [polypeptide binding]; other site 1138877002624 putative homotetramer interface [polypeptide binding]; other site 1138877002625 allosteric switch controlling residues; other site 1138877002626 putative metal binding site [ion binding]; other site 1138877002627 putative homodimer-homodimer interface [polypeptide binding]; other site 1138877002628 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 1138877002629 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 1138877002630 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1138877002631 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1138877002632 enoyl-CoA hydratase; Provisional; Region: PRK07827 1138877002633 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138877002634 substrate binding site [chemical binding]; other site 1138877002635 oxyanion hole (OAH) forming residues; other site 1138877002636 trimer interface [polypeptide binding]; other site 1138877002637 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138877002638 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1138877002639 active site 1138877002640 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1138877002641 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1138877002642 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1138877002643 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1138877002644 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1138877002645 carboxyltransferase (CT) interaction site; other site 1138877002646 biotinylation site [posttranslational modification]; other site 1138877002647 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1138877002648 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1138877002649 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138877002650 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138877002651 active site 1138877002652 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 1138877002653 PE family; Region: PE; pfam00934 1138877002654 PE family; Region: PE; pfam00934 1138877002655 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1138877002656 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1138877002657 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1138877002658 PE family; Region: PE; pfam00934 1138877002659 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1138877002660 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1138877002661 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1138877002662 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1138877002663 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1138877002664 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1138877002665 active site 1138877002666 phosphorylation site [posttranslational modification] 1138877002667 intermolecular recognition site; other site 1138877002668 dimerization interface [polypeptide binding]; other site 1138877002669 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1138877002670 DNA binding site [nucleotide binding] 1138877002671 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1138877002672 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1138877002673 dimerization interface [polypeptide binding]; other site 1138877002674 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1138877002675 dimer interface [polypeptide binding]; other site 1138877002676 phosphorylation site [posttranslational modification] 1138877002677 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1138877002678 ATP binding site [chemical binding]; other site 1138877002679 Mg2+ binding site [ion binding]; other site 1138877002680 G-X-G motif; other site 1138877002681 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 1138877002682 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1138877002683 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1138877002684 MPT binding site; other site 1138877002685 trimer interface [polypeptide binding]; other site 1138877002686 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1138877002687 Large-conductance mechanosensitive channel, MscL; Region: MscL; pfam01741 1138877002688 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1138877002689 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1138877002690 Walker A/P-loop; other site 1138877002691 ATP binding site [chemical binding]; other site 1138877002692 Q-loop/lid; other site 1138877002693 ABC transporter signature motif; other site 1138877002694 Walker B; other site 1138877002695 D-loop; other site 1138877002696 H-loop/switch region; other site 1138877002697 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1138877002698 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1138877002699 FtsX-like permease family; Region: FtsX; pfam02687 1138877002700 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1138877002701 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1138877002702 FtsX-like permease family; Region: FtsX; pfam02687 1138877002703 Predicted secreted hydrolase [General function prediction only]; Region: COG5621 1138877002704 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1138877002705 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1138877002706 substrate binding pocket [chemical binding]; other site 1138877002707 chain length determination region; other site 1138877002708 substrate-Mg2+ binding site; other site 1138877002709 catalytic residues [active] 1138877002710 aspartate-rich region 1; other site 1138877002711 active site lid residues [active] 1138877002712 aspartate-rich region 2; other site 1138877002713 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1138877002714 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2331 1138877002715 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 1138877002716 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1138877002717 UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210 1138877002718 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1138877002719 active site 1138877002720 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1138877002721 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1138877002722 dimer interface [polypeptide binding]; other site 1138877002723 putative functional site; other site 1138877002724 putative MPT binding site; other site 1138877002725 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1138877002726 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1138877002727 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1138877002728 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1138877002729 ligand binding site [chemical binding]; other site 1138877002730 flexible hinge region; other site 1138877002731 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1138877002732 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1138877002733 Coenzyme A binding pocket [chemical binding]; other site 1138877002734 Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145 1138877002735 arginine deiminase; Provisional; Region: PRK01388 1138877002736 Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928 1138877002737 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1138877002738 Predicted methyltransferases [General function prediction only]; Region: COG0313 1138877002739 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1138877002740 putative SAM binding site [chemical binding]; other site 1138877002741 putative homodimer interface [polypeptide binding]; other site 1138877002742 aminodeoxychorismate synthase component I; Provisional; Region: PRK05877 1138877002743 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 1138877002744 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 1138877002745 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1138877002746 active site 1138877002747 HIGH motif; other site 1138877002748 KMSKS motif; other site 1138877002749 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1138877002750 tRNA binding surface [nucleotide binding]; other site 1138877002751 anticodon binding site; other site 1138877002752 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1138877002753 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1138877002754 active site 1138877002755 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 1138877002756 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1138877002757 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1138877002758 G5 domain; Region: G5; pfam07501 1138877002759 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1138877002760 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1138877002761 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138877002762 S-adenosylmethionine binding site [chemical binding]; other site 1138877002763 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 1138877002764 Increased loss of mitochondrial DNA protein 1; Region: Ilm1; pfam10311 1138877002765 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1138877002766 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 1138877002767 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138877002768 acyl-activating enzyme (AAE) consensus motif; other site 1138877002769 AMP binding site [chemical binding]; other site 1138877002770 active site 1138877002771 CoA binding site [chemical binding]; other site 1138877002772 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1138877002773 putative active site [active] 1138877002774 catalytic residue [active] 1138877002775 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1138877002776 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 1138877002777 5S rRNA interface [nucleotide binding]; other site 1138877002778 CTC domain interface [polypeptide binding]; other site 1138877002779 L16 interface [polypeptide binding]; other site 1138877002780 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 1138877002781 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1138877002782 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 1138877002783 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1138877002784 active site 1138877002785 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 1138877002786 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1138877002787 Substrate binding site; other site 1138877002788 Mg++ binding site; other site 1138877002789 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1138877002790 active site 1138877002791 substrate binding site [chemical binding]; other site 1138877002792 CoA binding site [chemical binding]; other site 1138877002793 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138877002794 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138877002795 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1138877002796 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1138877002797 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1138877002798 ATP binding site [chemical binding]; other site 1138877002799 putative Mg++ binding site [ion binding]; other site 1138877002800 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1138877002801 nucleotide binding region [chemical binding]; other site 1138877002802 ATP-binding site [chemical binding]; other site 1138877002803 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1138877002804 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334 1138877002805 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1138877002806 homodimer interface [polypeptide binding]; other site 1138877002807 metal binding site [ion binding]; metal-binding site 1138877002808 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 1138877002809 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 1138877002810 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1138877002811 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1138877002812 enolase; Provisional; Region: eno; PRK00077 1138877002813 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1138877002814 dimer interface [polypeptide binding]; other site 1138877002815 metal binding site [ion binding]; metal-binding site 1138877002816 substrate binding pocket [chemical binding]; other site 1138877002817 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1138877002818 Septum formation initiator; Region: DivIC; pfam04977 1138877002819 Uncharacterized conserved protein [Function unknown]; Region: COG1507 1138877002820 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1138877002821 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1138877002822 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 1138877002823 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1138877002824 active site 1138877002825 phosphorylation site [posttranslational modification] 1138877002826 intermolecular recognition site; other site 1138877002827 dimerization interface [polypeptide binding]; other site 1138877002828 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1138877002829 DNA binding site [nucleotide binding] 1138877002830 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 1138877002831 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1138877002832 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1138877002833 Ligand Binding Site [chemical binding]; other site 1138877002834 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1138877002835 dimer interface [polypeptide binding]; other site 1138877002836 phosphorylation site [posttranslational modification] 1138877002837 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1138877002838 ATP binding site [chemical binding]; other site 1138877002839 Mg2+ binding site [ion binding]; other site 1138877002840 G-X-G motif; other site 1138877002841 K+-transporting ATPase, KdpA; Region: kdpA; TIGR00680 1138877002842 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 1138877002843 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1138877002844 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1138877002845 potassium-transporting ATPase subunit C; Provisional; Region: PRK14001 1138877002846 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1138877002847 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1138877002848 dimer interface [polypeptide binding]; other site 1138877002849 phosphorylation site [posttranslational modification] 1138877002850 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1138877002851 ATP binding site [chemical binding]; other site 1138877002852 Mg2+ binding site [ion binding]; other site 1138877002853 G-X-G motif; other site 1138877002854 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1138877002855 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1138877002856 active site 1138877002857 phosphorylation site [posttranslational modification] 1138877002858 intermolecular recognition site; other site 1138877002859 dimerization interface [polypeptide binding]; other site 1138877002860 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1138877002861 DNA binding site [nucleotide binding] 1138877002862 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 1138877002863 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1138877002864 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 1138877002865 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1138877002866 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1138877002867 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138877002868 PPE family; Region: PPE; pfam00823 1138877002869 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1138877002870 PE family; Region: PE; pfam00934 1138877002871 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1138877002872 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1138877002873 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1138877002874 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1138877002875 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1138877002876 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1138877002877 Predicted transcriptional regulator [Transcription]; Region: COG5340 1138877002878 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1138877002879 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 1138877002880 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1138877002881 MULE transposase domain; Region: MULE; pfam10551 1138877002882 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1138877002883 MarR family; Region: MarR_2; pfam12802 1138877002884 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138877002885 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1138877002886 NAD(P) binding site [chemical binding]; other site 1138877002887 active site 1138877002888 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 1138877002889 Helix-turn-helix domain; Region: HTH_17; pfam12728 1138877002890 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1138877002891 Domain of unknown function (DUF427); Region: DUF427; cl00998 1138877002892 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 1138877002893 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1138877002894 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1138877002895 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 1138877002896 dimer interface [polypeptide binding]; other site 1138877002897 acyl-activating enzyme (AAE) consensus motif; other site 1138877002898 putative active site [active] 1138877002899 AMP binding site [chemical binding]; other site 1138877002900 putative CoA binding site [chemical binding]; other site 1138877002901 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1138877002902 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 1138877002903 hydrophobic ligand binding site; other site 1138877002904 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 1138877002905 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1138877002906 putative active site [active] 1138877002907 putative dimer interface [polypeptide binding]; other site 1138877002908 Patatin-like phospholipase; Region: Patatin; pfam01734 1138877002909 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1138877002910 nucleophile elbow; other site 1138877002911 hypothetical protein; Provisional; Region: PRK10279 1138877002912 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 1138877002913 active site 1138877002914 nucleophile elbow; other site 1138877002915 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 1138877002916 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1138877002917 active site residue [active] 1138877002918 PE family; Region: PE; pfam00934 1138877002919 PE family; Region: PE; pfam00934 1138877002920 Predicted membrane protein [Function unknown]; Region: COG4425 1138877002921 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 1138877002922 enoyl-CoA hydratase; Provisional; Region: PRK05862 1138877002923 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138877002924 substrate binding site [chemical binding]; other site 1138877002925 oxyanion hole (OAH) forming residues; other site 1138877002926 trimer interface [polypeptide binding]; other site 1138877002927 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 1138877002928 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138877002929 substrate binding site [chemical binding]; other site 1138877002930 oxyanion hole (OAH) forming residues; other site 1138877002931 trimer interface [polypeptide binding]; other site 1138877002932 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 1138877002933 Predicted membrane protein [Function unknown]; Region: COG4760 1138877002934 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1138877002935 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1138877002936 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 1138877002937 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1138877002938 dimer interface [polypeptide binding]; other site 1138877002939 active site 1138877002940 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 1138877002941 active site 1138877002942 catalytic triad [active] 1138877002943 oxyanion hole [active] 1138877002944 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1138877002945 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1138877002946 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 1138877002947 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1138877002948 dimer interface [polypeptide binding]; other site 1138877002949 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138877002950 catalytic residue [active] 1138877002951 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 1138877002952 RDD family; Region: RDD; pfam06271 1138877002953 cystathionine gamma-synthase; Provisional; Region: PRK07811 1138877002954 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1138877002955 homodimer interface [polypeptide binding]; other site 1138877002956 substrate-cofactor binding pocket; other site 1138877002957 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138877002958 catalytic residue [active] 1138877002959 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1138877002960 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1138877002961 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1138877002962 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 1138877002963 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 1138877002964 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 1138877002965 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 1138877002966 catalytic residues [active] 1138877002967 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 1138877002968 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1138877002969 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1138877002970 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1138877002971 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1138877002972 catalytic residue [active] 1138877002973 putative FPP diphosphate binding site; other site 1138877002974 putative FPP binding hydrophobic cleft; other site 1138877002975 dimer interface [polypeptide binding]; other site 1138877002976 putative IPP diphosphate binding site; other site 1138877002977 PE family; Region: PE; pfam00934 1138877002978 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1138877002979 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 1138877002980 putative IPP diphosphate binding site; other site 1138877002981 PE family; Region: PE; pfam00934 1138877002982 Glycosyl hydrolase family 12; Region: Glyco_hydro_12; pfam01670 1138877002983 PE family; Region: PE; pfam00934 1138877002984 pantothenate kinase; Provisional; Region: PRK05439 1138877002985 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1138877002986 ATP-binding site [chemical binding]; other site 1138877002987 CoA-binding site [chemical binding]; other site 1138877002988 Mg2+-binding site [ion binding]; other site 1138877002989 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1138877002990 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1138877002991 dimer interface [polypeptide binding]; other site 1138877002992 active site 1138877002993 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1138877002994 folate binding site [chemical binding]; other site 1138877002995 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 1138877002996 dinuclear metal binding motif [ion binding]; other site 1138877002997 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 1138877002998 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 1138877002999 putative active site [active] 1138877003000 PhoH-like protein; Region: PhoH; pfam02562 1138877003001 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1138877003002 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1138877003003 NodB motif; other site 1138877003004 active site 1138877003005 catalytic site [active] 1138877003006 metal binding site [ion binding]; metal-binding site 1138877003007 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1138877003008 Class II fumarases; Region: Fumarase_classII; cd01362 1138877003009 active site 1138877003010 tetramer interface [polypeptide binding]; other site 1138877003011 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1138877003012 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1138877003013 putative active site [active] 1138877003014 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 1138877003015 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1138877003016 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1138877003017 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 1138877003018 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1138877003019 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1138877003020 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1138877003021 3beta-hydroxysteroid dehydrogenases (3b-HSD)-like, extended (e) SDRs; Region: 3b-HSD-like_SDR_e; cd05241 1138877003022 3-beta hydroxysteroid dehydrogenase/isomerase family; Region: 3Beta_HSD; pfam01073 1138877003023 putative NAD(P) binding site [chemical binding]; other site 1138877003024 active site 1138877003025 putative substrate binding site [chemical binding]; other site 1138877003026 exodeoxyribonuclease VII, small subunit; Region: xseB; TIGR01280 1138877003027 Exonuclease VII, large subunit [DNA replication, recombination, and repair]; Region: XseA; COG1570 1138877003028 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1138877003029 generic binding surface II; other site 1138877003030 generic binding surface I; other site 1138877003031 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1138877003032 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1138877003033 GTP-binding protein YchF; Reviewed; Region: PRK09601 1138877003034 YchF GTPase; Region: YchF; cd01900 1138877003035 G1 box; other site 1138877003036 GTP/Mg2+ binding site [chemical binding]; other site 1138877003037 Switch I region; other site 1138877003038 G2 box; other site 1138877003039 Switch II region; other site 1138877003040 G3 box; other site 1138877003041 G4 box; other site 1138877003042 G5 box; other site 1138877003043 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1138877003044 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 1138877003045 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: VapC; COG1487 1138877003046 putative active site [active] 1138877003047 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1138877003048 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1138877003049 cyclase homology domain; Region: CHD; cd07302 1138877003050 nucleotidyl binding site; other site 1138877003051 metal binding site [ion binding]; metal-binding site 1138877003052 dimer interface [polypeptide binding]; other site 1138877003053 glucose-6-phosphate 1-dehydrogenase; Region: zwf; TIGR00871 1138877003054 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1138877003055 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1138877003056 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1138877003057 6-phosphogluconate dehydrogenase (decarboxylating); Region: gnd_rel; TIGR00872 1138877003058 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1138877003059 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138877003060 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1138877003061 pyruvate phosphate dikinase; Provisional; Region: PRK05878 1138877003062 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1138877003063 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700 1138877003064 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1138877003065 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1138877003066 active site 1138877003067 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1138877003068 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1138877003069 non-specific DNA binding site [nucleotide binding]; other site 1138877003070 salt bridge; other site 1138877003071 sequence-specific DNA binding site [nucleotide binding]; other site 1138877003072 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 1138877003073 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1138877003074 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 1138877003075 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 1138877003076 citrate synthase; Provisional; Region: PRK14033 1138877003077 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 1138877003078 oxalacetate binding site [chemical binding]; other site 1138877003079 citrylCoA binding site [chemical binding]; other site 1138877003080 coenzyme A binding site [chemical binding]; other site 1138877003081 catalytic triad [active] 1138877003082 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 1138877003083 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1138877003084 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1138877003085 THF binding site; other site 1138877003086 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1138877003087 substrate binding site [chemical binding]; other site 1138877003088 THF binding site; other site 1138877003089 zinc-binding site [ion binding]; other site 1138877003090 PPE family; Region: PPE; pfam00823 1138877003091 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1138877003092 active site 1138877003093 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1138877003094 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138877003095 substrate binding site [chemical binding]; other site 1138877003096 oxyanion hole (OAH) forming residues; other site 1138877003097 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 1138877003098 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 1138877003099 CAAX protease self-immunity; Region: Abi; pfam02517 1138877003100 enoyl-CoA hydratase; Provisional; Region: PRK06688 1138877003101 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 1138877003102 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138877003103 trimer interface [polypeptide binding]; other site 1138877003104 enoyl-CoA hydratase; Provisional; Region: PRK06688 1138877003105 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138877003106 substrate binding site [chemical binding]; other site 1138877003107 oxyanion hole (OAH) forming residues; other site 1138877003108 trimer interface [polypeptide binding]; other site 1138877003109 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1138877003110 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1138877003111 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 1138877003112 NAD binding site [chemical binding]; other site 1138877003113 homodimer interface [polypeptide binding]; other site 1138877003114 homotetramer interface [polypeptide binding]; other site 1138877003115 active site 1138877003116 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1138877003117 MMPL family; Region: MMPL; pfam03176 1138877003118 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1138877003119 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1138877003120 active site 1138877003121 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1138877003122 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1138877003123 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1138877003124 NAD-dependent deacetylase; Provisional; Region: PRK00481 1138877003125 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 1138877003126 NAD+ binding site [chemical binding]; other site 1138877003127 substrate binding site [chemical binding]; other site 1138877003128 Zn binding site [ion binding]; other site 1138877003129 Predicted transcriptional regulators [Transcription]; Region: COG1725 1138877003130 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1138877003131 DNA-binding site [nucleotide binding]; DNA binding site 1138877003132 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138877003133 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 1138877003134 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797 1138877003135 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1138877003136 uncharacterized HhH-GPD family protein; Region: TIGR03252 1138877003137 minor groove reading motif; other site 1138877003138 helix-hairpin-helix signature motif; other site 1138877003139 mannosyltransferase; Provisional; Region: pimE; PRK13375 1138877003140 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 1138877003141 aromatic arch; other site 1138877003142 DCoH dimer interaction site [polypeptide binding]; other site 1138877003143 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 1138877003144 DCoH tetramer interaction site [polypeptide binding]; other site 1138877003145 substrate binding site [chemical binding]; other site 1138877003146 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1138877003147 active site 1138877003148 8-oxo-dGMP binding site [chemical binding]; other site 1138877003149 nudix motif; other site 1138877003150 metal binding site [ion binding]; metal-binding site 1138877003151 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 1138877003152 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1138877003153 [4Fe-4S] binding site [ion binding]; other site 1138877003154 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1138877003155 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1138877003156 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1138877003157 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1138877003158 molybdopterin cofactor binding site; other site 1138877003159 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1138877003160 nitrate reductase molybdenum cofactor assembly chaperone; Region: narJ; TIGR00684 1138877003161 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 1138877003162 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1138877003163 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1138877003164 G1 box; other site 1138877003165 putative GEF interaction site [polypeptide binding]; other site 1138877003166 GTP/Mg2+ binding site [chemical binding]; other site 1138877003167 Switch I region; other site 1138877003168 G2 box; other site 1138877003169 G3 box; other site 1138877003170 Switch II region; other site 1138877003171 G4 box; other site 1138877003172 G5 box; other site 1138877003173 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1138877003174 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1138877003175 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1138877003176 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 1138877003177 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1138877003178 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138877003179 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138877003180 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138877003181 PPE family; Region: PPE; pfam00823 1138877003182 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1138877003183 PE family; Region: PE; pfam00934 1138877003184 N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D- glucopyranoside deacetylase; Region: mycothiol_MshB; TIGR03445 1138877003185 PE family; Region: PE; pfam00934 1138877003186 FO synthase; Reviewed; Region: fbiC; PRK09234 1138877003187 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1138877003188 FeS/SAM binding site; other site 1138877003189 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1138877003190 FeS/SAM binding site; other site 1138877003191 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1138877003192 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 1138877003193 active site 1138877003194 FMN binding site [chemical binding]; other site 1138877003195 2,4-decadienoyl-CoA binding site; other site 1138877003196 catalytic residue [active] 1138877003197 4Fe-4S cluster binding site [ion binding]; other site 1138877003198 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1138877003199 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1138877003200 Predicted transcriptional regulators [Transcription]; Region: COG1695 1138877003201 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1138877003202 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 1138877003203 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 1138877003204 4Fe-4S binding domain; Region: Fer4; pfam00037 1138877003205 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 1138877003206 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1138877003207 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138877003208 homodimer interface [polypeptide binding]; other site 1138877003209 catalytic residue [active] 1138877003210 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1138877003211 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 1138877003212 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1138877003213 ATP binding site [chemical binding]; other site 1138877003214 putative Mg++ binding site [ion binding]; other site 1138877003215 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1138877003216 ATP-binding site [chemical binding]; other site 1138877003217 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1138877003218 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1138877003219 active site 1138877003220 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1138877003221 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1138877003222 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138877003223 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1138877003224 Enoylreductase; Region: PKS_ER; smart00829 1138877003225 NAD(P) binding site [chemical binding]; other site 1138877003226 KR domain; Region: KR; pfam08659 1138877003227 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1138877003228 putative NADP binding site [chemical binding]; other site 1138877003229 active site 1138877003230 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1138877003231 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1138877003232 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1138877003233 PE-PPE domain; Region: PE-PPE; pfam08237 1138877003234 acyl-CoA synthetase; Validated; Region: PRK05850 1138877003235 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1138877003236 acyl-activating enzyme (AAE) consensus motif; other site 1138877003237 active site 1138877003238 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1138877003239 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1138877003240 Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123 1138877003241 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 1138877003242 Glutamate binding site [chemical binding]; other site 1138877003243 NAD binding site [chemical binding]; other site 1138877003244 catalytic residues [active] 1138877003245 Proline dehydrogenase; Region: Pro_dh; pfam01619 1138877003246 RNA polymerase sigma factor SigI; Provisional; Region: sigI; PRK09635 1138877003247 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1138877003248 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1138877003249 DNA binding residues [nucleotide binding] 1138877003250 haloalkane dehalogenase; Provisional; Region: PRK03204 1138877003251 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1138877003252 catalytic site [active] 1138877003253 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138877003254 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 1138877003255 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1138877003256 PGAP1-like protein; Region: PGAP1; pfam07819 1138877003257 acyl-CoA synthetase; Validated; Region: PRK07787 1138877003258 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138877003259 acyl-activating enzyme (AAE) consensus motif; other site 1138877003260 AMP binding site [chemical binding]; other site 1138877003261 active site 1138877003262 CoA binding site [chemical binding]; other site 1138877003263 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1138877003264 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1138877003265 PE family; Region: PE; pfam00934 1138877003266 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138877003267 PPE family; Region: PPE; pfam00823 1138877003268 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1138877003269 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1138877003270 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1138877003271 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1138877003272 MULE transposase domain; Region: MULE; pfam10551 1138877003273 metabolite-proton symporter; Region: 2A0106; TIGR00883 1138877003274 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138877003275 putative substrate translocation pore; other site 1138877003276 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 1138877003277 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 1138877003278 putative trimer interface [polypeptide binding]; other site 1138877003279 putative CoA binding site [chemical binding]; other site 1138877003280 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 1138877003281 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 1138877003282 metal binding site [ion binding]; metal-binding site 1138877003283 putative dimer interface [polypeptide binding]; other site 1138877003284 TIGR00730 family protein; Region: TIGR00730 1138877003285 long-chain-acyl-CoA synthetase; Validated; Region: PRK08279 1138877003286 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 1138877003287 acyl-activating enzyme (AAE) consensus motif; other site 1138877003288 putative AMP binding site [chemical binding]; other site 1138877003289 putative active site [active] 1138877003290 putative CoA binding site [chemical binding]; other site 1138877003291 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1138877003292 dihydropteroate synthase; Region: DHPS; TIGR01496 1138877003293 substrate binding pocket [chemical binding]; other site 1138877003294 dimer interface [polypeptide binding]; other site 1138877003295 inhibitor binding site; inhibition site 1138877003296 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 1138877003297 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1138877003298 DivIVA domain; Region: DivI1A_domain; TIGR03544 1138877003299 DNA-3-methyladenine glycosylase I; Region: tag; TIGR00624 1138877003300 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 1138877003301 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 1138877003302 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1138877003303 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 1138877003304 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1138877003305 ligand binding site; other site 1138877003306 oligomer interface; other site 1138877003307 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1138877003308 dimer interface [polypeptide binding]; other site 1138877003309 N-terminal domain interface [polypeptide binding]; other site 1138877003310 sulfate 1 binding site; other site 1138877003311 PE family; Region: PE; pfam00934 1138877003312 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 1138877003313 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 1138877003314 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1138877003315 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 1138877003316 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1138877003317 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1138877003318 Walker A/P-loop; other site 1138877003319 ATP binding site [chemical binding]; other site 1138877003320 Q-loop/lid; other site 1138877003321 ABC transporter signature motif; other site 1138877003322 Walker B; other site 1138877003323 D-loop; other site 1138877003324 H-loop/switch region; other site 1138877003325 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1138877003326 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138877003327 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1138877003328 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138877003329 S-adenosylmethionine binding site [chemical binding]; other site 1138877003330 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647 1138877003331 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1138877003332 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1138877003333 DNA binding residues [nucleotide binding] 1138877003334 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1138877003335 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1138877003336 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1138877003337 protein binding site [polypeptide binding]; other site 1138877003338 sec-independent translocase; Provisional; Region: PRK03100 1138877003339 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1138877003340 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1138877003341 active site 1138877003342 motif I; other site 1138877003343 motif II; other site 1138877003344 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1138877003345 Predicted membrane protein [Function unknown]; Region: COG3428 1138877003346 Bacterial PH domain; Region: DUF304; pfam03703 1138877003347 Uncharacterized conserved protein [Function unknown]; Region: COG3402 1138877003348 Domain of unknown function DUF59; Region: DUF59; cl00941 1138877003349 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1138877003350 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1138877003351 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 1138877003352 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1138877003353 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1138877003354 catalytic residue [active] 1138877003355 Predicted membrane protein [Function unknown]; Region: COG4420 1138877003356 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1138877003357 MgtE intracellular N domain; Region: MgtE_N; smart00924 1138877003358 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1138877003359 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 1138877003360 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1138877003361 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1138877003362 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1138877003363 dimer interface [polypeptide binding]; other site 1138877003364 conserved gate region; other site 1138877003365 putative PBP binding loops; other site 1138877003366 ABC-ATPase subunit interface; other site 1138877003367 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1138877003368 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1138877003369 dimer interface [polypeptide binding]; other site 1138877003370 conserved gate region; other site 1138877003371 ABC-ATPase subunit interface; other site 1138877003372 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1138877003373 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1138877003374 Walker A/P-loop; other site 1138877003375 ATP binding site [chemical binding]; other site 1138877003376 Q-loop/lid; other site 1138877003377 ABC transporter signature motif; other site 1138877003378 Walker B; other site 1138877003379 D-loop; other site 1138877003380 H-loop/switch region; other site 1138877003381 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1138877003382 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 1138877003383 oligomer interface [polypeptide binding]; other site 1138877003384 metal binding site [ion binding]; metal-binding site 1138877003385 metal binding site [ion binding]; metal-binding site 1138877003386 putative Cl binding site [ion binding]; other site 1138877003387 basic sphincter; other site 1138877003388 hydrophobic gate; other site 1138877003389 periplasmic entrance; other site 1138877003390 malate dehydrogenase; Provisional; Region: PRK05442 1138877003391 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 1138877003392 NAD(P) binding site [chemical binding]; other site 1138877003393 dimer interface [polypeptide binding]; other site 1138877003394 malate binding site [chemical binding]; other site 1138877003395 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 1138877003396 PE family; Region: PE; pfam00934 1138877003397 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1138877003398 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1138877003399 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138877003400 NAD(P) binding site [chemical binding]; other site 1138877003401 active site 1138877003402 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 1138877003403 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 1138877003404 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 1138877003405 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1138877003406 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1138877003407 TPP-binding site [chemical binding]; other site 1138877003408 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1138877003409 dimer interface [polypeptide binding]; other site 1138877003410 PYR/PP interface [polypeptide binding]; other site 1138877003411 TPP binding site [chemical binding]; other site 1138877003412 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1138877003413 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138877003414 putative substrate translocation pore; other site 1138877003415 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138877003416 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 1138877003417 RNase_H superfamily; Region: RNase_H_2; pfam13482 1138877003418 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 1138877003419 Part of AAA domain; Region: AAA_19; pfam13245 1138877003420 AAA domain; Region: AAA_12; pfam13087 1138877003421 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 1138877003422 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1138877003423 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1138877003424 ATP binding site [chemical binding]; other site 1138877003425 Mg++ binding site [ion binding]; other site 1138877003426 motif III; other site 1138877003427 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1138877003428 nucleotide binding region [chemical binding]; other site 1138877003429 ATP-binding site [chemical binding]; other site 1138877003430 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 1138877003431 putative RNA binding site [nucleotide binding]; other site 1138877003432 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1138877003433 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138877003434 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138877003435 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138877003436 FAD binding domain; Region: FAD_binding_4; pfam01565 1138877003437 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 1138877003438 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138877003439 H+ Antiporter protein; Region: 2A0121; TIGR00900 1138877003440 putative substrate translocation pore; other site 1138877003441 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 1138877003442 Fe-S cluster binding site [ion binding]; other site 1138877003443 DNA binding site [nucleotide binding] 1138877003444 active site 1138877003445 hypothetical protein; Validated; Region: PRK05868 1138877003446 hypothetical protein; Provisional; Region: PRK07236 1138877003447 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1138877003448 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1138877003449 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1138877003450 HIT family signature motif; other site 1138877003451 catalytic residue [active] 1138877003452 amidase; Provisional; Region: PRK12470 1138877003453 Amidase; Region: Amidase; pfam01425 1138877003454 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1138877003455 cyclase homology domain; Region: CHD; cd07302 1138877003456 nucleotidyl binding site; other site 1138877003457 metal binding site [ion binding]; metal-binding site 1138877003458 dimer interface [polypeptide binding]; other site 1138877003459 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1138877003460 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1138877003461 active site 1138877003462 ATP binding site [chemical binding]; other site 1138877003463 substrate binding site [chemical binding]; other site 1138877003464 activation loop (A-loop); other site 1138877003465 PknH-like extracellular domain; Region: PknH_C; pfam14032 1138877003466 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 1138877003467 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 1138877003468 DNA binding site [nucleotide binding] 1138877003469 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1138877003470 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1138877003471 phosphopeptide binding site; other site 1138877003472 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 1138877003473 putative active site [active] 1138877003474 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 1138877003475 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 1138877003476 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1138877003477 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1138877003478 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1138877003479 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1138877003480 Walker A/P-loop; other site 1138877003481 ATP binding site [chemical binding]; other site 1138877003482 Q-loop/lid; other site 1138877003483 ABC transporter signature motif; other site 1138877003484 Walker B; other site 1138877003485 D-loop; other site 1138877003486 H-loop/switch region; other site 1138877003487 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1138877003488 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1138877003489 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1138877003490 Walker A/P-loop; other site 1138877003491 ATP binding site [chemical binding]; other site 1138877003492 Q-loop/lid; other site 1138877003493 ABC transporter signature motif; other site 1138877003494 Walker B; other site 1138877003495 D-loop; other site 1138877003496 H-loop/switch region; other site 1138877003497 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 1138877003498 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 1138877003499 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1138877003500 catalytic core [active] 1138877003501 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1138877003502 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1138877003503 active site 1138877003504 metal binding site [ion binding]; metal-binding site 1138877003505 DNA binding site [nucleotide binding] 1138877003506 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1138877003507 Walker A/P-loop; other site 1138877003508 ATP binding site [chemical binding]; other site 1138877003509 choline dehydrogenase; Validated; Region: PRK02106 1138877003510 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1138877003511 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1138877003512 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1138877003513 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 1138877003514 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 1138877003515 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1138877003516 Walker A/P-loop; other site 1138877003517 ATP binding site [chemical binding]; other site 1138877003518 Q-loop/lid; other site 1138877003519 ABC transporter signature motif; other site 1138877003520 Walker B; other site 1138877003521 D-loop; other site 1138877003522 H-loop/switch region; other site 1138877003523 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1138877003524 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1138877003525 Walker A/P-loop; other site 1138877003526 ATP binding site [chemical binding]; other site 1138877003527 Q-loop/lid; other site 1138877003528 ABC transporter signature motif; other site 1138877003529 Walker B; other site 1138877003530 D-loop; other site 1138877003531 H-loop/switch region; other site 1138877003532 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1138877003533 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1138877003534 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1138877003535 dimer interface [polypeptide binding]; other site 1138877003536 conserved gate region; other site 1138877003537 putative PBP binding loops; other site 1138877003538 ABC-ATPase subunit interface; other site 1138877003539 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 1138877003540 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1138877003541 dimer interface [polypeptide binding]; other site 1138877003542 conserved gate region; other site 1138877003543 putative PBP binding loops; other site 1138877003544 ABC-ATPase subunit interface; other site 1138877003545 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 1138877003546 active site clefts [active] 1138877003547 zinc binding site [ion binding]; other site 1138877003548 dimer interface [polypeptide binding]; other site 1138877003549 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1138877003550 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1138877003551 Active Sites [active] 1138877003552 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 1138877003553 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1138877003554 CysD dimerization site [polypeptide binding]; other site 1138877003555 G1 box; other site 1138877003556 putative GEF interaction site [polypeptide binding]; other site 1138877003557 GTP/Mg2+ binding site [chemical binding]; other site 1138877003558 Switch I region; other site 1138877003559 G2 box; other site 1138877003560 G3 box; other site 1138877003561 Switch II region; other site 1138877003562 G4 box; other site 1138877003563 G5 box; other site 1138877003564 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1138877003565 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 1138877003566 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1138877003567 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1138877003568 Walker A/P-loop; other site 1138877003569 ligand-binding site [chemical binding]; other site 1138877003570 ATP binding site [chemical binding]; other site 1138877003571 Rrf2 family protein; Region: rrf2_super; TIGR00738 1138877003572 Transcriptional regulator; Region: Rrf2; pfam02082 1138877003573 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1138877003574 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1138877003575 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1138877003576 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1138877003577 Putative esterase; Region: Esterase; pfam00756 1138877003578 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1138877003579 Predicted membrane protein [Function unknown]; Region: COG4325 1138877003580 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 1138877003581 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1138877003582 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 1138877003583 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1138877003584 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1138877003585 active site 1138877003586 HIGH motif; other site 1138877003587 KMSK motif region; other site 1138877003588 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1138877003589 tRNA binding surface [nucleotide binding]; other site 1138877003590 anticodon binding site; other site 1138877003591 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1138877003592 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1138877003593 active site 1138877003594 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1138877003595 substrate binding site [chemical binding]; other site 1138877003596 catalytic residues [active] 1138877003597 dimer interface [polypeptide binding]; other site 1138877003598 homoserine dehydrogenase; Provisional; Region: PRK06349 1138877003599 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1138877003600 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1138877003601 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1138877003602 threonine synthase; Reviewed; Region: PRK06721 1138877003603 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1138877003604 homodimer interface [polypeptide binding]; other site 1138877003605 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138877003606 catalytic residue [active] 1138877003607 Homoserine kinase [Amino acid transport and metabolism]; Region: ThrB; COG0083 1138877003608 transcription termination factor Rho; Provisional; Region: PRK12678 1138877003609 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1138877003610 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1138877003611 RNA binding site [nucleotide binding]; other site 1138877003612 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1138877003613 multimer interface [polypeptide binding]; other site 1138877003614 Walker A motif; other site 1138877003615 ATP binding site [chemical binding]; other site 1138877003616 Walker B motif; other site 1138877003617 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1138877003618 peptide chain release factor 1; Region: prfA; TIGR00019 1138877003619 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1138877003620 RF-1 domain; Region: RF-1; pfam00472 1138877003621 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1138877003622 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138877003623 S-adenosylmethionine binding site [chemical binding]; other site 1138877003624 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1138877003625 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1138877003626 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1138877003627 Mg++ binding site [ion binding]; other site 1138877003628 putative catalytic motif [active] 1138877003629 substrate binding site [chemical binding]; other site 1138877003630 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1138877003631 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1138877003632 F0F1 ATP synthase subunit C; Validated; Region: PRK05880 1138877003633 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1138877003634 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1138877003635 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13428 1138877003636 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1138877003637 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 1138877003638 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1138877003639 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1138877003640 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1138877003641 Walker A motif; other site 1138877003642 ATP binding site [chemical binding]; other site 1138877003643 Walker B motif; other site 1138877003644 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1138877003645 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1138877003646 core domain interface [polypeptide binding]; other site 1138877003647 delta subunit interface [polypeptide binding]; other site 1138877003648 epsilon subunit interface [polypeptide binding]; other site 1138877003649 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1138877003650 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1138877003651 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1138877003652 alpha subunit interaction interface [polypeptide binding]; other site 1138877003653 Walker A motif; other site 1138877003654 ATP binding site [chemical binding]; other site 1138877003655 Walker B motif; other site 1138877003656 inhibitor binding site; inhibition site 1138877003657 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1138877003658 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1138877003659 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1138877003660 gamma subunit interface [polypeptide binding]; other site 1138877003661 epsilon subunit interface [polypeptide binding]; other site 1138877003662 LBP interface [polypeptide binding]; other site 1138877003663 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 1138877003664 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1138877003665 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1138877003666 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 1138877003667 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1138877003668 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1138877003669 hinge; other site 1138877003670 active site 1138877003671 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 1138877003672 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1138877003673 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1138877003674 DNA binding site [nucleotide binding] 1138877003675 active site 1138877003676 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 1138877003677 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1138877003678 AlkA N-terminal domain; Region: AlkA_N; pfam06029 1138877003679 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 1138877003680 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1138877003681 minor groove reading motif; other site 1138877003682 helix-hairpin-helix signature motif; other site 1138877003683 substrate binding pocket [chemical binding]; other site 1138877003684 active site 1138877003685 HAMP domain; Region: HAMP; pfam00672 1138877003686 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1138877003687 cyclase homology domain; Region: CHD; cd07302 1138877003688 nucleotidyl binding site; other site 1138877003689 metal binding site [ion binding]; metal-binding site 1138877003690 dimer interface [polypeptide binding]; other site 1138877003691 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1138877003692 dimerization interface [polypeptide binding]; other site 1138877003693 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1138877003694 cyclase homology domain; Region: CHD; cd07302 1138877003695 nucleotidyl binding site; other site 1138877003696 metal binding site [ion binding]; metal-binding site 1138877003697 dimer interface [polypeptide binding]; other site 1138877003698 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1138877003699 dimerization interface [polypeptide binding]; other site 1138877003700 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1138877003701 cyclase homology domain; Region: CHD; cd07302 1138877003702 nucleotidyl binding site; other site 1138877003703 metal binding site [ion binding]; metal-binding site 1138877003704 dimer interface [polypeptide binding]; other site 1138877003705 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1138877003706 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1138877003707 dimerization interface [polypeptide binding]; other site 1138877003708 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1138877003709 cyclase homology domain; Region: CHD; cd07302 1138877003710 nucleotidyl binding site; other site 1138877003711 metal binding site [ion binding]; metal-binding site 1138877003712 dimer interface [polypeptide binding]; other site 1138877003713 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 1138877003714 hypothetical protein; Provisional; Region: PRK03298 1138877003715 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1138877003716 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 1138877003717 dimer interface [polypeptide binding]; other site 1138877003718 substrate binding site [chemical binding]; other site 1138877003719 metal binding site [ion binding]; metal-binding site 1138877003720 putative acyltransferase; Provisional; Region: PRK05790 1138877003721 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1138877003722 dimer interface [polypeptide binding]; other site 1138877003723 active site 1138877003724 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 1138877003725 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 1138877003726 PE family; Region: PE; pfam00934 1138877003727 glycogen branching enzyme; Provisional; Region: PRK05402 1138877003728 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1138877003729 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1138877003730 active site 1138877003731 catalytic site [active] 1138877003732 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1138877003733 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 1138877003734 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 1138877003735 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1138877003736 active site 1138877003737 homodimer interface [polypeptide binding]; other site 1138877003738 catalytic site [active] 1138877003739 acceptor binding site [chemical binding]; other site 1138877003740 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 1138877003741 putative homodimer interface [polypeptide binding]; other site 1138877003742 putative active site pocket [active] 1138877003743 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 1138877003744 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1138877003745 DEAD/DEAH box helicase; Region: DEAD; pfam00270 1138877003746 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1138877003747 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1138877003748 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1138877003749 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1138877003750 active site 1138877003751 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 1138877003752 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 1138877003753 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 1138877003754 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 1138877003755 putative active site pocket [active] 1138877003756 cleavage site 1138877003757 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 1138877003758 MPN+ (JAMM) motif; other site 1138877003759 Zinc-binding site [ion binding]; other site 1138877003760 Ubiquitin-like proteins; Region: UBQ; cl00155 1138877003761 charged pocket; other site 1138877003762 hydrophobic patch; other site 1138877003763 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1138877003764 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1138877003765 dimer interface [polypeptide binding]; other site 1138877003766 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138877003767 catalytic residue [active] 1138877003768 Rhomboid family; Region: Rhomboid; pfam01694 1138877003769 glutamate racemase; Provisional; Region: PRK00865 1138877003770 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1138877003771 ribonuclease PH; Reviewed; Region: rph; PRK00173 1138877003772 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1138877003773 hexamer interface [polypeptide binding]; other site 1138877003774 active site 1138877003775 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1138877003776 active site 1138877003777 dimerization interface [polypeptide binding]; other site 1138877003778 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 1138877003779 Glucitol operon activator [Transcription]; Region: GutM; COG4578 1138877003780 acyl carrier protein; Validated; Region: PRK05883 1138877003781 long-chain-fatty-acid--[acyl-carrier-protein] ligase; Validated; Region: PRK05851 1138877003782 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1138877003783 acyl-activating enzyme (AAE) consensus motif; other site 1138877003784 active site 1138877003785 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138877003786 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138877003787 active site 1138877003788 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1138877003789 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 1138877003790 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1138877003791 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1138877003792 FAD binding pocket [chemical binding]; other site 1138877003793 FAD binding motif [chemical binding]; other site 1138877003794 phosphate binding motif [ion binding]; other site 1138877003795 NAD binding pocket [chemical binding]; other site 1138877003796 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1138877003797 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1138877003798 Walker A/P-loop; other site 1138877003799 ATP binding site [chemical binding]; other site 1138877003800 Q-loop/lid; other site 1138877003801 ABC transporter signature motif; other site 1138877003802 Walker B; other site 1138877003803 D-loop; other site 1138877003804 H-loop/switch region; other site 1138877003805 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1138877003806 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1138877003807 Walker A/P-loop; other site 1138877003808 ATP binding site [chemical binding]; other site 1138877003809 Q-loop/lid; other site 1138877003810 ABC transporter signature motif; other site 1138877003811 Walker B; other site 1138877003812 D-loop; other site 1138877003813 H-loop/switch region; other site 1138877003814 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1138877003815 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138877003816 NAD(P) binding site [chemical binding]; other site 1138877003817 active site 1138877003818 tetracycline repressor protein TetR; Provisional; Region: PRK13756 1138877003819 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138877003820 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1138877003821 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1138877003822 GAF domain; Region: GAF; pfam01590 1138877003823 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1138877003824 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1138877003825 metal binding site [ion binding]; metal-binding site 1138877003826 active site 1138877003827 I-site; other site 1138877003828 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1138877003829 hypothetical protein; Provisional; Region: PRK07877 1138877003830 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 1138877003831 ATP binding site [chemical binding]; other site 1138877003832 substrate interface [chemical binding]; other site 1138877003833 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1138877003834 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1138877003835 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1138877003836 cyclase homology domain; Region: CHD; cd07302 1138877003837 nucleotidyl binding site; other site 1138877003838 dimer interface [polypeptide binding]; other site 1138877003839 metal binding site [ion binding]; metal-binding site 1138877003840 Predicted ATPase [General function prediction only]; Region: COG3903 1138877003841 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1138877003842 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1138877003843 DNA binding residues [nucleotide binding] 1138877003844 dimerization interface [polypeptide binding]; other site 1138877003845 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1138877003846 cyclase homology domain; Region: CHD; cd07302 1138877003847 probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841 1138877003848 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1138877003849 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138877003850 PPE family; Region: PPE; pfam00823 1138877003851 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1138877003852 PAS fold; Region: PAS_4; pfam08448 1138877003853 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1138877003854 putative active site [active] 1138877003855 heme pocket [chemical binding]; other site 1138877003856 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1138877003857 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1138877003858 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1138877003859 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1138877003860 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1138877003861 anti sigma factor interaction site; other site 1138877003862 regulatory phosphorylation site [posttranslational modification]; other site 1138877003863 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1138877003864 anti sigma factor interaction site; other site 1138877003865 regulatory phosphorylation site [posttranslational modification]; other site 1138877003866 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1138877003867 synthetase active site [active] 1138877003868 NTP binding site [chemical binding]; other site 1138877003869 metal binding site [ion binding]; metal-binding site 1138877003870 Beta-lactamase; Region: Beta-lactamase; pfam00144 1138877003871 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1138877003872 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 1138877003873 Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; pfam00173 1138877003874 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1138877003875 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 1138877003876 putative di-iron ligands [ion binding]; other site 1138877003877 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 1138877003878 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 1138877003879 malonyl-CoA binding site [chemical binding]; other site 1138877003880 dimer interface [polypeptide binding]; other site 1138877003881 active site 1138877003882 product binding site; other site 1138877003883 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 1138877003884 uncharacterized domain; Region: TIGR00702 1138877003885 YcaO-like family; Region: YcaO; pfam02624 1138877003886 Uncharacterized conserved protein [Function unknown]; Region: COG3482 1138877003887 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138877003888 S-adenosylmethionine binding site [chemical binding]; other site 1138877003889 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1138877003890 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1138877003891 active site 1138877003892 bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; Provisional; Region: PRK05205 1138877003893 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1138877003894 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1138877003895 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1138877003896 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1138877003897 dihydroorotase; Validated; Region: pyrC; PRK09357 1138877003898 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1138877003899 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1138877003900 active site 1138877003901 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1138877003902 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1138877003903 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1138877003904 catalytic site [active] 1138877003905 subunit interface [polypeptide binding]; other site 1138877003906 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1138877003907 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1138877003908 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1138877003909 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1138877003910 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1138877003911 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1138877003912 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1138877003913 IMP binding site; other site 1138877003914 dimer interface [polypeptide binding]; other site 1138877003915 interdomain contacts; other site 1138877003916 partial ornithine binding site; other site 1138877003917 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1138877003918 active site 1138877003919 dimer interface [polypeptide binding]; other site 1138877003920 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138877003921 PPE family; Region: PPE; pfam00823 1138877003922 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1138877003923 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1138877003924 catalytic site [active] 1138877003925 G-X2-G-X-G-K; other site 1138877003926 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 1138877003927 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1138877003928 Flavoprotein; Region: Flavoprotein; pfam02441 1138877003929 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1138877003930 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1138877003931 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1138877003932 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1138877003933 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1138877003934 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1138877003935 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1138877003936 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138877003937 Cytochrome P450; Region: p450; cl12078 1138877003938 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1138877003939 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1138877003940 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1138877003941 PE family; Region: PE; pfam00934 1138877003942 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1138877003943 oligomeric interface; other site 1138877003944 putative active site [active] 1138877003945 homodimer interface [polypeptide binding]; other site 1138877003946 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1138877003947 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1138877003948 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1138877003949 substrate binding pocket [chemical binding]; other site 1138877003950 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1138877003951 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1138877003952 substrate binding pocket [chemical binding]; other site 1138877003953 Predicted membrane protein [Function unknown]; Region: COG3714 1138877003954 primosome assembly protein PriA; Provisional; Region: PRK14873 1138877003955 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138877003956 S-adenosylmethionine binding site [chemical binding]; other site 1138877003957 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1138877003958 MarR family; Region: MarR; pfam01047 1138877003959 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138877003960 S-adenosylmethionine binding site [chemical binding]; other site 1138877003961 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1138877003962 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1138877003963 putative active site [active] 1138877003964 substrate binding site [chemical binding]; other site 1138877003965 putative cosubstrate binding site; other site 1138877003966 catalytic site [active] 1138877003967 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1138877003968 substrate binding site [chemical binding]; other site 1138877003969 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 1138877003970 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 1138877003971 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 1138877003972 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1138877003973 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 1138877003974 substrate binding site [chemical binding]; other site 1138877003975 hexamer interface [polypeptide binding]; other site 1138877003976 metal binding site [ion binding]; metal-binding site 1138877003977 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1138877003978 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1138877003979 catalytic motif [active] 1138877003980 Zn binding site [ion binding]; other site 1138877003981 RibD C-terminal domain; Region: RibD_C; pfam01872 1138877003982 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1138877003983 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138877003984 putative substrate translocation pore; other site 1138877003985 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 1138877003986 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1138877003987 Lumazine binding domain; Region: Lum_binding; pfam00677 1138877003988 Lumazine binding domain; Region: Lum_binding; pfam00677 1138877003989 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 1138877003990 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1138877003991 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1138877003992 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 1138877003993 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1138877003994 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1138877003995 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1138877003996 dimerization interface [polypeptide binding]; other site 1138877003997 active site 1138877003998 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1138877003999 homopentamer interface [polypeptide binding]; other site 1138877004000 active site 1138877004001 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1138877004002 PknH-like extracellular domain; Region: PknH_C; pfam14032 1138877004003 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1138877004004 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1138877004005 putative sugar binding sites [chemical binding]; other site 1138877004006 Q-X-W motif; other site 1138877004007 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1138877004008 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1138877004009 GIY-YIG motif/motif A; other site 1138877004010 active site 1138877004011 catalytic site [active] 1138877004012 putative DNA binding site [nucleotide binding]; other site 1138877004013 metal binding site [ion binding]; metal-binding site 1138877004014 UvrB/uvrC motif; Region: UVR; pfam02151 1138877004015 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1138877004016 Helix-hairpin-helix motif; Region: HHH; pfam00633 1138877004017 P-loop ATPase protein family; Region: ATP_bind_2; pfam03668 1138877004018 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1138877004019 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1138877004020 phosphate binding site [ion binding]; other site 1138877004021 putative substrate binding pocket [chemical binding]; other site 1138877004022 dimer interface [polypeptide binding]; other site 1138877004023 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1138877004024 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1138877004025 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1138877004026 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1138877004027 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1138877004028 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1138877004029 acyl-CoA synthetase; Provisional; Region: PRK13382 1138877004030 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1138877004031 acyl-activating enzyme (AAE) consensus motif; other site 1138877004032 putative AMP binding site [chemical binding]; other site 1138877004033 putative active site [active] 1138877004034 putative CoA binding site [chemical binding]; other site 1138877004035 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1138877004036 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 1138877004037 putative acyl-acceptor binding pocket; other site 1138877004038 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1138877004039 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1138877004040 PE family; Region: PE; pfam00934 1138877004041 PE-PPE domain; Region: PE-PPE; pfam08237 1138877004042 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 1138877004043 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1138877004044 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1138877004045 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 1138877004046 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1138877004047 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1138877004048 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1138877004049 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1138877004050 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1138877004051 Phosphoglycerate kinase; Region: PGK; pfam00162 1138877004052 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1138877004053 substrate binding site [chemical binding]; other site 1138877004054 hinge regions; other site 1138877004055 ADP binding site [chemical binding]; other site 1138877004056 catalytic site [active] 1138877004057 triosephosphate isomerase; Provisional; Region: PRK14567 1138877004058 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1138877004059 substrate binding site [chemical binding]; other site 1138877004060 dimer interface [polypeptide binding]; other site 1138877004061 catalytic triad [active] 1138877004062 SnoaL-like domain; Region: SnoaL_2; pfam12680 1138877004063 Preprotein translocase SecG subunit; Region: SecG; cl09123 1138877004064 PE family; Region: PE; pfam00934 1138877004065 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 1138877004066 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 1138877004067 molybdopterin cofactor binding site [chemical binding]; other site 1138877004068 substrate binding site [chemical binding]; other site 1138877004069 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 1138877004070 molybdopterin cofactor binding site; other site 1138877004071 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1138877004072 hydrophobic ligand binding site; other site 1138877004073 Proteins of 100 residues with WXG; Region: WXG100; cl02005 1138877004074 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1138877004075 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 1138877004076 putative active site [active] 1138877004077 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 1138877004078 Glucose-6-P dehydrogenase subunit [Carbohydrate transport and metabolism]; Region: COG3429 1138877004079 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1138877004080 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1138877004081 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1138877004082 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 1138877004083 putative active site [active] 1138877004084 transaldolase; Provisional; Region: PRK03903 1138877004085 catalytic residue [active] 1138877004086 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1138877004087 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1138877004088 TPP-binding site [chemical binding]; other site 1138877004089 dimer interface [polypeptide binding]; other site 1138877004090 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1138877004091 PYR/PP interface [polypeptide binding]; other site 1138877004092 dimer interface [polypeptide binding]; other site 1138877004093 TPP binding site [chemical binding]; other site 1138877004094 PE family; Region: PE; pfam00934 1138877004095 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1138877004096 UbiA prenyltransferase family; Region: UbiA; pfam01040 1138877004097 PE family; Region: PE; pfam00934 1138877004098 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1138877004099 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1138877004100 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 1138877004101 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 1138877004102 NADP binding site [chemical binding]; other site 1138877004103 dimer interface [polypeptide binding]; other site 1138877004104 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1138877004105 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1138877004106 ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025 1138877004107 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1138877004108 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1138877004109 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1138877004110 Walker A/P-loop; other site 1138877004111 ATP binding site [chemical binding]; other site 1138877004112 Q-loop/lid; other site 1138877004113 ABC transporter signature motif; other site 1138877004114 Walker B; other site 1138877004115 D-loop; other site 1138877004116 H-loop/switch region; other site 1138877004117 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 1138877004118 Predicted transcriptional regulator [Transcription]; Region: COG2345 1138877004119 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1138877004120 putative DNA binding site [nucleotide binding]; other site 1138877004121 putative Zn2+ binding site [ion binding]; other site 1138877004122 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1138877004123 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1138877004124 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1138877004125 protein-splicing catalytic site; other site 1138877004126 thioester formation/cholesterol transfer; other site 1138877004127 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 1138877004128 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 1138877004129 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1138877004130 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1138877004131 FeS assembly protein SufD; Region: sufD; TIGR01981 1138877004132 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1138877004133 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1138877004134 Walker A/P-loop; other site 1138877004135 ATP binding site [chemical binding]; other site 1138877004136 Q-loop/lid; other site 1138877004137 ABC transporter signature motif; other site 1138877004138 Walker B; other site 1138877004139 D-loop; other site 1138877004140 H-loop/switch region; other site 1138877004141 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1138877004142 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1138877004143 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1138877004144 catalytic residue [active] 1138877004145 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1138877004146 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1138877004147 trimerization site [polypeptide binding]; other site 1138877004148 active site 1138877004149 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1138877004150 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1138877004151 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1138877004152 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138877004153 active site 1138877004154 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1138877004155 PE family; Region: PE; pfam00934 1138877004156 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 1138877004157 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1138877004158 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1138877004159 catalytic residues [active] 1138877004160 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1138877004161 catalytic residues [active] 1138877004162 enoyl-CoA hydratase; Provisional; Region: PRK05864 1138877004163 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138877004164 substrate binding site [chemical binding]; other site 1138877004165 oxyanion hole (OAH) forming residues; other site 1138877004166 trimer interface [polypeptide binding]; other site 1138877004167 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1138877004168 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1138877004169 Walker A/P-loop; other site 1138877004170 ATP binding site [chemical binding]; other site 1138877004171 Q-loop/lid; other site 1138877004172 ABC transporter signature motif; other site 1138877004173 Walker B; other site 1138877004174 D-loop; other site 1138877004175 H-loop/switch region; other site 1138877004176 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1138877004177 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138877004178 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138877004179 aconitate hydratase; Validated; Region: PRK09277 1138877004180 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1138877004181 substrate binding site [chemical binding]; other site 1138877004182 ligand binding site [chemical binding]; other site 1138877004183 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1138877004184 substrate binding site [chemical binding]; other site 1138877004185 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1138877004186 NlpC/P60 family; Region: NLPC_P60; pfam00877 1138877004187 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1138877004188 NlpC/P60 family; Region: NLPC_P60; pfam00877 1138877004189 MoxR-like ATPases [General function prediction only]; Region: COG0714 1138877004190 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138877004191 Walker A motif; other site 1138877004192 ATP binding site [chemical binding]; other site 1138877004193 Walker B motif; other site 1138877004194 arginine finger; other site 1138877004195 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1138877004196 Protein of unknown function DUF58; Region: DUF58; pfam01882 1138877004197 hypothetical protein; Provisional; Region: PRK13685 1138877004198 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1138877004199 metal ion-dependent adhesion site (MIDAS); other site 1138877004200 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1138877004201 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1138877004202 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1138877004203 NAD(P) binding site [chemical binding]; other site 1138877004204 homotetramer interface [polypeptide binding]; other site 1138877004205 homodimer interface [polypeptide binding]; other site 1138877004206 active site 1138877004207 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 1138877004208 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1138877004209 NAD binding site [chemical binding]; other site 1138877004210 homotetramer interface [polypeptide binding]; other site 1138877004211 homodimer interface [polypeptide binding]; other site 1138877004212 substrate binding site [chemical binding]; other site 1138877004213 active site 1138877004214 ferrochelatase; Reviewed; Region: hemH; PRK00035 1138877004215 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1138877004216 C-terminal domain interface [polypeptide binding]; other site 1138877004217 active site 1138877004218 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1138877004219 active site 1138877004220 N-terminal domain interface [polypeptide binding]; other site 1138877004221 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 1138877004222 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1138877004223 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1138877004224 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 1138877004225 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1138877004226 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1138877004227 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 1138877004228 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 1138877004229 heterodimer interface [polypeptide binding]; other site 1138877004230 substrate interaction site [chemical binding]; other site 1138877004231 Methylmalonyl-CoA mutase, C-terminal domain/subunit (cobalamin-binding) [Lipid metabolism]; Region: Sbm; COG2185 1138877004232 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 1138877004233 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 1138877004234 active site 1138877004235 substrate binding site [chemical binding]; other site 1138877004236 coenzyme B12 binding site [chemical binding]; other site 1138877004237 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 1138877004238 B12 binding site [chemical binding]; other site 1138877004239 cobalt ligand [ion binding]; other site 1138877004240 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 1138877004241 membrane ATPase/protein kinase; Provisional; Region: PRK09435 1138877004242 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 1138877004243 Walker A; other site 1138877004244 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1138877004245 Beta-lactamase; Region: Beta-lactamase; pfam00144 1138877004246 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1138877004247 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138877004248 S-adenosylmethionine binding site [chemical binding]; other site 1138877004249 Uncharacterized conserved protein [Function unknown]; Region: COG3360 1138877004250 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1138877004251 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1138877004252 Ligand binding site; other site 1138877004253 Putative Catalytic site; other site 1138877004254 DXD motif; other site 1138877004255 Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5285 1138877004256 Glycosyl hydrolase families 32 and 68, which for the clan GH-J; Region: GH_J; cd08979 1138877004257 active site 1138877004258 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1138877004259 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1138877004260 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1138877004261 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1138877004262 inhibitor-cofactor binding pocket; inhibition site 1138877004263 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138877004264 catalytic residue [active] 1138877004265 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 1138877004266 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 1138877004267 putative trimer interface [polypeptide binding]; other site 1138877004268 putative CoA binding site [chemical binding]; other site 1138877004269 Methyltransferase domain; Region: Methyltransf_12; pfam08242 1138877004270 S-adenosylmethionine binding site [chemical binding]; other site 1138877004271 WbqC-like protein family; Region: WbqC; pfam08889 1138877004272 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 1138877004273 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138877004274 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138877004275 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1138877004276 Methyltransferase domain; Region: Methyltransf_12; pfam08242 1138877004277 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 1138877004278 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 1138877004279 NADP-binding site; other site 1138877004280 homotetramer interface [polypeptide binding]; other site 1138877004281 substrate binding site [chemical binding]; other site 1138877004282 homodimer interface [polypeptide binding]; other site 1138877004283 active site 1138877004284 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 1138877004285 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 1138877004286 NADP binding site [chemical binding]; other site 1138877004287 active site 1138877004288 putative substrate binding site [chemical binding]; other site 1138877004289 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 1138877004290 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 1138877004291 metal-binding site 1138877004292 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138877004293 S-adenosylmethionine binding site [chemical binding]; other site 1138877004294 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1138877004295 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1138877004296 active site 1138877004297 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 1138877004298 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1138877004299 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1138877004300 active site 1138877004301 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 1138877004302 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1138877004303 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1138877004304 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1138877004305 active site 1138877004306 acyl-CoA synthetase; Validated; Region: PRK05850 1138877004307 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1138877004308 acyl-activating enzyme (AAE) consensus motif; other site 1138877004309 active site 1138877004310 Transport protein; Region: actII; TIGR00833 1138877004311 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1138877004312 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138877004313 S-adenosylmethionine binding site [chemical binding]; other site 1138877004314 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1138877004315 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1138877004316 homodimer interface [polypeptide binding]; other site 1138877004317 active site 1138877004318 TDP-binding site; other site 1138877004319 acceptor substrate-binding pocket; other site 1138877004320 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1138877004321 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1138877004322 Probable Catalytic site; other site 1138877004323 metal-binding site 1138877004324 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1138877004325 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1138877004326 homodimer interface [polypeptide binding]; other site 1138877004327 active site 1138877004328 TDP-binding site; other site 1138877004329 acceptor substrate-binding pocket; other site 1138877004330 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1138877004331 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1138877004332 active site 1138877004333 Acyl transferase domain; Region: Acyl_transf_1; pfam00698 1138877004334 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1138877004335 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138877004336 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1138877004337 Enoylreductase; Region: PKS_ER; smart00829 1138877004338 NAD(P) binding site [chemical binding]; other site 1138877004339 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1138877004340 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1138877004341 putative NADP binding site [chemical binding]; other site 1138877004342 active site 1138877004343 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1138877004344 acyl-CoA synthetase; Validated; Region: PRK05850 1138877004345 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1138877004346 acyl-activating enzyme (AAE) consensus motif; other site 1138877004347 active site 1138877004348 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1138877004349 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1138877004350 NAD(P) binding site [chemical binding]; other site 1138877004351 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1138877004352 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1138877004353 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1138877004354 CoenzymeA binding site [chemical binding]; other site 1138877004355 subunit interaction site [polypeptide binding]; other site 1138877004356 PHB binding site; other site 1138877004357 Nitronate monooxygenase; Region: NMO; pfam03060 1138877004358 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1138877004359 FMN binding site [chemical binding]; other site 1138877004360 substrate binding site [chemical binding]; other site 1138877004361 putative catalytic residue [active] 1138877004362 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138877004363 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 1138877004364 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1138877004365 HIGH motif; other site 1138877004366 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1138877004367 active site 1138877004368 KMSKS motif; other site 1138877004369 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 1138877004370 tRNA binding surface [nucleotide binding]; other site 1138877004371 anticodon binding site; other site 1138877004372 DNA polymerase IV; Provisional; Region: PRK03348 1138877004373 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1138877004374 active site 1138877004375 DNA binding site [nucleotide binding] 1138877004376 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1138877004377 active site 1138877004378 homodimer interface [polypeptide binding]; other site 1138877004379 homotetramer interface [polypeptide binding]; other site 1138877004380 lipoprotein signal peptidase; Provisional; Region: PRK14764 1138877004381 lipoprotein signal peptidase; Provisional; Region: PRK14787 1138877004382 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1138877004383 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1138877004384 active site 1138877004385 Uncharacterized protein conserved in bacteria, putative lipoprotein [Function unknown]; Region: LprI; COG4461 1138877004386 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 1138877004387 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 1138877004388 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1138877004389 apolar tunnel; other site 1138877004390 heme binding site [chemical binding]; other site 1138877004391 dimerization interface [polypeptide binding]; other site 1138877004392 short chain dehydrogenase; Provisional; Region: PRK05866 1138877004393 classical (c) SDRs; Region: SDR_c; cd05233 1138877004394 NAD(P) binding site [chemical binding]; other site 1138877004395 active site 1138877004396 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1138877004397 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138877004398 NAD(P) binding site [chemical binding]; other site 1138877004399 active site 1138877004400 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1138877004401 hydrophobic ligand binding site; other site 1138877004402 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1138877004403 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 1138877004404 active site 1138877004405 PHP Thumb interface [polypeptide binding]; other site 1138877004406 metal binding site [ion binding]; metal-binding site 1138877004407 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1138877004408 generic binding surface II; other site 1138877004409 generic binding surface I; other site 1138877004410 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138877004411 PPE family; Region: PPE; pfam00823 1138877004412 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1138877004413 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1138877004414 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138877004415 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1138877004416 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1138877004417 acyl-activating enzyme (AAE) consensus motif; other site 1138877004418 putative AMP binding site [chemical binding]; other site 1138877004419 putative active site [active] 1138877004420 putative CoA binding site [chemical binding]; other site 1138877004421 glycerol-3-phosphate acyltransferase; Reviewed; Region: PRK11915 1138877004422 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 1138877004423 putative acyl-acceptor binding pocket; other site 1138877004424 fumarate reductase, flavoprotein subunit; Region: fum_red_Fp; TIGR01176 1138877004425 L-aspartate oxidase; Provisional; Region: PRK06175 1138877004426 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1138877004427 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 1138877004428 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1138877004429 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 1138877004430 D-subunit interface [polypeptide binding]; other site 1138877004431 Iron-sulfur protein interface; other site 1138877004432 proximal quinone binding site [chemical binding]; other site 1138877004433 distal quinone binding site [chemical binding]; other site 1138877004434 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 1138877004435 Iron-sulfur protein interface; other site 1138877004436 proximal quinone binding site [chemical binding]; other site 1138877004437 C-subunit interface; other site 1138877004438 distal quinone binding site; other site 1138877004439 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138877004440 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138877004441 MMPL family; Region: MMPL; pfam03176 1138877004442 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1138877004443 threonine dehydratase; Validated; Region: PRK08639 1138877004444 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1138877004445 tetramer interface [polypeptide binding]; other site 1138877004446 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138877004447 catalytic residue [active] 1138877004448 C-terminal regulatory domain of Threonine dehydratase; Region: Thr_dehydrat_C; pfam00585 1138877004449 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 1138877004450 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 1138877004451 putative active site [active] 1138877004452 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 1138877004453 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 1138877004454 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 1138877004455 catalytic site [active] 1138877004456 active site 1138877004457 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1138877004458 malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401 1138877004459 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 1138877004460 active site 1138877004461 catalytic site [active] 1138877004462 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1138877004463 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1138877004464 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1138877004465 active site 1138877004466 catalytic site [active] 1138877004467 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1138877004468 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1138877004469 NlpC/P60 family; Region: NLPC_P60; pfam00877 1138877004470 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 1138877004471 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1138877004472 inhibitor-cofactor binding pocket; inhibition site 1138877004473 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138877004474 catalytic residue [active] 1138877004475 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 1138877004476 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 1138877004477 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1138877004478 catalytic residue [active] 1138877004479 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1138877004480 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 1138877004481 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1138877004482 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1138877004483 active site 1138877004484 biotin synthase; Validated; Region: PRK06256 1138877004485 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1138877004486 FeS/SAM binding site; other site 1138877004487 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1138877004488 Protein of unknown function (DUF2567); Region: DUF2567; pfam10821 1138877004489 Secretory lipase; Region: LIP; pfam03583 1138877004490 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 1138877004491 nudix motif; other site 1138877004492 quinolinate synthetase; Provisional; Region: PRK09375 1138877004493 L-aspartate oxidase; Provisional; Region: PRK07804 1138877004494 L-aspartate oxidase; Provisional; Region: PRK06175 1138877004495 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1138877004496 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 1138877004497 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1138877004498 dimerization interface [polypeptide binding]; other site 1138877004499 active site 1138877004500 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138877004501 S-adenosylmethionine binding site [chemical binding]; other site 1138877004502 deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026 1138877004503 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 1138877004504 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1138877004505 NAD binding site [chemical binding]; other site 1138877004506 dimerization interface [polypeptide binding]; other site 1138877004507 product binding site; other site 1138877004508 substrate binding site [chemical binding]; other site 1138877004509 zinc binding site [ion binding]; other site 1138877004510 catalytic residues [active] 1138877004511 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 1138877004512 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1138877004513 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138877004514 homodimer interface [polypeptide binding]; other site 1138877004515 catalytic residue [active] 1138877004516 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1138877004517 4-fold oligomerization interface [polypeptide binding]; other site 1138877004518 putative active site pocket [active] 1138877004519 metal binding residues [ion binding]; metal-binding site 1138877004520 3-fold/trimer interface [polypeptide binding]; other site 1138877004521 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 1138877004522 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1138877004523 putative active site [active] 1138877004524 oxyanion strand; other site 1138877004525 catalytic triad [active] 1138877004526 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1138877004527 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1138877004528 catalytic residues [active] 1138877004529 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1138877004530 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1138877004531 active site 1138877004532 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1138877004533 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1138877004534 substrate binding site [chemical binding]; other site 1138877004535 glutamase interaction surface [polypeptide binding]; other site 1138877004536 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 1138877004537 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 1138877004538 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1138877004539 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1138877004540 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1138877004541 catalytic triad [active] 1138877004542 anthranilate synthase component I; Provisional; Region: PRK13571 1138877004543 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1138877004544 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1138877004545 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534 1138877004546 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1138877004547 active site 1138877004548 ribulose/triose binding site [chemical binding]; other site 1138877004549 phosphate binding site [ion binding]; other site 1138877004550 substrate (anthranilate) binding pocket [chemical binding]; other site 1138877004551 product (indole) binding pocket [chemical binding]; other site 1138877004552 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1138877004553 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1138877004554 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138877004555 catalytic residue [active] 1138877004556 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1138877004557 substrate binding site [chemical binding]; other site 1138877004558 active site 1138877004559 catalytic residues [active] 1138877004560 heterodimer interface [polypeptide binding]; other site 1138877004561 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK13108 1138877004562 Prolipoprotein diacylglyceryltransferase [Cell envelope biogenesis, outer membrane]; Region: Lgt; COG0682 1138877004563 TM2 domain; Region: TM2; pfam05154 1138877004564 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 1138877004565 pyruvate kinase; Provisional; Region: PRK06247 1138877004566 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1138877004567 domain interfaces; other site 1138877004568 active site 1138877004569 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 1138877004570 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1138877004571 active site 1138877004572 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1138877004573 catalytic triad [active] 1138877004574 dimer interface [polypeptide binding]; other site 1138877004575 Uncharacterized conserved protein [Function unknown]; Region: COG2898 1138877004576 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1138877004577 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 1138877004578 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1138877004579 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1138877004580 Walker A/P-loop; other site 1138877004581 Walker A/P-loop; other site 1138877004582 ATP binding site [chemical binding]; other site 1138877004583 ATP binding site [chemical binding]; other site 1138877004584 Q-loop/lid; other site 1138877004585 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 1138877004586 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1138877004587 Walker A/P-loop; other site 1138877004588 ATP binding site [chemical binding]; other site 1138877004589 Q-loop/lid; other site 1138877004590 ABC transporter signature motif; other site 1138877004591 Walker B; other site 1138877004592 D-loop; other site 1138877004593 H-loop/switch region; other site 1138877004594 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1138877004595 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1138877004596 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1138877004597 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1138877004598 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 1138877004599 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 1138877004600 cyclase homology domain; Region: CHD; cd07302 1138877004601 nucleotidyl binding site; other site 1138877004602 metal binding site [ion binding]; metal-binding site 1138877004603 dimer interface [polypeptide binding]; other site 1138877004604 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 1138877004605 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1138877004606 active site 1138877004607 phosphorylation site [posttranslational modification] 1138877004608 intermolecular recognition site; other site 1138877004609 dimerization interface [polypeptide binding]; other site 1138877004610 ANTAR domain; Region: ANTAR; pfam03861 1138877004611 lipid-transfer protein; Provisional; Region: PRK06059 1138877004612 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1138877004613 active site 1138877004614 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1138877004615 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1138877004616 DUF35 OB-fold domain; Region: DUF35; pfam01796 1138877004617 DNA polymerase I; Provisional; Region: PRK05755 1138877004618 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1138877004619 active site 1138877004620 metal binding site 1 [ion binding]; metal-binding site 1138877004621 putative 5' ssDNA interaction site; other site 1138877004622 metal binding site 3; metal-binding site 1138877004623 metal binding site 2 [ion binding]; metal-binding site 1138877004624 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1138877004625 putative DNA binding site [nucleotide binding]; other site 1138877004626 putative metal binding site [ion binding]; other site 1138877004627 3'-5' exonuclease; Region: 35EXOc; smart00474 1138877004628 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1138877004629 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1138877004630 active site 1138877004631 DNA binding site [nucleotide binding] 1138877004632 catalytic site [active] 1138877004633 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 1138877004634 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1138877004635 RNA binding site [nucleotide binding]; other site 1138877004636 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1138877004637 RNA binding site [nucleotide binding]; other site 1138877004638 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1138877004639 RNA binding site [nucleotide binding]; other site 1138877004640 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1138877004641 RNA binding site [nucleotide binding]; other site 1138877004642 dephospho-CoA kinase/protein folding accessory domain-containing protein; Provisional; Region: coaE; PRK03333 1138877004643 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1138877004644 CoA-binding site [chemical binding]; other site 1138877004645 ATP-binding [chemical binding]; other site 1138877004646 Uncharacterized conserved protein [Function unknown]; Region: GrpB; COG2320 1138877004647 Predicted RNA-binding protein, associated with RNAses E/G family [General function prediction only]; Region: COG2306 1138877004648 excinuclease ABC subunit B; Provisional; Region: PRK05298 1138877004649 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1138877004650 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1138877004651 nucleotide binding region [chemical binding]; other site 1138877004652 ATP-binding site [chemical binding]; other site 1138877004653 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1138877004654 UvrB/uvrC motif; Region: UVR; pfam02151 1138877004655 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138877004656 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1138877004657 putative substrate translocation pore; other site 1138877004658 Predicted membrane protein [Function unknown]; Region: COG5305 1138877004659 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1138877004660 Ligand Binding Site [chemical binding]; other site 1138877004661 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1138877004662 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1138877004663 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1138877004664 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1138877004665 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1138877004666 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1138877004667 Predicted esterase [General function prediction only]; Region: COG0627 1138877004668 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 1138877004669 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1138877004670 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1138877004671 dimer interface [polypeptide binding]; other site 1138877004672 putative anticodon binding site; other site 1138877004673 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1138877004674 motif 1; other site 1138877004675 dimer interface [polypeptide binding]; other site 1138877004676 active site 1138877004677 motif 2; other site 1138877004678 motif 3; other site 1138877004679 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1138877004680 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1138877004681 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1138877004682 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1138877004683 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1138877004684 23S rRNA binding site [nucleotide binding]; other site 1138877004685 L21 binding site [polypeptide binding]; other site 1138877004686 L13 binding site [polypeptide binding]; other site 1138877004687 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1138877004688 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1138877004689 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 1138877004690 PE family; Region: PE; pfam00934 1138877004691 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1138877004692 cyclase homology domain; Region: CHD; cd07302 1138877004693 nucleotidyl binding site; other site 1138877004694 metal binding site [ion binding]; metal-binding site 1138877004695 dimer interface [polypeptide binding]; other site 1138877004696 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1138877004697 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1138877004698 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1138877004699 dimer interface [polypeptide binding]; other site 1138877004700 motif 1; other site 1138877004701 active site 1138877004702 motif 2; other site 1138877004703 motif 3; other site 1138877004704 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1138877004705 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1138877004706 putative tRNA-binding site [nucleotide binding]; other site 1138877004707 B3/4 domain; Region: B3_4; pfam03483 1138877004708 tRNA synthetase B5 domain; Region: B5; smart00874 1138877004709 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1138877004710 dimer interface [polypeptide binding]; other site 1138877004711 motif 1; other site 1138877004712 motif 3; other site 1138877004713 motif 2; other site 1138877004714 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1138877004715 PE family; Region: PE; pfam00934 1138877004716 N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850 1138877004717 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1138877004718 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1138877004719 heterotetramer interface [polypeptide binding]; other site 1138877004720 active site pocket [active] 1138877004721 cleavage site 1138877004722 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 1138877004723 feedback inhibition sensing region; other site 1138877004724 homohexameric interface [polypeptide binding]; other site 1138877004725 nucleotide binding site [chemical binding]; other site 1138877004726 N-acetyl-L-glutamate binding site [chemical binding]; other site 1138877004727 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 1138877004728 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1138877004729 inhibitor-cofactor binding pocket; inhibition site 1138877004730 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138877004731 catalytic residue [active] 1138877004732 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1138877004733 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1138877004734 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1138877004735 arginine repressor; Provisional; Region: PRK03341 1138877004736 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1138877004737 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1138877004738 argininosuccinate synthase; Provisional; Region: PRK13820 1138877004739 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1138877004740 ANP binding site [chemical binding]; other site 1138877004741 Substrate Binding Site II [chemical binding]; other site 1138877004742 Substrate Binding Site I [chemical binding]; other site 1138877004743 argininosuccinate lyase; Provisional; Region: PRK00855 1138877004744 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1138877004745 active sites [active] 1138877004746 tetramer interface [polypeptide binding]; other site 1138877004747 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 1138877004748 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 1138877004749 malonyl-CoA binding site [chemical binding]; other site 1138877004750 dimer interface [polypeptide binding]; other site 1138877004751 active site 1138877004752 product binding site; other site 1138877004753 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1138877004754 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1138877004755 active site 1138877004756 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1138877004757 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1138877004758 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138877004759 Enoylreductase; Region: PKS_ER; smart00829 1138877004760 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1138877004761 NAD(P) binding site [chemical binding]; other site 1138877004762 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 1138877004763 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1138877004764 putative NADP binding site [chemical binding]; other site 1138877004765 active site 1138877004766 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1138877004767 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1138877004768 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1138877004769 active site 1138877004770 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1138877004771 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1138877004772 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138877004773 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1138877004774 Enoylreductase; Region: PKS_ER; smart00829 1138877004775 NAD(P) binding site [chemical binding]; other site 1138877004776 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1138877004777 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 1138877004778 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1138877004779 putative NADP binding site [chemical binding]; other site 1138877004780 active site 1138877004781 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1138877004782 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1138877004783 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1138877004784 active site 1138877004785 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1138877004786 putative transposase OrfB; Reviewed; Region: PHA02517 1138877004787 HTH-like domain; Region: HTH_21; pfam13276 1138877004788 Integrase core domain; Region: rve; pfam00665 1138877004789 Integrase core domain; Region: rve_3; pfam13683 1138877004790 Acyl transferase domain; Region: Acyl_transf_1; cl08282 1138877004791 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1138877004792 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 1138877004793 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 1138877004794 malonyl-CoA binding site [chemical binding]; other site 1138877004795 dimer interface [polypeptide binding]; other site 1138877004796 active site 1138877004797 product binding site; other site 1138877004798 Cytochrome P450; Region: p450; cl12078 1138877004799 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138877004800 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1138877004801 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1138877004802 ABC transporter; Region: ABC_tran_2; pfam12848 1138877004803 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1138877004804 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 1138877004805 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138877004806 putative substrate translocation pore; other site 1138877004807 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1138877004808 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1138877004809 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1138877004810 dimerization interface [polypeptide binding]; other site 1138877004811 putative DNA binding site [nucleotide binding]; other site 1138877004812 putative Zn2+ binding site [ion binding]; other site 1138877004813 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1138877004814 active site residue [active] 1138877004815 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1138877004816 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1138877004817 ligand binding site [chemical binding]; other site 1138877004818 flexible hinge region; other site 1138877004819 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1138877004820 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 1138877004821 putative catalytic residues [active] 1138877004822 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 1138877004823 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1138877004824 catalytic residues [active] 1138877004825 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138877004826 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138877004827 active site 1138877004828 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 1138877004829 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1138877004830 substrate binding pocket [chemical binding]; other site 1138877004831 membrane-bound complex binding site; other site 1138877004832 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 1138877004833 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1138877004834 FeS/SAM binding site; other site 1138877004835 DivIVA protein; Region: DivIVA; pfam05103 1138877004836 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1138877004837 acyl-CoA synthetase; Validated; Region: PRK07868 1138877004838 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 1138877004839 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138877004840 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138877004841 acyl-activating enzyme (AAE) consensus motif; other site 1138877004842 AMP binding site [chemical binding]; other site 1138877004843 active site 1138877004844 CoA binding site [chemical binding]; other site 1138877004845 Uncharacterized conserved protein [Function unknown]; Region: COG2835 1138877004846 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138877004847 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138877004848 ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025 1138877004849 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1138877004850 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1138877004851 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 1138877004852 Walker A/P-loop; other site 1138877004853 ATP binding site [chemical binding]; other site 1138877004854 Q-loop/lid; other site 1138877004855 ABC transporter signature motif; other site 1138877004856 Walker B; other site 1138877004857 D-loop; other site 1138877004858 H-loop/switch region; other site 1138877004859 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1138877004860 active site 1138877004861 DNA binding site [nucleotide binding] 1138877004862 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1138877004863 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1138877004864 active site 1138877004865 HIGH motif; other site 1138877004866 dimer interface [polypeptide binding]; other site 1138877004867 KMSKS motif; other site 1138877004868 S4 RNA-binding domain; Region: S4; smart00363 1138877004869 RNA binding surface [nucleotide binding]; other site 1138877004870 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1138877004871 Tetratrico peptide repeat; Region: TPR_5; pfam12688 1138877004872 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1138877004873 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 1138877004874 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 1138877004875 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1138877004876 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1138877004877 RNA binding surface [nucleotide binding]; other site 1138877004878 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138877004879 S-adenosylmethionine binding site [chemical binding]; other site 1138877004880 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 1138877004881 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1138877004882 DNA repair protein RecN; Region: recN; TIGR00634 1138877004883 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1138877004884 Walker A/P-loop; other site 1138877004885 ATP binding site [chemical binding]; other site 1138877004886 Q-loop/lid; other site 1138877004887 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1138877004888 ABC transporter signature motif; other site 1138877004889 Walker B; other site 1138877004890 D-loop; other site 1138877004891 H-loop/switch region; other site 1138877004892 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 1138877004893 Thiamine pyrophosphokinase; Region: TPK; cl08415 1138877004894 Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555 1138877004895 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 1138877004896 CTP synthetase; Validated; Region: pyrG; PRK05380 1138877004897 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1138877004898 Catalytic site [active] 1138877004899 active site 1138877004900 UTP binding site [chemical binding]; other site 1138877004901 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1138877004902 active site 1138877004903 putative oxyanion hole; other site 1138877004904 catalytic triad [active] 1138877004905 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1138877004906 dimer interface [polypeptide binding]; other site 1138877004907 ADP-ribose binding site [chemical binding]; other site 1138877004908 active site 1138877004909 nudix motif; other site 1138877004910 metal binding site [ion binding]; metal-binding site 1138877004911 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1138877004912 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1138877004913 active site 1138877004914 DNA binding site [nucleotide binding] 1138877004915 Int/Topo IB signature motif; other site 1138877004916 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1138877004917 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1138877004918 active site 1138877004919 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1138877004920 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138877004921 S-adenosylmethionine binding site [chemical binding]; other site 1138877004922 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 1138877004923 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138877004924 PPE family; Region: PPE; pfam00823 1138877004925 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1138877004926 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138877004927 PPE family; Region: PPE; pfam00823 1138877004928 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1138877004929 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1138877004930 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1138877004931 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1138877004932 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1138877004933 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1138877004934 P-loop; other site 1138877004935 Magnesium ion binding site [ion binding]; other site 1138877004936 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1138877004937 Magnesium ion binding site [ion binding]; other site 1138877004938 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 1138877004939 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 1138877004940 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1138877004941 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1138877004942 RNA binding surface [nucleotide binding]; other site 1138877004943 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1138877004944 active site 1138877004945 cytidylate kinase; Provisional; Region: cmk; PRK00023 1138877004946 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1138877004947 CMP-binding site; other site 1138877004948 The sites determining sugar specificity; other site 1138877004949 GTP-binding protein Der; Reviewed; Region: PRK03003 1138877004950 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1138877004951 GTP/Mg2+ binding site [chemical binding]; other site 1138877004952 Switch I region; other site 1138877004953 G2 box; other site 1138877004954 Switch II region; other site 1138877004955 G3 box; other site 1138877004956 G4 box; other site 1138877004957 G5 box; other site 1138877004958 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1138877004959 G1 box; other site 1138877004960 GTP/Mg2+ binding site [chemical binding]; other site 1138877004961 Switch I region; other site 1138877004962 G2 box; other site 1138877004963 G3 box; other site 1138877004964 Switch II region; other site 1138877004965 G4 box; other site 1138877004966 G5 box; other site 1138877004967 short chain dehydrogenase; Provisional; Region: PRK07060 1138877004968 classical (c) SDRs; Region: SDR_c; cd05233 1138877004969 NAD(P) binding site [chemical binding]; other site 1138877004970 active site 1138877004971 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 1138877004972 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1138877004973 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1138877004974 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 1138877004975 Cupin domain; Region: Cupin_2; pfam07883 1138877004976 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 1138877004977 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1138877004978 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1138877004979 putative switch regulator; other site 1138877004980 non-specific DNA interactions [nucleotide binding]; other site 1138877004981 DNA binding site [nucleotide binding] 1138877004982 sequence specific DNA binding site [nucleotide binding]; other site 1138877004983 putative cAMP binding site [chemical binding]; other site 1138877004984 Bacterial transcriptional regulator; Region: IclR; pfam01614 1138877004985 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 1138877004986 putative active site [active] 1138877004987 homotetrameric interface [polypeptide binding]; other site 1138877004988 metal binding site [ion binding]; metal-binding site 1138877004989 biotin carboxylase-like protein; Validated; Region: PRK06524 1138877004990 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1138877004991 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1138877004992 Beta-lactamase; Region: Beta-lactamase; pfam00144 1138877004993 Predicted transcriptional regulators [Transcription]; Region: COG1733 1138877004994 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1138877004995 dimerization interface [polypeptide binding]; other site 1138877004996 putative DNA binding site [nucleotide binding]; other site 1138877004997 putative Zn2+ binding site [ion binding]; other site 1138877004998 Predicted transcriptional regulators [Transcription]; Region: COG1733 1138877004999 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1138877005000 FAD binding domain; Region: FAD_binding_4; pfam01565 1138877005001 Berberine and berberine like; Region: BBE; pfam08031 1138877005002 TIGR03086 family protein; Region: TIGR03086 1138877005003 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1138877005004 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138877005005 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1138877005006 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1138877005007 Beta-lactamase; Region: Beta-lactamase; pfam00144 1138877005008 succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407 1138877005009 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101 1138877005010 NAD(P) binding site [chemical binding]; other site 1138877005011 catalytic residues [active] 1138877005012 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 1138877005013 putative catalytic residue [active] 1138877005014 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes [Energy production and conversion]; Region: AceF; COG0508 1138877005015 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1138877005016 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 1138877005017 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_1; cd09319 1138877005018 gating phenylalanine in ion channel; other site 1138877005019 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 1138877005020 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1138877005021 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 1138877005022 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 1138877005023 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138877005024 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 1138877005025 putative substrate translocation pore; other site 1138877005026 Domain of unknown function (DUF1876); Region: DUF1876; pfam08962 1138877005027 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1138877005028 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1138877005029 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1138877005030 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1138877005031 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4423 1138877005032 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3742 1138877005033 putative active site [active] 1138877005034 Protein tyrosine kinase; Region: Pkinase_Tyr; pfam07714 1138877005035 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1138877005036 active site 1138877005037 ATP binding site [chemical binding]; other site 1138877005038 substrate binding site [chemical binding]; other site 1138877005039 activation loop (A-loop); other site 1138877005040 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1138877005041 Thioredoxin; Region: Thioredoxin_4; cl17273 1138877005042 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 1138877005043 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 1138877005044 active site 1138877005045 metal binding site [ion binding]; metal-binding site 1138877005046 nudix motif; other site 1138877005047 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1138877005048 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1138877005049 active site 1138877005050 ATP binding site [chemical binding]; other site 1138877005051 substrate binding site [chemical binding]; other site 1138877005052 activation loop (A-loop); other site 1138877005053 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1138877005054 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1138877005055 phosphopeptide binding site; other site 1138877005056 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1138877005057 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1138877005058 phosphopeptide binding site; other site 1138877005059 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 1138877005060 The Eye Pigment Precursor Transporter (EPP) Family protein; Region: 3a01204; TIGR00955 1138877005061 Walker A/P-loop; other site 1138877005062 ATP binding site [chemical binding]; other site 1138877005063 Q-loop/lid; other site 1138877005064 ABC transporter signature motif; other site 1138877005065 Walker B; other site 1138877005066 D-loop; other site 1138877005067 H-loop/switch region; other site 1138877005068 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1138877005069 acyl-CoA synthetase; Provisional; Region: PRK13388 1138877005070 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138877005071 acyl-activating enzyme (AAE) consensus motif; other site 1138877005072 AMP binding site [chemical binding]; other site 1138877005073 active site 1138877005074 CoA binding site [chemical binding]; other site 1138877005075 hypothetical protein; Provisional; Region: PRK06185 1138877005076 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1138877005077 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1138877005078 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1138877005079 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138877005080 PPE family; Region: PPE; pfam00823 1138877005081 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1138877005082 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1138877005083 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 1138877005084 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1138877005085 Transposase; Region: HTH_Tnp_1; cl17663 1138877005086 putative transposase OrfB; Reviewed; Region: PHA02517 1138877005087 HTH-like domain; Region: HTH_21; pfam13276 1138877005088 Integrase core domain; Region: rve; pfam00665 1138877005089 Integrase core domain; Region: rve_3; pfam13683 1138877005090 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 1138877005091 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1138877005092 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1138877005093 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1138877005094 sulfite oxidase; Provisional; Region: PLN00177 1138877005095 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 1138877005096 Moco binding site; other site 1138877005097 metal coordination site [ion binding]; other site 1138877005098 dimerization interface [polypeptide binding]; other site 1138877005099 Transport protein; Region: actII; TIGR00833 1138877005100 Cutinase; Region: Cutinase; pfam01083 1138877005101 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1138877005102 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1138877005103 Uncharacterized conserved protein [Function unknown]; Region: COG0393 1138877005104 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 1138877005105 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1138877005106 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1138877005107 active site 1138877005108 Integrase core domain; Region: rve; pfam00665 1138877005109 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 1138877005110 putative homotetramer interface [polypeptide binding]; other site 1138877005111 putative homodimer interface [polypeptide binding]; other site 1138877005112 putative allosteric switch controlling residues; other site 1138877005113 putative metal binding site [ion binding]; other site 1138877005114 putative homodimer-homodimer interface [polypeptide binding]; other site 1138877005115 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1138877005116 PE family; Region: PE; pfam00934 1138877005117 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 1138877005118 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813 1138877005119 dimer interface [polypeptide binding]; other site 1138877005120 active site 1138877005121 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1138877005122 substrate binding site [chemical binding]; other site 1138877005123 catalytic residue [active] 1138877005124 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 1138877005125 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1138877005126 metal binding site [ion binding]; metal-binding site 1138877005127 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 1138877005128 FAD binding domain; Region: FAD_binding_4; pfam01565 1138877005129 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 1138877005130 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 1138877005131 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1138877005132 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1138877005133 Bacterial transcriptional regulator; Region: IclR; pfam01614 1138877005134 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1138877005135 FAD binding domain; Region: FAD_binding_4; pfam01565 1138877005136 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138877005137 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138877005138 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138877005139 Cytochrome P450; Region: p450; cl12078 1138877005140 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362 1138877005141 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 1138877005142 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 1138877005143 Protein of unknown function (DUF690); Region: DUF690; pfam05108 1138877005144 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1138877005145 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1138877005146 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1138877005147 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1138877005148 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138877005149 Cytochrome P450; Region: p450; cl12078 1138877005150 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1138877005151 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138877005152 PPE family; Region: PPE; pfam00823 1138877005153 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1138877005154 PE family; Region: PE; pfam00934 1138877005155 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138877005156 PPE family; Region: PPE; pfam00823 1138877005157 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1138877005158 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138877005159 PPE family; Region: PPE; pfam00823 1138877005160 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1138877005161 PE family; Region: PE; pfam00934 1138877005162 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1138877005163 EspG family; Region: ESX-1_EspG; pfam14011 1138877005164 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 1138877005165 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1138877005166 catalytic residues [active] 1138877005167 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 1138877005168 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 1138877005169 active site 1138877005170 catalytic residues [active] 1138877005171 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 1138877005172 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 1138877005173 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138877005174 Walker A motif; other site 1138877005175 ATP binding site [chemical binding]; other site 1138877005176 Walker B motif; other site 1138877005177 arginine finger; other site 1138877005178 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138877005179 PPE family; Region: PPE; pfam00823 1138877005180 PE-PPE domain; Region: PE-PPE; pfam08237 1138877005181 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138877005182 PPE family; Region: PPE; pfam00823 1138877005183 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138877005184 PPE family; Region: PPE; pfam00823 1138877005185 PE family; Region: PE; pfam00934 1138877005186 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1138877005187 PE family; Region: PE; pfam00934 1138877005188 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138877005189 PPE family; Region: PPE; pfam00823 1138877005190 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138877005191 PPE family; Region: PPE; pfam00823 1138877005192 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138877005193 PPE family; Region: PPE; pfam00823 1138877005194 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1138877005195 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1138877005196 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1138877005197 MgtC family; Region: MgtC; pfam02308 1138877005198 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1138877005199 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1138877005200 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 1138877005201 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 1138877005202 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 1138877005203 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138877005204 hypothetical protein; Validated; Region: PRK07121 1138877005205 PE family; Region: PE; pfam00934 1138877005206 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 1138877005207 ABC transporter transmembrane region 2; Region: ABC_membrane_2; pfam06472 1138877005208 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 1138877005209 hypothetical protein; Provisional; Region: PRK05858 1138877005210 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1138877005211 PYR/PP interface [polypeptide binding]; other site 1138877005212 dimer interface [polypeptide binding]; other site 1138877005213 TPP binding site [chemical binding]; other site 1138877005214 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1138877005215 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 1138877005216 TPP-binding site; other site 1138877005217 dimer interface [polypeptide binding]; other site 1138877005218 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 1138877005219 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 1138877005220 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1138877005221 nucleotide binding region [chemical binding]; other site 1138877005222 ATP-binding site [chemical binding]; other site 1138877005223 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1138877005224 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 1138877005225 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1138877005226 Uncharacterized conserved protein (small basic protein) [Function unknown]; Region: Sbp; COG3856 1138877005227 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 1138877005228 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1138877005229 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1138877005230 lipoyl attachment site [posttranslational modification]; other site 1138877005231 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1138877005232 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1138877005233 phosphopeptide binding site; other site 1138877005234 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1138877005235 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1138877005236 DNA binding residues [nucleotide binding] 1138877005237 Bifunctional nuclease; Region: DNase-RNase; pfam02577 1138877005238 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1138877005239 DNA binding residues [nucleotide binding] 1138877005240 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1138877005241 putative dimer interface [polypeptide binding]; other site 1138877005242 glycine dehydrogenase; Provisional; Region: PRK05367 1138877005243 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1138877005244 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138877005245 tetramer interface [polypeptide binding]; other site 1138877005246 catalytic residue [active] 1138877005247 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1138877005248 tetramer interface [polypeptide binding]; other site 1138877005249 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138877005250 catalytic residue [active] 1138877005251 haloalkane dehalogenase; Provisional; Region: PRK03204 1138877005252 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1138877005253 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 1138877005254 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 1138877005255 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1138877005256 metal ion-dependent adhesion site (MIDAS); other site 1138877005257 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 1138877005258 active site 1138877005259 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 1138877005260 putative active site [active] 1138877005261 Domain of unknown function DUF21; Region: DUF21; pfam01595 1138877005262 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1138877005263 FOG: CBS domain [General function prediction only]; Region: COG0517 1138877005264 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1138877005265 Domain of unknown function DUF21; Region: DUF21; pfam01595 1138877005266 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1138877005267 Transporter associated domain; Region: CorC_HlyC; smart01091 1138877005268 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 1138877005269 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1138877005270 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1138877005271 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1138877005272 active site 1138877005273 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1138877005274 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1138877005275 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1138877005276 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1138877005277 Predicted transcriptional regulator [Transcription]; Region: COG3682 1138877005278 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1138877005279 CoenzymeA binding site [chemical binding]; other site 1138877005280 subunit interaction site [polypeptide binding]; other site 1138877005281 PHB binding site; other site 1138877005282 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 1138877005283 alpha-gamma subunit interface [polypeptide binding]; other site 1138877005284 beta-gamma subunit interface [polypeptide binding]; other site 1138877005285 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 1138877005286 gamma-beta subunit interface [polypeptide binding]; other site 1138877005287 alpha-beta subunit interface [polypeptide binding]; other site 1138877005288 urease subunit alpha; Reviewed; Region: ureC; PRK13206 1138877005289 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 1138877005290 subunit interactions [polypeptide binding]; other site 1138877005291 active site 1138877005292 flap region; other site 1138877005293 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 1138877005294 UreF; Region: UreF; pfam01730 1138877005295 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1138877005296 UreD urease accessory protein; Region: UreD; cl00530 1138877005297 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1138877005298 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1138877005299 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 1138877005300 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1138877005301 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1138877005302 classical (c) SDRs; Region: SDR_c; cd05233 1138877005303 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 1138877005304 NAD(P) binding site [chemical binding]; other site 1138877005305 active site 1138877005306 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 1138877005307 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1138877005308 sulfate transport protein; Provisional; Region: cysT; CHL00187 1138877005309 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1138877005310 dimer interface [polypeptide binding]; other site 1138877005311 conserved gate region; other site 1138877005312 putative PBP binding loops; other site 1138877005313 ABC-ATPase subunit interface; other site 1138877005314 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 1138877005315 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1138877005316 Walker A/P-loop; other site 1138877005317 ATP binding site [chemical binding]; other site 1138877005318 Q-loop/lid; other site 1138877005319 ABC transporter signature motif; other site 1138877005320 Walker B; other site 1138877005321 D-loop; other site 1138877005322 H-loop/switch region; other site 1138877005323 TOBE domain; Region: TOBE; pfam03459 1138877005324 Fibronectin-attachment protein (FAP); Region: FAP; pfam07174 1138877005325 Predicted membrane protein [Function unknown]; Region: COG2261 1138877005326 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 1138877005327 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822 1138877005328 putative NAD(P) binding site [chemical binding]; other site 1138877005329 putative substrate binding site [chemical binding]; other site 1138877005330 catalytic Zn binding site [ion binding]; other site 1138877005331 structural Zn binding site [ion binding]; other site 1138877005332 CAAX protease self-immunity; Region: Abi; pfam02517 1138877005333 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 1138877005334 MOSC domain; Region: MOSC; pfam03473 1138877005335 short chain dehydrogenase; Provisional; Region: PRK07825 1138877005336 classical (c) SDRs; Region: SDR_c; cd05233 1138877005337 NAD(P) binding site [chemical binding]; other site 1138877005338 active site 1138877005339 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1138877005340 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1138877005341 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1138877005342 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1138877005343 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 1138877005344 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1138877005345 active site 1138877005346 hypothetical protein; Provisional; Region: PRK12320 1138877005347 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138877005348 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 1138877005349 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1138877005350 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1138877005351 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1138877005352 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 1138877005353 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 1138877005354 active site 1138877005355 substrate binding site [chemical binding]; other site 1138877005356 FMN binding site [chemical binding]; other site 1138877005357 putative catalytic residues [active] 1138877005358 Uncharacterized conserved protein [Function unknown]; Region: COG5579 1138877005359 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1138877005360 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 1138877005361 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 1138877005362 heme binding site [chemical binding]; other site 1138877005363 ferroxidase pore; other site 1138877005364 ferroxidase diiron center [ion binding]; other site 1138877005365 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138877005366 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1138877005367 putative substrate translocation pore; other site 1138877005368 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138877005369 putative substrate translocation pore; other site 1138877005370 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cl00333 1138877005371 23S rRNA interface [nucleotide binding]; other site 1138877005372 L3 interface [polypeptide binding]; other site 1138877005373 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1138877005374 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1138877005375 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1138877005376 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 1138877005377 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138877005378 Cytochrome P450; Region: p450; cl12078 1138877005379 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 1138877005380 short chain dehydrogenase; Provisional; Region: PRK08267 1138877005381 classical (c) SDR, subgroup 9; Region: SDR_c9; cd08931 1138877005382 putative NAD(P) binding site [chemical binding]; other site 1138877005383 active site 1138877005384 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1138877005385 hydrophobic ligand binding site; other site 1138877005386 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1138877005387 chorismate mutase; Provisional; Region: PRK09269 1138877005388 chorismate mutase, putative; Region: CM_mono2; TIGR01806 1138877005389 Putative esterase; Region: Esterase; pfam00756 1138877005390 Leucine carboxyl methyltransferase; Region: LCM; cl01306 1138877005391 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138877005392 Leucine carboxyl methyltransferase; Region: LCM; cl01306 1138877005393 Uncharacterized conserved protein [Function unknown]; Region: COG2353 1138877005394 Nitronate monooxygenase; Region: NMO; pfam03060 1138877005395 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1138877005396 FMN binding site [chemical binding]; other site 1138877005397 substrate binding site [chemical binding]; other site 1138877005398 putative catalytic residue [active] 1138877005399 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 2; Region: FDH_like_2; cd08284 1138877005400 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1138877005401 catalytic Zn binding site [ion binding]; other site 1138877005402 NAD(P) binding site [chemical binding]; other site 1138877005403 structural Zn binding site [ion binding]; other site 1138877005404 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138877005405 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1138877005406 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1138877005407 dimerization interface [polypeptide binding]; other site 1138877005408 putative tRNAtyr binding site [nucleotide binding]; other site 1138877005409 putative active site [active] 1138877005410 Domain of unknown function DUF77; Region: DUF77; pfam01910 1138877005411 Macro domain, Unknown family 2. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_2; cd03330 1138877005412 putative ADP-ribose binding site [chemical binding]; other site 1138877005413 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138877005414 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1138877005415 cyclase homology domain; Region: CHD; cd07302 1138877005416 nucleotidyl binding site; other site 1138877005417 metal binding site [ion binding]; metal-binding site 1138877005418 dimer interface [polypeptide binding]; other site 1138877005419 competence damage-inducible protein A; Provisional; Region: PRK00549 1138877005420 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1138877005421 putative MPT binding site; other site 1138877005422 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 1138877005423 putative sialic acid transporter; Region: 2A0112; TIGR00891 1138877005424 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138877005425 putative substrate translocation pore; other site 1138877005426 Predicted membrane protein [Function unknown]; Region: COG1950 1138877005427 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1138877005428 anti sigma factor interaction site; other site 1138877005429 regulatory phosphorylation site [posttranslational modification]; other site 1138877005430 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1138877005431 Domain of unknown function (DUF4262); Region: DUF4262; pfam14081 1138877005432 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 1138877005433 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 1138877005434 dimer interface [polypeptide binding]; other site 1138877005435 active site 1138877005436 heme binding site [chemical binding]; other site 1138877005437 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 1138877005438 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1138877005439 metal binding site 2 [ion binding]; metal-binding site 1138877005440 putative DNA binding helix; other site 1138877005441 metal binding site 1 [ion binding]; metal-binding site 1138877005442 dimer interface [polypeptide binding]; other site 1138877005443 structural Zn2+ binding site [ion binding]; other site 1138877005444 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1138877005445 substrate binding site [chemical binding]; other site 1138877005446 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1138877005447 substrate binding site [chemical binding]; other site 1138877005448 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1138877005449 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR3; cd08275 1138877005450 putative NAD(P) binding site [chemical binding]; other site 1138877005451 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1138877005452 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1138877005453 tetramer interface [polypeptide binding]; other site 1138877005454 active site 1138877005455 Mg2+/Mn2+ binding site [ion binding]; other site 1138877005456 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435 1138877005457 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138877005458 PPE family; Region: PPE; pfam00823 1138877005459 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138877005460 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1138877005461 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1138877005462 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138877005463 PPE family; Region: PPE; pfam00823 1138877005464 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1138877005465 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1138877005466 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 1138877005467 putative hydrophobic ligand binding site [chemical binding]; other site 1138877005468 protein interface [polypeptide binding]; other site 1138877005469 gate; other site 1138877005470 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1138877005471 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 1138877005472 putative acyl-acceptor binding pocket; other site 1138877005473 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1138877005474 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1138877005475 Beta-lactamase; Region: Beta-lactamase; pfam00144 1138877005476 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1138877005477 Beta-lactamase; Region: Beta-lactamase; pfam00144 1138877005478 putative fatty-acid--CoA ligase; Provisional; Region: PRK12476 1138877005479 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1138877005480 acyl-activating enzyme (AAE) consensus motif; other site 1138877005481 active site 1138877005482 Domain of unknown function (DUF1942); Region: DUF1942; pfam09167 1138877005483 Uncharacterized conserved protein [Function unknown]; Region: COG3361 1138877005484 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138877005485 TIGR03085 family protein; Region: TIGR03085 1138877005486 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1138877005487 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1138877005488 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 1138877005489 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1138877005490 conserved cys residue [active] 1138877005491 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1138877005492 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1138877005493 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1138877005494 dimer interface [polypeptide binding]; other site 1138877005495 catalytic triad [active] 1138877005496 peroxidatic and resolving cysteines [active] 1138877005497 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138877005498 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1138877005499 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1138877005500 active site 1138877005501 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138877005502 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 1138877005503 FAD binding site [chemical binding]; other site 1138877005504 substrate binding site [chemical binding]; other site 1138877005505 catalytic base [active] 1138877005506 enoyl-CoA hydratase; Provisional; Region: PRK08290 1138877005507 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138877005508 substrate binding site [chemical binding]; other site 1138877005509 oxyanion hole (OAH) forming residues; other site 1138877005510 trimer interface [polypeptide binding]; other site 1138877005511 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1138877005512 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1138877005513 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 1138877005514 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1138877005515 catalytic loop [active] 1138877005516 iron binding site [ion binding]; other site 1138877005517 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 1138877005518 FAD binding pocket [chemical binding]; other site 1138877005519 FAD binding motif [chemical binding]; other site 1138877005520 phosphate binding motif [ion binding]; other site 1138877005521 beta-alpha-beta structure motif; other site 1138877005522 NAD binding pocket [chemical binding]; other site 1138877005523 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138877005524 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1138877005525 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1138877005526 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 1138877005527 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1138877005528 GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807 1138877005529 dimerization interface [polypeptide binding]; other site 1138877005530 active site 1138877005531 classical (c) SDR, subgroup 12; Region: SDR_c12; cd08944 1138877005532 putative NAD(P) binding site [chemical binding]; other site 1138877005533 active site 1138877005534 homodimer interface [polypeptide binding]; other site 1138877005535 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 1138877005536 SEC-C motif; Region: SEC-C; pfam02810 1138877005537 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1138877005538 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1138877005539 active site 1138877005540 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 1138877005541 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: VapC; COG1487 1138877005542 YjzC-like protein; Region: YjzC; pfam14168 1138877005543 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 1138877005544 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1138877005545 non-specific DNA binding site [nucleotide binding]; other site 1138877005546 salt bridge; other site 1138877005547 sequence-specific DNA binding site [nucleotide binding]; other site 1138877005548 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 1138877005549 Uncharacterized protein family (UPF0156); Region: RHH_2; pfam03693 1138877005550 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 1138877005551 putative active site [active] 1138877005552 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1138877005553 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138877005554 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138877005555 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138877005556 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138877005557 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1138877005558 Permease; Region: Permease; pfam02405 1138877005559 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1138877005560 Permease; Region: Permease; pfam02405 1138877005561 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138877005562 mce related protein; Region: MCE; pfam02470 1138877005563 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1138877005564 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138877005565 mce related protein; Region: MCE; pfam02470 1138877005566 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138877005567 mce related protein; Region: MCE; pfam02470 1138877005568 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138877005569 mce related protein; Region: MCE; pfam02470 1138877005570 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138877005571 mce related protein; Region: MCE; pfam02470 1138877005572 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138877005573 mce related protein; Region: MCE; pfam02470 1138877005574 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1138877005575 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1138877005576 YacP-like NYN domain; Region: NYN_YacP; cl01491 1138877005577 Peptidase family M48; Region: Peptidase_M48; pfam01435 1138877005578 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138877005579 S-adenosylmethionine binding site [chemical binding]; other site 1138877005580 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1138877005581 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1138877005582 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1138877005583 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1138877005584 dimer interface [polypeptide binding]; other site 1138877005585 putative radical transfer pathway; other site 1138877005586 diiron center [ion binding]; other site 1138877005587 tyrosyl radical; other site 1138877005588 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 1138877005589 putative active site [active] 1138877005590 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4423 1138877005591 PE family; Region: PE; pfam00934 1138877005592 Cutinase; Region: Cutinase; pfam01083 1138877005593 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 1138877005594 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1138877005595 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1138877005596 dimerization interface [polypeptide binding]; other site 1138877005597 Lysine efflux permease [General function prediction only]; Region: COG1279 1138877005598 Cellulose binding domain; Region: CBM_2; pfam00553 1138877005599 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138877005600 S-adenosylmethionine binding site [chemical binding]; other site 1138877005601 Uncharacterized conserved protein [Function unknown]; Region: COG5654 1138877005602 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 1138877005603 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 1138877005604 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138877005605 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 1138877005606 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1138877005607 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 1138877005608 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1138877005609 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 1138877005610 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1138877005611 dimerization interface [polypeptide binding]; other site 1138877005612 putative DNA binding site [nucleotide binding]; other site 1138877005613 putative Zn2+ binding site [ion binding]; other site 1138877005614 Hemerythrin-like domain; Region: Hr-like; cd12108 1138877005615 Fe binding site [ion binding]; other site 1138877005616 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1138877005617 Ligand Binding Site [chemical binding]; other site 1138877005618 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1138877005619 Ligand Binding Site [chemical binding]; other site 1138877005620 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1138877005621 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1138877005622 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1138877005623 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1138877005624 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1138877005625 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1138877005626 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1138877005627 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1138877005628 tetramer interface [polypeptide binding]; other site 1138877005629 active site 1138877005630 Mg2+/Mn2+ binding site [ion binding]; other site 1138877005631 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1138877005632 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1138877005633 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 1138877005634 3beta17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 3beta-17beta-HSD_like_SDR_c; cd05341 1138877005635 homotetramer interface [polypeptide binding]; other site 1138877005636 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1138877005637 NAD binding site [chemical binding]; other site 1138877005638 homodimer interface [polypeptide binding]; other site 1138877005639 active site 1138877005640 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1138877005641 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138877005642 S-adenosylmethionine binding site [chemical binding]; other site 1138877005643 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 1138877005644 Predicted kinase [General function prediction only]; Region: COG0645 1138877005645 AAA domain; Region: AAA_17; pfam13207 1138877005646 Universal stress protein family; Region: Usp; pfam00582 1138877005647 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1138877005648 Ligand Binding Site [chemical binding]; other site 1138877005649 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 1138877005650 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 1138877005651 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 1138877005652 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 1138877005653 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1138877005654 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1138877005655 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 1138877005656 Ferredoxin [Energy production and conversion]; Region: COG1146 1138877005657 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1138877005658 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 1138877005659 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138877005660 Walker A motif; other site 1138877005661 ATP binding site [chemical binding]; other site 1138877005662 Walker B motif; other site 1138877005663 arginine finger; other site 1138877005664 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 1138877005665 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 1138877005666 putative active site [active] 1138877005667 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1138877005668 MarR family; Region: MarR_2; pfam12802 1138877005669 Phage envelope protein [General function prediction only]; Region: COG5562 1138877005670 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1138877005671 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1138877005672 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1138877005673 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1138877005674 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1138877005675 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1138877005676 active site 1138877005677 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1138877005678 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1138877005679 non-specific DNA binding site [nucleotide binding]; other site 1138877005680 salt bridge; other site 1138877005681 sequence-specific DNA binding site [nucleotide binding]; other site 1138877005682 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 1138877005683 Uncharacterized conserved protein [Function unknown]; Region: COG2442 1138877005684 Predicted helicase [General function prediction only]; Region: COG4889 1138877005685 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1138877005686 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1138877005687 non-specific DNA binding site [nucleotide binding]; other site 1138877005688 salt bridge; other site 1138877005689 sequence-specific DNA binding site [nucleotide binding]; other site 1138877005690 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4683 1138877005691 Predicted helicase [General function prediction only]; Region: COG4889 1138877005692 Restriction endonuclease; Region: Mrr_cat_2; pfam13156 1138877005693 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 1138877005694 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1138877005695 ATP binding site [chemical binding]; other site 1138877005696 putative Mg++ binding site [ion binding]; other site 1138877005697 Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271 1138877005698 ATP-binding site [chemical binding]; other site 1138877005699 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1138877005700 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1138877005701 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1138877005702 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1138877005703 Ligand Binding Site [chemical binding]; other site 1138877005704 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1138877005705 Ligand Binding Site [chemical binding]; other site 1138877005706 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1138877005707 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1138877005708 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1138877005709 Histidine kinase; Region: HisKA_3; pfam07730 1138877005710 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1138877005711 Ligand Binding Site [chemical binding]; other site 1138877005712 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1138877005713 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1138877005714 putative substrate binding site [chemical binding]; other site 1138877005715 putative ATP binding site [chemical binding]; other site 1138877005716 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1138877005717 active site 1138877005718 Erythromycin esterase homolog [General function prediction only]; Region: COG2312 1138877005719 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1138877005720 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1138877005721 putative dimer interface [polypeptide binding]; other site 1138877005722 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1138877005723 dimer interface [polypeptide binding]; other site 1138877005724 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 1138877005725 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1138877005726 putative DNA binding site [nucleotide binding]; other site 1138877005727 dimerization interface [polypeptide binding]; other site 1138877005728 putative Zn2+ binding site [ion binding]; other site 1138877005729 Ligand-binding SRPBCC domain of Micromonospora echinospora CalC and related proteins; Region: SRPBCC_CalC; cd08891 1138877005730 putative hydrophobic ligand binding site [chemical binding]; other site 1138877005731 CLM binding site; other site 1138877005732 L1 loop; other site 1138877005733 DNA binding site [nucleotide binding] 1138877005734 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1138877005735 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1138877005736 MDMPI C-terminal domain; Region: MDMPI_C; pfam07398 1138877005737 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1138877005738 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 1138877005739 nucleophile elbow; other site 1138877005740 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1138877005741 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1138877005742 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1138877005743 Walker A/P-loop; other site 1138877005744 ATP binding site [chemical binding]; other site 1138877005745 Q-loop/lid; other site 1138877005746 ABC transporter signature motif; other site 1138877005747 Walker B; other site 1138877005748 D-loop; other site 1138877005749 H-loop/switch region; other site 1138877005750 TOBE domain; Region: TOBE_2; pfam08402 1138877005751 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1138877005752 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1138877005753 dimer interface [polypeptide binding]; other site 1138877005754 conserved gate region; other site 1138877005755 putative PBP binding loops; other site 1138877005756 ABC-ATPase subunit interface; other site 1138877005757 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1138877005758 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1138877005759 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 1138877005760 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 1138877005761 Isochorismatase family; Region: Isochorismatase; pfam00857 1138877005762 catalytic triad [active] 1138877005763 metal binding site [ion binding]; metal-binding site 1138877005764 conserved cis-peptide bond; other site 1138877005765 Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861 1138877005766 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1138877005767 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1138877005768 substrate binding pocket [chemical binding]; other site 1138877005769 catalytic triad [active] 1138877005770 hypothetical protein; Provisional; Region: PRK05865 1138877005771 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138877005772 NAD(P) binding site [chemical binding]; other site 1138877005773 active site 1138877005774 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1138877005775 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1138877005776 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1138877005777 active site 1138877005778 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1138877005779 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1138877005780 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138877005781 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1138877005782 Enoylreductase; Region: PKS_ER; smart00829 1138877005783 NAD(P) binding site [chemical binding]; other site 1138877005784 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 1138877005785 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1138877005786 putative NADP binding site [chemical binding]; other site 1138877005787 active site 1138877005788 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1138877005789 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1138877005790 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1138877005791 active site 1138877005792 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1138877005793 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1138877005794 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138877005795 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1138877005796 Enoylreductase; Region: PKS_ER; smart00829 1138877005797 NAD(P) binding site [chemical binding]; other site 1138877005798 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 1138877005799 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1138877005800 putative NADP binding site [chemical binding]; other site 1138877005801 active site 1138877005802 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1138877005803 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 1138877005804 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 1138877005805 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1138877005806 putative active site [active] 1138877005807 catalytic triad [active] 1138877005808 putative dimer interface [polypeptide binding]; other site 1138877005809 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 1138877005810 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 1138877005811 Ligand binding site; other site 1138877005812 Putative Catalytic site; other site 1138877005813 DXD motif; other site 1138877005814 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1138877005815 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1138877005816 active site 1138877005817 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 1138877005818 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1138877005819 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 1138877005820 30S ribosomal protein S18; Provisional; Region: PRK13401 1138877005821 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1138877005822 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1138877005823 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1138877005824 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1138877005825 intersubunit interface [polypeptide binding]; other site 1138877005826 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1138877005827 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1138877005828 PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666 1138877005829 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 1138877005830 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1138877005831 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1138877005832 PemK-like protein; Region: PemK; pfam02452 1138877005833 precorrin-3B synthase; Region: CobG; TIGR02435 1138877005834 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1138877005835 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 1138877005836 Precorrin-8X methylmutase; Region: CbiC; pfam02570 1138877005837 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 1138877005838 active site 1138877005839 SAM binding site [chemical binding]; other site 1138877005840 homodimer interface [polypeptide binding]; other site 1138877005841 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 1138877005842 active site 1138877005843 SAM binding site [chemical binding]; other site 1138877005844 homodimer interface [polypeptide binding]; other site 1138877005845 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1138877005846 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138877005847 S-adenosylmethionine binding site [chemical binding]; other site 1138877005848 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 1138877005849 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1138877005850 RNA polymerase sigma factor SigC; Reviewed; Region: PRK09649 1138877005851 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1138877005852 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1138877005853 DNA binding residues [nucleotide binding] 1138877005854 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 1138877005855 precorrin-6x reductase; Region: precor6x_red; TIGR00715 1138877005856 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 1138877005857 active site 1138877005858 SAM binding site [chemical binding]; other site 1138877005859 homodimer interface [polypeptide binding]; other site 1138877005860 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 1138877005861 active site 1138877005862 putative homodimer interface [polypeptide binding]; other site 1138877005863 SAM binding site [chemical binding]; other site 1138877005864 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 1138877005865 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1138877005866 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138877005867 NAD(P) binding site [chemical binding]; other site 1138877005868 active site 1138877005869 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1138877005870 Catalytic domain of uncharacterized Mycobacterium tuberculosis Rv2075c-like proteins; Region: PI-PLCc_Rv2075c_like; cd08590 1138877005871 putative active site [active] 1138877005872 catalytic site [active] 1138877005873 putative metal binding site [ion binding]; other site 1138877005874 C-type lectin (CTL)/C-type lectin-like (CTLD) domain; Region: CLECT; cl02432 1138877005875 Protein of unknown function (DUF2563); Region: DUF2563; pfam10817 1138877005876 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 1138877005877 putative transposase OrfB; Reviewed; Region: PHA02517 1138877005878 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1138877005879 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1138877005880 active site 1138877005881 ATP binding site [chemical binding]; other site 1138877005882 substrate binding site [chemical binding]; other site 1138877005883 activation loop (A-loop); other site 1138877005884 PknH-like extracellular domain; Region: PknH_C; pfam14032 1138877005885 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1138877005886 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1138877005887 active site 1138877005888 5'-3' exonuclease, N-terminal resolvase-like domain; Region: 5_3_exonuc_N; pfam02739 1138877005889 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1138877005890 active site 1138877005891 metal binding site 1 [ion binding]; metal-binding site 1138877005892 putative 5' ssDNA interaction site; other site 1138877005893 metal binding site 3; metal-binding site 1138877005894 metal binding site 2 [ion binding]; metal-binding site 1138877005895 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1138877005896 putative DNA binding site [nucleotide binding]; other site 1138877005897 putative metal binding site [ion binding]; other site 1138877005898 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 1138877005899 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 1138877005900 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1138877005901 ATP binding site [chemical binding]; other site 1138877005902 putative Mg++ binding site [ion binding]; other site 1138877005903 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1138877005904 nucleotide binding region [chemical binding]; other site 1138877005905 ATP-binding site [chemical binding]; other site 1138877005906 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 1138877005907 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 1138877005908 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 1138877005909 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 1138877005910 Predicted transcriptional regulator [Transcription]; Region: COG2378 1138877005911 WYL domain; Region: WYL; pfam13280 1138877005912 Predicted transcriptional regulator [Transcription]; Region: COG2378 1138877005913 WYL domain; Region: WYL; pfam13280 1138877005914 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 1138877005915 PE family; Region: PE; pfam00934 1138877005916 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1138877005917 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1138877005918 active site 1138877005919 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 1138877005920 SNF2 Helicase protein; Region: DUF3670; pfam12419 1138877005921 Uncharacterized conserved protein [Function unknown]; Region: COG4279 1138877005922 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 1138877005923 putative active site [active] 1138877005924 PE family; Region: PE; pfam00934 1138877005925 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1138877005926 Transposase; Region: HTH_Tnp_1; cl17663 1138877005927 putative transposase OrfB; Reviewed; Region: PHA02517 1138877005928 HTH-like domain; Region: HTH_21; pfam13276 1138877005929 Integrase core domain; Region: rve; pfam00665 1138877005930 Integrase core domain; Region: rve_3; pfam13683 1138877005931 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138877005932 PPE family; Region: PPE; pfam00823 1138877005933 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 1138877005934 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 1138877005935 active site 1138877005936 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 1138877005937 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 1138877005938 active site 1138877005939 Pup-like protein; Region: Pup; pfam05639 1138877005940 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 1138877005941 proteasome ATPase; Region: pup_AAA; TIGR03689 1138877005942 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138877005943 Walker A motif; other site 1138877005944 ATP binding site [chemical binding]; other site 1138877005945 Walker B motif; other site 1138877005946 arginine finger; other site 1138877005947 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1138877005948 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1550 1138877005949 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 1138877005950 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138877005951 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 1138877005952 Predicted membrane protein [Function unknown]; Region: COG3918 1138877005953 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 1138877005954 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 1138877005955 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 1138877005956 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 1138877005957 homodimer interface [polypeptide binding]; other site 1138877005958 putative metal binding site [ion binding]; other site 1138877005959 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138877005960 PPE family; Region: PPE; pfam00823 1138877005961 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1138877005962 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 1138877005963 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 1138877005964 substrate binding pocket [chemical binding]; other site 1138877005965 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 1138877005966 B12 binding site [chemical binding]; other site 1138877005967 cobalt ligand [ion binding]; other site 1138877005968 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 1138877005969 PAC2 family; Region: PAC2; pfam09754 1138877005970 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1138877005971 short chain dehydrogenase; Provisional; Region: PRK05872 1138877005972 classical (c) SDRs; Region: SDR_c; cd05233 1138877005973 NAD(P) binding site [chemical binding]; other site 1138877005974 active site 1138877005975 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1138877005976 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 1138877005977 active site 1138877005978 HIGH motif; other site 1138877005979 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1138877005980 active site 1138877005981 KMSKS motif; other site 1138877005982 Anticodon-binding domain of cysteinyl tRNA synthetases and domain found in MshC; Region: Anticodon_Ia_Cys_like; cd07955 1138877005983 putative tRNA binding surface [nucleotide binding]; other site 1138877005984 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1138877005985 active site 1138877005986 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1138877005987 conserved hypothetical protein; Region: TIGR03843 1138877005988 conserved hypothetical protein; Region: TIGR03847 1138877005989 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1138877005990 catalytic core [active] 1138877005991 undecaprenyl-diphosphatase UppP; Region: undec_PP_bacA; TIGR00753 1138877005992 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1138877005993 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1138877005994 quinone interaction residues [chemical binding]; other site 1138877005995 active site 1138877005996 catalytic residues [active] 1138877005997 FMN binding site [chemical binding]; other site 1138877005998 substrate binding site [chemical binding]; other site 1138877005999 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1138877006000 substrate binding site [chemical binding]; other site 1138877006001 hypothetical protein; Provisional; Region: PRK07906 1138877006002 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 1138877006003 putative metal binding site [ion binding]; other site 1138877006004 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483 1138877006005 putative addiction module component, TIGR02574 family; Region: stabl_TIGR02574 1138877006006 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1138877006007 active site 1138877006008 DivIVA domain; Region: DivI1A_domain; TIGR03544 1138877006009 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 1138877006010 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1138877006011 Predicted integral membrane protein [Function unknown]; Region: COG0762 1138877006012 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 1138877006013 Predicted enzyme with a TIM-barrel fold [General function prediction only]; Region: COG0325 1138877006014 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1138877006015 catalytic residue [active] 1138877006016 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1138877006017 uncharacterized protein, YfiH family; Region: TIGR00726 1138877006018 cell division protein FtsZ; Validated; Region: PRK09330 1138877006019 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1138877006020 nucleotide binding site [chemical binding]; other site 1138877006021 SulA interaction site; other site 1138877006022 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 1138877006023 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1138877006024 Cell division protein FtsQ; Region: FtsQ; pfam03799 1138877006025 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1138877006026 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1138877006027 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1138877006028 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1138877006029 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1138877006030 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Region: murG; TIGR01133 1138877006031 active site 1138877006032 homodimer interface [polypeptide binding]; other site 1138877006033 cell division protein FtsW; Region: ftsW; TIGR02614 1138877006034 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03369 1138877006035 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1138877006036 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1138877006037 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1138877006038 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1138877006039 Mg++ binding site [ion binding]; other site 1138877006040 putative catalytic motif [active] 1138877006041 putative substrate binding site [chemical binding]; other site 1138877006042 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 1138877006043 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1138877006044 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1138877006045 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1138877006046 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1138877006047 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1138877006048 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1138877006049 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138877006050 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138877006051 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1138877006052 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1138877006053 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1138877006054 PE family; Region: PE; pfam00934 1138877006055 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1138877006056 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1138877006057 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1138877006058 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 1138877006059 MraW methylase family; Region: Methyltransf_5; pfam01795 1138877006060 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 1138877006061 MraZ protein; Region: MraZ; pfam02381 1138877006062 MraZ protein; Region: MraZ; pfam02381 1138877006063 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 1138877006064 Protein of unknown function (DUF3153); Region: DUF3153; pfam11353 1138877006065 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1138877006066 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1138877006067 substrate binding pocket [chemical binding]; other site 1138877006068 chain length determination region; other site 1138877006069 substrate-Mg2+ binding site; other site 1138877006070 catalytic residues [active] 1138877006071 aspartate-rich region 1; other site 1138877006072 active site lid residues [active] 1138877006073 aspartate-rich region 2; other site 1138877006074 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 1138877006075 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1138877006076 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1138877006077 active site 1138877006078 ATP binding site [chemical binding]; other site 1138877006079 substrate binding site [chemical binding]; other site 1138877006080 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1138877006081 substrate binding site [chemical binding]; other site 1138877006082 activation loop (A-loop); other site 1138877006083 activation loop (A-loop); other site 1138877006084 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1138877006085 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1138877006086 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; COG3200 1138877006087 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 1138877006088 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1138877006089 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1138877006090 putative acyl-acceptor binding pocket; other site 1138877006091 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 1138877006092 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1138877006093 DTAP/Switch II; other site 1138877006094 Switch I; other site 1138877006095 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1138877006096 putative hydrophobic ligand binding site [chemical binding]; other site 1138877006097 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1138877006098 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1138877006099 acyl-activating enzyme (AAE) consensus motif; other site 1138877006100 putative AMP binding site [chemical binding]; other site 1138877006101 putative active site [active] 1138877006102 putative CoA binding site [chemical binding]; other site 1138877006103 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1138877006104 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1138877006105 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 1138877006106 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1138877006107 NlpC/P60 family; Region: NLPC_P60; pfam00877 1138877006108 hypothetical protein; Validated; Region: PRK07883 1138877006109 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1138877006110 active site 1138877006111 catalytic site [active] 1138877006112 substrate binding site [chemical binding]; other site 1138877006113 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1138877006114 GIY-YIG motif/motif A; other site 1138877006115 active site 1138877006116 catalytic site [active] 1138877006117 putative DNA binding site [nucleotide binding]; other site 1138877006118 metal binding site [ion binding]; metal-binding site 1138877006119 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1138877006120 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1138877006121 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1138877006122 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 1138877006123 Subunit I/III interface [polypeptide binding]; other site 1138877006124 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1138877006125 Cytochrome c; Region: Cytochrom_C; pfam00034 1138877006126 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1138877006127 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1138877006128 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1138877006129 iron-sulfur cluster [ion binding]; other site 1138877006130 [2Fe-2S] cluster binding site [ion binding]; other site 1138877006131 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1138877006132 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 1138877006133 heme bH binding site [chemical binding]; other site 1138877006134 intrachain domain interface; other site 1138877006135 heme bL binding site [chemical binding]; other site 1138877006136 interchain domain interface [polypeptide binding]; other site 1138877006137 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 1138877006138 Qo binding site; other site 1138877006139 Protein of unknown function (DUF2561); Region: DUF2561; pfam10812 1138877006140 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1138877006141 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 1138877006142 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 1138877006143 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1138877006144 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 1138877006145 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1138877006146 dimer interface [polypeptide binding]; other site 1138877006147 active site 1138877006148 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1138877006149 Ligand Binding Site [chemical binding]; other site 1138877006150 Molecular Tunnel; other site 1138877006151 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 1138877006152 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1138877006153 substrate binding site [chemical binding]; other site 1138877006154 ATP binding site [chemical binding]; other site 1138877006155 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1138877006156 Glycerate kinase family; Region: Gly_kinase; pfam02595 1138877006157 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 1138877006158 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 1138877006159 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 1138877006160 putative dimer interface [polypeptide binding]; other site 1138877006161 active site pocket [active] 1138877006162 putative cataytic base [active] 1138877006163 Cobalamin-5-phosphate synthase; Region: CobS; pfam02654 1138877006164 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1138877006165 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1138877006166 homodimer interface [polypeptide binding]; other site 1138877006167 substrate-cofactor binding pocket; other site 1138877006168 catalytic residue [active] 1138877006169 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1138877006170 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1138877006171 cyclase homology domain; Region: CHD; cd07302 1138877006172 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1138877006173 nucleotidyl binding site; other site 1138877006174 metal binding site [ion binding]; metal-binding site 1138877006175 dimer interface [polypeptide binding]; other site 1138877006176 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1138877006177 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1138877006178 interface (dimer of trimers) [polypeptide binding]; other site 1138877006179 Substrate-binding/catalytic site; other site 1138877006180 Zn-binding sites [ion binding]; other site 1138877006181 short chain dehydrogenase; Validated; Region: PRK05855 1138877006182 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1138877006183 classical (c) SDRs; Region: SDR_c; cd05233 1138877006184 NAD(P) binding site [chemical binding]; other site 1138877006185 active site 1138877006186 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 1138877006187 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1138877006188 E3 interaction surface; other site 1138877006189 lipoyl attachment site [posttranslational modification]; other site 1138877006190 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1138877006191 E3 interaction surface; other site 1138877006192 lipoyl attachment site [posttranslational modification]; other site 1138877006193 e3 binding domain; Region: E3_binding; pfam02817 1138877006194 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1138877006195 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 1138877006196 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 1138877006197 putative NAD(P) binding site [chemical binding]; other site 1138877006198 putative active site [active] 1138877006199 lipoate-protein ligase B; Provisional; Region: PRK14345 1138877006200 lipoyl synthase; Provisional; Region: PRK05481 1138877006201 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1138877006202 FeS/SAM binding site; other site 1138877006203 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 1138877006204 RDD family; Region: RDD; pfam06271 1138877006205 glutamine synthetase, type I; Region: GlnA; TIGR00653 1138877006206 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1138877006207 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1138877006208 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 1138877006209 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1138877006210 metal binding triad; other site 1138877006211 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1138877006212 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1138877006213 metal binding triad; other site 1138877006214 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1138877006215 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1138877006216 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1138877006217 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1138877006218 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1138877006219 TAP-like protein; Region: Abhydrolase_4; pfam08386 1138877006220 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1138877006221 TAP-like protein; Region: Abhydrolase_4; pfam08386 1138877006222 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1138877006223 oligomerization interface [polypeptide binding]; other site 1138877006224 active site 1138877006225 metal binding site [ion binding]; metal-binding site 1138877006226 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 1138877006227 putative active site; other site 1138877006228 putative metal binding residues [ion binding]; other site 1138877006229 signature motif; other site 1138877006230 putative triphosphate binding site [ion binding]; other site 1138877006231 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 1138877006232 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3826 1138877006233 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 1138877006234 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1138877006235 RNA/DNA hybrid binding site [nucleotide binding]; other site 1138877006236 active site 1138877006237 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1138877006238 catalytic core [active] 1138877006239 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 1138877006240 Putative zinc ribbon domain; Region: DUF164; pfam02591 1138877006241 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 1138877006242 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 1138877006243 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1138877006244 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1138877006245 hypothetical protein; Provisional; Region: PRK07908 1138877006246 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1138877006247 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138877006248 homodimer interface [polypeptide binding]; other site 1138877006249 catalytic residue [active] 1138877006250 PIN domain nuclease, a component of toxin-antitoxin system (PIN domain) [Signal transduction mechanisms]; Region: COG3744 1138877006251 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1138877006252 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1138877006253 active site 1138877006254 motif I; other site 1138877006255 motif II; other site 1138877006256 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1138877006257 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1138877006258 active site 1138877006259 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 1138877006260 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 1138877006261 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 1138877006262 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1138877006263 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 1138877006264 dimer interface [polypeptide binding]; other site 1138877006265 catalytic triad [active] 1138877006266 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 1138877006267 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 1138877006268 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1138877006269 dimer interface [polypeptide binding]; other site 1138877006270 TPP-binding site [chemical binding]; other site 1138877006271 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1138877006272 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1138877006273 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1138877006274 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1138877006275 acyl carrier protein; Provisional; Region: acpP; PRK00982 1138877006276 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 1138877006277 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1138877006278 dimer interface [polypeptide binding]; other site 1138877006279 active site 1138877006280 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 1138877006281 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1138877006282 dimer interface [polypeptide binding]; other site 1138877006283 active site 1138877006284 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1138877006285 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1138877006286 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1138877006287 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1138877006288 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1138877006289 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138877006290 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138877006291 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1138877006292 FAD binding domain; Region: FAD_binding_4; pfam01565 1138877006293 diacylglycerol kinase; Reviewed; Region: PRK11914 1138877006294 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1138877006295 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 1138877006296 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1138877006297 Beta-lactamase; Region: Beta-lactamase; pfam00144 1138877006298 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1138877006299 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138877006300 S-adenosylmethionine binding site [chemical binding]; other site 1138877006301 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 1138877006302 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1138877006303 NAD binding site [chemical binding]; other site 1138877006304 catalytic Zn binding site [ion binding]; other site 1138877006305 substrate binding site [chemical binding]; other site 1138877006306 structural Zn binding site [ion binding]; other site 1138877006307 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1138877006308 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 1138877006309 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1138877006310 putative active site [active] 1138877006311 catalytic triad [active] 1138877006312 putative dimer interface [polypeptide binding]; other site 1138877006313 short chain dehydrogenase; Provisional; Region: PRK05854 1138877006314 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 1138877006315 putative NAD(P) binding site [chemical binding]; other site 1138877006316 active site 1138877006317 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 1138877006318 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1138877006319 nucleotide binding site [chemical binding]; other site 1138877006320 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1138877006321 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138877006322 Cytochrome P450; Region: p450; cl12078 1138877006323 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 1138877006324 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138877006325 Cytochrome P450; Region: p450; cl12078 1138877006326 Septum formation; Region: Septum_form; pfam13845 1138877006327 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 1138877006328 FAD binding domain; Region: FAD_binding_4; pfam01565 1138877006329 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1138877006330 putative transposase OrfB; Reviewed; Region: PHA02517 1138877006331 HTH-like domain; Region: HTH_21; pfam13276 1138877006332 Integrase core domain; Region: rve; pfam00665 1138877006333 Integrase core domain; Region: rve_3; pfam13683 1138877006334 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1138877006335 Transposase; Region: HTH_Tnp_1; cl17663 1138877006336 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1138877006337 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1138877006338 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1138877006339 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1138877006340 dimerization interface [polypeptide binding]; other site 1138877006341 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1138877006342 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1138877006343 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1138877006344 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1138877006345 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1138877006346 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1138877006347 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1138877006348 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 1138877006349 CDP-diacylglycerol pyrophosphatase; Region: CDH; cl00934 1138877006350 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1138877006351 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1138877006352 active site residue [active] 1138877006353 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1138877006354 active site residue [active] 1138877006355 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1138877006356 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 1138877006357 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1138877006358 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1138877006359 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138877006360 homodimer interface [polypeptide binding]; other site 1138877006361 catalytic residue [active] 1138877006362 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3196 1138877006363 haloalkane dehalogenase; Provisional; Region: PRK00870 1138877006364 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1138877006365 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1138877006366 active site 1138877006367 catalytic tetrad [active] 1138877006368 heat shock protein 90; Provisional; Region: PRK05218 1138877006369 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1138877006370 ATP binding site [chemical binding]; other site 1138877006371 Mg2+ binding site [ion binding]; other site 1138877006372 G-X-G motif; other site 1138877006373 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1138877006374 Cutinase; Region: Cutinase; pfam01083 1138877006375 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 1138877006376 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 1138877006377 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 1138877006378 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1138877006379 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1138877006380 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1138877006381 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1138877006382 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1138877006383 Uncharacterized conserved protein [Function unknown]; Region: COG2442 1138877006384 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1138877006385 DNA binding site [nucleotide binding] 1138877006386 active site 1138877006387 Int/Topo IB signature motif; other site 1138877006388 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 1138877006389 DNA binding residues [nucleotide binding] 1138877006390 Family description; Region: UvrD_C_2; pfam13538 1138877006391 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1138877006392 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1138877006393 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1138877006394 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1138877006395 putative PBP binding loops; other site 1138877006396 ABC-ATPase subunit interface; other site 1138877006397 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1138877006398 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1138877006399 dimer interface [polypeptide binding]; other site 1138877006400 conserved gate region; other site 1138877006401 putative PBP binding loops; other site 1138877006402 ABC-ATPase subunit interface; other site 1138877006403 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1138877006404 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1138877006405 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1138877006406 Ligand Binding Site [chemical binding]; other site 1138877006407 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1138877006408 Ligand Binding Site [chemical binding]; other site 1138877006409 amino acid transporter; Region: 2A0306; TIGR00909 1138877006410 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1138877006411 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 1138877006412 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1138877006413 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1138877006414 catalytic residue [active] 1138877006415 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1138877006416 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1138877006417 Amidinotransferase; Region: Amidinotransf; pfam02274 1138877006418 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 1138877006419 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1138877006420 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1138877006421 putative DNA binding site [nucleotide binding]; other site 1138877006422 putative Zn2+ binding site [ion binding]; other site 1138877006423 AsnC family; Region: AsnC_trans_reg; pfam01037 1138877006424 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1138877006425 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1138877006426 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 1138877006427 Walker A/P-loop; other site 1138877006428 ATP binding site [chemical binding]; other site 1138877006429 Q-loop/lid; other site 1138877006430 ABC transporter signature motif; other site 1138877006431 Walker B; other site 1138877006432 D-loop; other site 1138877006433 H-loop/switch region; other site 1138877006434 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1138877006435 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1138877006436 Walker A/P-loop; other site 1138877006437 ATP binding site [chemical binding]; other site 1138877006438 Q-loop/lid; other site 1138877006439 ABC transporter signature motif; other site 1138877006440 Walker B; other site 1138877006441 D-loop; other site 1138877006442 H-loop/switch region; other site 1138877006443 MarR family; Region: MarR; pfam01047 1138877006444 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1138877006445 PE family; Region: PE; pfam00934 1138877006446 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1138877006447 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138877006448 putative substrate translocation pore; other site 1138877006449 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 1138877006450 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1138877006451 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1138877006452 malate dehydrogenase; Provisional; Region: PRK13529 1138877006453 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1138877006454 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1138877006455 NAD(P) binding site [chemical binding]; other site 1138877006456 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138877006457 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1138877006458 putative substrate translocation pore; other site 1138877006459 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138877006460 putative substrate translocation pore; other site 1138877006461 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1138877006462 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1138877006463 dimer interface [polypeptide binding]; other site 1138877006464 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138877006465 catalytic residue [active] 1138877006466 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 1138877006467 serine O-acetyltransferase; Region: cysE; TIGR01172 1138877006468 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1138877006469 trimer interface [polypeptide binding]; other site 1138877006470 active site 1138877006471 substrate binding site [chemical binding]; other site 1138877006472 CoA binding site [chemical binding]; other site 1138877006473 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1138877006474 Transposase; Region: HTH_Tnp_1; cl17663 1138877006475 putative transposase OrfB; Reviewed; Region: PHA02517 1138877006476 HTH-like domain; Region: HTH_21; pfam13276 1138877006477 Integrase core domain; Region: rve; pfam00665 1138877006478 Integrase core domain; Region: rve_3; pfam13683 1138877006479 hypothetical protein; Provisional; Region: PRK14851 1138877006480 hypothetical protein; Validated; Region: PRK08223 1138877006481 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 1138877006482 ATP binding site [chemical binding]; other site 1138877006483 substrate interface [chemical binding]; other site 1138877006484 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1138877006485 PE family; Region: PE; pfam00934 1138877006486 DNA primase; Validated; Region: dnaG; PRK05667 1138877006487 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1138877006488 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1138877006489 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1138877006490 active site 1138877006491 metal binding site [ion binding]; metal-binding site 1138877006492 interdomain interaction site; other site 1138877006493 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1138877006494 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 1138877006495 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 1138877006496 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1138877006497 Zn2+ binding site [ion binding]; other site 1138877006498 Mg2+ binding site [ion binding]; other site 1138877006499 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1138877006500 Repair protein; Region: Repair_PSII; pfam04536 1138877006501 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1138877006502 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1138877006503 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 1138877006504 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1138877006505 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 1138877006506 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1138877006507 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 1138877006508 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1138877006509 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138877006510 PPE family; Region: PPE; pfam00823 1138877006511 PPE family; Region: PPE; pfam00823 1138877006512 PPE family; Region: PPE; pfam00823 1138877006513 glycyl-tRNA synthetase; Provisional; Region: PRK04173 1138877006514 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1138877006515 motif 1; other site 1138877006516 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 1138877006517 active site 1138877006518 motif 2; other site 1138877006519 motif 3; other site 1138877006520 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 1138877006521 anticodon binding site; other site 1138877006522 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1138877006523 dimerization interface [polypeptide binding]; other site 1138877006524 putative DNA binding site [nucleotide binding]; other site 1138877006525 putative Zn2+ binding site [ion binding]; other site 1138877006526 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1138877006527 metal binding site 2 [ion binding]; metal-binding site 1138877006528 putative DNA binding helix; other site 1138877006529 metal binding site 1 [ion binding]; metal-binding site 1138877006530 dimer interface [polypeptide binding]; other site 1138877006531 structural Zn2+ binding site [ion binding]; other site 1138877006532 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1138877006533 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1138877006534 catalytic residue [active] 1138877006535 putative FPP diphosphate binding site; other site 1138877006536 putative FPP binding hydrophobic cleft; other site 1138877006537 dimer interface [polypeptide binding]; other site 1138877006538 putative IPP diphosphate binding site; other site 1138877006539 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1138877006540 Recombination protein O N terminal; Region: RecO_N; pfam11967 1138877006541 Recombination protein O C terminal; Region: RecO_C; pfam02565 1138877006542 amidase; Provisional; Region: PRK06061 1138877006543 Amidase; Region: Amidase; pfam01425 1138877006544 GTPase Era; Reviewed; Region: era; PRK00089 1138877006545 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1138877006546 G1 box; other site 1138877006547 GTP/Mg2+ binding site [chemical binding]; other site 1138877006548 Switch I region; other site 1138877006549 G2 box; other site 1138877006550 Switch II region; other site 1138877006551 G3 box; other site 1138877006552 G4 box; other site 1138877006553 G5 box; other site 1138877006554 KH domain; Region: KH_2; pfam07650 1138877006555 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1138877006556 Domain of unknown function DUF21; Region: DUF21; pfam01595 1138877006557 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1138877006558 Transporter associated domain; Region: CorC_HlyC; smart01091 1138877006559 metal-binding heat shock protein; Provisional; Region: PRK00016 1138877006560 K homology RNA-binding domain; Region: KH; smart00322 1138877006561 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1138877006562 PhoH-like protein; Region: PhoH; pfam02562 1138877006563 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1138877006564 PE family; Region: PE; pfam00934 1138877006565 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 1138877006566 RNA methyltransferase, RsmE family; Region: TIGR00046 1138877006567 chaperone protein DnaJ; Provisional; Region: PRK14278 1138877006568 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1138877006569 HSP70 interaction site [polypeptide binding]; other site 1138877006570 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1138877006571 Zn binding sites [ion binding]; other site 1138877006572 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1138877006573 dimer interface [polypeptide binding]; other site 1138877006574 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1138877006575 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 1138877006576 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 1138877006577 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1138877006578 Condensation domain; Region: Condensation; pfam00668 1138877006579 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1138877006580 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1138877006581 acyl-activating enzyme (AAE) consensus motif; other site 1138877006582 AMP binding site [chemical binding]; other site 1138877006583 Condensation domain; Region: Condensation; pfam00668 1138877006584 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1138877006585 Condensation domain; Region: Condensation; pfam00668 1138877006586 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1138877006587 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1138877006588 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1138877006589 acyl-activating enzyme (AAE) consensus motif; other site 1138877006590 AMP binding site [chemical binding]; other site 1138877006591 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138877006592 Condensation domain; Region: Condensation; pfam00668 1138877006593 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1138877006594 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1138877006595 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138877006596 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138877006597 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1138877006598 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1138877006599 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 1138877006600 NADP binding site [chemical binding]; other site 1138877006601 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1138877006602 active site 1138877006603 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1138877006604 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1138877006605 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1138877006606 active site 1138877006607 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 1138877006608 Condensation domain; Region: Condensation; pfam00668 1138877006609 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1138877006610 Nonribosomal peptide synthase; Region: NRPS; pfam08415 1138877006611 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 1138877006612 acyl-activating enzyme (AAE) consensus motif; other site 1138877006613 AMP binding site [chemical binding]; other site 1138877006614 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138877006615 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1138877006616 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 1138877006617 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 1138877006618 acyl-activating enzyme (AAE) consensus motif; other site 1138877006619 active site 1138877006620 AMP binding site [chemical binding]; other site 1138877006621 substrate binding site [chemical binding]; other site 1138877006622 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1138877006623 salicylate synthase MbtI; Reviewed; Region: PRK07912 1138877006624 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1138877006625 Predicted permease [General function prediction only]; Region: COG3329 1138877006626 coproporphyrinogen III oxidase; Validated; Region: PRK05628 1138877006627 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1138877006628 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 1138877006629 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1138877006630 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1138877006631 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1138877006632 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1138877006633 Active Sites [active] 1138877006634 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1138877006635 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1138877006636 putative active site [active] 1138877006637 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 1138877006638 putative active site [active] 1138877006639 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1138877006640 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1138877006641 Predicted membrane protein [Function unknown]; Region: COG1297 1138877006642 putative oligopeptide transporter, OPT family; Region: TIGR00733 1138877006643 PE family; Region: PE; pfam00934 1138877006644 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 1138877006645 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 1138877006646 Walker A/P-loop; other site 1138877006647 ATP binding site [chemical binding]; other site 1138877006648 Q-loop/lid; other site 1138877006649 ABC transporter signature motif; other site 1138877006650 Walker B; other site 1138877006651 D-loop; other site 1138877006652 H-loop/switch region; other site 1138877006653 sulfate transport protein; Provisional; Region: cysT; CHL00187 1138877006654 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1138877006655 dimer interface [polypeptide binding]; other site 1138877006656 conserved gate region; other site 1138877006657 putative PBP binding loops; other site 1138877006658 ABC-ATPase subunit interface; other site 1138877006659 sulfate transport protein; Provisional; Region: cysT; CHL00187 1138877006660 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1138877006661 dimer interface [polypeptide binding]; other site 1138877006662 conserved gate region; other site 1138877006663 putative PBP binding loops; other site 1138877006664 ABC-ATPase subunit interface; other site 1138877006665 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 1138877006666 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1138877006667 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 1138877006668 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1138877006669 PknH-like extracellular domain; Region: PknH_C; pfam14032 1138877006670 GTP-binding protein LepA; Provisional; Region: PRK05433 1138877006671 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1138877006672 G1 box; other site 1138877006673 putative GEF interaction site [polypeptide binding]; other site 1138877006674 GTP/Mg2+ binding site [chemical binding]; other site 1138877006675 Switch I region; other site 1138877006676 G2 box; other site 1138877006677 G3 box; other site 1138877006678 Switch II region; other site 1138877006679 G4 box; other site 1138877006680 G5 box; other site 1138877006681 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1138877006682 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1138877006683 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1138877006684 PemK-like protein; Region: PemK; pfam02452 1138877006685 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 1138877006686 FOG: CBS domain [General function prediction only]; Region: COG0517 1138877006687 ribonuclease Z; Reviewed; Region: PRK00055 1138877006688 PE family; Region: PE; pfam00934 1138877006689 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1138877006690 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1138877006691 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1138877006692 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 1138877006693 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 1138877006694 Uncharacterized conserved protein [Function unknown]; Region: COG2308 1138877006695 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1138877006696 hypothetical protein; Reviewed; Region: PRK07914 1138877006697 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1138877006698 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 1138877006699 Competence protein; Region: Competence; pfam03772 1138877006700 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 1138877006701 Helix-hairpin-helix motif; Region: HHH; pfam00633 1138877006702 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 1138877006703 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1138877006704 Coenzyme A binding pocket [chemical binding]; other site 1138877006705 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307 1138877006706 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1138877006707 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1138877006708 active site 1138877006709 catalytic triad [active] 1138877006710 oxyanion hole [active] 1138877006711 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1138877006712 catalytic core [active] 1138877006713 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 1138877006714 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1138877006715 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1138877006716 active site 1138877006717 (T/H)XGH motif; other site 1138877006718 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1138877006719 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138877006720 S-adenosylmethionine binding site [chemical binding]; other site 1138877006721 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1138877006722 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1138877006723 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1138877006724 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 1138877006725 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1138877006726 metal ion-dependent adhesion site (MIDAS); other site 1138877006727 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1138877006728 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138877006729 Walker A motif; other site 1138877006730 ATP binding site [chemical binding]; other site 1138877006731 Walker B motif; other site 1138877006732 arginine finger; other site 1138877006733 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1138877006734 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1138877006735 putative catalytic cysteine [active] 1138877006736 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1138877006737 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1138877006738 dimer interface [polypeptide binding]; other site 1138877006739 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1138877006740 catalytic triad [active] 1138877006741 peroxidatic and resolving cysteines [active] 1138877006742 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 1138877006743 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 1138877006744 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138877006745 PPE family; Region: PPE; pfam00823 1138877006746 PE family; Region: PE; pfam00934 1138877006747 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1138877006748 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1138877006749 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1138877006750 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1138877006751 ligand binding site [chemical binding]; other site 1138877006752 flexible hinge region; other site 1138877006753 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1138877006754 dimerization interface [polypeptide binding]; other site 1138877006755 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 1138877006756 cyclase homology domain; Region: CHD; cd07302 1138877006757 nucleotidyl binding site; other site 1138877006758 metal binding site [ion binding]; metal-binding site 1138877006759 dimer interface [polypeptide binding]; other site 1138877006760 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1138877006761 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1138877006762 substrate binding site [chemical binding]; other site 1138877006763 dimer interface [polypeptide binding]; other site 1138877006764 ATP binding site [chemical binding]; other site 1138877006765 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1138877006766 NAD synthetase; Reviewed; Region: nadE; PRK02628 1138877006767 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 1138877006768 multimer interface [polypeptide binding]; other site 1138877006769 active site 1138877006770 catalytic triad [active] 1138877006771 protein interface 1 [polypeptide binding]; other site 1138877006772 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1138877006773 homodimer interface [polypeptide binding]; other site 1138877006774 NAD binding pocket [chemical binding]; other site 1138877006775 ATP binding pocket [chemical binding]; other site 1138877006776 Mg binding site [ion binding]; other site 1138877006777 active-site loop [active] 1138877006778 gamma-glutamyl kinase; Provisional; Region: PRK05429 1138877006779 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1138877006780 nucleotide binding site [chemical binding]; other site 1138877006781 homotetrameric interface [polypeptide binding]; other site 1138877006782 putative phosphate binding site [ion binding]; other site 1138877006783 putative allosteric binding site; other site 1138877006784 PUA domain; Region: PUA; pfam01472 1138877006785 GTPase CgtA; Reviewed; Region: obgE; PRK12296 1138877006786 GTP1/OBG; Region: GTP1_OBG; pfam01018 1138877006787 Obg GTPase; Region: Obg; cd01898 1138877006788 G1 box; other site 1138877006789 GTP/Mg2+ binding site [chemical binding]; other site 1138877006790 Switch I region; other site 1138877006791 G2 box; other site 1138877006792 G3 box; other site 1138877006793 Switch II region; other site 1138877006794 G4 box; other site 1138877006795 G5 box; other site 1138877006796 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1138877006797 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1138877006798 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1138877006799 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1138877006800 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1138877006801 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 1138877006802 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1138877006803 homodimer interface [polypeptide binding]; other site 1138877006804 oligonucleotide binding site [chemical binding]; other site 1138877006805 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1138877006806 active site 1138877006807 multimer interface [polypeptide binding]; other site 1138877006808 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 1138877006809 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1138877006810 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1138877006811 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1138877006812 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1138877006813 active site 1138877006814 HIGH motif; other site 1138877006815 nucleotide binding site [chemical binding]; other site 1138877006816 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1138877006817 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1138877006818 active site 1138877006819 KMSKS motif; other site 1138877006820 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1138877006821 tRNA binding surface [nucleotide binding]; other site 1138877006822 anticodon binding site; other site 1138877006823 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1138877006824 Uncharacterized conserved protein [Function unknown]; Region: COG3268 1138877006825 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 1138877006826 NAD(P) binding pocket [chemical binding]; other site 1138877006827 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1138877006828 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1138877006829 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1138877006830 GTP binding site; other site 1138877006831 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 1138877006832 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 1138877006833 TPP-binding site [chemical binding]; other site 1138877006834 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1138877006835 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 1138877006836 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1138877006837 dimer interface [polypeptide binding]; other site 1138877006838 PYR/PP interface [polypeptide binding]; other site 1138877006839 TPP binding site [chemical binding]; other site 1138877006840 substrate binding site [chemical binding]; other site 1138877006841 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1138877006842 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1138877006843 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138877006844 Walker A motif; other site 1138877006845 ATP binding site [chemical binding]; other site 1138877006846 Walker B motif; other site 1138877006847 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1138877006848 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 1138877006849 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 1138877006850 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138877006851 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1138877006852 putative substrate translocation pore; other site 1138877006853 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138877006854 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 1138877006855 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1138877006856 oligomer interface [polypeptide binding]; other site 1138877006857 active site residues [active] 1138877006858 Clp protease; Region: CLP_protease; pfam00574 1138877006859 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1138877006860 oligomer interface [polypeptide binding]; other site 1138877006861 active site residues [active] 1138877006862 trigger factor; Provisional; Region: tig; PRK01490 1138877006863 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1138877006864 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1138877006865 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1138877006866 Beta-lactamase; Region: Beta-lactamase; pfam00144 1138877006867 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1138877006868 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 1138877006869 putative DNA binding site [nucleotide binding]; other site 1138877006870 catalytic residue [active] 1138877006871 putative H2TH interface [polypeptide binding]; other site 1138877006872 putative catalytic residues [active] 1138877006873 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1138877006874 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1138877006875 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 1138877006876 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1138877006877 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1138877006878 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 1138877006879 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 1138877006880 Zn binding site [ion binding]; other site 1138877006881 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1138877006882 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1138877006883 active site 1138877006884 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1138877006885 apolar tunnel; other site 1138877006886 heme binding site [chemical binding]; other site 1138877006887 dimerization interface [polypeptide binding]; other site 1138877006888 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 1138877006889 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1138877006890 active site 1138877006891 catalytic site [active] 1138877006892 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1138877006893 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1138877006894 active site 1138877006895 NAD-specific glutamate dehydrogenase [Amino acid transport and metabolism]; Region: COG2902 1138877006896 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1138877006897 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1138877006898 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1138877006899 ABC transporter; Region: ABC_tran_2; pfam12848 1138877006900 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1138877006901 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1138877006902 dimer interface [polypeptide binding]; other site 1138877006903 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1138877006904 ssDNA binding site [nucleotide binding]; other site 1138877006905 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1138877006906 glycerol-3-phosphate acyltransferase; Validated; Region: PRK03355 1138877006907 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 1138877006908 putative acyl-acceptor binding pocket; other site 1138877006909 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1138877006910 HAD-superfamily subfamily IB hydrolase, TIGR01490; Region: HAD-SF-IB-hyp1 1138877006911 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1138877006912 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1138877006913 putative acyl-acceptor binding pocket; other site 1138877006914 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1138877006915 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1138877006916 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1138877006917 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1138877006918 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1138877006919 enoyl-CoA hydratase; Provisional; Region: PRK05870 1138877006920 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138877006921 substrate binding site [chemical binding]; other site 1138877006922 oxyanion hole (OAH) forming residues; other site 1138877006923 trimer interface [polypeptide binding]; other site 1138877006924 PE family; Region: PE; pfam00934 1138877006925 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1138877006926 cyclase homology domain; Region: CHD; cd07302 1138877006927 nucleotidyl binding site; other site 1138877006928 metal binding site [ion binding]; metal-binding site 1138877006929 dimer interface [polypeptide binding]; other site 1138877006930 Predicted ATPase [General function prediction only]; Region: COG3903 1138877006931 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1138877006932 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1138877006933 DNA binding residues [nucleotide binding] 1138877006934 dimerization interface [polypeptide binding]; other site 1138877006935 PE family; Region: PE; pfam00934 1138877006936 TIGR00725 family protein; Region: TIGR00725 1138877006937 thymidylate synthase; Provisional; Region: thyA; PRK00956 1138877006938 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 1138877006939 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1138877006940 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1138877006941 E3 interaction surface; other site 1138877006942 lipoyl attachment site [posttranslational modification]; other site 1138877006943 e3 binding domain; Region: E3_binding; pfam02817 1138877006944 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1138877006945 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1138877006946 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1138877006947 alpha subunit interface [polypeptide binding]; other site 1138877006948 TPP binding site [chemical binding]; other site 1138877006949 heterodimer interface [polypeptide binding]; other site 1138877006950 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1138877006951 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1138877006952 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1138877006953 tetramer interface [polypeptide binding]; other site 1138877006954 TPP-binding site [chemical binding]; other site 1138877006955 heterodimer interface [polypeptide binding]; other site 1138877006956 phosphorylation loop region [posttranslational modification] 1138877006957 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1138877006958 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 1138877006959 putative active site [active] 1138877006960 putative catalytic site [active] 1138877006961 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138877006962 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138877006963 active site 1138877006964 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1138877006965 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1138877006966 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1138877006967 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1138877006968 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1138877006969 carboxyltransferase (CT) interaction site; other site 1138877006970 biotinylation site [posttranslational modification]; other site 1138877006971 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1138877006972 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1138877006973 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1138877006974 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1138877006975 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1138877006976 AMP-binding domain protein; Validated; Region: PRK08315 1138877006977 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138877006978 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 1138877006979 acyl-activating enzyme (AAE) consensus motif; other site 1138877006980 acyl-activating enzyme (AAE) consensus motif; other site 1138877006981 putative AMP binding site [chemical binding]; other site 1138877006982 putative active site [active] 1138877006983 putative CoA binding site [chemical binding]; other site 1138877006984 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138877006985 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138877006986 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 1138877006987 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1138877006988 classical (c) SDRs; Region: SDR_c; cd05233 1138877006989 NAD(P) binding site [chemical binding]; other site 1138877006990 active site 1138877006991 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 1138877006992 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 1138877006993 catalytic site [active] 1138877006994 putative active site [active] 1138877006995 putative substrate binding site [chemical binding]; other site 1138877006996 dimer interface [polypeptide binding]; other site 1138877006997 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1138877006998 MULE transposase domain; Region: MULE; pfam10551 1138877006999 Domain of unknown function (DUF4411); Region: DUF4411; pfam14367 1138877007000 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1138877007001 non-specific DNA binding site [nucleotide binding]; other site 1138877007002 salt bridge; other site 1138877007003 sequence-specific DNA binding site [nucleotide binding]; other site 1138877007004 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 1138877007005 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2739; cl17893 1138877007006 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 1138877007007 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 1138877007008 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1138877007009 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1138877007010 PE family; Region: PE; pfam00934 1138877007011 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 1138877007012 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1138877007013 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1138877007014 catalytic triad [active] 1138877007015 hypothetical protein; Provisional; Region: PRK07907 1138877007016 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 1138877007017 active site 1138877007018 metal binding site [ion binding]; metal-binding site 1138877007019 dimer interface [polypeptide binding]; other site 1138877007020 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1138877007021 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1138877007022 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 1138877007023 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1138877007024 phosphate binding site [ion binding]; other site 1138877007025 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 1138877007026 FAS_MaoC, the MaoC-like hot dog fold of the fatty acid synthase, beta subunit. Other enzymes with this fold include MaoC dehydratase, Hydratase-Dehydrogenase-Epimerase protein (HDE), and 17-beta-hydroxysteriod dehydrogenase (HSD); Region: FAS_MaoC; cd03447 1138877007027 putative active site [active] 1138877007028 putative catalytic site [active] 1138877007029 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1138877007030 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1138877007031 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 1138877007032 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 1138877007033 putative NAD(P) binding site [chemical binding]; other site 1138877007034 active site 1138877007035 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 1138877007036 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1138877007037 active site 1138877007038 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 1138877007039 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 1138877007040 putative active site [active] 1138877007041 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 1138877007042 Mrr N-terminal domain; Region: Mrr_N; pfam14338 1138877007043 Restriction endonuclease; Region: Mrr_cat; pfam04471 1138877007044 ERCC4 domain; Region: ERCC4; pfam02732 1138877007045 Lsr2; Region: Lsr2; pfam11774 1138877007046 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 1138877007047 putative active site [active] 1138877007048 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1138877007049 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1138877007050 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1138877007051 catalytic residue [active] 1138877007052 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1138877007053 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 1138877007054 putative RNA binding site [nucleotide binding]; other site 1138877007055 elongation factor P; Validated; Region: PRK00529 1138877007056 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1138877007057 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1138877007058 RNA binding site [nucleotide binding]; other site 1138877007059 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1138877007060 RNA binding site [nucleotide binding]; other site 1138877007061 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1138877007062 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1138877007063 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1138877007064 active site 1138877007065 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1138877007066 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1138877007067 trimer interface [polypeptide binding]; other site 1138877007068 active site 1138877007069 dimer interface [polypeptide binding]; other site 1138877007070 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1138877007071 active site 1138877007072 dimer interface [polypeptide binding]; other site 1138877007073 metal binding site [ion binding]; metal-binding site 1138877007074 shikimate kinase; Reviewed; Region: aroK; PRK00131 1138877007075 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1138877007076 ADP binding site [chemical binding]; other site 1138877007077 magnesium binding site [ion binding]; other site 1138877007078 putative shikimate binding site; other site 1138877007079 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1138877007080 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1138877007081 Tetramer interface [polypeptide binding]; other site 1138877007082 active site 1138877007083 FMN-binding site [chemical binding]; other site 1138877007084 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 1138877007085 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 1138877007086 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 1138877007087 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 1138877007088 putative active site [active] 1138877007089 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1138877007090 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1138877007091 oligomeric interface; other site 1138877007092 putative active site [active] 1138877007093 homodimer interface [polypeptide binding]; other site 1138877007094 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2402 1138877007095 putative active site [active] 1138877007096 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1138877007097 shikimate-5-dehydrogenase, fungal AROM-type; Region: Shik-DH-AROM; TIGR01809 1138877007098 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1138877007099 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1138877007100 NAD(P) binding site [chemical binding]; other site 1138877007101 shikimate binding site; other site 1138877007102 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 1138877007103 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1138877007104 dimerization interface [polypeptide binding]; other site 1138877007105 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1138877007106 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1138877007107 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1138877007108 motif 1; other site 1138877007109 active site 1138877007110 motif 2; other site 1138877007111 motif 3; other site 1138877007112 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1138877007113 DHHA1 domain; Region: DHHA1; pfam02272 1138877007114 Uncharacterized conserved protein [Function unknown]; Region: COG0432 1138877007115 recombination factor protein RarA; Reviewed; Region: PRK13342 1138877007116 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138877007117 Walker A motif; other site 1138877007118 ATP binding site [chemical binding]; other site 1138877007119 Walker B motif; other site 1138877007120 arginine finger; other site 1138877007121 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1138877007122 Predicted integral membrane protein [Function unknown]; Region: COG5473 1138877007123 Protein of unknown function (DUF2652); Region: DUF2652; pfam10851 1138877007124 Protein of unknown function (DUF2652); Region: DUF2652; pfam10851 1138877007125 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1138877007126 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1138877007127 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1138877007128 Walker A/P-loop; other site 1138877007129 ATP binding site [chemical binding]; other site 1138877007130 Q-loop/lid; other site 1138877007131 ABC transporter signature motif; other site 1138877007132 Walker B; other site 1138877007133 D-loop; other site 1138877007134 H-loop/switch region; other site 1138877007135 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1138877007136 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1138877007137 ligand binding site [chemical binding]; other site 1138877007138 flexible hinge region; other site 1138877007139 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1138877007140 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1138877007141 ligand binding site [chemical binding]; other site 1138877007142 flexible hinge region; other site 1138877007143 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1138877007144 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 1138877007145 active site 1138877007146 nucleophile elbow; other site 1138877007147 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1138877007148 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1138877007149 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1138877007150 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 1138877007151 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 1138877007152 Uncharacterized conserved protein [Function unknown]; Region: COG2308 1138877007153 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 1138877007154 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 1138877007155 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307 1138877007156 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 1138877007157 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1138877007158 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1138877007159 Transglutaminase/protease-like homologues; Region: TGc; smart00460 1138877007160 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3801 1138877007161 Predicted membrane protein [Function unknown]; Region: COG4129 1138877007162 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1138877007163 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1138877007164 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1138877007165 dimer interface [polypeptide binding]; other site 1138877007166 anticodon binding site; other site 1138877007167 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1138877007168 homodimer interface [polypeptide binding]; other site 1138877007169 motif 1; other site 1138877007170 active site 1138877007171 motif 2; other site 1138877007172 GAD domain; Region: GAD; pfam02938 1138877007173 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1138877007174 active site 1138877007175 motif 3; other site 1138877007176 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 1138877007177 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1138877007178 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1138877007179 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 1138877007180 putative hydrophobic ligand binding site [chemical binding]; other site 1138877007181 protein interface [polypeptide binding]; other site 1138877007182 gate; other site 1138877007183 Predicted metalloprotease [General function prediction only]; Region: COG2321 1138877007184 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1138877007185 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 1138877007186 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1138877007187 active site 1138877007188 metal binding site [ion binding]; metal-binding site 1138877007189 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 1138877007190 haloalkane dehalogenase; Provisional; Region: PRK03592 1138877007191 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1138877007192 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1138877007193 dimer interface [polypeptide binding]; other site 1138877007194 motif 1; other site 1138877007195 active site 1138877007196 motif 2; other site 1138877007197 motif 3; other site 1138877007198 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1138877007199 anticodon binding site; other site 1138877007200 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1138877007201 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1138877007202 active site 1138877007203 (p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691 1138877007204 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1138877007205 Zn2+ binding site [ion binding]; other site 1138877007206 Mg2+ binding site [ion binding]; other site 1138877007207 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1138877007208 synthetase active site [active] 1138877007209 NTP binding site [chemical binding]; other site 1138877007210 metal binding site [ion binding]; metal-binding site 1138877007211 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1138877007212 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1138877007213 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1138877007214 active site 1138877007215 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1138877007216 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1138877007217 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1138877007218 Protein export membrane protein; Region: SecD_SecF; pfam02355 1138877007219 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 1138877007220 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1138877007221 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05886 1138877007222 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 1138877007223 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1138877007224 inhibitor-cofactor binding pocket; inhibition site 1138877007225 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138877007226 catalytic residue [active] 1138877007227 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1138877007228 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138877007229 acyl-activating enzyme (AAE) consensus motif; other site 1138877007230 AMP binding site [chemical binding]; other site 1138877007231 active site 1138877007232 CoA binding site [chemical binding]; other site 1138877007233 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 1138877007234 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 1138877007235 putative NAD(P) binding site [chemical binding]; other site 1138877007236 active site 1138877007237 putative substrate binding site [chemical binding]; other site 1138877007238 PE family; Region: PE; pfam00934 1138877007239 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1138877007240 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138877007241 Walker A motif; other site 1138877007242 ATP binding site [chemical binding]; other site 1138877007243 Walker B motif; other site 1138877007244 arginine finger; other site 1138877007245 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1138877007246 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1138877007247 RuvA N terminal domain; Region: RuvA_N; pfam01330 1138877007248 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1138877007249 active site 1138877007250 putative DNA-binding cleft [nucleotide binding]; other site 1138877007251 dimer interface [polypeptide binding]; other site 1138877007252 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1138877007253 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 1138877007254 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 1138877007255 putative active site [active] 1138877007256 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 1138877007257 Protein of unknown function DUF2617; Region: DUF2617; pfam10936 1138877007258 Domain of unknown function (DUF4247); Region: DUF4247; pfam14042 1138877007259 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1138877007260 Predicted spermidine synthase with an N-terminal membrane domain [General function prediction only]; Region: COG4262 1138877007261 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1138877007262 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1138877007263 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 1138877007264 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 1138877007265 hypothetical protein; Validated; Region: PRK00110 1138877007266 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 1138877007267 predicted active site [active] 1138877007268 catalytic triad [active] 1138877007269 acyl-CoA thioesterase II; Region: tesB; TIGR00189 1138877007270 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1138877007271 active site 1138877007272 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1138877007273 catalytic triad [active] 1138877007274 dimer interface [polypeptide binding]; other site 1138877007275 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 1138877007276 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 1138877007277 active site 1138877007278 multimer interface [polypeptide binding]; other site 1138877007279 Pyridoxamine-phosphate oxidase [Coenzyme metabolism]; Region: PdxH; COG0259 1138877007280 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1138877007281 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 1138877007282 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138877007283 PPE family; Region: PPE; pfam00823 1138877007284 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138877007285 PE-PPE domain; Region: PE-PPE; pfam08237 1138877007286 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_26; cd04685 1138877007287 nudix motif; other site 1138877007288 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1138877007289 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1138877007290 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1138877007291 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1138877007292 putative acyl-acceptor binding pocket; other site 1138877007293 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1138877007294 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 1138877007295 nucleotide binding site/active site [active] 1138877007296 HIT family signature motif; other site 1138877007297 catalytic residue [active] 1138877007298 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 1138877007299 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1138877007300 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1138877007301 active site 1138877007302 dimer interface [polypeptide binding]; other site 1138877007303 motif 1; other site 1138877007304 motif 2; other site 1138877007305 motif 3; other site 1138877007306 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1138877007307 anticodon binding site; other site 1138877007308 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1138877007309 phosphate binding site [ion binding]; other site 1138877007310 PE family; Region: PE; pfam00934 1138877007311 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4762 1138877007312 Predicted transcriptional regulator [Transcription]; Region: COG2345 1138877007313 Helix-turn-helix domain; Region: HTH_20; pfam12840 1138877007314 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1138877007315 Predicted transcriptional regulator [Transcription]; Region: COG2345 1138877007316 Helix-turn-helix domain; Region: HTH_20; pfam12840 1138877007317 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138877007318 S-adenosylmethionine binding site [chemical binding]; other site 1138877007319 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1138877007320 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1138877007321 Ligand Binding Site [chemical binding]; other site 1138877007322 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1138877007323 Ligand Binding Site [chemical binding]; other site 1138877007324 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1138877007325 Ligand Binding Site [chemical binding]; other site 1138877007326 Universal stress protein family; Region: Usp; pfam00582 1138877007327 Ligand Binding Site [chemical binding]; other site 1138877007328 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 1138877007329 active site 1138877007330 Peptidase family M50; Region: Peptidase_M50; pfam02163 1138877007331 putative substrate binding region [chemical binding]; other site 1138877007332 FOG: CBS domain [General function prediction only]; Region: COG0517 1138877007333 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612 1138877007334 FOG: CBS domain [General function prediction only]; Region: COG0517 1138877007335 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 1138877007336 peptide chain release factor 1; Provisional; Region: PRK04011 1138877007337 SHS2 domain protein implicated in nucleic acid metabolism [General function prediction only]; Region: COG1371 1138877007338 Uncharacterized conserved protein [Function unknown]; Region: RtcB; COG1690 1138877007339 hypothetical protein; Reviewed; Region: PRK09588 1138877007340 Domain of unknown function (DUF1876); Region: DUF1876; pfam08962 1138877007341 Hemerythrin-like domain; Region: Hr-like; cd12108 1138877007342 Fe binding site [ion binding]; other site 1138877007343 PE family; Region: PE; pfam00934 1138877007344 Chloramphenicol (Cm) phosphotransferase (CPT). Cm-inactivating enzyme; modifies the primary (C-3) hydroxyl of the antibiotic. Related structurally to shikimate kinase II; Region: CPT; cd00227 1138877007345 P-loop motif; other site 1138877007346 ATP binding site [chemical binding]; other site 1138877007347 Chloramphenicol (Cm) binding site [chemical binding]; other site 1138877007348 catalytic residue [active] 1138877007349 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1138877007350 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1138877007351 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1138877007352 anti sigma factor interaction site; other site 1138877007353 regulatory phosphorylation site [posttranslational modification]; other site 1138877007354 hypothetical protein; Provisional; Region: PRK02237 1138877007355 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1138877007356 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1138877007357 putative DNA binding site [nucleotide binding]; other site 1138877007358 putative Zn2+ binding site [ion binding]; other site 1138877007359 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 1138877007360 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1138877007361 putative metal binding site [ion binding]; other site 1138877007362 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1138877007363 dimerization interface [polypeptide binding]; other site 1138877007364 putative DNA binding site [nucleotide binding]; other site 1138877007365 putative Zn2+ binding site [ion binding]; other site 1138877007366 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 1138877007367 arsenical-resistance protein; Region: acr3; TIGR00832 1138877007368 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1138877007369 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1138877007370 active site 1138877007371 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1138877007372 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1138877007373 active site 1138877007374 DNA binding site [nucleotide binding] 1138877007375 Int/Topo IB signature motif; other site 1138877007376 Predicted phage phi-C31 gp36 major capsid-like protein [General function prediction only]; Region: COG4653 1138877007377 Phage capsid family; Region: Phage_capsid; pfam05065 1138877007378 Phage head maturation protease [General function prediction only]; Region: COG3740 1138877007379 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: COG3747 1138877007380 Protein of unknown function (DUF3631); Region: DUF3631; pfam12307 1138877007381 Protein of unknown function (DUF2742); Region: DUF2742; pfam10888 1138877007382 DNA binding domain, excisionase family; Region: excise; TIGR01764 1138877007383 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1138877007384 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1138877007385 active site 1138877007386 catalytic residues [active] 1138877007387 DNA binding site [nucleotide binding] 1138877007388 Int/Topo IB signature motif; other site 1138877007389 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1138877007390 MULE transposase domain; Region: MULE; pfam10551 1138877007391 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1138877007392 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1138877007393 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1138877007394 Coenzyme A binding pocket [chemical binding]; other site 1138877007395 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 1138877007396 hypothetical protein; Provisional; Region: PRK14059 1138877007397 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 1138877007398 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138877007399 TAP-like protein; Region: Abhydrolase_4; pfam08386 1138877007400 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 1138877007401 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 1138877007402 SelR domain; Region: SelR; pfam01641 1138877007403 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1138877007404 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138877007405 S-adenosylmethionine binding site [chemical binding]; other site 1138877007406 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 1138877007407 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 1138877007408 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1138877007409 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1138877007410 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1138877007411 substrate binding site [chemical binding]; other site 1138877007412 active site 1138877007413 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138877007414 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1138877007415 substrate binding site [chemical binding]; other site 1138877007416 oxyanion hole (OAH) forming residues; other site 1138877007417 trimer interface [polypeptide binding]; other site 1138877007418 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 1138877007419 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 1138877007420 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1138877007421 catalytic site [active] 1138877007422 putative active site [active] 1138877007423 putative substrate binding site [chemical binding]; other site 1138877007424 Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154 1138877007425 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1138877007426 TPP-binding site; other site 1138877007427 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1138877007428 PYR/PP interface [polypeptide binding]; other site 1138877007429 dimer interface [polypeptide binding]; other site 1138877007430 TPP binding site [chemical binding]; other site 1138877007431 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1138877007432 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1138877007433 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1138877007434 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 1138877007435 transmembrane helices; other site 1138877007436 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1138877007437 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 1138877007438 transmembrane helices; other site 1138877007439 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1138877007440 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1138877007441 Walker A/P-loop; other site 1138877007442 ATP binding site [chemical binding]; other site 1138877007443 Q-loop/lid; other site 1138877007444 ABC transporter signature motif; other site 1138877007445 Walker B; other site 1138877007446 D-loop; other site 1138877007447 H-loop/switch region; other site 1138877007448 TRAM domain; Region: TRAM; cl01282 1138877007449 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1138877007450 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1138877007451 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1138877007452 TrkA-N domain; Region: TrkA_N; pfam02254 1138877007453 TrkA-C domain; Region: TrkA_C; pfam02080 1138877007454 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1138877007455 TrkA-N domain; Region: TrkA_N; pfam02254 1138877007456 TrkA-C domain; Region: TrkA_C; pfam02080 1138877007457 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 1138877007458 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1138877007459 generic binding surface II; other site 1138877007460 ssDNA binding site; other site 1138877007461 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 1138877007462 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1138877007463 trimer interface [polypeptide binding]; other site 1138877007464 active site 1138877007465 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 1138877007466 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 1138877007467 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1138877007468 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1138877007469 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 1138877007470 active site 1138877007471 dimerization interface [polypeptide binding]; other site 1138877007472 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1138877007473 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1138877007474 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 1138877007475 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1138877007476 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1138877007477 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1138877007478 DNA binding residues [nucleotide binding] 1138877007479 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 1138877007480 homotrimer interaction site [polypeptide binding]; other site 1138877007481 putative active site [active] 1138877007482 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3502 1138877007483 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 1138877007484 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 1138877007485 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 1138877007486 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 1138877007487 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1138877007488 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1138877007489 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1138877007490 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1138877007491 DNA binding residues [nucleotide binding] 1138877007492 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 1138877007493 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1138877007494 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1138877007495 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 1138877007496 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 1138877007497 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 1138877007498 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1138877007499 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1138877007500 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1138877007501 PAC2 family; Region: PAC2; pfam09754 1138877007502 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138877007503 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1138877007504 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1138877007505 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 1138877007506 heme-binding site [chemical binding]; other site 1138877007507 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1138877007508 ATP cone domain; Region: ATP-cone; pfam03477 1138877007509 LysM domain; Region: LysM; pfam01476 1138877007510 LexA repressor; Validated; Region: PRK00215 1138877007511 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1138877007512 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1138877007513 Catalytic site [active] 1138877007514 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 1138877007515 LGFP repeat; Region: LGFP; pfam08310 1138877007516 LGFP repeat; Region: LGFP; pfam08310 1138877007517 LGFP repeat; Region: LGFP; pfam08310 1138877007518 LGFP repeat; Region: LGFP; pfam08310 1138877007519 LGFP repeat; Region: LGFP; pfam08310 1138877007520 Integral membrane protein TerC family; Region: TerC; cl10468 1138877007521 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138877007522 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138877007523 active site 1138877007524 GTPases [General function prediction only]; Region: HflX; COG2262 1138877007525 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1138877007526 HflX GTPase family; Region: HflX; cd01878 1138877007527 G1 box; other site 1138877007528 GTP/Mg2+ binding site [chemical binding]; other site 1138877007529 Switch I region; other site 1138877007530 G2 box; other site 1138877007531 G3 box; other site 1138877007532 Switch II region; other site 1138877007533 G4 box; other site 1138877007534 G5 box; other site 1138877007535 diaminopimelate epimerase; Region: DapF; TIGR00652 1138877007536 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1138877007537 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1138877007538 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1138877007539 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1138877007540 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 1138877007541 active site 1138877007542 metal binding site [ion binding]; metal-binding site 1138877007543 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1138877007544 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1138877007545 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1138877007546 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 1138877007547 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1138877007548 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1138877007549 FeS/SAM binding site; other site 1138877007550 TRAM domain; Region: TRAM; cl01282 1138877007551 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1138877007552 FeS/SAM binding site; other site 1138877007553 Uncharacterized protein conserved in bacteria [General function prediction only]; Region: OraA; COG2137 1138877007554 DNA recombination protein RecA; Reviewed; Region: recA; PRK09519 1138877007555 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1138877007556 hexamer interface [polypeptide binding]; other site 1138877007557 Walker A motif; other site 1138877007558 ATP binding site [chemical binding]; other site 1138877007559 Walker B motif; other site 1138877007560 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1138877007561 protein-splicing catalytic site; other site 1138877007562 thioester formation/cholesterol transfer; other site 1138877007563 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 1138877007564 recA bacterial DNA recombination protein; Region: RecA; cl17211 1138877007565 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 1138877007566 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 1138877007567 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1138877007568 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1138877007569 Limonene-1,2-epoxide hydrolase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LimA; COG4308 1138877007570 PE family; Region: PE; pfam00934 1138877007571 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 1138877007572 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1138877007573 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1138877007574 non-specific DNA binding site [nucleotide binding]; other site 1138877007575 salt bridge; other site 1138877007576 sequence-specific DNA binding site [nucleotide binding]; other site 1138877007577 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1138877007578 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1138877007579 Coenzyme A binding pocket [chemical binding]; other site 1138877007580 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1138877007581 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1138877007582 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 1138877007583 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1138877007584 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 1138877007585 classical (c) SDRs; Region: SDR_c; cd05233 1138877007586 NAD(P) binding site [chemical binding]; other site 1138877007587 active site 1138877007588 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138877007589 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1138877007590 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1138877007591 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1138877007592 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1138877007593 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1138877007594 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1138877007595 dimer interface [polypeptide binding]; other site 1138877007596 active site 1138877007597 catalytic residue [active] 1138877007598 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 1138877007599 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1138877007600 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1138877007601 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 1138877007602 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1138877007603 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 1138877007604 putative active site [active] 1138877007605 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 1138877007606 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 1138877007607 putative active site [active] 1138877007608 Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704 1138877007609 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1138877007610 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1138877007611 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 1138877007612 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1138877007613 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1138877007614 folate binding site [chemical binding]; other site 1138877007615 NADP+ binding site [chemical binding]; other site 1138877007616 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1138877007617 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1138877007618 dimerization interface [polypeptide binding]; other site 1138877007619 active site 1138877007620 Dienelactone hydrolase family; Region: DLH; pfam01738 1138877007621 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 1138877007622 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1138877007623 classical (c) SDRs; Region: SDR_c; cd05233 1138877007624 NAD(P) binding site [chemical binding]; other site 1138877007625 active site 1138877007626 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138877007627 PPE family; Region: PPE; pfam00823 1138877007628 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1138877007629 PE family; Region: PE; pfam00934 1138877007630 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1138877007631 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138877007632 PPE family; Region: PPE; pfam00823 1138877007633 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1138877007634 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1138877007635 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1138877007636 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1138877007637 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1138877007638 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1138877007639 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1138877007640 Coenzyme A binding pocket [chemical binding]; other site 1138877007641 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1138877007642 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 1138877007643 FMN-binding pocket [chemical binding]; other site 1138877007644 flavin binding motif; other site 1138877007645 phosphate binding motif [ion binding]; other site 1138877007646 beta-alpha-beta structure motif; other site 1138877007647 NAD binding pocket [chemical binding]; other site 1138877007648 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1138877007649 catalytic loop [active] 1138877007650 iron binding site [ion binding]; other site 1138877007651 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 1138877007652 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 1138877007653 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1138877007654 hydrophobic ligand binding site; other site 1138877007655 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1138877007656 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1138877007657 putative DNA binding site [nucleotide binding]; other site 1138877007658 putative Zn2+ binding site [ion binding]; other site 1138877007659 AsnC family; Region: AsnC_trans_reg; pfam01037 1138877007660 alanine dehydrogenase; Region: alaDH; TIGR00518 1138877007661 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1138877007662 hexamer interface [polypeptide binding]; other site 1138877007663 ligand binding site [chemical binding]; other site 1138877007664 putative active site [active] 1138877007665 NAD(P) binding site [chemical binding]; other site 1138877007666 Nitronate monooxygenase; Region: NMO; pfam03060 1138877007667 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1138877007668 FMN binding site [chemical binding]; other site 1138877007669 substrate binding site [chemical binding]; other site 1138877007670 putative catalytic residue [active] 1138877007671 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1138877007672 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1138877007673 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1138877007674 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 1138877007675 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 1138877007676 oligomer interface [polypeptide binding]; other site 1138877007677 RNA binding site [nucleotide binding]; other site 1138877007678 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1138877007679 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1138877007680 RNase E interface [polypeptide binding]; other site 1138877007681 trimer interface [polypeptide binding]; other site 1138877007682 active site 1138877007683 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1138877007684 putative nucleic acid binding region [nucleotide binding]; other site 1138877007685 G-X-X-G motif; other site 1138877007686 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1138877007687 RNA binding site [nucleotide binding]; other site 1138877007688 domain interface; other site 1138877007689 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1138877007690 16S/18S rRNA binding site [nucleotide binding]; other site 1138877007691 S13e-L30e interaction site [polypeptide binding]; other site 1138877007692 25S rRNA binding site [nucleotide binding]; other site 1138877007693 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1138877007694 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1138877007695 active site 1138877007696 Riboflavin kinase; Region: Flavokinase; pfam01687 1138877007697 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1138877007698 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 1138877007699 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 1138877007700 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1138877007701 putative DNA binding site [nucleotide binding]; other site 1138877007702 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1138877007703 FeoA domain; Region: FeoA; pfam04023 1138877007704 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138877007705 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138877007706 active site 1138877007707 lipid-transfer protein; Provisional; Region: PRK08256 1138877007708 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1138877007709 active site 1138877007710 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1138877007711 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1138877007712 Probable transposase; Region: OrfB_IS605; pfam01385 1138877007713 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 1138877007714 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 1138877007715 catalytic residues [active] 1138877007716 catalytic nucleophile [active] 1138877007717 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 1138877007718 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1138877007719 RNA binding site [nucleotide binding]; other site 1138877007720 active site 1138877007721 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 1138877007722 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 1138877007723 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1138877007724 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 1138877007725 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1138877007726 active site 1138877007727 metal binding site [ion binding]; metal-binding site 1138877007728 Uncharacterized conserved protein [Function unknown]; Region: COG4717 1138877007729 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 1138877007730 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 1138877007731 Predicted acyl esterases [General function prediction only]; Region: COG2936 1138877007732 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 1138877007733 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 1138877007734 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 1138877007735 Uncharacterized conserved protein [Function unknown]; Region: COG5586 1138877007736 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 1138877007737 Integrase core domain; Region: rve; pfam00665 1138877007738 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1138877007739 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1138877007740 Helix-turn-helix domain; Region: HTH_28; pfam13518 1138877007741 Winged helix-turn helix; Region: HTH_29; pfam13551 1138877007742 Integrase core domain; Region: rve; pfam00665 1138877007743 Integrase core domain; Region: rve_3; pfam13683 1138877007744 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 1138877007745 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 1138877007746 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638 1138877007747 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09636 1138877007748 CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cd09699 1138877007749 CRISPR/Cas system-associated RAMP superfamily protein Csm5; Region: Csm5_III-A; cd09662 1138877007750 CRISPR/Cas system-associated RAMP superfamily protein Csm4; Region: Csm4_III-A; cd09663 1138877007751 CRISPR/Cas system-associated RAMP superfamily protein Csm3; Region: Csm3_III-A; cd09684 1138877007752 CRISPR/Cas system-associated protein Csm2; Region: Csm2_III-A; cd09647 1138877007753 Predicted CRISPR-associated polymerase [Defense mechanisms]; Region: COG1353 1138877007754 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680 1138877007755 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 1138877007756 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4293 1138877007757 Uncharacterized conserved protein [Function unknown]; Region: COG2253 1138877007758 Protein of unknown function (DUF2005); Region: DUF2005; pfam09407 1138877007759 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4293 1138877007760 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 1138877007761 putative active site [active] 1138877007762 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1138877007763 enoyl-CoA hydratase; Provisional; Region: PRK06190 1138877007764 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138877007765 substrate binding site [chemical binding]; other site 1138877007766 oxyanion hole (OAH) forming residues; other site 1138877007767 trimer interface [polypeptide binding]; other site 1138877007768 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1138877007769 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1138877007770 Walker A/P-loop; other site 1138877007771 ATP binding site [chemical binding]; other site 1138877007772 Q-loop/lid; other site 1138877007773 ABC transporter signature motif; other site 1138877007774 Walker B; other site 1138877007775 D-loop; other site 1138877007776 H-loop/switch region; other site 1138877007777 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1138877007778 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1138877007779 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1138877007780 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1138877007781 dimer interface [polypeptide binding]; other site 1138877007782 conserved gate region; other site 1138877007783 putative PBP binding loops; other site 1138877007784 ABC-ATPase subunit interface; other site 1138877007785 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1138877007786 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1138877007787 dimer interface [polypeptide binding]; other site 1138877007788 conserved gate region; other site 1138877007789 putative PBP binding loops; other site 1138877007790 ABC-ATPase subunit interface; other site 1138877007791 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1138877007792 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 1138877007793 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1138877007794 DHH family; Region: DHH; pfam01368 1138877007795 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1138877007796 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1138877007797 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1138877007798 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 1138877007799 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1138877007800 G1 box; other site 1138877007801 putative GEF interaction site [polypeptide binding]; other site 1138877007802 GTP/Mg2+ binding site [chemical binding]; other site 1138877007803 Switch I region; other site 1138877007804 G2 box; other site 1138877007805 G3 box; other site 1138877007806 Switch II region; other site 1138877007807 G4 box; other site 1138877007808 G5 box; other site 1138877007809 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1138877007810 Translation-initiation factor 2; Region: IF-2; pfam11987 1138877007811 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1138877007812 Predicted nucleic-acid-binding protein implicated in transcription termination [Transcription]; Region: COG2740 1138877007813 putative RNA binding cleft [nucleotide binding]; other site 1138877007814 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1138877007815 NusA N-terminal domain; Region: NusA_N; pfam08529 1138877007816 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1138877007817 RNA binding site [nucleotide binding]; other site 1138877007818 homodimer interface [polypeptide binding]; other site 1138877007819 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1138877007820 G-X-X-G motif; other site 1138877007821 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1138877007822 G-X-X-G motif; other site 1138877007823 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1138877007824 Sm and related proteins; Region: Sm_like; cl00259 1138877007825 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1138877007826 putative oligomer interface [polypeptide binding]; other site 1138877007827 putative RNA binding site [nucleotide binding]; other site 1138877007828 Mitochondrial ATP synthase g subunit; Region: ATP-synt_G; pfam04718 1138877007829 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1138877007830 dinuclear metal binding motif [ion binding]; other site 1138877007831 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1138877007832 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1138877007833 dimer interface [polypeptide binding]; other site 1138877007834 motif 1; other site 1138877007835 active site 1138877007836 motif 2; other site 1138877007837 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 1138877007838 putative deacylase active site [active] 1138877007839 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1138877007840 active site 1138877007841 motif 3; other site 1138877007842 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1138877007843 anticodon binding site; other site 1138877007844 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138877007845 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1138877007846 putative substrate translocation pore; other site 1138877007847 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 1138877007848 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1138877007849 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1138877007850 homodimer interface [polypeptide binding]; other site 1138877007851 active site 1138877007852 SAM binding site [chemical binding]; other site 1138877007853 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 1138877007854 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1138877007855 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 1138877007856 catalytic triad [active] 1138877007857 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 1138877007858 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 1138877007859 homodimer interface [polypeptide binding]; other site 1138877007860 Walker A motif; other site 1138877007861 ATP binding site [chemical binding]; other site 1138877007862 hydroxycobalamin binding site [chemical binding]; other site 1138877007863 Walker B motif; other site 1138877007864 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 1138877007865 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138877007866 Walker A motif; other site 1138877007867 ATP binding site [chemical binding]; other site 1138877007868 Walker B motif; other site 1138877007869 arginine finger; other site 1138877007870 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 1138877007871 metal ion-dependent adhesion site (MIDAS); other site 1138877007872 Predicted acyltransferase [General function prediction only]; Region: ElaA; COG2153 1138877007873 malate:quinone oxidoreductase; Validated; Region: PRK05257 1138877007874 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1138877007875 PE family; Region: PE; pfam00934 1138877007876 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1138877007877 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1138877007878 mycothione reductase; Reviewed; Region: PRK07846 1138877007879 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1138877007880 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1138877007881 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1138877007882 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 1138877007883 short chain dehydrogenase; Provisional; Region: PRK06057 1138877007884 classical (c) SDRs; Region: SDR_c; cd05233 1138877007885 NAD(P) binding site [chemical binding]; other site 1138877007886 active site 1138877007887 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1138877007888 NAD(P)+ dependent aldehyde dehydrogenase family; Region: ALDH; cd07078 1138877007889 NAD(P) binding site [chemical binding]; other site 1138877007890 catalytic residues [active] 1138877007891 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 1138877007892 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1138877007893 catalytic triad [active] 1138877007894 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1138877007895 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1138877007896 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1138877007897 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1138877007898 active site 1138877007899 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1138877007900 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 1138877007901 putative active site [active] 1138877007902 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 1138877007903 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1138877007904 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1138877007905 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 1138877007906 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 1138877007907 Predicted acetyltransferase [General function prediction only]; Region: COG3393 1138877007908 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 1138877007909 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1138877007910 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1138877007911 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1138877007912 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 1138877007913 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1138877007914 active site 1138877007915 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1138877007916 protein binding site [polypeptide binding]; other site 1138877007917 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1138877007918 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1138877007919 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1138877007920 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1138877007921 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1138877007922 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 1138877007923 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 1138877007924 Fasciclin domain; Region: Fasciclin; pfam02469 1138877007925 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1138877007926 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1138877007927 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 1138877007928 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1138877007929 catalytic residues [active] 1138877007930 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 1138877007931 Fasciclin domain; Region: Fasciclin; pfam02469 1138877007932 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 1138877007933 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1138877007934 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 1138877007935 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1138877007936 catalytic residues [active] 1138877007937 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 1138877007938 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1138877007939 FeS/SAM binding site; other site 1138877007940 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1138877007941 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1138877007942 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1138877007943 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1138877007944 hinge region; other site 1138877007945 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1138877007946 putative nucleotide binding site [chemical binding]; other site 1138877007947 uridine monophosphate binding site [chemical binding]; other site 1138877007948 homohexameric interface [polypeptide binding]; other site 1138877007949 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1138877007950 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1138877007951 DNA binding site [nucleotide binding] 1138877007952 Probable transposase; Region: OrfB_IS605; pfam01385 1138877007953 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 1138877007954 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1138877007955 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1138877007956 Probable transposase; Region: OrfB_IS605; pfam01385 1138877007957 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 1138877007958 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 1138877007959 catalytic residues [active] 1138877007960 catalytic nucleophile [active] 1138877007961 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1138877007962 MarR family; Region: MarR; pfam01047 1138877007963 amidase; Provisional; Region: PRK07869 1138877007964 Amidase; Region: Amidase; pfam01425 1138877007965 elongation factor Ts; Provisional; Region: tsf; PRK09377 1138877007966 UBA/TS-N domain; Region: UBA; pfam00627 1138877007967 Elongation factor TS; Region: EF_TS; pfam00889 1138877007968 Elongation factor TS; Region: EF_TS; pfam00889 1138877007969 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1138877007970 rRNA interaction site [nucleotide binding]; other site 1138877007971 S8 interaction site; other site 1138877007972 putative laminin-1 binding site; other site 1138877007973 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1138877007974 Peptidase family M23; Region: Peptidase_M23; pfam01551 1138877007975 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138877007976 PPE family; Region: PPE; pfam00823 1138877007977 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1138877007978 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 1138877007979 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1138877007980 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1138877007981 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1138877007982 active site 1138877007983 DNA binding site [nucleotide binding] 1138877007984 Int/Topo IB signature motif; other site 1138877007985 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1138877007986 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1138877007987 FAD binding pocket [chemical binding]; other site 1138877007988 FAD binding motif [chemical binding]; other site 1138877007989 phosphate binding motif [ion binding]; other site 1138877007990 NAD binding pocket [chemical binding]; other site 1138877007991 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 1138877007992 DNA protecting protein DprA; Region: dprA; TIGR00732 1138877007993 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1138877007994 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1138877007995 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138877007996 Walker A motif; other site 1138877007997 ATP binding site [chemical binding]; other site 1138877007998 Walker B motif; other site 1138877007999 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1138877008000 hypothetical protein; Reviewed; Region: PRK12497 1138877008001 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 1138877008002 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 1138877008003 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 1138877008004 putative molybdopterin cofactor binding site [chemical binding]; other site 1138877008005 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 1138877008006 putative molybdopterin cofactor binding site; other site 1138877008007 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 1138877008008 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1138877008009 RNA/DNA hybrid binding site [nucleotide binding]; other site 1138877008010 active site 1138877008011 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1138877008012 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1138877008013 Catalytic site [active] 1138877008014 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1138877008015 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1138877008016 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1138877008017 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1138877008018 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1138877008019 RimM N-terminal domain; Region: RimM; pfam01782 1138877008020 hypothetical protein; Provisional; Region: PRK02821 1138877008021 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 1138877008022 G-X-X-G motif; other site 1138877008023 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 1138877008024 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 1138877008025 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1138877008026 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1138877008027 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138877008028 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138877008029 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 1138877008030 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 1138877008031 active site 1138877008032 putative substrate binding pocket [chemical binding]; other site 1138877008033 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1138877008034 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1138877008035 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1138877008036 active site 1138877008037 ATP binding site [chemical binding]; other site 1138877008038 substrate binding site [chemical binding]; other site 1138877008039 activation loop (A-loop); other site 1138877008040 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 1138877008041 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 1138877008042 active site 1138877008043 signal recognition particle protein; Provisional; Region: PRK10867 1138877008044 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1138877008045 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1138877008046 P loop; other site 1138877008047 GTP binding site [chemical binding]; other site 1138877008048 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1138877008049 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1138877008050 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1138877008051 ATP binding site [chemical binding]; other site 1138877008052 putative Mg++ binding site [ion binding]; other site 1138877008053 PII uridylyl-transferase; Provisional; Region: PRK03381 1138877008054 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1138877008055 metal binding triad; other site 1138877008056 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1138877008057 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1138877008058 Zn2+ binding site [ion binding]; other site 1138877008059 Mg2+ binding site [ion binding]; other site 1138877008060 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1138877008061 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1138877008062 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1138877008063 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 1138877008064 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1138877008065 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1138877008066 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1138877008067 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1138877008068 Walker A/P-loop; other site 1138877008069 ATP binding site [chemical binding]; other site 1138877008070 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 1138877008071 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1138877008072 ABC transporter signature motif; other site 1138877008073 Walker B; other site 1138877008074 D-loop; other site 1138877008075 H-loop/switch region; other site 1138877008076 acylphosphatase; Provisional; Region: PRK14422 1138877008077 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 1138877008078 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1138877008079 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1138877008080 DNA binding site [nucleotide binding] 1138877008081 catalytic residue [active] 1138877008082 H2TH interface [polypeptide binding]; other site 1138877008083 putative catalytic residues [active] 1138877008084 turnover-facilitating residue; other site 1138877008085 intercalation triad [nucleotide binding]; other site 1138877008086 8OG recognition residue [nucleotide binding]; other site 1138877008087 putative reading head residues; other site 1138877008088 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1138877008089 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1138877008090 ribonuclease III; Reviewed; Region: rnc; PRK00102 1138877008091 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1138877008092 dimerization interface [polypeptide binding]; other site 1138877008093 active site 1138877008094 metal binding site [ion binding]; metal-binding site 1138877008095 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1138877008096 dsRNA binding site [nucleotide binding]; other site 1138877008097 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 1138877008098 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 1138877008099 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 1138877008100 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1138877008101 acyl-CoA synthetase; Validated; Region: PRK05850 1138877008102 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1138877008103 acyl-activating enzyme (AAE) consensus motif; other site 1138877008104 active site 1138877008105 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138877008106 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1138877008107 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1138877008108 active site 1138877008109 Acyl transferase domain; Region: Acyl_transf_1; pfam00698 1138877008110 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1138877008111 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 1138877008112 NADP binding site [chemical binding]; other site 1138877008113 KR domain; Region: KR; pfam08659 1138877008114 active site 1138877008115 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1138877008116 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1138877008117 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1138877008118 active site 1138877008119 Acyl transferase domain; Region: Acyl_transf_1; cl08282 1138877008120 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 1138877008121 KR domain; Region: KR; pfam08659 1138877008122 NADP binding site [chemical binding]; other site 1138877008123 active site 1138877008124 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1138877008125 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1138877008126 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1138877008127 active site 1138877008128 Acyl transferase domain; Region: Acyl_transf_1; cl08282 1138877008129 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1138877008130 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138877008131 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1138877008132 Enoylreductase; Region: PKS_ER; smart00829 1138877008133 NAD(P) binding site [chemical binding]; other site 1138877008134 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1138877008135 KR domain; Region: KR; pfam08659 1138877008136 putative NADP binding site [chemical binding]; other site 1138877008137 active site 1138877008138 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1138877008139 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1138877008140 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1138877008141 active site 1138877008142 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1138877008143 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1138877008144 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1138877008145 KR domain; Region: KR; pfam08659 1138877008146 putative NADP binding site [chemical binding]; other site 1138877008147 active site 1138877008148 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1138877008149 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1138877008150 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1138877008151 active site 1138877008152 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1138877008153 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138877008154 Condensation domain; Region: Condensation; pfam00668 1138877008155 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1138877008156 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1138877008157 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1138877008158 Walker A/P-loop; other site 1138877008159 ATP binding site [chemical binding]; other site 1138877008160 Q-loop/lid; other site 1138877008161 ABC transporter signature motif; other site 1138877008162 Walker B; other site 1138877008163 D-loop; other site 1138877008164 H-loop/switch region; other site 1138877008165 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1138877008166 ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025 1138877008167 ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025 1138877008168 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1138877008169 acyltransferase PapA5; Provisional; Region: PRK09294 1138877008170 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1138877008171 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1138877008172 active site 1138877008173 Acyl transferase domain; Region: Acyl_transf_1; pfam00698 1138877008174 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1138877008175 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138877008176 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1138877008177 Enoylreductase; Region: PKS_ER; smart00829 1138877008178 NAD(P) binding site [chemical binding]; other site 1138877008179 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1138877008180 KR domain; Region: KR; pfam08659 1138877008181 putative NADP binding site [chemical binding]; other site 1138877008182 active site 1138877008183 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1138877008184 acyl-CoA synthetase; Validated; Region: PRK05850 1138877008185 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1138877008186 acyl-activating enzyme (AAE) consensus motif; other site 1138877008187 active site 1138877008188 MMPL family; Region: MMPL; pfam03176 1138877008189 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1138877008190 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1138877008191 Integrase core domain; Region: rve; pfam00665 1138877008192 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1138877008193 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 1138877008194 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138877008195 ATP binding site [chemical binding]; other site 1138877008196 Walker A motif; other site 1138877008197 Walker B motif; other site 1138877008198 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 1138877008199 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1138877008200 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1138877008201 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1138877008202 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138877008203 Enoylreductase; Region: PKS_ER; smart00829 1138877008204 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1138877008205 NAD(P) binding site [chemical binding]; other site 1138877008206 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 1138877008207 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1138877008208 putative NADP binding site [chemical binding]; other site 1138877008209 active site 1138877008210 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1138877008211 Erythronolide synthase docking; Region: Docking; pfam08990 1138877008212 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1138877008213 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1138877008214 active site 1138877008215 acyl-CoA synthetase; Validated; Region: PRK06060 1138877008216 Benzoate CoA ligase (BCL) and similar adenylate forming enzymes; Region: BCL_like; cd05919 1138877008217 dimer interface [polypeptide binding]; other site 1138877008218 acyl-activating enzyme (AAE) consensus motif; other site 1138877008219 putative active site [active] 1138877008220 putative AMP binding site [chemical binding]; other site 1138877008221 putative CoA binding site [chemical binding]; other site 1138877008222 chemical substrate binding site [chemical binding]; other site 1138877008223 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1138877008224 4-hydroxybenzoate synthetase (chorismate lyase) [Coenzyme metabolism]; Region: UbiC; COG3161 1138877008225 acyl-CoA synthetase; Validated; Region: PRK05850 1138877008226 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1138877008227 acyl-activating enzyme (AAE) consensus motif; other site 1138877008228 active site 1138877008229 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1138877008230 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1138877008231 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138877008232 S-adenosylmethionine binding site [chemical binding]; other site 1138877008233 Uncharacterized conserved protein [Function unknown]; Region: COG3268 1138877008234 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1138877008235 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138877008236 S-adenosylmethionine binding site [chemical binding]; other site 1138877008237 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 1138877008238 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 1138877008239 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 1138877008240 metal-binding site 1138877008241 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1138877008242 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1138877008243 active site 1138877008244 TDP-binding site; other site 1138877008245 acceptor substrate-binding pocket; other site 1138877008246 Cephalosporin hydroxylase [Defense mechanisms]; Region: CmcI; COG3510 1138877008247 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 1138877008248 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1138877008249 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1138877008250 active site 1138877008251 TDP-binding site; other site 1138877008252 acceptor substrate-binding pocket; other site 1138877008253 Predicted permease; Region: DUF318; pfam03773 1138877008254 formyltetrahydrofolate deformylase; Region: PurU; TIGR00655 1138877008255 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1138877008256 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1138877008257 putative active site [active] 1138877008258 putative substrate binding site [chemical binding]; other site 1138877008259 putative cosubstrate binding site; other site 1138877008260 catalytic site [active] 1138877008261 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1138877008262 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1138877008263 active site 1138877008264 (T/H)XGH motif; other site 1138877008265 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 1138877008266 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138877008267 S-adenosylmethionine binding site [chemical binding]; other site 1138877008268 pyruvate carboxylase; Reviewed; Region: PRK12999 1138877008269 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1138877008270 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1138877008271 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1138877008272 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1138877008273 active site 1138877008274 catalytic residues [active] 1138877008275 metal binding site [ion binding]; metal-binding site 1138877008276 homodimer binding site [polypeptide binding]; other site 1138877008277 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1138877008278 carboxyltransferase (CT) interaction site; other site 1138877008279 biotinylation site [posttranslational modification]; other site 1138877008280 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 1138877008281 putative active site [active] 1138877008282 redox center [active] 1138877008283 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1138877008284 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 1138877008285 catalytic residues [active] 1138877008286 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1138877008287 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1138877008288 substrate binding pocket [chemical binding]; other site 1138877008289 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 1138877008290 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1138877008291 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1138877008292 active site 1138877008293 catalytic tetrad [active] 1138877008294 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1138877008295 RecG-like helicase [DNA replication, recombination, and repair / Transcription]; Region: RecG; COG1200 1138877008296 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1138877008297 generic binding surface II; other site 1138877008298 ssDNA binding site; other site 1138877008299 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1138877008300 ATP binding site [chemical binding]; other site 1138877008301 putative Mg++ binding site [ion binding]; other site 1138877008302 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1138877008303 nucleotide binding region [chemical binding]; other site 1138877008304 ATP-binding site [chemical binding]; other site 1138877008305 DAK2 domain; Region: Dak2; cl03685 1138877008306 Dihydroxyacetone kinase family; Region: Dak1_2; pfam13684 1138877008307 DAK2 domain; Region: Dak2; cl03685 1138877008308 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1138877008309 ligand binding site [chemical binding]; other site 1138877008310 active site 1138877008311 UGI interface [polypeptide binding]; other site 1138877008312 catalytic site [active] 1138877008313 thiamine monophosphate kinase; Provisional; Region: PRK05731 1138877008314 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1138877008315 ATP binding site [chemical binding]; other site 1138877008316 dimerization interface [polypeptide binding]; other site 1138877008317 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1138877008318 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1138877008319 Probable transposase; Region: OrfB_IS605; pfam01385 1138877008320 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 1138877008321 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 1138877008322 catalytic residues [active] 1138877008323 catalytic nucleophile [active] 1138877008324 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 1138877008325 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1138877008326 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1138877008327 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1138877008328 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1138877008329 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1138877008330 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1138877008331 Predicted nucleotidyltransferase, CobY/MobA/RfbA family [General function prediction only]; Region: COG1920 1138877008332 polyphosphate kinase; Provisional; Region: PRK05443 1138877008333 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1138877008334 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1138877008335 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 1138877008336 putative domain interface [polypeptide binding]; other site 1138877008337 putative active site [active] 1138877008338 catalytic site [active] 1138877008339 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 1138877008340 putative domain interface [polypeptide binding]; other site 1138877008341 putative active site [active] 1138877008342 catalytic site [active] 1138877008343 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1138877008344 active site 1138877008345 Ap6A binding site [chemical binding]; other site 1138877008346 nudix motif; other site 1138877008347 metal binding site [ion binding]; metal-binding site 1138877008348 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1138877008349 catalytic core [active] 1138877008350 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1138877008351 IHF - DNA interface [nucleotide binding]; other site 1138877008352 IHF dimer interface [polypeptide binding]; other site 1138877008353 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1138877008354 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1138877008355 substrate binding site [chemical binding]; other site 1138877008356 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1138877008357 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1138877008358 substrate binding site [chemical binding]; other site 1138877008359 ligand binding site [chemical binding]; other site 1138877008360 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1138877008361 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1138877008362 Bacterial transcriptional regulator; Region: IclR; pfam01614 1138877008363 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138877008364 S-adenosylmethionine binding site [chemical binding]; other site 1138877008365 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 1138877008366 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1138877008367 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1138877008368 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1138877008369 active site 1138877008370 HIGH motif; other site 1138877008371 nucleotide binding site [chemical binding]; other site 1138877008372 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1138877008373 active site 1138877008374 KMSKS motif; other site 1138877008375 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1138877008376 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 1138877008377 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1138877008378 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138877008379 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1138877008380 putative substrate translocation pore; other site 1138877008381 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 1138877008382 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 1138877008383 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1138877008384 ligand binding site [chemical binding]; other site 1138877008385 NAD binding site [chemical binding]; other site 1138877008386 dimerization interface [polypeptide binding]; other site 1138877008387 catalytic site [active] 1138877008388 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 1138877008389 putative L-serine binding site [chemical binding]; other site 1138877008390 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1138877008391 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1138877008392 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1138877008393 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1138877008394 phosphorylation site [posttranslational modification] 1138877008395 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 1138877008396 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 1138877008397 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 1138877008398 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1138877008399 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1138877008400 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1138877008401 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1138877008402 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1138877008403 putative valine binding site [chemical binding]; other site 1138877008404 dimer interface [polypeptide binding]; other site 1138877008405 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1138877008406 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 1138877008407 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1138877008408 PYR/PP interface [polypeptide binding]; other site 1138877008409 dimer interface [polypeptide binding]; other site 1138877008410 TPP binding site [chemical binding]; other site 1138877008411 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1138877008412 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1138877008413 TPP-binding site [chemical binding]; other site 1138877008414 dimer interface [polypeptide binding]; other site 1138877008415 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1138877008416 Predicted membrane protein [Function unknown]; Region: COG2259 1138877008417 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 1138877008418 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1138877008419 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1138877008420 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1138877008421 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1138877008422 GatB domain; Region: GatB_Yqey; smart00845 1138877008423 6-phosphofructokinase; Provisional; Region: PRK03202 1138877008424 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1138877008425 active site 1138877008426 ADP/pyrophosphate binding site [chemical binding]; other site 1138877008427 dimerization interface [polypeptide binding]; other site 1138877008428 allosteric effector site; other site 1138877008429 fructose-1,6-bisphosphate binding site; other site 1138877008430 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1138877008431 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1138877008432 aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, C subunit; Region: gatC; TIGR00135 1138877008433 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 1138877008434 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1138877008435 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1138877008436 nucleotide binding pocket [chemical binding]; other site 1138877008437 K-X-D-G motif; other site 1138877008438 catalytic site [active] 1138877008439 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1138877008440 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1138877008441 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1138877008442 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1138877008443 Dimer interface [polypeptide binding]; other site 1138877008444 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310 1138877008445 PknH-like extracellular domain; Region: PknH_C; pfam14032 1138877008446 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1138877008447 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138877008448 PPE family; Region: PPE; pfam00823 1138877008449 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1138877008450 MULE transposase domain; Region: MULE; pfam10551 1138877008451 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 1138877008452 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1138877008453 Ligand Binding Site [chemical binding]; other site 1138877008454 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1138877008455 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1138877008456 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1138877008457 catalytic residue [active] 1138877008458 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1138877008459 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1138877008460 putative acyl-acceptor binding pocket; other site 1138877008461 Putative hemolysin [General function prediction only]; Region: COG3176 1138877008462 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1138877008463 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1138877008464 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1138877008465 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1138877008466 Ligand binding site [chemical binding]; other site 1138877008467 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1138877008468 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138877008469 S-adenosylmethionine binding site [chemical binding]; other site 1138877008470 Uncharacterized conserved protein [Function unknown]; Region: COG1543 1138877008471 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 1138877008472 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 1138877008473 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1138877008474 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1138877008475 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 1138877008476 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 1138877008477 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1138877008478 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1138877008479 trimer interface [polypeptide binding]; other site 1138877008480 active site 1138877008481 substrate binding site [chemical binding]; other site 1138877008482 CoA binding site [chemical binding]; other site 1138877008483 FOG: WD40-like repeat [Function unknown]; Region: COG1520 1138877008484 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1138877008485 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138877008486 S-adenosylmethionine binding site [chemical binding]; other site 1138877008487 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138877008488 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1138877008489 substrate binding site [chemical binding]; other site 1138877008490 oxyanion hole (OAH) forming residues; other site 1138877008491 trimer interface [polypeptide binding]; other site 1138877008492 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119 1138877008493 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1138877008494 Walker A/P-loop; other site 1138877008495 ATP binding site [chemical binding]; other site 1138877008496 Q-loop/lid; other site 1138877008497 ABC transporter signature motif; other site 1138877008498 Walker B; other site 1138877008499 D-loop; other site 1138877008500 H-loop/switch region; other site 1138877008501 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 1138877008502 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 1138877008503 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1138877008504 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1138877008505 motif II; other site 1138877008506 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1138877008507 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1138877008508 D-pathway; other site 1138877008509 Putative ubiquinol binding site [chemical binding]; other site 1138877008510 Low-spin heme (heme b) binding site [chemical binding]; other site 1138877008511 Putative water exit pathway; other site 1138877008512 Binuclear center (heme o3/CuB) [ion binding]; other site 1138877008513 K-pathway; other site 1138877008514 Putative proton exit pathway; other site 1138877008515 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1138877008516 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1138877008517 siderophore binding site; other site 1138877008518 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1138877008519 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1138877008520 putative NAD(P) binding site [chemical binding]; other site 1138877008521 putative substrate binding site [chemical binding]; other site 1138877008522 catalytic Zn binding site [ion binding]; other site 1138877008523 structural Zn binding site [ion binding]; other site 1138877008524 dimer interface [polypeptide binding]; other site 1138877008525 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 1138877008526 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1138877008527 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1138877008528 dimer interface [polypeptide binding]; other site 1138877008529 putative radical transfer pathway; other site 1138877008530 diiron center [ion binding]; other site 1138877008531 tyrosyl radical; other site 1138877008532 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1138877008533 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1138877008534 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138877008535 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138877008536 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 1138877008537 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1138877008538 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1138877008539 active site 1138877008540 dimer interface [polypeptide binding]; other site 1138877008541 catalytic residues [active] 1138877008542 effector binding site; other site 1138877008543 R2 peptide binding site; other site 1138877008544 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 1138877008545 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1138877008546 catalytic residues [active] 1138877008547 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1138877008548 Predicted flavoprotein [General function prediction only]; Region: COG0431 1138877008549 DNA polymerase IV; Validated; Region: PRK03352 1138877008550 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1138877008551 active site 1138877008552 DNA binding site [nucleotide binding] 1138877008553 short chain dehydrogenase; Provisional; Region: PRK07832 1138877008554 classical (c) SDRs; Region: SDR_c; cd05233 1138877008555 NAD(P) binding site [chemical binding]; other site 1138877008556 active site 1138877008557 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138877008558 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138877008559 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138877008560 Cytochrome P450; Region: p450; cl12078 1138877008561 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1138877008562 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1138877008563 DNA-binding site [nucleotide binding]; DNA binding site 1138877008564 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1138877008565 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1138877008566 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1138877008567 DNA-binding site [nucleotide binding]; DNA binding site 1138877008568 FCD domain; Region: FCD; pfam07729 1138877008569 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138877008570 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1138877008571 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138877008572 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138877008573 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138877008574 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138877008575 active site 1138877008576 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180 1138877008577 Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901 1138877008578 active site 1138877008579 DNA binding site [nucleotide binding] 1138877008580 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 1138877008581 DNA binding site [nucleotide binding] 1138877008582 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 1138877008583 Carbon starvation protein CstA; Region: CstA; pfam02554 1138877008584 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1138877008585 Predicted membrane protein [Function unknown]; Region: COG2259 1138877008586 Small Multidrug Resistance protein; Region: Multi_Drug_Res; pfam00893 1138877008587 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 1138877008588 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138877008589 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1138877008590 phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132 1138877008591 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 1138877008592 active site 1138877008593 substrate binding site [chemical binding]; other site 1138877008594 metal binding site [ion binding]; metal-binding site 1138877008595 camphor resistance protein CrcB; Provisional; Region: PRK14216 1138877008596 camphor resistance protein CrcB; Provisional; Region: PRK14228 1138877008597 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 1138877008598 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 1138877008599 Uncharacterized ACR, COG1993; Region: DUF190; pfam02641 1138877008600 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1138877008601 Uncharacterized conserved protein [Function unknown]; Region: COG3189 1138877008602 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1138877008603 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1138877008604 active site 1138877008605 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1138877008606 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 1138877008607 putative hydrophobic ligand binding site [chemical binding]; other site 1138877008608 protein interface [polypeptide binding]; other site 1138877008609 gate; other site 1138877008610 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1138877008611 Sulfatase; Region: Sulfatase; pfam00884 1138877008612 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1138877008613 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1138877008614 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1138877008615 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1138877008616 active site 1138877008617 ATP binding site [chemical binding]; other site 1138877008618 substrate binding site [chemical binding]; other site 1138877008619 activation loop (A-loop); other site 1138877008620 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 1138877008621 AAA ATPase domain; Region: AAA_16; pfam13191 1138877008622 Nucleotidyl transferase of unknown function (DUF2204); Region: DUF2204; pfam09970 1138877008623 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1138877008624 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1138877008625 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1138877008626 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1138877008627 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1138877008628 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1138877008629 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1138877008630 short chain dehydrogenase; Provisional; Region: PRK07832 1138877008631 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138877008632 NAD(P) binding site [chemical binding]; other site 1138877008633 active site 1138877008634 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 1138877008635 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1138877008636 NAD binding site [chemical binding]; other site 1138877008637 catalytic Zn binding site [ion binding]; other site 1138877008638 substrate binding site [chemical binding]; other site 1138877008639 structural Zn binding site [ion binding]; other site 1138877008640 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1138877008641 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1138877008642 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1138877008643 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1138877008644 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 1138877008645 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1138877008646 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138877008647 acyl-activating enzyme (AAE) consensus motif; other site 1138877008648 AMP binding site [chemical binding]; other site 1138877008649 active site 1138877008650 CoA binding site [chemical binding]; other site 1138877008651 SPFH domain / Band 7 family; Region: Band_7; pfam01145 1138877008652 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1138877008653 Patatin-like phospholipase; Region: Patatin; pfam01734 1138877008654 probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841 1138877008655 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1138877008656 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354 1138877008657 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138877008658 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138877008659 active site 1138877008660 Predicted transcriptional regulators [Transcription]; Region: COG1733 1138877008661 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1138877008662 dimerization interface [polypeptide binding]; other site 1138877008663 putative DNA binding site [nucleotide binding]; other site 1138877008664 putative Zn2+ binding site [ion binding]; other site 1138877008665 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 1138877008666 PE family; Region: PE; pfam00934 1138877008667 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1138877008668 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1138877008669 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1138877008670 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1138877008671 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1138877008672 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1138877008673 SmpB-tmRNA interface; other site 1138877008674 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1138877008675 FtsX-like permease family; Region: FtsX; pfam02687 1138877008676 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1138877008677 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1138877008678 Walker A/P-loop; other site 1138877008679 ATP binding site [chemical binding]; other site 1138877008680 Q-loop/lid; other site 1138877008681 ABC transporter signature motif; other site 1138877008682 Walker B; other site 1138877008683 D-loop; other site 1138877008684 H-loop/switch region; other site 1138877008685 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1138877008686 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1138877008687 peptide chain release factor 2; Validated; Region: prfB; PRK00578 1138877008688 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1138877008689 RF-1 domain; Region: RF-1; pfam00472 1138877008690 ferredoxin-NADP+ reductase; Region: PLN02852 1138877008691 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1138877008692 FAD binding domain; Region: FAD_binding_4; pfam01565 1138877008693 Molybdenum cofactor biosynthesis enzyme [Coenzyme metabolism]; Region: MoaA; COG2896 1138877008694 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1138877008695 FeS/SAM binding site; other site 1138877008696 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1138877008697 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 1138877008698 aromatic arch; other site 1138877008699 DCoH dimer interaction site [polypeptide binding]; other site 1138877008700 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 1138877008701 DCoH tetramer interaction site [polypeptide binding]; other site 1138877008702 substrate binding site [chemical binding]; other site 1138877008703 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1138877008704 trimer interface [polypeptide binding]; other site 1138877008705 dimer interface [polypeptide binding]; other site 1138877008706 putative active site [active] 1138877008707 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1138877008708 MoaE interaction surface [polypeptide binding]; other site 1138877008709 MoeB interaction surface [polypeptide binding]; other site 1138877008710 thiocarboxylated glycine; other site 1138877008711 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1138877008712 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 1138877008713 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1138877008714 nucleoside/Zn binding site; other site 1138877008715 dimer interface [polypeptide binding]; other site 1138877008716 catalytic motif [active] 1138877008717 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1138877008718 MULE transposase domain; Region: MULE; pfam10551 1138877008719 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 1138877008720 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1138877008721 ATP binding site [chemical binding]; other site 1138877008722 substrate interface [chemical binding]; other site 1138877008723 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1138877008724 active site residue [active] 1138877008725 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1138877008726 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1138877008727 active site residue [active] 1138877008728 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1138877008729 active site residue [active] 1138877008730 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 1138877008731 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1138877008732 MoaE homodimer interface [polypeptide binding]; other site 1138877008733 MoaD interaction [polypeptide binding]; other site 1138877008734 active site residues [active] 1138877008735 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138877008736 S-adenosylmethionine binding site [chemical binding]; other site 1138877008737 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138877008738 Cytochrome P450; Region: p450; cl12078 1138877008739 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 1138877008740 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 1138877008741 DNA binding site [nucleotide binding] 1138877008742 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138877008743 PPE family; Region: PPE; pfam00823 1138877008744 putative transposase OrfB; Reviewed; Region: PHA02517 1138877008745 HTH-like domain; Region: HTH_21; pfam13276 1138877008746 Integrase core domain; Region: rve; pfam00665 1138877008747 Integrase core domain; Region: rve_3; pfam13683 1138877008748 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1138877008749 Transposase; Region: HTH_Tnp_1; cl17663 1138877008750 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138877008751 PPE family; Region: PPE; pfam00823 1138877008752 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1138877008753 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 1138877008754 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1138877008755 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1138877008756 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1138877008757 dimer interface [polypeptide binding]; other site 1138877008758 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1138877008759 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1138877008760 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1138877008761 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1138877008762 Histidine kinase; Region: HisKA_3; pfam07730 1138877008763 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1138877008764 ATP binding site [chemical binding]; other site 1138877008765 Mg2+ binding site [ion binding]; other site 1138877008766 G-X-G motif; other site 1138877008767 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1138877008768 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1138877008769 active site 1138877008770 phosphorylation site [posttranslational modification] 1138877008771 intermolecular recognition site; other site 1138877008772 dimerization interface [polypeptide binding]; other site 1138877008773 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1138877008774 DNA binding residues [nucleotide binding] 1138877008775 dimerization interface [polypeptide binding]; other site 1138877008776 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1138877008777 Ligand Binding Site [chemical binding]; other site 1138877008778 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138877008779 PPE family; Region: PPE; pfam00823 1138877008780 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1138877008781 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1138877008782 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 1138877008783 active site 1138877008784 AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337 1138877008785 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1138877008786 FeS/SAM binding site; other site 1138877008787 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138877008788 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138877008789 active site 1138877008790 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138877008791 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138877008792 active site 1138877008793 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1138877008794 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 1138877008795 NAD(P) binding site [chemical binding]; other site 1138877008796 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1138877008797 active site 1138877008798 phosphorylation site [posttranslational modification] 1138877008799 intermolecular recognition site; other site 1138877008800 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138877008801 PPE family; Region: PPE; pfam00823 1138877008802 NADH dehydrogenase subunit A; Validated; Region: PRK07928 1138877008803 NADH dehydrogenase subunit B; Validated; Region: PRK06411 1138877008804 NADH dehydrogenase subunit C; Provisional; Region: PRK07785 1138877008805 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 1138877008806 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 1138877008807 NADH dehydrogenase subunit D; Validated; Region: PRK06075 1138877008808 NADH dehydrogenase subunit E; Validated; Region: PRK07539 1138877008809 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1138877008810 putative dimer interface [polypeptide binding]; other site 1138877008811 [2Fe-2S] cluster binding site [ion binding]; other site 1138877008812 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 1138877008813 SLBB domain; Region: SLBB; pfam10531 1138877008814 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 1138877008815 NADH dehydrogenase subunit G; Validated; Region: PRK07860 1138877008816 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1138877008817 catalytic loop [active] 1138877008818 iron binding site [ion binding]; other site 1138877008819 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1138877008820 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 1138877008821 [4Fe-4S] binding site [ion binding]; other site 1138877008822 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 1138877008823 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1138877008824 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1138877008825 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 1138877008826 4Fe-4S binding domain; Region: Fer4; pfam00037 1138877008827 4Fe-4S binding domain; Region: Fer4; pfam00037 1138877008828 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 1138877008829 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 1138877008830 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 1138877008831 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1138877008832 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1138877008833 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 1138877008834 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1138877008835 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1138877008836 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1138877008837 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138877008838 PPE family; Region: PPE; pfam00823 1138877008839 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138877008840 PPE family; Region: PPE; pfam00823 1138877008841 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 1138877008842 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138877008843 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1138877008844 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1138877008845 [2Fe-2S] cluster binding site [ion binding]; other site 1138877008846 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_1; cd08885 1138877008847 putative alpha subunit interface [polypeptide binding]; other site 1138877008848 putative active site [active] 1138877008849 putative substrate binding site [chemical binding]; other site 1138877008850 Fe binding site [ion binding]; other site 1138877008851 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1138877008852 Protein of unknown function DUF58; Region: DUF58; pfam01882 1138877008853 MoxR-like ATPases [General function prediction only]; Region: COG0714 1138877008854 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138877008855 Walker A motif; other site 1138877008856 ATP binding site [chemical binding]; other site 1138877008857 Walker B motif; other site 1138877008858 arginine finger; other site 1138877008859 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 1138877008860 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138877008861 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138877008862 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1138877008863 putative active site [active] 1138877008864 putative substrate binding site [chemical binding]; other site 1138877008865 ATP binding site [chemical binding]; other site 1138877008866 Phosphotransferase enzyme family; Region: APH; pfam01636 1138877008867 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 1138877008868 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1138877008869 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1138877008870 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138877008871 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1138877008872 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138877008873 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138877008874 short chain dehydrogenase; Validated; Region: PRK08264 1138877008875 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138877008876 NAD(P) binding site [chemical binding]; other site 1138877008877 active site 1138877008878 amidase; Provisional; Region: PRK06170 1138877008879 Amidase; Region: Amidase; pfam01425 1138877008880 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138877008881 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138877008882 TAP-like protein; Region: Abhydrolase_4; pfam08386 1138877008883 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1138877008884 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 1138877008885 AAA domain; Region: AAA_14; pfam13173 1138877008886 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1138877008887 putative active site [active] 1138877008888 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1138877008889 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4683 1138877008890 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1138877008891 non-specific DNA binding site [nucleotide binding]; other site 1138877008892 salt bridge; other site 1138877008893 sequence-specific DNA binding site [nucleotide binding]; other site 1138877008894 RES domain; Region: RES; pfam08808 1138877008895 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1138877008896 Helix-turn-helix domain; Region: HTH_38; pfam13936 1138877008897 Integrase core domain; Region: rve; pfam00665 1138877008898 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1138877008899 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1138877008900 hypothetical protein; Validated; Region: PRK00068 1138877008901 Uncharacterized conserved protein [Function unknown]; Region: COG1615 1138877008902 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 1138877008903 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 1138877008904 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 1138877008905 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1138877008906 Uncharacterized conserved protein [Function unknown]; Region: COG5282 1138877008907 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 1138877008908 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 1138877008909 ABC1 family; Region: ABC1; pfam03109 1138877008910 Phosphotransferase enzyme family; Region: APH; pfam01636 1138877008911 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1138877008912 active site 1138877008913 ATP binding site [chemical binding]; other site 1138877008914 Transcription factor WhiB; Region: Whib; pfam02467 1138877008915 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1138877008916 Part of AAA domain; Region: AAA_19; pfam13245 1138877008917 Family description; Region: UvrD_C_2; pfam13538 1138877008918 HRDC domain; Region: HRDC; pfam00570 1138877008919 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1138877008920 catalytic residues [active] 1138877008921 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 1138877008922 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 1138877008923 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 1138877008924 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1138877008925 putative NADH binding site [chemical binding]; other site 1138877008926 putative active site [active] 1138877008927 nudix motif; other site 1138877008928 putative metal binding site [ion binding]; other site 1138877008929 Ion channel; Region: Ion_trans_2; pfam07885 1138877008930 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1138877008931 TrkA-N domain; Region: TrkA_N; pfam02254 1138877008932 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1138877008933 Part of AAA domain; Region: AAA_19; pfam13245 1138877008934 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 1138877008935 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1138877008936 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1138877008937 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 1138877008938 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1138877008939 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1138877008940 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1138877008941 active site 1138877008942 DNA binding site [nucleotide binding] 1138877008943 TIGR02569 family protein; Region: TIGR02569_actnb 1138877008944 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 1138877008945 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1138877008946 ATP binding site [chemical binding]; other site 1138877008947 substrate interface [chemical binding]; other site 1138877008948 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1138877008949 active site residue [active] 1138877008950 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 1138877008951 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138877008952 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138877008953 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 1138877008954 tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like; Region: MiaE_2; pfam13794 1138877008955 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1138877008956 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1138877008957 ATP binding site [chemical binding]; other site 1138877008958 Mg++ binding site [ion binding]; other site 1138877008959 motif III; other site 1138877008960 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1138877008961 nucleotide binding region [chemical binding]; other site 1138877008962 ATP-binding site [chemical binding]; other site 1138877008963 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1138877008964 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1138877008965 P-loop; other site 1138877008966 Magnesium ion binding site [ion binding]; other site 1138877008967 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1138877008968 Magnesium ion binding site [ion binding]; other site 1138877008969 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1138877008970 catalytic core [active] 1138877008971 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 1138877008972 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1138877008973 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1138877008974 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1138877008975 Transcription factor WhiB; Region: Whib; pfam02467 1138877008976 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 1138877008977 PAS domain S-box; Region: sensory_box; TIGR00229 1138877008978 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1138877008979 Histidine kinase; Region: HisKA_2; pfam07568 1138877008980 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1138877008981 ATP binding site [chemical binding]; other site 1138877008982 Mg2+ binding site [ion binding]; other site 1138877008983 G-X-G motif; other site 1138877008984 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1138877008985 carboxyltransferase (CT) interaction site; other site 1138877008986 biotinylation site [posttranslational modification]; other site 1138877008987 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; TIGR03988 1138877008988 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 1138877008989 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1138877008990 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1138877008991 DNA binding residues [nucleotide binding] 1138877008992 short chain dehydrogenase; Provisional; Region: PRK08278 1138877008993 human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762 1138877008994 NAD(P) binding site [chemical binding]; other site 1138877008995 homodimer interface [polypeptide binding]; other site 1138877008996 active site 1138877008997 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 1138877008998 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 1138877008999 putative deacylase active site [active] 1138877009000 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1138877009001 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1138877009002 Coenzyme A binding pocket [chemical binding]; other site 1138877009003 Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases; Region: APH_ChoK_like_1; cd05155 1138877009004 Phosphotransferase enzyme family; Region: APH; pfam01636 1138877009005 putative active site [active] 1138877009006 putative substrate binding site [chemical binding]; other site 1138877009007 ATP binding site [chemical binding]; other site 1138877009008 Uncharacterized conserved protein [Function unknown]; Region: COG2135 1138877009009 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1138877009010 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1138877009011 hinge; other site 1138877009012 active site 1138877009013 Predicted GTPases [General function prediction only]; Region: COG1162 1138877009014 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1138877009015 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1138877009016 GTP/Mg2+ binding site [chemical binding]; other site 1138877009017 G4 box; other site 1138877009018 G5 box; other site 1138877009019 G1 box; other site 1138877009020 Switch I region; other site 1138877009021 G2 box; other site 1138877009022 G3 box; other site 1138877009023 Switch II region; other site 1138877009024 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1138877009025 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 1138877009026 putative di-iron ligands [ion binding]; other site 1138877009027 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 1138877009028 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1138877009029 FAD binding pocket [chemical binding]; other site 1138877009030 FAD binding motif [chemical binding]; other site 1138877009031 phosphate binding motif [ion binding]; other site 1138877009032 beta-alpha-beta structure motif; other site 1138877009033 NAD binding pocket [chemical binding]; other site 1138877009034 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1138877009035 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1138877009036 catalytic loop [active] 1138877009037 iron binding site [ion binding]; other site 1138877009038 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 1138877009039 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1138877009040 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1138877009041 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1138877009042 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1138877009043 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 1138877009044 TrkA-C domain; Region: TrkA_C; pfam02080 1138877009045 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1138877009046 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138877009047 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1138877009048 putative substrate translocation pore; other site 1138877009049 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1138877009050 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1138877009051 ligand binding site [chemical binding]; other site 1138877009052 flexible hinge region; other site 1138877009053 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1138877009054 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1138877009055 nucleophile elbow; other site 1138877009056 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1138877009057 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1138877009058 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1138877009059 30S subunit binding site; other site 1138877009060 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1138877009061 active site 1138877009062 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 1138877009063 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1138877009064 lipoprotein LpqB; Provisional; Region: PRK13616 1138877009065 Sporulation and spore germination; Region: Germane; pfam10646 1138877009066 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1138877009067 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1138877009068 dimerization interface [polypeptide binding]; other site 1138877009069 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1138877009070 dimer interface [polypeptide binding]; other site 1138877009071 phosphorylation site [posttranslational modification] 1138877009072 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1138877009073 ATP binding site [chemical binding]; other site 1138877009074 Mg2+ binding site [ion binding]; other site 1138877009075 G-X-G motif; other site 1138877009076 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1138877009077 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1138877009078 active site 1138877009079 phosphorylation site [posttranslational modification] 1138877009080 intermolecular recognition site; other site 1138877009081 dimerization interface [polypeptide binding]; other site 1138877009082 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1138877009083 DNA binding site [nucleotide binding] 1138877009084 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 1138877009085 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1138877009086 TMP-binding site; other site 1138877009087 ATP-binding site [chemical binding]; other site 1138877009088 Adenosylhomocysteinase; Provisional; Region: PTZ00075 1138877009089 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 1138877009090 homotetramer interface [polypeptide binding]; other site 1138877009091 ligand binding site [chemical binding]; other site 1138877009092 catalytic site [active] 1138877009093 NAD binding site [chemical binding]; other site 1138877009094 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138877009095 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 1138877009096 Rubredoxin [Energy production and conversion]; Region: COG1773 1138877009097 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1138877009098 iron binding site [ion binding]; other site 1138877009099 Rubredoxin [Energy production and conversion]; Region: COG1773 1138877009100 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1138877009101 iron binding site [ion binding]; other site 1138877009102 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 1138877009103 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1138877009104 Di-iron ligands [ion binding]; other site 1138877009105 amino acid transporter; Region: 2A0306; TIGR00909 1138877009106 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1138877009107 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1138877009108 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1138877009109 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1138877009110 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1138877009111 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1138877009112 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 1138877009113 active site 1138877009114 substrate binding site [chemical binding]; other site 1138877009115 metal binding site [ion binding]; metal-binding site 1138877009116 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 1138877009117 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 1138877009118 Transcription factor WhiB; Region: Whib; pfam02467 1138877009119 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 1138877009120 LPPG:FO 2-phospho-L-lactate transferase; important in F420 biosynthesis; Region: CofD_like; cd07186 1138877009121 phosphate binding site [ion binding]; other site 1138877009122 dimer interface [polypeptide binding]; other site 1138877009123 substrate binding site [chemical binding]; other site 1138877009124 F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294 1138877009125 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 1138877009126 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 1138877009127 putative FMN binding site [chemical binding]; other site 1138877009128 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 1138877009129 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1138877009130 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1138877009131 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 1138877009132 active site 1138877009133 Substrate binding site; other site 1138877009134 Mg++ binding site; other site 1138877009135 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1138877009136 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1138877009137 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1138877009138 Probable Catalytic site; other site 1138877009139 metal-binding site 1138877009140 dTDP-4-dehydrorhamnose reductase; Region: rmlD; TIGR01214 1138877009141 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1138877009142 NADP binding site [chemical binding]; other site 1138877009143 active site 1138877009144 putative substrate binding site [chemical binding]; other site 1138877009145 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1138877009146 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1138877009147 TIGR03089 family protein; Region: TIGR03089 1138877009148 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 1138877009149 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1138877009150 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1138877009151 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1138877009152 active site 1138877009153 motif I; other site 1138877009154 motif II; other site 1138877009155 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1138877009156 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1138877009157 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1138877009158 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1138877009159 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1138877009160 Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: CynT; COG0288 1138877009161 active site clefts [active] 1138877009162 zinc binding site [ion binding]; other site 1138877009163 dimer interface [polypeptide binding]; other site 1138877009164 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138877009165 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 1138877009166 FAD binding site [chemical binding]; other site 1138877009167 homotetramer interface [polypeptide binding]; other site 1138877009168 substrate binding pocket [chemical binding]; other site 1138877009169 catalytic base [active] 1138877009170 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1138877009171 Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase) [Nucleotide transport and metabolism]; Region: PurK; COG0026 1138877009172 ATP-grasp domain; Region: ATP-grasp; pfam02222 1138877009173 Predicted membrane protein [Function unknown]; Region: COG2246 1138877009174 GtrA-like protein; Region: GtrA; pfam04138 1138877009175 Bacterial PH domain; Region: DUF304; pfam03703 1138877009176 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1138877009177 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1138877009178 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1138877009179 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1138877009180 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1138877009181 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1138877009182 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 1138877009183 Maf-like protein; Region: Maf; pfam02545 1138877009184 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1138877009185 active site 1138877009186 dimer interface [polypeptide binding]; other site 1138877009187 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1138877009188 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1138877009189 active site residue [active] 1138877009190 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1138877009191 active site residue [active] 1138877009192 Fe-S metabolism associated domain; Region: SufE; pfam02657 1138877009193 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1138877009194 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1138877009195 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1138877009196 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1138877009197 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1138877009198 carboxyltransferase (CT) interaction site; other site 1138877009199 biotinylation site [posttranslational modification]; other site 1138877009200 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122 1138877009201 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1138877009202 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1138877009203 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1138877009204 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1138877009205 L-lysine aminotransferase; Provisional; Region: PRK08297 1138877009206 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1138877009207 inhibitor-cofactor binding pocket; inhibition site 1138877009208 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138877009209 catalytic residue [active] 1138877009210 putative DNA binding site [nucleotide binding]; other site 1138877009211 dimerization interface [polypeptide binding]; other site 1138877009212 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1138877009213 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1138877009214 putative Zn2+ binding site [ion binding]; other site 1138877009215 AsnC family; Region: AsnC_trans_reg; pfam01037 1138877009216 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 1138877009217 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 1138877009218 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1138877009219 tetrameric interface [polypeptide binding]; other site 1138877009220 NAD binding site [chemical binding]; other site 1138877009221 catalytic residues [active] 1138877009222 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 1138877009223 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138877009224 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138877009225 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1138877009226 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 1138877009227 ATP binding site [chemical binding]; other site 1138877009228 putative Mg++ binding site [ion binding]; other site 1138877009229 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1138877009230 nucleotide binding region [chemical binding]; other site 1138877009231 ATP-binding site [chemical binding]; other site 1138877009232 DEAD/H associated; Region: DEAD_assoc; pfam08494 1138877009233 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1138877009234 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 1138877009235 putative DNA binding site [nucleotide binding]; other site 1138877009236 catalytic residue [active] 1138877009237 putative H2TH interface [polypeptide binding]; other site 1138877009238 putative catalytic residues [active] 1138877009239 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1138877009240 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 1138877009241 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1138877009242 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1138877009243 Sulfatase; Region: Sulfatase; pfam00884 1138877009244 Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558 1138877009245 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1138877009246 probable active site [active] 1138877009247 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1138877009248 PhoU domain; Region: PhoU; pfam01895 1138877009249 PhoU domain; Region: PhoU; pfam01895 1138877009250 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1138877009251 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 1138877009252 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1138877009253 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1138877009254 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1138877009255 putative active site pocket [active] 1138877009256 dimerization interface [polypeptide binding]; other site 1138877009257 putative catalytic residue [active] 1138877009258 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1138877009259 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 1138877009260 metal binding site [ion binding]; metal-binding site 1138877009261 putative dimer interface [polypeptide binding]; other site 1138877009262 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 1138877009263 amidohydrolase; Region: amidohydrolases; TIGR01891 1138877009264 metal binding site [ion binding]; metal-binding site 1138877009265 purine nucleoside phosphorylase; Provisional; Region: PRK08202 1138877009266 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 1138877009267 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1138877009268 active site 1138877009269 substrate binding site [chemical binding]; other site 1138877009270 metal binding site [ion binding]; metal-binding site 1138877009271 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1138877009272 active site 1138877009273 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1138877009274 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138877009275 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1138877009276 adenosine deaminase; Provisional; Region: PRK09358 1138877009277 active site 1138877009278 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 1138877009279 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1138877009280 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1138877009281 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 1138877009282 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1138877009283 active site 1138877009284 catalytic motif [active] 1138877009285 Zn binding site [ion binding]; other site 1138877009286 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 1138877009287 putative Iron-sulfur protein interface [polypeptide binding]; other site 1138877009288 putative proximal heme binding site [chemical binding]; other site 1138877009289 putative SdhD-like interface [polypeptide binding]; other site 1138877009290 putative distal heme binding site [chemical binding]; other site 1138877009291 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 1138877009292 putative Iron-sulfur protein interface [polypeptide binding]; other site 1138877009293 putative proximal heme binding site [chemical binding]; other site 1138877009294 putative SdhC-like subunit interface [polypeptide binding]; other site 1138877009295 putative distal heme binding site [chemical binding]; other site 1138877009296 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 1138877009297 L-aspartate oxidase; Provisional; Region: PRK06175 1138877009298 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1138877009299 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 1138877009300 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1138877009301 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 1138877009302 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1138877009303 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138877009304 S-adenosylmethionine binding site [chemical binding]; other site 1138877009305 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1138877009306 MoaE interaction surface [polypeptide binding]; other site 1138877009307 MoeB interaction surface [polypeptide binding]; other site 1138877009308 thiocarboxylated glycine; other site 1138877009309 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1138877009310 MoaE homodimer interface [polypeptide binding]; other site 1138877009311 MoaD interaction [polypeptide binding]; other site 1138877009312 active site residues [active] 1138877009313 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1138877009314 trimer interface [polypeptide binding]; other site 1138877009315 dimer interface [polypeptide binding]; other site 1138877009316 putative active site [active] 1138877009317 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cl00942 1138877009318 Molybdenum cofactor biosynthesis enzyme [Coenzyme metabolism]; Region: MoaA; COG2896 1138877009319 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1138877009320 FeS/SAM binding site; other site 1138877009321 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1138877009322 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 1138877009323 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 1138877009324 DNA binding site [nucleotide binding] 1138877009325 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1138877009326 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1138877009327 phosphopeptide binding site; other site 1138877009328 Condensation domain; Region: Condensation; pfam00668 1138877009329 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1138877009330 Transposase; Region: HTH_Tnp_1; cl17663 1138877009331 putative transposase OrfB; Reviewed; Region: PHA02517 1138877009332 HTH-like domain; Region: HTH_21; pfam13276 1138877009333 Integrase core domain; Region: rve; pfam00665 1138877009334 Integrase core domain; Region: rve_3; pfam13683 1138877009335 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1138877009336 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1138877009337 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1138877009338 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1138877009339 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 1138877009340 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1138877009341 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1138877009342 DNA binding residues [nucleotide binding] 1138877009343 SnoaL-like domain; Region: SnoaL_2; pfam12680 1138877009344 hypothetical protein; Provisional; Region: PRK06541 1138877009345 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1138877009346 inhibitor-cofactor binding pocket; inhibition site 1138877009347 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138877009348 catalytic residue [active] 1138877009349 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1138877009350 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1138877009351 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 1138877009352 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138877009353 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1138877009354 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1138877009355 active site 1138877009356 dimer interface [polypeptide binding]; other site 1138877009357 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1138877009358 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 1138877009359 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1138877009360 DNA binding residues [nucleotide binding] 1138877009361 dimer interface [polypeptide binding]; other site 1138877009362 metal binding site [ion binding]; metal-binding site 1138877009363 inner membrane protein YhjD; Region: TIGR00766 1138877009364 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1138877009365 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1138877009366 active site 1138877009367 HIGH motif; other site 1138877009368 dimer interface [polypeptide binding]; other site 1138877009369 KMSKS motif; other site 1138877009370 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1138877009371 acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875 1138877009372 isocitrate dehydrogenase; Validated; Region: PRK08299 1138877009373 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 1138877009374 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1138877009375 homodimer interface [polypeptide binding]; other site 1138877009376 substrate-cofactor binding pocket; other site 1138877009377 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138877009378 catalytic residue [active] 1138877009379 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 1138877009380 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 1138877009381 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1138877009382 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138877009383 S-adenosylmethionine binding site [chemical binding]; other site 1138877009384 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138877009385 PPE family; Region: PPE; pfam00823 1138877009386 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138877009387 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1138877009388 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1138877009389 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1138877009390 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138877009391 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1138877009392 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1138877009393 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138877009394 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1138877009395 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1138877009396 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1138877009397 PE family; Region: PE; pfam00934 1138877009398 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 1138877009399 PPE family; Region: PPE; pfam00823 1138877009400 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1138877009401 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1138877009402 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138877009403 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1138877009404 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1138877009405 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138877009406 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1138877009407 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138877009408 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1138877009409 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1138877009410 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1138877009411 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1138877009412 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1138877009413 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1138877009414 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138877009415 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1138877009416 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1138877009417 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1138877009418 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1138877009419 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138877009420 PPE family; Region: PPE; pfam00823 1138877009421 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138877009422 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1138877009423 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1138877009424 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138877009425 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1138877009426 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1138877009427 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1138877009428 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1138877009429 Berberine and berberine like; Region: BBE; pfam08031 1138877009430 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1138877009431 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1138877009432 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 1138877009433 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 1138877009434 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1138877009435 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1138877009436 homodimer interface [polypeptide binding]; other site 1138877009437 NADP binding site [chemical binding]; other site 1138877009438 substrate binding site [chemical binding]; other site 1138877009439 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 1138877009440 Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769 1138877009441 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1138877009442 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 1138877009443 active site 1138877009444 FMN binding site [chemical binding]; other site 1138877009445 substrate binding site [chemical binding]; other site 1138877009446 putative catalytic residue [active] 1138877009447 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1138877009448 phosphate binding site [ion binding]; other site 1138877009449 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1138877009450 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1138877009451 phosphopeptide binding site; other site 1138877009452 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1138877009453 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1138877009454 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1138877009455 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1138877009456 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1138877009457 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 1138877009458 G1 box; other site 1138877009459 GTP/Mg2+ binding site [chemical binding]; other site 1138877009460 G2 box; other site 1138877009461 Switch I region; other site 1138877009462 G3 box; other site 1138877009463 Switch II region; other site 1138877009464 G4 box; other site 1138877009465 G5 box; other site 1138877009466 Protein of unknown function (DUF742); Region: DUF742; pfam05331 1138877009467 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 1138877009468 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1138877009469 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1138877009470 ATP binding site [chemical binding]; other site 1138877009471 Mg2+ binding site [ion binding]; other site 1138877009472 G-X-G motif; other site 1138877009473 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1138877009474 PE family; Region: PE; pfam00934 1138877009475 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 1138877009476 FMN binding site [chemical binding]; other site 1138877009477 dimer interface [polypeptide binding]; other site 1138877009478 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1138877009479 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 1138877009480 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1138877009481 active site 1138877009482 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1138877009483 generic binding surface II; other site 1138877009484 generic binding surface I; other site 1138877009485 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1138877009486 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1138877009487 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1138877009488 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 1138877009489 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1138877009490 active site 1138877009491 motif I; other site 1138877009492 motif II; other site 1138877009493 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138877009494 substrate binding site [chemical binding]; other site 1138877009495 oxyanion hole (OAH) forming residues; other site 1138877009496 trimer interface [polypeptide binding]; other site 1138877009497 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 1138877009498 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1138877009499 Amidase; Region: Amidase; pfam01425 1138877009500 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1138877009501 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1138877009502 motif II; other site 1138877009503 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 1138877009504 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 1138877009505 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1138877009506 TPP-binding site [chemical binding]; other site 1138877009507 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 1138877009508 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1138877009509 PYR/PP interface [polypeptide binding]; other site 1138877009510 dimer interface [polypeptide binding]; other site 1138877009511 TPP binding site [chemical binding]; other site 1138877009512 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1138877009513 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1138877009514 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1138877009515 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1138877009516 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1138877009517 substrate binding pocket [chemical binding]; other site 1138877009518 chain length determination region; other site 1138877009519 substrate-Mg2+ binding site; other site 1138877009520 catalytic residues [active] 1138877009521 aspartate-rich region 1; other site 1138877009522 active site lid residues [active] 1138877009523 aspartate-rich region 2; other site 1138877009524 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 1138877009525 putative active site [active] 1138877009526 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1138877009527 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 1138877009528 Transposase domain (DUF772); Region: DUF772; pfam05598 1138877009529 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 1138877009530 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1138877009531 PE family; Region: PE; pfam00934 1138877009532 enoyl-CoA hydratase; Region: PLN02864 1138877009533 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1138877009534 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 1138877009535 dimer interaction site [polypeptide binding]; other site 1138877009536 substrate-binding tunnel; other site 1138877009537 active site 1138877009538 catalytic site [active] 1138877009539 substrate binding site [chemical binding]; other site 1138877009540 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1138877009541 short chain dehydrogenase; Provisional; Region: PRK07201 1138877009542 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 1138877009543 putative NAD(P) binding site [chemical binding]; other site 1138877009544 active site 1138877009545 putative substrate binding site [chemical binding]; other site 1138877009546 classical (c) SDRs; Region: SDR_c; cd05233 1138877009547 NAD(P) binding site [chemical binding]; other site 1138877009548 active site 1138877009549 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1138877009550 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138877009551 S-adenosylmethionine binding site [chemical binding]; other site 1138877009552 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 1138877009553 active site 1138877009554 DNA Polymerase Y-family; Region: PolY_like; cd03468 1138877009555 DNA binding site [nucleotide binding] 1138877009556 GMP synthase; Reviewed; Region: guaA; PRK00074 1138877009557 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1138877009558 AMP/PPi binding site [chemical binding]; other site 1138877009559 candidate oxyanion hole; other site 1138877009560 catalytic triad [active] 1138877009561 potential glutamine specificity residues [chemical binding]; other site 1138877009562 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1138877009563 ATP Binding subdomain [chemical binding]; other site 1138877009564 Ligand Binding sites [chemical binding]; other site 1138877009565 Dimerization subdomain; other site 1138877009566 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 1138877009567 active site lid residues [active] 1138877009568 substrate binding pocket [chemical binding]; other site 1138877009569 catalytic residues [active] 1138877009570 substrate-Mg2+ binding site; other site 1138877009571 aspartate-rich region 1; other site 1138877009572 aspartate-rich region 2; other site 1138877009573 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1138877009574 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1138877009575 substrate binding pocket [chemical binding]; other site 1138877009576 chain length determination region; other site 1138877009577 substrate-Mg2+ binding site; other site 1138877009578 catalytic residues [active] 1138877009579 aspartate-rich region 1; other site 1138877009580 active site lid residues [active] 1138877009581 aspartate-rich region 2; other site 1138877009582 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138877009583 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1138877009584 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 1138877009585 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 1138877009586 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 1138877009587 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1138877009588 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1138877009589 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 1138877009590 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1138877009591 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1138877009592 inhibitor-cofactor binding pocket; inhibition site 1138877009593 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138877009594 catalytic residue [active] 1138877009595 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 1138877009596 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1138877009597 hypothetical protein; Provisional; Region: PRK07579 1138877009598 Formyltransferase, catalytic core domain; Region: FMT_core; cd08369 1138877009599 active site 1138877009600 cosubstrate binding site; other site 1138877009601 substrate binding site [chemical binding]; other site 1138877009602 catalytic site [active] 1138877009603 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138877009604 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138877009605 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1138877009606 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1138877009607 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1138877009608 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 1138877009609 putative active site [active] 1138877009610 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1138877009611 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1138877009612 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1138877009613 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 1138877009614 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1138877009615 phosphate binding site [ion binding]; other site 1138877009616 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1138877009617 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1138877009618 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1138877009619 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1138877009620 active site 1138877009621 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 1138877009622 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1138877009623 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1138877009624 DNA binding residues [nucleotide binding] 1138877009625 Transcription factor WhiB; Region: Whib; pfam02467 1138877009626 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1138877009627 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1138877009628 ring oligomerisation interface [polypeptide binding]; other site 1138877009629 ATP/Mg binding site [chemical binding]; other site 1138877009630 stacking interactions; other site 1138877009631 hinge regions; other site 1138877009632 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1138877009633 oligomerisation interface [polypeptide binding]; other site 1138877009634 mobile loop; other site 1138877009635 roof hairpin; other site 1138877009636 UGMP family protein; Validated; Region: PRK09604 1138877009637 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1138877009638 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1138877009639 Coenzyme A binding pocket [chemical binding]; other site 1138877009640 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 1138877009641 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; pfam02367 1138877009642 alanine racemase; Reviewed; Region: alr; PRK00053 1138877009643 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1138877009644 active site 1138877009645 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1138877009646 dimer interface [polypeptide binding]; other site 1138877009647 substrate binding site [chemical binding]; other site 1138877009648 catalytic residues [active] 1138877009649 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138877009650 PPE family; Region: PPE; pfam00823 1138877009651 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138877009652 PPE family; Region: PPE; pfam00823 1138877009653 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1138877009654 Integrase core domain; Region: rve; pfam00665 1138877009655 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 1138877009656 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138877009657 Walker A motif; other site 1138877009658 ATP binding site [chemical binding]; other site 1138877009659 Walker B motif; other site 1138877009660 arginine finger; other site 1138877009661 PE family; Region: PE; pfam00934 1138877009662 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138877009663 PPE family; Region: PPE; pfam00823 1138877009664 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1138877009665 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138877009666 PPE family; Region: PPE; pfam00823 1138877009667 Integrase core domain; Region: rve; pfam00665 1138877009668 Integrase core domain; Region: rve_3; pfam13683 1138877009669 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1138877009670 MULE transposase domain; Region: MULE; pfam10551 1138877009671 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 1138877009672 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138877009673 catalytic residue [active] 1138877009674 Uncharacterized conserved protein [Function unknown]; Region: COG0062 1138877009675 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1138877009676 putative substrate binding site [chemical binding]; other site 1138877009677 putative ATP binding site [chemical binding]; other site 1138877009678 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1138877009679 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1138877009680 glutaminase active site [active] 1138877009681 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1138877009682 dimer interface [polypeptide binding]; other site 1138877009683 active site 1138877009684 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1138877009685 dimer interface [polypeptide binding]; other site 1138877009686 active site 1138877009687 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 1138877009688 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 1138877009689 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1138877009690 active site 1138877009691 substrate binding site [chemical binding]; other site 1138877009692 metal binding site [ion binding]; metal-binding site 1138877009693 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1138877009694 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1138877009695 23S rRNA interface [nucleotide binding]; other site 1138877009696 L3 interface [polypeptide binding]; other site 1138877009697 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1138877009698 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1138877009699 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 1138877009700 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1138877009701 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1138877009702 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1138877009703 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1138877009704 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1138877009705 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 1138877009706 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 1138877009707 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1138877009708 active site 1138877009709 catalytic residues [active] 1138877009710 Protein of unknown function (DUF690); Region: DUF690; pfam05108 1138877009711 Cutinase; Region: Cutinase; pfam01083 1138877009712 Cutinase; Region: Cutinase; pfam01083 1138877009713 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1138877009714 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1138877009715 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1138877009716 active site 1138877009717 dimerization interface 3.5A [polypeptide binding]; other site 1138877009718 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1138877009719 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1138877009720 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1138877009721 alphaNTD - beta interaction site [polypeptide binding]; other site 1138877009722 alphaNTD homodimer interface [polypeptide binding]; other site 1138877009723 alphaNTD - beta' interaction site [polypeptide binding]; other site 1138877009724 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1138877009725 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1138877009726 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1138877009727 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1138877009728 RNA binding surface [nucleotide binding]; other site 1138877009729 30S ribosomal protein S11; Validated; Region: PRK05309 1138877009730 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1138877009731 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1138877009732 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 1138877009733 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1138877009734 rRNA binding site [nucleotide binding]; other site 1138877009735 predicted 30S ribosome binding site; other site 1138877009736 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 1138877009737 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 1138877009738 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1138877009739 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1138877009740 NAD binding site [chemical binding]; other site 1138877009741 substrate binding site [chemical binding]; other site 1138877009742 homodimer interface [polypeptide binding]; other site 1138877009743 active site 1138877009744 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 1138877009745 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1138877009746 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1138877009747 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1138877009748 active site 1138877009749 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1138877009750 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1138877009751 catalytic residues [active] 1138877009752 catalytic nucleophile [active] 1138877009753 Recombinase; Region: Recombinase; pfam07508 1138877009754 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 1138877009755 Protein of unknown function (DUF2742); Region: DUF2742; pfam10888 1138877009756 Phage associated DNA primase [General function prediction only]; Region: COG3378 1138877009757 D5 N terminal like; Region: D5_N; smart00885 1138877009758 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: COG3747 1138877009759 Phage head maturation protease [General function prediction only]; Region: COG3740 1138877009760 Predicted phage phi-C31 gp36 major capsid-like protein [General function prediction only]; Region: COG4653 1138877009761 Phage capsid family; Region: Phage_capsid; pfam05065 1138877009762 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1138877009763 extended (e) SDRs; Region: SDR_e; cd08946 1138877009764 NAD(P) binding site [chemical binding]; other site 1138877009765 active site 1138877009766 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 1138877009767 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 1138877009768 active site 1138877009769 catalytic residues [active] 1138877009770 metal binding site [ion binding]; metal-binding site 1138877009771 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 1138877009772 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1138877009773 PYR/PP interface [polypeptide binding]; other site 1138877009774 dimer interface [polypeptide binding]; other site 1138877009775 TPP binding site [chemical binding]; other site 1138877009776 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1138877009777 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1138877009778 TPP-binding site [chemical binding]; other site 1138877009779 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 1138877009780 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 1138877009781 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138877009782 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1138877009783 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138877009784 metabolite-proton symporter; Region: 2A0106; TIGR00883 1138877009785 putative substrate translocation pore; other site 1138877009786 PE family; Region: PE; pfam00934 1138877009787 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138877009788 PPE family; Region: PPE; pfam00823 1138877009789 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1138877009790 patatin-related protein; Region: TIGR03607 1138877009791 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1138877009792 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1138877009793 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 1138877009794 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 1138877009795 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 1138877009796 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 1138877009797 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1138877009798 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1138877009799 short chain dehydrogenase; Provisional; Region: PRK05875 1138877009800 classical (c) SDRs; Region: SDR_c; cd05233 1138877009801 NAD(P) binding site [chemical binding]; other site 1138877009802 active site 1138877009803 Predicted membrane protein [Function unknown]; Region: COG2259 1138877009804 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1138877009805 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1138877009806 Predicted transcriptional regulators [Transcription]; Region: COG1695 1138877009807 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1138877009808 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 1138877009809 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 1138877009810 active site 1138877009811 homotetramer interface [polypeptide binding]; other site 1138877009812 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138877009813 mce related protein; Region: MCE; pfam02470 1138877009814 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138877009815 mce related protein; Region: MCE; pfam02470 1138877009816 mce related protein; Region: MCE; pfam02470 1138877009817 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138877009818 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1138877009819 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138877009820 mce related protein; Region: MCE; pfam02470 1138877009821 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138877009822 mce related protein; Region: MCE; pfam02470 1138877009823 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138877009824 mce related protein; Region: MCE; pfam02470 1138877009825 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1138877009826 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1138877009827 Permease; Region: Permease; pfam02405 1138877009828 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1138877009829 Permease; Region: Permease; pfam02405 1138877009830 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07792 1138877009831 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138877009832 NAD(P) binding site [chemical binding]; other site 1138877009833 active site 1138877009834 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1138877009835 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 1138877009836 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138877009837 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 1138877009838 FAD binding site [chemical binding]; other site 1138877009839 substrate binding site [chemical binding]; other site 1138877009840 catalytic base [active] 1138877009841 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138877009842 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138877009843 active site 1138877009844 acyl-CoA synthetase; Validated; Region: PRK07867 1138877009845 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 1138877009846 acyl-activating enzyme (AAE) consensus motif; other site 1138877009847 putative AMP binding site [chemical binding]; other site 1138877009848 putative active site [active] 1138877009849 putative CoA binding site [chemical binding]; other site 1138877009850 PE family; Region: PE; pfam00934 1138877009851 PE family; Region: PE; pfam00934 1138877009852 hypothetical protein; Validated; Region: PRK07586 1138877009853 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1138877009854 PYR/PP interface [polypeptide binding]; other site 1138877009855 dimer interface [polypeptide binding]; other site 1138877009856 TPP binding site [chemical binding]; other site 1138877009857 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 1138877009858 TPP-binding site [chemical binding]; other site 1138877009859 dimer interface [polypeptide binding]; other site 1138877009860 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 1138877009861 PE family; Region: PE; pfam00934 1138877009862 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138877009863 CoA binding site [chemical binding]; other site 1138877009864 PE family; Region: PE; pfam00934 1138877009865 acyl-CoA synthetase; Validated; Region: PRK07798 1138877009866 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138877009867 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 1138877009868 acyl-activating enzyme (AAE) consensus motif; other site 1138877009869 acyl-activating enzyme (AAE) consensus motif; other site 1138877009870 putative AMP binding site [chemical binding]; other site 1138877009871 putative active site [active] 1138877009872 putative CoA binding site [chemical binding]; other site 1138877009873 enoyl-CoA hydratase; Provisional; Region: PRK07799 1138877009874 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138877009875 substrate binding site [chemical binding]; other site 1138877009876 oxyanion hole (OAH) forming residues; other site 1138877009877 trimer interface [polypeptide binding]; other site 1138877009878 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1138877009879 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138877009880 Cytochrome P450; Region: p450; cl12078 1138877009881 Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314 1138877009882 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1138877009883 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 1138877009884 DUF35 OB-fold domain; Region: DUF35; pfam01796 1138877009885 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1138877009886 DUF35 OB-fold domain; Region: DUF35; pfam01796 1138877009887 lipid-transfer protein; Provisional; Region: PRK07937 1138877009888 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1138877009889 active site 1138877009890 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1138877009891 active site 1138877009892 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1138877009893 NHL repeat; Region: NHL; pfam01436 1138877009894 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1138877009895 NHL repeat; Region: NHL; pfam01436 1138877009896 NHL repeat; Region: NHL; pfam01436 1138877009897 NHL repeat; Region: NHL; pfam01436 1138877009898 NHL repeat; Region: NHL; pfam01436 1138877009899 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1138877009900 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1138877009901 trimer interface [polypeptide binding]; other site 1138877009902 putative metal binding site [ion binding]; other site 1138877009903 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1138877009904 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 1138877009905 short chain dehydrogenase; Provisional; Region: PRK07890 1138877009906 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138877009907 NAD(P) binding site [chemical binding]; other site 1138877009908 active site 1138877009909 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138877009910 PPE family; Region: PPE; pfam00823 1138877009911 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1138877009912 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138877009913 PPE family; Region: PPE; pfam00823 1138877009914 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1138877009915 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1138877009916 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 1138877009917 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 1138877009918 active site 1138877009919 catalytic residues [active] 1138877009920 metal binding site [ion binding]; metal-binding site 1138877009921 DmpG-like communication domain; Region: DmpG_comm; pfam07836 1138877009922 acetaldehyde dehydrogenase; Validated; Region: PRK08300 1138877009923 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1138877009924 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 1138877009925 2-keto-4-pentenoate hydratase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3971 1138877009926 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843 1138877009927 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1138877009928 enoyl-CoA hydratase; Region: PLN02864 1138877009929 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1138877009930 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 1138877009931 dimer interaction site [polypeptide binding]; other site 1138877009932 substrate-binding tunnel; other site 1138877009933 active site 1138877009934 catalytic site [active] 1138877009935 substrate binding site [chemical binding]; other site 1138877009936 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138877009937 PPE family; Region: PPE; pfam00823 1138877009938 PE-PPE domain; Region: PE-PPE; pfam08237 1138877009939 lipid-transfer protein; Provisional; Region: PRK07855 1138877009940 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1138877009941 active site 1138877009942 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 1138877009943 putative active site [active] 1138877009944 putative catalytic site [active] 1138877009945 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1138877009946 active site 1138877009947 catalytic site [active] 1138877009948 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1138877009949 DUF35 OB-fold domain; Region: DUF35; pfam01796 1138877009950 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138877009951 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138877009952 active site 1138877009953 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138877009954 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1138877009955 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138877009956 active site 1138877009957 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138877009958 Cytochrome P450; Region: p450; cl12078 1138877009959 acetyl-CoA acetyltransferase; Provisional; Region: PRK07850 1138877009960 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1138877009961 dimer interface [polypeptide binding]; other site 1138877009962 active site 1138877009963 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1138877009964 short chain dehydrogenase; Provisional; Region: PRK07791 1138877009965 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 1138877009966 homodimer interface [polypeptide binding]; other site 1138877009967 NAD binding site [chemical binding]; other site 1138877009968 active site 1138877009969 short chain dehydrogenase; Provisional; Region: PRK07856 1138877009970 classical (c) SDRs; Region: SDR_c; cd05233 1138877009971 NAD(P) binding site [chemical binding]; other site 1138877009972 active site 1138877009973 enoyl-CoA hydratase; Provisional; Region: PRK06495 1138877009974 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138877009975 substrate binding site [chemical binding]; other site 1138877009976 oxyanion hole (OAH) forming residues; other site 1138877009977 trimer interface [polypeptide binding]; other site 1138877009978 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1138877009979 Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit [Lipid metabolism]; Region: AtoA; COG2057 1138877009980 Nitronate monooxygenase; Region: NMO; pfam03060 1138877009981 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1138877009982 FMN binding site [chemical binding]; other site 1138877009983 substrate binding site [chemical binding]; other site 1138877009984 putative catalytic residue [active] 1138877009985 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1138877009986 Beta-carotene hydroxylase (CrtR), the carotenoid zeaxanthin biosynthetic enzyme catalyzes the addition of hydroxyl groups to the beta-ionone rings of beta-carotene to form zeaxanthin and is found in bacteria and red algae. Carotenoids are important...; Region: CrtR_beta-carotene-hydroxylase; cd03514 1138877009987 putative di-iron ligands [ion binding]; other site 1138877009988 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 1138877009989 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 1138877009990 FAD binding pocket [chemical binding]; other site 1138877009991 FAD binding motif [chemical binding]; other site 1138877009992 phosphate binding motif [ion binding]; other site 1138877009993 beta-alpha-beta structure motif; other site 1138877009994 NAD(p) ribose binding residues [chemical binding]; other site 1138877009995 NAD binding pocket [chemical binding]; other site 1138877009996 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 1138877009997 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1138877009998 catalytic loop [active] 1138877009999 iron binding site [ion binding]; other site 1138877010000 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1138877010001 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1138877010002 putative active site [active] 1138877010003 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 1138877010004 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1138877010005 dimer interface [polypeptide binding]; other site 1138877010006 active site 1138877010007 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138877010008 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138877010009 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138877010010 PPE family; Region: PPE; pfam00823 1138877010011 short chain dehydrogenase; Provisional; Region: PRK07831 1138877010012 classical (c) SDRs; Region: SDR_c; cd05233 1138877010013 NAD(P) binding site [chemical binding]; other site 1138877010014 active site 1138877010015 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138877010016 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138877010017 active site 1138877010018 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 1138877010019 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138877010020 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 1138877010021 acyl-activating enzyme (AAE) consensus motif; other site 1138877010022 putative AMP binding site [chemical binding]; other site 1138877010023 putative active site [active] 1138877010024 putative CoA binding site [chemical binding]; other site 1138877010025 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138877010026 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138877010027 active site 1138877010028 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138877010029 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1138877010030 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138877010031 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138877010032 active site 1138877010033 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138877010034 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1138877010035 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138877010036 active site 1138877010037 aspartate aminotransferase; Provisional; Region: PRK05764 1138877010038 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1138877010039 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138877010040 homodimer interface [polypeptide binding]; other site 1138877010041 catalytic residue [active] 1138877010042 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 1138877010043 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1138877010044 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 1138877010045 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 1138877010046 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 1138877010047 active site 1138877010048 Fe binding site [ion binding]; other site 1138877010049 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 1138877010050 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138877010051 Naphthocyclinone hydroxylase; Region: NcnH; cd01159 1138877010052 Flavin binding site [chemical binding]; other site 1138877010053 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1138877010054 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 1138877010055 FAD binding pocket [chemical binding]; other site 1138877010056 FAD binding motif [chemical binding]; other site 1138877010057 phosphate binding motif [ion binding]; other site 1138877010058 beta-alpha-beta structure motif; other site 1138877010059 NAD(p) ribose binding residues [chemical binding]; other site 1138877010060 NAD binding pocket [chemical binding]; other site 1138877010061 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 1138877010062 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1138877010063 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1138877010064 catalytic loop [active] 1138877010065 iron binding site [ion binding]; other site 1138877010066 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138877010067 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138877010068 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138877010069 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138877010070 active site 1138877010071 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138877010072 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138877010073 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1138877010074 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1138877010075 DNA binding site [nucleotide binding] 1138877010076 domain linker motif; other site 1138877010077 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 1138877010078 putative dimerization interface [polypeptide binding]; other site 1138877010079 putative ligand binding site [chemical binding]; other site 1138877010080 PknH-like extracellular domain; Region: PknH_C; pfam14032 1138877010081 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1138877010082 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1138877010083 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1138877010084 transmembrane helices; other site 1138877010085 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1138877010086 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1138877010087 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1138877010088 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1138877010089 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1138877010090 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1138877010091 active site 1138877010092 HIGH motif; other site 1138877010093 nucleotide binding site [chemical binding]; other site 1138877010094 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1138877010095 KMSKS motif; other site 1138877010096 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1138877010097 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1138877010098 homotrimer interaction site [polypeptide binding]; other site 1138877010099 zinc binding site [ion binding]; other site 1138877010100 CDP-binding sites; other site 1138877010101 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1138877010102 substrate binding site; other site 1138877010103 dimer interface; other site 1138877010104 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 1138877010105 DNA repair protein RadA; Provisional; Region: PRK11823 1138877010106 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1138877010107 Walker A motif/ATP binding site; other site 1138877010108 ATP binding site [chemical binding]; other site 1138877010109 Walker B motif; other site 1138877010110 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1138877010111 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 1138877010112 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1138877010113 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 1138877010114 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 1138877010115 active site clefts [active] 1138877010116 zinc binding site [ion binding]; other site 1138877010117 dimer interface [polypeptide binding]; other site 1138877010118 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1138877010119 endonuclease III; Region: ENDO3c; smart00478 1138877010120 minor groove reading motif; other site 1138877010121 helix-hairpin-helix signature motif; other site 1138877010122 substrate binding pocket [chemical binding]; other site 1138877010123 active site 1138877010124 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1138877010125 PE family; Region: PE; pfam00934 1138877010126 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138877010127 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1138877010128 catalytic site [active] 1138877010129 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1138877010130 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 1138877010131 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1138877010132 Ami_2 domain; Region: Ami_2; smart00644 1138877010133 amidase catalytic site [active] 1138877010134 Zn binding residues [ion binding]; other site 1138877010135 substrate binding site [chemical binding]; other site 1138877010136 PE family; Region: PE; pfam00934 1138877010137 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1138877010138 Clp amino terminal domain; Region: Clp_N; pfam02861 1138877010139 Clp amino terminal domain; Region: Clp_N; pfam02861 1138877010140 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138877010141 Walker A motif; other site 1138877010142 ATP binding site [chemical binding]; other site 1138877010143 Walker B motif; other site 1138877010144 arginine finger; other site 1138877010145 UvrB/uvrC motif; Region: UVR; pfam02151 1138877010146 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138877010147 Walker A motif; other site 1138877010148 ATP binding site [chemical binding]; other site 1138877010149 Walker B motif; other site 1138877010150 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1138877010151 Lsr2; Region: Lsr2; pfam11774 1138877010152 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1138877010153 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1138877010154 dimer interface [polypeptide binding]; other site 1138877010155 putative anticodon binding site; other site 1138877010156 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1138877010157 motif 1; other site 1138877010158 dimer interface [polypeptide binding]; other site 1138877010159 active site 1138877010160 motif 2; other site 1138877010161 motif 3; other site 1138877010162 pantothenate kinase; Reviewed; Region: PRK13318 1138877010163 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1138877010164 tetramerization interface [polypeptide binding]; other site 1138877010165 active site 1138877010166 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1138877010167 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1138877010168 active site 1138877010169 ATP-binding site [chemical binding]; other site 1138877010170 pantoate-binding site; other site 1138877010171 HXXH motif; other site 1138877010172 Rossmann-like domain; Region: Rossmann-like; pfam10727 1138877010173 Uncharacterized conserved protein [Function unknown]; Region: COG5495 1138877010174 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 1138877010175 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 1138877010176 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1138877010177 catalytic center binding site [active] 1138877010178 ATP binding site [chemical binding]; other site 1138877010179 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1138877010180 homooctamer interface [polypeptide binding]; other site 1138877010181 active site 1138877010182 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1138877010183 dihydropteroate synthase; Region: DHPS; TIGR01496 1138877010184 substrate binding pocket [chemical binding]; other site 1138877010185 dimer interface [polypeptide binding]; other site 1138877010186 inhibitor binding site; inhibition site 1138877010187 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1138877010188 homodecamer interface [polypeptide binding]; other site 1138877010189 GTP cyclohydrolase I; Provisional; Region: PLN03044 1138877010190 active site 1138877010191 putative catalytic site residues [active] 1138877010192 zinc binding site [ion binding]; other site 1138877010193 GTP-CH-I/GFRP interaction surface; other site 1138877010194 FtsH Extracellular; Region: FtsH_ext; pfam06480 1138877010195 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1138877010196 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138877010197 Walker A motif; other site 1138877010198 ATP binding site [chemical binding]; other site 1138877010199 Walker B motif; other site 1138877010200 arginine finger; other site 1138877010201 Peptidase family M41; Region: Peptidase_M41; pfam01434 1138877010202 chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086 1138877010203 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 1138877010204 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138877010205 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1138877010206 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1138877010207 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1138877010208 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1138877010209 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1138877010210 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138877010211 PPE family; Region: PPE; pfam00823 1138877010212 PE family; Region: PE; pfam00934 1138877010213 Uncharacterized conserved protein [Function unknown]; Region: COG2968 1138877010214 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 1138877010215 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1138877010216 active site 1138877010217 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1138877010218 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1138877010219 Ligand Binding Site [chemical binding]; other site 1138877010220 Uncharacterized conserved protein [Function unknown]; Region: COG5282 1138877010221 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 1138877010222 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; pfam02113 1138877010223 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 1138877010224 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1138877010225 dimer interface [polypeptide binding]; other site 1138877010226 substrate binding site [chemical binding]; other site 1138877010227 metal binding sites [ion binding]; metal-binding site 1138877010228 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2899 1138877010229 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1138877010230 Ligand binding site; other site 1138877010231 Putative Catalytic site; other site 1138877010232 DXD motif; other site 1138877010233 Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034 1138877010234 Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5285 1138877010235 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1138877010236 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138877010237 NAD(P) binding site [chemical binding]; other site 1138877010238 active site 1138877010239 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1138877010240 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 1138877010241 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1138877010242 transposase; Provisional; Region: PRK06526 1138877010243 IstB-like ATP binding protein; Region: IstB_IS21; pfam01695 1138877010244 Walker B motif; other site 1138877010245 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1138877010246 MULE transposase domain; Region: MULE; pfam10551 1138877010247 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 1138877010248 Fic/DOC family; Region: Fic; cl00960 1138877010249 VbhA antitoxin and related proteins; Region: VbhA_like; cd11586 1138877010250 DNA polymerase III subunit delta'; Validated; Region: PRK07940 1138877010251 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1138877010252 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1138877010253 dimerization interface [polypeptide binding]; other site 1138877010254 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1138877010255 cyclase homology domain; Region: CHD; cd07302 1138877010256 nucleotidyl binding site; other site 1138877010257 metal binding site [ion binding]; metal-binding site 1138877010258 dimer interface [polypeptide binding]; other site 1138877010259 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 1138877010260 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1138877010261 active site 1138877010262 interdomain interaction site; other site 1138877010263 putative metal-binding site [ion binding]; other site 1138877010264 nucleotide binding site [chemical binding]; other site 1138877010265 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 1138877010266 domain I; other site 1138877010267 phosphate binding site [ion binding]; other site 1138877010268 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1138877010269 domain II; other site 1138877010270 domain III; other site 1138877010271 nucleotide binding site [chemical binding]; other site 1138877010272 DNA binding groove [nucleotide binding] 1138877010273 catalytic site [active] 1138877010274 domain IV; other site 1138877010275 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1138877010276 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1138877010277 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1138877010278 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1138877010279 DNA-binding site [nucleotide binding]; DNA binding site 1138877010280 RNA-binding motif; other site 1138877010281 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 1138877010282 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1138877010283 ATP binding site [chemical binding]; other site 1138877010284 putative Mg++ binding site [ion binding]; other site 1138877010285 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1138877010286 nucleotide binding region [chemical binding]; other site 1138877010287 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 1138877010288 PE family; Region: PE; pfam00934 1138877010289 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 1138877010290 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 1138877010291 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 1138877010292 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 1138877010293 Walker A motif; other site 1138877010294 hexamer interface [polypeptide binding]; other site 1138877010295 ATP binding site [chemical binding]; other site 1138877010296 Walker B motif; other site 1138877010297 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 1138877010298 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1138877010299 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1138877010300 motif II; other site 1138877010301 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1138877010302 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1138877010303 Walker A/P-loop; other site 1138877010304 ATP binding site [chemical binding]; other site 1138877010305 Q-loop/lid; other site 1138877010306 ABC transporter signature motif; other site 1138877010307 Walker B; other site 1138877010308 D-loop; other site 1138877010309 H-loop/switch region; other site 1138877010310 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1138877010311 Walker A/P-loop; other site 1138877010312 ATP binding site [chemical binding]; other site 1138877010313 Q-loop/lid; other site 1138877010314 ABC transporter signature motif; other site 1138877010315 Walker B; other site 1138877010316 D-loop; other site 1138877010317 H-loop/switch region; other site 1138877010318 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1138877010319 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1138877010320 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1138877010321 ABC-ATPase subunit interface; other site 1138877010322 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1138877010323 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1138877010324 dimer interface [polypeptide binding]; other site 1138877010325 conserved gate region; other site 1138877010326 ABC-ATPase subunit interface; other site 1138877010327 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1138877010328 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1138877010329 acetyl-CoA synthetase; Provisional; Region: PRK00174 1138877010330 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1138877010331 active site 1138877010332 CoA binding site [chemical binding]; other site 1138877010333 acyl-activating enzyme (AAE) consensus motif; other site 1138877010334 AMP binding site [chemical binding]; other site 1138877010335 acetate binding site [chemical binding]; other site 1138877010336 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 1138877010337 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138877010338 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1138877010339 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1138877010340 putative active site [active] 1138877010341 putative CoA binding site [chemical binding]; other site 1138877010342 nudix motif; other site 1138877010343 metal binding site [ion binding]; metal-binding site 1138877010344 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1138877010345 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1138877010346 catalytic residues [active] 1138877010347 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1138877010348 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1138877010349 minor groove reading motif; other site 1138877010350 helix-hairpin-helix signature motif; other site 1138877010351 substrate binding pocket [chemical binding]; other site 1138877010352 active site 1138877010353 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1138877010354 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1138877010355 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1138877010356 ligand binding site [chemical binding]; other site 1138877010357 flexible hinge region; other site 1138877010358 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1138877010359 putative switch regulator; other site 1138877010360 non-specific DNA interactions [nucleotide binding]; other site 1138877010361 DNA binding site [nucleotide binding] 1138877010362 sequence specific DNA binding site [nucleotide binding]; other site 1138877010363 putative cAMP binding site [chemical binding]; other site 1138877010364 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1138877010365 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 1138877010366 homotrimer interaction site [polypeptide binding]; other site 1138877010367 putative active site [active] 1138877010368 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 1138877010369 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 1138877010370 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1138877010371 P loop; other site 1138877010372 Nucleotide binding site [chemical binding]; other site 1138877010373 DTAP/Switch II; other site 1138877010374 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 1138877010375 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1138877010376 DTAP/Switch II; other site 1138877010377 Switch I; other site 1138877010378 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1138877010379 Transcription factor WhiB; Region: Whib; pfam02467 1138877010380 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1138877010381 Transglycosylase; Region: Transgly; pfam00912 1138877010382 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1138877010383 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1138877010384 phosphodiesterase YaeI; Provisional; Region: PRK11340 1138877010385 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1138877010386 putative active site [active] 1138877010387 putative metal binding site [ion binding]; other site 1138877010388 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1138877010389 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1138877010390 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1138877010391 catalytic residue [active] 1138877010392 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138877010393 Cytochrome P450; Region: p450; cl12078 1138877010394 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1138877010395 anti sigma factor interaction site; other site 1138877010396 regulatory phosphorylation site [posttranslational modification]; other site 1138877010397 Uncharacterized conserved protein [Function unknown]; Region: COG1610 1138877010398 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 1138877010399 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 1138877010400 MoxR-like ATPases [General function prediction only]; Region: COG0714 1138877010401 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138877010402 Walker A motif; other site 1138877010403 ATP binding site [chemical binding]; other site 1138877010404 Walker B motif; other site 1138877010405 arginine finger; other site 1138877010406 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1138877010407 Protein of unknown function DUF58; Region: DUF58; pfam01882 1138877010408 Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300 1138877010409 Predicted membrane protein/domain [Function unknown]; Region: COG1714 1138877010410 glycerol kinase; Provisional; Region: glpK; PRK00047 1138877010411 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1138877010412 nucleotide binding site [chemical binding]; other site 1138877010413 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 1138877010414 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 1138877010415 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1138877010416 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138877010417 S-adenosylmethionine binding site [chemical binding]; other site 1138877010418 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1138877010419 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1138877010420 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1138877010421 catalytic residue [active] 1138877010422 Uncharacterized conserved protein [Function unknown]; Region: COG4301 1138877010423 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 1138877010424 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 1138877010425 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1138877010426 putative active site [active] 1138877010427 putative dimer interface [polypeptide binding]; other site 1138877010428 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 1138877010429 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1138877010430 Gamma-glutamylcysteine synthetase [Coenzyme metabolism]; Region: GshA; COG3572 1138877010431 PknH-like extracellular domain; Region: PknH_C; pfam14032 1138877010432 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 1138877010433 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1138877010434 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1138877010435 aspartate kinase; Reviewed; Region: PRK06635 1138877010436 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1138877010437 putative nucleotide binding site [chemical binding]; other site 1138877010438 putative catalytic residues [active] 1138877010439 putative Mg ion binding site [ion binding]; other site 1138877010440 putative aspartate binding site [chemical binding]; other site 1138877010441 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1138877010442 putative allosteric regulatory site; other site 1138877010443 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1138877010444 putative allosteric regulatory residue; other site 1138877010445 2-isopropylmalate synthase; Validated; Region: PRK03739 1138877010446 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 1138877010447 active site 1138877010448 catalytic residues [active] 1138877010449 metal binding site [ion binding]; metal-binding site 1138877010450 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1138877010451 DNA polymerase III subunit epsilon; Provisional; Region: PRK06063 1138877010452 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1138877010453 active site 1138877010454 catalytic site [active] 1138877010455 substrate binding site [chemical binding]; other site 1138877010456 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 1138877010457 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 1138877010458 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1138877010459 catalytic triad [active] 1138877010460 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1138877010461 putative active site [active] 1138877010462 recombination protein RecR; Reviewed; Region: recR; PRK00076 1138877010463 RecR protein; Region: RecR; pfam02132 1138877010464 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1138877010465 putative active site [active] 1138877010466 putative metal-binding site [ion binding]; other site 1138877010467 tetramer interface [polypeptide binding]; other site 1138877010468 hypothetical protein; Validated; Region: PRK00153 1138877010469 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1138877010470 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1138877010471 active site 1138877010472 metal binding site [ion binding]; metal-binding site 1138877010473 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 1138877010474 hydrophobic ligand binding site; other site 1138877010475 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1138877010476 FAD binding domain; Region: FAD_binding_4; pfam01565 1138877010477 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1138877010478 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138877010479 S-adenosylmethionine binding site [chemical binding]; other site 1138877010480 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14952 1138877010481 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138877010482 Walker A motif; other site 1138877010483 ATP binding site [chemical binding]; other site 1138877010484 Walker B motif; other site 1138877010485 arginine finger; other site 1138877010486 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1138877010487 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 1138877010488 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1138877010489 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1138877010490 catalytic residue [active] 1138877010491 Cutinase; Region: Cutinase; pfam01083 1138877010492 Cutinase; Region: Cutinase; pfam01083 1138877010493 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138877010494 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1138877010495 NAD(P) binding site [chemical binding]; other site 1138877010496 active site 1138877010497 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1138877010498 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH8; cd08262 1138877010499 putative NAD(P) binding site [chemical binding]; other site 1138877010500 catalytic Zn binding site [ion binding]; other site 1138877010501 Uncharacterized conserved protein [Function unknown]; Region: COG3349 1138877010502 Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl17487 1138877010503 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1138877010504 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138877010505 putative substrate translocation pore; other site 1138877010506 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1138877010507 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1138877010508 ligand binding site [chemical binding]; other site 1138877010509 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1138877010510 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 1138877010511 active site 1138877010512 nucleophile elbow; other site 1138877010513 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG1964 1138877010514 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1138877010515 FeS/SAM binding site; other site 1138877010516 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1138877010517 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138877010518 S-adenosylmethionine binding site [chemical binding]; other site 1138877010519 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 1138877010520 nucleotide binding site [chemical binding]; other site 1138877010521 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 1138877010522 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 1138877010523 active site 1138877010524 DNA binding site [nucleotide binding] 1138877010525 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 1138877010526 DNA binding site [nucleotide binding] 1138877010527 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4402 1138877010528 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_5; cd04662 1138877010529 nudix motif; other site 1138877010530 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1138877010531 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1138877010532 Uncharacterized conserved protein [Function unknown]; Region: COG1839 1138877010533 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1138877010534 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1138877010535 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1138877010536 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1138877010537 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1138877010538 Uncharacterized conserved protein [Function unknown]; Region: COG3610 1138877010539 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138877010540 PPE family; Region: PPE; pfam00823 1138877010541 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138877010542 PPE family; Region: PPE; pfam00823 1138877010543 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1138877010544 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1138877010545 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1138877010546 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1138877010547 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 1138877010548 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 1138877010549 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1138877010550 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1138877010551 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1138877010552 dimerization interface [polypeptide binding]; other site 1138877010553 putative DNA binding site [nucleotide binding]; other site 1138877010554 putative Zn2+ binding site [ion binding]; other site 1138877010555 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3651 1138877010556 DNA binding domain, excisionase family; Region: excise; TIGR01764 1138877010557 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1138877010558 active site 1138877010559 Int/Topo IB signature motif; other site 1138877010560 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1138877010561 nucleoside/Zn binding site; other site 1138877010562 dimer interface [polypeptide binding]; other site 1138877010563 catalytic motif [active] 1138877010564 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 1138877010565 prephenate dehydrogenase; Validated; Region: PRK06545 1138877010566 prephenate dehydrogenase; Validated; Region: PRK08507 1138877010567 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3554 1138877010568 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1138877010569 ABC-ATPase subunit interface; other site 1138877010570 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 1138877010571 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1138877010572 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1138877010573 Walker A/P-loop; other site 1138877010574 ATP binding site [chemical binding]; other site 1138877010575 Q-loop/lid; other site 1138877010576 ABC transporter signature motif; other site 1138877010577 Walker B; other site 1138877010578 D-loop; other site 1138877010579 H-loop/switch region; other site 1138877010580 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1138877010581 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 1138877010582 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1138877010583 putative active site [active] 1138877010584 putative substrate binding site [chemical binding]; other site 1138877010585 ATP binding site [chemical binding]; other site 1138877010586 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 1138877010587 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1138877010588 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 1138877010589 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1138877010590 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 1138877010591 dimerization interface [polypeptide binding]; other site 1138877010592 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1138877010593 dimer interface [polypeptide binding]; other site 1138877010594 phosphorylation site [posttranslational modification] 1138877010595 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1138877010596 ATP binding site [chemical binding]; other site 1138877010597 Mg2+ binding site [ion binding]; other site 1138877010598 G-X-G motif; other site 1138877010599 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1138877010600 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1138877010601 active site 1138877010602 phosphorylation site [posttranslational modification] 1138877010603 intermolecular recognition site; other site 1138877010604 dimerization interface [polypeptide binding]; other site 1138877010605 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1138877010606 DNA binding site [nucleotide binding] 1138877010607 Photosystem II reaction centre W protein (PsbW); Region: PsbW; cl06243 1138877010608 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138877010609 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1138877010610 SnoaL-like domain; Region: SnoaL_2; pfam12680 1138877010611 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 1138877010612 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1138877010613 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138877010614 homodimer interface [polypeptide binding]; other site 1138877010615 catalytic residue [active] 1138877010616 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1138877010617 TIGR03086 family protein; Region: TIGR03086 1138877010618 enoyl-CoA hydratase; Provisional; Region: PRK06142 1138877010619 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138877010620 substrate binding site [chemical binding]; other site 1138877010621 oxyanion hole (OAH) forming residues; other site 1138877010622 trimer interface [polypeptide binding]; other site 1138877010623 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1138877010624 Beta-lactamase; Region: Beta-lactamase; pfam00144 1138877010625 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1138877010626 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1138877010627 active site 1138877010628 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 1138877010629 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 1138877010630 NAD(P) binding site [chemical binding]; other site 1138877010631 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1138877010632 cysteine desulfurase family protein, VC1184 subfamily; Region: am_tr_V_VC1184; TIGR01976 1138877010633 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1138877010634 catalytic residue [active] 1138877010635 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 1138877010636 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1138877010637 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1138877010638 Walker A/P-loop; other site 1138877010639 ATP binding site [chemical binding]; other site 1138877010640 Q-loop/lid; other site 1138877010641 ABC transporter signature motif; other site 1138877010642 Walker B; other site 1138877010643 D-loop; other site 1138877010644 H-loop/switch region; other site 1138877010645 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1138877010646 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1138877010647 active site 1138877010648 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1138877010649 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1138877010650 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1138877010651 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 1138877010652 NAD binding site [chemical binding]; other site 1138877010653 substrate binding site [chemical binding]; other site 1138877010654 active site 1138877010655 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1138877010656 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1138877010657 active site 1138877010658 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1138877010659 Peptidase family M23; Region: Peptidase_M23; pfam01551 1138877010660 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138877010661 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1138877010662 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05892 1138877010663 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1138877010664 Predicted membrane protein [Function unknown]; Region: COG2246 1138877010665 GtrA-like protein; Region: GtrA; pfam04138 1138877010666 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1138877010667 FAD binding domain; Region: FAD_binding_4; pfam01565 1138877010668 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 1138877010669 short chain dehydrogenase; Provisional; Region: PRK07904 1138877010670 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1138877010671 NAD(P) binding site [chemical binding]; other site 1138877010672 active site 1138877010673 Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250 1138877010674 Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249 1138877010675 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 1138877010676 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 1138877010677 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 1138877010678 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1138877010679 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 1138877010680 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138877010681 FAD binding site [chemical binding]; other site 1138877010682 substrate binding site [chemical binding]; other site 1138877010683 catalytic residues [active] 1138877010684 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1138877010685 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1138877010686 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1138877010687 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1138877010688 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1138877010689 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1138877010690 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1138877010691 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1138877010692 active site 1138877010693 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1138877010694 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1138877010695 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1138877010696 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1138877010697 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 1138877010698 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1138877010699 acyl-activating enzyme (AAE) consensus motif; other site 1138877010700 active site 1138877010701 Cutinase; Region: Cutinase; pfam01083 1138877010702 Predicted esterase [General function prediction only]; Region: COG0627 1138877010703 Putative esterase; Region: Esterase; pfam00756 1138877010704 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 1138877010705 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 1138877010706 active site 1138877010707 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1138877010708 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1138877010709 active site 1138877010710 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 1138877010711 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1138877010712 UDP-galactopyranose mutase; Region: GLF; pfam03275 1138877010713 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 1138877010714 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1138877010715 amidase catalytic site [active] 1138877010716 Zn binding residues [ion binding]; other site 1138877010717 substrate binding site [chemical binding]; other site 1138877010718 LGFP repeat; Region: LGFP; pfam08310 1138877010719 PE family; Region: PE; pfam00934 1138877010720 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1138877010721 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1138877010722 active site 1138877010723 motif I; other site 1138877010724 motif II; other site 1138877010725 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1138877010726 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1138877010727 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1138877010728 putative acyl-acceptor binding pocket; other site 1138877010729 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1138877010730 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1138877010731 putative acyl-acceptor binding pocket; other site 1138877010732 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1138877010733 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1138877010734 putative acyl-acceptor binding pocket; other site 1138877010735 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 1138877010736 Phosphotransferase enzyme family; Region: APH; pfam01636 1138877010737 active site 1138877010738 ATP binding site [chemical binding]; other site 1138877010739 antibiotic binding site [chemical binding]; other site 1138877010740 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1138877010741 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1138877010742 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1138877010743 iron-sulfur cluster [ion binding]; other site 1138877010744 [2Fe-2S] cluster binding site [ion binding]; other site 1138877010745 Condensation domain; Region: Condensation; pfam00668 1138877010746 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 1138877010747 PE-PPE domain; Region: PE-PPE; pfam08237 1138877010748 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1138877010749 Condensation domain; Region: Condensation; pfam00668 1138877010750 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1138877010751 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1138877010752 active site 1138877010753 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1138877010754 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1138877010755 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138877010756 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1138877010757 Enoylreductase; Region: PKS_ER; smart00829 1138877010758 NAD(P) binding site [chemical binding]; other site 1138877010759 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1138877010760 KR domain; Region: KR; pfam08659 1138877010761 putative NADP binding site [chemical binding]; other site 1138877010762 active site 1138877010763 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1138877010764 acyl-CoA synthetase; Validated; Region: PRK05850 1138877010765 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1138877010766 acyl-activating enzyme (AAE) consensus motif; other site 1138877010767 active site 1138877010768 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1138877010769 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1138877010770 Probable transposase; Region: OrfB_IS605; pfam01385 1138877010771 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 1138877010772 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 1138877010773 catalytic residues [active] 1138877010774 catalytic nucleophile [active] 1138877010775 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1138877010776 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1138877010777 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1138877010778 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138877010779 Protein of unknown function (DUF2834); Region: DUF2834; pfam11196 1138877010780 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138877010781 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1138877010782 Cupin domain; Region: Cupin_2; cl17218 1138877010783 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1138877010784 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1138877010785 seryl-tRNA synthetase; Provisional; Region: PRK05431 1138877010786 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1138877010787 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1138877010788 dimer interface [polypeptide binding]; other site 1138877010789 active site 1138877010790 motif 1; other site 1138877010791 motif 2; other site 1138877010792 motif 3; other site 1138877010793 Septum formation; Region: Septum_form; pfam13845 1138877010794 Septum formation; Region: Septum_form; pfam13845 1138877010795 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 1138877010796 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1138877010797 catalytic core [active] 1138877010798 prephenate dehydratase; Provisional; Region: PRK11898 1138877010799 Prephenate dehydratase; Region: PDT; pfam00800 1138877010800 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1138877010801 putative L-Phe binding site [chemical binding]; other site 1138877010802 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1138877010803 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1138877010804 Ferritin-like domain; Region: Ferritin; pfam00210 1138877010805 ferroxidase diiron center [ion binding]; other site 1138877010806 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582 1138877010807 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 1138877010808 putative active site [active] 1138877010809 catalytic site [active] 1138877010810 putative metal binding site [ion binding]; other site 1138877010811 Domain of unknown function (DUF4328); Region: DUF4328; pfam14219 1138877010812 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1138877010813 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1138877010814 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1138877010815 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1138877010816 Predicted membrane protein [Function unknown]; Region: COG2119 1138877010817 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 1138877010818 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 1138877010819 Fimbrial protein; Region: Fimbrial; cl01416 1138877010820 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 1138877010821 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1138877010822 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1138877010823 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138877010824 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138877010825 hypothetical protein; Provisional; Region: PRK07945 1138877010826 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 1138877010827 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 1138877010828 active site 1138877010829 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 1138877010830 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1138877010831 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1138877010832 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1138877010833 active site 1138877010834 dimer interface [polypeptide binding]; other site 1138877010835 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1138877010836 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1138877010837 active site 1138877010838 FMN binding site [chemical binding]; other site 1138877010839 substrate binding site [chemical binding]; other site 1138877010840 3Fe-4S cluster binding site [ion binding]; other site 1138877010841 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1138877010842 domain interface; other site 1138877010843 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1138877010844 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1138877010845 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 1138877010846 EspG family; Region: ESX-1_EspG; pfam14011 1138877010847 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 1138877010848 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138877010849 Walker A motif; other site 1138877010850 ATP binding site [chemical binding]; other site 1138877010851 Walker B motif; other site 1138877010852 arginine finger; other site 1138877010853 Protein of unknown function (DUF690); Region: DUF690; pfam05108 1138877010854 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1138877010855 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1138877010856 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1138877010857 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1138877010858 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1138877010859 PE family; Region: PE; pfam00934 1138877010860 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138877010861 PPE family; Region: PPE; pfam00823 1138877010862 Proteins of 100 residues with WXG; Region: WXG100; cl02005 1138877010863 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1138877010864 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1138877010865 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 1138877010866 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 1138877010867 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 1138877010868 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1138877010869 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 1138877010870 active site 1138877010871 catalytic residues [active] 1138877010872 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 1138877010873 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 1138877010874 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138877010875 Walker A motif; other site 1138877010876 ATP binding site [chemical binding]; other site 1138877010877 Walker B motif; other site 1138877010878 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 1138877010879 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1138877010880 active site 1138877010881 catalytic residues [active] 1138877010882 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 1138877010883 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1138877010884 EspG family; Region: ESX-1_EspG; pfam14011 1138877010885 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1138877010886 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1138877010887 PPE family; Region: PPE; pfam00823 1138877010888 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1138877010889 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1138877010890 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1138877010891 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1138877010892 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1138877010893 Protein of unknown function (DUF690); Region: DUF690; pfam05108 1138877010894 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1138877010895 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1138877010896 catalytic residue [active] 1138877010897 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 1138877010898 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1138877010899 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 1138877010900 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1138877010901 active site 1138877010902 NTP binding site [chemical binding]; other site 1138877010903 metal binding triad [ion binding]; metal-binding site 1138877010904 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1138877010905 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1138877010906 Zn2+ binding site [ion binding]; other site 1138877010907 Mg2+ binding site [ion binding]; other site 1138877010908 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1138877010909 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1138877010910 active site 1138877010911 Ap6A binding site [chemical binding]; other site 1138877010912 nudix motif; other site 1138877010913 metal binding site [ion binding]; metal-binding site 1138877010914 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 1138877010915 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1138877010916 RNA polymerase sigma factor SigM; Reviewed; Region: PRK09643 1138877010917 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1138877010918 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1138877010919 DNA binding residues [nucleotide binding] 1138877010920 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1138877010921 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1138877010922 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1138877010923 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1138877010924 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1138877010925 catalytic residues [active] 1138877010926 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1138877010927 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1138877010928 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1138877010929 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1138877010930 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1138877010931 active site 1138877010932 metal binding site [ion binding]; metal-binding site 1138877010933 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1138877010934 ParB-like nuclease domain; Region: ParB; smart00470 1138877010935 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1138877010936 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1138877010937 P-loop; other site 1138877010938 Magnesium ion binding site [ion binding]; other site 1138877010939 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1138877010940 Magnesium ion binding site [ion binding]; other site 1138877010941 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 1138877010942 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 1138877010943 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 1138877010944 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1138877010945 G-X-X-G motif; other site 1138877010946 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 1138877010947 RxxxH motif; other site 1138877010948 putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449 1138877010949 Uncharacterized conserved protein [Function unknown]; Region: COG0759 1138877010950 ribonuclease P; Reviewed; Region: rnpA; PRK00588 1138877010951 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399