-- dump date 20111121_013428 -- class Genbank::CDS -- table cds -- table main -- field 1 id -- field 2 GI -- field 3 GeneID -- field 4 chrom_position -- field 5 chromosome -- field 6 codon_start -- field 7 contig -- field 8 description -- field 9 end_pos -- field 10 gene -- field 11 gene_id -- field 12 name -- field 13 organism -- field 14 product -- field 15 protein_id -- field 16 start_pos -- field 17 strand -- field 18 taxid -- field 19 type -- header -- id GI GeneID chrom_position chromosome codon_start contig description end_pos gene gene_id name organism product protein_id start_pos strand taxid type YP_025523.1 49146085 2846617 1..1107 1 NC_005916.1 MUP001, rep, len: 368 aa. Probable rep, similar to the Rep proteins on several Mycobacterial plasmids e.g. O32860 Rep of the plasmid pJAZ38 from Mycobacterium fortuitum (see Gavigan et al., 1997) (368 aa), fasta scores: opt: 1692, E(): 1.7e-96, (68.306% identity in 366 aa overlap); and Q938A1 RepA of the plasmid pVT2 from Mycobacterium avium (391 aa), fasta scores: opt: 1283, E(): 2.6e-71, (55.556% identity in 360 aa overlap); and Q48888 Rep of the plasmid pLR7 from Mycobacterium avium (360 aa). Also weakly similar to Q9ZHK2 Putative replication protein of the plasmid pSOX from Rhodococcus sp. X309 (368 aa), fasta scores: opt: 272, E(): 4.1e-09, (36.022% identity in 372 aa overlap). Contains Prosite match to entry PS50310 Alanine-rich region.; replication protein Rep 1107 rep 2846617 rep Mycobacterium ulcerans Agy99 replication protein Rep YP_025523.1 1 D 362242 CDS YP_025524.1 49146086 2846606 complement(1117..1431) 1 NC_005916.1 MUP002c, -, len: 104 aa. Hypothetical protein.; hypothetical protein 1431 2846606 MUP002c Mycobacterium ulcerans Agy99 hypothetical protein YP_025524.1 1117 R 362242 CDS YP_025525.1 49146087 2846561 1694..2290 1 NC_005916.1 MUP003, -, len: 198 aa. Hypothetical protein. Contains a helix turn helix motif between aa 30->51, Standard_deviations: 4.86, score 1665.00.; hypothetical protein 2290 2846561 MUP003 Mycobacterium ulcerans Agy99 hypothetical protein YP_025525.1 1694 D 362242 CDS YP_025526.1 49146088 2846562 complement(2310..2924) 1 NC_005916.1 MUP004c, -, len: 204 aa. Hypothetical protein. An alternative start site exists at nt 2588.; hypothetical protein 2924 2846562 MUP004c Mycobacterium ulcerans Agy99 hypothetical protein YP_025526.1 2310 R 362242 CDS YP_025527.1 49146089 2846551 complement(2921..3901) 1 NC_005916.1 MUP005c, parA, len: 326 aa. Possible parA, chromosome partitioning protein, similar to several e.g. O05189|PARA_CAUCR Chromosome partitioning protein parA from Caulobacter crescentus (267 aa), fasta scores: opt: 279, E(): 4.3e-10, (29.918% identity in 244 aa overlap); Q8G6J3|AAN24469 Chromosome partitioning protein P from Bifidobacterium longum (336 aa), fasta scores: opt: 324, E(): 7.3e-13, (30.085% identity in 236 aa overlap) and Q8KBD6 ATPase, ParA family from Chlorobium tepidum (265 aa), fasta scores: opt: 285, E(): 1.8e-10, (28.807% identity in 243 aa overlap). Contains a Pfam match to entry PF00991, ParA family ATPase.; chromosome partitioning protein ParA 3901 parA 2846551 parA Mycobacterium ulcerans Agy99 chromosome partitioning protein ParA YP_025527.1 2921 R 362242 CDS YP_025528.1 49146090 2846563 complement(5640..6386) 1 NC_005916.1 MUP006c, -, len: 248 aa. Hypothetical protein.; hypothetical protein 6386 2846563 MUP006c Mycobacterium ulcerans Agy99 hypothetical protein YP_025528.1 5640 R 362242 CDS YP_025529.1 49146091 2846564 complement(6383..6604) 1 NC_005916.1 MUP007c, -, len: 73 aa. Conserved hypothetical protein, some similarity to O33270|Rv0340 Hypothetical protein from M. tuberculosis (179 aa), fasta scores: opt: 88, E(): 21, (32.558% identity in 43 aa overlap); and Q8KKW1 Hypothetical protein on the symbiotic plasmid p42d from Rhizobium etli (108 aa), fasta scores: opt: 92, E(): 7.1, (58.333% identity in 24 aa overlap); and O52677 Core protein (Fragment) from Escherichia coli (193 aa), fasta scores: opt: 91, E(): 13, (31.818% identity in 66 aa overlap).; hypothetical protein 6604 2846564 MUP007c Mycobacterium ulcerans Agy99 hypothetical protein YP_025529.1 6383 R 362242 CDS YP_025530.1 49146092 2846618 complement(6612..7160) 1 NC_005916.1 MUP008c, -, len: 182 aa. Possible nucleic acid binding protein, similar to the C-terminus of several N utilization substance proteins e.g. O05818|NUSA_MYCTU|Rv2841c N utilization substance protein A from M. tuberculosis (347 aa), fasta scores: opt: 337, E(): 6.5e-14, (42.143% identity in 140 aa overlap); Q9HV54 N utilization substance protein A from Pseudomonas aeruginosa (493 aa), fasta scores: opt: 353, E(): 7.9e-15, (38.255% identity in 149 aa overlap); etc. Contains a possible Pfam match to entry PF00013 KH domain.; nucleic acid binding protein 7160 2846618 MUP008c Mycobacterium ulcerans Agy99 nucleic acid binding protein YP_025530.1 6612 R 362242 CDS YP_025531.1 49146093 2846574 7188..7616 1 NC_005916.1 MUP009, -, 142 aa. Hypothetical protein.; hypothetical protein 7616 2846574 MUP009 Mycobacterium ulcerans Agy99 hypothetical protein YP_025531.1 7188 D 362242 CDS YP_025532.1 49146094 2846575 7630..8421 1 NC_005916.1 MUP010, -, len: 263 aa. Hypothetical protein.; hypothetical protein 8421 2846575 MUP010 Mycobacterium ulcerans Agy99 hypothetical protein YP_025532.1 7630 D 362242 CDS YP_025533.1 49146095 2846552 8430..10412 1 NC_005916.1 MUP011, pknQ, len: 660 aa. Probable pknQ, transmembrane serine/threonine-protein kinase (EC 2.7.1.-), similar to several mycobacterial serine/threonine-protein kinases e.g. Q10697|PKNJ_MYCTU|Rv2088 from M. tuberculosis (589 aa), fasta scores: opt: 1121, E(): 2.9e-43, (43.45% identity in 527 aa overlap); P72003|PKNF_MYCTU|Rv1746 from M. tuberculosis (476 aa), fasta scores: opt: 761, E(): 4.2e-27, (38.661% identity in 463 aa overlap); Q9RLQ7 Putative serine/threonine protein kinase from M. bovis (291 aa), etc. And similar to serine/threonine-protein kinases from other bacteria e.g. Q9XA16 Putative serine/threonine protein kinase from Streptomyces coelicolor (673 aa), fasta scores: opt: 656, E(): 2.9e-22 (36.164% identity in 365 aa overlap). Contains a Prosite matches to entries PS50011 Protein kinase domain and PS00108, Serine/Threonine protein kinases active-site signature pattern. Belongs to the SER/THR family of protein kinases.; transmembrane serine/threonine-protein kinase PknQ 10412 pknQ 2846552 pknQ Mycobacterium ulcerans Agy99 transmembrane serine/threonine-protein kinase PknQ YP_025533.1 8430 D 362242 CDS YP_025534.1 49146096 2846576 complement(10429..10692) 1 NC_005916.1 MUP012c, -, len: 87 aa. Hypothetical protein. Some similarity to Antigen 84 from M. tuberculosis and M. leprae e.g. P46816|AG84_MYCTU|Rv2145c Antigen 84 from M. tuberculosis (260 aa), fasta scores: opt: 105, E(): 4.1, (36.735% identity in 49 aa overlap).; hypothetical protein 10692 2846576 MUP012c Mycobacterium ulcerans Agy99 hypothetical protein YP_025534.1 10429 R 362242 CDS YP_025535.1 49146097 2846612 complement(10689..11147) 1 NC_005916.1 MUP013c, -, len: 152 aa. Possible conserved membrane protein, some similarity to Q8EX03 Putative integral membrane protein from Mycoplasma penetrans (303 aa), fasta scores: opt: 106, E(): 14, (31.250% identity in 96 aa overlap). Contains two membrane spanning regions towards the N-terminus.; hypothetical protein 11147 2846612 MUP013c Mycobacterium ulcerans Agy99 hypothetical protein YP_025535.1 10689 R 362242 CDS YP_025536.1 49146098 2846613 complement(11149..11922) 1 NC_005916.1 MUP014c, -, len: 257 aa. Putative integral membrane protein, contains several membrane spanning regions. An alternative start codon exists downstream.; putative integral membrane protein 11922 2846613 MUP014c Mycobacterium ulcerans Agy99 putative integral membrane protein YP_025536.1 11149 R 362242 CDS YP_025537.1 49146099 2846614 complement(11916..12692) 1 NC_005916.1 MUP015c, -, len: 258 aa. Possible secreted protein, contains probable N-terminal signal sequence.; hypothetical protein 12692 2846614 MUP015c Mycobacterium ulcerans Agy99 hypothetical protein YP_025537.1 11916 R 362242 CDS YP_025538.1 49146100 2846615 complement(12689..13480) 1 NC_005916.1 MUP016c, -, len: 263 aa. Hypothetical protein. Contains a Prosite match to entry PS00152 ATPASE_ALPHA_BETA ATP synthase alpha and beta subunits signature; hypothetical protein 13480 2846615 MUP016c Mycobacterium ulcerans Agy99 hypothetical protein YP_025538.1 12689 R 362242 CDS YP_025539.1 49146101 2846616 complement(13477..13929) 1 NC_005916.1 MUP017c, -, len: 150 aa. Possible conserved transmembrane protein, weakly similar to O06254|Rv3437 possible conserved transmembrane protein from M. tuberculosis (158 aa), fasta scores: opt: 244, E(): 2.3e-05, (38.393% identity in 112 aa overlap). Contains a Prosite match to entry PS50099 PRO_RICH Proline-rich region. Contains hydrophobic region at the C-terminus.; transmembrane protein 13929 2846616 MUP017c Mycobacterium ulcerans Agy99 transmembrane protein YP_025539.1 13477 R 362242 CDS YP_025540.1 49146102 2846607 complement(13973..15061) 1 NC_005916.1 MUP018c, -, len: 362 aa. Probable forkhead-associated protein, similar to several other M. tuberculosis conserved hypothetical ala-rich proteins e.g. P96214|Rv3863 Hypothetical protein (392 aa), fasta scores: opt: 525, E(): 1.9e-25, (33.602% identity in 372 aa overlap); O50389|Rv3360 Hypothetical protein (122 aa), fasta scores: opt: 198, E(): 3.4e-05, (37.113% identity in 97 aa overlap); and similar to the N-terminus of O65934|Rv1747 hypothetical 92.2 kDa protein (ABC transporter, ATP-binding protein (865 aa), fasta scores: opt: 207, E(): 4.3e-05, (37.255% identity in 102 aa overlap). Contains a Prosite match to entries PS50006 FHA_DOMAIN Forkhead-associated (FHA) domain and PS50310 ALA_RICH Alanine-rich region. And a Pfam match to entry PF01381 HTH_3, Helix-turn-helix.; forkhead-associated protein 15061 2846607 MUP018c Mycobacterium ulcerans Agy99 forkhead-associated protein YP_025540.1 13973 R 362242 CDS YP_025541.1 49146103 2846608 15406..16440 1 NC_005916.1 MUP019, -, len: 344 aa. Probable conserved membrane protein, weakly similar to several membrane associated proteins from M. tuberculosis e.g. to the C-terminus of two probable serine/threonine-protein kinases Q11053|PKNH_MYCTU|Rv1266c (626 aa), fasta scores: opt: 483, E(): 3.7e-16, (29.032% identity in 341 aa overlap); and PKNJ_MYCTU|Q10697|Rv2088 (589 aa), fasta scores: opt: 315, E(): 5.4e-08, (25.649% identity in 308 aa overlap). Also weakly similar to P96858|Rv3576 Possible lipoprotein lppH from M. tuberculosis (237 aa), fasta scores: opt: 380, E(): 1.9e-11, (29.918% identity in 244 aa overlap). Contains a Prosite match to entry PS50099 PRO_RICH Proline-rich region. Contains a membrane spanning region between aa 102 to 124.; hypothetical protein 16440 2846608 MUP019 Mycobacterium ulcerans Agy99 hypothetical protein YP_025541.1 15406 D 362242 CDS YP_025542.1 49146104 2846609 16430..16612 1 NC_005916.1 MUP020, -, len: 60 aa. Conserved hypothetical protein, some similarity to Q983E1 Hypothetical protein mll8367 from Rhizobium loti (Mesorhizobium loti) (91 aa), fasta scores: opt: 92, E(): 4.5, (35.00% identity in 40 aa overlap).; hypothetical protein 16612 2846609 MUP020 Mycobacterium ulcerans Agy99 hypothetical protein YP_025542.1 16430 D 362242 CDS YP_025543.1 49146105 2846610 16609..16872 1 NC_005916.1 MUP021, -, len: 87 aa. Possible transcriptional regulatory protein, similar to other possible WhiB-like regulatory proteins e.g. O69649|Rv3681c Probable whiB4 from M. tuberculosis (118 aa), fasta scores: opt: 141, E(): 0.001, (44.681% identity in 47 aa overlap); P96215|Rv3862c Possible whiB6 from M. tuberculosis (116 aa), fasta scores: opt: 133, E(): 0.0054, (29.412% identity in 85 aa overlap). Also weakly similar to other putative regulatory proteins e.g. Q9S2B9 Putative regulatory protein from Streptomyces coelicolor (112 aa), fasta scores: opt: 115, E(): 0.11, (34.211% identity in 76 aa overlap). Contains a Pfam match to entry PF02467 Transcription factor WhiB.; transcriptional regulatory protein 16872 2846610 MUP021 Mycobacterium ulcerans Agy99 transcriptional regulatory protein YP_025543.1 16609 D 362242 CDS YP_025544.1 49146106 2846611 17287..18621 1 NC_005916.1 MUP022, -, len: 444 aa. Probable transposase for IS2606, highly similar to Q9ZG97 Probable transposase from M. ulcerans (444 aa), fasta scores: opt: 2409, E(): 5.3e-154, (97.872% identity in 376 aa overlap); and similar to O05912 Hypothetical 48.7 kDa protein (IS1554, transposase) from M. tuberculosis (439 aa), fasta scores: opt: 1675, E(): 1.1e-104, (68.564% identity in 369 aa overlap).; transposase for the insertion element IS2606 18621 2846611 MUP022 Mycobacterium ulcerans Agy99 transposase for the insertion element IS2606 YP_025544.1 17287 D 362242 CDS YP_025545.1 49146107 2846553 complement(18772..19404) 1 NC_005916.1 MUP023c, -, len: 210 aa. Hypothetical protein.; hypothetical protein 19404 2846553 MUP023c Mycobacterium ulcerans Agy99 hypothetical protein YP_025545.1 18772 R 362242 CDS YP_025546.1 49146108 2846554 complement(19401..19988) 1 NC_005916.1 MUP024c, -, len: 195 aa. Hypothetical protein.; hypothetical protein 19988 2846554 MUP024c Mycobacterium ulcerans Agy99 hypothetical protein YP_025546.1 19401 R 362242 CDS YP_025547.1 49146109 2846555 20718..22457 1 NC_005916.1 MUP025, -, len: 579 aa. Putative transposase, weakly similar to several putative transposases e.g. Q8R6J9 Transposase from Thermoanaerobacter tengcongensis (565 aa), fasta scores: opt: 315, E(): 5.2e-13, (22.095% identity in 525 aa overlap); O70063 Putative transposase from Mycobacterium smegmatis (503 aa), fasta scores: opt: 221, E(): 9.3e-07, (26.190% identity in 504 aa overlap); Q9Z681 Transposase from Mycoplasma mycoides subsp. mycoides SC (483 aa), fasta scores: opt: 221, E(): 9e-07, (23.288% identity in 365 aa overlap). Almost identical to MUP028 and highly similar to MUP037 but longer.; putative transposase 22457 2846555 MUP025 Mycobacterium ulcerans Agy99 putative transposase YP_025547.1 20718 D 362242 CDS YP_025548.1 49146110 2846556 22629..23963 1 NC_005916.1 MUP026, -, len: 444 aa. Probable transposase for IS2606, highly similar to Q9ZG97 Probable transposase from M. ulcerans (444 aa), fasta scores: opt: 2874, E(): 3.8e-192, (98.423% identity in 444 aa overlap); and similar to O05912 Hypothetical 48.7 kDa protein (IS1554, transposase) from M. tuberculosis (439 aa), fasta scores: opt: 2063, E(): 1.1e-135, (71.034% identity in 435 aa overlap).; transposase for the insertion element IS2606 23963 2846556 MUP026 Mycobacterium ulcerans Agy99 transposase for the insertion element IS2606 YP_025548.1 22629 D 362242 CDS YP_025549.1 49146111 2846538 complement(24162..24980) 1 NC_005916.1 MUP027c, -, len: 272 aa. Putative transposase, similar to several putative transposases e.g. P71924|Rv2424c Probable transposase for IS1558 from Mycobacterium tuberculosis (333 aa), fasta scores: opt: 755, E(): 1.7e-42, (45.118% identity in 297 aa overlap); Q8RAU1 Transposase from Thermoanaerobacter tengcongensis (405 aa), fasta scores: opt: 756, E(): 1.7e-42, (42.517% identity in 294 aa overlap). Contains a Pfam match to entry PF02371, Transposase IS116/IS110/IS902 family.; putative transposase 24980 2846538 MUP027c Mycobacterium ulcerans Agy99 putative transposase YP_025549.1 24162 R 362242 CDS YP_025550.1 49146112 2846539 complement(25197..26936) 1 NC_005916.1 MUP028c, -, len: 579 aa. Putative transposase, weakly similar to several putative transposases e.g. Q8R6J9 Transposase from Thermoanaerobacter tengcongensis (565 aa), fasta scores: opt: 315, E(): 6.8e-13, (22.095% identity in 525 aa overlap); O70063 Putative transposase from Mycobacterium smegmatis (503 aa), fasta scores: opt: 221, E(): 1.1e-06, (26.190% identity in 504 aa overlap); Q9Z681 Transposase from Mycoplasma mycoides subsp. mycoides SC (483 aa), fasta scores: opt: 221, E(): 1.1e-06, (23.288% identity in 365 aa overlap). Almost identical to MUP025 and highly similar to MUP037 but longer.; putative transposase 26936 2846539 MUP028c Mycobacterium ulcerans Agy99 putative transposase YP_025550.1 25197 R 362242 CDS YP_025551.1 49146113 2846540 complement(26980..27321) 1 NC_005916.1 MUP029c, -, len: 113 aa. Probable IS2404 transposase fragment, highly similar to the C-terminus of O07439 Putative transposase from Mycobacterium ulcerans (327 aa), fasta scores: opt: 496, E(): 3.7e-31, (94.805% identity in 77 aa overlap). Note that this homology extends across the upstream TAG stop codon into the upstream MUP030, suggesting a possible readthrough of the previous stop codon. No sequence errors have been identified and this insertion sequence containing the internal stop codon is repeated at two other locations on the plasmid, MUP047 + MUP048 and MUP062 + MUP063.; transposase for the insertion element IS2404 (fragment) 27321 2846540 MUP029c Mycobacterium ulcerans Agy99 transposase for the insertion element IS2404 (fragment) YP_025551.1 26980 R 362242 CDS YP_025552.1 49146114 2846541 complement(27322..28026) 1 NC_005916.1 MUP030c, -, len: 234 aa. Probable IS2404 transposase fragment, highly similar to O07439 Putative transposase from Mycobacterium ulcerans (327 aa), fasta scores: opt: 1839, E(): 2.4e-119, (92.949% identity in 312 aa overlap). Note that this homology extends across the stop codon and directly into MUP029, suggesting a possible readthrough of the TAG stop codon. No sequence errors have been identified and this insertion sequence containing the internal stop codon is repeated at two other locations on the plasmid, MUP047 + MUP048 and MUP062 + MUP063.; transposase for the insertion element IS2404 (fragment) 28026 2846541 MUP030c Mycobacterium ulcerans Agy99 transposase for the insertion element IS2404 (fragment) YP_025552.1 27322 R 362242 CDS YP_025553.1 49146115 2846542 complement(28386..29720) 1 NC_005916.1 MUP031c, -, len: 444 aa. Probable transposase for IS2606, highly similar to Q9ZG97 Probable transposase from Mycobacterium ulcerans (444 aa), fasta scores: opt: 2879, E(): 6.2e-188, (98.423% identity in 444 aa overlap); and to O05912 Hypothetical 48.7 kDa protein (IS1554, transposase) from M. tuberculosis (439 aa), fasta scores: opt: 2055, E(): 5e-132, (70.805% identity in 435 aa overlap).; transposase for the insertion element IS2606 29720 2846542 MUP031c Mycobacterium ulcerans Agy99 transposase for the insertion element IS2606 YP_025553.1 28386 R 362242 CDS YP_025554.1 49146116 2846550 complement(30054..72446) 1 NC_005916.1 MUP032c, mlsB, len: 14130 aa. Type I modular polyketide synthase, composed of a loading module and seven extender modules; required for the synthesis of the mycolactone side-chain in M. ulcerans (see Stinear et al., 2003). Similar to the modules in several other bacterial polyketide synthases e.g. Q93NX9 AmphI from Streptomyces nodosus (9510 aa), fasta scores: opt: 10163, E(): 0, (41.418% identity in 10394 aa overlap); Q9ALM3 Polyketide synthase extender modules 5-7 from Saccharopolyspora spinosa (4928 aa), fasta scores: opt: 8980, E(): 0, (46.330% identity in 4945 aa overlap); Q93HJ2 Modular polyketide synthase from Streptomyces avermitilis (4685 aa), fasta scores: opt: 5558, E(): 0, (44.649% identity in 4934 aa overlap). Contains 8 x Pfam matches to entry PF00109 ketoacyl-synt: Beta-ketoacyl synthase, N-terminal domain and 8 x Pfam matches to entry PF02801 ketoacyl-synt_C: Beta-ketoacyl synthase, C-terminal domain. Contains 8 x Pfam matches to entry PF00550 pp-binding: Phosphopantetheine attachment site and 8 x Pfam matches to entry PF00698 Acyl_transf: Acyl transferase domain.; Type I modular polyketide synthase 72446 mlsB 2846550 mlsB Mycobacterium ulcerans Agy99 Type I modular polyketide synthase YP_025554.1 30054 R 362242 CDS YP_025555.1 49146117 2846557 complement(72536..72910) 1 NC_005916.1 MUP033c, -, len: 124 aa. Putative transposase, similar in part to several transposases e.g. BAC67824 Putative transposase from Streptomyces avermitilis (239 aa), fasta scores: opt: 263, E(): 3.7e-12, (50.617% identity in 81 aa overlap); Q8KRD5 ISRh1 transposase-like protein from Rhodococcus erythropolis (236 aa), fasta score: opt: 257, E(): 1e-11, (64.286% identity in 56 aa overlap); Q982I3 Transposase from plasmid pMLa of Rhizobium loti (Mesorhizobium loti) (185 aa), fasta scores: opt: 200, E(): 1.6e-07, (37.209% identity in 86 aa overlap). Highly similar to MUP041.; putative transposase 72910 2846557 MUP033c Mycobacterium ulcerans Agy99 putative transposase YP_025555.1 72536 R 362242 CDS YP_025556.1 49146118 2846558 complement(73008..73547) 1 NC_005916.1 MUP034c, -, len: 179 aa. Putative transposase, weakly similar to several transposases from Xanthomonas e.g. Q8NL03 ISxac2 transposase from plasmid pXAC33 and pXAC64 of Xanthomonas axonopodis (275 aa), fasta scores: opt: 214, E(): 5.5e-07, (33.766% identity in 146 aa overlap); Q8PCU3 ISxcC1 transposase from Xanthomonas campestris (255 aa), fasta scores: opt: 198, E(): 3.8e-06, (34.286% identity in 105 aa overlap). Also weakly similar to Q9X9H9 IS1400 transposase B from Yersinia enterocolitica (294 aa), fasta scores: opt: 202, E(): 2.8e-06, (38.095% identity in 105 aa overlap). Almost identical to MUP042. Contains a Pfam match to entry PF00665 rve Integrase core domain.; putative transposase 73547 2846558 MUP034c Mycobacterium ulcerans Agy99 putative transposase YP_025556.1 73008 R 362242 CDS YP_025557.1 49146119 2846559 74138..74851 1 NC_005916.1 MUP035, -, len: 237 aa. Putative transposase, similar to several transposases from Streptomyces e.g. BAC68344|Q82Q86 Putative transposase from Streptomyces avermitilis (354 aa), fasta scores: opt: 551, E(): 5.1e-23, (52.299% identity in 174 aa overlap); O69923 Putative transposase from Streptomyces coelicolor (379 aa), fasta score: opt: 309, E(): 7.6e-10, (35.897% identity in 195 aa overlap). And also weakly similar to BAC18219|Q8FPT1 Putative transposase from Corynebacterium efficiens (446 aa), fasta scores: opt: 435, E(): 8.5e-17, (39.487% identity in 195 aa overlap);and O07182|Rv0797 Putative transposase of IS1547 from M. tuberculosis (364 aa), fasta scores: opt: 225, E(): 3.5e-05, (31.818% identity in 154 aa overlap). Highly similar to MUP043 but shorter. Contains a Pfam match to entry PF01548 Transposase_9, Transposase.; putative transposase 74851 2846559 MUP035 Mycobacterium ulcerans Agy99 putative transposase YP_025557.1 74138 D 362242 CDS YP_025558.1 49146120 2846560 complement(74905..76239) 1 NC_005916.1 MUP036c, -, len: 444 aa. Probable transposase for IS2606, highly similar to Q9ZG97 Probable transposase from Mycobacterium ulcerans (444 aa), fasta scores: opt: 2878, E(): 5.8e-191, (98.198% identity in 444 aa overlap); and to O05912 Hypothetical 48.7 kDa protein (IS1554, transposase) from M. tuberculosis (439 aa), fasta scores: opt: 2042, E(): 2.3e-134, (71.628% identity in 435 aa overlap).; transposase for the insertion element IS2606 76239 2846560 MUP036c Mycobacterium ulcerans Agy99 transposase for the insertion element IS2606 YP_025558.1 74905 R 362242 CDS YP_025559.1 49146121 2846569 76556..77911 1 NC_005916.1 MUP037, -, len: 451. Putative transposase, weakly similar to several transposases from Thermoanaerobacter tengcongensis e.g. Q8R7J7 Transposase (565 aa), fasta scores: opt: 296, E(): 1.8e-10, (22.826% identity in 368 aa overlap); and Q8R6J9 Transposase (565 aa), fasta scores: opt: 292, E(): 3.5e-10, (22.283% identity in 368 aa overlap). And also weakly similar to O70063 Putative transposase from Mycobacterium smegmatis (503 aa), fasta scores: opt: 203, E(): 9.1e-05, (26.790% identity in 377 aa overlap). And highly similar to MUP025 and MUP028 but shorter.; putative transposase 77911 2846569 MUP037 Mycobacterium ulcerans Agy99 putative transposase YP_025559.1 76556 D 362242 CDS YP_025560.1 49146122 2846570 complement(78019..78924) 1 NC_005916.1 MUP038c, -, len: 301 aa. Possible thioesterase, similar to AAO65353|Q84CJ0 LanU-like protein from Streptomyces murayamaensis (249 aa), fasta scores: opt: 558, E(): 6.4e-30, (37.945% identity in 253 aa overlap); and weakly similar to weakly similar to Q98NH0 Lactone-specific esterase from Rhizobium loti (Mesorhizobium loti) (334 aa), fasta scores: opt: 175, E(): 0.00037, (23.675% identity in 283 aa overlap); Q9CD03|ML2603 Hypothetical protein from M. leprae (279 aa), fasta scores: opt: 153, E(): 0.0099, (33.051% identity in 118 aa overlap); Q9XAK3|SCO3599 Hypothetical protein from Streptomyces coelicolor (318 aa), fasta scores: opt: 160, E(): 0.0037, (28.261% identity in 276 aa overlap); and Q8PQF3 Hydrolase from Xanthomonas axonopodis (280 aa), fasta scores: opt: 158, E(): 0.0045, (30.769% identity in 130 aa overlap). Contains potential match to Pfam PF02230 Phospholipase/Carboxylesterase, Pfam PF00561 alpha/beta hydrolase fold.; thioesterase 78924 2846570 MUP038c Mycobacterium ulcerans Agy99 thioesterase YP_025560.1 78019 R 362242 CDS YP_025561.1 49146123 2846549 complement(79080..86312) 1 NC_005916.1 MUP039c, mlsA2, len: 2410 aa. Type I modular polyketide synthase, composed of one extender module (module 9); required for the synthesis of the mycolactone core in M. ulcerans (see Stinear et al., 2003). Similar to part of several e.g. Q9S0R8 Type I polyketide synthase AVES 1 from Streptomyces avermitilis (3972 aa), fasta scores: opt: 3342, E(): 2.1e-187, (40.556% identity in 2160 aa overlap); Q93NW8 AmphA from Streptomyces nodosus (1412 aa), fasta scores: opt: 3171, E(): 9.9e-178, (47.163% identity in 1304 aa overlap). Contains a Pfam match to entry PF00109 ketoacyl-synt: Beta-ketoacyl synthase, N-terminal domain and a Pfam match to entry PF02801 ketoacyl-synt_C: Beta-ketoacyl synthase, C-terminal domain. Contains a Pfam match entry PF00550 pp-binding: Phosphopantetheine attachment site and a Pfam match to entry PF00698 Acyl_transf: Acyl transferase domain.; Type I modular polyketide synthase 86312 mlsA2 2846549 mlsA2 Mycobacterium ulcerans Agy99 Type I modular polyketide synthase YP_025561.1 79080 R 362242 CDS YP_025562.1 49146124 2846548 complement(86299..137271) 1 NC_005916.1 MUP040c, mlsA1, len: 16990 aa. Type I modular polyketide synthase, composed of a loading module and eight extender modules; required for the synthesis of the mycolactone core in M. ulcerans (see Stinear et al., 2003). Similar to the modules in several other bacterial polyketide synthases e.g. O33954 Tylactone synthase starter module and modules 1 & 2 from Streptomyces fradiae (4472 aa), fasta scores: opt: 5121, E(): 0, (41.958% identity in 4066 aa overlap); Q9ALM3 Polyketide synthase extender modules 5-7 from Saccharopolyspora spinosa (4928 aa), fasta scores: opt: 4860, E(): 0, (41.813% identity in 5515 aa overlap); and Q9ADL6 Soraphen polyketide synthase A from Polyangium cellulosum (6315 aa), fasta scores: opt: 4448, E(): 0, (39.533% identity in 6420 aa overlap). Contains 9 x Pfam matches to entry PF00109 ketoacyl-synt: Beta-ketoacyl synthase, N-terminal domain and 9 x Pfam match to entry PF02801 ketoacyl-synt_C: Beta-ketoacyl synthase, C-terminal domain. Contains 9 x Pfam match entry PF00550 pp-binding: Phosphopantetheine attachment site and 9 x Pfam match to entry PF00698 Acyl_transf: Acyl transferase domain.; Type I modular polyketide synthase 137271 mlsA1 2846548 mlsA1 Mycobacterium ulcerans Agy99 Type I modular polyketide synthase YP_025562.1 86299 R 362242 CDS YP_025563.1 49146125 2846571 complement(137361..137735) 1 NC_005916.1 MUP041c, -, len: 124 aa. Putative transposase, similar in part to several transposases e.g. BAC67824 Putative transposase from Streptomyces avermitilis (239 aa), fasta scores: opt: 263, E(): 3.7e-12, (50.617% identity in 81 aa overlap); Q8KRD5 ISRh1 transposase-like protein from Rhodococcus erythropolis (236 aa), fasta score: opt: 257, E(): 9e-12, (64.286% identity in 56 aa overlap); Q982I3 Transposase from plasmid pMLa of Rhizobium loti (Mesorhizobium loti) (185 aa), fasta scores: opt: 200, E(): 1.5e-07, (37.209% identity in 86 aa overlap). Highly similar to MUP033.; putative transposase 137735 2846571 MUP041c Mycobacterium ulcerans Agy99 putative transposase YP_025563.1 137361 R 362242 CDS YP_025564.1 49146126 2846572 complement(137833..138372) 1 NC_005916.1 MUP042c, -, len: 179 aa. Putative transposase, weakly similar to several transposases from Xanthomonas e.g. Q8NL03 ISxac2 transposase from Xanthomonas axonopodis (275 aa), opt: 212, E(): 3.8e-07, (33.562% identity in 146 aa overlap); Q8PCU3 ISxcC1 transposase from Xanthomonas campestris (255 aa), fasta scores: opt: 198, E(): 3.4e-06, (34.286% identity in 105 aa overlap). Also weakly similar to Q9X9H9 IS1400 transposase B from Yersinia enterocolitica (294 aa), fasta scores: opt: 202, E(): 2e-06, (38.095% identity in 105 aa overlap). Almost identical to MUP034. Contains a Pfam match to entry PF00665 rve Integrase core domain.; putative transposase 138372 2846572 MUP042c Mycobacterium ulcerans Agy99 putative transposase YP_025564.1 137833 R 362242 CDS YP_025565.1 49146127 2846573 138963..140018 1 NC_005916.1 MUP043, -, len: 351 aa. Putative transposase, similar to several putative transposases from Streptomyces e.g BAC68344|Q82Q86 Putative transposase from Streptomyces avermitilis (354 aa), fasta scores: opt: 1146, E(): 1.1e-63, (52.493% identity in 341 aa overlap); O69923 Putative transposase from Streptomyces coelicolor (379 aa), fasta scores: opt: 742, E(): 1.5e-38, (39.339% identity in 333 aa overlap). And similar to transposases from Corynebacterium efficiens e.g. BAC18308|Q8FTR3 Putative transposase (409 aa), fasta scores: opt: 993, E(): 4e-54, (45.210% identity in 334 aa overlap); BAC17059|Q8CMH0 Putative transposase (412 aa), fasta scores: opt: 947, E(): 2.9e-51, (43.413% identity in 334 aa overlap). Also weakly similar to Q8VJ30 IS1547, transposase from M. tuberculosis (596 aa), fasta scores: opt: 474, E(): 7.4e-22, (35.347% identity in 350 aa overlap). Contains a Pfam match to entry PF02371, Transposase_20, Transposase IS116/IS110/IS902 family. Highly similar to MUP035 but longer.; putative transposase 140018 2846573 MUP043 Mycobacterium ulcerans Agy99 putative transposase YP_025565.1 138963 D 362242 CDS YP_025566.1 49146128 2846596 complement(140008..140148) 1 NC_005916.1 MUP044c, -, len: 46 aa. Putative truncated transposase, similar to several transposases from Xanthomonas e.g. Q8P9Q3 IS1477 transposase from Xanthomonas campestris (88 aa), fasta scores: opt: 106, E(): 0.2, (55.882% identity in 34 aa overlap); and Q8PRI1 ISxac2 transposase from Xanthomonas axonopodis (88 aa), fasta scores: opt: 104, E(): 0.29, (48.571% identity in 35 aa overlap). And some similarity to MUP051.; transposase 140148 2846596 MUP044c Mycobacterium ulcerans Agy99 transposase YP_025566.1 140008 R 362242 CDS YP_025567.1 49146129 2846597 140606..141592 1 NC_005916.1 MUP045, -, len: 328 aa. Probable beta-ketoacyl synthase-like protein, weakly similar to Q9KHD3 Type III beta-ketoacyl synthase-like protein from Streptomyces griseus subsp. griseus (345 aa), fasta scores: opt: 238, E(): 1e-07, (26.282% identity in 312 aa overlap). Most similar to Q54816 Daunorubicin-doxorubicin polyketide synthase from Streptomyces peucetius (353 aa), fasta scores: opt: 301, E(): 9.1e-12, (31.672% identity in 341 aa overlap); and also similar to several 3-oxoacyl-(acyl-carrier-protein) synthases e.g. Q9A8I4 3-oxoacyl-(acyl-carrier-protein) synthase III from Caulobacter crescentus (322 aa), fasta scores: opt: 259, E(): 4.3e-09, (26.935% identity in 323 aa overlap).; beta-ketoacyl synthase-like protein 141592 2846597 MUP045 Mycobacterium ulcerans Agy99 beta-ketoacyl synthase-like protein YP_025567.1 140606 D 362242 CDS YP_025568.1 49146130 2846598 142322..142615 1 NC_005916.1 MUP046, -, len: 97 aa. Possible membrane protein, some similarity to Q92RR3 Hypothetical protein R00794 from Rhizobium meliloti (275 aa), E(): 26, (36.634% identity in 101 aa overlap). Contains a membrane spanning region between aa 24 to 46.; hypothetical protein 142615 2846598 MUP046 Mycobacterium ulcerans Agy99 hypothetical protein YP_025568.1 142322 D 362242 CDS YP_025569.1 49146131 2846599 143012..143716 1 NC_005916.1 MUP047, -, len: 234 aa. Probable IS2404 transposase fragment, highly similar to O07439 Putative transposase from Mycobacterium ulcerans (327 aa), fasta scores: opt: 1339, E(): 5.2e-84, (91.880% identity in 234 aa overlap). Note that this homology extends across the stop codon and directly into MUP048, suggesting a possible readthrough of the TAG stop codon. No sequence errors have been identified and this insertion sequence containing the internal stop codon is repeated at two other locations on the plasmid, MUP029 + MUP030 and MUP062 + MUP063.; transposase for the insertion element IS2404 (fragment) 143716 2846599 MUP047 Mycobacterium ulcerans Agy99 transposase for the insertion element IS2404 (fragment) YP_025569.1 143012 D 362242 CDS YP_025570.1 49146132 2846600 143717..144058 1 NC_005916.1 MUP048, -, len: 113 aa. Probable IS2404 transposase fragment, highly similar to the C-terminus of O07439 Putative transposase from M. ulcerans (327 aa), fasta scores: opt: 496, E(): 6.8e-31, (94.80% identity in 77 aa overlap). Note that this homology extends across the upstream TAG stop codon into the upstream MUP047, suggesting a possible readthrough of the previous stop codon. No sequence errors have been identified and this insertion sequence containing the internal stop codon is repeated at two other locations on the plasmid, MUP029 + MUP030 and MUP062 + MUP063.; transposase for the insertion element IS2404 (fragment) 144058 2846600 MUP048 Mycobacterium ulcerans Agy99 transposase for the insertion element IS2404 (fragment) YP_025570.1 143717 D 362242 CDS YP_025571.1 49146133 2846543 complement(144304..144693) 1 NC_005916.1 MUP049c, -, len: 129 aa. Putative transposase, similar to several e.g. Q54335 Similar to ORF1 of the IS3 family from Streptomyces lividans (103 aa), fasta scores: opt: 225, E(): 2.9e-07, (44.565% identity in 92 aa overlap); and Q8XFW6 transposase from Brucella melitensis (93 aa), fasta scores: opt: 207, E(): 3.7e-06, (38.043% identity in 92 aa overlap); Q98A50 Transposase from Rhizobium loti (Mesorhizobium loti) (98 aa), fasta scores: opt: 204, E(): 6e-06, (37.234% identity in 94 aa overlap); Q8UJV4 Transposase from Agrobacterium tumefaciens plasmid AT (strain C58 / ATCC 33970) (96 aa), fasta scores: opt: 199, E(): 1.2e-05, (37.634% identity in 93 aa overlap). Contains a Pfam match to entry PF01527 Transposase_8, Transposase. Contains a helix turn helix motif between aa 58->79, tandard_deviations: 5.30, Score 1795.000.; putative transposase 144693 2846543 MUP049c Mycobacterium ulcerans Agy99 putative transposase YP_025571.1 144304 R 362242 CDS YP_025572.1 49146134 2846544 144660..145994 1 NC_005916.1 MUP050, -, len: 444 aa. Probable transposase for IS2606, highly similar to Q9ZG97 Probable transposase from Mycobacterium ulcerans (444 aa), fasta scores: opt: 2878, E(): 2.7e-186, (98.423% identity in 444 aa overlap); and to O05912 Hypothetical 48.7 kDa protein (IS1554, transposase) from M. tuberculosis (439 aa), fasta scores: opt: 2053, E(): 1.2e-130, (70.805% identity in 435 aa overlap).; transposase for the insertion element IS2606 145994 2846544 MUP050 Mycobacterium ulcerans Agy99 transposase for the insertion element IS2606 YP_025572.1 144660 D 362242 CDS YP_025573.1 49146135 2846545 146252..146533 1 NC_005916.1 MUP051, -, len: 93 aa. Putative transposase, similar to several transposases from Rhizobium loti (Mesorhizobium loti) e.g. Q8KHM1 Putative insertion element transposase protein (88 aa), fasta scores: opt: 254, E(): 2.3e-10, (48.889% identity in 90 aa overlap). And weakly similar to several transposases from Yersinia e.g. O68709 Putative transposase from Yersinia pestis (88 aa), fasta scores: opt: 234, E(): 5.3e-09, (37.778% identity in 90 aa overlap). And some similarity to MUP044. Contains a Pfam match to entry PF01527, Transposase_8, Transposase. Contains helix turn helix motif between aa 27->48, Standard_deviations: 4.91, score 1680.00.; putative transposase 146533 2846545 MUP051 Mycobacterium ulcerans Agy99 putative transposase YP_025573.1 146252 D 362242 CDS YP_025574.1 49146136 2846546 146563..147396 1 NC_005916.1 MUP052, -, len: 277 aa. Putative transposase, weakly similar to several transposases e.g Q89TF0 Blr2054 protein from Bradyrhizobium japonicum (290 aa), fasta scores: E(): 1.9e-27, (38.224% identity in 259 aa overlap); Q8U751 IS3 family transposase from Agrobacterium tumefaciens (strain C58 / ATCC 33970) (309 aa), fasta scores: opt: 549, E(): 1.3e-29, (39.068% identity in 279 aa overlap); Q8KJC6 Putative transposase for insertion sequence from Rhizobium loti (Mesorhizobium loti) (309 aa), fasta scores: opt: 528, E(): 2.5e-25 (35.836% identity in 293 aa overlap). Contains a Pfam match to PF00665 rve, Integrase core domain and a PS50316 histidine-rich region.; putative transposase 147396 2846546 MUP052 Mycobacterium ulcerans Agy99 putative transposase YP_025574.1 146563 D 362242 CDS YP_025575.1 49146137 2846568 complement(147546..148859) 1 NC_005916.1 MUP053c, cyp150, len: 437 aa. Probable cyp150, cytochrome p450 (EC 1.14.-.-), similar to O08464|C140_MYCTU|Rv1880c Probable cytochrome P450 140 from M. tuberculosis (438 aa), fasta scores: opt: 1873, E(): 6.7e-117, (62.529% identity in 435 aa overlap). And weakly similar to numerous others e.g. Q89G11|BAC51802 Bll6537 protein from Bradyrhizobium japonicum (433 aa), fasta scores: opt: 755, E(): 6.1e-41 (34.925% identity in 398 aa overlap); and Q9X8Q3 Putative cytochrome P450 from Streptomyces coelicolor (411 aa), fasta scores: E(): 2.9e-36, (34.063% identity in 411 aa overlap). Contains a Pfam match to entry PF00067, Cytochrome P450. Belongs to the cytochrome P450 family.; cytochrome p450 150 cyp150 148859 cyp150 2846568 cyp150 Mycobacterium ulcerans Agy99 cytochrome p450 150 cyp150 YP_025575.1 147546 R 362242 CDS YP_025576.1 49146138 2846547 complement(148856..149359) 1 NC_005916.1 MUP054c, -, len: 167 aa. Possible integrase fragment, weakly similar to several e.g. AAO22922 Integrase/recombinase from Myxococcus xanthus (300 aa), fasta scores: opt: 176, E(): 0.00018, (37.4% identity in 107 aa overlap); Q8NNZ9 Integrase from Corynebacterium glutamicum (Brevibacterium flavum) (308 aa), fasta scores: opt: 169, E(): 0.00054, (33.33% identity in 84 aa overlap); and Q8L3A3 Putative integrase/recombinase Xer from Bacillus stearothermophilus (304 aa), fasta scores: opt: 168, E(): 0.00063, (33.02% identity in 106 aa overlap). Contains a Pfam match to entry PF00589 Phage_integrase Phage integrase family.; integrase fragment 149359 2846547 MUP054c Mycobacterium ulcerans Agy99 integrase fragment YP_025576.1 148856 R 362242 CDS YP_025577.1 49146139 2846577 149323..150657 1 NC_005916.1 MUP055, -, len: 444 aa. Probable transposase for IS2606, highly similar to Q9ZG97 Probable transposase from Mycobacterium ulcerans (444 aa), fasta scores: opt: 2879, E(): 1.7e-184, (98.198% identity in 444 aa overlap); and to O05912 Hypothetical 48.7 kDa protein (IS1554, transposase) from M. tuberculosis (439 aa), fasta scores: opt: 2055, E(): 1.9e-129, (70.575% identity in 435 aa overlap).; transposase for the insertion element IS2606 150657 2846577 MUP055 Mycobacterium ulcerans Agy99 transposase for the insertion element IS2606 YP_025577.1 149323 D 362242 CDS YP_025578.1 49146140 2846578 complement(150862..151242) 1 NC_005916.1 MUP056c, -, len: 126 aa. Hypothetical protein.; hypothetical protein 151242 2846578 MUP056c Mycobacterium ulcerans Agy99 hypothetical protein YP_025578.1 150862 R 362242 CDS YP_025579.1 49146141 2846579 complement(151341..152117) 1 NC_005916.1 MUP057c, -, len: 258 aa. Possible lipoprotein, weakly similar to Q49597 MK35 lipoprotein precursor from Mycobacterium kansasii (225 aa), fasta scores: opt: 139, E(): 0.21, (27.059% identity in 170 aa overlap); and weakly similar at the N-terminus to Q8XCD1 Hypothetical protein z2967 from Escherichia coli O157:H7 (115 aa), fasta scores: opt: 148, E(): 0.037, (29.167% identity in 96 aa overlap). Has signal peptide and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site.; lipoprotein 152117 2846579 MUP057c Mycobacterium ulcerans Agy99 lipoprotein YP_025579.1 151341 R 362242 CDS YP_025580.1 49146142 2846580 complement(152314..153351) 1 NC_005916.1 MUP058c, -, len: 345 aa. Possible site-specific recombinase, weakly similar to several e.g. Q8U9U6 Site-specific recombinase from Agrobacterium tumefaciens (strain C58 / ATCC 33970) (331 aa), fasta scores: opt: 278, E(): 1.6e-11, (26.441% identity in 295 aa overlap)Q9JW14 Putative integrase/recombinase from Neisseria meningitidis (serogroup A) (305 aa), fasta scores: opt: 271, E(): 4.6e-11, (28.808% identity in 302 aa overlap); and O31206 Site-specific recombinase from Proteus mirabilis (313 aa), fasta scores: opt: 258, E(): 3.7e-10 (31.010% identity in 287 aa overlap). Contains Pfam match entries to PF02899 Phage integrase and PF00589 Phage integrase family.; site-specific recombinase 153351 2846580 MUP058c Mycobacterium ulcerans Agy99 site-specific recombinase YP_025580.1 152314 R 362242 CDS YP_025581.1 49146143 2846586 complement(153595..154641) 1 NC_005916.1 MUP059c, -, len: 348 aa. Probable transposase for IS2404, highly similar to O07439 Putative transposase from Mycobacterium ulcerans (327 aa), fasta scores: opt: 1839, E(): 2.4e-119, (92.949% identity in 312 aa overlap).; transposase for the insertion element IS2404 154641 2846586 MUP059c Mycobacterium ulcerans Agy99 transposase for the insertion element IS2404 YP_025581.1 153595 R 362242 CDS YP_025582.1 49146144 2846587 155147..155668 1 NC_005916.1 MUP060, -, len: 173 aa. Probable IS2606 transposase fragment, highly similar to the N-terminus of Q9ZG97 Probable transposase from Mycobacterium ulcerans (444 aa), fasta scores: opt: 886, E(): 1.8e-52, (84.615% identity in 169 aa overlap); and to the N-terminus of O05912 Hypothetical 48.7 kDa protein (IS1554, transposase) from M. tuberculosis (439 aa), fasta scores: opt: 506, E(): 1.1e-26, (60.000% identity in 135 aa overlap). The transposase described here may be made by a frame shifting mechanism during translation that fuses MUP060 and MUP061, no sequence errors have been identified to account for this.; transposase for the insertion element IS2606 (fragment) 155668 2846587 MUP060 Mycobacterium ulcerans Agy99 transposase for the insertion element IS2606 (fragment) YP_025582.1 155147 D 362242 CDS YP_025583.1 49146145 2846588 155574..156482 1 NC_005916.1 MUP061, -, len: 302 aa. Probable IS2606 transposase fragment, highly similar to the C-terminus of Q9ZG97 Probable transposase from Mycobacterium ulcerans (444 aa), fasta scores: opt: 1990, E(): 2.8e-132, (98.675% identity in 302 aa overlap); and to the C-terminus of O05912 Hypothetical 48.7 kDa protein (IS1554, transposase) from M. tuberculosis (439 aa), fasta scores: opt: 1544, E(): 6.9e-101, (75.166% identity in 302 aa overlap). The transposase described here may be made by a frame shifting mechanism during translation that fuses MUP060 and MUP061, no sequence errors have been identified to account for this.; transposase for the insertion element IS2606 (fragment) 156482 2846588 MUP061 Mycobacterium ulcerans Agy99 transposase for the insertion element IS2606 (fragment) YP_025583.1 155574 D 362242 CDS YP_025584.1 49146146 2846589 156842..157546 1 NC_005916.1 MUP062, -, len: 234 aa. Probable IS2404 transposase fragment, highly similar to O07439 Putative transposase from M. ulcerans (327 aa), fasta scores: opt: 1333, E(): 2.7e-84, (91.880% identity in 234 aa overlap). Note that this homology extends across the stop codon and directly into MUP063, suggesting a possible readthrough of the TAG stop codon. No sequence errors have been identified and this insertion sequence containing the internal stop codon is repeated at two other locations on the plasmid, MUP029 + MUP030 and MUP047 + MUP048.; transposase for the insertion element IS2404 (fragment) 157546 2846589 MUP062 Mycobacterium ulcerans Agy99 transposase for the insertion element IS2404 (fragment) YP_025584.1 156842 D 362242 CDS YP_025585.1 49146147 2846590 157547..157888 1 NC_005916.1 MUP063, -, len: 113 aa. Probable IS2404 transposase fragment, highly similar to the C-terminus of O07439 Putative transposase from M. ulcerans (327 aa), fasta scores: opt: 503, E(): 1.9e-31, (96.104% identity in 77 aa overlap). Note that this homology extends across the upstream TAG stop codon into the upstream MUP062, suggesting a possible readthrough of the previous stop codon. No sequence errors have been identified and this insertion sequence containing the internal stop codon is repeated at two other locations on the plasmid, MUP029 + MUP030 and MUP047 + MUP048.; transposase for the insertion element IS2404 (fragment) 157888 2846590 MUP063 Mycobacterium ulcerans Agy99 transposase for the insertion element IS2404 (fragment) YP_025585.1 157547 D 362242 CDS YP_025586.1 49146148 2846601 complement(157889..158251) 1 NC_005916.1 MUP064c, -, len: 120 aa. Possible conserved membrane protein, shows some similarity with other putative membrane proteins e.g. C-terminus of O06345|Rv3482c Probable conserved membrane protein from M. tuberculosis (260 aa), fasta scores: opt: 129, E(): 0.39, (30.233% identity in 86 aa overlap). And show some similarity to Mycobacteriophage proteins e.g. AAN12600 Gp39 from Mycobacteriophage (132 aa), fasta score: E(): 0.055, (40.000% identity in 50 aa overlap). Contains several membrane spanning regions towards the C-terminus.; hypothetical protein 158251 2846601 MUP064c Mycobacterium ulcerans Agy99 hypothetical protein YP_025586.1 157889 R 362242 CDS YP_025587.1 49146149 2846602 complement(158471..159352) 1 NC_005916.1 MUP065c, -, len: 293 aa. Conserved hypothetical protein, weakly similar at the N-terminus to several hypothetical proteins e.g. Q8U687 Hypothetical protein Atu6048 from Agrobacterium tumefaciens (strain C58 / ATCC 33970) (836 aa), fasta scores: opt: 223, E(): 8.2e-07, (30.000% identity in 170 aa overlap); and also some similarity at the N-terminus to several helicases e.g. AAO50170 Putative helicase from Streptomyces violaceoruber (866 aa), fasta scores: E(): 1.1e-09, (33.032% identity in 221 aa overlap); and P44701|SRMB_HAEIN ATP-dependent RNA helicase srmB homolog from Haemophilus influenzae (439 aa), fasta scores: opt: 124, E(): 1.9, (31.429% identity in 105 aa overlap). Contains a Pfam match to entry PF00270, DEAD/DEAD box helicase.; hypothetical protein 159352 2846602 MUP065c Mycobacterium ulcerans Agy99 hypothetical protein YP_025587.1 158471 R 362242 CDS YP_025588.1 49146150 2846603 complement(159824..160330) 1 NC_005916.1 MUP066c, -, len: 168 aa. Conserved hypothetical protein, weakly similar to several bacteriophage-related proteins e.g. P03796|Y77_BPT7 Hypothetical gene 7.7 protein from Bacteriophage T7 (130 aa), fasta scores: opt: 171, E(): 0.0002, (32.075% identity in 106 aa overlap); and Q8XUF2 Putative bacteriophage-related protein from Ralstonia solanacearum (Pseudomonas solanacearum) (183 aa), fasta scores: opt: 163, E(): 0.00089, (32.773% identity in 119 aa overlap). Contains a Prosite match to entry PS00029 LEUCINE_ZIPPER Leucine zipper pattern.; hypothetical protein 160330 2846603 MUP066c Mycobacterium ulcerans Agy99 hypothetical protein YP_025588.1 159824 R 362242 CDS YP_025589.1 49146151 2846604 complement(160417..161049) 1 NC_005916.1 MUP067c, -, len: 210 aa. Conserved hypothetical protein, weak similarity to N-terminus of spermidine synthases e.g. Q82EU4 Putative spermidine synthase from Streptomyces avermitilis (548 aa), FASTA scores: opt: 124, E(): 2.5, (34.091% identity in 88 aa overlap); and weak similarity to N-terminus of O87639|SCO3941 Putative serine/threonine phosphatase from Streptomyces coelicolor (368 aa), fasta scores: opt: 112, E(): 12, (27.919% identity in 197 aa overlap).; hypothetical protein 161049 2846604 MUP067c Mycobacterium ulcerans Agy99 hypothetical protein YP_025589.1 160417 R 362242 CDS YP_025590.1 49146152 2846605 complement(161085..162215) 1 NC_005916.1 MUP068c, -, len: 376 aa. Conserved membrane protein, similar to several Mycobacterial membrane proteins e.g. O53933|Rv1782 (506 aa) from M. tuberculosis, fasta scores: opt: 763, E(): 1.8e-34, (41.935% identity in 341 aa overlap); Q9Z5I3 Hypothetical 53.9 kDa protein (Conserved membrane protein) from M. leprae (506 aa), fasta scores: opt: 733, E(): 4.2e-32, (38.596% identity in 399 aa overlap); and the M. tuberculosis proteins Rv3895c, Rv0283, Rv3869 and Rv3450c. And also weakly similar to other bacterial hypothetical proteins e.g. Q8NSU6 Hypothetical protein Cgl0571 from Corynebacterium glutamicum (419 aa), fasta scores: opt: 349, E(): 4.3e-12, (31.818% identity in 242 aa overlap). Contains a Pfam match to entry PF05108 DUF690, protein of unknown function and a Prosite match to entry PS50310 alanine-rich region. Contains a possible N-terminal signal sequence.; hypothetical protein 162215 2846605 MUP068c Mycobacterium ulcerans Agy99 hypothetical protein YP_025590.1 161085 R 362242 CDS YP_025591.1 49146153 2846581 complement(162445..163779) 1 NC_005916.1 MUP069c, -, len: 444 aa. Probable transposase for IS2606, highly similar to Q9ZG97 Probable transposase from Mycobacterium ulcerans (444 aa), fasta scores: opt: 2867, E(): 8e-184, (97.973% identity in 444 aa overlap); and to O05912 Hypothetical 48.7 kDa protein (IS1554, transposase) from M. tuberculosis (439 aa), fasta scores: opt: 2043, E(): 9.7e-129, (70.345% identity in 435 aa overlap).; transposase for the insertion element IS2606 163779 2846581 MUP069c Mycobacterium ulcerans Agy99 transposase for the insertion element IS2606 YP_025591.1 162445 R 362242 CDS YP_025592.1 49146154 2846582 complement(163727..164824) 1 NC_005916.1 MUP070c, -, len: 365 aa. Conserved hypothetical protein, weakly similar to part of Q9KYC4 Hypothetical protein SCO6906 from Streptomyces coelicolor (529 aa), fasta scores: opt: 185, E(): 0.0015, (27.305% identity in 282 aa overlap). Similarity to Q9KYC4 begins in the upstream CDS, and this could be accounted for by a frameshift, although the sequence has been checked and no discrepancy was found.; hypothetical protein 164824 2846582 MUP070c Mycobacterium ulcerans Agy99 hypothetical protein YP_025592.1 163727 R 362242 CDS YP_025593.1 49146155 2846583 complement(164673..165089) 1 NC_005916.1 MUP071c, -, len: 138 aa. Conserved hypothetical protein, weakly similar to the N-terminus of Q9KYC4 Hypothetical protein SCO6906 from Streptomyces coelicolor (529 aa), fasta scores: opt: 153, E(): 0.0041, (29.060% identity in 117 aa overlap). Similarity to Q9KYC4 continues in the following CDS, and this could be accounted for by a frameshift, although the sequence has been checked and no discrepancy was found.; hypothetical protein 165089 2846583 MUP071c Mycobacterium ulcerans Agy99 hypothetical protein YP_025593.1 164673 R 362242 CDS YP_025594.1 49146156 2846584 complement(165161..166357) 1 NC_005916.1 MUP072c, -, len: 398 aa. Conserved hypothetical protein, some similarity to proteins from Caenorhabditis elegans e.g. Q20739 F54B11.2 protein (304 aa), fasta scores: opt: 192, E(): 0.017, (39.216% identity in 102 aa overlap); and CAE11316 C. elegans COL-185 protein (305 aa), fasta scores: opt: 185, E(): 0.039, (38.235% identity in 102 aa overlap). Contains a Prosite match to entry PS50310 ALA_RICH Alanine-rich region.; hypothetical protein 166357 2846584 MUP072c Mycobacterium ulcerans Agy99 hypothetical protein YP_025594.1 165161 R 362242 CDS YP_025595.1 49146157 2846585 complement(166354..167547) 1 NC_005916.1 MUP073c, -, len: 397 aa. Conserved hypothetical protein. Some similarity to part of Q9Z5I9|IF2_MYCLE|ML1556 Translation initiation factor IF-2 from M. leprae (924 aa), fasta scores: opt: 228, E(): 0.0023, (26.997% identity in 363 aa overlap). Contains a Prosite match to entry PS00015 NUCLEAR Bipartite nuclear targeting sequence.; hypothetical protein 167547 2846585 MUP073c Mycobacterium ulcerans Agy99 hypothetical protein YP_025595.1 166354 R 362242 CDS YP_025596.1 49146158 2846591 complement(167568..168152) 1 NC_005916.1 MUP074c, -, len: 194 aa. Possible membrane protein, weakly similar to several bacterial membrane and hypothetical proteins e.g. O53200|Rv2473 Hypothetical protein from M. tuberculosis (238 aa), fasta scores: opt: 155, E(): 0.18, (25.248% identity in 202 aa overlap); O86726 Hypothetical protein SCO6544 from Streptomyces coelicolor (226 aa), fasta scores: opt: 155, E(): 0.18, (25.405% identity in 185 aa overlap). Contains a Prosite match to entry PS50310 ALA_RICH Alanine-rich region. Contains hydrophobic region in the N-terminus.; hypothetical protein 168152 2846591 MUP074c Mycobacterium ulcerans Agy99 hypothetical protein YP_025596.1 167568 R 362242 CDS YP_025597.1 49146159 2846592 complement(168149..168487) 1 NC_005916.1 MUP075c, -, len: 112 aa. Hypothetical protein, some similarity to part of Q8Y3B8 Probable substrate-binding transmembrane protein from Ralstonia solanacearum (Pseudomonas solanacearum) (801 aa), fasta scores: opt: 131, E(): 1.1, (33.33% identity in 102 aa overlap). Contains a Prosite match to entry PS50310 ALA_RICH Alanine-rich region.; hypothetical protein 168487 2846592 MUP075c Mycobacterium ulcerans Agy99 hypothetical protein YP_025597.1 168149 R 362242 CDS YP_025598.1 49146160 2846593 complement(168487..169158) 1 NC_005916.1 MUP076c, -, len: 223 aa. Possible membrane protein, contains a membrane spanning region between aa 57 to 79. Contains a Prosite match to entry PS50099 PRO_RICH Proline-rich region.; hypothetical protein 169158 2846593 MUP076c Mycobacterium ulcerans Agy99 hypothetical protein YP_025598.1 168487 R 362242 CDS YP_025599.1 49146161 2846594 complement(169192..169584) 1 NC_005916.1 MUP077c, -, len: 130 aa. Conserved hypothetical protein, weakly similar to P71600|Y030_MYCTU|Rv0030 Hypothetical protein from M. tuberculosis (109 aa), fasta scores: opt: 122, E(): 0.42, (27.660% identity in 94 aa overlap); and O69744|Rv3880c Hypothetical protein from M. tuberculosis (115 aa), fasta scores: opt: 112, E(): 2.1, (29.000% identity in 100 aa overlap).; hypothetical protein 169584 2846594 MUP077c Mycobacterium ulcerans Agy99 hypothetical protein YP_025599.1 169192 R 362242 CDS YP_025600.1 49146162 2846595 complement(169759..171342) 1 NC_005916.1 MUP078c, -, len: 527 aa. Conserved hypothetical protein, weakly similar to Q10691|YK83_MYCTU|Rv2083 Hypothetical protein from M. tuberculosis (314 aa), fasta scores: opt: 229, E(): 0.0041, (32.597% identity in 181 aa overlap); Q8WTL8 Hypothetical 37.7 kDa protein from Caenorhabditis elegans (435 aa), fasta scores: opt: 233, E(): 0.0034, (32.093% identity in 215 aa overlap); and also weakly similar to several PGRS-family proteins e.g. O53884|Rv0872c|PE_PGRS15 PGRS-family protein from M. tuberculosis (606 aa), fasta scores: opt: 220, E(): 0.016, (25.686% identity in 510 aa overlap). Contains a Prosite match to entry PS00029 LEUCINE_ZIPPER Leucine zipper pattern.; hypothetical protein 171342 2846595 MUP078c Mycobacterium ulcerans Agy99 hypothetical protein YP_025600.1 169759 R 362242 CDS YP_025601.1 49146163 2846565 complement(171361..171660) 1 NC_005916.1 MUP079c, -, len: 99 aa. Conserved hypothetical protein, weakly similar to P71598|Y028_MYCTU|Rv0028 Hypothetical protein from M. tuberculosis (101 aa), fasta scores: opt: 93, E(): 11, (32.558% identity in 86 aa overlap); and some similarity to Q51652 DNA primase (Fragment) from Escherichia coli (489 aa), fasta scores: opt: 101, E(): 11, (29.762% identity in 84 aa overlap).; hypothetical protein 171660 2846565 MUP079c Mycobacterium ulcerans Agy99 hypothetical protein YP_025601.1 171361 R 362242 CDS YP_025602.1 49146164 2846566 complement(171667..171939) 1 NC_005916.1 MUP080c, -, len: 90 aa. Conserved hypothetical protein, weakly similar to P71597|Y027_MYCTU|Rv0027 Hypothetical protein from M. tuberculosis (105 aa), fasta scores: opt: 117, E(): 0.3, (26.966% identity in 89 aa overlap).; hypothetical protein 171939 2846566 MUP080c Mycobacterium ulcerans Agy99 hypothetical protein YP_025602.1 171667 R 362242 CDS YP_025603.1 49146165 2846567 complement(172002..173546) 1 NC_005916.1 MUP081c, -, len: 514 aa. Conserved hypothetical protein, weakly similar to P71596|YO26_MYCTU|Rv0026 Hypothetical protein from M. tuberculosis (448 aa), fasta scores: opt: 501 E(): 6.9e-15, (31.989% identity in 372 aa overlap). Contains a Prosite match to entry PS00017 ATP_GTP_A- ATP/GTP-binding site motif A (P-loop).; hypothetical protein 173546 2846567 MUP081c Mycobacterium ulcerans Agy99 hypothetical protein YP_025603.1 172002 R 362242 CDS YP_904252.1 118615920 4553245 1..1533 1 NC_008611.1 binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself.; chromosomal replication initiation protein 1533 dnaA 4553245 dnaA Mycobacterium ulcerans Agy99 chromosomal replication initiation protein YP_904252.1 1 D 362242 CDS YP_904253.1 118615921 4553246 2072..3280 1 NC_008611.1 binds the polymerase to DNA and acts as a sliding clamp; DNA polymerase III subunit beta 3280 dnaN 4553246 dnaN Mycobacterium ulcerans Agy99 DNA polymerase III subunit beta YP_904253.1 2072 D 362242 CDS YP_904254.1 118615922 4553247 3301..4458 1 NC_008611.1 Required for DNA replication; binds preferentially to single-stranded, linear DNA; recombination protein F 4458 recF 4553247 recF Mycobacterium ulcerans Agy99 recombination protein F YP_904254.1 3301 D 362242 CDS YP_904255.1 118615923 4553248 4455..5018 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; hypothetical protein 5018 4553248 MUL_0004 Mycobacterium ulcerans Agy99 hypothetical protein YP_904255.1 4455 D 362242 CDS YP_904256.1 118615924 4553249 5228..7306 1 NC_008611.1 negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit B 7306 gyrB 4553249 gyrB Mycobacterium ulcerans Agy99 DNA gyrase subunit B YP_904256.1 5228 D 362242 CDS YP_904257.1 118615925 4553250 7346..9865 1 NC_008611.1 negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit A 9865 gyrA 4553250 gyrA Mycobacterium ulcerans Agy99 DNA gyrase subunit A YP_904257.1 7346 D 362242 CDS YP_904258.1 118615926 4553251 9949..10947 1 NC_008611.1 membrane protein; hypothetical protein 10947 4553251 MUL_0007 Mycobacterium ulcerans Agy99 hypothetical protein YP_904258.1 9949 D 362242 CDS YP_904259.1 118615927 4553254 11361..12197 1 NC_008611.1 cytoplasmic protein; hypothetical protein 12197 4553254 MUL_0010 Mycobacterium ulcerans Agy99 hypothetical protein YP_904259.1 11361 D 362242 CDS YP_904260.1 118615928 4553255 complement(12225..12986) 1 NC_008611.1 cytoplasmic protein; transcription; transcriptional regulator 12986 4553255 MUL_0011 Mycobacterium ulcerans Agy99 transcriptional regulator YP_904260.1 12225 R 362242 CDS YP_904261.1 118615929 4553256 complement(13097..13501) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 13501 4553256 MUL_0012 Mycobacterium ulcerans Agy99 hypothetical protein YP_904261.1 13097 R 362242 CDS YP_904262.1 118615930 4553257 13691..14239 1 NC_008611.1 Also detected in the extracellular matrix by proteomics.; cytoplasmic protein; Ppiases accelerate the folding of proteins [catalytic activity: cis-trans isomerization of proline imidic peptide bonds in oligopeptides]; peptidyl-prolyl cis-trans isomerase A, PpiA 14239 ppiA 4553257 ppiA Mycobacterium ulcerans Agy99 peptidyl-prolyl cis-trans isomerase A, PpiA YP_904262.1 13691 D 362242 CDS YP_904263.1 118615931 4553258 complement(14250..14675) 1 NC_008611.1 membrane protein; hypothetical protein 14675 4553258 MUL_0014 Mycobacterium ulcerans Agy99 hypothetical protein YP_904263.1 14250 R 362242 CDS YP_904264.1 118615932 4552742 complement(14831..15112) 1 NC_008611.1 integral membrane protein involved in inhibition of the Z-ring formation; putative septation inhibitor protein 15112 4552742 MUL_0015 Mycobacterium ulcerans Agy99 putative septation inhibitor protein YP_904264.1 14831 R 362242 CDS YP_904265.1 118615933 4552743 15241..15984 1 NC_008611.1 membrane protein; hypothetical protein 15984 4552743 MUL_0016 Mycobacterium ulcerans Agy99 hypothetical protein YP_904265.1 15241 D 362242 CDS YP_904266.1 118615934 4552744 16022..16708 1 NC_008611.1 aminodeoxychorismate synthase subunit PabA; with PabB catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine in para-aminobenzoate synthesis; PabA provides the glutamine amidotransferase activity; para-aminobenzoate synthase component II 16708 trpG 4552744 trpG Mycobacterium ulcerans Agy99 para-aminobenzoate synthase component II YP_904266.1 16022 D 362242 CDS YP_904267.1 118615935 4552745 complement(16686..18566) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; involved in signal transduction (via phosphorylation) thought to regulate cell division/differentiation. can phosphorylate the peptide substrate myelin basic protein (MBP) [catalytic activity: ATP + a protein = ADP + a phosphoprotein]; serine/threonine-protein kinase B PknB 18566 pknB 4552745 pknB Mycobacterium ulcerans Agy99 serine/threonine-protein kinase B PknB YP_904267.1 16686 R 362242 CDS YP_904268.1 118615936 4552746 complement(18563..19921) 1 NC_008611.1 membrane protein; involved in signal transduction (via phosphorylation) thought to regulate morphological changes associated with cell division/differentiation process. phosphorylates at serine and threonine residues [catalytic activity: ATP + a protein = ADP + a phosphoprotein]; serine/threonine-protein kinase a PknA 19921 pknA 4552746 pknA Mycobacterium ulcerans Agy99 serine/threonine-protein kinase a PknA YP_904268.1 18563 R 362242 CDS YP_904269.1 118615937 4552747 complement(19918..21393) 1 NC_008611.1 membrane protein; involved in peptidoglycan synthesis (at the final stages) cell wall formation; PbpA is supposed to be responsible for the determination of the rod shape of the cell. its synthesizes cross-linked peptidoglycan from lipid intermediates.; penicillin-binding protein PbpA 21393 pbpA 4552747 pbpA Mycobacterium ulcerans Agy99 penicillin-binding protein PbpA YP_904269.1 19918 R 362242 CDS YP_904270.1 118615938 4552748 complement(21390..22799) 1 NC_008611.1 membrane protein; this is a septum-peptidoglycan biosynthetic protein, involved in cell wall formation. plays a role in the stabilization of the FtsZ ring during cell division.; cell division protein RodA 22799 rodA 4552748 rodA Mycobacterium ulcerans Agy99 cell division protein RodA YP_904270.1 21390 R 362242 CDS YP_904271.1 118615939 4552749 complement(22796..24355) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS) Also detected in the cytoplasmic fraction by 2D-LC- MS/MS.; membrane protein; involved in regulation (using dephosphorylation of a specific phosphorylated substrate); serine/threonine phosphatase PstP 24355 pstP 4552749 pstP Mycobacterium ulcerans Agy99 serine/threonine phosphatase PstP YP_904271.1 22796 R 362242 CDS YP_904272.1 118615940 4552750 complement(24352..24819) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; hypothetical protein 24819 4552750 MUL_0023 Mycobacterium ulcerans Agy99 hypothetical protein YP_904272.1 24352 R 362242 CDS YP_904273.1 118615941 4552751 complement(24953..26551) 1 NC_008611.1 Detected in the cytoplasmic and secreted fractions by 2D-LC-MS/MS.; secreted protein; function unknown, contains FHA domain; hypothetical protein 26551 4552751 MUL_0024 Mycobacterium ulcerans Agy99 hypothetical protein YP_904273.1 24953 R 362242 CDS YP_904274.1 118615942 4552752 26845..28179 1 NC_008611.1 cytoplasmic protein; required for the transposition of the insertion element IS2606.; transposase for IS2606 28179 4552752 MUL_0025 Mycobacterium ulcerans Agy99 transposase for IS2606 YP_904274.1 26845 D 362242 CDS YP_904275.1 118615943 4552754 28617..29372 1 NC_008611.1 cytoplasmic protein; glycosylase 29372 4552754 MUL_0027 Mycobacterium ulcerans Agy99 glycosylase YP_904275.1 28617 D 362242 CDS YP_904276.1 118615944 4552755 complement(29488..30162) 1 NC_008611.1 cytoplasmic protein; shortchain dehydrogenase 30162 4552755 MUL_0028 Mycobacterium ulcerans Agy99 shortchain dehydrogenase YP_904276.1 29488 R 362242 CDS YP_904277.1 118615945 4552756 30440..31192 1 NC_008611.1 cytoplasmic protein; hypothetical protein 31192 4552756 MUL_0029 Mycobacterium ulcerans Agy99 hypothetical protein YP_904277.1 30440 D 362242 CDS YP_904278.1 118615946 4552164 complement(32216..32920) 1 NC_008611.1 membrane protein; hypothetical protein 32920 4552164 MUL_0032 Mycobacterium ulcerans Agy99 hypothetical protein YP_904278.1 32216 R 362242 CDS YP_904279.1 118615947 4552165 complement(33021..34220) 1 NC_008611.1 membrane protein; thought to be involved in active transport of osmoprotectant (glycine betaine/carnitine/choline/L- proline) across the membrane (import) responsible for energy coupling to the transport system.; osmoprotectant (glycine betaine/carnitine/choline/L-proline) transport ATP-binding protein ABC transporter ProV_1 34220 proV_1 4552165 proV_1 Mycobacterium ulcerans Agy99 osmoprotectant (glycine betaine/carnitine/choline/L-proline) transport ATP-binding protein ABC transporter ProV_1 YP_904279.1 33021 R 362242 CDS YP_904280.1 118615948 4552166 complement(34213..34860) 1 NC_008611.1 membrane protein; maybe involved in active transport of osmoprotectant (glycine betaine/carnitine/choline/L- proline) across the membrane (import) responsible for the translocation of the substrate across the membrane.; ABC transporter permease 34860 4552166 MUL_0034 Mycobacterium ulcerans Agy99 ABC transporter permease YP_904280.1 34213 R 362242 CDS YP_904281.1 118615949 4552167 35179..35586 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; DNA-binding protein 35586 4552167 MUL_0035 Mycobacterium ulcerans Agy99 DNA-binding protein YP_904281.1 35179 D 362242 CDS YP_904282.1 118615950 4552168 complement(35688..36635) 1 NC_008611.1 hypothetical protein 36635 4552168 MUL_0036 Mycobacterium ulcerans Agy99 hypothetical protein YP_904282.1 35688 R 362242 CDS YP_904283.1 118615951 4552169 36765..38078 1 NC_008611.1 membrane protein; thought to be involved in transport of ammonium across the membrane (export) responsible for the translocation of the substrate across the membrane.; ammonium-transport integral membrane protein, Amt_1 38078 amt_1 4552169 amt_1 Mycobacterium ulcerans Agy99 ammonium-transport integral membrane protein, Amt_1 YP_904283.1 36765 D 362242 CDS YP_904284.1 118615952 4552170 complement(38088..38387) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 38387 4552170 MUL_0038 Mycobacterium ulcerans Agy99 hypothetical protein YP_904284.1 38088 R 362242 CDS YP_904285.1 118615953 4552171 complement(38384..39301) 1 NC_008611.1 N-term truncated by frame-shift mutation; cytoplasmic protein; hypothetical protein 39301 4552171 MUL_0039 Mycobacterium ulcerans Agy99 hypothetical protein YP_904285.1 38384 R 362242 CDS YP_904286.1 118615954 4552172 complement(39468..39884) 1 NC_008611.1 cytoplasmic protein; involved in transcriptional mechanism.; transcriptional regulatory protein (Whib-like), WhiB5 39884 whiB5 4552172 whiB5 Mycobacterium ulcerans Agy99 transcriptional regulatory protein (Whib-like), WhiB5 YP_904286.1 39468 R 362242 CDS YP_904287.1 118615955 4552173 40027..40818 1 NC_008611.1 cytoplasmic protein; maybe involved in transcriptional mechanism.; transcriptional regulatory protein 40818 4552173 MUL_0041 Mycobacterium ulcerans Agy99 transcriptional regulatory protein YP_904287.1 40027 D 362242 CDS YP_904288.1 118615956 4552174 40815..41642 1 NC_008611.1 secreted protein; function unknown. the P60 protein is a major extracellular protein may be involved in the invasion of host cells.; secreted protein P60-related protein 41642 4552174 MUL_0042 Mycobacterium ulcerans Agy99 secreted protein P60-related protein YP_904288.1 40815 D 362242 CDS YP_904289.1 118615957 4552175 41639..42019 1 NC_008611.1 cytoplasmic protein; hypothetical protein 42019 4552175 MUL_0043 Mycobacterium ulcerans Agy99 hypothetical protein YP_904289.1 41639 D 362242 CDS YP_904290.1 118615958 4552176 42094..43359 1 NC_008611.1 cytoplasmic protein; hypothetical protein 43359 4552176 MUL_0044 Mycobacterium ulcerans Agy99 hypothetical protein YP_904290.1 42094 D 362242 CDS YP_904291.1 118615959 4552177 43402..43719 1 NC_008611.1 cytoplasmic protein; hypothetical protein 43719 4552177 MUL_0045 Mycobacterium ulcerans Agy99 hypothetical protein YP_904291.1 43402 D 362242 CDS YP_904292.1 118615960 4552178 43716..44120 1 NC_008611.1 cytoplasmic protein; hypothetical protein 44120 4552178 MUL_0046 Mycobacterium ulcerans Agy99 hypothetical protein YP_904292.1 43716 D 362242 CDS YP_904293.1 118615961 4552179 44248..45354 1 NC_008611.1 hypothetical protein 45354 4552179 MUL_0047 Mycobacterium ulcerans Agy99 hypothetical protein YP_904293.1 44248 D 362242 CDS YP_904294.1 118615962 4552180 45442..45762 1 NC_008611.1 cytoplasmic protein; hypothetical protein 45762 4552180 MUL_0048 Mycobacterium ulcerans Agy99 hypothetical protein YP_904294.1 45442 D 362242 CDS YP_904295.1 118615963 4552181 45887..46069 1 NC_008611.1 secreted protein; hypothetical protein 46069 4552181 MUL_0049 Mycobacterium ulcerans Agy99 hypothetical protein YP_904295.1 45887 D 362242 CDS YP_904296.1 118615964 4552182 complement(46161..46934) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 46934 4552182 MUL_0050 Mycobacterium ulcerans Agy99 hypothetical protein YP_904296.1 46161 R 362242 CDS YP_904297.1 118615965 4552183 complement(46937..48229) 1 NC_008611.1 membrane protein; integral membrane protein 48229 4552183 MUL_0051 Mycobacterium ulcerans Agy99 integral membrane protein YP_904297.1 46937 R 362242 CDS YP_904298.1 118615966 4550136 48389..48994 1 NC_008611.1 cytoplasmic protein; hypothetical protein 48994 4550136 MUL_0052 Mycobacterium ulcerans Agy99 hypothetical protein YP_904298.1 48389 D 362242 CDS YP_904299.1 118615967 4550137 complement(48981..49976) 1 NC_008611.1 membrane protein; hypothetical protein 49976 4550137 MUL_0053 Mycobacterium ulcerans Agy99 hypothetical protein YP_904299.1 48981 R 362242 CDS YP_904300.1 118615968 4550138 complement(50029..50379) 1 NC_008611.1 membrane protein; hypothetical protein 50379 4550138 MUL_0054 Mycobacterium ulcerans Agy99 hypothetical protein YP_904300.1 50029 R 362242 CDS YP_904301.1 118615969 4550139 complement(50464..51597) 1 NC_008611.1 secreted protein; secreted proline rich protein Mtc28 51597 mtc28 4550139 mtc28 Mycobacterium ulcerans Agy99 secreted proline rich protein Mtc28 YP_904301.1 50464 R 362242 CDS YP_904302.1 118615970 4550140 51796..54726 1 NC_008611.1 leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase; leucyl-tRNA synthetase 54726 leuS 4550140 leuS Mycobacterium ulcerans Agy99 leucyl-tRNA synthetase YP_904302.1 51796 D 362242 CDS YP_904303.1 118615971 4550141 complement(54756..55421) 1 NC_008611.1 membrane protein; function unknown, possibly involved in cellular metabolism.; short chain dehydrogenase 55421 4550141 MUL_0057 Mycobacterium ulcerans Agy99 short chain dehydrogenase YP_904303.1 54756 R 362242 CDS YP_904304.1 118615972 4550142 complement(55462..55965) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); cytoplasmic protein; possibly involved in transcriptional mechanism.; transcriptional regulatory protein 55965 4550142 MUL_0058 Mycobacterium ulcerans Agy99 transcriptional regulatory protein YP_904304.1 55462 R 362242 CDS YP_904305.1 118615973 4550145 complement(58626..59390) 1 NC_008611.1 cytoplasmic protein; involved in transcriptional mechanism.; GntR family transcriptional regulator 59390 4550145 MUL_0061 Mycobacterium ulcerans Agy99 GntR family transcriptional regulator YP_904305.1 58626 R 362242 CDS YP_904306.1 118615974 4550146 complement(59501..60298) 1 NC_008611.1 cytoplasmic protein; function unknown, probably involved in cellular metabolism.; oxidoreductase 60298 4550146 MUL_0062 Mycobacterium ulcerans Agy99 oxidoreductase YP_904306.1 59501 R 362242 CDS YP_904307.1 118615975 4550147 complement(60330..61241) 1 NC_008611.1 cytoplasmic protein; function unknown, probably involved in lipid biosynthesis.; hydrolase 61241 4550147 MUL_0063 Mycobacterium ulcerans Agy99 hydrolase YP_904307.1 60330 R 362242 CDS YP_904308.1 118615976 4550148 complement(61287..62405) 1 NC_008611.1 involved in phosphatidylinositol (pi) biosynthetic pathway [catalytic activity: d-glucose 6-phosphate = 1L- myo-inositol 1-phosphate]; myo-inositol-1-phosphate synthase Ino1 62405 ino1 4550148 ino1 Mycobacterium ulcerans Agy99 myo-inositol-1-phosphate synthase Ino1 YP_904308.1 61287 R 362242 CDS YP_904309.1 118615977 4550149 complement(62467..63009) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 63009 4550149 MUL_0065 Mycobacterium ulcerans Agy99 hypothetical protein YP_904309.1 62467 R 362242 CDS YP_904310.1 118615978 4550150 complement(63165..64034) 1 NC_008611.1 membrane protein; hypothetical protein 64034 4550150 MUL_0066 Mycobacterium ulcerans Agy99 hypothetical protein YP_904310.1 63165 R 362242 CDS YP_904311.1 118615979 4550151 64147..64581 1 NC_008611.1 cytoplasmic protein; hypothetical protein 64581 4550151 MUL_0067 Mycobacterium ulcerans Agy99 hypothetical protein YP_904311.1 64147 D 362242 CDS YP_904312.1 118615980 4550152 65069..67111 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; involved in peptidoglycan synthesis (at the final stages), cell wall formation. synthesis of cross-linked peptidoglycan from the lipid intermediates. the enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits); bifunctional penicillin-binding protein 1A/1B PonA1 67111 ponA1 4550152 ponA1 Mycobacterium ulcerans Agy99 bifunctional penicillin-binding protein 1A/1B PonA1 YP_904312.1 65069 D 362242 CDS YP_904313.1 118615981 4550153 67108..68748 1 NC_008611.1 membrane protein; hypothetical protein 68748 4550153 MUL_0069 Mycobacterium ulcerans Agy99 hypothetical protein YP_904313.1 67108 D 362242 CDS YP_904314.1 118615982 4550154 68748..69386 1 NC_008611.1 cytoplasmic protein; transcriptional regulatory protein 69386 4550154 MUL_0070 Mycobacterium ulcerans Agy99 transcriptional regulatory protein YP_904314.1 68748 D 362242 CDS YP_904315.1 118615983 4551749 69510..69800 1 NC_008611.1 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21; 30S ribosomal protein S6 69800 rpsF 4551749 rpsF Mycobacterium ulcerans Agy99 30S ribosomal protein S6 YP_904315.1 69510 D 362242 CDS YP_904316.1 118615984 4551750 69892..70407 1 NC_008611.1 binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA; single-stranded DNA-binding protein 70407 ssb 4551750 ssb Mycobacterium ulcerans Agy99 single-stranded DNA-binding protein YP_904316.1 69892 D 362242 CDS YP_904317.1 118615985 4551751 70453..70707 1 NC_008611.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit; 30S ribosomal protein S18 70707 rpsR 4551751 rpsR Mycobacterium ulcerans Agy99 30S ribosomal protein S18 YP_904317.1 70453 D 362242 CDS YP_904318.1 118615986 4551752 70754..71212 1 NC_008611.1 in Escherichia coli this protein is wrapped around the base of the L1 stalk; 50S ribosomal protein L9 71212 rplI 4551752 rplI Mycobacterium ulcerans Agy99 50S ribosomal protein L9 YP_904318.1 70754 D 362242 CDS YP_904319.1 118615987 4551753 71743..73125 1 NC_008611.1 cytoplasmic protein; participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. the intein is an endonuclease (potential); replicative DNA helicase DnaB 73125 dnaB 4551753 dnaB Mycobacterium ulcerans Agy99 replicative DNA helicase DnaB YP_904319.1 71743 D 362242 CDS YP_904320.1 118615988 4551754 73690..74349 1 NC_008611.1 cytoplasmic protein; hypothetical protein 74349 4551754 MUL_0076 Mycobacterium ulcerans Agy99 hypothetical protein YP_904320.1 73690 D 362242 CDS YP_904321.1 118615989 4551755 complement(74478..75104) 1 NC_008611.1 cytoplasmic protein; function unknown, possibly involved in cellular metabolism.; hydrolase 75104 4551755 MUL_0077 Mycobacterium ulcerans Agy99 hydrolase YP_904321.1 74478 R 362242 CDS YP_904322.1 118615990 4551757 complement(77264..77878) 1 NC_008611.1 cytoplasmic protein; transcriptional regulator 77878 4551757 MUL_0080 Mycobacterium ulcerans Agy99 transcriptional regulator YP_904322.1 77264 R 362242 CDS YP_904323.1 118615991 4551758 77913..78218 1 NC_008611.1 cytoplasmic protein; hypothetical protein 78218 4551758 MUL_0081 Mycobacterium ulcerans Agy99 hypothetical protein YP_904323.1 77913 D 362242 CDS YP_904324.1 118615992 4551761 80415..80999 1 NC_008611.1 cytoplasmic protein; hypothetical protein 80999 4551761 MUL_0084 Mycobacterium ulcerans Agy99 hypothetical protein YP_904324.1 80415 D 362242 CDS YP_904325.1 118615993 4551763 82839..83144 1 NC_008611.1 cytoplasmic protein; involved in transcriptional mechanism.; transcriptional regulator 83144 4551763 MUL_0086 Mycobacterium ulcerans Agy99 transcriptional regulator YP_904325.1 82839 D 362242 CDS YP_904326.1 118615994 4551764 83141..83557 1 NC_008611.1 cytoplasmic protein; hypothetical protein 83557 4551764 MUL_0087 Mycobacterium ulcerans Agy99 hypothetical protein YP_904326.1 83141 D 362242 CDS YP_904327.1 118615995 4549582 85879..87126 1 NC_008611.1 cytoplasmic protein; hypothetical protein 87126 4549582 MUL_0089 Mycobacterium ulcerans Agy99 hypothetical protein YP_904327.1 85879 D 362242 CDS YP_904328.1 118615996 4549583 complement(87171..88127) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; may form an ATP-driven O-antigen/lipopolysaccharide export apparatus, in association with RfbE. responsible for the translocation of the substrate across the membrane.; O-antigen/lipopolysaccharide transport integral membrane protein ABC transporter RfbD 88127 rfbD 4549583 rfbD Mycobacterium ulcerans Agy99 O-antigen/lipopolysaccharide transport integral membrane protein ABC transporter RfbD YP_904328.1 87171 R 362242 CDS YP_904329.1 118615997 4549584 complement(87998..88972) 1 NC_008611.1 membrane protein; possibly involved in rhamnose biosynthesis; L-rhamnosyltransferase 88972 4549584 MUL_0091 Mycobacterium ulcerans Agy99 L-rhamnosyltransferase YP_904329.1 87998 R 362242 CDS YP_904330.1 118615998 4549585 complement(88920..89762) 1 NC_008611.1 membrane protein; may form an ATP-driven O-antigen/lipopolysaccharide export apparatus, in association with RfbD. responsible for energy coupling to the transport system.; O-antigen/lipopolysaccharide transport ATP- binding protein ABC transporter RfbE 89762 rfbE 4549585 rfbE Mycobacterium ulcerans Agy99 O-antigen/lipopolysaccharide transport ATP- binding protein ABC transporter RfbE YP_904330.1 88920 R 362242 CDS YP_904331.1 118615999 4549586 complement(89766..90299) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 90299 4549586 MUL_0093 Mycobacterium ulcerans Agy99 hypothetical protein YP_904331.1 89766 R 362242 CDS YP_904332.1 118616000 4549587 complement(90312..92285) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; transmembrane protein 92285 4549587 MUL_0094 Mycobacterium ulcerans Agy99 transmembrane protein YP_904332.1 90312 R 362242 CDS YP_904333.1 118616001 4549588 92416..93612 1 NC_008611.1 membrane protein; function unknown, probably involved in cellular metabolism.; aminotransferase 93612 4549588 MUL_0095 Mycobacterium ulcerans Agy99 aminotransferase YP_904333.1 92416 D 362242 CDS YP_904334.1 118616002 4549589 complement(93652..94644) 1 NC_008611.1 membrane protein; function unknown, probably involved in cellular metabolism.; oxidoreductase 94644 4549589 MUL_0096 Mycobacterium ulcerans Agy99 oxidoreductase YP_904334.1 93652 R 362242 CDS YP_904335.1 118616003 4549591 95273..96187 1 NC_008611.1 PPE62; membrane protein; PPE family protein 96187 4549591 MUL_0098 Mycobacterium ulcerans Agy99 PPE family protein YP_904335.1 95273 D 362242 CDS YP_904336.1 118616004 4549592 96405..97451 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 97451 4549592 MUL_0099 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_904336.1 96405 D 362242 CDS YP_904337.1 118616005 4551431 98998..100044 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 100044 4551431 MUL_0101 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_904337.1 98998 D 362242 CDS YP_904338.1 118616006 4551433 complement(101494..102528) 1 NC_008611.1 catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate; fructose-bisphosphate aldolase 102528 fba 4551433 fba Mycobacterium ulcerans Agy99 fructose-bisphosphate aldolase YP_904338.1 101494 R 362242 CDS YP_904339.1 118616007 4551434 102629..103321 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; transmembrane protein 103321 4551434 MUL_0104 Mycobacterium ulcerans Agy99 transmembrane protein YP_904339.1 102629 D 362242 CDS YP_904340.1 118616008 4551435 complement(103310..104449) 1 NC_008611.1 cytoplasmic protein; glycosyl hydrolase 104449 4551435 MUL_0105 Mycobacterium ulcerans Agy99 glycosyl hydrolase YP_904340.1 103310 R 362242 CDS YP_904341.1 118616009 4551439 109181..109954 1 NC_008611.1 catalyzes the formation of acetaldehyde from ethanolamine; ethanolamine ammonia-lyase small subunit 109954 eutC 4551439 eutC Mycobacterium ulcerans Agy99 ethanolamine ammonia-lyase small subunit YP_904341.1 109181 D 362242 CDS YP_904342.1 118616010 4551440 complement(109957..111162) 1 NC_008611.1 membrane protein; von Willebrand factor type A domain-containing protein 111162 4551440 MUL_0110 Mycobacterium ulcerans Agy99 von Willebrand factor type A domain-containing protein YP_904342.1 109957 R 362242 CDS YP_904343.1 118616011 4551441 complement(111169..111843) 1 NC_008611.1 Also detected in the cytoplasmic fraction by 2D-LC- MS/MS.; membrane protein; function unknown, probably involved in cellular metabolism.; membrane oxidoreductase 111843 4551441 MUL_0111 Mycobacterium ulcerans Agy99 membrane oxidoreductase YP_904343.1 111169 R 362242 CDS YP_904344.1 118616012 4551442 complement(111857..112735) 1 NC_008611.1 membrane protein; function unknown, probably involved in cellular metabolism.; membrane oxidoreductase 112735 4551442 MUL_0112 Mycobacterium ulcerans Agy99 membrane oxidoreductase YP_904344.1 111857 R 362242 CDS YP_904345.1 118616013 4551443 complement(112736..113326) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 113326 4551443 MUL_0113 Mycobacterium ulcerans Agy99 hypothetical protein YP_904345.1 112736 R 362242 CDS YP_904346.1 118616014 4551444 complement(113433..114212) 1 NC_008611.1 membrane protein; hypothetical protein 114212 4551444 MUL_0114 Mycobacterium ulcerans Agy99 hypothetical protein YP_904346.1 113433 R 362242 CDS YP_904347.1 118616015 4551445 complement(114216..116606) 1 NC_008611.1 cytoplasmic protein; function unknown, probably involved in cellular metabolism [catalytic activity: CO + H(2)O + acceptor = CO(2) + reduced acceptor]; carbon monoxyde dehydrogenase (large chain), CoxL 116606 coxL 4551445 coxL Mycobacterium ulcerans Agy99 carbon monoxyde dehydrogenase (large chain), CoxL YP_904347.1 114216 R 362242 CDS YP_904348.1 118616016 4551446 complement(116603..117082) 1 NC_008611.1 cytoplasmic protein; probably involved in cellular metabolism [catalytic activity: CO + H(2)O + acceptor = CO(2) + reduced acceptor]; carbon monoxyde dehydrogenase (small chain), CoxS 117082 coxS 4551446 coxS Mycobacterium ulcerans Agy99 carbon monoxyde dehydrogenase (small chain), CoxS YP_904348.1 116603 R 362242 CDS YP_904349.1 118616017 4551449 119275..120207 1 NC_008611.1 cytoplasmic protein; possibly involved in transcriptional mechanism.; LysR family transcriptional regulator 120207 4551449 MUL_0119 Mycobacterium ulcerans Agy99 LysR family transcriptional regulator YP_904349.1 119275 D 362242 CDS YP_904350.1 118616018 4552843 120225..120440 1 NC_008611.1 secreted protein; thought to be involved in protein transport (export); protein transport protein SecE2 120440 secE2 4552843 secE2 Mycobacterium ulcerans Agy99 protein transport protein SecE2 YP_904350.1 120225 D 362242 CDS YP_904351.1 118616019 4552844 complement(120549..121205) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; possibly causes methylation of RNA.; RNA methyltransferase 121205 4552844 MUL_0121 Mycobacterium ulcerans Agy99 RNA methyltransferase YP_904351.1 120549 R 362242 CDS YP_904352.1 118616020 4552845 complement(121190..122083) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; hypothetical protein 122083 4552845 MUL_0122 Mycobacterium ulcerans Agy99 hypothetical protein YP_904352.1 121190 R 362242 CDS YP_904353.1 118616021 4552846 complement(122095..122634) 1 NC_008611.1 involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate; orotate phosphoribosyltransferase 122634 pyrE 4552846 pyrE Mycobacterium ulcerans Agy99 orotate phosphoribosyltransferase YP_904353.1 122095 R 362242 CDS YP_904354.1 118616022 4552847 complement(122621..123394) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; function unknown, but possibly involvement in lipid metabolism.; ketoacyl reductase 123394 4552847 MUL_0124 Mycobacterium ulcerans Agy99 ketoacyl reductase YP_904354.1 122621 R 362242 CDS YP_904355.1 118616023 4552848 complement(123439..124293) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; hypothetical protein 124293 4552848 MUL_0125 Mycobacterium ulcerans Agy99 hypothetical protein YP_904355.1 123439 R 362242 CDS YP_904356.1 118616024 4552849 124651..125481 1 NC_008611.1 cytoplasmic protein; oxidizes fatty acids using specific components (by similarity) [catalytic activity: (3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H(2)O]; enoyl-CoA hydratase, EchA8_1 125481 echA8_1 4552849 echA8_1 Mycobacterium ulcerans Agy99 enoyl-CoA hydratase, EchA8_1 YP_904356.1 124651 D 362242 CDS YP_904357.1 118616025 4552850 complement(125478..128024) 1 NC_008611.1 Detected in the cytoplasmic fraction by LCMSMS. Also detected in the extracellular matrix and the membrane fraction by proteomics.; membrane protein; ATPase subunit of an intracellular ATP-dependent protease. in M. tuberculosis H37Rv it is regulated positively by SigH and negatively by HspR.; endopeptidase ATP binding protein (chain B) ClpB 128024 clpB 4552850 clpB Mycobacterium ulcerans Agy99 endopeptidase ATP binding protein (chain B) ClpB YP_904357.1 125478 R 362242 CDS YP_904358.1 118616026 4552851 128351..129532 1 NC_008611.1 cytoplasmic protein; function unknown, probably involved in cellular metabolism.; monooxygenase 129532 4552851 MUL_0128 Mycobacterium ulcerans Agy99 monooxygenase YP_904358.1 128351 D 362242 CDS YP_904359.1 118616027 4552852 129607..130497 1 NC_008611.1 cytoplasmic protein; possible carbohydrate transport and metabolism; hypothetical protein 130497 4552852 MUL_0129 Mycobacterium ulcerans Agy99 hypothetical protein YP_904359.1 129607 D 362242 CDS YP_904360.1 118616028 4552853 130824..131870 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 131870 4552853 MUL_0130 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_904360.1 130824 D 362242 CDS YP_904361.1 118616029 4552854 132228..133562 1 NC_008611.1 cytoplasmic protein; required for the transposition of the insertion element IS2606.; transposase for IS2606 133562 4552854 MUL_0131 Mycobacterium ulcerans Agy99 transposase for IS2606 YP_904361.1 132228 D 362242 CDS YP_904362.1 118616030 4552855 complement(133754..134947) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404. ORF is extended by 50 aa.; transposase for IS2404 134947 4552855 MUL_0132 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_904362.1 133754 R 362242 CDS YP_904363.1 118616031 4552856 135369..135608 1 NC_008611.1 cytoplasmic protein; hypothetical protein 135608 4552856 MUL_0133 Mycobacterium ulcerans Agy99 hypothetical protein YP_904363.1 135369 D 362242 CDS YP_904364.1 118616032 4552858 138020..139048 1 NC_008611.1 cytoplasmic protein; involved in transcriptional mechanism.; TetR family transcriptional regulator 139048 4552858 MUL_0135 Mycobacterium ulcerans Agy99 TetR family transcriptional regulator YP_904364.1 138020 D 362242 CDS YP_904365.1 118616033 4552859 139396..140241 1 NC_008611.1 membrane protein; function unknown, possibly involved in cellular metabolism.; short-chain type dehydrogenase/reductase 140241 4552859 MUL_0136 Mycobacterium ulcerans Agy99 short-chain type dehydrogenase/reductase YP_904365.1 139396 D 362242 CDS YP_904366.1 118616034 4552860 140258..140908 1 NC_008611.1 membrane protein; function unknown, contains NADH-flavin reductase domain; hypothetical protein 140908 4552860 MUL_0137 Mycobacterium ulcerans Agy99 hypothetical protein YP_904366.1 140258 D 362242 CDS YP_904367.1 118616035 4552861 141241..143616 1 NC_008611.1 catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine; 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 143616 metE 4552861 metE Mycobacterium ulcerans Agy99 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase YP_904367.1 141241 D 362242 CDS YP_904368.1 118616036 4552862 complement(143694..145415) 1 NC_008611.1 membrane protein; hypothetical protein 145415 4552862 MUL_0139 Mycobacterium ulcerans Agy99 hypothetical protein YP_904368.1 143694 R 362242 CDS YP_904369.1 118616037 4552863 complement(145487..145996) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; hypothetical protein 145996 4552863 MUL_0140 Mycobacterium ulcerans Agy99 hypothetical protein YP_904369.1 145487 R 362242 CDS YP_904370.1 118616038 4552864 146094..147734 1 NC_008611.1 catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate phosphate dikinase 147734 ppdK 4552864 ppdK Mycobacterium ulcerans Agy99 pyruvate phosphate dikinase YP_904370.1 146094 D 362242 CDS YP_904371.1 118616039 4552865 147731..148336 1 NC_008611.1 cytoplasmic protein; hypothetical protein 148336 4552865 MUL_0142 Mycobacterium ulcerans Agy99 hypothetical protein YP_904371.1 147731 D 362242 CDS YP_904372.1 118616040 4552867 complement(149589..150515) 1 NC_008611.1 cytoplasmic protein; thought to be involved in detoxification reactions following oxidative damage to lipids [catalytic activity: an epoxide + H(2)O = a glycol]; epoxide hydrolase EphC 150515 ephC 4552867 ephC Mycobacterium ulcerans Agy99 epoxide hydrolase EphC YP_904372.1 149589 R 362242 CDS YP_904373.1 118616041 4552868 151048..151551 1 NC_008611.1 cytoplasmic protein; involved in transcriptional mechanism.; TetR family transcriptional regulator 151551 4552868 MUL_0145 Mycobacterium ulcerans Agy99 TetR family transcriptional regulator YP_904373.1 151048 D 362242 CDS YP_904374.1 118616042 4552869 complement(151637..152113) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 152113 4552869 MUL_0146 Mycobacterium ulcerans Agy99 hypothetical protein YP_904374.1 151637 R 362242 CDS YP_904375.1 118616043 4552870 152240..153115 1 NC_008611.1 cytoplasmic protein; supposed involved in detoxification reactions.; peroxidase BpoB 153115 bpoB 4552870 bpoB Mycobacterium ulcerans Agy99 peroxidase BpoB YP_904375.1 152240 D 362242 CDS YP_904376.2 162138272 4552871 complement(153112..154134) 1 NC_008611.1 similar to full-length Gnd, these proteins seems to have a truncated C-terminal 6PGD domainin; in Methylobacillus flagellatus this gene is essential for NAD+-dependent oxidation of 6-phosphogluconate; 6-phosphogluconate dehydrogenase-like protein 154134 gnd2 4552871 gnd2 Mycobacterium ulcerans Agy99 6-phosphogluconate dehydrogenase-like protein YP_904376.2 153112 R 362242 CDS YP_904377.1 118616045 4552872 complement(154149..155165) 1 NC_008611.1 catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate; glucose-6-phosphate 1-dehydrogenase 155165 zwf1 4552872 zwf1 Mycobacterium ulcerans Agy99 glucose-6-phosphate 1-dehydrogenase YP_904377.1 154149 R 362242 CDS YP_904378.1 118616046 4552873 155832..156539 1 NC_008611.1 cytoplasmic protein; hypothetical protein 156539 4552873 MUL_0150 Mycobacterium ulcerans Agy99 hypothetical protein YP_904378.1 155832 D 362242 CDS YP_904379.1 118616047 4552874 156572..156751 1 NC_008611.1 cytoplasmic protein; hypothetical protein 156751 4552874 MUL_0151 Mycobacterium ulcerans Agy99 hypothetical protein YP_904379.1 156572 D 362242 CDS YP_904380.1 118616048 4552875 156733..157434 1 NC_008611.1 cytoplasmic protein; hypothetical protein 157434 4552875 MUL_5079 Mycobacterium ulcerans Agy99 hypothetical protein YP_904380.1 156733 D 362242 CDS YP_904381.1 118616049 4552876 complement(157531..157860) 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; hypothetical protein 157860 4552876 MUL_0152 Mycobacterium ulcerans Agy99 hypothetical protein YP_904381.1 157531 R 362242 CDS YP_904382.1 118616050 4552877 complement(157936..158232) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 158232 4552877 MUL_0153 Mycobacterium ulcerans Agy99 hypothetical protein YP_904382.1 157936 R 362242 CDS YP_904383.1 118616051 4552676 158704..160224 1 NC_008611.1 cytoplasmic protein; function unknown, probably involved in cellular metabolism.; dioxygenase 160224 4552676 MUL_0155 Mycobacterium ulcerans Agy99 dioxygenase YP_904383.1 158704 D 362242 CDS YP_904384.1 118616052 4552677 160169..160714 1 NC_008611.1 cytoplasmic protein; hypothetical protein 160714 4552677 MUL_0156 Mycobacterium ulcerans Agy99 hypothetical protein YP_904384.1 160169 D 362242 CDS YP_904385.1 118616053 4552678 complement(160720..161154) 1 NC_008611.1 membrane protein; hypothetical protein 161154 4552678 MUL_0157 Mycobacterium ulcerans Agy99 hypothetical protein YP_904385.1 160720 R 362242 CDS YP_904386.1 118616054 4552679 complement(161225..161998) 1 NC_008611.1 hypothetical protein 161998 4552679 MUL_0158 Mycobacterium ulcerans Agy99 hypothetical protein YP_904386.1 161225 R 362242 CDS YP_904387.1 118616055 4552681 complement(163531..163977) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; hypothetical protein 163977 4552681 MUL_0160 Mycobacterium ulcerans Agy99 hypothetical protein YP_904387.1 163531 R 362242 CDS YP_904388.1 118616056 4552682 complement(163982..164170) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 164170 4552682 MUL_0161 Mycobacterium ulcerans Agy99 hypothetical protein YP_904388.1 163982 R 362242 CDS YP_904389.1 118616057 4552684 165556..166890 1 NC_008611.1 cytoplasmic protein; required for the transposition of the insertion element IS2606.; transposase for IS2606 166890 4552684 MUL_0163 Mycobacterium ulcerans Agy99 transposase for IS2606 YP_904389.1 165556 D 362242 CDS YP_904390.1 118616058 4552686 complement(167198..168244) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 168244 4552686 MUL_0165 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_904390.1 167198 R 362242 CDS YP_904391.1 118616059 4552687 complement(168649..169749) 1 NC_008611.1 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1; GTP-dependent nucleic acid-binding protein EngD 169749 4552687 MUL_0166 Mycobacterium ulcerans Agy99 GTP-dependent nucleic acid-binding protein EngD YP_904391.1 168649 R 362242 CDS YP_904392.1 118616060 4552688 169882..171102 1 NC_008611.1 membrane protein; hypothetical protein 171102 4552688 MUL_0167 Mycobacterium ulcerans Agy99 hypothetical protein YP_904392.1 169882 D 362242 CDS YP_904393.1 118616061 4552689 complement(171116..172114) 1 NC_008611.1 catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway; 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 172114 ispH 4552689 ispH Mycobacterium ulcerans Agy99 4-hydroxy-3-methylbut-2-enyl diphosphate reductase YP_904393.1 171116 R 362242 CDS YP_904394.1 118616062 4552690 172224..172841 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; hypothetical protein 172841 4552690 MUL_0169 Mycobacterium ulcerans Agy99 hypothetical protein YP_904394.1 172224 D 362242 CDS YP_904395.1 118616063 4552691 172838..174085 1 NC_008611.1 bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides; exodeoxyribonuclease VII large subunit 174085 xseA 4552691 xseA Mycobacterium ulcerans Agy99 exodeoxyribonuclease VII large subunit YP_904395.1 172838 D 362242 CDS YP_904396.1 118616064 4553964 174069..174323 1 NC_008611.1 catalyzes the bidirectional exonucleolytic cleavage of DNA; exodeoxyribonuclease VII small subunit 174323 xseB 4553964 xseB Mycobacterium ulcerans Agy99 exodeoxyribonuclease VII small subunit YP_904396.1 174069 D 362242 CDS YP_904397.1 118616065 4553965 174378..175472 1 NC_008611.1 cytoplasmic protein; function unknown, probably involved in cellular metabolism; cholesterol dehydrogenase 175472 4553965 MUL_0172 Mycobacterium ulcerans Agy99 cholesterol dehydrogenase YP_904397.1 174378 D 362242 CDS YP_904398.1 118616066 4553966 175647..175910 1 NC_008611.1 cytoplasmic protein; hypothetical protein 175910 4553966 MUL_0173 Mycobacterium ulcerans Agy99 hypothetical protein YP_904398.1 175647 D 362242 CDS YP_904399.1 118616067 4553967 complement(176005..176271) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 176271 4553967 MUL_0174 Mycobacterium ulcerans Agy99 hypothetical protein YP_904399.1 176005 R 362242 CDS YP_904400.1 118616068 4553968 complement(176368..177414) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 177414 4553968 MUL_0175 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_904400.1 176368 R 362242 CDS YP_904401.1 118616069 4553970 179542..180699 1 NC_008611.1 membrane protein; hypothetical protein 180699 4553970 MUL_0177 Mycobacterium ulcerans Agy99 hypothetical protein YP_904401.1 179542 D 362242 CDS YP_904402.1 118616070 4553971 complement(180677..181477) 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; hypothetical protein 181477 4553971 MUL_0178 Mycobacterium ulcerans Agy99 hypothetical protein YP_904402.1 180677 R 362242 CDS YP_904403.1 118616071 4553972 complement(181505..182215) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; hypothetical protein 182215 4553972 MUL_0179 Mycobacterium ulcerans Agy99 hypothetical protein YP_904403.1 181505 R 362242 CDS YP_904404.1 118616072 4553973 182221..183309 1 NC_008611.1 type II fructose 1,6-bisphosphatae; in Escherichia coli this protein forms a dimer and binds manganese; fructose 1,6-bisphosphatase II 183309 glpX 4553973 glpX Mycobacterium ulcerans Agy99 fructose 1,6-bisphosphatase II YP_904404.1 182221 D 362242 CDS YP_904405.1 118616073 4553974 183347..184777 1 NC_008611.1 class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle; fumarate hydratase 184777 fumC 4553974 fumC Mycobacterium ulcerans Agy99 fumarate hydratase YP_904405.1 183347 D 362242 CDS YP_904406.1 118616074 4553975 184874..185854 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; membrane glycine and proline rich protein 185854 4553975 MUL_0182 Mycobacterium ulcerans Agy99 membrane glycine and proline rich protein YP_904406.1 184874 D 362242 CDS YP_904407.1 118616075 4553977 complement(187386..188261) 1 NC_008611.1 membrane protein; probably involved in carbohydrate degradation. may hydrolyse the glycosidic bond between two or more carbohydrates or between a carbohydrate and a non- carbohydrate moiety.; glycosyl hydrolase 188261 4553977 MUL_0184 Mycobacterium ulcerans Agy99 glycosyl hydrolase YP_904407.1 187386 R 362242 CDS YP_904408.1 118616076 4553979 complement(189626..189829) 1 NC_008611.1 hypothetical protein 189829 4553979 MUL_0186 Mycobacterium ulcerans Agy99 hypothetical protein YP_904408.1 189626 R 362242 CDS YP_904409.1 118616077 4553980 complement(189944..190771) 1 NC_008611.1 Also detected in the membrane fraction by proteomics (2D-LC-MS/MS); cytoplasmic protein; thought to catalyze the principal conversion of saturated fatty acids to unsaturated fatty acids. thought to convert stearoyl-ACP to oleoyl-ACP by introduction of a cis double bond between carbons delta-9 and delta-10 of the acyl chain [catalytic activity: stearoyl-[acyl-carrier protein] + AH2 + O2 = oleoyl-[acyl-carrier protein] + a + 2 H2O]; acyl-[acyl-carrier protein] desaturase DesA2 190771 desA2 4553980 desA2 Mycobacterium ulcerans Agy99 acyl-[acyl-carrier protein] desaturase DesA2 YP_904409.1 189944 R 362242 CDS YP_904410.1 118616078 4553981 complement(190828..192108) 1 NC_008611.1 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate; serine hydroxymethyltransferase 192108 glyA 4553981 glyA Mycobacterium ulcerans Agy99 serine hydroxymethyltransferase YP_904410.1 190828 R 362242 CDS YP_904411.1 118616079 4551412 192270..193208 1 NC_008611.1 catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis; pantothenate kinase 193208 coaA 4551412 coaA Mycobacterium ulcerans Agy99 pantothenate kinase YP_904411.1 192270 D 362242 CDS YP_904412.1 118616080 4551413 complement(193472..194452) 1 NC_008611.1 PE_PGRS20; membrane protein; PE-PGRS family protein 194452 4551413 MUL_0190 Mycobacterium ulcerans Agy99 PE-PGRS family protein YP_904412.1 193472 R 362242 CDS YP_904413.1 118616081 4551414 complement(194658..195176) 1 NC_008611.1 membrane protein; hypothetical protein 195176 4551414 MUL_0191 Mycobacterium ulcerans Agy99 hypothetical protein YP_904413.1 194658 R 362242 CDS YP_904414.1 118616082 4551415 complement(195261..196628) 1 NC_008611.1 membrane protein; hypothetical protein 196628 4551415 MUL_0192 Mycobacterium ulcerans Agy99 hypothetical protein YP_904414.1 195261 R 362242 CDS YP_904415.1 118616083 4551416 complement(196867..197682) 1 NC_008611.1 cytoplasmic protein; catalyzes the first committed step in the synthesis of decaprenyl diphosphate, a molecule which has a central role in the biosynthesis of most features of the mycobacterial cell wall. adds one isoprene unit to omega,E- geranyl diphosphate. in mycobacterium; short (C15) chain Z-isoprenyl diphosphate synthase, UppS 197682 uppS 4551416 uppS Mycobacterium ulcerans Agy99 short (C15) chain Z-isoprenyl diphosphate synthase, UppS YP_904415.1 196867 R 362242 CDS YP_904416.1 118616084 4551417 197802..198542 1 NC_008611.1 potential role involved in virulence; membrane protein; hemolysin-like protein 198542 4551417 MUL_0194 Mycobacterium ulcerans Agy99 hemolysin-like protein YP_904416.1 197802 D 362242 CDS YP_904417.1 118616085 4551418 complement(198567..198950) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 198950 4551418 MUL_0195 Mycobacterium ulcerans Agy99 hypothetical protein YP_904417.1 198567 R 362242 CDS YP_904418.1 118616086 4551419 complement(198964..200988) 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; membrane protein; transmembrane protein 200988 4551419 MUL_0196 Mycobacterium ulcerans Agy99 transmembrane protein YP_904418.1 198964 R 362242 CDS YP_904419.1 118616087 4551420 complement(200975..201274) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; hypothetical protein 201274 4551420 MUL_0197 Mycobacterium ulcerans Agy99 hypothetical protein YP_904419.1 200975 R 362242 CDS YP_904420.1 118616088 4551421 complement(201271..202143) 1 NC_008611.1 cytoplasmic protein; mycothiol-dependent detoxification enzyme, involved in mycothiol biosynthesis.; mycothiol conjugate amidase Mca 202143 mca 4551421 mca Mycobacterium ulcerans Agy99 mycothiol conjugate amidase Mca YP_904420.1 201271 R 362242 CDS YP_904421.1 118616089 4551422 202285..202719 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; hypothetical protein 202719 4551422 MUL_0199 Mycobacterium ulcerans Agy99 hypothetical protein YP_904421.1 202285 D 362242 CDS YP_904422.1 118616090 4551423 202951..203445 1 NC_008611.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreA 203445 greA 4551423 greA Mycobacterium ulcerans Agy99 transcription elongation factor GreA YP_904422.1 202951 D 362242 CDS YP_904423.1 118616091 4551424 complement(203528..204694) 1 NC_008611.1 catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine; cystathionine gamma-synthase 204694 metB 4551424 metB Mycobacterium ulcerans Agy99 cystathionine gamma-synthase YP_904423.1 203528 R 362242 CDS YP_904424.1 118616092 4551425 complement(204794..205552) 1 NC_008611.1 Detected in the membrane fraction by proteomics (2D- LC-MS/MS); membrane protein; proline-rich antigen Pra-like protein 205552 pra 4551425 pra Mycobacterium ulcerans Agy99 proline-rich antigen Pra-like protein YP_904424.1 204794 R 362242 CDS YP_904425.1 118616093 4551426 complement(205748..207142) 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS. Also detected in the membrane fraction by proteomics (LC-MS/MS); cytoplasmic protein; thought to be involved in homocysteine transulfuration [catalytic activity: L-serine + L- homocysteine = cystathionine + H2O]; cystathionine beta-synthase CBS 207142 cbs 4551426 cbs Mycobacterium ulcerans Agy99 cystathionine beta-synthase CBS YP_904425.1 205748 R 362242 CDS YP_904426.1 118616094 4551427 complement(207201..208079) 1 NC_008611.1 Detected in the cytoplasmic fraction by proteomics.; cytoplasmic protein; hydrolyses lipids; lipase LipU 208079 lipU 4551427 lipU Mycobacterium ulcerans Agy99 lipase LipU YP_904426.1 207201 R 362242 CDS YP_904427.1 118616095 4551428 208533..209477 1 NC_008611.1 secreted protein; hypothetical protein 209477 4551428 MUL_0206 Mycobacterium ulcerans Agy99 hypothetical protein YP_904427.1 208533 D 362242 CDS YP_904428.1 118616096 4551429 209587..210804 1 NC_008611.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; acetyl-CoA acetyltransferase 210804 fadA3 4551429 fadA3 Mycobacterium ulcerans Agy99 acetyl-CoA acetyltransferase YP_904428.1 209587 D 362242 CDS YP_904429.1 118616097 4551430 complement(210985..211827) 1 NC_008611.1 membrane protein; hypothetical protein 211827 4551430 MUL_0208 Mycobacterium ulcerans Agy99 hypothetical protein YP_904429.1 210985 R 362242 CDS YP_904430.1 118616098 4553912 212075..213112 1 NC_008611.1 catalyzes the formation of 3-hydroxy-2-methylpropanoate from 3-hydroxy-2-methylpropanoyl-CoA; 3-hydroxyisobutyryl-CoA hydrolase 213112 echA9 4553912 echA9 Mycobacterium ulcerans Agy99 3-hydroxyisobutyryl-CoA hydrolase YP_904430.1 212075 D 362242 CDS YP_904431.1 118616099 4553913 213124..213897 1 NC_008611.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 213897 echA8 4553913 echA8 Mycobacterium ulcerans Agy99 enoyl-CoA hydratase YP_904431.1 213124 D 362242 CDS YP_904432.1 118616100 4553914 213909..215705 1 NC_008611.1 membrane protein; hypothetical protein 215705 4553914 MUL_0211 Mycobacterium ulcerans Agy99 hypothetical protein YP_904432.1 213909 D 362242 CDS YP_904433.1 118616101 4553915 215905..217815 1 NC_008611.1 PE_PGRS9_3; membrane protein; PE-PGRS family protein 217815 4553915 MUL_0212 Mycobacterium ulcerans Agy99 PE-PGRS family protein YP_904433.1 215905 D 362242 CDS YP_904434.1 118616102 4553917 219507..220553 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 220553 4553917 MUL_0214 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_904434.1 219507 D 362242 CDS YP_904435.1 118616103 4553918 complement(221430..221813) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 221813 4553918 MUL_0215 Mycobacterium ulcerans Agy99 hypothetical protein YP_904435.1 221430 R 362242 CDS YP_904436.1 118616104 4553919 complement(221813..222388) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 222388 4553919 MUL_0216 Mycobacterium ulcerans Agy99 hypothetical protein YP_904436.1 221813 R 362242 CDS YP_904437.1 118616105 4553920 222531..222998 1 NC_008611.1 membrane protein; lipoprotein LpqV 222998 lpqV 4553920 lpqV Mycobacterium ulcerans Agy99 lipoprotein LpqV YP_904437.1 222531 D 362242 CDS YP_904438.1 118616106 4553921 223101..224165 1 NC_008611.1 cytoplasmic protein; hypothetical protein 224165 4553921 MUL_0218 Mycobacterium ulcerans Agy99 hypothetical protein YP_904438.1 223101 D 362242 CDS YP_904439.1 118616107 4553923 complement(225057..225935) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 225935 4553923 MUL_0220 Mycobacterium ulcerans Agy99 hypothetical protein YP_904439.1 225057 R 362242 CDS YP_904440.1 118616108 4553924 complement(225968..226441) 1 NC_008611.1 membrane protein; hypothetical protein 226441 4553924 MUL_0221 Mycobacterium ulcerans Agy99 hypothetical protein YP_904440.1 225968 R 362242 CDS YP_904441.1 118616109 4553926 228677..229381 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; N-term transposase for IS2404 229381 4553926 MUL_0223 Mycobacterium ulcerans Agy99 N-term transposase for IS2404 YP_904441.1 228677 D 362242 CDS YP_904442.1 118616110 4549632 229406..229723 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; C-term transposase for IS2404 229723 4549632 MUL_0224 Mycobacterium ulcerans Agy99 C-term transposase for IS2404 YP_904442.1 229406 D 362242 CDS YP_904443.1 118616111 4549633 complement(229777..230658) 1 NC_008611.1 Detected in the membrane fraction by 2D-LC-MS/MS.; cytoplasmic protein; hypothetical protein 230658 4549633 MUL_0225 Mycobacterium ulcerans Agy99 hypothetical protein YP_904443.1 229777 R 362242 CDS YP_904444.1 118616112 4549634 complement(230651..231547) 1 NC_008611.1 cytoplasmic protein; acid phosphatase precursor 231547 4549634 MUL_0226 Mycobacterium ulcerans Agy99 acid phosphatase precursor YP_904444.1 230651 R 362242 CDS YP_904445.1 118616113 4549635 complement(231548..233098) 1 NC_008611.1 cytoplasmic protein; thought to play an important role in the mineralization of sulfates [catalytic activity: a phenol sulfate + H2O = a phenol + sulfate]; arylsulfatase, AslA 233098 aslA 4549635 aslA Mycobacterium ulcerans Agy99 arylsulfatase, AslA YP_904445.1 231548 R 362242 CDS YP_904446.1 118616114 4549637 complement(234378..236009) 1 NC_008611.1 activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase 236009 fadD14 4549637 fadD14 Mycobacterium ulcerans Agy99 long-chain-fatty-acid--CoA ligase YP_904446.1 234378 R 362242 CDS YP_904447.1 118616115 4549638 complement(236131..237330) 1 NC_008611.1 hypothetical protein 237330 4549638 MUL_0230 Mycobacterium ulcerans Agy99 hypothetical protein YP_904447.1 236131 R 362242 CDS YP_904448.1 118616116 4549640 complement(237857..238903) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 238903 4549640 MUL_0232 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_904448.1 237857 R 362242 CDS YP_904449.1 118616117 4549641 complement(239476..241851) 1 NC_008611.1 membrane protein; metal cation-transporting ATPase; possibly catalyzes the transport of undeterminated metal cation with hydrolyse of ATP [catalytic activity: ATP + H(2)O + undeterminated metal cation(in) = ADP + phosphate + undeterminated metal cation(out)]; metal cation transporter ATPase p-type CtpE 241851 ctpE 4549641 ctpE Mycobacterium ulcerans Agy99 metal cation transporter ATPase p-type CtpE YP_904449.1 239476 R 362242 CDS YP_904450.1 118616118 4549643 complement(243670..244788) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; hypothetical protein 244788 4549643 MUL_0235 Mycobacterium ulcerans Agy99 hypothetical protein YP_904450.1 243670 R 362242 CDS YP_904451.1 118616119 4549644 complement(244795..245526) 1 NC_008611.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 245526 echA6 4549644 echA6 Mycobacterium ulcerans Agy99 enoyl-CoA hydratase YP_904451.1 244795 R 362242 CDS YP_904452.1 118616120 4549645 245553..247034 1 NC_008611.1 membrane protein; this protein is a component of the acetyl coenzyme a carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [catalytic activity ATP + acetyl-CoA + HCO(3)(- ) = ADP + phosphate + malonyl-CoA]; acetyl-coenzyme a carboxylase carboxyl transferase (subunit beta) AccD3 247034 accD3 4549645 accD3 Mycobacterium ulcerans Agy99 acetyl-coenzyme a carboxylase carboxyl transferase (subunit beta) AccD3 YP_904452.1 245553 D 362242 CDS YP_904453.1 118616121 4549646 248092..249591 1 NC_008611.1 C-term truncated 20aa.; membrane protein; function unknown, but maybe involved in efflux system (probably sugar or drug transport); hypothetical protein 249591 4549646 MUL_0240 Mycobacterium ulcerans Agy99 hypothetical protein YP_904453.1 248092 D 362242 CDS YP_904454.1 118616122 4549647 249613..250875 1 NC_008611.1 cytoplasmic protein; could be involved in biotin biosynthesis (at the first step) [catalytic activity: 6-carboxyhexanoyl-CoA + L- alanine = 8-amino-7-oxononanoate + CoA + CO2]; 8-amino-7-oxononanoate synthase BioF2_1 250875 bioF2_1 4549647 bioF2_1 Mycobacterium ulcerans Agy99 8-amino-7-oxononanoate synthase BioF2_1 YP_904454.1 249613 D 362242 CDS YP_904455.1 118616123 4549648 251051..251995 1 NC_008611.1 cytoplasmic protein; involved in cysteine biosynthesis [catalytic activity : O3-acetyl-L-serine + H(2)S = L-cysteine + acetate]; cysteine synthase B CysM 251995 cysM 4549648 cysM Mycobacterium ulcerans Agy99 cysteine synthase B CysM YP_904455.1 251051 D 362242 CDS YP_904456.1 118616124 4549937 complement(253251..253772) 1 NC_008611.1 cytoplasmic protein; involved in transcriptional mechanism; transcriptional regulatory protein 253772 4549937 MUL_0245 Mycobacterium ulcerans Agy99 transcriptional regulatory protein YP_904456.1 253251 R 362242 CDS YP_904457.1 118616125 4549938 254272..255651 1 NC_008611.1 cytoplasmic protein; hypothetical protein 255651 4549938 MUL_0247 Mycobacterium ulcerans Agy99 hypothetical protein YP_904457.1 254272 D 362242 CDS YP_904458.1 118616126 4549939 255802..256512 1 NC_008611.1 Also detected in the membrane fraction by proteomics (2D-LC-MS/MS); membrane protein; transcriptional regulator part of the two component regulatory system PrrA/PrrB. thought to be involved in the environmental adaptation , specifically in an early phase of the intracellular growth.; two component response transcriptional regulatory protein PrrA 256512 prrA 4549939 prrA Mycobacterium ulcerans Agy99 two component response transcriptional regulatory protein PrrA YP_904458.1 255802 D 362242 CDS YP_904459.1 118616127 4549940 256527..257867 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; sensor part of the two component regulatory system PrrA/PrrB. thought to be involved in the environmental adaptation , specifically in an early phase of the intracellular growth.; two component sensor histidine kinase PrrB 257867 prrB 4549940 prrB Mycobacterium ulcerans Agy99 two component sensor histidine kinase PrrB YP_904459.1 256527 D 362242 CDS YP_904460.1 118616128 4549942 complement(258526..258759) 1 NC_008611.1 membrane protein; hypothetical protein 258759 4549942 MUL_0251 Mycobacterium ulcerans Agy99 hypothetical protein YP_904460.1 258526 R 362242 CDS YP_904461.1 118616129 4549943 complement(258772..259770) 1 NC_008611.1 membrane protein; the protein behaved as a porin of low specific activity. structural protein that may protect the integrity of the bacterium.; outer membrane protein a OmpA 259770 ompA 4549943 ompA Mycobacterium ulcerans Agy99 outer membrane protein a OmpA YP_904461.1 258772 R 362242 CDS YP_904462.1 118616130 4549944 259883..260146 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; hypothetical protein 260146 4549944 MUL_0253 Mycobacterium ulcerans Agy99 hypothetical protein YP_904462.1 259883 D 362242 CDS YP_904463.1 118616131 4549945 260170..261744 1 NC_008611.1 cytoplasmic protein; function unknown, probably involved in cellular metabolism.; oxidoreductase 261744 4549945 MUL_0254 Mycobacterium ulcerans Agy99 oxidoreductase YP_904463.1 260170 D 362242 CDS YP_904464.1 118616132 4549946 complement(261749..263044) 1 NC_008611.1 type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH; type II citrate synthase 263044 gltA 4549946 gltA Mycobacterium ulcerans Agy99 type II citrate synthase YP_904464.1 261749 R 362242 CDS YP_904465.1 118616133 4549947 complement(263432..264901) 1 NC_008611.1 Also detected in the cytoplamic fraction by LCMSMS; membrane protein; function unknown, probably involved in cellular metabolism.; monooxygenase 264901 4549947 MUL_0256 Mycobacterium ulcerans Agy99 monooxygenase YP_904465.1 263432 R 362242 CDS YP_904466.1 118616134 4549948 complement(265165..265653) 1 NC_008611.1 cytoplasmic protein; involved in biosynthesis of pyridoxine (vitamin B6) and pyridoxal phosphate. oxidize Pnp and PMP into pyridoxal 5'-phosphate (PLP)[catalytic activity: pyridoxamine 5'-phosphate + H(2)O + O(2) = pyridoxal 5'- phosphate + NH(3) + H(2)O(2)]; pyridoxamine 5'-phosphate oxidase PdxH 265653 pdxH 4549948 pdxH Mycobacterium ulcerans Agy99 pyridoxamine 5'-phosphate oxidase PdxH YP_904466.1 265165 R 362242 CDS YP_904467.1 118616135 4549950 266751..267605 1 NC_008611.1 forms citrate from oxaloacetate and acetyl-CoA; functions in TCA cycle; citrate synthase 2 267605 citA 4549950 citA Mycobacterium ulcerans Agy99 citrate synthase 2 YP_904467.1 266751 D 362242 CDS YP_904468.1 118616136 4549952 complement(268076..269122) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 269122 4549952 MUL_0261 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_904468.1 268076 R 362242 CDS YP_904469.1 118616137 4551600 273137..273595 1 NC_008611.1 Detected in the cytoplasmic and secreted fractions by 2D-LC-MS/MS.; cytoplasmic protein; hypothetical protein 273595 4551600 MUL_0263 Mycobacterium ulcerans Agy99 hypothetical protein YP_904469.1 273137 D 362242 CDS YP_904470.1 118616138 4551601 complement(273672..275357) 1 NC_008611.1 cytoplasmic protein; serves as the first electron transfer protein in all the P450 systems [catalytic activity: reduced adrenodoxin + NADP+ = oxidized adrenodoxin + NADPH]; NADPH:adrenodoxin oxidoreductase FprB 275357 fprB 4551601 fprB Mycobacterium ulcerans Agy99 NADPH:adrenodoxin oxidoreductase FprB YP_904470.1 273672 R 362242 CDS YP_904471.1 118616139 4551602 complement(275376..276401) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 276401 4551602 MUL_0265 Mycobacterium ulcerans Agy99 hypothetical protein YP_904471.1 275376 R 362242 CDS YP_904472.1 118616140 4551603 276608..277738 1 NC_008611.1 catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; phosphoserine aminotransferase 277738 serC 4551603 serC Mycobacterium ulcerans Agy99 phosphoserine aminotransferase YP_904472.1 276608 D 362242 CDS YP_904473.1 118616141 4551604 277860..278651 1 NC_008611.1 cytoplasmic protein; hypothetical protein 278651 4551604 MUL_0267 Mycobacterium ulcerans Agy99 hypothetical protein YP_904473.1 277860 D 362242 CDS YP_904474.1 118616142 4551605 complement(278648..278935) 1 NC_008611.1 membrane protein; transmembrane protein 278935 4551605 MUL_0268 Mycobacterium ulcerans Agy99 transmembrane protein YP_904474.1 278648 R 362242 CDS YP_904475.1 118616143 4551606 complement(278932..279738) 1 NC_008611.1 cytoplasmic protein; causes methylation.; rRNA methyltransferase 279738 4551606 MUL_0269 Mycobacterium ulcerans Agy99 rRNA methyltransferase YP_904475.1 278932 R 362242 CDS YP_904476.1 118616144 4551607 complement(279768..280199) 1 NC_008611.1 cytoplasmic protein; thought to be involved in transcriptional mechanism.; MarR family transcriptional regulator 280199 4551607 MUL_0270 Mycobacterium ulcerans Agy99 MarR family transcriptional regulator YP_904476.1 279768 R 362242 CDS YP_904477.1 118616145 4551608 280458..280739 1 NC_008611.1 membrane protein; transmembrane protein 280739 4551608 MUL_0271 Mycobacterium ulcerans Agy99 transmembrane protein YP_904477.1 280458 D 362242 CDS YP_904478.1 118616146 4551609 280763..281218 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); cytoplasmic protein; hypothetical protein 281218 4551609 MUL_0272 Mycobacterium ulcerans Agy99 hypothetical protein YP_904478.1 280763 D 362242 CDS YP_904479.1 118616147 4551610 complement(281215..282018) 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; membrane protein; hypothetical protein 282018 4551610 MUL_0273 Mycobacterium ulcerans Agy99 hypothetical protein YP_904479.1 281215 R 362242 CDS YP_904480.1 118616148 4551611 282124..283833 1 NC_008611.1 membrane protein; transmembrane protein 283833 4551611 MUL_0274 Mycobacterium ulcerans Agy99 transmembrane protein YP_904480.1 282124 D 362242 CDS YP_904481.1 118616149 4551612 283830..284318 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; hypothetical protein 284318 4551612 MUL_0275 Mycobacterium ulcerans Agy99 hypothetical protein YP_904481.1 283830 D 362242 CDS YP_904482.1 118616150 4551613 284426..285280 1 NC_008611.1 cytoplasmic protein; hypothetical protein 285280 4551613 MUL_0276 Mycobacterium ulcerans Agy99 hypothetical protein YP_904482.1 284426 D 362242 CDS YP_904483.1 118616151 4551614 complement(285277..286188) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 286188 4551614 MUL_0277 Mycobacterium ulcerans Agy99 hypothetical protein YP_904483.1 285277 R 362242 CDS YP_904484.1 118616152 4551615 complement(286293..288245) 1 NC_008611.1 cytoplasmic protein; function unknown, but involved in lipid degradation.; acyl-CoA dehydrogenase FadE10 288245 fadE10 4551615 fadE10 Mycobacterium ulcerans Agy99 acyl-CoA dehydrogenase FadE10 YP_904484.1 286293 R 362242 CDS YP_904485.1 118616153 4551616 complement(288432..288986) 1 NC_008611.1 cytoplasmic protein; function unknown, thought to act in response to low temperature.; cold shock-like protein B CspB 288986 cspB 4551616 cspB Mycobacterium ulcerans Agy99 cold shock-like protein B CspB YP_904485.1 288432 R 362242 CDS YP_904486.1 118616154 4551617 289000..289404 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; hypothetical protein 289404 4551617 MUL_0280 Mycobacterium ulcerans Agy99 hypothetical protein YP_904486.1 289000 D 362242 CDS YP_904487.1 118616155 4551618 289401..290483 1 NC_008611.1 together with moaC, is involved in the conversion of a guanosine derivative (GXP) into molybdopterin precursor Z; molybdenum cofactor biosynthesis protein A 290483 moaA 4551618 moaA Mycobacterium ulcerans Agy99 molybdenum cofactor biosynthesis protein A YP_904487.1 289401 D 362242 CDS YP_904488.1 118616156 4554350 290497..290790 1 NC_008611.1 cytoplasmic protein; involved in molybdenum cofactor biosynthesis.; molybdenum cofactor biosynthesis protein D 2 MoaD2 290790 moaD2 4554350 moaD2 Mycobacterium ulcerans Agy99 molybdenum cofactor biosynthesis protein D 2 MoaD2 YP_904488.1 290497 D 362242 CDS YP_904489.1 118616157 4554351 291203..292066 1 NC_008611.1 membrane protein; function unknown. may be promote the resuscitation and growth of dormant, nongrowing cell.; resuscitation-promoting factor RpfA 292066 rpfA 4554351 rpfA Mycobacterium ulcerans Agy99 resuscitation-promoting factor RpfA YP_904489.1 291203 D 362242 CDS YP_904490.1 118616158 4554352 complement(292111..292536) 1 NC_008611.1 cytoplasmic protein; possibly a molybdenum biosynthesis cofactor. conversion of molybdopterin precursor Z into molybdopterin requires transfer of two sulfur atoms to precursor Z (to generate the dithiolene group) this is catalyzed by the converting factor composed of a small and large subunit.; molybdenum cofactor biosynthesis protein E2 MoaE2 292536 moaE2 4554352 moaE2 Mycobacterium ulcerans Agy99 molybdenum cofactor biosynthesis protein E2 MoaE2 YP_904490.1 292111 R 362242 CDS YP_904491.1 118616159 4554353 complement(292533..293018) 1 NC_008611.1 cytoplasmic protein; involved in molybdopterin biosynthesis; involved in the biosynthesis of a demolybdo-cofactor (molybdopterin), necessary for molybdo-enzymes.; molybdopterin biosynthesis Mog protein 293018 mog 4554353 mog Mycobacterium ulcerans Agy99 molybdopterin biosynthesis Mog protein YP_904491.1 292533 R 362242 CDS YP_904492.1 118616160 4554354 complement(293015..293560) 1 NC_008611.1 cytoplasmic protein; involved in the biosynthesis of molybdopterin.; molybdenum cofactor biosynthesis protein C 2 MoaC2 293560 moaC2 4554354 moaC2 Mycobacterium ulcerans Agy99 molybdenum cofactor biosynthesis protein C 2 MoaC2 YP_904492.1 293015 R 362242 CDS YP_904493.1 118616161 4554355 complement(293564..293773) 1 NC_008611.1 hypothetical protein 293773 4554355 MUL_0287 Mycobacterium ulcerans Agy99 hypothetical protein YP_904493.1 293564 R 362242 CDS YP_904494.1 118616162 4554356 293836..296094 1 NC_008611.1 hypothetical protein 296094 4554356 MUL_0288 Mycobacterium ulcerans Agy99 hypothetical protein YP_904494.1 293836 D 362242 CDS YP_904495.1 118616163 4554357 296198..297826 1 NC_008611.1 cytoplasmic protein; involved in nucleotide excision repair. has helicase activity: acts by opening DNA either around the RNA transcription start site or the DNA damage.; DNA helicase Ercc3 297826 ercc3 4554357 ercc3 Mycobacterium ulcerans Agy99 DNA helicase Ercc3 YP_904495.1 296198 D 362242 CDS YP_904496.1 118616164 4554358 complement(297938..298375) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 298375 4554358 MUL_0290 Mycobacterium ulcerans Agy99 hypothetical protein YP_904496.1 297938 R 362242 CDS YP_904497.1 118616165 4554359 298676..298996 1 NC_008611.1 membrane protein; hypothetical protein 298996 4554359 MUL_0291 Mycobacterium ulcerans Agy99 hypothetical protein YP_904497.1 298676 D 362242 CDS YP_904498.1 118616166 4554360 complement(299024..299971) 1 NC_008611.1 Detected in the membrane fraction by proteomics (2D- LC-MS/MS); membrane protein; function unknown, may have reductase activity; hypothetical protein 299971 4554360 MUL_0292 Mycobacterium ulcerans Agy99 hypothetical protein YP_904498.1 299024 R 362242 CDS YP_904499.1 118616167 4554361 complement(300077..300616) 1 NC_008611.1 cytoplasmic protein; transcriptional regulator 300616 4554361 MUL_0293 Mycobacterium ulcerans Agy99 transcriptional regulator YP_904499.1 300077 R 362242 CDS YP_904500.1 118616168 4554362 300693..301904 1 NC_008611.1 Also detected in the cytoplasmic fraction.; membrane protein; membrane-associated oxidoreductase 301904 4554362 MUL_0294 Mycobacterium ulcerans Agy99 membrane-associated oxidoreductase YP_904500.1 300693 D 362242 CDS YP_904501.1 118616169 4554363 complement(301919..304063) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS) Also detected in the extracellular matrix by proteomics.; membrane protein; involved in fatty acid degradation (probably in fatty acid beta-oxidation cycle); fatty oxidation protein FadB 304063 fadB 4554363 fadB Mycobacterium ulcerans Agy99 fatty oxidation protein FadB YP_904501.1 301919 R 362242 CDS YP_904502.1 118616170 4554364 complement(304068..305279) 1 NC_008611.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; acetyl-CoA acetyltransferase 305279 fadA 4554364 fadA Mycobacterium ulcerans Agy99 acetyl-CoA acetyltransferase YP_904502.1 304068 R 362242 CDS YP_904503.1 118616171 4554365 305484..306680 1 NC_008611.1 cytoplasmic protein; function unknown, probably involved in cellular metabolism.; aminotransferase 306680 4554365 MUL_0297 Mycobacterium ulcerans Agy99 aminotransferase YP_904503.1 305484 D 362242 CDS YP_904504.1 118616172 4554367 complement(307165..307620) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 307620 4554367 MUL_0299 Mycobacterium ulcerans Agy99 hypothetical protein YP_904504.1 307165 R 362242 CDS YP_904505.1 118616173 4554369 complement(308797..309237) 1 NC_008611.1 cytoplasmic protein; conserved hypothetical protein; hypothetical protein 309237 4554369 MUL_0301 Mycobacterium ulcerans Agy99 hypothetical protein YP_904505.1 308797 R 362242 CDS YP_904506.1 118616174 4549594 309301..311001 1 NC_008611.1 Detected in the membrane fraction by proteomics (2D- LC-MS/MS); membrane protein; possible indole-3-pyruvate decarboxylase; [catalytic activity: 3-(indol-3-YL) pyruvate = 2-(indol-3- YL)acetaldehyde + CO2], or possible pyruvate decarboxylase; [catalytic activity: a 2-oxo acid = an aldehyde + CO2]; pyruvate or indole-3-pyruvate decarboxylase Pdc 311001 pdc 4549594 pdc Mycobacterium ulcerans Agy99 pyruvate or indole-3-pyruvate decarboxylase Pdc YP_904506.1 309301 D 362242 CDS YP_904507.1 118616175 4549595 complement(311016..311201) 1 NC_008611.1 cytoplasmic protein; conserved hypothetical protein; hypothetical protein 311201 4549595 MUL_0303 Mycobacterium ulcerans Agy99 hypothetical protein YP_904507.1 311016 R 362242 CDS YP_904508.1 118616176 4549597 complement(311874..312467) 1 NC_008611.1 membrane protein; hypothetical protein 312467 4549597 MUL_0305 Mycobacterium ulcerans Agy99 hypothetical protein YP_904508.1 311874 R 362242 CDS YP_904509.1 118616177 4549598 complement(312464..313366) 1 NC_008611.1 membrane protein; hypothetical protein 313366 4549598 MUL_0306 Mycobacterium ulcerans Agy99 hypothetical protein YP_904509.1 312464 R 362242 CDS YP_904510.1 118616178 4549600 complement(315163..316344) 1 NC_008611.1 cytoplasmic protein; function unknown, contains a hydrolytic domain.; hypothetical protein 316344 4549600 MUL_0308 Mycobacterium ulcerans Agy99 hypothetical protein YP_904510.1 315163 R 362242 CDS YP_904511.1 118616179 4549601 complement(316438..316860) 1 NC_008611.1 membrane protein; lipoprotein 316860 4549601 MUL_0309 Mycobacterium ulcerans Agy99 lipoprotein YP_904511.1 316438 R 362242 CDS YP_904512.1 118616180 4549602 317004..317768 1 NC_008611.1 cytoplasmic protein; oxidizes fatty acids using specific components (by similarity) [catalytic activity: (3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H(2)O]; enoyl-CoA hydratase, EchA8_2 317768 echA8_2 4549602 echA8_2 Mycobacterium ulcerans Agy99 enoyl-CoA hydratase, EchA8_2 YP_904512.1 317004 D 362242 CDS YP_904513.1 118616181 4549603 317765..318196 1 NC_008611.1 secreted protein; hypothetical protein 318196 4549603 MUL_0311 Mycobacterium ulcerans Agy99 hypothetical protein YP_904513.1 317765 D 362242 CDS YP_904514.1 118616182 4549606 318774..319097 1 NC_008611.1 cytoplasmic protein; hypothetical protein 319097 4549606 MUL_0313 Mycobacterium ulcerans Agy99 hypothetical protein YP_904514.1 318774 D 362242 CDS YP_904515.1 118616183 4549607 complement(319116..320390) 1 NC_008611.1 cytoplasmic protein; cytochromes P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.; cytochrome P450 150A6 Cyp150A6 320390 cyp150A6 4549607 cyp150A6 Mycobacterium ulcerans Agy99 cytochrome P450 150A6 Cyp150A6 YP_904515.1 319116 R 362242 CDS YP_904516.1 118616184 4549608 320674..321405 1 NC_008611.1 membrane protein; involved in the fatty acid biosynthesis [catalytic activity: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH]; 3-oxoacyl-[acyl-carrier protein] reductase, FabG2 321405 fabG2 4549608 fabG2 Mycobacterium ulcerans Agy99 3-oxoacyl-[acyl-carrier protein] reductase, FabG2 YP_904516.1 320674 D 362242 CDS YP_904517.1 118616185 4549609 321514..321714 1 NC_008611.1 cytoplasmic protein; ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.; ferredoxin 321714 4549609 MUL_0316 Mycobacterium ulcerans Agy99 ferredoxin YP_904517.1 321514 D 362242 CDS YP_904518.1 118616186 4549610 321729..323141 1 NC_008611.1 cytoplasmic protein; cytochromes P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.; cytochrome P450 188A3 Cyp188A3 323141 cyp188A3 4549610 cyp188A3 Mycobacterium ulcerans Agy99 cytochrome P450 188A3 Cyp188A3 YP_904518.1 321729 D 362242 CDS YP_904519.1 118616187 4549612 complement(324354..325394) 1 NC_008611.1 cytoplasmic protein; function unknown, but supposed involvement in lipid degradation.; acyl-CoA dehydrogenase 325394 4549612 MUL_0319 Mycobacterium ulcerans Agy99 acyl-CoA dehydrogenase YP_904519.1 324354 R 362242 CDS YP_904520.1 118616188 4552639 325454..325954 1 NC_008611.1 cytoplasmic protein; hypothetical protein 325954 4552639 MUL_0320 Mycobacterium ulcerans Agy99 hypothetical protein YP_904520.1 325454 D 362242 CDS YP_904521.1 118616189 4552640 complement(326429..327964) 1 NC_008611.1 membrane protein; function unknown, possibly involved in transport of sulfate across the membrane.; integral membrane transporter 327964 4552640 MUL_0321 Mycobacterium ulcerans Agy99 integral membrane transporter YP_904521.1 326429 R 362242 CDS YP_904522.1 118616190 4552641 complement(328370..329452) 1 NC_008611.1 cytoplasmic protein; function unknown, but supposed involvement in lipid degradation.; acyl-CoA dehydrogenase 329452 4552641 MUL_0322 Mycobacterium ulcerans Agy99 acyl-CoA dehydrogenase YP_904522.1 328370 R 362242 CDS YP_904523.1 118616191 4552642 329643..330296 1 NC_008611.1 cytoplasmic protein; could be involved in transcriptional mechanism.; transcriptional regulatory protein 330296 4552642 MUL_0323 Mycobacterium ulcerans Agy99 transcriptional regulatory protein YP_904523.1 329643 D 362242 CDS YP_904524.1 118616192 4552643 330530..331732 1 NC_008611.1 cytoplasmic protein; cytochromes P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.; cytochrome P450 189A7 Cyp189A7 331732 cyp189A7 4552643 cyp189A7 Mycobacterium ulcerans Agy99 cytochrome P450 189A7 Cyp189A7 YP_904524.1 330530 D 362242 CDS YP_904525.1 118616193 4552645 332625..333455 1 NC_008611.1 cytoplasmic protein; function unknown, possibly involved in cellular metabolism.; short chain dehydrogenase 333455 4552645 MUL_0326 Mycobacterium ulcerans Agy99 short chain dehydrogenase YP_904525.1 332625 D 362242 CDS YP_904526.1 118616194 4552646 complement(333452..334258) 1 NC_008611.1 cytoplasmic protein; function unknown, probably involved in cellular metabolism.; oxidoreductase 334258 4552646 MUL_0327 Mycobacterium ulcerans Agy99 oxidoreductase YP_904526.1 333452 R 362242 CDS YP_904527.1 118616195 4552647 complement(334267..336705) 1 NC_008611.1 cytoplasmic protein; acyl-CoA transferase 336705 4552647 MUL_0328 Mycobacterium ulcerans Agy99 acyl-CoA transferase YP_904527.1 334267 R 362242 CDS YP_904528.1 118616196 4552649 complement(337700..338818) 1 NC_008611.1 membrane protein; function unknown, hydrolyses peptides.; aminopeptidase 338818 4552649 MUL_0330 Mycobacterium ulcerans Agy99 aminopeptidase YP_904528.1 337700 R 362242 CDS YP_904529.1 118616197 4552650 complement(338808..339977) 1 NC_008611.1 cytoplasmic protein; hydrolysis of peptide bonds; dipeptidase 339977 4552650 MUL_0331 Mycobacterium ulcerans Agy99 dipeptidase YP_904529.1 338808 R 362242 CDS YP_904530.1 118616198 4552652 complement(341262..342506) 1 NC_008611.1 cytoplasmic protein; cytochromes P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.; cytochrome P450 105Q4 Cyp105Q4 342506 cyp105Q4 4552652 cyp105Q4 Mycobacterium ulcerans Agy99 cytochrome P450 105Q4 Cyp105Q4 YP_904530.1 341262 R 362242 CDS YP_904531.1 118616199 4552653 complement(342509..342703) 1 NC_008611.1 cytoplasmic protein; ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.; ferredoxin 342703 4552653 MUL_0334 Mycobacterium ulcerans Agy99 ferredoxin YP_904531.1 342509 R 362242 CDS YP_904532.1 118616200 4552654 complement(342716..343381) 1 NC_008611.1 cytoplasmic protein; function unknown, maybe a transcriptional regulator; hypothetical protein 343381 4552654 MUL_0335 Mycobacterium ulcerans Agy99 hypothetical protein YP_904532.1 342716 R 362242 CDS YP_904533.1 118616201 4552655 complement(343471..344274) 1 NC_008611.1 cytoplasmic protein; short chain dehydrogenase 344274 4552655 MUL_0336 Mycobacterium ulcerans Agy99 short chain dehydrogenase YP_904533.1 343471 R 362242 CDS YP_904534.1 118616202 4552657 complement(345276..346553) 1 NC_008611.1 membrane protein; thought to be involved in transport of undeterminated substrate (possibly drug) across the membrane. responsible for the translocation of the substrate across the membrane.; integral membrane transport protein 346553 4552657 MUL_0338 Mycobacterium ulcerans Agy99 integral membrane transport protein YP_904534.1 345276 R 362242 CDS YP_904535.1 118616203 4550871 complement(347877..348293) 1 NC_008611.1 membrane protein; lipoprotein LpqS 348293 lpqS 4550871 lpqS Mycobacterium ulcerans Agy99 lipoprotein LpqS YP_904535.1 347877 R 362242 CDS YP_904536.1 118616204 4550872 348414..350072 1 NC_008611.1 Also detected in the cytoplasmic and the membrane fraction by proteomics..; membrane protein; probable oxidase, showing similarity with several oxidases, mainly L-ascorbate oxidases and copper resistance proteins; oxidase 350072 4550872 MUL_0341 Mycobacterium ulcerans Agy99 oxidase YP_904536.1 348414 D 362242 CDS YP_904537.1 118616205 4550873 complement(350103..350921) 1 NC_008611.1 Transmembrane helix. Detected in the membrane and the extracellular fractions by proteomics; membrane protein; function unknown, predicted hydrolase or acyltransferase domain.; hypothetical protein 350921 4550873 MUL_0342 Mycobacterium ulcerans Agy99 hypothetical protein YP_904537.1 350103 R 362242 CDS YP_904538.1 118616206 4550874 complement(350921..351913) 1 NC_008611.1 Detected in the membrane fraction by proteomics (2D- LC-MS/MS) Also detected in the cytoplamic fraction by LC- MS/MS; cytoplasmic protein; putative cyclase; hypothetical protein 351913 4550874 MUL_0343 Mycobacterium ulcerans Agy99 hypothetical protein YP_904538.1 350921 R 362242 CDS YP_904539.1 118616207 4550875 complement(351910..352725) 1 NC_008611.1 catalyzes the formation of 5-alpha-androstane-3,17-dione from androsterone; Acts on other 3-alpha-hydroxysteroids and on 9-, 11- and 15-hydroxyprostaglandin.; 3-alpha-hydroxysteroid dehydrogenase 352725 4550875 MUL_0344 Mycobacterium ulcerans Agy99 3-alpha-hydroxysteroid dehydrogenase YP_904539.1 351910 R 362242 CDS YP_904540.1 118616208 4550876 complement(352760..354061) 1 NC_008611.1 cytoplasmic protein; monoxygenase 354061 4550876 MUL_0345 Mycobacterium ulcerans Agy99 monoxygenase YP_904540.1 352760 R 362242 CDS YP_904541.1 118616209 4550877 complement(354064..355818) 1 NC_008611.1 initiates steroid ring degradation; catalyzes the transhydrogenation of 3-keto-4-ene-steroid to 3-keto-1,4-diene-steroid e.g., progesterone to 1,4-androstadiene-3,17-dione; 3-ketosteroid-delta-1-dehydrogenase 355818 4550877 MUL_0346 Mycobacterium ulcerans Agy99 3-ketosteroid-delta-1-dehydrogenase YP_904541.1 354064 R 362242 CDS YP_904542.1 118616210 4550878 complement(355815..356645) 1 NC_008611.1 catalyzes the cleavage of 3-(2,3-dihydroxyphenyl) propionate into 2-hydroxy-6-oxonona-2,4-diene-1,9-dioate; part of the 3-phenylpropionic acid degradation pathway; member of the protocatechuate 4,5-dioxygenase family; 3-(2,3-dihydroxyphenyl)propionate dioxygenase 356645 mhpB 4550878 mhpB Mycobacterium ulcerans Agy99 3-(2,3-dihydroxyphenyl)propionate dioxygenase YP_904542.1 355815 R 362242 CDS YP_904543.1 118616211 4550879 357322..357999 1 NC_008611.1 cytoplasmic protein; involved in transcriptional mechanism.; transcriptional regulatory protein 357999 4550879 MUL_0348 Mycobacterium ulcerans Agy99 transcriptional regulatory protein YP_904543.1 357322 D 362242 CDS YP_904544.1 118616212 4550880 358017..359627 1 NC_008611.1 membrane protein; dehydrogenase 359627 4550880 MUL_0349 Mycobacterium ulcerans Agy99 dehydrogenase YP_904544.1 358017 D 362242 CDS YP_904545.1 118616213 4550881 complement(359634..361028) 1 NC_008611.1 membrane protein; possible sensor part of a two component regulatory system; two component sensor kinase 361028 4550881 MUL_0350 Mycobacterium ulcerans Agy99 two component sensor kinase YP_904545.1 359634 R 362242 CDS YP_904546.1 118616214 4550882 361076..361726 1 NC_008611.1 cytoplasmic protein; nitrate/nitrite response regulator protein NarL 361726 narL 4550882 narL Mycobacterium ulcerans Agy99 nitrate/nitrite response regulator protein NarL YP_904546.1 361076 D 362242 CDS YP_904547.1 118616215 4550885 complement(364334..365872) 1 NC_008611.1 membrane protein; integral membrane protein 365872 4550885 MUL_0354 Mycobacterium ulcerans Agy99 integral membrane protein YP_904547.1 364334 R 362242 CDS YP_904548.1 118616216 4550886 complement(365985..366284) 1 NC_008611.1 membrane protein; PE-PGRS family protein family protein 366284 4550886 MUL_0355 Mycobacterium ulcerans Agy99 PE-PGRS family protein family protein YP_904548.1 365985 R 362242 CDS YP_904549.1 118616217 4550887 complement(366373..367251) 1 NC_008611.1 membrane protein; transport system kinase - possibly arginine; transport system kinase 367251 4550887 MUL_0356 Mycobacterium ulcerans Agy99 transport system kinase YP_904549.1 366373 R 362242 CDS YP_904550.1 118616218 4550888 complement(367269..368468) 1 NC_008611.1 cytoplasmic protein; function unknown but may be involved in fatty acid oxidation (BetA oxidation); beta-ketoacyl CoA thiolase 368468 4550888 MUL_0357 Mycobacterium ulcerans Agy99 beta-ketoacyl CoA thiolase YP_904550.1 367269 R 362242 CDS YP_904551.1 118616219 4554388 368579..369409 1 NC_008611.1 cytoplasmic protein; specifically catalyzes the removal of N-terminal proline residues from peptides. thought to release the N- terminal proline from the dipeptides, pro-pro, pro-gln, pro-trp and pro-tyr; also from amides (pro-beta na) and oligopeptides, pro-leu-glynH2, pro-leu-gly and pro-phe-gly- lys. higher activity toward small peptides (up to three residues), but very low activity for longer peptides [catalytic activity: release of a N-terminal proline from a peptide]; proline iminopeptidase PIP 369409 pip 4554388 pip Mycobacterium ulcerans Agy99 proline iminopeptidase PIP YP_904551.1 368579 D 362242 CDS YP_904552.1 118616220 4554389 complement(369438..370205) 1 NC_008611.1 cytoplasmic protein; lipid metabolism; enoyl-CoA hydratase 370205 4554389 MUL_0359 Mycobacterium ulcerans Agy99 enoyl-CoA hydratase YP_904552.1 369438 R 362242 CDS YP_904553.1 118616221 4554390 complement(370207..371097) 1 NC_008611.1 cytoplasmic protein; involved in lipid metabolism.; acyl-CoA dehydrogenase 371097 4554390 MUL_0360 Mycobacterium ulcerans Agy99 acyl-CoA dehydrogenase YP_904553.1 370207 R 362242 CDS YP_904554.1 118616222 4554391 complement(371291..372160) 1 NC_008611.1 cytoplasmic protein; involved in lipid metabolism.; acyl-CoA dehydrogenase 372160 4554391 MUL_0361 Mycobacterium ulcerans Agy99 acyl-CoA dehydrogenase YP_904554.1 371291 R 362242 CDS YP_904555.1 118616223 4554392 complement(372175..373710) 1 NC_008611.1 cytoplasmic protein; acyl-CoA synthetase 373710 4554392 MUL_0362 Mycobacterium ulcerans Agy99 acyl-CoA synthetase YP_904555.1 372175 R 362242 CDS YP_904556.1 118616224 4554393 373694..373975 1 NC_008611.1 cytoplasmic protein; similar to ferredoxin reductase electron transfer proteins; electron transfer protein 373975 4554393 MUL_0363 Mycobacterium ulcerans Agy99 electron transfer protein YP_904556.1 373694 D 362242 CDS YP_904557.1 118616225 4554394 complement(374075..375046) 1 NC_008611.1 cytoplasmic protein; acyl-CoA transferase 375046 4554394 MUL_0364 Mycobacterium ulcerans Agy99 acyl-CoA transferase YP_904557.1 374075 R 362242 CDS YP_904558.1 118616226 4554395 complement(375043..375999) 1 NC_008611.1 cytoplasmic protein; oxidoreductase 375999 4554395 MUL_0365 Mycobacterium ulcerans Agy99 oxidoreductase YP_904558.1 375043 R 362242 CDS YP_904559.1 118616227 4554396 complement(375984..376421) 1 NC_008611.1 cytoplasmic protein; involved in propionic acid fermentation. catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid- cycle intermediates [catalytic activity : (R)-2-methyl-3- oxopropanoyl-CoA = succinyl- CoA]; methylmalonyl-CoA mutase alpha subunit, McmA2b 376421 mcmA2b 4554396 mcmA2b Mycobacterium ulcerans Agy99 methylmalonyl-CoA mutase alpha subunit, McmA2b YP_904559.1 375984 R 362242 CDS YP_904560.1 118616228 4554397 complement(376422..377999) 1 NC_008611.1 cytoplasmic protein; catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates [catalytic activity : (R)-2-methyl-3-oxopropanoyl-CoA = succinyl- CoA] the enzyme methylmalonyl-CoA mutase is a member of a class of enzymes that uses coenzyme B12 (adenosylcobalamin) as a cofactor. the enzyme induces the formation of an adenosyl radical from the cofactor. this radical then initiates a free-radical rearrangement of its substrate, succinyl-CoA, to methylmalonyl-CoA.; methylmalonyl-CoA mutase beta subunit, McmA2a 377999 mcmA2a 4554397 mcmA2a Mycobacterium ulcerans Agy99 methylmalonyl-CoA mutase beta subunit, McmA2a YP_904560.1 376422 R 362242 CDS YP_904561.1 118616229 4554398 complement(378125..378937) 1 NC_008611.1 cytoplasmic protein; possible methylase; hypothetical protein 378937 4554398 MUL_0368 Mycobacterium ulcerans Agy99 hypothetical protein YP_904561.1 378125 R 362242 CDS YP_904562.1 118616230 4554399 complement(378998..379807) 1 NC_008611.1 membrane protein; lipoprotein, LpqR 379807 lpqR 4554399 lpqR Mycobacterium ulcerans Agy99 lipoprotein, LpqR YP_904562.1 378998 R 362242 CDS YP_904563.1 118616231 4554400 complement(379918..380811) 1 NC_008611.1 cytoplasmic protein; transposase for IS2404; transposase for IS2404 380811 4554400 MUL_0370 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_904563.1 379918 R 362242 CDS YP_904564.1 118616232 4554402 381870..382724 1 NC_008611.1 secreted protein; function unknown, contains a N-term cellobiohydrolase a (1,4-beta-cellobiosidase a) domain and a C-term cellulose-binding domain (CBD) domain. the CBD is found either at the N-term or at the C-terminal extremity of endoglucanases, cellobiohydrolases (exoglucanases), or xylanases; chitinase/cellulase 382724 4554402 MUL_0371 Mycobacterium ulcerans Agy99 chitinase/cellulase YP_904564.1 381870 D 362242 CDS YP_904565.1 118616233 4554403 complement(382743..383321) 1 NC_008611.1 membrane protein; hypothetical protein 383321 4554403 MUL_0372 Mycobacterium ulcerans Agy99 hypothetical protein YP_904565.1 382743 R 362242 CDS YP_904566.1 118616234 4554404 383720..384712 1 NC_008611.1 cytoplasmic protein; converts farensyl pyrophosphate to geranylgeranyl pyrophosphate, the latter being the substrate for CrtB in the production of phytoene during carotenoid synthesis; geranylgeranyl pyrophosphate synthase CrtE 384712 crtE 4554404 crtE Mycobacterium ulcerans Agy99 geranylgeranyl pyrophosphate synthase CrtE YP_904566.1 383720 D 362242 CDS YP_904567.1 118616235 4554406 386470..387429 1 NC_008611.1 cytoplasmic protein; part of carotenoid biosynthesis cluster - photochromogenesis; phytoene synthase, CrtB 387429 crtB 4554406 crtB Mycobacterium ulcerans Agy99 phytoene synthase, CrtB YP_904567.1 386470 D 362242 CDS YP_904568.1 118616236 4552709 387426..387749 1 NC_008611.1 membrane protein; involved in carotenoid biosynthesis; lycopene cyclase, CrtYc 387749 crtYc 4552709 crtYc Mycobacterium ulcerans Agy99 lycopene cyclase, CrtYc YP_904568.1 387426 D 362242 CDS YP_904569.1 118616237 4552710 387746..388120 1 NC_008611.1 cytoplasmic protein; involved in carotenoid biosynthesis; lycopene cyclase, CrtYd 388120 crtYd 4552710 crtYd Mycobacterium ulcerans Agy99 lycopene cyclase, CrtYd YP_904569.1 387746 D 362242 CDS YP_904570.1 118616238 4552712 390469..391020 1 NC_008611.1 cytoplasmic protein; involved in transcriptional mechanism.; MarR family transcriptional regulator 391020 4552712 MUL_0379 Mycobacterium ulcerans Agy99 MarR family transcriptional regulator YP_904570.1 390469 D 362242 CDS YP_904571.1 118616239 4552713 complement(391030..392076) 1 NC_008611.1 catalyzes the isomerization of isopentenyl pyrophosphate to dimethylallyl diphosphate; isopentenyl pyrophosphate isomerase 392076 idi2 4552713 idi2 Mycobacterium ulcerans Agy99 isopentenyl pyrophosphate isomerase YP_904571.1 391030 R 362242 CDS YP_904572.1 118616240 4552714 complement(392191..392898) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 392898 4552714 MUL_0381 Mycobacterium ulcerans Agy99 hypothetical protein YP_904572.1 392191 R 362242 CDS YP_904573.1 118616241 4552715 complement(392892..393494) 1 NC_008611.1 membrane protein; hypothetical protein 393494 4552715 MUL_0382 Mycobacterium ulcerans Agy99 hypothetical protein YP_904573.1 392892 R 362242 CDS YP_904574.1 118616242 4552716 complement(393576..395060) 1 NC_008611.1 membrane protein; involved in L-asparagine transport; L-asparagine permease AnsP1 395060 ansP1 4552716 ansP1 Mycobacterium ulcerans Agy99 L-asparagine permease AnsP1 YP_904574.1 393576 R 362242 CDS YP_904575.1 118616243 4552717 complement(395104..395346) 1 NC_008611.1 membrane protein; hypothetical protein 395346 4552717 MUL_0384 Mycobacterium ulcerans Agy99 hypothetical protein YP_904575.1 395104 R 362242 CDS YP_904576.1 118616244 4552718 complement(395662..396096) 1 NC_008611.1 membrane protein; function unknown, predicted ATPase domain; hypothetical protein 396096 4552718 MUL_0385 Mycobacterium ulcerans Agy99 hypothetical protein YP_904576.1 395662 R 362242 CDS YP_904577.1 118616245 4552720 397144..398190 1 NC_008611.1 cytoplasmic protein; transposase for IS2404; transposase for IS2404 398190 4552720 MUL_0387 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_904577.1 397144 D 362242 CDS YP_904578.1 118616246 4552722 399429..400643 1 NC_008611.1 cytoplasmic protein; contains amidohydrolase domain; hypothetical protein 400643 4552722 MUL_0389 Mycobacterium ulcerans Agy99 hypothetical protein YP_904578.1 399429 D 362242 CDS YP_904579.1 118616247 4552724 402249..403910 1 NC_008611.1 membrane protein; PE-PGRS family protein 403910 4552724 MUL_0391 Mycobacterium ulcerans Agy99 PE-PGRS family protein YP_904579.1 402249 D 362242 CDS YP_904580.1 118616248 4552725 complement(404179..404382) 1 NC_008611.1 Detected in the secreted fraction by 2D-LC-MS/MS.; secreted protein; possibly involved in cold acclimatization processes (the production of the protein is supposed predominantly induced at low temperatures); cold shock protein a, CspA 404382 cspA 4552725 cspA Mycobacterium ulcerans Agy99 cold shock protein a, CspA YP_904580.1 404179 R 362242 CDS YP_904581.1 118616249 4552726 complement(404475..406049) 1 NC_008611.1 cytoplasmic protein; function unknown, possibly involved in ATP- dependent RNA unwinding, enzymes of this class are needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation.; ATP-dependent RNA helicase, RhlE1 406049 rhlE1 4552726 rhlE1 Mycobacterium ulcerans Agy99 ATP-dependent RNA helicase, RhlE1 YP_904581.1 404475 R 362242 CDS YP_904582.1 118616250 4553945 406250..406399 1 NC_008611.1 cytoplasmic protein; hypothetical protein 406399 4553945 MUL_0394 Mycobacterium ulcerans Agy99 hypothetical protein YP_904582.1 406250 D 362242 CDS YP_904583.1 118616251 4553946 406789..410622 1 NC_008611.1 one of two methionine synthases in Escherichia coli; MetH catalyzes a methyl transfer reaction from methyltetrahydrofolate to homocysteine to create methionine; requires zinc for activity; B12-dependent methionine synthase 410622 metH 4553946 metH Mycobacterium ulcerans Agy99 B12-dependent methionine synthase YP_904583.1 406789 D 362242 CDS YP_904584.1 118616252 4553947 411028..411759 1 NC_008611.1 cytoplasmic protein; contains a nucleotidyltransferase domain; hypothetical protein 411759 4553947 MUL_0396 Mycobacterium ulcerans Agy99 hypothetical protein YP_904584.1 411028 D 362242 CDS YP_904585.1 118616253 4553948 411698..412234 1 NC_008611.1 cytoplasmic protein; hypothetical protein 412234 4553948 MUL_0397 Mycobacterium ulcerans Agy99 hypothetical protein YP_904585.1 411698 D 362242 CDS YP_904586.1 118616254 4553949 412514..413560 1 NC_008611.1 cytoplasmic protein; transposase for IS2404; transposase for IS2404 413560 4553949 MUL_0398 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_904586.1 412514 D 362242 CDS YP_904587.1 118616255 4553950 complement(413626..414087) 1 NC_008611.1 membrane protein; PPE family protein 414087 4553950 MUL_0399 Mycobacterium ulcerans Agy99 PPE family protein YP_904587.1 413626 R 362242 CDS YP_904588.1 118616256 4553951 414410..414655 1 NC_008611.1 With PurL and PurQ catalyzes the conversion of formylglycinamide ribonucleotide, ATP, and glutamine to formylglycinamidine ribonucleotide, ADP, and glutamate in the fourth step of the purine biosynthetic pathway; phosphoribosylformylglycinamidine synthase subunit PurS 414655 4553951 MUL_0400 Mycobacterium ulcerans Agy99 phosphoribosylformylglycinamidine synthase subunit PurS YP_904588.1 414410 D 362242 CDS YP_904589.1 118616257 4553952 414652..415326 1 NC_008611.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis; phosphoribosylformylglycinamidine synthase I 415326 purQ 4553952 purQ Mycobacterium ulcerans Agy99 phosphoribosylformylglycinamidine synthase I YP_904589.1 414652 D 362242 CDS YP_904590.1 118616258 4553953 complement(415338..415802) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 415802 4553953 MUL_0402 Mycobacterium ulcerans Agy99 hypothetical protein YP_904590.1 415338 R 362242 CDS YP_904591.1 118616259 4553954 complement(415903..416367) 1 NC_008611.1 cytoplasmic protein; contains mannose-6-phosphate isomerase [carbohydrate transport and metabolism]; hypothetical protein 416367 4553954 MUL_0403 Mycobacterium ulcerans Agy99 hypothetical protein YP_904591.1 415903 R 362242 CDS YP_904592.1 118616260 4553955 complement(416393..417925) 1 NC_008611.1 cytoplasmic protein; contains pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component domain; dihydrolipoamide dehydrogenase, LpdB 417925 lpdB 4553955 lpdB Mycobacterium ulcerans Agy99 dihydrolipoamide dehydrogenase, LpdB YP_904592.1 416393 R 362242 CDS YP_904593.1 118616261 4553956 complement(418436..419242) 1 NC_008611.1 Also detected in the extracellular matrix and membrane fraction by proteomics.; secreted protein; function unknown, high domain homology to Linocin_M18, Linocin_M18 bacteriocin protein. the Linocin_M18 region is found mostly in eubacteria, though homologous sequences have been identified in archaea; 29 kDa antigen Cfp29 419242 cfp29 4553956 cfp29 Mycobacterium ulcerans Agy99 29 kDa antigen Cfp29 YP_904593.1 418436 R 362242 CDS YP_904594.1 118616262 4553957 complement(419239..420246) 1 NC_008611.1 membrane protein; contains Dyp-type peroxidase domain. this family of dye-decolourising peroxidases lack a typical heme-binding region; hypothetical protein 420246 4553957 MUL_0406 Mycobacterium ulcerans Agy99 hypothetical protein YP_904594.1 419239 R 362242 CDS YP_904595.1 118616263 4553960 complement(422006..422656) 1 NC_008611.1 cytoplasmic protein; domain similarity with acetyltransferases; hypothetical protein 422656 4553960 MUL_0409 Mycobacterium ulcerans Agy99 hypothetical protein YP_904595.1 422006 R 362242 CDS YP_904596.1 118616264 4553961 422754..425051 1 NC_008611.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis; phosphoribosylformylglycinamidine synthase II 425051 purL 4553961 purL Mycobacterium ulcerans Agy99 phosphoribosylformylglycinamidine synthase II YP_904596.1 422754 D 362242 CDS YP_904597.1 118616265 4553962 425084..425698 1 NC_008611.1 secreted protein; contains CAAX amino terminal protease domain. members of this family are probably proteases; the family contains CAAX prenyl protease. the proteins contain a highly conserved Glu-Glu motif at the amino End of the alignment. the alignment also contains two histidine residues that may be involved in zinc binding; hypothetical protein 425698 4553962 MUL_0411 Mycobacterium ulcerans Agy99 hypothetical protein YP_904597.1 425084 D 362242 CDS YP_904598.1 118616266 4553963 425738..426706 1 NC_008611.1 cytoplasmic protein; contains phosphohydrolase domain; hypothetical protein 426706 4553963 MUL_0412 Mycobacterium ulcerans Agy99 hypothetical protein YP_904598.1 425738 D 362242 CDS YP_904599.1 118616267 4551766 complement(426651..428249) 1 NC_008611.1 cytoplasmic protein; thought to be involved in exopolysaccharide and/or lipopolysaccharide biosynthetic pathway [catalytic activity: UDP-glucose = UDP-galactose]; UDP-glucose-4-epimerase, CpsY 428249 cpsY 4551766 cpsY Mycobacterium ulcerans Agy99 UDP-glucose-4-epimerase, CpsY YP_904599.1 426651 R 362242 CDS YP_904600.1 118616268 4551768 complement(429782..430987) 1 NC_008611.1 membrane protein; MCE-family protein Mce2A 430987 mce2A 4551768 mce2A Mycobacterium ulcerans Agy99 MCE-family protein Mce2A YP_904600.1 429782 R 362242 CDS YP_904601.1 118616269 4551769 431007..431396 1 NC_008611.1 cytoplasmic protein; hypothetical protein 431396 4551769 MUL_0416 Mycobacterium ulcerans Agy99 hypothetical protein YP_904601.1 431007 D 362242 CDS YP_904602.1 118616270 4551770 431421..433061 1 NC_008611.1 Catalyzes first step of the de novo purine nucleotide biosynthetic pathway; amidophosphoribosyltransferase 433061 purF 4551770 purF Mycobacterium ulcerans Agy99 amidophosphoribosyltransferase YP_904602.1 431421 D 362242 CDS YP_904603.1 118616271 4551771 433065..434228 1 NC_008611.1 catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis; phosphoribosylaminoimidazole synthetase 434228 purM 4551771 purM Mycobacterium ulcerans Agy99 phosphoribosylaminoimidazole synthetase YP_904603.1 433065 D 362242 CDS YP_904604.1 118616272 4551772 complement(434279..434458) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 434458 4551772 MUL_0419 Mycobacterium ulcerans Agy99 hypothetical protein YP_904604.1 434279 R 362242 CDS YP_904605.1 118616273 4551773 complement(434617..435708) 1 NC_008611.1 cytoplasmic protein; contains predicted aminomethyltransferase domain, related to GcvT - involved in the catabolism of glycine; hypothetical protein 435708 4551773 MUL_0420 Mycobacterium ulcerans Agy99 hypothetical protein YP_904605.1 434617 R 362242 CDS YP_904606.1 118616274 4551775 complement(436343..438676) 1 NC_008611.1 membrane protein; metal cation-transporting ATPase; possibly catalyzes the transport of undetermined metal cation with hydrolyse of ATP [catalytic activity: ATP + H(2)O + undetermined metal cation(in) = ADP + phosphate + undetermined metal cation (out)]; metal cation transporter p-type ATPase, CtpV 438676 ctpV 4551775 ctpV Mycobacterium ulcerans Agy99 metal cation transporter p-type ATPase, CtpV YP_904606.1 436343 R 362242 CDS YP_904607.1 118616275 4551776 complement(438732..439040) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 439040 4551776 MUL_0424 Mycobacterium ulcerans Agy99 hypothetical protein YP_904607.1 438732 R 362242 CDS YP_904608.1 118616276 4551777 complement(439142..439528) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 439528 4551777 MUL_0425 Mycobacterium ulcerans Agy99 hypothetical protein YP_904608.1 439142 R 362242 CDS YP_904609.1 118616277 4551778 439630..440520 1 NC_008611.1 catalyzes the formation of 4-aminobenzoate and pyruvate from 4-amino-4-deoxychorismate; 4-amino-4-deoxychorismate lyase 440520 pabC 4551778 pabC Mycobacterium ulcerans Agy99 4-amino-4-deoxychorismate lyase YP_904609.1 439630 D 362242 CDS YP_904610.1 118616278 4551780 complement(443275..443859) 1 NC_008611.1 cytoplasmic protein; N-terminal truncated in relation to orthologs; hypothetical protein 443859 4551780 MUL_0429 Mycobacterium ulcerans Agy99 hypothetical protein YP_904610.1 443275 R 362242 CDS YP_904611.1 118616279 4551781 complement(443942..444040) 1 NC_008611.1 membrane protein; no H37Rv ortholog - very small, doubtful ORF; hypothetical protein 444040 4551781 MUL_0430 Mycobacterium ulcerans Agy99 hypothetical protein YP_904611.1 443942 R 362242 CDS YP_904612.1 118616280 4551782 complement(444097..444399) 1 NC_008611.1 cytoplasmic protein; sulphur metabolism protein, SseC2 444399 sseC2 4551782 sseC2 Mycobacterium ulcerans Agy99 sulphur metabolism protein, SseC2 YP_904612.1 444097 R 362242 CDS YP_904613.1 118616281 4551783 complement(444401..445243) 1 NC_008611.1 Also detected in the membrane fraction by proteomics.; cytoplasmic protein; may be a sulfotransferase involved in the formation of thiosulfate [catalytic activity: thiosulfate + cyanide = sulfite + thiocyanate]; thiosulfate sulfurtransferase, CysA2 445243 cysA2 4551783 cysA2 Mycobacterium ulcerans Agy99 thiosulfate sulfurtransferase, CysA2 YP_904613.1 444401 R 362242 CDS YP_904614.1 118616282 4551784 complement(445281..445748) 1 NC_008611.1 membrane protein; integral membrane protein 445748 4551784 MUL_0433 Mycobacterium ulcerans Agy99 integral membrane protein YP_904614.1 445281 R 362242 CDS YP_904615.1 118616283 4549973 complement(446048..446860) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; hypothetical protein 446860 4549973 MUL_0434 Mycobacterium ulcerans Agy99 hypothetical protein YP_904615.1 446048 R 362242 CDS YP_904616.1 118616284 4549974 447264..448031 1 NC_008611.1 cytoplasmic protein; involved in transcriptional mechanism.; transcriptional regulatory protein 448031 4549974 MUL_0435 Mycobacterium ulcerans Agy99 transcriptional regulatory protein YP_904616.1 447264 D 362242 CDS YP_904617.1 118616285 4549975 448028..448990 1 NC_008611.1 cytoplasmic protein; involved in the fourth step of mycothiol biosynthesis; mycothiol acetyltransferase, MshD 448990 mshD 4549975 mshD Mycobacterium ulcerans Agy99 mycothiol acetyltransferase, MshD YP_904617.1 448028 D 362242 CDS YP_904618.1 118616286 4549976 449127..450233 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; involved in phosphate transport; phosphate-binding protein 3 precursor, PhoS3 450233 phoS3 4549976 phoS3 Mycobacterium ulcerans Agy99 phosphate-binding protein 3 precursor, PhoS3 YP_904618.1 449127 D 362242 CDS YP_904619.1 118616287 4549978 451319..452227 1 NC_008611.1 membrane protein; nvolved in active transport of inorganic phosphate across the membrane (import); responsible for the translocation of the substrate across the membrane. this is one of the proteins required for binding-protein- mediated phosphate transport.; phosphate-transport integral membrane ABC transporter, PstA 452227 pstA 4549978 pstA Mycobacterium ulcerans Agy99 phosphate-transport integral membrane ABC transporter, PstA YP_904619.1 451319 D 362242 CDS YP_904620.1 118616288 4549979 452247..453023 1 NC_008611.1 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation; phosphate transporter ATP-binding protein 453023 phoT 4549979 phoT Mycobacterium ulcerans Agy99 phosphate transporter ATP-binding protein YP_904620.1 452247 D 362242 CDS YP_904621.1 118616289 4549980 complement(453058..453726) 1 NC_008611.1 Detected in the membrane fraction by proteomics (2D- LC-MS/MS); cytoplasmic protein; involved in transcriptional regulation of active transport of inorganic phosphate across the membrane; phosphate-transport system regulatory protein, PhoY2 453726 phoY2 4549980 phoY2 Mycobacterium ulcerans Agy99 phosphate-transport system regulatory protein, PhoY2 YP_904621.1 453058 R 362242 CDS YP_904622.1 118616290 4549982 complement(456174..457307) 1 NC_008611.1 cytoplasmic protein; domain homology - tRNA-dihydrouridine synthase [translation, ribosomal structure and biogenesis]; transcriptional regulator 457307 4549982 MUL_0444 Mycobacterium ulcerans Agy99 transcriptional regulator YP_904622.1 456174 R 362242 CDS YP_904623.1 118616291 4549983 complement(457316..458332) 1 NC_008611.1 cytoplasmic protein; involved in mycolic acid biosynthesis; acyl-[acyl-carrier protein] desaturase DesA1 458332 desA1 4549983 desA1 Mycobacterium ulcerans Agy99 acyl-[acyl-carrier protein] desaturase DesA1 YP_904623.1 457316 R 362242 CDS YP_904624.1 118616292 4549984 complement(458500..459141) 1 NC_008611.1 membrane protein; hypothetical protein 459141 4549984 MUL_0446 Mycobacterium ulcerans Agy99 hypothetical protein YP_904624.1 458500 R 362242 CDS YP_904625.1 118616293 4549985 459215..460273 1 NC_008611.1 cytoplasmic protein; hypothetical protein 460273 4549985 MUL_0447 Mycobacterium ulcerans Agy99 hypothetical protein YP_904625.1 459215 D 362242 CDS YP_904626.1 118616294 4549987 complement(460485..460856) 1 NC_008611.1 cytoplasmic protein; transcription regulator ArsR 460856 4549987 MUL_0448 Mycobacterium ulcerans Agy99 transcription regulator ArsR YP_904626.1 460485 R 362242 CDS YP_904627.1 118616295 4549988 complement(460914..461222) 1 NC_008611.1 cytoplasmic protein; function unknown, domain homology to CumB, cytosine/adenosine deaminases.; hypothetical protein 461222 4549988 MUL_0449 Mycobacterium ulcerans Agy99 hypothetical protein YP_904627.1 460914 R 362242 CDS YP_904628.1 118616296 4549989 461316..462221 1 NC_008611.1 membrane protein; function unknown, may be involved in polyketide biosynthesis [secondary metabolites biosynthesis, transport, and catabolism]; O-methyltransferase 462221 4549989 MUL_0450 Mycobacterium ulcerans Agy99 O-methyltransferase YP_904628.1 461316 D 362242 CDS YP_904629.1 118616297 4552776 463178..464224 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 464224 4552776 MUL_0452 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_904629.1 463178 D 362242 CDS YP_904630.1 118616298 4552777 complement(464190..465446) 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; domain: regulator of polyketide synthase expression; hypothetical protein 465446 4552777 MUL_0453 Mycobacterium ulcerans Agy99 hypothetical protein YP_904630.1 464190 R 362242 CDS YP_904631.1 118616299 4552778 465476..467974 1 NC_008611.1 membrane protein; thought to play an important role in the mineralization of sulfates [catalytic activity: a phenol sulfate + H2O = a phenol + sulfate]; arylsulfatase AtsD 467974 atsD 4552778 atsD Mycobacterium ulcerans Agy99 arylsulfatase AtsD YP_904631.1 465476 D 362242 CDS YP_904632.1 118616300 4552780 469958..470461 1 NC_008611.1 cytoplasmic protein; putative OHCU decarboxylase 470461 4552780 MUL_0456 Mycobacterium ulcerans Agy99 putative OHCU decarboxylase YP_904632.1 469958 D 362242 CDS YP_904633.1 118616301 4552781 470448..470819 1 NC_008611.1 cytoplasmic protein; domain homology: transthyretin, transthyretin precursor (formerly prealbumin) transthyretin is a thyroid hormone-binding protein that transports thyroxine from the bloodstream to the brain. mutations in the human transthyretin are associated with several genetic disorders; hypothetical protein 470819 4552781 MUL_0457 Mycobacterium ulcerans Agy99 hypothetical protein YP_904633.1 470448 D 362242 CDS YP_904634.1 118616302 4552782 470635..471642 1 NC_008611.1 membrane protein; domain: xanthine dehydrogenase, iron-sulfur cluster and FAD-binding subunit A [nucleotide transport and metabolism]; hypothetical protein 471642 4552782 MUL_0458 Mycobacterium ulcerans Agy99 hypothetical protein YP_904634.1 470635 D 362242 CDS YP_904635.1 118616303 4552783 471639..474341 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; carbon monoxide dehydrogenase 474341 4552783 MUL_0459 Mycobacterium ulcerans Agy99 carbon monoxide dehydrogenase YP_904635.1 471639 D 362242 CDS YP_904636.1 118616304 4552784 complement(474330..475259) 1 NC_008611.1 cytoplasmic protein; function unknown, contains a UbiH domain, 2- polyprenyl-6-methoxyphenol hydroxylase and related FAD- dependent oxidoreductases [coenzyme metabolism / energy production and conversion]; hypothetical protein 475259 4552784 MUL_0460 Mycobacterium ulcerans Agy99 hypothetical protein YP_904636.1 474330 R 362242 CDS YP_904637.1 118616305 4552786 complement(475563..476291) 1 NC_008611.1 Detected in the membrane fraction by proteomics.; membrane protein; hypothetical protein 476291 4552786 MUL_0462 Mycobacterium ulcerans Agy99 hypothetical protein YP_904637.1 475563 R 362242 CDS YP_904638.1 118616306 4552787 476453..477175 1 NC_008611.1 Detected in the membrane fraction by proteomics; membrane protein; involved in transcriptional mechanism. part of the two component regulatory system PhoP/PhoQ. this protein is thought to be a positive regulator for the phosphate regulon, required for intracellular growth. transcription of this operon is positively regulated by PhoB and PhoR when phosphate is limited; two component system response phosphate regulon transcriptional regulator, PhoP 477175 phoP 4552787 phoP Mycobacterium ulcerans Agy99 two component system response phosphate regulon transcriptional regulator, PhoP YP_904638.1 476453 D 362242 CDS YP_904639.1 118616307 4552788 477216..478661 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; sensor part of a two component regulatory system. this protein is thought to be a sensor kinase for the phosphate regulon. transcription of this operon is positively regulated by PhoB and PhoR when phosphate is limited; two component system response phosphate sensor kinase, PhoR 478661 phoR 4552788 phoR Mycobacterium ulcerans Agy99 two component system response phosphate sensor kinase, PhoR YP_904639.1 477216 D 362242 CDS YP_904640.1 118616308 4552789 complement(478668..479072) 1 NC_008611.1 Detected in the extracellular matrix by proteomics. Also detected in the cytoplasmic fraction by 2D-LC-MS/MS.; cytoplasmic protein; Hit family protein: diadenosine tetraphosphate (Ap4A) hydrolase and other Hit family hydrolases [nucleotide transport and metabolism / carbohydrate transport and metabolism / general function prediction only]; hypothetical protein 479072 4552789 MUL_0465 Mycobacterium ulcerans Agy99 hypothetical protein YP_904640.1 478668 R 362242 CDS YP_904641.1 118616309 4552791 480897..482339 1 NC_008611.1 secreted protein; hypothetical protein 482339 4552791 MUL_0467 Mycobacterium ulcerans Agy99 hypothetical protein YP_904641.1 480897 D 362242 CDS YP_904642.1 118616310 4552792 complement(482341..482760) 1 NC_008611.1 cytoplasmic protein; contains nuclear transport factor 2 (NTF2) domain; hypothetical protein 482760 4552792 MUL_0468 Mycobacterium ulcerans Agy99 hypothetical protein YP_904642.1 482341 R 362242 CDS YP_904643.1 118616311 4552793 complement(482763..483047) 1 NC_008611.1 cytoplasmic protein; function unknown, domain homology suggests possible NADH:flavin oxidoreductase; hypothetical protein 483047 4552793 MUL_0469 Mycobacterium ulcerans Agy99 hypothetical protein YP_904643.1 482763 R 362242 CDS YP_904644.1 118616312 4550676 complement(483077..484204) 1 NC_008611.1 membrane protein; thought to catalyze the reversible oxidation of ethanol to acetaldehyde with the concomitant reduction of NAD. probably acts on primary or secondary alcohols or hemiacetals [catalytic activity: an alcohol + NAD+ = an aldehyde or ketone + NADH]; zinc-containing alcohol dehydrogenase NAD- dependent AdhB 484204 adhB 4550676 adhB Mycobacterium ulcerans Agy99 zinc-containing alcohol dehydrogenase NAD- dependent AdhB YP_904644.1 483077 R 362242 CDS YP_904645.1 118616313 4550677 complement(484367..484912) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 484912 4550677 MUL_0471 Mycobacterium ulcerans Agy99 hypothetical protein YP_904645.1 484367 R 362242 CDS YP_904646.1 118616314 4550678 complement(484918..485124) 1 NC_008611.1 cytoplasmic protein; ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. probably involved in electron transport for cytochrome P- 450 system.; ferredoxin 485124 4550678 MUL_0472 Mycobacterium ulcerans Agy99 ferredoxin YP_904646.1 484918 R 362242 CDS YP_904647.1 118616315 4550679 complement(485124..486494) 1 NC_008611.1 cytoplasmic protein; involved in sterol biosynthesis. its biological substrate is not known. catalyzes C14-demethylation of lanosterol, 24,25-dihydrolanosterol and obtusifoliol which is critical for ergosterol biosynthesis. it transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3- beta-ol.; cytochrome P450 51B1 Cyp51B1 486494 cyp51B1 4550679 cyp51B1 Mycobacterium ulcerans Agy99 cytochrome P450 51B1 Cyp51B1 YP_904647.1 485124 R 362242 CDS YP_904648.1 118616316 4550680 complement(486491..487315) 1 NC_008611.1 membrane protein; function unknown, domain homology to short-chain dehydrogenase/reductase family; short chain dehydrogenase 487315 4550680 MUL_0474 Mycobacterium ulcerans Agy99 short chain dehydrogenase YP_904648.1 486491 R 362242 CDS YP_904649.1 118616317 4550681 complement(487315..488535) 1 NC_008611.1 cytoplasmic protein; cytochrome P450s are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics; cytochrome P450 123A3 Cyp123A3 488535 cyp123A3 4550681 cyp123A3 Mycobacterium ulcerans Agy99 cytochrome P450 123A3 Cyp123A3 YP_904649.1 487315 R 362242 CDS YP_904650.1 118616318 4550682 complement(488532..488951) 1 NC_008611.1 membrane protein; hypothetical protein 488951 4550682 MUL_0476 Mycobacterium ulcerans Agy99 hypothetical protein YP_904650.1 488532 R 362242 CDS YP_904651.1 118616319 4550683 489411..490880 1 NC_008611.1 cytoplasmic protein; oxidizes a variety of aldehydes [catalytic activity: an aldehyde + NAD+ + H2O = an acid + NADH]; NAD-dependent aldehyde dehydrogenase, AldA 490880 aldA 4550683 aldA Mycobacterium ulcerans Agy99 NAD-dependent aldehyde dehydrogenase, AldA YP_904651.1 489411 D 362242 CDS YP_904652.1 118616320 4550684 490891..491643 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; membrane protein; short chain dehydrogenase 491643 4550684 MUL_0478 Mycobacterium ulcerans Agy99 short chain dehydrogenase YP_904652.1 490891 D 362242 CDS YP_904653.1 118616321 4550686 492554..492991 1 NC_008611.1 cytoplasmic protein; involved in aromatic hydrocarbons catabolism. thought to be involved in the catabolism of protocatechuate to succinate-and acetyl-CoA in the beta- ketoadipate pathway (at the third step) [catalytic activity: 2-carboxy-5-oxo-2,5-dihydrofuran-2-acetate = 5- oxo-4,5-dihydrofuran-2-acetate + CO(2)]; 4-carboxymuconolactone decarboxylase 492991 4550686 MUL_0480 Mycobacterium ulcerans Agy99 4-carboxymuconolactone decarboxylase YP_904653.1 492554 D 362242 CDS YP_904654.1 118616322 4550687 493030..494298 1 NC_008611.1 catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis; phosphoribosylamine--glycine ligase 494298 purD 4550687 purD Mycobacterium ulcerans Agy99 phosphoribosylamine--glycine ligase YP_904654.1 493030 D 362242 CDS YP_904655.1 118616323 4550688 complement(494338..495840) 1 NC_008611.1 membrane protein; involved in signal transduction (via phosphorylation) [catalytic activity: ATP + a protein = ADP + a phosphoprotein]; serine/threonine-protein kinase PknF_2 495840 pknF_2 4550688 pknF_2 Mycobacterium ulcerans Agy99 serine/threonine-protein kinase PknF_2 YP_904655.1 494338 R 362242 CDS YP_904656.1 118616324 4550689 496226..497140 1 NC_008611.1 cytoplasmic protein; domain: UspA, universal stress protein UspA and related nucleotide-binding proteins [signal transduction mechanisms]; hypothetical protein 497140 4550689 MUL_0483 Mycobacterium ulcerans Agy99 hypothetical protein YP_904656.1 496226 D 362242 CDS YP_904657.1 118616325 4550690 complement(497169..499463) 1 NC_008611.1 membrane protein; involved in biosynthesis of a demolybdo cofactor (molybdopterin), necessary for molybdoenzymes. plays a role in the activation of the small subunit of the molybdopterin converting factor (MoaD); hypothetical protein 499463 moeY 4550690 moeY Mycobacterium ulcerans Agy99 hypothetical protein YP_904657.1 497169 R 362242 CDS YP_904658.1 118616326 4550691 499537..500583 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 500583 4550691 MUL_0485 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_904658.1 499537 D 362242 CDS YP_904659.1 118616327 4550692 complement(501119..502528) 1 NC_008611.1 cytoplasmic protein; besides the cephalosporin acylase I activity which converts GL-7ACA into 7-Aca; this enzyme displays some gamma glutamyltranspeptidase activity: Ggt plays a key role in the gamma-glutamyl cycle, a pathway for the synthesis and degradation of glutathione. [catalytic activity 1: 7-beta-(4-carboxybutanamido)-cephalosporanic acid + H2O = 7-aminocephalosporanic acid + glutaric acid] [catalytic activity 2: (5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl-amino acid]; bifunctional acylase, GgtA 502528 ggtA 4550692 ggtA Mycobacterium ulcerans Agy99 bifunctional acylase, GgtA YP_904659.1 501119 R 362242 CDS YP_904660.1 118616328 4551981 complement(502580..503518) 1 NC_008611.1 membrane protein; function unknown, contains esterase domain; hypothetical protein 503518 4551981 MUL_0487 Mycobacterium ulcerans Agy99 hypothetical protein YP_904660.1 502580 R 362242 CDS YP_904661.1 118616329 4551982 503553..504122 1 NC_008611.1 membrane protein; contains transcriptional regulatory domain; hypothetical protein 504122 4551982 MUL_0488 Mycobacterium ulcerans Agy99 hypothetical protein YP_904661.1 503553 D 362242 CDS YP_904662.1 118616330 4551983 complement(504163..504924) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 504924 4551983 MUL_0489 Mycobacterium ulcerans Agy99 hypothetical protein YP_904662.1 504163 R 362242 CDS YP_904663.1 118616331 4551984 505043..506470 1 NC_008611.1 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide; adenylosuccinate lyase 506470 purB 4551984 purB Mycobacterium ulcerans Agy99 adenylosuccinate lyase YP_904663.1 505043 D 362242 CDS YP_904664.1 118616332 4551985 506467..507723 1 NC_008611.1 cytoplasmic protein; cytochromes P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.; cytochrome P450 126A3 Cyp126A3 507723 cyp126A3 4551985 cyp126A3 Mycobacterium ulcerans Agy99 cytochrome P450 126A3 Cyp126A3 YP_904664.1 506467 D 362242 CDS YP_904665.1 118616333 4551986 508010..509218 1 NC_008611.1 membrane protein; PPE family protein 509218 4551986 MUL_0492 Mycobacterium ulcerans Agy99 PPE family protein YP_904665.1 508010 D 362242 CDS YP_904666.1 118616334 4551987 509422..510711 1 NC_008611.1 cytoplasmic protein; possibly involed in transcription regulation; DNA- binding.; putative regulatory protein 510711 4551987 MUL_0493 Mycobacterium ulcerans Agy99 putative regulatory protein YP_904666.1 509422 D 362242 CDS YP_904667.1 118616335 4551988 510843..512366 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS. Also detected in the membrane fraction by proteomics (LC-MS/MS); cytoplasmic protein; interconversion aldehyde and acid [catalytic activity: an aldehyde + NAD+ + H2O = an acid + NADH]; aldehyde dehydrogenase 512366 4551988 MUL_0494 Mycobacterium ulcerans Agy99 aldehyde dehydrogenase YP_904667.1 510843 D 362242 CDS YP_904668.1 118616336 4551989 512418..513479 1 NC_008611.1 cytoplasmic protein; Zn-dependent alcohol dehydrogenase, AdhX 513479 adhX 4551989 adhX Mycobacterium ulcerans Agy99 Zn-dependent alcohol dehydrogenase, AdhX YP_904668.1 512418 D 362242 CDS YP_904669.1 118616337 4551990 complement(513470..514090) 1 NC_008611.1 membrane protein; transmembrane protein 514090 4551990 MUL_0496 Mycobacterium ulcerans Agy99 transmembrane protein YP_904669.1 513470 R 362242 CDS YP_904670.1 118616338 4551991 514155..515048 1 NC_008611.1 catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase; phosphoribosylaminoimidazole-succinocarboxamide synthase 515048 purC 4551991 purC Mycobacterium ulcerans Agy99 phosphoribosylaminoimidazole-succinocarboxamide synthase YP_904670.1 514155 D 362242 CDS YP_904671.1 118616339 4551992 515027..517162 1 NC_008611.1 cytoplasmic protein; cleaves peptide bonds on the C-terminal side of LysYL and argininyl residues [catalytic activity: hydrolysis of arg-|-xaa and lys-|-xaa bonds in oligopeptides, even when P1' residue is proline]; protease II (oligopeptidase B), PtrB 517162 ptrB 4551992 ptrB Mycobacterium ulcerans Agy99 protease II (oligopeptidase B), PtrB YP_904671.1 515027 D 362242 CDS YP_904672.1 118616340 4551993 complement(517121..517570) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; hypothetical protein 517570 4551993 MUL_0499 Mycobacterium ulcerans Agy99 hypothetical protein YP_904672.1 517121 R 362242 CDS YP_904673.1 118616341 4551994 517665..518381 1 NC_008611.1 cytoplasmic protein; TetR-family; transcriptional regulator 518381 4551994 MUL_0500 Mycobacterium ulcerans Agy99 transcriptional regulator YP_904673.1 517665 D 362242 CDS YP_904674.1 118616342 4551995 complement(518175..519836) 1 NC_008611.1 membrane protein; translocase that confers resistance to substances of high hydrophobicity. involved in transport of multidrug across the membrane (export): multidrug resistance by an export mechanism. responsible for the translocation of the substrate across the membrane.; integral membrane drug efflux protein 519836 4551995 MUL_0501 Mycobacterium ulcerans Agy99 integral membrane drug efflux protein YP_904674.1 518175 R 362242 CDS YP_904675.1 118616343 4551996 520005..520709 1 NC_008611.1 cytoplasmic protein; hypothetical protein 520709 4551996 MUL_0502 Mycobacterium ulcerans Agy99 hypothetical protein YP_904675.1 520005 D 362242 CDS YP_904676.1 118616344 4551997 complement(520667..521713) 1 NC_008611.1 membrane protein; hypothetical protein 521713 4551997 MUL_0503 Mycobacterium ulcerans Agy99 hypothetical protein YP_904676.1 520667 R 362242 CDS YP_904677.1 118616345 4551998 complement(521765..521959) 1 NC_008611.1 hypothetical protein 521959 4551998 MUL_0504 Mycobacterium ulcerans Agy99 hypothetical protein YP_904677.1 521765 R 362242 CDS YP_904678.1 118616346 4551999 complement(521934..522296) 1 NC_008611.1 secreted protein; hypothetical protein 522296 4551999 MUL_0505 Mycobacterium ulcerans Agy99 hypothetical protein YP_904678.1 521934 R 362242 CDS YP_904679.1 118616347 4550747 522629..522979 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; N-term transposase for IS2404 522979 4550747 MUL_0506 Mycobacterium ulcerans Agy99 N-term transposase for IS2404 YP_904679.1 522629 D 362242 CDS YP_904680.1 118616348 4550748 523049..523675 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; C-term transposase for IS2404 523675 4550748 MUL_0507 Mycobacterium ulcerans Agy99 C-term transposase for IS2404 YP_904680.1 523049 D 362242 CDS YP_904681.1 118616349 4550749 523885..524253 1 NC_008611.1 cytoplasmic protein; hypothetical protein 524253 4550749 MUL_0508 Mycobacterium ulcerans Agy99 hypothetical protein YP_904681.1 523885 D 362242 CDS YP_904682.1 118616350 4550750 524368..524871 1 NC_008611.1 cytoplasmic protein; excisionase 524871 4550750 MUL_0509 Mycobacterium ulcerans Agy99 excisionase YP_904682.1 524368 D 362242 CDS YP_904683.1 118616351 4550751 524902..525072 1 NC_008611.1 cytoplasmic protein; hypothetical protein 525072 4550751 MUL_0510 Mycobacterium ulcerans Agy99 hypothetical protein YP_904683.1 524902 D 362242 CDS YP_904684.1 118616352 4550752 525269..525502 1 NC_008611.1 cytoplasmic protein; hypothetical protein 525502 4550752 MUL_0511 Mycobacterium ulcerans Agy99 hypothetical protein YP_904684.1 525269 D 362242 CDS YP_904685.1 118616353 4550753 525804..527240 1 NC_008611.1 cytoplasmic protein; hypothetical protein 527240 4550753 MUL_0512 Mycobacterium ulcerans Agy99 hypothetical protein YP_904685.1 525804 D 362242 CDS YP_904686.1 118616354 4550754 complement(527247..528020) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 528020 4550754 MUL_0513 Mycobacterium ulcerans Agy99 hypothetical protein YP_904686.1 527247 R 362242 CDS YP_904687.1 118616355 4550756 528829..530424 1 NC_008611.1 cytoplasmic protein; hypothetical protein 530424 4550756 MUL_0515 Mycobacterium ulcerans Agy99 hypothetical protein YP_904687.1 528829 D 362242 CDS YP_904688.1 118616356 4550757 530613..531470 1 NC_008611.1 cytoplasmic protein; hypothetical protein 531470 4550757 MUL_0516 Mycobacterium ulcerans Agy99 hypothetical protein YP_904688.1 530613 D 362242 CDS YP_904689.1 118616357 4550758 531483..531635 1 NC_008611.1 cytoplasmic protein; hypothetical protein 531635 4550758 MUL_0517 Mycobacterium ulcerans Agy99 hypothetical protein YP_904689.1 531483 D 362242 CDS YP_904690.1 118616358 4550759 531637..532416 1 NC_008611.1 membrane protein; frameshift mutant?; hypothetical protein 532416 4550759 MUL_0518 Mycobacterium ulcerans Agy99 hypothetical protein YP_904690.1 531637 D 362242 CDS YP_904691.1 118616359 4550761 533642..534985 1 NC_008611.1 cytoplasmic protein; required for the transposition of the insertion element IS2606.; transposase for IS2606 534985 4550761 MUL_0520 Mycobacterium ulcerans Agy99 transposase for IS2606 YP_904691.1 533642 D 362242 CDS YP_904692.1 118616360 4552236 535354..536400 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 536400 4552236 MUL_0521 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_904692.1 535354 D 362242 CDS YP_904693.1 118616361 4552238 537317..537520 1 NC_008611.1 cytoplasmic protein; hypothetical protein 537520 4552238 MUL_0523 Mycobacterium ulcerans Agy99 hypothetical protein YP_904693.1 537317 D 362242 CDS YP_904694.1 118616362 4552239 complement(537534..537968) 1 NC_008611.1 cytoplasmic protein; may be an ADP-ribose pyrophosphatase - involved DNA replication, recombination, and repair; hypothetical protein 537968 4552239 MUL_0524 Mycobacterium ulcerans Agy99 hypothetical protein YP_904694.1 537534 R 362242 CDS YP_904695.1 118616363 4552240 538041..538835 1 NC_008611.1 GntR-family transcriptional regulator; Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; transcriptional regulatory protein 538835 4552240 MUL_0525 Mycobacterium ulcerans Agy99 transcriptional regulatory protein YP_904695.1 538041 D 362242 CDS YP_904696.1 118616364 4552241 538935..539357 1 NC_008611.1 cytoplasmic protein; hypothetical protein 539357 4552241 MUL_0526 Mycobacterium ulcerans Agy99 hypothetical protein YP_904696.1 538935 D 362242 CDS YP_904697.1 118616365 4552242 539414..540676 1 NC_008611.1 membrane protein; contains FtsK domain: FtsK has extensive sequence similarity to wide variety of proteins from prokaryotes and plasmids, termed the FtsK/SpoIIIE family. this domain contains a putative ATP binding P-loop motif. it is found in the FtsK cell division protein from E. coli and the stage III sporulation protein E SpoIIIE, which has roles in regulation of prespore specific gene expression in B. subtilis. a mutation in FtsK causes a temperature sensitive block in cell division and it is involved in peptidoglycan synthesis or modification. the SpoIIIE protein is implicated in intercellular chromosomal DNA transfer.; hypothetical protein 540676 4552242 MUL_0527 Mycobacterium ulcerans Agy99 hypothetical protein YP_904697.1 539414 D 362242 CDS YP_904698.1 118616366 4552243 540685..540948 1 NC_008611.1 cytoplasmic protein; hypothetical protein 540948 4552243 MUL_0528 Mycobacterium ulcerans Agy99 hypothetical protein YP_904698.1 540685 D 362242 CDS YP_904699.1 118616367 4552244 540948..542117 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS; cytoplasmic protein; part of a prophage not present in M. marinum; prophage integrase 542117 4552244 MUL_0529 Mycobacterium ulcerans Agy99 prophage integrase YP_904699.1 540948 D 362242 CDS YP_904700.1 118616368 4549991 complement(543034..544080) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 544080 4549991 MUL_0535 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_904700.1 543034 R 362242 CDS YP_904701.1 118616369 4549992 complement(544542..545348) 1 NC_008611.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 545348 echA8_3 4549992 echA8_3 Mycobacterium ulcerans Agy99 enoyl-CoA hydratase YP_904701.1 544542 R 362242 CDS YP_904702.1 118616370 4549994 546180..547226 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 547226 4549994 MUL_0538 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_904702.1 546180 D 362242 CDS YP_904703.1 118616371 4549995 548714..550207 1 NC_008611.1 Detected in the membrane fraction by proteomics (2D- LC-MS/MS); membrane protein; hydrolyzes a monocarboxylic acid amide and generates a monocarboxylate [catalytic activity: a monocarboxylic acid amide + H(2)O = a monocarboxylate + NH(3)]; amidase, AmiC_2 550207 amiC_2 4549995 amiC_2 Mycobacterium ulcerans Agy99 amidase, AmiC_2 YP_904703.1 548714 D 362242 CDS YP_904704.1 118616372 4549997 552061..553314 1 NC_008611.1 membrane protein; function unknown, facilitates transport of small solutes in or out of the cell.; multidrug resistance integral membrane efflux protein 553314 4549997 MUL_0542 Mycobacterium ulcerans Agy99 multidrug resistance integral membrane efflux protein YP_904704.1 552061 D 362242 CDS YP_904705.1 118616373 4549999 553832..554593 1 NC_008611.1 membrane protein; dehydrogenase 554593 4549999 MUL_0544 Mycobacterium ulcerans Agy99 dehydrogenase YP_904705.1 553832 D 362242 CDS YP_904706.1 118616374 4550000 554604..555272 1 NC_008611.1 cytoplasmic protein; hydrolase 555272 4550000 MUL_0545 Mycobacterium ulcerans Agy99 hydrolase YP_904706.1 554604 D 362242 CDS YP_904707.1 118616375 4550001 555279..556121 1 NC_008611.1 membrane protein; domain homology to NagC, transcriptional regulator/sugar kinase [transcription / carbohydrate transport and metabolism]; glucose kinase 556121 4550001 MUL_0546 Mycobacterium ulcerans Agy99 glucose kinase YP_904707.1 555279 D 362242 CDS YP_904708.1 118616376 4550003 557383..558168 1 NC_008611.1 membrane protein; epimerase 558168 4550003 MUL_0548 Mycobacterium ulcerans Agy99 epimerase YP_904708.1 557383 D 362242 CDS YP_904709.1 118616377 4550004 558273..559166 1 NC_008611.1 cytoplasmic protein; hypothetical protein 559166 4550004 MUL_0549 Mycobacterium ulcerans Agy99 hypothetical protein YP_904709.1 558273 D 362242 CDS YP_904710.1 118616378 4550005 complement(559251..559460) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 559460 4550005 MUL_5123 Mycobacterium ulcerans Agy99 hypothetical protein YP_904710.1 559251 R 362242 CDS YP_904711.1 118616379 4550693 559999..561045 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 561045 4550693 MUL_0550 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_904711.1 559999 D 362242 CDS YP_904712.1 118616380 4550694 complement(561042..561290) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 561290 4550694 MUL_0551 Mycobacterium ulcerans Agy99 hypothetical protein YP_904712.1 561042 R 362242 CDS YP_904713.1 118616381 4550695 complement(561291..561713) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 561713 4550695 MUL_0552 Mycobacterium ulcerans Agy99 hypothetical protein YP_904713.1 561291 R 362242 CDS YP_904714.1 118616382 4550697 complement(562014..562793) 1 NC_008611.1 membrane protein; involved in transcriptional mechanism.; transcriptional regulatory protein 562793 4550697 MUL_0554 Mycobacterium ulcerans Agy99 transcriptional regulatory protein YP_904714.1 562014 R 362242 CDS YP_904715.1 118616383 4550699 564418..564798 1 NC_008611.1 cytoplasmic protein; hypothetical protein 564798 4550699 MUL_0556 Mycobacterium ulcerans Agy99 hypothetical protein YP_904715.1 564418 D 362242 CDS YP_904716.1 118616384 4550701 565709..566377 1 NC_008611.1 secreted protein; maybe exported; hypothetical protein 566377 4550701 MUL_0559 Mycobacterium ulcerans Agy99 hypothetical protein YP_904716.1 565709 D 362242 CDS YP_904717.1 118616385 4550702 566423..566995 1 NC_008611.1 Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis; deoxycytidine triphosphate deaminase 566995 dcd 4550702 dcd Mycobacterium ulcerans Agy99 deoxycytidine triphosphate deaminase YP_904717.1 566423 D 362242 CDS YP_904718.1 118616386 4550704 complement(568350..568718) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 568718 4550704 MUL_0562 Mycobacterium ulcerans Agy99 hypothetical protein YP_904718.1 568350 R 362242 CDS YP_904719.1 118616387 4550707 571803..572558 1 NC_008611.1 cytoplasmic protein; hypothetical protein 572558 4550707 MUL_0566 Mycobacterium ulcerans Agy99 hypothetical protein YP_904719.1 571803 D 362242 CDS YP_904720.1 118616388 4550708 572585..572968 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; hypothetical protein 572968 4550708 MUL_0567 Mycobacterium ulcerans Agy99 hypothetical protein YP_904720.1 572585 D 362242 CDS YP_904721.1 118616389 4552727 572998..573864 1 NC_008611.1 cytoplasmic protein; dTDP-L-rhamnose biosynthesis within the O antigen biosynthesis pathway of lipopolysaccharide biosynthesis [catalytic activity: dTTP + alpha-D-glucose 1-phosphate = diphosphate + dTDP-glucose]; alpha-D-glucose-1-phosphate thymidylyl- transferase, RmlA 573864 rmlA 4552727 rmlA Mycobacterium ulcerans Agy99 alpha-D-glucose-1-phosphate thymidylyl- transferase, RmlA YP_904721.1 572998 D 362242 CDS YP_904722.1 118616390 4552728 complement(573898..574929) 1 NC_008611.1 membrane protein; function unknown. seems to influence both cell surface interactions among mycobacteria and the interactions of the bacteria with macrophages.; PE_PGRS family protein 574929 4552728 MUL_0569 Mycobacterium ulcerans Agy99 PE_PGRS family protein YP_904722.1 573898 R 362242 CDS YP_904723.1 118616391 4552729 complement(575111..576157) 1 NC_008611.1 membrane protein; PE_PGRS family protein 576157 4552729 MUL_0570 Mycobacterium ulcerans Agy99 PE_PGRS family protein YP_904723.1 575111 R 362242 CDS YP_904724.1 118616392 4552730 complement(576289..577182) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; C-term transposase for IS2404 577182 4552730 MUL_0571 Mycobacterium ulcerans Agy99 C-term transposase for IS2404 YP_904724.1 576289 R 362242 CDS YP_904725.1 118616393 4552731 577925..580594 1 NC_008611.1 membrane protein; function unknown, member of the mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins; PE-PGRS family protein 580594 4552731 MUL_0572 Mycobacterium ulcerans Agy99 PE-PGRS family protein YP_904725.1 577925 D 362242 CDS YP_904726.1 118616394 4552732 complement(580688..581977) 1 NC_008611.1 broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor; aminotransferase AlaT 581977 aspC 4552732 aspC Mycobacterium ulcerans Agy99 aminotransferase AlaT YP_904726.1 580688 R 362242 CDS YP_904727.1 118616395 4552733 complement(582008..584956) 1 NC_008611.1 Detected in the membrane fraction by proteomics (2D- LC-MS/MS); membrane protein; iron-sulphur-binding reductase 584956 4552733 MUL_0574 Mycobacterium ulcerans Agy99 iron-sulphur-binding reductase YP_904727.1 582008 R 362242 CDS YP_904728.1 118616396 4552734 complement(585218..586561) 1 NC_008611.1 cytoplasmic protein; required for the transposition of the insertion element IS2606.; transposase for IS2606 586561 4552734 MUL_0575 Mycobacterium ulcerans Agy99 transposase for IS2606 YP_904728.1 585218 R 362242 CDS YP_904729.1 118616397 4552735 587077..587970 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; C-term transposase for IS2404 587970 4552735 MUL_0576 Mycobacterium ulcerans Agy99 C-term transposase for IS2404 YP_904729.1 587077 D 362242 CDS YP_904730.1 118616398 4552737 590363..590902 1 NC_008611.1 cytoplasmic protein; hypothetical protein 590902 4552737 MUL_0578 Mycobacterium ulcerans Agy99 hypothetical protein YP_904730.1 590363 D 362242 CDS YP_904731.1 118616399 4552738 591184..594051 1 NC_008611.1 membrane protein; function unknown function but ortholog in M.tuberculosis induced by isoniazid and ethionamide.; membrane protein, IniB 594051 iniB 4552738 iniB Mycobacterium ulcerans Agy99 membrane protein, IniB YP_904731.1 591184 D 362242 CDS YP_904732.1 118616400 4552739 594152..595993 1 NC_008611.1 membrane protein; in M. tuberculosis H37Rv this gene is induced by isoniazid (INH) or ethionamide treatment) (see Wilson et al., 1999); hypothetical protein 595993 iniA 4552739 iniA Mycobacterium ulcerans Agy99 hypothetical protein YP_904732.1 594152 D 362242 CDS YP_904733.1 118616401 4552740 595990..597471 1 NC_008611.1 membrane protein; in M. tuberculosis H37Rv IniC is an isoniazid- inducible gene; protein IniC 597471 iniC 4552740 iniC Mycobacterium ulcerans Agy99 protein IniC YP_904733.1 595990 D 362242 CDS YP_904734.1 118616402 4552741 complement(597476..599296) 1 NC_008611.1 membrane protein; hypothetical protein 599296 4552741 MUL_0582 Mycobacterium ulcerans Agy99 hypothetical protein YP_904734.1 597476 R 362242 CDS YP_904735.1 118616403 4553498 complement(599379..599903) 1 NC_008611.1 membrane protein; hypothetical protein 599903 4553498 MUL_0583 Mycobacterium ulcerans Agy99 hypothetical protein YP_904735.1 599379 R 362242 CDS YP_904736.1 118616404 4553499 complement(600011..600592) 1 NC_008611.1 membrane protein; hypothetical protein 600592 4553499 MUL_0584 Mycobacterium ulcerans Agy99 hypothetical protein YP_904736.1 600011 R 362242 CDS YP_904737.1 118616405 4553500 complement(600629..601192) 1 NC_008611.1 membrane protein; lipoprotein, LpqJ 601192 lpqJ 4553500 lpqJ Mycobacterium ulcerans Agy99 lipoprotein, LpqJ YP_904737.1 600629 R 362242 CDS YP_904738.1 118616406 4553502 complement(601753..602640) 1 NC_008611.1 cytoplasmic protein; aerobic-type carbon monoxide dehydrogenase, CoxM_2 602640 coxM_2 4553502 coxM_2 Mycobacterium ulcerans Agy99 aerobic-type carbon monoxide dehydrogenase, CoxM_2 YP_904738.1 601753 R 362242 CDS YP_904739.1 118616407 4553503 complement(602637..604967) 1 NC_008611.1 cytoplasmic protein; aerobic-type carbon monoxide dehydrogenase, CoxL_2 604967 coxL_2 4553503 coxL_2 Mycobacterium ulcerans Agy99 aerobic-type carbon monoxide dehydrogenase, CoxL_2 YP_904739.1 602637 R 362242 CDS YP_904740.1 118616408 4553504 605118..605648 1 NC_008611.1 membrane protein; hypothetical protein 605648 4553504 MUL_0589 Mycobacterium ulcerans Agy99 hypothetical protein YP_904740.1 605118 D 362242 CDS YP_904741.1 118616409 4553507 608083..609951 1 NC_008611.1 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria; molecular chaperone DnaK 609951 dnaK 4553507 dnaK Mycobacterium ulcerans Agy99 molecular chaperone DnaK YP_904741.1 608083 D 362242 CDS YP_904742.1 118616410 4553508 609948..610601 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS. Also detected in the extracellular matrix by proteomics.; cytoplasmic protein; stimulates, jointly with DnaJ, the ATPase activity of DnaK. helps to release ADP from DnaK thus allowing DnaK to recycle more efficiently. seems to be regulated negatively by HspR.; GrpE protein (Hsp-70 cofactor) 610601 grpE 4553508 grpE Mycobacterium ulcerans Agy99 GrpE protein (Hsp-70 cofactor) YP_904742.1 609948 D 362242 CDS YP_904743.1 118616411 4553509 610659..611849 1 NC_008611.1 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion; chaperone protein DnaJ 611849 dnaJ 4553509 dnaJ Mycobacterium ulcerans Agy99 chaperone protein DnaJ YP_904743.1 610659 D 362242 CDS YP_904744.1 118616412 4553510 611850..612332 1 NC_008611.1 Extended C-term caused by point mutation removing stop codon. This CDS now overlap the C-term of the d/s CDS.; cytoplasmic protein; involved in transcriptional regulation (repression) of heat shock proteins e.g. DnaK, GrpE, DnaJ. binds to three inverted repeats (IR1-IR3) in the promoter region of the DnaK operon. induction: by heat shock.; heat shock protein transcriptional repressor HspR 612332 hspR 4553510 hspR Mycobacterium ulcerans Agy99 heat shock protein transcriptional repressor HspR YP_904744.1 611850 D 362242 CDS YP_904745.1 118616413 4553512 616018..617352 1 NC_008611.1 cytoplasmic protein; required for the transposition of the insertion element IS2606.; transposase for IS2606 617352 4553512 MUL_0598 Mycobacterium ulcerans Agy99 transposase for IS2606 YP_904745.1 616018 D 362242 CDS YP_904746.1 118616414 4550762 complement(619158..620489) 1 NC_008611.1 cytoplasmic protein; required for the transposition of the insertion element IS2606.; transposase for IS2606 620489 4550762 MUL_0601 Mycobacterium ulcerans Agy99 transposase for IS2606 YP_904746.1 619158 R 362242 CDS YP_904747.1 118616415 4550763 complement(622440..623855) 1 NC_008611.1 cytoplasmic protein; cytochromes P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. some have been shown to bind tightly to a range of azole-based antifungal drugs (E.G. miconazole, clotrimazole); cytochrome P450 185A4 Cyp185A4 623855 cyp185A4 4550763 cyp185A4 Mycobacterium ulcerans Agy99 cytochrome P450 185A4 Cyp185A4 YP_904747.1 622440 R 362242 CDS YP_904748.1 118616416 4550764 complement(624817..625266) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 625266 4550764 MUL_0605 Mycobacterium ulcerans Agy99 hypothetical protein YP_904748.1 624817 R 362242 CDS YP_904749.1 118616417 4550765 625492..626829 1 NC_008611.1 membrane protein; membrane acyltransferase 626829 4550765 MUL_0606 Mycobacterium ulcerans Agy99 membrane acyltransferase YP_904749.1 625492 D 362242 CDS YP_904750.1 118616418 4550766 626914..627666 1 NC_008611.1 secreted protein; function unknown, domain identity to secreted hydrolases of the SgnH_hydrolase subfamily; hypothetical protein 627666 4550766 MUL_0607 Mycobacterium ulcerans Agy99 hypothetical protein YP_904750.1 626914 D 362242 CDS YP_904751.1 118616419 4550767 complement(627736..627852) 1 NC_008611.1 membrane protein; hypothetical protein 627852 4550767 MUL_0608 Mycobacterium ulcerans Agy99 hypothetical protein YP_904751.1 627736 R 362242 CDS YP_904752.1 118616420 4550768 complement(627964..630009) 1 NC_008611.1 membrane protein; transmembrane acyltransferase 630009 4550768 MUL_0609 Mycobacterium ulcerans Agy99 transmembrane acyltransferase YP_904752.1 627964 R 362242 CDS YP_904753.1 118616421 4550769 complement(630176..631084) 1 NC_008611.1 membrane protein; has homology to a putative esterase domain; hypothetical protein 631084 4550769 MUL_0610 Mycobacterium ulcerans Agy99 hypothetical protein YP_904753.1 630176 R 362242 CDS YP_904754.1 118616422 4550770 631231..632223 1 NC_008611.1 cytoplasmic protein; some similarity to universal stress protein UspA.; hypothetical protein 632223 4550770 MUL_0611 Mycobacterium ulcerans Agy99 hypothetical protein YP_904754.1 631231 D 362242 CDS YP_904755.1 118616423 4550771 632275..634992 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; metal cation-transporting ATPase; possibly catalyzes the transport of a undeterminated metal cation with the hydrolyse of ATP [catalytic activity: ATP + H(2)O + undetermined metal cation(in) = ADP + phosphate + undetermined metal cation(out); metal cation-transporting p-type ATPase F, CtpF 634992 ctpF 4550771 ctpF Mycobacterium ulcerans Agy99 metal cation-transporting p-type ATPase F, CtpF YP_904755.1 632275 D 362242 CDS YP_904756.1 118616424 4550773 complement(636161..637207) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 637207 4550773 MUL_0614 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_904756.1 636161 R 362242 CDS YP_904757.1 118616425 4550775 complement(639830..640747) 1 NC_008611.1 membrane protein; ketopantoate reductase PanE/ApbA. this is a family of 2-dehydropantoate 2-reductases also known as ketopantoate reductases. the reaction catalysed by this enzyme is: (R)-pantoate + NADP(+) <=> 2-dehydropantoate + NADPH. AbpA catalyses the NADPH reduction of ketopantoic acid to pantoic acid in the alternative pyrimidine biosynthetic (APB) pathway. ApbA and pane are allelic. ApbA, the ketopantoate reductase enzyme is required for the synthesis of thiamine via the APB biosynthetic pathway.; ketopantoate reductase, ApbA 640747 apbA 4550775 apbA Mycobacterium ulcerans Agy99 ketopantoate reductase, ApbA YP_904757.1 639830 R 362242 CDS YP_904758.1 118616426 4550777 642133..642480 1 NC_008611.1 cytoplasmic protein; hypothetical protein 642480 4550777 MUL_0619 Mycobacterium ulcerans Agy99 hypothetical protein YP_904758.1 642133 D 362242 CDS YP_904759.1 118616427 4550778 complement(642477..642776) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 642776 4550778 MUL_0620 Mycobacterium ulcerans Agy99 hypothetical protein YP_904759.1 642477 R 362242 CDS YP_904760.1 118616428 4551620 645805..647136 1 NC_008611.1 Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway; glutamate-1-semialdehyde aminotransferase 647136 hemL 4551620 hemL Mycobacterium ulcerans Agy99 glutamate-1-semialdehyde aminotransferase YP_904760.1 645805 D 362242 CDS YP_904761.1 118616429 4551621 647136..647744 1 NC_008611.1 cytoplasmic protein; contains fructose-2,6-bisphosphatase domain [carbohydrate transport and metabolism]; hypothetical protein 647744 4551621 MUL_0624 Mycobacterium ulcerans Agy99 hypothetical protein YP_904761.1 647136 D 362242 CDS YP_904762.1 118616430 4551622 647741..648358 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; thioredoxin protein (thiol-disulfide interchange protein) 648358 4551622 MUL_0625 Mycobacterium ulcerans Agy99 thioredoxin protein (thiol-disulfide interchange protein) YP_904762.1 647741 D 362242 CDS YP_904763.1 118616431 4551623 648355..649146 1 NC_008611.1 membrane protein; required during cytochrome biogenesis at the step of HemE attachment.; cytochrome C-type biogenesis protein, CcsA 649146 ccsA 4551623 ccsA Mycobacterium ulcerans Agy99 cytochrome C-type biogenesis protein, CcsA YP_904763.1 648355 D 362242 CDS YP_904764.1 118616432 4551624 649143..650822 1 NC_008611.1 membrane protein; required for cytochrome C biosynthesis; ResB-family protein 650822 4551624 MUL_0627 Mycobacterium ulcerans Agy99 ResB-family protein YP_904764.1 649143 D 362242 CDS YP_904765.1 118616433 4551625 650819..651805 1 NC_008611.1 membrane protein; required during cytochrome biogenesis at the step of HemE attachment.; cytochrome C-type biogenesis protein, CcsB 651805 ccsB 4551625 ccsB Mycobacterium ulcerans Agy99 cytochrome C-type biogenesis protein, CcsB YP_904765.1 650819 D 362242 CDS YP_904766.1 118616434 4551627 complement(653170..653322) 1 NC_008611.1 membrane protein; hypothetical protein 653322 4551627 MUL_0630 Mycobacterium ulcerans Agy99 hypothetical protein YP_904766.1 653170 R 362242 CDS YP_904767.1 118616435 4551628 653369..653737 1 NC_008611.1 membrane protein; hypothetical protein 653737 4551628 MUL_0631 Mycobacterium ulcerans Agy99 hypothetical protein YP_904767.1 653369 D 362242 CDS YP_904768.1 118616436 4551629 complement(653745..654752) 1 NC_008611.1 FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs; 3-oxoacyl-(acyl carrier protein) synthase III 654752 fabH 4551629 fabH Mycobacterium ulcerans Agy99 3-oxoacyl-(acyl carrier protein) synthase III YP_904768.1 653745 R 362242 CDS YP_904769.1 118616437 4551630 complement(654851..655777) 1 NC_008611.1 catalyzes the formation of dimethylmenaquinone from 1,4-dihydroxy-2-naphthoate and octaprenyl diphosphate; 1,4-dihydroxy-2-naphthoate octaprenyltransferase 655777 menA 4551630 menA Mycobacterium ulcerans Agy99 1,4-dihydroxy-2-naphthoate octaprenyltransferase YP_904769.1 654851 R 362242 CDS YP_904770.1 118616438 4551631 655767..656561 1 NC_008611.1 Catalyzes the reversible phosphorolysis of 5'-deoxy-5'- methylthioadenosine (MTA) to adenine and 5-methylthio-D-ribose-1- phosphate; 5'-methylthioadenosine phosphorylase 656561 pnp 4551631 pnp Mycobacterium ulcerans Agy99 5'-methylthioadenosine phosphorylase YP_904770.1 655767 D 362242 CDS YP_904771.1 118616439 4551632 656558..657598 1 NC_008611.1 cytoplasmic protein; involved in galactose metabolism [catalytic activity: UDP-glucose = UDP-galactose]; UDP-glucose 4-epimerase, GalE3 657598 galE3 4551632 galE3 Mycobacterium ulcerans Agy99 UDP-glucose 4-epimerase, GalE3 YP_904771.1 656558 D 362242 CDS YP_904772.1 118616440 4551633 complement(657606..659228) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; hypothetical protein 659228 4551633 MUL_0636 Mycobacterium ulcerans Agy99 hypothetical protein YP_904772.1 657606 R 362242 CDS YP_904773.1 118616441 4551634 659546..661390 1 NC_008611.1 membrane protein; hypothetical protein 661390 4551634 MUL_0637 Mycobacterium ulcerans Agy99 hypothetical protein YP_904773.1 659546 D 362242 CDS YP_904774.1 118616442 4551635 661420..662076 1 NC_008611.1 cytoplasmic protein; substrate (sugar) unknown [catalytic activity: NDP- sugar + dolichyl phosphate = NDP + dolichyl sugar phosphate]; glycosyl transferase - dolichol-P-sugar synthase 662076 4551635 MUL_0638 Mycobacterium ulcerans Agy99 glycosyl transferase - dolichol-P-sugar synthase YP_904774.1 661420 D 362242 CDS YP_904775.1 118616443 4551636 662073..662735 1 NC_008611.1 cytoplasmic protein; hypothetical protein 662735 4551636 MUL_0639 Mycobacterium ulcerans Agy99 hypothetical protein YP_904775.1 662073 D 362242 CDS YP_904776.1 118616444 4551637 complement(662767..664119) 1 NC_008611.1 membrane protein; hypothetical protein 664119 4551637 MUL_0640 Mycobacterium ulcerans Agy99 hypothetical protein YP_904776.1 662767 R 362242 CDS YP_904777.1 118616445 4551805 complement(664131..665240) 1 NC_008611.1 cytoplasmic protein; involved in menaquinone biosynthesis. O- succinylbenzoic acid (OSB) to O-succinylbenzoyl-CoA (OSB- CoA) [catalytic activity: ATP + O-succinylbenzoate + CoA = AMP + diphosphate + O-succinylbenzoyl-CoA]; O-succinylbenzoic acid--CoA ligase 665240 menE 4551805 menE Mycobacterium ulcerans Agy99 O-succinylbenzoic acid--CoA ligase YP_904777.1 664131 R 362242 CDS YP_904778.1 118616446 4551806 complement(665285..665581) 1 NC_008611.1 Detected in the membrane fraction by proteomics (2D- LC-MS/MS); cytoplasmic protein; hypothetical protein 665581 4551806 MUL_0642 Mycobacterium ulcerans Agy99 hypothetical protein YP_904778.1 665285 R 362242 CDS YP_904779.1 118616447 4551807 complement(665641..665925) 1 NC_008611.1 membrane protein; hypothetical protein 665925 4551807 MUL_0643 Mycobacterium ulcerans Agy99 hypothetical protein YP_904779.1 665641 R 362242 CDS YP_904780.1 118616448 4551809 complement(667315..667722) 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; hypothetical protein 667722 4551809 MUL_0645 Mycobacterium ulcerans Agy99 hypothetical protein YP_904780.1 667315 R 362242 CDS YP_904781.1 118616449 4551810 complement(667736..668365) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 668365 4551810 MUL_0646 Mycobacterium ulcerans Agy99 hypothetical protein YP_904781.1 667736 R 362242 CDS YP_904782.1 118616450 4551811 complement(668384..669271) 1 NC_008611.1 Detected in the membrane fraction by proteomics. Also detected in the cytoplasmic fraction by 2D-LC-MS/MS.; cytoplasmic protein; short chain dehydrogenase 669271 4551811 MUL_0647 Mycobacterium ulcerans Agy99 short chain dehydrogenase YP_904782.1 668384 R 362242 CDS YP_904783.1 118616451 4551812 complement(669315..670217) 1 NC_008611.1 catalyzes the formation of 1,4-dihydroxy-2-naphthoate from O-succinylbenzoyl-CoA; naphthoate synthase 670217 menB 4551812 menB Mycobacterium ulcerans Agy99 naphthoate synthase YP_904783.1 669315 R 362242 CDS YP_904784.1 118616452 4551813 complement(670214..670549) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 670549 4551813 MUL_0649 Mycobacterium ulcerans Agy99 hypothetical protein YP_904784.1 670214 R 362242 CDS YP_904785.1 118616453 4551814 complement(671026..672627) 1 NC_008611.1 activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 672627 fadD8 4551814 fadD8 Mycobacterium ulcerans Agy99 acyl-CoA synthetase YP_904785.1 671026 R 362242 CDS YP_904786.1 118616454 4551815 672716..674320 1 NC_008611.1 membrane protein; has significant domain identity to predicted metal- dependent hydrolases; hypothetical protein 674320 4551815 MUL_0651 Mycobacterium ulcerans Agy99 hypothetical protein YP_904786.1 672716 D 362242 CDS YP_904787.1 118616455 4551816 674317..675300 1 NC_008611.1 catalyzes the dehydration of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid to form O-succinylbenzoate; O-succinylbenzoate synthase 675300 menC 4551816 menC Mycobacterium ulcerans Agy99 O-succinylbenzoate synthase YP_904787.1 674317 D 362242 CDS YP_904788.1 118616456 4551817 675293..676081 1 NC_008611.1 Detected in the membrane fraction by proteomics (2D- LC-MS/MS); membrane protein; non-haem peroxidase; bromoperoxidase BpoC 676081 bpoC 4551817 bpoC Mycobacterium ulcerans Agy99 bromoperoxidase BpoC YP_904788.1 675293 D 362242 CDS YP_904789.1 118616457 4551818 676145..677791 1 NC_008611.1 SEPHCHC synthase; forms 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1- carboxylate from 2-oxoglutarate and isochorismate in menaquinone biosynthesis; 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate synthase 677791 menD 4551818 menD Mycobacterium ulcerans Agy99 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate synthase YP_904789.1 676145 D 362242 CDS YP_904790.1 118616458 4551819 677788..678312 1 NC_008611.1 membrane protein; hypothetical protein 678312 4551819 MUL_0655 Mycobacterium ulcerans Agy99 hypothetical protein YP_904790.1 677788 D 362242 CDS YP_904791.1 118616459 4551820 678388..679539 1 NC_008611.1 cytoplasmic protein; involved in lipoarabinomannan (lam) biosynthesis.; mannosyltransferase, PimB 679539 pimB 4551820 pimB Mycobacterium ulcerans Agy99 mannosyltransferase, PimB YP_904791.1 678388 D 362242 CDS YP_904792.1 118616460 4551821 complement(679536..680138) 1 NC_008611.1 cytoplasmic protein; function unknown, mar family; transcriptional regulator 680138 4551821 MUL_0657 Mycobacterium ulcerans Agy99 transcriptional regulator YP_904792.1 679536 R 362242 CDS YP_904793.1 118616461 4551822 680149..681342 1 NC_008611.1 cytoplasmic protein; hypothetical protein 681342 4551822 MUL_0658 Mycobacterium ulcerans Agy99 hypothetical protein YP_904793.1 680149 D 362242 CDS YP_904794.1 118616462 4551823 681332..682639 1 NC_008611.1 cytoplasmic protein; hypothetical protein 682639 4551823 MUL_0659 Mycobacterium ulcerans Agy99 hypothetical protein YP_904794.1 681332 D 362242 CDS YP_904795.1 118616463 4553382 682668..683363 1 NC_008611.1 Catalyzes the carbon methylation reaction in the biosynthesis of ubiquinone; ubiquinone/menaquinone biosynthesis methyltransferase 683363 ubiE 4553382 ubiE Mycobacterium ulcerans Agy99 ubiquinone/menaquinone biosynthesis methyltransferase YP_904795.1 682668 D 362242 CDS YP_904796.1 118616464 4553383 complement(683382..683717) 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; membrane protein; hypothetical protein 683717 4553383 MUL_0661 Mycobacterium ulcerans Agy99 hypothetical protein YP_904796.1 683382 R 362242 CDS YP_904797.1 118616465 4553384 complement(683707..684438) 1 NC_008611.1 cytoplasmic protein; methyltransferase 684438 4553384 MUL_0662 Mycobacterium ulcerans Agy99 methyltransferase YP_904797.1 683707 R 362242 CDS YP_904798.1 118616466 4553385 complement(684504..685742) 1 NC_008611.1 membrane protein; has significant domain conservation with dehydrogenases (flavoproteins) [energy production and conversion]; FAD-linked oxidoreductase 685742 4553385 MUL_0663 Mycobacterium ulcerans Agy99 FAD-linked oxidoreductase YP_904798.1 684504 R 362242 CDS YP_904799.1 118616467 4553386 685764..686771 1 NC_008611.1 cytoplasmic protein; supplies polyprenyl diphosphate; polyprenyl diphosphate synthetase, GrcC1 686771 grcC1 4553386 grcC1 Mycobacterium ulcerans Agy99 polyprenyl diphosphate synthetase, GrcC1 YP_904799.1 685764 D 362242 CDS YP_904800.1 118616468 4553387 686862..687722 1 NC_008611.1 putative metalloprotease; heat shock protein HtpX 687722 hspX 4553387 hspX Mycobacterium ulcerans Agy99 heat shock protein HtpX YP_904800.1 686862 D 362242 CDS YP_904801.1 118616469 4553388 complement(687743..689344) 1 NC_008611.1 membrane protein; generates CO(2) and H(2)O from H(2)CO(3), and possibly involved in transport of sulfate across the membrane.; transmembrane carbonic anhydrase, SulP 689344 sulP 4553388 sulP Mycobacterium ulcerans Agy99 transmembrane carbonic anhydrase, SulP YP_904801.1 687743 R 362242 CDS YP_904802.1 118616470 4553389 complement(689637..691190) 1 NC_008611.1 membrane protein; frameshift; transmembrane carbonic anhydrase, SulP_1 691190 sulP_1 4553389 sulP_1 Mycobacterium ulcerans Agy99 transmembrane carbonic anhydrase, SulP_1 YP_904802.1 689637 R 362242 CDS YP_904803.1 118616471 4553390 complement(691423..692448) 1 NC_008611.1 catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase 692448 gpdA1 4553390 gpdA1 Mycobacterium ulcerans Agy99 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase YP_904803.1 691423 R 362242 CDS YP_904804.1 118616472 4553391 692900..693595 1 NC_008611.1 membrane protein; hydrolyzes peptides and/or proteins. cleaves preferentially after serine residues; serine protease 693595 4553391 MUL_0668 Mycobacterium ulcerans Agy99 serine protease YP_904804.1 692900 D 362242 CDS YP_904805.1 118616473 4553393 complement(697302..697760) 1 NC_008611.1 cytoplasmic protein; domain identity to N-acetylases of ribosomal proteins; acetyltransferase, RimL 697760 rimL 4553393 rimL Mycobacterium ulcerans Agy99 acetyltransferase, RimL YP_904805.1 697302 R 362242 CDS YP_904806.1 118616474 4553394 complement(697968..698459) 1 NC_008611.1 putative nucleotide binding property based on structural studies of Haemophilus influenzae crystallized protein in PDB Accession Number 1IN0 and NMR studies of Escherichia coli YajQ; the YajQ protein from Pseudomonas synringae appears to play a role in activation of bateriophage phi6 segment L transcription; putative nucleotide-binding protein 698459 4553394 MUL_0671 Mycobacterium ulcerans Agy99 putative nucleotide-binding protein YP_904806.1 697968 R 362242 CDS YP_904807.1 118616475 4553396 complement(698652..700913) 1 NC_008611.1 membrane protein; ABC-type transport system, involved in lipoprotein release, permease component; ABC-type transporter 700913 4553396 MUL_0673 Mycobacterium ulcerans Agy99 ABC-type transporter YP_904807.1 698652 R 362242 CDS YP_904808.1 118616476 4553397 complement(701006..701740) 1 NC_008611.1 membrane protein; ABC transporter, ATP-binding protein 701740 4553397 MUL_0674 Mycobacterium ulcerans Agy99 ABC transporter, ATP-binding protein YP_904808.1 701006 R 362242 CDS YP_904809.1 118616477 4553398 complement(701737..702342) 1 NC_008611.1 cytoplasmic protein; involved in transcriptional mechanism.; transcriptional regulator 702342 4553398 MUL_0675 Mycobacterium ulcerans Agy99 transcriptional regulator YP_904809.1 701737 R 362242 CDS YP_904810.1 118616478 4553399 complement(702465..703277) 1 NC_008611.1 cytoplasmic protein; carveol-like dehydrogenase 703277 4553399 MUL_0676 Mycobacterium ulcerans Agy99 carveol-like dehydrogenase YP_904810.1 702465 R 362242 CDS YP_904811.1 118616479 4553400 complement(703399..704619) 1 NC_008611.1 membrane protein; NhaP-type Na+/H+ and K+/H+ antiporter: inorganic ion transport and metabolism] antiporters are ubiquitous membrane proteins that are involved in homeostasis of H(+) and na(+) throughout the biological kingdom.; ion antiporter, NhaP 704619 nhaP 4553400 nhaP Mycobacterium ulcerans Agy99 ion antiporter, NhaP YP_904811.1 703399 R 362242 CDS YP_904812.1 118616480 4554462 complement(704778..705824) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 705824 4554462 MUL_0678 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_904812.1 704778 R 362242 CDS YP_904813.1 118616481 4554463 706434..706631 1 NC_008611.1 hypothetical protein 706631 4554463 MUL_0679 Mycobacterium ulcerans Agy99 hypothetical protein YP_904813.1 706434 D 362242 CDS YP_904814.1 118616482 4554465 707984..708607 1 NC_008611.1 cytoplasmic protein; involved in transcriptional mechanism.; TetR family transcriptional regulator 708607 4554465 MUL_0681 Mycobacterium ulcerans Agy99 TetR family transcriptional regulator YP_904814.1 707984 D 362242 CDS YP_904815.1 118616483 4554469 710901..711080 1 NC_008611.1 membrane protein; hypothetical protein 711080 4554469 MUL_0685 Mycobacterium ulcerans Agy99 hypothetical protein YP_904815.1 710901 D 362242 CDS YP_904816.1 118616484 4554470 711204..712226 1 NC_008611.1 cytoplasmic protein; methyltransferase/methylase 712226 4554470 MUL_0686 Mycobacterium ulcerans Agy99 methyltransferase/methylase YP_904816.1 711204 D 362242 CDS YP_904817.1 118616485 4554471 712367..713098 1 NC_008611.1 cytoplasmic protein; adenylate cyclase 713098 4554471 MUL_0687 Mycobacterium ulcerans Agy99 adenylate cyclase YP_904817.1 712367 D 362242 CDS YP_904818.1 118616486 4554473 715636..717156 1 NC_008611.1 cytoplasmic protein; component of the translational apparatus. furnishes a means for formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. the reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-glu-tRNA(Gln) [catalytic activity: ATP + L-glutamyl-tRNA(Gln) + L- glutamine = ADP + phosphate + L-glutaminyl-tRNA(Gln) + L- glutamate]; peptide amidase, GatA_1 717156 gatA_1 4554473 gatA_1 Mycobacterium ulcerans Agy99 peptide amidase, GatA_1 YP_904818.1 715636 D 362242 CDS YP_904819.1 118616487 4554474 complement(717353..717700) 1 NC_008611.1 cytoplasmic protein; oxidoreductase 717700 4554474 MUL_0690 Mycobacterium ulcerans Agy99 oxidoreductase YP_904819.1 717353 R 362242 CDS YP_904820.1 118616488 4554475 717732..718889 1 NC_008611.1 membrane protein; involved in galactose metabolism (Leloir pathway) [catalytic activity: UTP + alpha-D-galactose 1-phosphate = diphosphate + UDP-galactose]; galactose-1-phosphate uridylyltransferase, GalT 718889 galT 4554475 galT Mycobacterium ulcerans Agy99 galactose-1-phosphate uridylyltransferase, GalT YP_904820.1 717732 D 362242 CDS YP_904821.1 118616489 4554476 718886..719986 1 NC_008611.1 catalyzes the formation of alpha-D-galactose 1-phosphate from D-galactose in galactose metabolism; galactokinase 719986 galK 4554476 galK Mycobacterium ulcerans Agy99 galactokinase YP_904821.1 718886 D 362242 CDS YP_904822.1 118616490 4554477 719983..721089 1 NC_008611.1 membrane protein; ArsR family; transcriptional regulator 721089 4554477 MUL_0693 Mycobacterium ulcerans Agy99 transcriptional regulator YP_904822.1 719983 D 362242 CDS YP_904823.1 118616491 4553823 724517..725329 1 NC_008611.1 cytoplasmic protein; hypothetical protein 725329 4553823 MUL_0695 Mycobacterium ulcerans Agy99 hypothetical protein YP_904823.1 724517 D 362242 CDS YP_904824.1 118616492 4553826 complement(728621..730093) 1 NC_008611.1 membrane protein; contains hydrolase domain; hypothetical protein 730093 4553826 MUL_0698 Mycobacterium ulcerans Agy99 hypothetical protein YP_904824.1 728621 R 362242 CDS YP_904825.1 118616493 4553827 complement(730021..730602) 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; hypothetical protein 730602 4553827 MUL_0699 Mycobacterium ulcerans Agy99 hypothetical protein YP_904825.1 730021 R 362242 CDS YP_904826.1 118616494 4553828 complement(730716..732011) 1 NC_008611.1 membrane protein; lipoprotein, LppF 732011 lppF 4553828 lppF Mycobacterium ulcerans Agy99 lipoprotein, LppF YP_904826.1 730716 R 362242 CDS YP_904827.1 118616495 4553829 complement(732215..732895) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; lipoprotein, LpqN 732895 lpqN 4553829 lpqN Mycobacterium ulcerans Agy99 lipoprotein, LpqN YP_904827.1 732215 R 362242 CDS YP_904828.1 118616496 4553830 732899..733135 1 NC_008611.1 hypothetical protein 733135 4553830 MUL_0702 Mycobacterium ulcerans Agy99 hypothetical protein YP_904828.1 732899 D 362242 CDS YP_904829.1 118616497 4553832 complement(735808..738183) 1 NC_008611.1 Also detected in the cytoplamic fraction by LCMSMS; membrane protein; integral membrane protein 738183 4553832 MUL_0704 Mycobacterium ulcerans Agy99 integral membrane protein YP_904829.1 735808 R 362242 CDS YP_904830.1 118616498 4553833 complement(738681..739943) 1 NC_008611.1 cytoplasmic protein; function unknown, imidazolonepropionase is an amidohydrolase; imidazolonepropionase 739943 4553833 MUL_0705 Mycobacterium ulcerans Agy99 imidazolonepropionase YP_904830.1 738681 R 362242 CDS YP_904831.1 118616499 4553834 740075..741016 1 NC_008611.1 cytoplasmic protein; hypothetical protein 741016 4553834 MUL_0706 Mycobacterium ulcerans Agy99 hypothetical protein YP_904831.1 740075 D 362242 CDS YP_904832.1 118616500 4553835 complement(741037..742800) 1 NC_008611.1 cytoplasmic protein; involved in homologous recombination; exodeoxyribonuclease V (alpha chain), RecD 742800 recD 4553835 recD Mycobacterium ulcerans Agy99 exodeoxyribonuclease V (alpha chain), RecD YP_904832.1 741037 R 362242 CDS YP_904833.1 118616501 4553836 complement(742797..746129) 1 NC_008611.1 cytoplasmic protein; involved in homologous recombination.; exodeoxyribonuclease V (beta chain), RecB 746129 recB 4553836 recB Mycobacterium ulcerans Agy99 exodeoxyribonuclease V (beta chain), RecB YP_904833.1 742797 R 362242 CDS YP_904834.1 118616502 4553837 complement(746129..749428) 1 NC_008611.1 cytoplasmic protein; involved in homologous recombination; exodeoxyribonuclease V (gamma chain), RecC 749428 recC 4553837 recC Mycobacterium ulcerans Agy99 exodeoxyribonuclease V (gamma chain), RecC YP_904834.1 746129 R 362242 CDS YP_904835.1 118616503 4553838 749470..749919 1 NC_008611.1 membrane protein; nitroreductase 749919 4553838 MUL_0710 Mycobacterium ulcerans Agy99 nitroreductase YP_904835.1 749470 D 362242 CDS YP_904836.1 118616504 4553839 750066..750542 1 NC_008611.1 catalyzes the reaction of cyanate and bicarbonate to produce ammonia and carbon dioxide; cyanate hydratase 750542 cynS 4553839 cynS Mycobacterium ulcerans Agy99 cyanate hydratase YP_904836.1 750066 D 362242 CDS YP_904837.1 118616505 4552571 complement(751598..752293) 1 NC_008611.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 752293 echA3 4552571 echA3 Mycobacterium ulcerans Agy99 enoyl-CoA hydratase YP_904837.1 751598 R 362242 CDS YP_904838.1 118616506 4552572 complement(752375..753247) 1 NC_008611.1 membrane protein; hypothetical protein 753247 4552572 MUL_0714 Mycobacterium ulcerans Agy99 hypothetical protein YP_904838.1 752375 R 362242 CDS YP_904839.1 118616507 4552573 complement(753399..754115) 1 NC_008611.1 Detected in the cytoplasmic fraction by proteomics.; cytoplasmic protein; thought to be involved in glyoxal pathway. thioesterase that catalyses the hydrolysis of S-D-lactoyl- glutathione to form glutathione and D-lactic acid [catalytic activity: (S)-(2-hydroxyacyl)glutathione + H2O = glutathione + a 2-hydroxy acid anion]; glyoxalase II, GloB 754115 gloB 4552573 gloB Mycobacterium ulcerans Agy99 glyoxalase II, GloB YP_904839.1 753399 R 362242 CDS YP_904840.1 118616508 4552574 754239..754448 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; domain homology to Arc/MetJ class transcription regulators; hypothetical protein 754448 4552574 MUL_0716 Mycobacterium ulcerans Agy99 hypothetical protein YP_904840.1 754239 D 362242 CDS YP_904841.1 118616509 4552577 754836..755003 1 NC_008611.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group have the CXXC motif; 50S ribosomal protein L33 755003 rpmG 4552577 rpmG Mycobacterium ulcerans Agy99 50S ribosomal protein L33 YP_904841.1 754836 D 362242 CDS YP_904842.1 118616510 4552578 755054..755533 1 NC_008611.1 functions as a heterodimer along with HadB in fatty acid biosynthesis; fatty acid synthase type II; FAS-II; (3R)-hydroxyacyl-ACP dehydratase subunit HadA 755533 4552578 MUL_0720 Mycobacterium ulcerans Agy99 (3R)-hydroxyacyl-ACP dehydratase subunit HadA YP_904842.1 755054 D 362242 CDS YP_904843.1 118616511 4552579 755520..755948 1 NC_008611.1 functions as a heterodimer along with HadA or HadC in fatty acid biosynthesis; fatty acid synthase type II; FAS-II; (3R)-hydroxyacyl-ACP dehydratase subunit HadB 755948 4552579 MUL_0721 Mycobacterium ulcerans Agy99 (3R)-hydroxyacyl-ACP dehydratase subunit HadB YP_904843.1 755520 D 362242 CDS YP_904844.1 118616512 4552580 755959..756459 1 NC_008611.1 functions as a heterodimer along with HadB in fatty acid biosynthesis; fatty acid synthase type II; FAS-II; (3R)-hydroxyacyl-ACP dehydratase subunit HadC 756459 4552580 MUL_0722 Mycobacterium ulcerans Agy99 (3R)-hydroxyacyl-ACP dehydratase subunit HadC YP_904844.1 755959 D 362242 CDS YP_904845.1 118616513 4552582 756828..757316 1 NC_008611.1 forms a complex with SecY and SecG; SecYEG forms a putative protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force; preprotein translocase subunit SecE 757316 secE 4552582 secE Mycobacterium ulcerans Agy99 preprotein translocase subunit SecE YP_904845.1 756828 D 362242 CDS YP_904846.1 118616514 4552583 757348..758061 1 NC_008611.1 Modulates Rho-dependent transcription termination; transcription antitermination protein NusG 758061 nusG 4552583 nusG Mycobacterium ulcerans Agy99 transcription antitermination protein NusG YP_904846.1 757348 D 362242 CDS YP_904847.1 118616515 4552584 758108..758536 1 NC_008611.1 binds directly to 23S ribosomal RNA; 50S ribosomal protein L11 758536 rplK 4552584 rplK Mycobacterium ulcerans Agy99 50S ribosomal protein L11 YP_904847.1 758108 D 362242 CDS YP_904848.1 118616516 4552585 758624..759331 1 NC_008611.1 in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA; 50S ribosomal protein L1 759331 rplA 4552585 rplA Mycobacterium ulcerans Agy99 50S ribosomal protein L1 YP_904848.1 758624 D 362242 CDS YP_904849.1 118616517 4552128 complement(761462..762400) 1 NC_008611.1 Detected in the cytoplamic fraction by LC-MS/MS. Detected in the membrane fraction by proteomics (2D-LC- MS/MS); cytoplasmic protein; methyltransferase. involved in mycolic acids modification. catalyzes unusual S-adenosyl-methionine- dependent transformation of a cis-olefin mycolic acid into a secondary alcohol. catalyzes introduction of a hydroxyl group at the distal position on mycolic acid chains to produce the hydroxyl mycolate. mycolic acids represent a major constituent of the mycobacterial cell wall complex. methyl transfer results in formation of a secondary hydroxy group with an adjacent methyl branch; olefinic mycolic acid methyl transferase.; methoxy mycolic acid synthase 4, MmaA4 762400 mmaA4 4552128 mmaA4 Mycobacterium ulcerans Agy99 methoxy mycolic acid synthase 4, MmaA4 YP_904849.1 761462 R 362242 CDS YP_904850.1 118616518 4552129 complement(762504..763385) 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; methyltransferase involved in mycolic acid biosynthesis; methoxy mycolic acid synthase 3, MmaA3 763385 mmaA3 4552129 mmaA3 Mycobacterium ulcerans Agy99 methoxy mycolic acid synthase 3, MmaA3 YP_904850.1 762504 R 362242 CDS YP_904851.1 118616519 4552130 complement(763669..764385) 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; methyltransferase involved in mycolic acid biosynthesis; methoxy mycolic acid synthase 2, MmaA2 764385 mmaA2 4552130 mmaA2 Mycobacterium ulcerans Agy99 methoxy mycolic acid synthase 2, MmaA2 YP_904851.1 763669 R 362242 CDS YP_904852.1 118616520 4552132 complement(765500..766444) 1 NC_008611.1 membrane protein; lipase/esterase LipG1 766444 lipG1 4552132 lipG1 Mycobacterium ulcerans Agy99 lipase/esterase LipG1 YP_904852.1 765500 R 362242 CDS YP_904853.1 118616521 4552133 complement(766454..767869) 1 NC_008611.1 cytoplasmic protein; contains a kinase domain and ATP-binding cassette; hypothetical protein 767869 4552133 MUL_0734 Mycobacterium ulcerans Agy99 hypothetical protein YP_904853.1 766454 R 362242 CDS YP_904854.1 118616522 4552134 complement(767959..768870) 1 NC_008611.1 cytoplasmic protein; lipase/esterase LipG2 768870 lipG2 4552134 lipG2 Mycobacterium ulcerans Agy99 lipase/esterase LipG2 YP_904854.1 767959 R 362242 CDS YP_904855.1 118616523 4552136 770468..774556 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; alpha-mannosidase activity: hydrolysis of terminal non-reducing alpha-D-mannose residues in alpha-D- mannosides.; alpha-mannosidase 774556 4552136 MUL_0737 Mycobacterium ulcerans Agy99 alpha-mannosidase YP_904855.1 770468 D 362242 CDS YP_904856.1 118616524 4552137 774578..775039 1 NC_008611.1 cytoplasmic protein; nvolved in lipid metabolism; fatty acid biosynthesis [catalytic activity: malonyl-CoA + [acyl- carrier protein] = CoA + malonyl-[acyl-carrier protein]]; malonyl CoA-acyl carrier protein transacylase, FabD2 775039 fabD2 4552137 fabD2 Mycobacterium ulcerans Agy99 malonyl CoA-acyl carrier protein transacylase, FabD2 YP_904856.1 774578 D 362242 CDS YP_904857.1 118616525 4552138 775046..775954 1 NC_008611.1 function unknown; probably involved in specific sugar metabolism or regulation; carbohydrate kinase 775954 4552138 MUL_0739 Mycobacterium ulcerans Agy99 carbohydrate kinase YP_904857.1 775046 D 362242 CDS YP_904858.1 118616526 4552139 776374..778350 1 NC_008611.1 membrane protein; PE-PGRS family protein 778350 4552139 MUL_0740 Mycobacterium ulcerans Agy99 PE-PGRS family protein YP_904858.1 776374 D 362242 CDS YP_904859.1 118616527 4552140 778725..779345 1 NC_008611.1 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit; 50S ribosomal protein L10 779345 rplJ 4552140 rplJ Mycobacterium ulcerans Agy99 50S ribosomal protein L10 YP_904859.1 778725 D 362242 CDS YP_904860.1 118616528 4552141 779413..779805 1 NC_008611.1 present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors; 50S ribosomal protein L7/L12 779805 rplL 4552141 rplL Mycobacterium ulcerans Agy99 50S ribosomal protein L7/L12 YP_904860.1 779413 D 362242 CDS YP_904861.1 118616529 4552142 complement(779869..780606) 1 NC_008611.1 cytoplasmic protein; function unknown, involved in transcriptional mechanism; transcriptional regulatory protein 780606 4552142 MUL_0743 Mycobacterium ulcerans Agy99 transcriptional regulatory protein YP_904861.1 779869 R 362242 CDS YP_904862.1 118616530 4552143 780678..782180 1 NC_008611.1 Detected in the membrane fraction by proteomics (2D- LC-MS/MS); cytoplasmic protein; dioxygenase and related enzymes [secondary metabolites biosynthesis, transport, and catabolism]; dioxygenase 782180 4552143 MUL_0744 Mycobacterium ulcerans Agy99 dioxygenase YP_904862.1 780678 D 362242 CDS YP_904863.1 118616531 4552144 782359..783345 1 NC_008611.1 Detected in the membrane fraction by proteomics (2D- LC-MS/MS) Also detected in the cytoplasmic fraction by 2D- LC-MS/MS.; membrane protein; thought to be involved in active transport of ribonucleotide across the membrane. responsible for energy coupling to the transport system.; ribonucleotide-transport ATP-binding protein ABC transporter, Mkl 783345 mkl 4552144 mkl Mycobacterium ulcerans Agy99 ribonucleotide-transport ATP-binding protein ABC transporter, Mkl YP_904863.1 782359 D 362242 CDS YP_904864.1 118616532 4552145 783938..787468 1 NC_008611.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme; DNA-directed RNA polymerase subunit beta 787468 rpoB 4552145 rpoB Mycobacterium ulcerans Agy99 DNA-directed RNA polymerase subunit beta YP_904864.1 783938 D 362242 CDS YP_904865.1 118616533 4552035 787521..791471 1 NC_008611.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter; DNA-directed RNA polymerase subunit beta' 791471 rpoC 4552035 rpoC Mycobacterium ulcerans Agy99 DNA-directed RNA polymerase subunit beta' YP_904865.1 787521 D 362242 CDS YP_904866.1 118616534 4552036 792135..792326 1 NC_008611.1 membrane protein; PE-PGRS family protein 792326 4552036 MUL_0748 Mycobacterium ulcerans Agy99 PE-PGRS family protein YP_904866.1 792135 D 362242 CDS YP_904867.1 118616535 4552039 795440..796198 1 NC_008611.1 Assists in DNA repair by cleaving phosphodiester bonds at apurinic or apyrimidinic sties to produce new 5' ends that are base-free deoxyribose 5-phosphate residues; endonuclease IV 796198 end 4552039 end Mycobacterium ulcerans Agy99 endonuclease IV YP_904867.1 795440 D 362242 CDS YP_904868.1 118616536 4552040 796263..796919 1 NC_008611.1 membrane protein; lipoprotein, LpqP 796919 lpqP 4552040 lpqP Mycobacterium ulcerans Agy99 lipoprotein, LpqP YP_904868.1 796263 D 362242 CDS YP_904869.1 118616537 4552041 797119..798780 1 NC_008611.1 cytoplasmic protein; may be involved in lipid degradation; acyl-CoA dehydrogenase 798780 4552041 MUL_0753 Mycobacterium ulcerans Agy99 acyl-CoA dehydrogenase YP_904869.1 797119 D 362242 CDS YP_904870.1 118616538 4552042 798789..799727 1 NC_008611.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 799727 echA4 4552042 echA4 Mycobacterium ulcerans Agy99 enoyl-CoA hydratase YP_904870.1 798789 D 362242 CDS YP_904871.1 118616539 4552043 799741..800472 1 NC_008611.1 membrane protein; high domain identity with transcriptional repressors; putative regulatory protein 800472 4552043 MUL_0755 Mycobacterium ulcerans Agy99 putative regulatory protein YP_904871.1 799741 D 362242 CDS YP_904872.1 118616540 4552044 800469..801242 1 NC_008611.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 801242 echA5 4552044 echA5 Mycobacterium ulcerans Agy99 enoyl-CoA hydratase YP_904872.1 800469 D 362242 CDS YP_904873.1 118616541 4552045 complement(801299..804199) 1 NC_008611.1 Detected in the membrane fraction by proteomics (2D- LC-MS/MS); membrane protein; thought to be involved in fatty acid transport; transmembrane transport protein, MmpL5 804199 mmpL5 4552045 mmpL5 Mycobacterium ulcerans Agy99 transmembrane transport protein, MmpL5 YP_904873.1 801299 R 362242 CDS YP_904874.1 118616542 4552046 complement(804196..804624) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; transmembrane proteinm, MmpS5 804624 mmpS5 4552046 mmpS5 Mycobacterium ulcerans Agy99 transmembrane proteinm, MmpS5 YP_904874.1 804196 R 362242 CDS YP_904875.1 118616543 4552047 804808..805308 1 NC_008611.1 cytoplasmic protein; transcriptional regulator 805308 4552047 MUL_0759 Mycobacterium ulcerans Agy99 transcriptional regulator YP_904875.1 804808 D 362242 CDS YP_904876.1 118616544 4552048 complement(805358..805747) 1 NC_008611.1 membrane protein; hypothetical protein 805747 4552048 MUL_0760 Mycobacterium ulcerans Agy99 hypothetical protein YP_904876.1 805358 R 362242 CDS YP_904877.1 118616545 4552049 complement(805885..806262) 1 NC_008611.1 membrane protein; hypothetical protein 806262 4552049 MUL_0761 Mycobacterium ulcerans Agy99 hypothetical protein YP_904877.1 805885 R 362242 CDS YP_904878.1 118616546 4552050 806526..807173 1 NC_008611.1 cytoplasmic protein; involved in transcriptional mechanism.; TetR family transcriptional regulator 807173 4552050 MUL_0762 Mycobacterium ulcerans Agy99 TetR family transcriptional regulator YP_904878.1 806526 D 362242 CDS YP_904879.1 118616547 4552051 807549..807923 1 NC_008611.1 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance; 30S ribosomal protein S12 807923 rpsL 4552051 rpsL Mycobacterium ulcerans Agy99 30S ribosomal protein S12 YP_904879.1 807549 D 362242 CDS YP_904880.1 118616548 4552052 807923..808393 1 NC_008611.1 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit; 30S ribosomal protein S7 808393 rpsG 4552052 rpsG Mycobacterium ulcerans Agy99 30S ribosomal protein S7 YP_904880.1 807923 D 362242 CDS YP_904881.1 118616549 4552053 808474..810579 1 NC_008611.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene; elongation factor G 810579 fusA1 4552053 fusA1 Mycobacterium ulcerans Agy99 elongation factor G YP_904881.1 808474 D 362242 CDS YP_904882.1 118616550 4551894 810766..811956 1 NC_008611.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu 811956 tuf 4551894 tuf Mycobacterium ulcerans Agy99 elongation factor Tu YP_904882.1 810766 D 362242 CDS YP_904883.1 118616551 4551895 812206..813015 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; hypothetical protein 813015 4551895 MUL_0767 Mycobacterium ulcerans Agy99 hypothetical protein YP_904883.1 812206 D 362242 CDS YP_904884.1 118616552 4551896 813228..813974 1 NC_008611.1 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-(acyl-carrier-protein) reductase 813974 4551896 MUL_0768 Mycobacterium ulcerans Agy99 3-ketoacyl-(acyl-carrier-protein) reductase YP_904884.1 813228 D 362242 CDS YP_904885.1 118616553 4551897 813984..815414 1 NC_008611.1 cytoplasmic protein; ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.; ferredoxin reductase 815414 4551897 MUL_0769 Mycobacterium ulcerans Agy99 ferredoxin reductase YP_904885.1 813984 D 362242 CDS YP_904886.1 118616554 4551898 complement(815320..816381) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 816381 4551898 MUL_0770 Mycobacterium ulcerans Agy99 hypothetical protein YP_904886.1 815320 R 362242 CDS YP_904887.1 118616555 4551899 complement(816381..816974) 1 NC_008611.1 cytoplasmic protein; involved in transcriptional mechanism.; transcriptional regulator 816974 4551899 MUL_0771 Mycobacterium ulcerans Agy99 transcriptional regulator YP_904887.1 816381 R 362242 CDS YP_904888.1 118616556 4551900 817173..817502 1 NC_008611.1 hypothetical protein 817502 4551900 MUL_0772 Mycobacterium ulcerans Agy99 hypothetical protein YP_904888.1 817173 D 362242 CDS YP_904889.1 118616557 4551901 817499..818608 1 NC_008611.1 cytoplasmic protein; required for coenzyme pyrrolo-quinoline-quinone (PQQ) biosynthesis.; coenzyme PQQ synthesis protein E, PqqE 818608 pqqE 4551901 pqqE Mycobacterium ulcerans Agy99 coenzyme PQQ synthesis protein E, PqqE YP_904889.1 817499 D 362242 CDS YP_904890.1 118616558 4551902 818679..819851 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; involved in respiration; catalyzes conversion of lactate into pyruvate [catalytic activity: (S)-lactate + 2 ferricytochrome C = pyruvate + 2 ferrocytochrome C]; L-lactate dehydrogenase (cytochrome) LldD1 819851 lldD1 4551902 lldD1 Mycobacterium ulcerans Agy99 L-lactate dehydrogenase (cytochrome) LldD1 YP_904890.1 818679 D 362242 CDS YP_904891.1 118616559 4551903 820006..820758 1 NC_008611.1 cytoplasmic protein; catalyses the hydrolysis of creatinine to creatine; creatinine amidohydrolase 820758 4551903 MUL_0775 Mycobacterium ulcerans Agy99 creatinine amidohydrolase YP_904891.1 820006 D 362242 CDS YP_904892.1 118616560 4551904 820755..822167 1 NC_008611.1 membrane protein; membrane glycosyl transferase 822167 4551904 MUL_0776 Mycobacterium ulcerans Agy99 membrane glycosyl transferase YP_904892.1 820755 D 362242 CDS YP_904893.1 118616561 4551905 822176..823612 1 NC_008611.1 membrane protein; dehydrogenase 823612 4551905 MUL_0777 Mycobacterium ulcerans Agy99 dehydrogenase YP_904893.1 822176 D 362242 CDS YP_904894.1 118616562 4551906 complement(823602..824255) 1 NC_008611.1 cytoplasmic protein; involved in transcriptional mechanism.; TetR family transcriptional regulator 824255 4551906 MUL_0778 Mycobacterium ulcerans Agy99 TetR family transcriptional regulator YP_904894.1 823602 R 362242 CDS YP_904895.1 118616563 4551908 complement(826603..827946) 1 NC_008611.1 cytoplasmic protein; required for the transposition of the insertion element IS2606.; transposase for IS2606 827946 4551908 MUL_0780 Mycobacterium ulcerans Agy99 transposase for IS2606 YP_904895.1 826603 R 362242 CDS YP_904896.1 118616564 4551909 828377..829381 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 829381 4551909 MUL_0781 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_904896.1 828377 D 362242 CDS YP_904897.1 118616565 4551910 829924..831396 1 NC_008611.1 cytoplasmic protein; C-term truncated by IS2606 insertion; PPE family protein 831396 4551910 MUL_0782 Mycobacterium ulcerans Agy99 PPE family protein YP_904897.1 829924 D 362242 CDS YP_904898.1 118616566 4551528 complement(832513..832830) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; C-term transposase for IS2404 832830 4551528 MUL_0784 Mycobacterium ulcerans Agy99 C-term transposase for IS2404 YP_904898.1 832513 R 362242 CDS YP_904899.1 118616567 4551529 complement(832855..833559) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; N-term transposase for IS2404 833559 4551529 MUL_0785 Mycobacterium ulcerans Agy99 N-term transposase for IS2404 YP_904899.1 832855 R 362242 CDS YP_904900.1 118616568 4551531 834619..835986 1 NC_008611.1 membrane protein; lipase 835986 4551531 MUL_0787 Mycobacterium ulcerans Agy99 lipase YP_904900.1 834619 D 362242 CDS YP_904901.1 118616569 4551532 835919..836239 1 NC_008611.1 cytoplasmic protein; hypothetical protein 836239 4551532 MUL_0788 Mycobacterium ulcerans Agy99 hypothetical protein YP_904901.1 835919 D 362242 CDS YP_904902.1 118616570 4551533 836530..836835 1 NC_008611.1 NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex; 30S ribosomal protein S10 836835 rpsJ 4551533 rpsJ Mycobacterium ulcerans Agy99 30S ribosomal protein S10 YP_904902.1 836530 D 362242 CDS YP_904903.1 118616571 4551534 836850..837503 1 NC_008611.1 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin; 50S ribosomal protein L3 837503 rplC 4551534 rplC Mycobacterium ulcerans Agy99 50S ribosomal protein L3 YP_904903.1 836850 D 362242 CDS YP_904904.1 118616572 4551535 837503..838177 1 NC_008611.1 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA; 50S ribosomal protein L4 838177 rplD 4551535 rplD Mycobacterium ulcerans Agy99 50S ribosomal protein L4 YP_904904.1 837503 D 362242 CDS YP_904905.1 118616573 4551536 838177..838479 1 NC_008611.1 binds third domain of 23S rRNA and protein L29; part of exit tunnel; 50S ribosomal protein L23 838479 rplW 4551536 rplW Mycobacterium ulcerans Agy99 50S ribosomal protein L23 YP_904905.1 838177 D 362242 CDS YP_904906.1 118616574 4551537 838509..839351 1 NC_008611.1 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation; 50S ribosomal protein L2 839351 rplB 4551537 rplB Mycobacterium ulcerans Agy99 50S ribosomal protein L2 YP_904906.1 838509 D 362242 CDS YP_904907.1 118616575 4551538 839373..839654 1 NC_008611.1 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA; 30S ribosomal protein S19 839654 rpsS 4551538 rpsS Mycobacterium ulcerans Agy99 30S ribosomal protein S19 YP_904907.1 839373 D 362242 CDS YP_904908.1 118616576 4551539 839683..840213 1 NC_008611.1 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center; 50S ribosomal protein L22 840213 rplV 4551539 rplV Mycobacterium ulcerans Agy99 50S ribosomal protein L22 YP_904908.1 839683 D 362242 CDS YP_904909.1 118616577 4551540 840213..841040 1 NC_008611.1 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation; 30S ribosomal protein S3 841040 rpsC 4551540 rpsC Mycobacterium ulcerans Agy99 30S ribosomal protein S3 YP_904909.1 840213 D 362242 CDS YP_904910.1 118616578 4551541 841044..841460 1 NC_008611.1 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e; 50S ribosomal protein L16 841460 rplP 4551541 rplP Mycobacterium ulcerans Agy99 50S ribosomal protein L16 YP_904910.1 841044 D 362242 CDS YP_904911.1 118616579 4551542 841460..841702 1 NC_008611.1 one of the stabilizing components for the large ribosomal subunit; 50S ribosomal protein L29 841702 rpmC 4551542 rpmC Mycobacterium ulcerans Agy99 50S ribosomal protein L29 YP_904911.1 841460 D 362242 CDS YP_904912.1 118616580 4551543 841699..842061 1 NC_008611.1 primary binding protein; helps mediate assembly; involved in translation fidelity; 30S ribosomal protein S17 842061 rpsQ 4551543 rpsQ Mycobacterium ulcerans Agy99 30S ribosomal protein S17 YP_904912.1 841699 D 362242 CDS YP_904913.1 118616581 4551338 844636..845247 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; hypothetical protein 845247 4551338 MUL_0801 Mycobacterium ulcerans Agy99 hypothetical protein YP_904913.1 844636 D 362242 CDS YP_904914.1 118616582 4551340 846265..847203 1 NC_008611.1 membrane protein; transmembrane protein 847203 4551340 MUL_0803 Mycobacterium ulcerans Agy99 transmembrane protein YP_904914.1 846265 D 362242 CDS YP_904915.1 118616583 4551341 847454..847822 1 NC_008611.1 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase; 50S ribosomal protein L14 847822 rplN 4551341 rplN Mycobacterium ulcerans Agy99 50S ribosomal protein L14 YP_904915.1 847454 D 362242 CDS YP_904916.1 118616584 4551342 847823..848146 1 NC_008611.1 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel; 50S ribosomal protein L24 848146 rplX 4551342 rplX Mycobacterium ulcerans Agy99 50S ribosomal protein L24 YP_904916.1 847823 D 362242 CDS YP_904917.1 118616585 4551343 848143..848715 1 NC_008611.1 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13; 50S ribosomal protein L5 848715 rplE 4551343 rplE Mycobacterium ulcerans Agy99 50S ribosomal protein L5 YP_904917.1 848143 D 362242 CDS YP_904918.1 118616586 4551344 848720..848905 1 NC_008611.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group appear to contain the zinc-binding motif; 30S ribosomal protein S14 848905 rpsN 4551344 rpsN Mycobacterium ulcerans Agy99 30S ribosomal protein S14 YP_904918.1 848720 D 362242 CDS YP_904919.1 118616587 4551345 848982..849380 1 NC_008611.1 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; 30S ribosomal protein S8 849380 rpsH 4551345 rpsH Mycobacterium ulcerans Agy99 30S ribosomal protein S8 YP_904919.1 848982 D 362242 CDS YP_904920.1 118616588 4551346 849391..849930 1 NC_008611.1 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance; 50S ribosomal protein L6 849930 rplF 4551346 rplF Mycobacterium ulcerans Agy99 50S ribosomal protein L6 YP_904920.1 849391 D 362242 CDS YP_904921.1 118616589 4551347 849972..850340 1 NC_008611.1 cytoplasmic protein; this is one of 3 proteins that mediate the attachment of the 5S RNA into the large ribosomal subunit.; 50S ribosomal protein L18, RplR 850340 rplR 4551347 rplR Mycobacterium ulcerans Agy99 50S ribosomal protein L18, RplR YP_904921.1 849972 D 362242 CDS YP_904922.1 118616590 4551348 850378..851052 1 NC_008611.1 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance; 30S ribosomal protein S5 851052 rpsE 4551348 rpsE Mycobacterium ulcerans Agy99 30S ribosomal protein S5 YP_904922.1 850378 D 362242 CDS YP_904923.1 118616591 4551349 851049..851267 1 NC_008611.1 L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7; 50S ribosomal protein L30 851267 rpmD 4551349 rpmD Mycobacterium ulcerans Agy99 50S ribosomal protein L30 YP_904923.1 851049 D 362242 CDS YP_904924.1 118616592 4551350 851264..851704 1 NC_008611.1 late assembly protein; 50S ribosomal protein L15 851704 rplO 4551350 rplO Mycobacterium ulcerans Agy99 50S ribosomal protein L15 YP_904924.1 851264 D 362242 CDS YP_904925.1 118616593 4551351 complement(851772..852698) 1 NC_008611.1 cytoplasmic protein; flavin-dependent oxidoreductase 852698 4551351 MUL_0814 Mycobacterium ulcerans Agy99 flavin-dependent oxidoreductase YP_904925.1 851772 R 362242 CDS YP_904926.1 118616594 4551352 852785..854587 1 NC_008611.1 membrane protein; involved in digestion of the cleaved signal peptides. this activity is necessary to maintain proper secretion of mature proteins across the membrane.; protease IV, Ssp 854587 ssp 4551352 ssp Mycobacterium ulcerans Agy99 protease IV, Ssp YP_904926.1 852785 D 362242 CDS YP_904927.1 118616595 4551353 complement(854584..855498) 1 NC_008611.1 cytoplasmic protein; O-methyltransferase 855498 4551353 MUL_0816 Mycobacterium ulcerans Agy99 O-methyltransferase YP_904927.1 854584 R 362242 CDS YP_904928.1 118616596 4551354 complement(855518..856420) 1 NC_008611.1 cytoplasmic protein; O-methyltransferase 856420 4551354 MUL_0817 Mycobacterium ulcerans Agy99 O-methyltransferase YP_904928.1 855518 R 362242 CDS YP_904929.1 118616597 4551355 complement(856417..857391) 1 NC_008611.1 cytoplasmic protein; O-methyltransferase 857391 4551355 MUL_0818 Mycobacterium ulcerans Agy99 O-methyltransferase YP_904929.1 856417 R 362242 CDS YP_904930.1 118616598 4551356 857608..859623 1 NC_008611.1 membrane protein; function unknown, may contain two dehyrogenase domains, first showing better similarity; short-chain dehydrogenase Adh_1 859623 adh_1 4551356 adh_1 Mycobacterium ulcerans Agy99 short-chain dehydrogenase Adh_1 YP_904930.1 857608 D 362242 CDS YP_904931.1 118616599 4551357 complement(859632..860312) 1 NC_008611.1 cytoplasmic protein; methyltransferase 860312 4551357 MUL_0820 Mycobacterium ulcerans Agy99 methyltransferase YP_904931.1 859632 R 362242 CDS YP_904932.1 118616600 4550173 860368..861246 1 NC_008611.1 cytoplasmic protein; involved in transcriptional mechanism.; transcriptional regulatory protein 861246 4550173 MUL_0821 Mycobacterium ulcerans Agy99 transcriptional regulatory protein YP_904932.1 860368 D 362242 CDS YP_904933.1 118616601 4550174 complement(861270..861926) 1 NC_008611.1 catalyzes the formation of glycerone phosphate and (S)-lactaldehyde from L-fuculose 1-phosphate; L-fuculose-phosphate aldolase 861926 fucA 4550174 fucA Mycobacterium ulcerans Agy99 L-fuculose-phosphate aldolase YP_904933.1 861270 R 362242 CDS YP_904934.1 118616602 4550175 complement(861923..862912) 1 NC_008611.1 cytoplasmic protein; involved at the first committed step in the 'phosphorylated' pathway of L-serine biosynthesis. catalyzes the oxidation of D-3-phosphoglycerate to 3- phosphohydroxypyruvate [catalytic activity: 3- phosphoglycerate + NAD(+) = 3-phosphohydroxypyruvate + NADH]; D-3-phosphoglycerate dehydrogenase SerA2 862912 serA2 4550175 serA2 Mycobacterium ulcerans Agy99 D-3-phosphoglycerate dehydrogenase SerA2 YP_904934.1 861923 R 362242 CDS YP_904935.1 118616603 4550176 862943..864178 1 NC_008611.1 membrane protein; phosphorylates D-xylulose [catalytic activity: ATP + D-xylulose = ADP + D-xylulose 5-phosphate]; D-xylulose-kinase (xylulokinase), XylB 864178 xylB 4550176 xylB Mycobacterium ulcerans Agy99 D-xylulose-kinase (xylulokinase), XylB YP_904935.1 862943 D 362242 CDS YP_904936.1 118616604 4550177 864386..865114 1 NC_008611.1 Detected in the cytoplasmic and membrane fractions by LC-MS/MS. Also detected in the extracellular matrix by proteomics.; cytoplasmic protein; hypothetical protein 865114 4550177 MUL_0825 Mycobacterium ulcerans Agy99 hypothetical protein YP_904936.1 864386 D 362242 CDS YP_904937.1 118616605 4550180 867306..868631 1 NC_008611.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase; preprotein translocase subunit SecY 868631 secY 4550180 secY Mycobacterium ulcerans Agy99 preprotein translocase subunit SecY YP_904937.1 867306 D 362242 CDS YP_904938.1 118616606 4550181 868628..869173 1 NC_008611.1 essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP; adenylate kinase 869173 adk 4550181 adk Mycobacterium ulcerans Agy99 adenylate kinase YP_904938.1 868628 D 362242 CDS YP_904939.1 118616607 4550182 869176..869976 1 NC_008611.1 catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn; methionine aminopeptidase 869976 mapA 4550182 mapA Mycobacterium ulcerans Agy99 methionine aminopeptidase YP_904939.1 869176 D 362242 CDS YP_904940.1 118616608 4550183 870029..870562 1 NC_008611.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; in M. tuberculosis this protein regulates polyketide synthases and secreted or membrane proteins; RNA polymerase sigma factor SigL 870562 sigL 4550183 sigL Mycobacterium ulcerans Agy99 RNA polymerase sigma factor SigL YP_904940.1 870029 D 362242 CDS YP_904941.1 118616609 4550184 870641..871387 1 NC_008611.1 membrane protein; function unknown, domain identity suggests possible role in transcription regulation; hypothetical protein 871387 4550184 MUL_0832 Mycobacterium ulcerans Agy99 hypothetical protein YP_904941.1 870641 D 362242 CDS YP_904942.1 118616610 4550185 871474..871974 1 NC_008611.1 cytoplasmic protein; involved in transcriptional mechanism.; transcriptional regulator 871974 4550185 MUL_0833 Mycobacterium ulcerans Agy99 transcriptional regulator YP_904942.1 871474 D 362242 CDS YP_904943.1 118616611 4550186 871998..872546 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; hypothetical protein 872546 4550186 MUL_0834 Mycobacterium ulcerans Agy99 hypothetical protein YP_904943.1 871998 D 362242 CDS YP_904944.1 118616612 4550187 complement(872559..873443) 1 NC_008611.1 membrane protein; catalyzes the NAD-dependent, reversible oxidation of 3-hydroxbutyrate to methylmalonate [catalytic activity: 3-hydroxy-2-methylpropanoate + NAD+ = 2-methyl-3- oxopropanoate + NADH]; 3-hydroxyisobutyrate dehydrogenase, MmsB 873443 mmsB 4550187 mmsB Mycobacterium ulcerans Agy99 3-hydroxyisobutyrate dehydrogenase, MmsB YP_904944.1 872559 R 362242 CDS YP_904945.1 118616613 4550188 complement(873456..874628) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; lipid metabolism; acyl-CoA dehydrogenase, FadE9 874628 fadE9 4550188 fadE9 Mycobacterium ulcerans Agy99 acyl-CoA dehydrogenase, FadE9 YP_904945.1 873456 R 362242 CDS YP_904946.1 118616614 4550189 complement(874634..876154) 1 NC_008611.1 Detected in the cytoplamic fraction by LCMSMS. Also detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; plays a role in valine and pyrimidine metabolism. binds fatty acyl-CoA [catalytic activity: 2-methyl-3- oxopropanoate + CoA + NAD+ = propanoyl-CoA + CO2 + NADH]; methylmalonate semialdehyde dehydrogenase, MmsA 876154 mmsA 4550189 mmsA Mycobacterium ulcerans Agy99 methylmalonate semialdehyde dehydrogenase, MmsA YP_904946.1 874634 R 362242 CDS YP_904947.1 118616615 4550190 complement(876334..877914) 1 NC_008611.1 membrane protein; transmembrane carbohydrate transport protein 877914 4550190 MUL_0838 Mycobacterium ulcerans Agy99 transmembrane carbohydrate transport protein YP_904947.1 876334 R 362242 CDS YP_904948.1 118616616 4550191 complement(878058..878663) 1 NC_008611.1 cytoplasmic protein; involved in dTDP-L-rhamnose biosynthesis, within the O antigen biosynthesis pathway of lipopolysaccharide biosynthesis: conversion of dTDP-4-keto-6-deoxy-D-glucose to dTDP-4-keto-rhamnose [catalytic activity: dTDP-4- dehydro-6-deoxy-D-glucose = dTDP-4-dehydro-6-deoxy-L- mannose]; dTDP-4-dehydrorhamnose 3,5-epimerase, RmlC 878663 rmlC 4550191 rmlC Mycobacterium ulcerans Agy99 dTDP-4-dehydrorhamnose 3,5-epimerase, RmlC YP_904948.1 878058 R 362242 CDS YP_904949.1 118616617 4553550 complement(878665..879660) 1 NC_008611.1 cytoplasmic protein; involved in dTDP-L-rhamnose biosynthesis [catalytic activity: dTDP-glucose = DTDP-4-dehydro-6-deoxy-D-glucose + H(2)O]; dTDP-glucose-4,6-dehydratase, RmlB 879660 rmlB 4553550 rmlB Mycobacterium ulcerans Agy99 dTDP-glucose-4,6-dehydratase, RmlB YP_904949.1 878665 R 362242 CDS YP_904950.1 118616618 4553551 complement(879670..880530) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 880530 4553551 MUL_0841 Mycobacterium ulcerans Agy99 hypothetical protein YP_904950.1 879670 R 362242 CDS YP_904951.1 118616619 4553552 complement(880557..881453) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 881453 4553552 MUL_0842 Mycobacterium ulcerans Agy99 hypothetical protein YP_904951.1 880557 R 362242 CDS YP_904952.1 118616620 4553553 881701..881922 1 NC_008611.1 stimulates the activities of the other two initiation factors, IF-2 and IF-3; translation initiation factor IF-1 881922 infA 4553553 infA Mycobacterium ulcerans Agy99 translation initiation factor IF-1 YP_904952.1 881701 D 362242 CDS YP_904953.1 118616621 4553554 881956..882069 1 NC_008611.1 smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif; 50S ribosomal protein L36 882069 rpmJ 4553554 rpmJ Mycobacterium ulcerans Agy99 50S ribosomal protein L36 YP_904953.1 881956 D 362242 CDS YP_904954.1 118616622 4553555 882260..882634 1 NC_008611.1 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA; 30S ribosomal protein S13 882634 rpsM 4553555 rpsM Mycobacterium ulcerans Agy99 30S ribosomal protein S13 YP_904954.1 882260 D 362242 CDS YP_904955.1 118616623 4553556 882638..883054 1 NC_008611.1 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3; 30S ribosomal protein S11 883054 rpsK 4553556 rpsK Mycobacterium ulcerans Agy99 30S ribosomal protein S11 YP_904955.1 882638 D 362242 CDS YP_904956.1 118616624 4553557 883073..883678 1 NC_008611.1 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination; 30S ribosomal protein S4 883678 rpsD 4553557 rpsD Mycobacterium ulcerans Agy99 30S ribosomal protein S4 YP_904956.1 883073 D 362242 CDS YP_904957.1 118616625 4553558 883764..884807 1 NC_008611.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme; DNA-directed RNA polymerase subunit alpha 884807 rpoA 4553558 rpoA Mycobacterium ulcerans Agy99 DNA-directed RNA polymerase subunit alpha YP_904957.1 883764 D 362242 CDS YP_904958.1 118616626 4553559 884868..885437 1 NC_008611.1 is a component of the macrolide binding site in the peptidyl transferase center; 50S ribosomal protein L17 885437 rplQ 4553559 rplQ Mycobacterium ulcerans Agy99 50S ribosomal protein L17 YP_904958.1 884868 D 362242 CDS YP_904959.1 118616627 4553560 885499..886281 1 NC_008611.1 mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability; tRNA pseudouridine synthase A 886281 truA 4553560 truA Mycobacterium ulcerans Agy99 tRNA pseudouridine synthase A YP_904959.1 885499 D 362242 CDS YP_904960.1 118616628 4553561 complement(886297..887787) 1 NC_008611.1 membrane protein; permease that is involved in the transport across the cytoplasmic membrane of D-alanine, D-serine and glycine; D-serine/D-alanine/glycine transporter, CycA 887787 cycA 4553561 cycA Mycobacterium ulcerans Agy99 D-serine/D-alanine/glycine transporter, CycA YP_904960.1 886297 R 362242 CDS YP_904961.1 118616629 4553562 complement(888055..889197) 1 NC_008611.1 membrane protein; PPE family protein 889197 4553562 MUL_5078 Mycobacterium ulcerans Agy99 PPE family protein YP_904961.1 888055 R 362242 CDS YP_904962.1 118616630 4553565 complement(892507..893202) 1 NC_008611.1 membrane protein; hydrolysis of cutin (a polyester that forms the structure of plant cuticle); cutinase precursor, Cut4 893202 cut4 4553565 cut4 Mycobacterium ulcerans Agy99 cutinase precursor, Cut4 YP_904962.1 892507 R 362242 CDS YP_904963.1 118616631 4553566 complement(893234..894037) 1 NC_008611.1 membrane protein; cutinase precursor, Cut3 894037 cut3 4553566 cut3 Mycobacterium ulcerans Agy99 cutinase precursor, Cut3 YP_904963.1 893234 R 362242 CDS YP_904964.1 118616632 4553567 894150..895658 1 NC_008611.1 membrane protein; hypothetical protein 895658 4553567 MUL_0857 Mycobacterium ulcerans Agy99 hypothetical protein YP_904964.1 894150 D 362242 CDS YP_904965.1 118616633 4553568 complement(895548..896921) 1 NC_008611.1 membrane protein; membrane-anchored serine protease (mycosin), MycP4 896921 mycP4 4553568 mycP4 Mycobacterium ulcerans Agy99 membrane-anchored serine protease (mycosin), MycP4 YP_904965.1 895548 R 362242 CDS YP_904966.1 118616634 4553765 complement(896918..898300) 1 NC_008611.1 membrane protein; hypothetical protein 898300 4553765 MUL_0859 Mycobacterium ulcerans Agy99 hypothetical protein YP_904966.1 896918 R 362242 CDS YP_904967.1 118616635 4553766 898415..902095 1 NC_008611.1 membrane protein; function unknown but has 3 ATP binding P-loop motifs; hypothetical protein 902095 4553766 MUL_0860 Mycobacterium ulcerans Agy99 hypothetical protein YP_904967.1 898415 D 362242 CDS YP_904968.1 118616636 4553767 902092..903336 1 NC_008611.1 membrane protein; hypothetical protein 903336 4553767 MUL_0861 Mycobacterium ulcerans Agy99 hypothetical protein YP_904968.1 902092 D 362242 CDS YP_904969.1 118616637 4553768 903399..903752 1 NC_008611.1 secreted protein; EsaT-6 like protein, EsxU 903752 esxU 4553768 esxU Mycobacterium ulcerans Agy99 EsaT-6 like protein, EsxU YP_904969.1 903399 D 362242 CDS YP_904970.1 118616638 4553769 903768..904064 1 NC_008611.1 secreted protein; EsaT-6 like protein, EsxT 904064 esxT 4553769 esxT Mycobacterium ulcerans Agy99 EsaT-6 like protein, EsxT YP_904970.1 903768 D 362242 CDS YP_904971.1 118616639 4553770 904303..904746 1 NC_008611.1 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit; 50S ribosomal protein L13 904746 rplM 4553770 rplM Mycobacterium ulcerans Agy99 50S ribosomal protein L13 YP_904971.1 904303 D 362242 CDS YP_904972.1 118616640 4553771 904743..905201 1 NC_008611.1 forms a direct contact with the tRNA during translation; 30S ribosomal protein S9 905201 rpsI 4553771 rpsI Mycobacterium ulcerans Agy99 30S ribosomal protein S9 YP_904972.1 904743 D 362242 CDS YP_904973.1 118616641 4553772 905352..906689 1 NC_008611.1 catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; phosphoglucosamine mutase 906689 glmM 4553772 glmM Mycobacterium ulcerans Agy99 phosphoglucosamine mutase YP_904973.1 905352 D 362242 CDS YP_904974.1 118616642 4553773 906794..907105 1 NC_008611.1 cytoplasmic protein; hypothetical protein 907105 4553773 MUL_0867 Mycobacterium ulcerans Agy99 hypothetical protein YP_904974.1 906794 D 362242 CDS YP_904975.1 118616643 4553774 907108..908505 1 NC_008611.1 cytoplasmic protein; hypothetical protein 908505 4553774 MUL_0868 Mycobacterium ulcerans Agy99 hypothetical protein YP_904975.1 907108 D 362242 CDS YP_904976.1 118616644 4553776 complement(909590..910429) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); cytoplasmic protein; hydrolase domain identity; hypothetical protein 910429 4553776 MUL_0870 Mycobacterium ulcerans Agy99 hypothetical protein YP_904976.1 909590 R 362242 CDS YP_904977.1 118616645 4553778 911022..912899 1 NC_008611.1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source; glucosamine--fructose-6-phosphate aminotransferase 912899 glmS 4553778 glmS Mycobacterium ulcerans Agy99 glucosamine--fructose-6-phosphate aminotransferase YP_904977.1 911022 D 362242 CDS YP_904978.1 118616646 4553780 complement(913561..914607) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 914607 4553780 MUL_0874 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_904978.1 913561 R 362242 CDS YP_904979.1 118616647 4553781 915234..915947 1 NC_008611.1 hypothetical protein 915947 4553781 MUL_0876 Mycobacterium ulcerans Agy99 hypothetical protein YP_904979.1 915234 D 362242 CDS YP_904980.1 118616648 4553782 915978..917399 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; has domain identity with YjeF-related protein N- terminus and sugar kinases c-terminus; transmembrane protein 917399 4553782 MUL_0877 Mycobacterium ulcerans Agy99 transmembrane protein YP_904980.1 915978 D 362242 CDS YP_904981.1 118616649 4553783 917436..918821 1 NC_008611.1 cytoplasmic protein; catalyzes the production of GabA [catalytic activity: L-glutamate = 4-aminobutanoate + CO(2)]; glutamate decarboxylase, GadB 918821 gadB 4553783 gadB Mycobacterium ulcerans Agy99 glutamate decarboxylase, GadB YP_904981.1 917436 D 362242 CDS YP_904982.1 118616650 4550853 918908..920074 1 NC_008611.1 converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer; alanine racemase 920074 alr 4550853 alr Mycobacterium ulcerans Agy99 alanine racemase YP_904982.1 918908 D 362242 CDS YP_904983.1 118616651 4550854 920064..921185 1 NC_008611.1 secreted protein; hydrolase 921185 4550854 MUL_0880 Mycobacterium ulcerans Agy99 hydrolase YP_904983.1 920064 D 362242 CDS YP_904984.1 118616652 4550855 921178..921648 1 NC_008611.1 cytoplasmic protein; ATPase domain; hypothetical protein 921648 4550855 MUL_0881 Mycobacterium ulcerans Agy99 hypothetical protein YP_904984.1 921178 D 362242 CDS YP_904985.1 118616653 4550856 921645..922271 1 NC_008611.1 membrane protein; peptidase; hypothetical protein 922271 4550856 MUL_0882 Mycobacterium ulcerans Agy99 hypothetical protein YP_904985.1 921645 D 362242 CDS YP_904986.1 118616654 4550857 922268..922744 1 NC_008611.1 cytoplasmic protein; this enzyme acetylates the N-terminal alanine of ribosomal protein S18 [catalytic activity: acetyl-CoA + ribosomal-protein L-alanine = CoA + ribosomal-protein N- acetyl-L-alanine]; ribosomal-protein-alanine acetyltransferase, RimI 922744 rimI 4550857 rimI Mycobacterium ulcerans Agy99 ribosomal-protein-alanine acetyltransferase, RimI YP_904986.1 922268 D 362242 CDS YP_904987.1 118616655 4550858 922745..923776 1 NC_008611.1 in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity; putative DNA-binding/iron metalloprotein/AP endonuclease 923776 gcp 4550858 gcp Mycobacterium ulcerans Agy99 putative DNA-binding/iron metalloprotein/AP endonuclease YP_904987.1 922745 D 362242 CDS YP_904988.1 118616656 4550859 924090..924392 1 NC_008611.1 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring; co-chaperonin GroES 924392 groES 4550859 groES Mycobacterium ulcerans Agy99 co-chaperonin GroES YP_904988.1 924090 D 362242 CDS YP_904989.1 118616657 4550860 924485..926104 1 NC_008611.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is not essential for growth; chaperonin GroEL 926104 groEL 4550860 groEL Mycobacterium ulcerans Agy99 chaperonin GroEL YP_904989.1 924485 D 362242 CDS YP_904990.1 118616658 4550862 complement(927247..928293) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 928293 4550862 MUL_0888 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_904990.1 927247 R 362242 CDS YP_904991.1 118616659 4550863 complement(928988..929425) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 929425 4550863 MUL_0889 Mycobacterium ulcerans Agy99 hypothetical protein YP_904991.1 928988 R 362242 CDS YP_904992.1 118616660 4550864 complement(929692..931407) 1 NC_008611.1 membrane protein; PPE family protein 931407 4550864 MUL_0890 Mycobacterium ulcerans Agy99 PPE family protein YP_904992.1 929692 R 362242 CDS YP_904993.1 118616661 4550865 931450..931977 1 NC_008611.1 cytoplasmic protein; hypothetical protein 931977 4550865 MUL_0891 Mycobacterium ulcerans Agy99 hypothetical protein YP_904993.1 931450 D 362242 CDS YP_904994.1 118616662 4550867 933955..935610 1 NC_008611.1 cytoplasmic protein; metal-dependent hydrolase 935610 4550867 MUL_0894 Mycobacterium ulcerans Agy99 metal-dependent hydrolase YP_904994.1 933955 D 362242 CDS YP_904995.1 118616663 4550868 complement(935655..935963) 1 NC_008611.1 cytoplasmic protein; involved in transcriptional mechanism (growth phase- dependent); Whib-like regulatory protein, WhiB3 935963 whiB3 4550868 whiB3 Mycobacterium ulcerans Agy99 Whib-like regulatory protein, WhiB3 YP_904995.1 935655 R 362242 CDS YP_904996.1 118616664 4550869 936474..937520 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 937520 4550869 MUL_0896 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_904996.1 936474 D 362242 CDS YP_904997.1 118616665 4550780 937567..938160 1 NC_008611.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this protein is involved in expression of ribosome-associated gene products in stationary phase; RNA polymerase sigma factor SigD 938160 sigD 4550780 sigD Mycobacterium ulcerans Agy99 RNA polymerase sigma factor SigD YP_904997.1 937567 D 362242 CDS YP_904998.1 118616666 4550781 938153..939199 1 NC_008611.1 cytoplasmic protein; hypothetical protein 939199 4550781 MUL_0898 Mycobacterium ulcerans Agy99 hypothetical protein YP_904998.1 938153 D 362242 CDS YP_904999.1 118616667 4550782 complement(939260..939673) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 939673 4550782 MUL_0899 Mycobacterium ulcerans Agy99 hypothetical protein YP_904999.1 939260 R 362242 CDS YP_905000.1 118616668 4550783 939837..941435 1 NC_008611.1 catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; inosine 5'-monophosphate dehydrogenase 941435 guaB2 4550783 guaB2 Mycobacterium ulcerans Agy99 inosine 5'-monophosphate dehydrogenase YP_905000.1 939837 D 362242 CDS YP_905001.1 118616669 4550784 941445..942572 1 NC_008611.1 catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; inosine 5-monophosphate dehydrogenase 942572 guaB3 4550784 guaB3 Mycobacterium ulcerans Agy99 inosine 5-monophosphate dehydrogenase YP_905001.1 941445 D 362242 CDS YP_905002.1 118616670 4550785 942753..944579 1 NC_008611.1 membrane protein; PPE family protein 944579 4550785 MUL_0902 Mycobacterium ulcerans Agy99 PPE family protein YP_905002.1 942753 D 362242 CDS YP_905003.1 118616671 4550786 944668..946413 1 NC_008611.1 membrane protein; involved in cholesterol metabolism [catalytic activity: cholesterol + O(2) = cholest-4-en-3-one + H(2)O(2)]; cholesterol oxidase precursor ChoD 946413 choD 4550786 choD Mycobacterium ulcerans Agy99 cholesterol oxidase precursor ChoD YP_905003.1 944668 D 362242 CDS YP_905004.1 118616672 4550787 complement(946439..947335) 1 NC_008611.1 cytoplasmic protein; in E. coli this enzyme catalyses the oxygenolytic release of sulfite from taurine.; taurine catabolism dioxygenase, TauD 947335 tauD 4550787 tauD Mycobacterium ulcerans Agy99 taurine catabolism dioxygenase, TauD YP_905004.1 946439 R 362242 CDS YP_905005.1 118616673 4550788 947396..947971 1 NC_008611.1 cytoplasmic protein; involved in transcriptional mechanism.; transcriptional regulator 947971 4550788 MUL_0905 Mycobacterium ulcerans Agy99 transcriptional regulator YP_905005.1 947396 D 362242 CDS YP_905006.1 118616674 4550789 complement(947957..949873) 1 NC_008611.1 cytoplasmic protein; similar to maltose phosphorylase, a dimeric enzyme that catalyses the conversion of maltose and inorganic phosphate into beta-D-glucose-1-phosphate and glucose; glycosyl hydrolase 949873 4550789 MUL_0906 Mycobacterium ulcerans Agy99 glycosyl hydrolase YP_905006.1 947957 R 362242 CDS YP_905007.1 118616675 4550790 950296..951342 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 951342 4550790 MUL_0907 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_905007.1 950296 D 362242 CDS YP_905008.1 118616676 4550791 complement(951308..951865) 1 NC_008611.1 cytoplasmic protein; cellular metabolism; hydrolase 951865 4550791 MUL_0908 Mycobacterium ulcerans Agy99 hydrolase YP_905008.1 951308 R 362242 CDS YP_905009.1 118616677 4550792 951947..952465 1 NC_008611.1 cytoplasmic protein; hypothetical protein 952465 4550792 MUL_0909 Mycobacterium ulcerans Agy99 hypothetical protein YP_905009.1 951947 D 362242 CDS YP_905010.1 118616678 4550793 952504..953121 1 NC_008611.1 cytoplasmic protein; involved in transcriptional mechanism.; transcriptional regulatory protein 953121 4550793 MUL_0910 Mycobacterium ulcerans Agy99 transcriptional regulatory protein YP_905010.1 952504 D 362242 CDS YP_905011.1 118616679 4550794 complement(953118..954674) 1 NC_008611.1 Detected in the membrane fraction by proteomics (2D- LC-MS/MS) Also detected in the cytoplasmic fraction by 2D- LC-MS/MS.; membrane protein; integral membrane transport protein 954674 4550794 MUL_0911 Mycobacterium ulcerans Agy99 integral membrane transport protein YP_905011.1 953118 R 362242 CDS YP_905012.1 118616680 4550795 954753..955436 1 NC_008611.1 cytoplasmic protein; involved in transcriptional mechanism.; transcriptional regulatory protein 955436 4550795 MUL_0912 Mycobacterium ulcerans Agy99 transcriptional regulatory protein YP_905012.1 954753 D 362242 CDS YP_905013.1 118616681 4550796 955509..957092 1 NC_008611.1 contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway; GMP synthase 957092 guaA 4550796 guaA Mycobacterium ulcerans Agy99 GMP synthase YP_905013.1 955509 D 362242 CDS YP_905014.1 118616682 4550797 complement(957160..957849) 1 NC_008611.1 secreted protein; hypothetical protein 957849 4550797 MUL_0914 Mycobacterium ulcerans Agy99 hypothetical protein YP_905014.1 957160 R 362242 CDS YP_905015.1 118616683 4550798 957923..958615 1 NC_008611.1 cytoplasmic protein; hypothetical protein 958615 4550798 MUL_0915 Mycobacterium ulcerans Agy99 hypothetical protein YP_905015.1 957923 D 362242 CDS YP_905016.1 118616684 4551638 958622..960193 1 NC_008611.1 secreted protein; function unknown but belongs to the DNA/RNA polymerase superfamily; hypothetical protein 960193 4551638 MUL_0916 Mycobacterium ulcerans Agy99 hypothetical protein YP_905016.1 958622 D 362242 CDS YP_905017.1 118616685 4551640 complement(961261..963273) 1 NC_008611.1 cytoplasmic protein; multi functional protein with fatty acyl-CoA reductase activity in C-terminal part; short chain dehydrogenase 963273 acrA1 4551640 acrA1 Mycobacterium ulcerans Agy99 short chain dehydrogenase YP_905017.1 961261 R 362242 CDS YP_905018.1 118616686 4551641 complement(963313..964026) 1 NC_008611.1 membrane protein; lipoprotein, LpqD 964026 lpqD 4551641 lpqD Mycobacterium ulcerans Agy99 lipoprotein, LpqD YP_905018.1 963313 R 362242 CDS YP_905019.1 118616687 4551642 964122..964994 1 NC_008611.1 Also detected as secreted protein; cytoplasmic protein; may have dehydratase activity; contains a MaoC protein family domain; hypothetical protein 964994 4551642 MUL_0920 Mycobacterium ulcerans Agy99 hypothetical protein YP_905019.1 964122 D 362242 CDS YP_905020.1 118616688 4551643 complement(965008..966180) 1 NC_008611.1 cytoplasmic protein; involved in osmoregulatory trehalose biosynthesis. mycobacteria can produce trehalose from glucose 6- phosphate and UDP-glucose (the OtsA-OtsB pathway) from glycogen-like alpha(1-->4)-linked glucose polymers (the TreY-TreZ pathway) and from maltose (the TreS pathway) [catalytic activity: trehalose 6-phosphate + H(2)O = trehalose + orthophosphate]; trehalose-6-phosphate phosphatase OtsB2 966180 otsB2 4551643 otsB2 Mycobacterium ulcerans Agy99 trehalose-6-phosphate phosphatase OtsB2 YP_905020.1 965008 R 362242 CDS YP_905021.1 118616689 4551645 967815..971081 1 NC_008611.1 DNA polymerase involved in damage-induced mutagenesis and translesion synthesis. It is not the major replicative DNA polymerase.; error-prone DNA polymerase 971081 dnaE2 4551645 dnaE2 Mycobacterium ulcerans Agy99 error-prone DNA polymerase YP_905021.1 967815 D 362242 CDS YP_905022.1 118616690 4551648 972061..973107 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 973107 4551648 MUL_0925 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_905022.1 972061 D 362242 CDS YP_905023.1 118616691 4551649 complement(973244..974167) 1 NC_008611.1 membrane protein; hypothetical protein 974167 4551649 MUL_0926 Mycobacterium ulcerans Agy99 hypothetical protein YP_905023.1 973244 R 362242 CDS YP_905024.1 118616692 4551650 complement(974498..976018) 1 NC_008611.1 membrane protein; involved in secretion of nitrite produced by the dissimilatory reduction of nitrate. responsible for the translocation of the substrate across the membrane.; nitrite extrusion protein, NarK3_3 976018 narK3_3 4551650 narK3_3 Mycobacterium ulcerans Agy99 nitrite extrusion protein, NarK3_3 YP_905024.1 974498 R 362242 CDS YP_905025.1 118616693 4551651 complement(975996..976418) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 976418 4551651 MUL_0928 Mycobacterium ulcerans Agy99 hypothetical protein YP_905025.1 975996 R 362242 CDS YP_905026.1 118616694 4551652 complement(976518..976730) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 976730 4551652 MUL_0929 Mycobacterium ulcerans Agy99 hypothetical protein YP_905026.1 976518 R 362242 CDS YP_905027.1 118616695 4551654 complement(977672..979270) 1 NC_008611.1 cytoplasmic protein; may be a regulatory protein; hypothetical protein 979270 4551654 MUL_0931 Mycobacterium ulcerans Agy99 hypothetical protein YP_905027.1 977672 R 362242 CDS YP_905028.1 118616696 4551655 979304..980986 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); cytoplasmic protein; involved in the arginase pathway [catalytic activity: 1-pyrroline-5-carboxylate + NAD(+) + H(2)O = L- glutamate + NADH]; pyrroline-5-carboxylate dehydrogenase, RocA 980986 rocA 4551655 rocA Mycobacterium ulcerans Agy99 pyrroline-5-carboxylate dehydrogenase, RocA YP_905028.1 979304 D 362242 CDS YP_905029.1 118616697 4552184 980986..981945 1 NC_008611.1 cytoplasmic protein; oxidizes proline to glutamate for use as a carbon and nitrogen source [catalytic activity: L-proline + acceptor + H2O = (S)-1-pyrroline-5-carboxylate + reduced acceptor]; proline dehydrogenase, PutA 981945 putA 4552184 putA Mycobacterium ulcerans Agy99 proline dehydrogenase, PutA YP_905029.1 980986 D 362242 CDS YP_905030.1 118616698 4552185 complement(981972..982625) 1 NC_008611.1 cytoplasmic protein; involved in transcriptional mechanism.; transcriptional regulator 982625 4552185 MUL_0934 Mycobacterium ulcerans Agy99 transcriptional regulator YP_905030.1 981972 R 362242 CDS YP_905031.1 118616699 4552186 complement(982609..983778) 1 NC_008611.1 membrane protein; lipid-transfer protein; lipid-transfer protein 983778 ltp2 4552186 ltp2 Mycobacterium ulcerans Agy99 lipid-transfer protein YP_905031.1 982609 R 362242 CDS YP_905032.1 118616700 4552187 complement(983775..984230) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 984230 4552187 MUL_0936 Mycobacterium ulcerans Agy99 hypothetical protein YP_905032.1 983775 R 362242 CDS YP_905033.1 118616701 4552188 complement(984227..984655) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 984655 4552188 MUL_0937 Mycobacterium ulcerans Agy99 hypothetical protein YP_905033.1 984227 R 362242 CDS YP_905034.1 118616702 4552189 complement(984655..985320) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 985320 4552189 MUL_0938 Mycobacterium ulcerans Agy99 hypothetical protein YP_905034.1 984655 R 362242 CDS YP_905035.1 118616703 4552190 985483..986949 1 NC_008611.1 cytoplasmic protein; oxidizes a variety of aldehydes [catalytic activity: an aldehyde + NAD+ + H2O = an acid + NADH]; NAD-dependent aldehyde dehydrogenase, AldA_1 986949 aldA_1 4552190 aldA_1 Mycobacterium ulcerans Agy99 NAD-dependent aldehyde dehydrogenase, AldA_1 YP_905035.1 985483 D 362242 CDS YP_905036.1 118616704 4552192 988063..988866 1 NC_008611.1 cytoplasmic protein; hypothetical protein 988866 4552192 MUL_0942 Mycobacterium ulcerans Agy99 hypothetical protein YP_905036.1 988063 D 362242 CDS YP_905037.1 118616705 4552193 988911..990329 1 NC_008611.1 activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 990329 fadD36 4552193 fadD36 Mycobacterium ulcerans Agy99 acyl-CoA synthetase YP_905037.1 988911 D 362242 CDS YP_905038.1 118616706 4552194 complement(990332..991597) 1 NC_008611.1 cytoplasmic protein; involved in transcriptional mechanism.; transcriptional regulatory protein 991597 4552194 MUL_0944 Mycobacterium ulcerans Agy99 transcriptional regulatory protein YP_905038.1 990332 R 362242 CDS YP_905039.1 118616707 4552195 992344..992643 1 NC_008611.1 PE31; membrane protein; PPE family protein 992643 4552195 MUL_0946 Mycobacterium ulcerans Agy99 PPE family protein YP_905039.1 992344 D 362242 CDS YP_905040.1 118616708 4552196 992683..993864 1 NC_008611.1 PPE18; membrane protein; PPE family protein 993864 4552196 MUL_0947 Mycobacterium ulcerans Agy99 PPE family protein YP_905040.1 992683 D 362242 CDS YP_905041.1 118616709 4552197 complement(994021..994683) 1 NC_008611.1 hypothetical protein 994683 4552197 MUL_0948 Mycobacterium ulcerans Agy99 hypothetical protein YP_905041.1 994021 R 362242 CDS YP_905042.1 118616710 4552198 995097..996380 1 NC_008611.1 membrane protein; integral membrane transport protein 996380 4552198 MUL_0949 Mycobacterium ulcerans Agy99 integral membrane transport protein YP_905042.1 995097 D 362242 CDS YP_905043.1 118616711 4552199 997038..998090 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 998090 4552199 MUL_0950 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_905043.1 997038 D 362242 CDS YP_905044.1 118616712 4552200 complement(998130..998492) 1 NC_008611.1 membrane protein; hypothetical protein 998492 4552200 MUL_0951 Mycobacterium ulcerans Agy99 hypothetical protein YP_905044.1 998130 R 362242 CDS YP_905045.1 118616713 4552201 998647..999147 1 NC_008611.1 cytoplasmic protein; putative regulatory protein 999147 4552201 MUL_0952 Mycobacterium ulcerans Agy99 putative regulatory protein YP_905045.1 998647 D 362242 CDS YP_905046.1 118616714 4552202 complement(999202..1000146) 1 NC_008611.1 Detected in the membrane fraction by proteomics.; membrane protein; function unknown, probably involved in cellular metabolism; transferase 1000146 4552202 MUL_0953 Mycobacterium ulcerans Agy99 transferase YP_905046.1 999202 R 362242 CDS YP_905047.1 118616715 4552203 1000269..1001333 1 NC_008611.1 catalyzes the formation of succinate and diaminoheptanedioate from succinyldiaminoheptanedioate; succinyl-diaminopimelate desuccinylase 1001333 dapE 4552203 dapE Mycobacterium ulcerans Agy99 succinyl-diaminopimelate desuccinylase YP_905047.1 1000269 D 362242 CDS YP_905048.1 118616716 4552204 complement(1001361..1003466) 1 NC_008611.1 membrane protein; hypothetical protein 1003466 4552204 MUL_0955 Mycobacterium ulcerans Agy99 hypothetical protein YP_905048.1 1001361 R 362242 CDS YP_905049.1 118616717 4552205 1003593..1004156 1 NC_008611.1 cytoplasmic protein; hypothetical protein 1004156 4552205 MUL_0956 Mycobacterium ulcerans Agy99 hypothetical protein YP_905049.1 1003593 D 362242 CDS YP_905050.1 118616718 4552206 1004227..1006008 1 NC_008611.1 activates fatty acids by binding to coenzyme A; may be involved in acyclic terpene utilization; long-chain-acyl-CoA synthetase 1006008 fadD6 4552206 fadD6 Mycobacterium ulcerans Agy99 long-chain-acyl-CoA synthetase YP_905050.1 1004227 D 362242 CDS YP_905051.1 118616719 4552207 1006098..1006973 1 NC_008611.1 involved in dihydrofolate biosynthesis [catalytic activity : 2-amino-4-hydroxy-6-hydroxymethyl-7,8- dihydropteridine diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate]; dihydropteroate synthase 2 FolP2 1006973 folP2 4552207 folP2 Mycobacterium ulcerans Agy99 dihydropteroate synthase 2 FolP2 YP_905051.1 1006098 D 362242 CDS YP_905052.1 118616720 4552208 1006970..1007953 1 NC_008611.1 cytoplasmic protein; putative glucosyl-3-phosphoglycerate synthase 1007953 4552208 MUL_0959 Mycobacterium ulcerans Agy99 putative glucosyl-3-phosphoglycerate synthase YP_905052.1 1006970 D 362242 CDS YP_905053.1 118616721 4552209 1008002..1008373 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); secreted protein; hypothetical protein 1008373 4552209 MUL_0960 Mycobacterium ulcerans Agy99 hypothetical protein YP_905053.1 1008002 D 362242 CDS YP_905054.1 118616722 4552210 1008370..1008948 1 NC_008611.1 cytoplasmic protein; involved in base excision repair. hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine from the damaged DNA polymer formed by alkylation lesions; DNA-3-methyladenine glycosylase I TagA 1008948 tagA 4552210 tagA Mycobacterium ulcerans Agy99 DNA-3-methyladenine glycosylase I TagA YP_905054.1 1008370 D 362242 CDS YP_905055.1 118616723 4552211 1009053..1009280 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS; cytoplasmic protein; hypothetical protein 1009280 4552211 MUL_0962 Mycobacterium ulcerans Agy99 hypothetical protein YP_905055.1 1009053 D 362242 CDS YP_905056.1 118616724 4552213 1010063..1011928 1 NC_008611.1 secreted protein; PPE family protein 1011928 4552213 MUL_0964 Mycobacterium ulcerans Agy99 PPE family protein YP_905056.1 1010063 D 362242 CDS YP_905057.1 118616725 4552214 1012406..1015081 1 NC_008611.1 secreted protein; PPE family protein 1015081 4552214 MUL_0965 Mycobacterium ulcerans Agy99 PPE family protein YP_905057.1 1012406 D 362242 CDS YP_905058.1 118616726 4552215 complement(1015138..1016472) 1 NC_008611.1 cytoplasmic protein; required for the transposition of the insertion element IS2606.; transposase for IS2606 1016472 4552215 MUL_0966 Mycobacterium ulcerans Agy99 transposase for IS2606 YP_905058.1 1015138 R 362242 CDS YP_905059.1 118616727 4552216 complement(1016724..1018367) 1 NC_008611.1 secreted protein; PE family protein 1018367 4552216 MUL_0967 Mycobacterium ulcerans Agy99 PE family protein YP_905059.1 1016724 R 362242 CDS YP_905060.1 118616728 4552219 1022048..1023196 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS. Also detected in the membrane fraction by proteomics (2D-LC-MS/MS); cytoplasmic protein; function unknown, but involved in lipid degradation [catalytic activity: 2 acetyl-CoA = CoA + acetoacetyl- CoA]; acetyl-CoA acetyltransferase FadA6_3 1023196 fadA6_3 4552219 fadA6_3 Mycobacterium ulcerans Agy99 acetyl-CoA acetyltransferase FadA6_3 YP_905060.1 1022048 D 362242 CDS YP_905061.1 118616729 4552794 1023193..1023996 1 NC_008611.1 cytoplasmic protein; oxidize fatty acids using specific components [catalytic activity: (3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H(2)O]; enoyl-CoA hydratase, EchA1_1 1023996 echA1_1 4552794 echA1_1 Mycobacterium ulcerans Agy99 enoyl-CoA hydratase, EchA1_1 YP_905061.1 1023193 D 362242 CDS YP_905062.1 118616730 4552796 complement(1026444..1027778) 1 NC_008611.1 cytoplasmic protein; required for the transposition of the insertion element IS2606.; transposase for IS2606 1027778 4552796 MUL_0974 Mycobacterium ulcerans Agy99 transposase for IS2606 YP_905062.1 1026444 R 362242 CDS YP_905063.1 118616731 4552798 complement(1028294..1029340) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 1029340 4552798 MUL_0976 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_905063.1 1028294 R 362242 CDS YP_905064.1 118616732 4552799 1029718..1031052 1 NC_008611.1 cytoplasmic protein; required for the transposition of the insertion element IS2606.; transposase for IS2606 1031052 4552799 MUL_0977 Mycobacterium ulcerans Agy99 transposase for IS2606 YP_905064.1 1029718 D 362242 CDS YP_905065.1 118616733 4552801 complement(1032499..1033767) 1 NC_008611.1 cytoplasmic protein; function unknown, probably involved in cellular metabolism.; oxidoreductase 1033767 4552801 MUL_0979 Mycobacterium ulcerans Agy99 oxidoreductase YP_905065.1 1032499 R 362242 CDS YP_905066.1 118616734 4552802 complement(1033764..1034273) 1 NC_008611.1 membrane protein; hypothetical protein 1034273 4552802 MUL_0980 Mycobacterium ulcerans Agy99 hypothetical protein YP_905066.1 1033764 R 362242 CDS YP_905067.1 118616735 4552804 1035419..1036522 1 NC_008611.1 cytoplasmic protein; hypothetical protein 1036522 4552804 MUL_0982 Mycobacterium ulcerans Agy99 hypothetical protein YP_905067.1 1035419 D 362242 CDS YP_905068.1 118616736 4552805 1036586..1037395 1 NC_008611.1 membrane protein; integral membrane protein 1037395 4552805 MUL_0983 Mycobacterium ulcerans Agy99 integral membrane protein YP_905068.1 1036586 D 362242 CDS YP_905069.1 118616737 4552807 complement(1038864..1039667) 1 NC_008611.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 1039667 echA10 4552807 echA10 Mycobacterium ulcerans Agy99 enoyl-CoA hydratase YP_905069.1 1038864 R 362242 CDS YP_905070.1 118616738 4552808 1039821..1040918 1 NC_008611.1 cytoplasmic protein; required for bile acid synthesis and for catabolism of branched-chain fatty acids; alpha-methylacyl-CoA racemase Mcr 1040918 mcr 4552808 mcr Mycobacterium ulcerans Agy99 alpha-methylacyl-CoA racemase Mcr YP_905070.1 1039821 D 362242 CDS YP_905071.1 118616739 4552809 1040976..1041737 1 NC_008611.1 Detected in the cytoplasmic and membrane fraction by LC-MS/MS. Also detected in the extracellular matrix by proteomics.; cytoplasmic protein; function unknown, supposed involved in cellular metabolism.; short-chain type dehydrogenase/reductase 1041737 4552809 MUL_0987 Mycobacterium ulcerans Agy99 short-chain type dehydrogenase/reductase YP_905071.1 1040976 D 362242 CDS YP_905072.1 118616740 4552810 complement(1041874..1042029) 1 NC_008611.1 hypothetical protein 1042029 4552810 MUL_0988 Mycobacterium ulcerans Agy99 hypothetical protein YP_905072.1 1041874 R 362242 CDS YP_905073.1 118616741 4552811 1042387..1044729 1 NC_008611.1 membrane protein; thought to be involved in fatty acid transport.; transmembrane transport protein MmpL13 1044729 mmpL13 4552811 mmpL13 Mycobacterium ulcerans Agy99 transmembrane transport protein MmpL13 YP_905073.1 1042387 D 362242 CDS YP_905074.1 118616742 4552812 1044746..1045429 1 NC_008611.1 cytoplasmic protein; involved in transcriptional mechanism.; TetR family transcriptional regulator 1045429 4552812 MUL_0990 Mycobacterium ulcerans Agy99 TetR family transcriptional regulator YP_905074.1 1044746 D 362242 CDS YP_905075.1 118616743 4552813 1045426..1046064 1 NC_008611.1 cytoplasmic protein; hypothetical protein 1046064 4552813 MUL_0991 Mycobacterium ulcerans Agy99 hypothetical protein YP_905075.1 1045426 D 362242 CDS YP_905076.1 118616744 4552814 complement(1046172..1046888) 1 NC_008611.1 Modulates the activities of several enzymes which are inactive in their acetylated form; NAD-dependent deacetylase 1046888 4552814 MUL_0992 Mycobacterium ulcerans Agy99 NAD-dependent deacetylase YP_905076.1 1046172 R 362242 CDS YP_905077.1 118616745 4552815 1046947..1047312 1 NC_008611.1 cytoplasmic protein; involved in transcriptional mechanism; transcriptional regulatory protein 1047312 4552815 MUL_0993 Mycobacterium ulcerans Agy99 transcriptional regulatory protein YP_905077.1 1046947 D 362242 CDS YP_905078.1 118616746 4552817 complement(1048174..1048725) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 1048725 4552817 MUL_0995 Mycobacterium ulcerans Agy99 hypothetical protein YP_905078.1 1048174 R 362242 CDS YP_905079.1 118616747 4552818 1048746..1049189 1 NC_008611.1 Also detected in the membrane fraction by proteomics (2D-LC-MS/MS); cytoplasmic protein; hypothetical protein 1049189 4552818 MUL_0996 Mycobacterium ulcerans Agy99 hypothetical protein YP_905079.1 1048746 D 362242 CDS YP_905080.1 118616748 4552819 1049212..1049400 1 NC_008611.1 cytoplasmic protein; hypothetical protein 1049400 4552819 MUL_0997 Mycobacterium ulcerans Agy99 hypothetical protein YP_905080.1 1049212 D 362242 CDS YP_905081.1 118616749 4552820 1050322..1050519 1 NC_008611.1 cytoplasmic protein; hypothetical protein 1050519 4552820 MUL_0998 Mycobacterium ulcerans Agy99 hypothetical protein YP_905081.1 1050322 D 362242 CDS YP_905082.1 118616750 4552821 complement(1050554..1050958) 1 NC_008611.1 membrane protein; hypothetical protein 1050958 4552821 MUL_0999 Mycobacterium ulcerans Agy99 hypothetical protein YP_905082.1 1050554 R 362242 CDS YP_905083.1 118616751 4552822 complement(1051011..1052057) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 1052057 4552822 MUL_1000 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_905083.1 1051011 R 362242 CDS YP_905084.1 118616752 4552823 complement(1052616..1053740) 1 NC_008611.1 membrane protein; hypothetical protein 1053740 4552823 MUL_1001 Mycobacterium ulcerans Agy99 hypothetical protein YP_905084.1 1052616 R 362242 CDS YP_905085.1 118616753 4552824 1053998..1054573 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; hypothetical protein 1054573 4552824 MUL_1002 Mycobacterium ulcerans Agy99 hypothetical protein YP_905085.1 1053998 D 362242 CDS YP_905086.1 118616754 4552825 1054598..1054744 1 NC_008611.1 cytoplasmic protein; hypothetical protein 1054744 4552825 MUL_1003 Mycobacterium ulcerans Agy99 hypothetical protein YP_905086.1 1054598 D 362242 CDS YP_905087.1 118616755 4552826 complement(1054776..1055987) 1 NC_008611.1 secreted protein; hypothetical protein 1055987 4552826 MUL_1004 Mycobacterium ulcerans Agy99 hypothetical protein YP_905087.1 1054776 R 362242 CDS YP_905088.1 118616756 4552827 complement(1056037..1056663) 1 NC_008611.1 secreted protein; hypothetical protein 1056663 4552827 MUL_1005 Mycobacterium ulcerans Agy99 hypothetical protein YP_905088.1 1056037 R 362242 CDS YP_905089.1 118616757 4552828 1056805..1058073 1 NC_008611.1 involved in the fifth mannose transfer of phosphatidylinositol mannoside synthesis; mannosyltransferase 1058073 pimE 4552828 pimE Mycobacterium ulcerans Agy99 mannosyltransferase YP_905089.1 1056805 D 362242 CDS YP_905090.1 118616758 4552829 complement(1058099..1058377) 1 NC_008611.1 4-alpha-hydroxytetrahydrobiopterin dehydratase activity; catalyzes the formation of (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7, 8-dihydro-6H-pterin from (6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7, 8-tetrahydro-4a-hydroxypterin; functions in recycling tetrahydrobiopterin (BH4) in phenylalanine hydroxylase reaction; pterin-4-alpha-carbinolamine dehydratase 1058377 phhB 4552829 phhB Mycobacterium ulcerans Agy99 pterin-4-alpha-carbinolamine dehydratase YP_905090.1 1058099 R 362242 CDS YP_905091.1 118616759 4552830 1058637..1059059 1 NC_008611.1 cytoplasmic protein; involved in the go system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8- oxoguanine) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite da and dc residues of template DNA with almost equal efficiency thus leading to AT to GC transversions. MutT specifically degrades 8-oxo-dGTP to the monophosphate.; mutator protein MutT2 1059059 mutT2 4552830 mutT2 Mycobacterium ulcerans Agy99 mutator protein MutT2 YP_905091.1 1058637 D 362242 CDS YP_905092.1 118616760 4552831 1059311..1061197 1 NC_008611.1 cytoplasmic protein; function unknown, probably interacts with the ribosomes in a GTP dependent manner; GTP-binding translation elongation factor TypA 1061197 typA 4552831 typA Mycobacterium ulcerans Agy99 GTP-binding translation elongation factor TypA YP_905092.1 1059311 D 362242 CDS YP_905093.1 118616761 4552832 1061301..1063199 1 NC_008611.1 membrane protein; lipoprotein LpqW 1063199 lpqW 4552832 lpqW Mycobacterium ulcerans Agy99 lipoprotein LpqW YP_905093.1 1061301 D 362242 CDS YP_905094.1 118616762 4552833 1063504..1064550 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 1064550 4552833 MUL_1011 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_905094.1 1063504 D 362242 CDS YP_905095.1 118616763 4552834 1064784..1066115 1 NC_008611.1 cytoplasmic protein; required for the transposition of the insertion element IS2606.; transposase for IS2606 1066115 4552834 MUL_1012 Mycobacterium ulcerans Agy99 transposase for IS2606 YP_905095.1 1064784 D 362242 CDS YP_905096.1 118616764 4552838 1070568..1071473 1 NC_008611.1 cytoplasmic protein; involved in mycothiol biosynthesis. 1-D-myo- inosityl-2-acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins)is converted to 1-D-myo-inosityl-2-amino-2- deoxy-alpha-D-glucopyranoside (GlcN-Ins) by this enzyme. seems to possesse weak mycothiol conjugate ami; N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha- D-glucopyranoside deacetylase MshB 1071473 mshB 4552838 mshB Mycobacterium ulcerans Agy99 N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha- D-glucopyranoside deacetylase MshB YP_905096.1 1070568 D 362242 CDS YP_905097.1 118616765 4552839 1071684..1072043 1 NC_008611.1 membrane protein; function unknown -possibly a transmembrane protein; hypothetical protein 1072043 4552839 MUL_1018 Mycobacterium ulcerans Agy99 hypothetical protein YP_905097.1 1071684 D 362242 CDS YP_905098.1 118616766 4552840 complement(1072073..1072960) 1 NC_008611.1 secreted protein; PE family protein 1072960 4552840 MUL_1019 Mycobacterium ulcerans Agy99 PE family protein YP_905098.1 1072073 R 362242 CDS YP_905099.1 118616767 4552841 1073165..1075735 1 NC_008611.1 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase; catalyzes radical-mediated transfer of hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO); functions in F420 biosynthesis; FO synthase 1075735 fbiC 4552841 fbiC Mycobacterium ulcerans Agy99 FO synthase YP_905099.1 1073165 D 362242 CDS YP_905100.1 118616768 4552842 1076307..1078850 1 NC_008611.1 membrane protein; PE-PGRS family protein 1078850 4552842 MUL_1021 Mycobacterium ulcerans Agy99 PE-PGRS family protein YP_905100.1 1076307 D 362242 CDS YP_905101.1 118616769 4552692 complement(1079060..1079395) 1 NC_008611.1 secreted protein; function unknown function (secreted protein); putative antigen 1079395 4552692 MUL_1022 Mycobacterium ulcerans Agy99 putative antigen YP_905101.1 1079060 R 362242 CDS YP_905102.1 118616770 4552693 complement(1079607..1081631) 1 NC_008611.1 cytoplasmic protein; catalyzes the NADP-dependent reduction of 2,4- dienoyl-CoA to yield trans-2- enoyl-CoA [catalytic activity: trans-2,3-didehydroacyl-CoA + NADP(+) = trans, trans-2,3,4,5-tetradehydroacyl-CoA + NADPH]; NADPH dependent 2,4-dienoyl-CoA reductase FadH 1081631 fadH 4552693 fadH Mycobacterium ulcerans Agy99 NADPH dependent 2,4-dienoyl-CoA reductase FadH YP_905102.1 1079607 R 362242 CDS YP_905103.1 118616771 4552694 complement(1081631..1082374) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 1082374 4552694 MUL_1024 Mycobacterium ulcerans Agy99 hypothetical protein YP_905103.1 1081631 R 362242 CDS YP_905104.1 118616772 4552695 1082411..1082737 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.; ferredoxin FdxC 1082737 fdxC 4552695 fdxC Mycobacterium ulcerans Agy99 ferredoxin FdxC YP_905104.1 1082411 D 362242 CDS YP_905105.1 118616773 4552696 1082767..1083864 1 NC_008611.1 catalyzes the formation of N-succinyl-LL-2,6-diaminopimelate from N-succinyl-L-2-amino-6-oxopimelate in lysine biosynthesis; N-succinyldiaminopimelate aminotransferase 1083864 4552696 MUL_1026 Mycobacterium ulcerans Agy99 N-succinyldiaminopimelate aminotransferase YP_905105.1 1082767 D 362242 CDS YP_905106.1 118616774 4552699 1089450..1090784 1 NC_008611.1 cytoplasmic protein; required for the transposition of the insertion element IS2606.; transposase for IS2606 1090784 4552699 MUL_1030 Mycobacterium ulcerans Agy99 transposase for IS2606 YP_905106.1 1089450 D 362242 CDS YP_905107.1 118616775 4552703 complement(1093210..1094727) 1 NC_008611.1 PE4; membrane protein; PE family protein 1094727 4552703 MUL_1034 Mycobacterium ulcerans Agy99 PE family protein YP_905107.1 1093210 R 362242 CDS YP_905108.1 118616776 4552704 complement(1094855..1095775) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 1095775 4552704 MUL_1035 Mycobacterium ulcerans Agy99 hypothetical protein YP_905108.1 1094855 R 362242 CDS YP_905109.1 118616777 4552706 1096982..1097722 1 NC_008611.1 cytoplasmic protein; not really known; thought to be involved in lipid biosynthesis [catalytic activity: androstan-3-alpha,17- beta-diol + NAD+ = 17-beta-hydroxyandrostan-3-one + NADH]; 20-beta-hydroxysteroid dehydrogenase FabG3 1097722 fabG3 4552706 fabG3 Mycobacterium ulcerans Agy99 20-beta-hydroxysteroid dehydrogenase FabG3 YP_905109.1 1096982 D 362242 CDS YP_905110.1 118616778 4552707 1097743..1099083 1 NC_008611.1 membrane protein; function unknown, probably involved in cellular metabolism.; oxidoreductase 1099083 4552707 MUL_1038 Mycobacterium ulcerans Agy99 oxidoreductase YP_905110.1 1097743 D 362242 CDS YP_905111.1 118616779 4552708 complement(1099090..1099635) 1 NC_008611.1 cytoplasmic protein; function unknown. contains TetR_N, bacterial regulatory proteins, TetR family domain. possibly involved in transcriptional mechanism.; putative regulatory protein 1099635 4552708 MUL_1039 Mycobacterium ulcerans Agy99 putative regulatory protein YP_905111.1 1099090 R 362242 CDS YP_905112.1 118616780 4553194 1102416..1103312 1 NC_008611.1 cytoplasmic protein; hypothetical protein 1103312 4553194 MUL_1043 Mycobacterium ulcerans Agy99 hypothetical protein YP_905112.1 1102416 D 362242 CDS YP_905113.1 118616781 4553195 complement(1103335..1104012) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 1104012 4553195 MUL_1044 Mycobacterium ulcerans Agy99 hypothetical protein YP_905113.1 1103335 R 362242 CDS YP_905114.1 118616782 4553196 complement(1103877..1105163) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 1105163 4553196 MUL_1045 Mycobacterium ulcerans Agy99 hypothetical protein YP_905114.1 1103877 R 362242 CDS YP_905115.1 118616783 4553197 1105280..1106449 1 NC_008611.1 cytoplasmic protein; acyl-CoA transferase 1106449 4553197 MUL_1046 Mycobacterium ulcerans Agy99 acyl-CoA transferase YP_905115.1 1105280 D 362242 CDS YP_905116.1 118616784 4553198 1106691..1107059 1 NC_008611.1 cytoplasmic protein; hypothetical protein 1107059 4553198 MUL_1047 Mycobacterium ulcerans Agy99 hypothetical protein YP_905116.1 1106691 D 362242 CDS YP_905117.1 118616785 4553200 1107880..1109088 1 NC_008611.1 cytoplasmic protein; cytochromes P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.; cytochrome P450 191A3 Cyp191A3 1109088 cyp191A3 4553200 cyp191A3 Mycobacterium ulcerans Agy99 cytochrome P450 191A3 Cyp191A3 YP_905117.1 1107880 D 362242 CDS YP_905118.1 118616786 4553202 1110055..1110816 1 NC_008611.1 cytoplasmic protein; hypothetical protein 1110816 4553202 MUL_1051 Mycobacterium ulcerans Agy99 hypothetical protein YP_905118.1 1110055 D 362242 CDS YP_905119.1 118616787 4553203 1110813..1111547 1 NC_008611.1 cytoplasmic protein; short chain dehydrogenase 1111547 4553203 MUL_1052 Mycobacterium ulcerans Agy99 short chain dehydrogenase YP_905119.1 1110813 D 362242 CDS YP_905120.1 118616788 4553204 1111544..1113136 1 NC_008611.1 membrane protein; function unknown, probably involved in cellular metabolism.; monooxygenase 1113136 4553204 MUL_1053 Mycobacterium ulcerans Agy99 monooxygenase YP_905120.1 1111544 D 362242 CDS YP_905121.1 118616789 4553205 1113151..1113987 1 NC_008611.1 cytoplasmic protein; function unknown, lipolytic enzyme probably involved in cellular metabolism.; esterase LipW 1113987 lipW 4553205 lipW Mycobacterium ulcerans Agy99 esterase LipW YP_905121.1 1113151 D 362242 CDS YP_905122.1 118616790 4553207 1115138..1115611 1 NC_008611.1 hypothetical protein 1115611 4553207 MUL_1056 Mycobacterium ulcerans Agy99 hypothetical protein YP_905122.1 1115138 D 362242 CDS YP_905123.1 118616791 4553208 1115663..1116124 1 NC_008611.1 Also detected in the membrane fraction by proteomics (LC-MS/MS); cytoplasmic protein; hypothetical protein 1116124 4553208 MUL_1057 Mycobacterium ulcerans Agy99 hypothetical protein YP_905123.1 1115663 D 362242 CDS YP_905124.1 118616792 4553209 complement(1116149..1116841) 1 NC_008611.1 cytoplasmic protein; possibly involved in transcriptional mechanism.; GntR family transcriptional regulator 1116841 4553209 MUL_1058 Mycobacterium ulcerans Agy99 GntR family transcriptional regulator YP_905124.1 1116149 R 362242 CDS YP_905125.1 118616793 4553211 1118876..1119679 1 NC_008611.1 membrane protein; integral membrane protein YrbE1A 1119679 yrbE1A 4553211 yrbE1A Mycobacterium ulcerans Agy99 integral membrane protein YrbE1A YP_905125.1 1118876 D 362242 CDS YP_905126.1 118616794 4553212 1119681..1120550 1 NC_008611.1 membrane protein; integral membrane protein YrbE1B 1120550 yrbE1B 4553212 yrbE1B Mycobacterium ulcerans Agy99 integral membrane protein YrbE1B YP_905126.1 1119681 D 362242 CDS YP_905127.1 118616795 4553213 1120555..1121859 1 NC_008611.1 membrane protein; function unknown, but thought to be involved in host cell invasion (entry and survival inside macrophages); MCE-family protein Mce1A 1121859 mce1A 4553213 mce1A Mycobacterium ulcerans Agy99 MCE-family protein Mce1A YP_905127.1 1120555 D 362242 CDS YP_905128.1 118616796 4553214 1121856..1122896 1 NC_008611.1 Detected in the membrane fraction by proteomics (2D- LC-MS/MS); membrane protein; function unknown, but thought to be involved in host cell invasion.; MCE-family protein Mce1B 1122896 mce1B 4553214 mce1B Mycobacterium ulcerans Agy99 MCE-family protein Mce1B YP_905128.1 1121856 D 362242 CDS YP_905129.1 118616797 4553215 1122893..1124458 1 NC_008611.1 membrane protein; function unknown, but thought to be involved in host cell invasion.; MCE-family protein Mce1C 1124458 mce1C 4553215 mce1C Mycobacterium ulcerans Agy99 MCE-family protein Mce1C YP_905129.1 1122893 D 362242 CDS YP_905130.1 118616798 4553216 1124455..1126062 1 NC_008611.1 membrane protein; function unknown, but thought to be involved in host cell invasion.; MCE-family protein Mce1D 1126062 mce1D 4553216 mce1D Mycobacterium ulcerans Agy99 MCE-family protein Mce1D YP_905130.1 1124455 D 362242 CDS YP_905131.1 118616799 4553217 1126080..1127285 1 NC_008611.1 Detected in the membrane fraction by proteomics (2D- LC-MS/MS); membrane protein; function unknown, but thought to be involved in host cell invasion.; MCE family lipoprotein LprK 1127285 lprK 4553217 lprK Mycobacterium ulcerans Agy99 MCE family lipoprotein LprK YP_905131.1 1126080 D 362242 CDS YP_905132.1 118616800 4553218 1127279..1128832 1 NC_008611.1 Also detected in the membrane fraction by proteomics.; membrane protein; function unknown, but thought involved in host cell invasion.; MCE-family protein Mce1F 1128832 mce1F 4553218 mce1F Mycobacterium ulcerans Agy99 MCE-family protein Mce1F YP_905132.1 1127279 D 362242 CDS YP_905133.1 118616801 4553219 1128856..1129530 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS) Also detected in the cytoplasmic fraction (2D- MALDI); membrane protein; Mce associated membrane protein 1129530 4553219 MUL_1068 Mycobacterium ulcerans Agy99 Mce associated membrane protein YP_905133.1 1128856 D 362242 CDS YP_905134.1 118616802 4553220 1129527..1130516 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; Mce associated transmembrane protein 1130516 4553220 MUL_1069 Mycobacterium ulcerans Agy99 Mce associated transmembrane protein YP_905134.1 1129527 D 362242 CDS YP_905135.1 118616803 4553221 1130513..1131070 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; Mce associated protein 1131070 4553221 MUL_1070 Mycobacterium ulcerans Agy99 Mce associated protein YP_905135.1 1130513 D 362242 CDS YP_905136.1 118616804 4553222 1131037..1131831 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; Mce associated membrane protein 1131831 4553222 MUL_1071 Mycobacterium ulcerans Agy99 Mce associated membrane protein YP_905136.1 1131037 D 362242 CDS YP_905137.1 118616805 4553224 complement(1133090..1134463) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; transmembrane protein 1134463 4553224 MUL_1073 Mycobacterium ulcerans Agy99 transmembrane protein YP_905137.1 1133090 R 362242 CDS YP_905138.1 118616806 4553226 complement(1135440..1136873) 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; hypothetical protein 1136873 4553226 MUL_1075 Mycobacterium ulcerans Agy99 hypothetical protein YP_905138.1 1135440 R 362242 CDS YP_905139.1 118616807 4553227 complement(1136870..1137931) 1 NC_008611.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; RNA polymerase factor sigma-70 1137931 sigG 4553227 sigG Mycobacterium ulcerans Agy99 RNA polymerase factor sigma-70 YP_905139.1 1136870 R 362242 CDS YP_905140.1 118616808 4553228 1137963..1138802 1 NC_008611.1 cytoplasmic protein; function unknown, probably involved in cellular metabolism.; lysophospholipase 1138802 4553228 MUL_1077 Mycobacterium ulcerans Agy99 lysophospholipase YP_905140.1 1137963 D 362242 CDS YP_905141.1 118616809 4553229 1138849..1139598 1 NC_008611.1 cytoplasmic protein; hypothetical protein 1139598 4553229 MUL_1078 Mycobacterium ulcerans Agy99 hypothetical protein YP_905141.1 1138849 D 362242 CDS YP_905142.1 118616810 4553230 1139595..1140119 1 NC_008611.1 cytoplasmic protein; function unknown, probably involved in a cellular metabolism.; hypothetical protein 1140119 4553230 MUL_1079 Mycobacterium ulcerans Agy99 hypothetical protein YP_905142.1 1139595 D 362242 CDS YP_905143.1 118616811 4553231 1140176..1142251 1 NC_008611.1 membrane protein; possibly involved in degradation [catalytic activity: hydrolysis of terminal, non-reducing beta-D- glucose residues with release of beta-D-glucose]; beta-glucosidase BglS 1142251 bglS 4553231 bglS Mycobacterium ulcerans Agy99 beta-glucosidase BglS YP_905143.1 1140176 D 362242 CDS YP_905144.1 118616812 4553233 complement(1145497..1147191) 1 NC_008611.1 catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; dihydroxy-acid dehydratase 1147191 ilvD 4553233 ilvD Mycobacterium ulcerans Agy99 dihydroxy-acid dehydratase YP_905144.1 1145497 R 362242 CDS YP_905145.1 118616813 4553234 1147331..1147621 1 NC_008611.1 cytoplasmic protein; hypothetical protein 1147621 4553234 MUL_1083 Mycobacterium ulcerans Agy99 hypothetical protein YP_905145.1 1147331 D 362242 CDS YP_905146.1 118616814 4553235 1147739..1148995 1 NC_008611.1 membrane protein; function unknown, possibly involved in transport of drug across the membrane.; integral membrane protein 1148995 4553235 MUL_1084 Mycobacterium ulcerans Agy99 integral membrane protein YP_905146.1 1147739 D 362242 CDS YP_905147.1 118616815 4553236 1149115..1150113 1 NC_008611.1 secreted protein; secretory protein 1150113 4553236 MUL_1085 Mycobacterium ulcerans Agy99 secretory protein YP_905147.1 1149115 D 362242 CDS YP_905148.1 118616816 4553237 1150332..1150907 1 NC_008611.1 cytoplasmic protein; possibly involved in transcriptional mechanism.; transcriptional regulatory protein 1150907 4553237 MUL_1086 Mycobacterium ulcerans Agy99 transcriptional regulatory protein YP_905148.1 1150332 D 362242 CDS YP_905149.1 118616817 4553239 complement(1153187..1155181) 1 NC_008611.1 cytoplasmic protein; function unknown, hydrolyzes peptides and/or proteins.; zinc metalloprotease 1155181 4553239 MUL_1088 Mycobacterium ulcerans Agy99 zinc metalloprotease YP_905149.1 1153187 R 362242 CDS YP_905150.1 118616818 4553240 1155224..1155871 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; hypothetical protein 1155871 4553240 MUL_1089 Mycobacterium ulcerans Agy99 hypothetical protein YP_905150.1 1155224 D 362242 CDS YP_905151.1 118616819 4553241 1155868..1156557 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; transmembrane protein 1156557 4553241 MUL_1090 Mycobacterium ulcerans Agy99 transmembrane protein YP_905151.1 1155868 D 362242 CDS YP_905152.1 118616820 4553242 complement(1156544..1157083) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 1157083 4553242 MUL_1091 Mycobacterium ulcerans Agy99 hypothetical protein YP_905152.1 1156544 R 362242 CDS YP_905153.1 118616821 4553243 complement(1157080..1160097) 1 NC_008611.1 membrane protein; function unknown. thought to be involved in fatty acid transport.; transmembrane transport protein MmpL11 1160097 mmpL11 4553243 mmpL11 Mycobacterium ulcerans Agy99 transmembrane transport protein MmpL11 YP_905153.1 1157080 R 362242 CDS YP_905154.1 118616822 4553244 1160452..1160961 1 NC_008611.1 secreted protein; exported protein 1160961 4553244 MUL_1093 Mycobacterium ulcerans Agy99 exported protein YP_905154.1 1160452 D 362242 CDS YP_905155.1 118616823 4553514 complement(1160963..1162180) 1 NC_008611.1 membrane protein; transmembrane protein 1162180 4553514 MUL_1094 Mycobacterium ulcerans Agy99 transmembrane protein YP_905155.1 1160963 R 362242 CDS YP_905156.1 118616824 4553516 complement(1163592..1166474) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS) Also detected in the cytoplasmic fraction by 2D-LC- MS/MS.; membrane protein; function unknown. thought to be involved in fatty acid transport.; transmembrane transport protein MmpL3 1166474 mmpL3 4553516 mmpL3 Mycobacterium ulcerans Agy99 transmembrane transport protein MmpL3 YP_905156.1 1163592 R 362242 CDS YP_905157.1 118616825 4553517 complement(1166580..1167317) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 1167317 4553517 MUL_1097 Mycobacterium ulcerans Agy99 hypothetical protein YP_905157.1 1166580 R 362242 CDS YP_905158.1 118616826 4553518 complement(1167355..1168191) 1 NC_008611.1 tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine; tRNA (guanine-N(7)-)-methyltransferase 1168191 trmB 4553518 trmB Mycobacterium ulcerans Agy99 tRNA (guanine-N(7)-)-methyltransferase YP_905158.1 1167355 R 362242 CDS YP_905159.1 118616827 4553519 1168355..1169485 1 NC_008611.1 cytoplasmic protein; hypothetical protein 1169485 4553519 MUL_1099 Mycobacterium ulcerans Agy99 hypothetical protein YP_905159.1 1168355 D 362242 CDS YP_905160.1 118616828 4553520 1169383..1171035 1 NC_008611.1 Also detected in the cytoplasmic fraction by 2D-LC- MS/MS.; secreted protein; hypothetical protein 1171035 4553520 MUL_1100 Mycobacterium ulcerans Agy99 hypothetical protein YP_905160.1 1169383 D 362242 CDS YP_905161.1 118616829 4553521 1171238..1173067 1 NC_008611.1 catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using GTP; phosphoenolpyruvate carboxykinase 1173067 pckA 4553521 pckA Mycobacterium ulcerans Agy99 phosphoenolpyruvate carboxykinase YP_905161.1 1171238 D 362242 CDS YP_905162.1 118616830 4553523 1174603..1175571 1 NC_008611.1 cytoplasmic protein; oxidizes fatty acids using specific components (by similarity) [catalytic activity: (3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H(2)O]; enoyl-CoA hydratase, EchA8_4 1175571 echA8_4 4553523 echA8_4 Mycobacterium ulcerans Agy99 enoyl-CoA hydratase, EchA8_4 YP_905162.1 1174603 D 362242 CDS YP_905163.1 118616831 4553524 complement(1175568..1175825) 1 NC_008611.1 membrane protein; hypothetical protein 1175825 4553524 MUL_1104 Mycobacterium ulcerans Agy99 hypothetical protein YP_905163.1 1175568 R 362242 CDS YP_905164.1 118616832 4553526 1177424..1178470 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 1178470 4553526 MUL_1106 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_905164.1 1177424 D 362242 CDS YP_905165.1 118616833 4553527 1178681..1179688 1 NC_008611.1 Detected in the membrane fraction by proteomics (2D- LC-MS/MS); membrane protein; hypothetical protein 1179688 4553527 MUL_1107 Mycobacterium ulcerans Agy99 hypothetical protein YP_905165.1 1178681 D 362242 CDS YP_905166.1 118616834 4553529 1180974..1182245 1 NC_008611.1 cytoplasmic protein; hypothetical protein 1182245 4553529 MUL_1109 Mycobacterium ulcerans Agy99 hypothetical protein YP_905166.1 1180974 D 362242 CDS YP_905167.1 118616835 4553531 1183273..1184619 1 NC_008611.1 membrane protein; hypothetical protein 1184619 4553531 MUL_1110 Mycobacterium ulcerans Agy99 hypothetical protein YP_905167.1 1183273 D 362242 CDS YP_905168.1 118616836 4553532 1184621..1185139 1 NC_008611.1 membrane protein; hypothetical protein 1185139 4553532 MUL_1111 Mycobacterium ulcerans Agy99 hypothetical protein YP_905168.1 1184621 D 362242 CDS YP_905169.1 118616837 4553533 1185295..1186473 1 NC_008611.1 cytoplasmic protein; function unknown, lipolytic enzyme probably involved in cellular metabolism.; esterase LipC 1186473 lipC 4553533 lipC Mycobacterium ulcerans Agy99 esterase LipC YP_905169.1 1185295 D 362242 CDS YP_905170.1 118616838 4553535 1187955..1188737 1 NC_008611.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 1188737 echA1 4553535 echA1 Mycobacterium ulcerans Agy99 enoyl-CoA hydratase YP_905170.1 1187955 D 362242 CDS YP_905171.1 118616839 4553536 1188836..1190323 1 NC_008611.1 cytoplasmic protein; function unknown, but involved in lipid degradation.; long-chain-fatty-acid-CoA ligase 1190323 4553536 MUL_1115 Mycobacterium ulcerans Agy99 long-chain-fatty-acid-CoA ligase YP_905171.1 1188836 D 362242 CDS YP_905172.1 118616840 4553537 1190353..1190616 1 NC_008611.1 cytoplasmic protein; hypothetical protein 1190616 4553537 MUL_1116 Mycobacterium ulcerans Agy99 hypothetical protein YP_905172.1 1190353 D 362242 CDS YP_905173.1 118616841 4553538 1191193..1192920 1 NC_008611.1 membrane protein; function unknown, but involvement in lipid degradation.; fatty-acid-CoA ligase 1192920 4553538 MUL_1117 Mycobacterium ulcerans Agy99 fatty-acid-CoA ligase YP_905173.1 1191193 D 362242 CDS YP_905174.1 118616842 4553540 complement(1197774..1198394) 1 NC_008611.1 membrane protein; possibly involved in transcriptional mechanism.; transcriptional regulatory protein 1198394 4553540 MUL_1119 Mycobacterium ulcerans Agy99 transcriptional regulatory protein YP_905174.1 1197774 R 362242 CDS YP_905175.1 118616843 4553541 1198750..1199520 1 NC_008611.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 1199520 4553541 MUL_1121 Mycobacterium ulcerans Agy99 enoyl-CoA hydratase YP_905175.1 1198750 D 362242 CDS YP_905176.1 118616844 4553542 complement(1199585..1201051) 1 NC_008611.1 membrane protein; thought to oxidize a wide variety of aliphatic and aromatic aldehydes.; aldehyde dehydrogenase 1201051 4553542 MUL_1122 Mycobacterium ulcerans Agy99 aldehyde dehydrogenase YP_905176.1 1199585 R 362242 CDS YP_905177.1 118616845 4553543 complement(1201096..1201863) 1 NC_008611.1 membrane protein; causes methylation; methyltransferase 1201863 4553543 MUL_1123 Mycobacterium ulcerans Agy99 methyltransferase YP_905177.1 1201096 R 362242 CDS YP_905178.1 118616846 4553544 1201919..1203082 1 NC_008611.1 cytoplasmic protein; function unknown, contains a glycosyltransferase domain (cell envelope biogenesis, outer membrane); glycosyltransferase 1203082 4553544 MUL_1124 Mycobacterium ulcerans Agy99 glycosyltransferase YP_905178.1 1201919 D 362242 CDS YP_905179.1 118616847 4553545 complement(1203092..1204879) 1 NC_008611.1 membrane protein; transmembrane protein 1204879 4553545 MUL_1125 Mycobacterium ulcerans Agy99 transmembrane protein YP_905179.1 1203092 R 362242 CDS YP_905180.1 118616848 4553546 complement(1204902..1206167) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; hypothetical protein 1206167 4553546 MUL_1126 Mycobacterium ulcerans Agy99 hypothetical protein YP_905180.1 1204902 R 362242 CDS YP_905181.1 118616849 4553547 1206320..1207528 1 NC_008611.1 membrane protein; function unknown, probably involved in cellular metabolism.; integral membrane acyltransferase 1207528 4553547 MUL_1127 Mycobacterium ulcerans Agy99 integral membrane acyltransferase YP_905181.1 1206320 D 362242 CDS YP_905182.1 118616850 4553549 1208362..1209408 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 1209408 4553549 MUL_1129 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_905182.1 1208362 D 362242 CDS YP_905183.1 118616851 4553451 complement(1210925..1211221) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 1211221 4553451 MUL_1130 Mycobacterium ulcerans Agy99 hypothetical protein YP_905183.1 1210925 R 362242 CDS YP_905184.1 118616852 4553452 complement(1211160..1211516) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 1211516 4553452 MUL_1131 Mycobacterium ulcerans Agy99 hypothetical protein YP_905184.1 1211160 R 362242 CDS YP_905185.1 118616853 4553453 complement(1211867..1212136) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 1212136 4553453 MUL_1132 Mycobacterium ulcerans Agy99 hypothetical protein YP_905185.1 1211867 R 362242 CDS YP_905186.1 118616854 4553454 complement(1212121..1213065) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 1213065 4553454 MUL_1133 Mycobacterium ulcerans Agy99 hypothetical protein YP_905186.1 1212121 R 362242 CDS YP_905187.1 118616855 4553455 complement(1213239..1213526) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 1213526 4553455 MUL_1134 Mycobacterium ulcerans Agy99 hypothetical protein YP_905187.1 1213239 R 362242 CDS YP_905188.1 118616856 4553456 1214094..1214321 1 NC_008611.1 cytoplasmic protein; hypothetical protein 1214321 4553456 MUL_1135 Mycobacterium ulcerans Agy99 hypothetical protein YP_905188.1 1214094 D 362242 CDS YP_905189.1 118616857 4553457 complement(1214390..1215136) 1 NC_008611.1 membrane protein; hypothetical protein 1215136 4553457 MUL_1136 Mycobacterium ulcerans Agy99 hypothetical protein YP_905189.1 1214390 R 362242 CDS YP_905190.1 118616858 4553459 complement(1215861..1216907) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 1216907 4553459 MUL_1138 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_905190.1 1215861 R 362242 CDS YP_905191.1 118616859 4553461 1218243..1218656 1 NC_008611.1 membrane protein; hypothetical protein 1218656 4553461 MUL_1140 Mycobacterium ulcerans Agy99 hypothetical protein YP_905191.1 1218243 D 362242 CDS YP_905192.1 118616860 4553462 1218666..1218959 1 NC_008611.1 membrane protein; hypothetical protein 1218959 4553462 MUL_1141 Mycobacterium ulcerans Agy99 hypothetical protein YP_905192.1 1218666 D 362242 CDS YP_905193.1 118616861 4553463 1219033..1219251 1 NC_008611.1 Detected in the cytoplasmic and secreted fractions by 2D-LC-MS/MS.; secreted protein; hypothetical protein 1219251 4553463 MUL_1142 Mycobacterium ulcerans Agy99 hypothetical protein YP_905193.1 1219033 D 362242 CDS YP_905194.1 118616862 4553464 complement(1219302..1220429) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 1220429 4553464 MUL_1143 Mycobacterium ulcerans Agy99 hypothetical protein YP_905194.1 1219302 R 362242 CDS YP_905195.1 118616863 4554016 complement(1220579..1221064) 1 NC_008611.1 membrane protein; hypothetical protein 1221064 4554016 MUL_1144 Mycobacterium ulcerans Agy99 hypothetical protein YP_905195.1 1220579 R 362242 CDS YP_905196.1 118616864 4554017 1221305..1223809 1 NC_008611.1 PE_PGRS30; secreted protein; PE-PGRS family protein 1223809 4554017 MUL_1145 Mycobacterium ulcerans Agy99 PE-PGRS family protein YP_905196.1 1221305 D 362242 CDS YP_905197.1 118616865 4554019 complement(1224435..1225769) 1 NC_008611.1 cytoplasmic protein; required for the transposition of the insertion element IS2606.; transposase for IS2606 1225769 4554019 MUL_1147 Mycobacterium ulcerans Agy99 transposase for IS2606 YP_905197.1 1224435 R 362242 CDS YP_905198.1 118616866 4554020 1226060..1227562 1 NC_008611.1 cytoplasmic protein; DNA polymerase 1227562 4554020 MUL_1148 Mycobacterium ulcerans Agy99 DNA polymerase YP_905198.1 1226060 D 362242 CDS YP_905199.1 118616867 4554021 complement(1227605..1228489) 1 NC_008611.1 secreted protein; PE-PGRS family protein 1228489 4554021 MUL_1149 Mycobacterium ulcerans Agy99 PE-PGRS family protein YP_905199.1 1227605 R 362242 CDS YP_905200.1 118616868 4554022 complement(1228670..1229650) 1 NC_008611.1 cytoplasmic protein; enzymatic activity is not yet known [catalytic activity: aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol]; phosphotriesterase PHP 1229650 php 4554022 php Mycobacterium ulcerans Agy99 phosphotriesterase PHP YP_905200.1 1228670 R 362242 CDS YP_905201.1 118616869 4554023 1229992..1231698 1 NC_008611.1 function unknown, but involved in lipid degradation.; acyl-CoA dehydrogenase FadE4 1231698 fadE4 4554023 fadE4 Mycobacterium ulcerans Agy99 acyl-CoA dehydrogenase FadE4 YP_905201.1 1229992 D 362242 CDS YP_905202.1 118616870 4554024 1231797..1232468 1 NC_008611.1 cytoplasmic protein; involved in transcriptional mechanism.; TetR family transcriptional regulator 1232468 4554024 MUL_1152 Mycobacterium ulcerans Agy99 TetR family transcriptional regulator YP_905202.1 1231797 D 362242 CDS YP_905203.1 118616871 4554025 complement(1232590..1233966) 1 NC_008611.1 NADP-dependent semialdehyde dehydrogenase; part of alternative pathway from alpha-ketoglutarate to succinate; succinic semialdehyde dehydrogenase 1233966 gabD1 4554025 gabD1 Mycobacterium ulcerans Agy99 succinic semialdehyde dehydrogenase YP_905203.1 1232590 R 362242 CDS YP_905204.1 118616872 4554026 1234414..1235598 1 NC_008611.1 membrane protein; PPE family protein 1235598 4554026 MUL_1154 Mycobacterium ulcerans Agy99 PPE family protein YP_905204.1 1234414 D 362242 CDS YP_905205.1 118616873 4554027 1235788..1238157 1 NC_008611.1 membrane protein; PE-PGRS family protein 1238157 4554027 MUL_1155 Mycobacterium ulcerans Agy99 PE-PGRS family protein YP_905205.1 1235788 D 362242 CDS YP_905206.1 118616874 4554028 complement(1238239..1239669) 1 NC_008611.1 membrane protein; hypothetical protein 1239669 4554028 MUL_1156 Mycobacterium ulcerans Agy99 hypothetical protein YP_905206.1 1238239 R 362242 CDS YP_905207.1 118616875 4554029 complement(1239794..1240555) 1 NC_008611.1 cytoplasmic protein; glycerophosphoryl diester phosphodiesterase hydrolyzes deacylated phospholipids to G3P and the corresponding alcohols [catalytic activity: a glycerophosphodiester + H(2)O = an alcohol + SN-glycerol 3- phosphate]; glycerophosphoryl diester phosphodiesterase GlpQ2 1240555 glpQ2 4554029 glpQ2 Mycobacterium ulcerans Agy99 glycerophosphoryl diester phosphodiesterase GlpQ2 YP_905207.1 1239794 R 362242 CDS YP_905208.1 118616876 4554030 1240719..1241279 1 NC_008611.1 secreted protein; hypothetical protein 1241279 4554030 MUL_1158 Mycobacterium ulcerans Agy99 hypothetical protein YP_905208.1 1240719 D 362242 CDS YP_905209.1 118616877 4554031 complement(1241283..1245461) 1 NC_008611.1 membrane protein; transmembrane protein 1245461 4554031 MUL_1159 Mycobacterium ulcerans Agy99 transmembrane protein YP_905209.1 1241283 R 362242 CDS YP_905210.1 118616878 4554032 complement(1245550..1245723) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); secreted protein; small secreted protein 1245723 4554032 MUL_1160 Mycobacterium ulcerans Agy99 small secreted protein YP_905210.1 1245550 R 362242 CDS YP_905211.1 118616879 4554033 complement(1245792..1246049) 1 NC_008611.1 secreted protein; putative small secreted protein 1246049 4554033 MUL_1161 Mycobacterium ulcerans Agy99 putative small secreted protein YP_905211.1 1245792 R 362242 CDS YP_905212.1 118616880 4554034 1246153..1247346 1 NC_008611.1 secreted protein; lipoprotein LpqI 1247346 lpqI 4554034 lpqI Mycobacterium ulcerans Agy99 lipoprotein LpqI YP_905212.1 1246153 D 362242 CDS YP_905213.1 118616881 4554035 1247433..1248059 1 NC_008611.1 cytoplasmic protein; possibly involved in transcriptional mechanism.; TetR family transcriptional regulator 1248059 4554035 MUL_1163 Mycobacterium ulcerans Agy99 TetR family transcriptional regulator YP_905213.1 1247433 D 362242 CDS YP_905214.1 118616882 4554036 1248078..1249373 1 NC_008611.1 membrane protein; function unknown, possibly ion channel involved in transport of chloride across the membrane.; transmembrane protein 1249373 4554036 MUL_1164 Mycobacterium ulcerans Agy99 transmembrane protein YP_905214.1 1248078 D 362242 CDS YP_905215.1 118616883 4554037 complement(1249385..1250236) 1 NC_008611.1 Detected in the membrane fraction by proteomics (2D- LC-MS/MS) Also detected in the cytoplasmic fraction.; membrane protein; hypothetical protein 1250236 4554037 MUL_1165 Mycobacterium ulcerans Agy99 hypothetical protein YP_905215.1 1249385 R 362242 CDS YP_905216.1 118616884 4554038 complement(1250255..1251619) 1 NC_008611.1 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-(acyl-carrier-protein) reductase 1251619 fabG 4554038 fabG Mycobacterium ulcerans Agy99 3-ketoacyl-(acyl-carrier-protein) reductase YP_905216.1 1250255 R 362242 CDS YP_905217.1 118616885 4554039 1251789..1253114 1 NC_008611.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; acetyl-CoA acetyltransferase 1253114 fadA2 4554039 fadA2 Mycobacterium ulcerans Agy99 acetyl-CoA acetyltransferase YP_905217.1 1251789 D 362242 CDS YP_905218.1 118616886 4554040 complement(1253399..1255264) 1 NC_008611.1 Detected in the cytoplasmic fraction by proteomics.; cytoplasmic protein; function unknown, but involved in lipid degradation.; acyl-CoA dehydrogenase FadE5 1255264 fadE5 4554040 fadE5 Mycobacterium ulcerans Agy99 acyl-CoA dehydrogenase FadE5 YP_905218.1 1253399 R 362242 CDS YP_905219.1 118616887 4554041 1255777..1256265 1 NC_008611.1 cytoplasmic protein; function unknown, probably involved in cellular metabolism.; oxidoreductase 1256265 4554041 MUL_1169 Mycobacterium ulcerans Agy99 oxidoreductase YP_905219.1 1255777 D 362242 CDS YP_905220.1 118616888 4554043 complement(1257341..1257499) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 1257499 4554043 MUL_5125 Mycobacterium ulcerans Agy99 hypothetical protein YP_905220.1 1257341 R 362242 CDS YP_905221.1 118616889 4554044 complement(1257547..1258293) 1 NC_008611.1 catalyzes the fumarate and succinate interconversion; fumarate reductase is used under anaerobic conditions with glucose or glycerol as carbon source; fumarate reductase iron-sulfur subunit 1258293 sdhB_1 4554044 sdhB_1 Mycobacterium ulcerans Agy99 fumarate reductase iron-sulfur subunit YP_905221.1 1257547 R 362242 CDS YP_905222.1 118616890 4554045 complement(1258293..1260221) 1 NC_008611.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; succinate dehydrogenase flavoprotein subunit 1260221 sdhA 4554045 sdhA Mycobacterium ulcerans Agy99 succinate dehydrogenase flavoprotein subunit YP_905222.1 1258293 R 362242 CDS YP_905223.1 118616891 4554046 complement(1260268..1261089) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; could be involved in interconversion of fumarate and succinate (aerobic respiration) this hydrophobic component may be required to anchor the catalytic components of the succinate dehydrogenase complex to the cytoplasmic membrane.; succinate dehydrogenase (membrane anchor subunit) 1261089 4554046 MUL_1173 Mycobacterium ulcerans Agy99 succinate dehydrogenase (membrane anchor subunit) YP_905223.1 1260268 R 362242 CDS YP_905224.1 118616892 4554048 1261636..1262340 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; N-term transposase for IS2404 1262340 4554048 MUL_1175 Mycobacterium ulcerans Agy99 N-term transposase for IS2404 YP_905224.1 1261636 D 362242 CDS YP_905225.1 118616893 4554049 1262365..1262682 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; C-term transposase for IS2404 1262682 4554049 MUL_1176 Mycobacterium ulcerans Agy99 C-term transposase for IS2404 YP_905225.1 1262365 D 362242 CDS YP_905226.1 118616894 4554050 1263037..1263726 1 NC_008611.1 cytoplasmic protein; PEP phosphonomutase 1263726 4554050 MUL_1177 Mycobacterium ulcerans Agy99 PEP phosphonomutase YP_905226.1 1263037 D 362242 CDS YP_905227.1 118616895 4554051 complement(1263801..1264259) 1 NC_008611.1 cytoplasmic protein; thought to be involved in the initiation step of translation at high temperature. bound to 30S ribosomal subunit. possibly a molecular chaperone. in M. tuberculosis H37Rv seems to be regulated positively by SigE and negatively by HspR.; heat shock protein Hsp 1264259 hsp 4554051 hsp Mycobacterium ulcerans Agy99 heat shock protein Hsp YP_905227.1 1263801 R 362242 CDS YP_905228.1 118616896 4554053 1267066..1267422 1 NC_008611.1 cytoplasmic protein; involved in nitrate assimilation (denitrification); required for activity of the reductase [catalytic activity: 3 NAD(P)H + nitrite = 3 NAD(P)+ + NH4OH + H2O]; nitrite reductase [NAD(P)H] small subunit NirD 1267422 nirD 4554053 nirD Mycobacterium ulcerans Agy99 nitrite reductase [NAD(P)H] small subunit NirD YP_905228.1 1267066 D 362242 CDS YP_905229.1 118616897 4554054 complement(1267559..1268014) 1 NC_008611.1 hypothetical protein 1268014 4554054 MUL_1181 Mycobacterium ulcerans Agy99 hypothetical protein YP_905229.1 1267559 R 362242 CDS YP_905230.1 118616898 4554055 complement(1268071..1268832) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 1268832 4554055 MUL_1182 Mycobacterium ulcerans Agy99 hypothetical protein YP_905230.1 1268071 R 362242 CDS YP_905231.1 118616899 4554056 complement(1268823..1269974) 1 NC_008611.1 catalyzes the formation of uroporphyrinogen-III from hydroxymethylbilane; bifunctional uroporphyrinogen-III synthetase/response regulator domain protein 1269974 4554056 MUL_1183 Mycobacterium ulcerans Agy99 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein YP_905231.1 1268823 R 362242 CDS YP_905232.1 118616900 4554058 complement(1271684..1272229) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; confers resistance to aminoglycosides (gentamicin, tobramycin, dibekacin, netilmicin, and 6'-N- ethylnetilmicin); aminoglycoside 2'-N-acetyltransferase Aac 1272229 aac 4554058 aac Mycobacterium ulcerans Agy99 aminoglycoside 2'-N-acetyltransferase Aac YP_905232.1 1271684 R 362242 CDS YP_905233.1 118616901 4554059 complement(1272256..1273125) 1 NC_008611.1 cytoplasmic protein; urea amidolyase-related protein 1273125 4554059 MUL_1186 Mycobacterium ulcerans Agy99 urea amidolyase-related protein YP_905233.1 1272256 R 362242 CDS YP_905234.1 118616902 4554060 complement(1273141..1273812) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 1273812 4554060 MUL_1187 Mycobacterium ulcerans Agy99 hypothetical protein YP_905234.1 1273141 R 362242 CDS YP_905235.1 118616903 4554061 complement(1273925..1274917) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; thought to be involved in iron transport across the membrane (import); periplasmic iron-transport lipoprotein 1274917 4554061 MUL_1188 Mycobacterium ulcerans Agy99 periplasmic iron-transport lipoprotein YP_905235.1 1273925 R 362242 CDS YP_905236.1 118616904 4554062 1275171..1276568 1 NC_008611.1 membrane protein; involved in excretion of nitrite produced by the dissimilatory reduction of nitrate. responsible for the translocation of the substrate across the membrane.; integral membrane nitrite extrusion protein NarU 1276568 narU 4554062 narU Mycobacterium ulcerans Agy99 integral membrane nitrite extrusion protein NarU YP_905236.1 1275171 D 362242 CDS YP_905237.1 118616905 4554063 complement(1276569..1277840) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 1277840 4554063 MUL_1190 Mycobacterium ulcerans Agy99 hypothetical protein YP_905237.1 1276569 R 362242 CDS YP_905238.1 118616906 4554064 1277899..1279572 1 NC_008611.1 activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 1279572 fadD2 4554064 fadD2 Mycobacterium ulcerans Agy99 acyl-CoA synthetase YP_905238.1 1277899 D 362242 CDS YP_905239.1 118616907 4554065 complement(1280018..1281370) 1 NC_008611.1 membrane protein; hypothetical protein 1281370 4554065 MUL_1193 Mycobacterium ulcerans Agy99 hypothetical protein YP_905239.1 1280018 R 362242 CDS YP_905240.1 118616908 4554066 complement(1281606..1283792) 1 NC_008611.1 cytoplasmic protein; function unknown, but involved in lipid degradation.; acyl-CoA dehydrogenase FadE6 1283792 fadE6 4554066 fadE6 Mycobacterium ulcerans Agy99 acyl-CoA dehydrogenase FadE6 YP_905240.1 1281606 R 362242 CDS YP_905241.1 118616909 4554067 complement(1283849..1284811) 1 NC_008611.1 cytoplasmic protein; involved at the first committed step in the 'phosphorylated' pathway of L-serine biosynthesis [catalytic activity: 3-phosphoglycerate + NAD(+) = 3- phosphohydroxypyruvate + NADH]; D-3-phosphoglycerate dehydrogenase SerA3 1284811 serA3 4554067 serA3 Mycobacterium ulcerans Agy99 D-3-phosphoglycerate dehydrogenase SerA3 YP_905241.1 1283849 R 362242 CDS YP_905242.1 118616910 4554068 complement(1284808..1285941) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; hypothetical protein 1285941 4554068 MUL_1196 Mycobacterium ulcerans Agy99 hypothetical protein YP_905242.1 1284808 R 362242 CDS YP_905243.1 118616911 4554069 complement(1285943..1286551) 1 NC_008611.1 cytoplasmic protein; could be involved in transcriptional mechanism.; transcriptional regulatory protein 1286551 4554069 MUL_1197 Mycobacterium ulcerans Agy99 transcriptional regulatory protein YP_905243.1 1285943 R 362242 CDS YP_905244.1 118616912 4554070 1286642..1287223 1 NC_008611.1 Detected in the membrane fraction by proteomics (2D- LC-MS/MS); cytoplasmic protein; hypothetical protein 1287223 4554070 MUL_1198 Mycobacterium ulcerans Agy99 hypothetical protein YP_905244.1 1286642 D 362242 CDS YP_905245.1 118616913 4554071 1287230..1287778 1 NC_008611.1 membrane protein; hypothetical protein 1287778 4554071 MUL_1199 Mycobacterium ulcerans Agy99 hypothetical protein YP_905245.1 1287230 D 362242 CDS YP_905246.1 118616914 4554407 complement(1287732..1288388) 1 NC_008611.1 cytoplasmic protein; could be involved in transcriptional mechanism.; TetR family transcriptional regulator 1288388 4554407 MUL_1200 Mycobacterium ulcerans Agy99 TetR family transcriptional regulator YP_905246.1 1287732 R 362242 CDS YP_905247.1 118616915 4554408 1288513..1289415 1 NC_008611.1 hypothetical protein 1289415 4554408 MUL_1201 Mycobacterium ulcerans Agy99 hypothetical protein YP_905247.1 1288513 D 362242 CDS YP_905248.1 118616916 4554409 1289688..1291244 1 NC_008611.1 PPE3; secreted protein; PPE family protein 1291244 4554409 MUL_1202 Mycobacterium ulcerans Agy99 PPE family protein YP_905248.1 1289688 D 362242 CDS YP_905249.1 118616917 4554411 1292296..1292520 1 NC_008611.1 cytoplasmic protein; hypothetical protein 1292520 4554411 MUL_5109 Mycobacterium ulcerans Agy99 hypothetical protein YP_905249.1 1292296 D 362242 CDS YP_905250.1 118616918 4554412 1292627..1294489 1 NC_008611.1 Detected in the cytoplasmic and the membrane fraction by 2D-LC-MS/MS.; cytoplasmic protein; hypothetical protein 1294489 4554412 MUL_1204 Mycobacterium ulcerans Agy99 hypothetical protein YP_905250.1 1292627 D 362242 CDS YP_905251.1 118616919 4554413 1294486..1296087 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; hypothetical protein 1296087 4554413 MUL_1205 Mycobacterium ulcerans Agy99 hypothetical protein YP_905251.1 1294486 D 362242 CDS YP_905252.1 118616920 4554414 1296084..1300085 1 NC_008611.1 membrane protein; hypothetical protein 1300085 4554414 MUL_1206 Mycobacterium ulcerans Agy99 hypothetical protein YP_905252.1 1296084 D 362242 CDS YP_905253.1 118616921 4554415 1300110..1300418 1 NC_008611.1 PE5; Detected in the secreted fraction by proteomics.; secreted protein; PE family protein 1300418 4554415 MUL_1207 Mycobacterium ulcerans Agy99 PE family protein YP_905253.1 1300110 D 362242 CDS YP_905254.1 118616922 4554416 1300421..1301974 1 NC_008611.1 PPE4; membrane protein; PPE family protein 1301974 4554416 MUL_1208 Mycobacterium ulcerans Agy99 PPE family protein YP_905254.1 1300421 D 362242 CDS YP_905255.1 118616923 4554417 1302011..1302304 1 NC_008611.1 secreted protein; EsaT-6 like protein EsxG 1302304 esxG 4554417 esxG Mycobacterium ulcerans Agy99 EsaT-6 like protein EsxG YP_905255.1 1302011 D 362242 CDS YP_905256.1 118616924 4554418 1302333..1302623 1 NC_008611.1 membrane protein; EsaT-6 like protein EsxH 1302623 esxH 4554418 esxH Mycobacterium ulcerans Agy99 EsaT-6 like protein EsxH YP_905256.1 1302333 D 362242 CDS YP_905257.1 118616925 4554419 1302632..1303528 1 NC_008611.1 Detected in the membrane fraction by proteomics.; cytoplasmic protein; hypothetical protein 1303528 4554419 MUL_1211 Mycobacterium ulcerans Agy99 hypothetical protein YP_905257.1 1302632 D 362242 CDS YP_905258.1 118616926 4554420 1303600..1305018 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; transmembrane protein 1305018 4554420 MUL_1212 Mycobacterium ulcerans Agy99 transmembrane protein YP_905258.1 1303600 D 362242 CDS YP_905259.1 118616927 4554421 1305015..1306439 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS) Also detected in the cytoplasm by proteomics.; membrane protein; thought to have proteolytic activity.; membrane-anchored mycosin MycP3 1306439 mycP3 4554421 mycP3 Mycobacterium ulcerans Agy99 membrane-anchored mycosin MycP3 YP_905259.1 1305015 D 362242 CDS YP_905260.1 118616928 4554422 1306492..1307442 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; transmembrane protein 1307442 4554422 MUL_1214 Mycobacterium ulcerans Agy99 transmembrane protein YP_905260.1 1306492 D 362242 CDS YP_905261.1 118616929 4554423 complement(1307429..1308649) 1 NC_008611.1 membrane protein; hypothetical protein 1308649 4554423 MUL_1215 Mycobacterium ulcerans Agy99 hypothetical protein YP_905261.1 1307429 R 362242 CDS YP_905262.1 118616930 4554424 1308806..1309597 1 NC_008611.1 catalyzes the formation of (E)-3-(methoxycarbonyl)pent-2-enedioate and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and trans-aconitate; trans-aconitate 2-methyltransferase 1309597 tam 4554424 tam Mycobacterium ulcerans Agy99 trans-aconitate 2-methyltransferase YP_905262.1 1308806 D 362242 CDS YP_905263.1 118616931 4554425 complement(1309615..1310970) 1 NC_008611.1 cytoplasmic protein; function unknown, probably involved in cellular metabolism.; sulfatase 1310970 4554425 MUL_1217 Mycobacterium ulcerans Agy99 sulfatase YP_905263.1 1309615 R 362242 CDS YP_905264.1 118616932 4554426 complement(1311079..1311729) 1 NC_008611.1 cytoplasmic protein; function unknown, probably involved in cellular metabolism.; oxidoreductase 1311729 4554426 MUL_1218 Mycobacterium ulcerans Agy99 oxidoreductase YP_905264.1 1311079 R 362242 CDS YP_905265.1 118616933 4554427 complement(1311722..1311922) 1 NC_008611.1 Detected in the membrane fraction by proteomics; membrane protein; membrane protein 1311922 4554427 MUL_1219 Mycobacterium ulcerans Agy99 membrane protein YP_905265.1 1311722 R 362242 CDS YP_905266.1 118616934 4554428 1311915..1312172 1 NC_008611.1 membrane protein; hypothetical protein 1312172 4554428 MUL_1220 Mycobacterium ulcerans Agy99 hypothetical protein YP_905266.1 1311915 D 362242 CDS YP_905267.1 118616935 4554429 complement(1312156..1312638) 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; hypothetical protein 1312638 4554429 MUL_1221 Mycobacterium ulcerans Agy99 hypothetical protein YP_905267.1 1312156 R 362242 CDS YP_905268.1 118616936 4554430 1312695..1313363 1 NC_008611.1 membrane protein; integral membrane protein 1313363 4554430 MUL_1222 Mycobacterium ulcerans Agy99 integral membrane protein YP_905268.1 1312695 D 362242 CDS YP_905269.1 118616937 4554431 1313469..1314125 1 NC_008611.1 secreted protein; hypothetical protein 1314125 4554431 MUL_1223 Mycobacterium ulcerans Agy99 hypothetical protein YP_905269.1 1313469 D 362242 CDS YP_905270.1 118616938 4554432 complement(1314134..1314640) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 1314640 4554432 MUL_1224 Mycobacterium ulcerans Agy99 hypothetical protein YP_905270.1 1314134 R 362242 CDS YP_905271.1 118616939 4554433 1314700..1315929 1 NC_008611.1 cytoplasmic protein; hypothetical protein 1315929 4554433 MUL_1225 Mycobacterium ulcerans Agy99 hypothetical protein YP_905271.1 1314700 D 362242 CDS YP_905272.1 118616940 4554434 1316082..1317962 1 NC_008611.1 membrane protein; hypothetical protein 1317962 4554434 MUL_1226 Mycobacterium ulcerans Agy99 hypothetical protein YP_905272.1 1316082 D 362242 CDS YP_905273.1 118616941 4554435 1318184..1319542 1 NC_008611.1 membrane protein; hypothetical protein 1319542 4554435 MUL_1227 Mycobacterium ulcerans Agy99 hypothetical protein YP_905273.1 1318184 D 362242 CDS YP_905274.1 118616942 4554437 1329776..1330147 1 NC_008611.1 cytoplasmic protein; hypothetical protein 1330147 4554437 MUL_1231 Mycobacterium ulcerans Agy99 hypothetical protein YP_905274.1 1329776 D 362242 CDS YP_905275.1 118616943 4554439 complement(1331902..1333845) 1 NC_008611.1 cytoplasmic protein; function unknown, but seems involved in metabolism of small branched-chain fatty acids and macrolide antibiotic production. catalyses the alpha, beta- dehydrogenetion of acyl-CoA esters and transfer electrons to ETF, the electron transfer protein.; acyl-CoA dehydrogenase 1333845 4554439 MUL_1233 Mycobacterium ulcerans Agy99 acyl-CoA dehydrogenase YP_905275.1 1331902 R 362242 CDS YP_905276.1 118616944 4554440 1334046..1334705 1 NC_008611.1 membrane protein 1334705 4554440 MUL_1234 Mycobacterium ulcerans Agy99 membrane protein YP_905276.1 1334046 D 362242 CDS YP_905277.1 118616945 4554442 1335782..1336828 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 1336828 4554442 MUL_1236 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_905277.1 1335782 D 362242 CDS YP_905278.1 118616946 4554443 complement(1337211..1339733) 1 NC_008611.1 membrane protein; thought to be involved in active transport of undeterminated substrate (possibly lipooligosaccharide) across the membrane. responsible for energy coupling to the transport system and for the translocation of the substrate across the membrane.; transmembrane ATP-binding protein ABC transporter 1339733 4554443 MUL_1237 Mycobacterium ulcerans Agy99 transmembrane ATP-binding protein ABC transporter YP_905278.1 1337211 R 362242 CDS YP_905279.1 118616947 4554444 complement(1339885..1340361) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 1340361 4554444 MUL_1238 Mycobacterium ulcerans Agy99 hypothetical protein YP_905279.1 1339885 R 362242 CDS YP_905280.1 118616948 4554509 1340480..1342552 1 NC_008611.1 membrane protein; probably involved in active transport accross the membrane. thought to be responsible for energy coupling to the transport system and the translocation of the substrate across the membrane.; transmembrane ATP-binding protein ABC transorter 1342552 4554509 MUL_1239 Mycobacterium ulcerans Agy99 transmembrane ATP-binding protein ABC transorter YP_905280.1 1340480 D 362242 CDS YP_905281.1 118616949 4554510 1342549..1343409 1 NC_008611.1 membrane protein; hypothetical protein 1343409 4554510 MUL_1240 Mycobacterium ulcerans Agy99 hypothetical protein YP_905281.1 1342549 D 362242 CDS YP_905282.1 118616950 4554511 complement(1343406..1343858) 1 NC_008611.1 cytoplasmic protein; involved in transcriptional mechanism.; AsnC family transcriptional regulator 1343858 4554511 MUL_1241 Mycobacterium ulcerans Agy99 AsnC family transcriptional regulator YP_905282.1 1343406 R 362242 CDS YP_905283.1 118616951 4554512 1343982..1344857 1 NC_008611.1 cytoplasmic protein; hypothetical protein 1344857 4554512 MUL_1242 Mycobacterium ulcerans Agy99 hypothetical protein YP_905283.1 1343982 D 362242 CDS YP_905284.1 118616952 4554513 1344854..1346098 1 NC_008611.1 cytoplasmic protein; involved in arginine metabolism [catalytic activity: L-ornithine + a 2-OXO acid = L-glutamate 5- semialdehyde + an L-amino acid]; ornithine aminotransferase RocD1 and RocD2 1346098 rocD 4554513 rocD Mycobacterium ulcerans Agy99 ornithine aminotransferase RocD1 and RocD2 YP_905284.1 1344854 D 362242 CDS YP_905285.1 118616953 4554514 1346128..1347597 1 NC_008611.1 membrane protein; thought to be involved in transport of cationic amino acid (especially arginine and ornithine) across the membrane. responsible for the translocation of the substrate across the membrane.; cationic amino acid transport integral membrane protein RocE 1347597 rocE 4554514 rocE Mycobacterium ulcerans Agy99 cationic amino acid transport integral membrane protein RocE YP_905285.1 1346128 D 362242 CDS YP_905286.1 118616954 4554515 1347594..1348466 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); cytoplasmic protein; hypothetical protein 1348466 4554515 MUL_1245 Mycobacterium ulcerans Agy99 hypothetical protein YP_905286.1 1347594 D 362242 CDS YP_905287.1 118616955 4554516 complement(1348497..1349825) 1 NC_008611.1 membrane protein; thought to be involved in active transport of sugar across the membrane (import); periplasmic sugar-binding lipoprotein UspC 1349825 uspC 4554516 uspC Mycobacterium ulcerans Agy99 periplasmic sugar-binding lipoprotein UspC YP_905287.1 1348497 R 362242 CDS YP_905288.1 118616956 4554517 complement(1349822..1350628) 1 NC_008611.1 secreted protein; thought to be involved in active transport of sugar across the membrane (import) responsible for the translocation of the substrate across the membrane.; sugar-transport integral membrane protein ABC transporter UspB 1350628 uspB 4554517 uspB Mycobacterium ulcerans Agy99 sugar-transport integral membrane protein ABC transporter UspB YP_905288.1 1349822 R 362242 CDS YP_905289.1 118616957 4554518 complement(1350648..1351520) 1 NC_008611.1 Also detected in the cytoplasm by proteomics.; membrane protein; thought to be involved in active transport of sugar across the membrane (import) responsible for the translocation of the substrate across the membrane.; sugar-transport integral membrane protein ABC transporter UspA 1351520 uspA 4554518 uspA Mycobacterium ulcerans Agy99 sugar-transport integral membrane protein ABC transporter UspA YP_905289.1 1350648 R 362242 CDS YP_905290.1 118616958 4554519 1351555..1353072 1 NC_008611.1 Detected in the membrane fraction by proteomics (2D- LC-MS/MS) Two isoforms were also detected in the cytoplasm.; membrane protein; hypothetical protein 1353072 4554519 MUL_1249 Mycobacterium ulcerans Agy99 hypothetical protein YP_905290.1 1351555 D 362242 CDS YP_905291.1 118616959 4554520 1353069..1354442 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; membrane protein; hypothetical protein 1354442 4554520 MUL_1250 Mycobacterium ulcerans Agy99 hypothetical protein YP_905291.1 1353069 D 362242 CDS YP_905292.1 118616960 4554522 1355342..1356115 1 NC_008611.1 secreted protein; hypothetical protein 1356115 4554522 MUL_1252 Mycobacterium ulcerans Agy99 hypothetical protein YP_905292.1 1355342 D 362242 CDS YP_905293.1 118616961 4554523 1356283..1356591 1 NC_008611.1 cytoplasmic protein; hypothetical protein 1356591 4554523 MUL_1253 Mycobacterium ulcerans Agy99 hypothetical protein YP_905293.1 1356283 D 362242 CDS YP_905294.1 118616962 4554524 complement(1356588..1359200) 1 NC_008611.1 membrane protein; metal cation-transporting ATPase; possibly catalyzes the transport of a undeterminated metal cation with the hydrolyse of ATP [catalytic activity: ATP + H(2)O + undeterminated metal cation(in) = ADP + phosphate + undeterminated metal cation(out)]; metal cation transporter p-type ATPase a 1359200 4554524 MUL_1254 Mycobacterium ulcerans Agy99 metal cation transporter p-type ATPase a YP_905294.1 1356588 R 362242 CDS YP_905295.1 118616963 4554525 1359441..1359968 1 NC_008611.1 cytoplasmic protein; hypothetical protein 1359968 4554525 MUL_1255 Mycobacterium ulcerans Agy99 hypothetical protein YP_905295.1 1359441 D 362242 CDS YP_905296.1 118616964 4554526 complement(1360070..1360504) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 1360504 4554526 MUL_1256 Mycobacterium ulcerans Agy99 hypothetical protein YP_905296.1 1360070 R 362242 CDS YP_905297.1 118616965 4552000 1361169..1361369 1 NC_008611.1 cytoplasmic protein; function unknown.; hypothetical protein 1361369 4552000 MUL_1259 Mycobacterium ulcerans Agy99 hypothetical protein YP_905297.1 1361169 D 362242 CDS YP_905298.1 118616966 4552001 1361754..1361861 1 NC_008611.1 cytoplasmic protein; hypothetical protein 1361861 4552001 MUL_1260 Mycobacterium ulcerans Agy99 hypothetical protein YP_905298.1 1361754 D 362242 CDS YP_905299.1 118616967 4552002 1362331..1363035 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; N-term transposase for IS2404 1363035 4552002 MUL_1261 Mycobacterium ulcerans Agy99 N-term transposase for IS2404 YP_905299.1 1362331 D 362242 CDS YP_905300.1 118616968 4552003 1363060..1363377 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; C-term transposase for IS2404 1363377 4552003 MUL_1262 Mycobacterium ulcerans Agy99 C-term transposase for IS2404 YP_905300.1 1363060 D 362242 CDS YP_905301.1 118616969 4552004 1363529..1364863 1 NC_008611.1 cytoplasmic protein; required for the transposition of the insertion element IS2606.; transposase for IS2606 1364863 4552004 MUL_1263 Mycobacterium ulcerans Agy99 transposase for IS2606 YP_905301.1 1363529 D 362242 CDS YP_905302.1 118616970 4552005 1365078..1365560 1 NC_008611.1 cytoplasmic protein; contains PTPS, 6-pyruvoyl tetrahydropterin synthase domain. 6-pyruvoyl tetrahydrobiopterin synthase catalyses the conversion of dihydroneopterin triphosphate to 6- pyruvoyl tetrahydropterin, the second of three enzymatic steps in the synthesis of tetrahydrobiopterin from GTP. the functional enzyme is a hexamer of identical subunits.; 6-pyruvoyl tetrahydrobiopterin synthase 1365560 4552005 MUL_1264 Mycobacterium ulcerans Agy99 6-pyruvoyl tetrahydrobiopterin synthase YP_905302.1 1365078 D 362242 CDS YP_905303.1 118616971 4552006 1366310..1367266 1 NC_008611.1 cytoplasmic protein; hypothetical protein 1367266 4552006 MUL_1265 Mycobacterium ulcerans Agy99 hypothetical protein YP_905303.1 1366310 D 362242 CDS YP_905304.1 118616972 4552007 1367290..1367745 1 NC_008611.1 cytoplasmic protein; hypothetical protein 1367745 4552007 MUL_1266 Mycobacterium ulcerans Agy99 hypothetical protein YP_905304.1 1367290 D 362242 CDS YP_905305.1 118616973 4552008 complement(1367771..1369105) 1 NC_008611.1 cytoplasmic protein; required for the transposition of the insertion element IS2606.; transposase for IS2606 1369105 4552008 MUL_1267 Mycobacterium ulcerans Agy99 transposase for IS2606 YP_905305.1 1367771 R 362242 CDS YP_905306.1 118616974 4552009 1369347..1370081 1 NC_008611.1 membrane protein; function unknown, predicted hydrolase (had superfamily) domain.; hypothetical protein 1370081 4552009 MUL_1268 Mycobacterium ulcerans Agy99 hypothetical protein YP_905306.1 1369347 D 362242 CDS YP_905307.1 118616975 4552010 1370187..1370921 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; function unknown, in general, cation channels are transport proteins responsible for the movement of cations through the membrane.; ion transport protein 1370921 4552010 MUL_1269 Mycobacterium ulcerans Agy99 ion transport protein YP_905307.1 1370187 D 362242 CDS YP_905308.1 118616976 4552011 complement(1370681..1371280) 1 NC_008611.1 Potential pseudogene due to a point mutation, removing a stop codon and now the CDS overlaps the C-term of a CDS on the opposite strand.; membrane protein; transmembrane protein 1371280 4552011 MUL_1270 Mycobacterium ulcerans Agy99 transmembrane protein YP_905308.1 1370681 R 362242 CDS YP_905309.1 118616977 4552012 complement(1371277..1371654) 1 NC_008611.1 membrane protein; transmembrane protein 1371654 4552012 MUL_1271 Mycobacterium ulcerans Agy99 transmembrane protein YP_905309.1 1371277 R 362242 CDS YP_905310.1 118616978 4552013 complement(1371853..1372251) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 1372251 4552013 MUL_1273 Mycobacterium ulcerans Agy99 hypothetical protein YP_905310.1 1371853 R 362242 CDS YP_905311.1 118616979 4552014 complement(1372248..1372781) 1 NC_008611.1 secreted protein; lipoprotein LppN 1372781 lppN 4552014 lppN Mycobacterium ulcerans Agy99 lipoprotein LppN YP_905311.1 1372248 R 362242 CDS YP_905312.1 118616980 4552015 complement(1372818..1373414) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 1373414 4552015 MUL_1275 Mycobacterium ulcerans Agy99 hypothetical protein YP_905312.1 1372818 R 362242 CDS YP_905313.1 118616981 4550118 complement(1374417..1374734) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; C-term transposase for IS2404 1374734 4550118 MUL_1277 Mycobacterium ulcerans Agy99 C-term transposase for IS2404 YP_905313.1 1374417 R 362242 CDS YP_905314.1 118616982 4550119 complement(1374759..1375463) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; N-term transposase for IS2404 1375463 4550119 MUL_1278 Mycobacterium ulcerans Agy99 N-term transposase for IS2404 YP_905314.1 1374759 R 362242 CDS YP_905315.1 118616983 4550120 1376289..1376915 1 NC_008611.1 cytoplasmic protein; hypothetical protein 1376915 4550120 MUL_1280 Mycobacterium ulcerans Agy99 hypothetical protein YP_905315.1 1376289 D 362242 CDS YP_905316.1 118616984 4550121 complement(1376924..1378297) 1 NC_008611.1 Also detected in the membrane fraction by proteomics (LC-MS/MS); cytoplasmic protein; possibly catalyzes the oxidative deamination: oxidize on primary amines, and perhaps on secondary and tertiary amines [catalytic activity: RCH(2)NH(2) + H(2)O + O(2) = RchO + NH(3) + H(2)O(2)] must have important function in metabolism. supposed involved in stationary- phase survival.; flavin-containing monoamine oxidase AofH_1 1378297 aofH_1 4550121 aofH_1 Mycobacterium ulcerans Agy99 flavin-containing monoamine oxidase AofH_1 YP_905316.1 1376924 R 362242 CDS YP_905317.1 118616985 4550122 complement(1378331..1379632) 1 NC_008611.1 cytoplasmic protein; cytochromes P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.; cytochrome P450 124A1, Cyp124A1 1379632 cyp124A1 4550122 cyp124A1 Mycobacterium ulcerans Agy99 cytochrome P450 124A1, Cyp124A1 YP_905317.1 1378331 R 362242 CDS YP_905318.1 118616986 4550126 complement(1383567..1383854) 1 NC_008611.1 cytoplasmic protein; function unknown.; hypothetical protein 1383854 4550126 MUL_1286 Mycobacterium ulcerans Agy99 hypothetical protein YP_905318.1 1383567 R 362242 CDS YP_905319.1 118616987 4550127 complement(1383949..1385019) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 1385019 4550127 MUL_1287 Mycobacterium ulcerans Agy99 hypothetical protein YP_905319.1 1383949 R 362242 CDS YP_905320.1 118616988 4550128 complement(1385057..1386010) 1 NC_008611.1 Detected in the membrane and cytoplamic fractions by proteomics.; cytoplasmic protein; oxidoreduction; short chain dehydrogenase 1386010 4550128 MUL_1288 Mycobacterium ulcerans Agy99 short chain dehydrogenase YP_905320.1 1385057 R 362242 CDS YP_905321.1 118616989 4550129 1386093..1387595 1 NC_008611.1 secreted protein; function unknown; thought to be involved in lipid metabolism.; hypothetical protein 1387595 4550129 MUL_1289 Mycobacterium ulcerans Agy99 hypothetical protein YP_905321.1 1386093 D 362242 CDS YP_905322.1 118616990 4550130 1387592..1388341 1 NC_008611.1 membrane protein; function unknown.; hypothetical protein 1388341 4550130 MUL_1290 Mycobacterium ulcerans Agy99 hypothetical protein YP_905322.1 1387592 D 362242 CDS YP_905323.1 118616991 4550131 complement(1388404..1389009) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 1389009 4550131 MUL_1291 Mycobacterium ulcerans Agy99 hypothetical protein YP_905323.1 1388404 R 362242 CDS YP_905324.1 118616992 4550132 complement(1389027..1390112) 1 NC_008611.1 Detected in the membrane fraction by proteomics (2D- LC-MS/MS); secreted protein; oxido-reduction; zinc-dependent alcohol dehydrogenase AdhE2 1390112 adhE2 4550132 adhE2 Mycobacterium ulcerans Agy99 zinc-dependent alcohol dehydrogenase AdhE2 YP_905324.1 1389027 R 362242 CDS YP_905325.1 118616993 4550133 1390243..1391313 1 NC_008611.1 cytoplasmic protein; possibly involved in transcriptional regulation; transcriptional regulatory protein 1391313 4550133 MUL_1293 Mycobacterium ulcerans Agy99 transcriptional regulatory protein YP_905325.1 1390243 D 362242 CDS YP_905326.1 118616994 4550134 1391326..1392144 1 NC_008611.1 cytoplasmic protein; hypothetical protein 1392144 4550134 MUL_1294 Mycobacterium ulcerans Agy99 hypothetical protein YP_905326.1 1391326 D 362242 CDS YP_905327.1 118616995 4550135 1392298..1392810 1 NC_008611.1 cytoplasmic protein; hypothetical protein 1392810 4550135 MUL_1295 Mycobacterium ulcerans Agy99 hypothetical protein YP_905327.1 1392298 D 362242 CDS YP_905328.1 118616996 4550710 complement(1393458..1394393) 1 NC_008611.1 involved in the biosynthesis of phosphatidylinositol mannosides (PIMs); the enzyme from Mycobacterium tuberculosis can phosphorylate a variety of amphipathic lipids; diacylglycerol kinase 1394393 4550710 MUL_1297 Mycobacterium ulcerans Agy99 diacylglycerol kinase YP_905328.1 1393458 R 362242 CDS YP_905329.1 118616997 4550711 complement(1394417..1395997) 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; electron acceptor; flavoprotein 1395997 4550711 MUL_1298 Mycobacterium ulcerans Agy99 flavoprotein YP_905329.1 1394417 R 362242 CDS YP_905330.1 118616998 4550712 1396045..1396614 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; possibly involved in transcriptional regulation; transcriptional regulatory protein 1396614 4550712 MUL_1299 Mycobacterium ulcerans Agy99 transcriptional regulatory protein YP_905330.1 1396045 D 362242 CDS YP_905331.1 118616999 4550713 1396614..1398149 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; involved in aerobic respiration and oxydation of glycerol. reduces an acceptor and generates glycerone phosphate from SN-glycerol 3-phosphate. possibly play a role in metabolism of riboflavin, fad,FMN [catalytic activity: SN-glycerol 3-phosphate + acceptor = glycerone phosphate + reduced acceptor]; glycerol-3-phosphate dehydrogenase GlpD1 1398149 glpD1 4550713 glpD1 Mycobacterium ulcerans Agy99 glycerol-3-phosphate dehydrogenase GlpD1 YP_905331.1 1396614 D 362242 CDS YP_905332.1 118617000 4550714 complement(1398230..1399045) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 1399045 4550714 MUL_1301 Mycobacterium ulcerans Agy99 hypothetical protein YP_905332.1 1398230 R 362242 CDS YP_905333.1 118617001 4550715 complement(1399243..1400664) 1 NC_008611.1 Detected in the membrane fraction by proteomics; membrane protein; involved in fatty acid biosynthesis (mycolic acids synthesis) [catalytic activity: ATP + propionyl-CoA + CO(2) + H(2)O = ADP + orthophosphate + methylmalonyl- CoA]; acetyl/propionyl-CoA carboxylase (beta subunit) AccD6 1400664 accD6 4550715 accD6 Mycobacterium ulcerans Agy99 acetyl/propionyl-CoA carboxylase (beta subunit) AccD6 YP_905333.1 1399243 R 362242 CDS YP_905334.1 118617002 4550716 complement(1400702..1401955) 1 NC_008611.1 FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-(acyl carrier protein) synthase II 1401955 kasB 4550716 kasB Mycobacterium ulcerans Agy99 3-oxoacyl-(acyl carrier protein) synthase II YP_905334.1 1400702 R 362242 CDS YP_905335.1 118617003 4550717 complement(1402037..1403287) 1 NC_008611.1 FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-(acyl carrier protein) synthase II 1403287 kasA 4550717 kasA Mycobacterium ulcerans Agy99 3-oxoacyl-(acyl carrier protein) synthase II YP_905335.1 1402037 R 362242 CDS YP_905336.1 118617004 4550718 complement(1403284..1403631) 1 NC_008611.1 carries the fatty acid chain in fatty acid biosynthesis; acyl carrier protein 1403631 acpP 4550718 acpP Mycobacterium ulcerans Agy99 acyl carrier protein YP_905336.1 1403284 R 362242 CDS YP_905337.1 118617005 4550719 complement(1403704..1404612) 1 NC_008611.1 membrane protein; catalyzes malonyl-CoA-acp transacylase (McaT) activity using holo-AcpM as substrate for transacylation [catalytic activity: malonyl-CoA + [acyl-carrier protein] = CoA + malonyl-[acyl-carrier protein]; malonyl CoA-acyl carrier protein transacylase FabD 1404612 fabD 4550719 fabD Mycobacterium ulcerans Agy99 malonyl CoA-acyl carrier protein transacylase FabD YP_905337.1 1403704 R 362242 CDS YP_905338.1 118617006 4550720 complement(1404774..1406084) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 1406084 4550720 MUL_1307 Mycobacterium ulcerans Agy99 hypothetical protein YP_905338.1 1404774 R 362242 CDS YP_905339.1 118617007 4550721 complement(1406218..1409007) 1 NC_008611.1 E1 component; part of pyruvate dehydrogenase; forms a complex with DlaT and LpdC; pyruvate dehydrogenase subunit E1 1409007 aceE 4550721 aceE Mycobacterium ulcerans Agy99 pyruvate dehydrogenase subunit E1 YP_905339.1 1406218 R 362242 CDS YP_905340.1 118617008 4550722 1409192..1409794 1 NC_008611.1 N-term truncated (missing first 69aa) wrt to M. tuberculosis; membrane protein; hypothetical protein 1409794 4550722 MUL_1309 Mycobacterium ulcerans Agy99 hypothetical protein YP_905340.1 1409192 D 362242 CDS YP_905341.1 118617009 4550723 1409851..1410297 1 NC_008611.1 cytoplasmic protein; hypothetical protein 1410297 4550723 MUL_1310 Mycobacterium ulcerans Agy99 hypothetical protein YP_905341.1 1409851 D 362242 CDS YP_905342.1 118617010 4550724 1410297..1410758 1 NC_008611.1 cytoplasmic protein; detoxification of organic peroxides.; peroxiredoxin AhpE 1410758 ahpE 4550724 ahpE Mycobacterium ulcerans Agy99 peroxiredoxin AhpE YP_905342.1 1410297 D 362242 CDS YP_905343.1 118617011 4550726 complement(1410897..1412447) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 1412447 4550726 MUL_1313 Mycobacterium ulcerans Agy99 hypothetical protein YP_905343.1 1410897 R 362242 CDS YP_905344.1 118617012 4551377 1413009..1413815 1 NC_008611.1 membrane protein; function unknown, possibly involved in transport of metal ions across the membrane.; hypothetical protein 1413815 4551377 MUL_1315 Mycobacterium ulcerans Agy99 hypothetical protein YP_905344.1 1413009 D 362242 CDS YP_905345.1 118617013 4551378 complement(1413836..1414651) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 1414651 4551378 MUL_1316 Mycobacterium ulcerans Agy99 hypothetical protein YP_905345.1 1413836 R 362242 CDS YP_905346.1 118617014 4551379 1414765..1415706 1 NC_008611.1 CobD; CbiD in Salmonella; converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group; cobalamin biosynthesis protein 1415706 cobD 4551379 cobD Mycobacterium ulcerans Agy99 cobalamin biosynthesis protein YP_905346.1 1414765 D 362242 CDS YP_905347.1 118617015 4551380 complement(1415688..1416512) 1 NC_008611.1 membrane protein; function unknown: may be involved in the ability to survive in macrophages.; transmembrane protein 1416512 4551380 MUL_1318 Mycobacterium ulcerans Agy99 transmembrane protein YP_905347.1 1415688 R 362242 CDS YP_905348.1 118617016 4551381 complement(1416512..1417006) 1 NC_008611.1 cytoplasmic protein; involved in signal transduction (via dephosphorylation) can dephosphorylated in vitro the phosphotyrosine residue of myelin basic protein (MBP) at ph 7.0 [catalytic activity: protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.; phosphotyrosine protein phosphatase PtpA 1417006 ptpA 4551381 ptpA Mycobacterium ulcerans Agy99 phosphotyrosine protein phosphatase PtpA YP_905348.1 1416512 R 362242 CDS YP_905349.1 118617017 4551382 complement(1416999..1417406) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 1417406 4551382 MUL_1320 Mycobacterium ulcerans Agy99 hypothetical protein YP_905349.1 1416999 R 362242 CDS YP_905350.1 118617018 4551383 1417906..1418961 1 NC_008611.1 cytoplasmic protein; involved in cobalamin biosynthesis; hypothetical protein 1418961 cobC 4551383 cobC Mycobacterium ulcerans Agy99 hypothetical protein YP_905350.1 1417906 D 362242 CDS YP_905351.1 118617019 4551384 1418958..1420094 1 NC_008611.1 cytoplasmic protein; hypothetical protein 1420094 4551384 MUL_1322 Mycobacterium ulcerans Agy99 hypothetical protein YP_905351.1 1418958 D 362242 CDS YP_905352.1 118617020 4551385 1420117..1420854 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; hypothetical protein 1420854 4551385 MUL_1323 Mycobacterium ulcerans Agy99 hypothetical protein YP_905352.1 1420117 D 362242 CDS YP_905353.1 118617021 4551386 1420851..1421975 1 NC_008611.1 cytoplasmic protein; bifunctional RNase H/acid phosphatase 1421975 4551386 MUL_1324 Mycobacterium ulcerans Agy99 bifunctional RNase H/acid phosphatase YP_905353.1 1420851 D 362242 CDS YP_905354.1 118617022 4551390 complement(1426446..1428038) 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS; cytoplasmic protein; hypothetical protein 1428038 4551390 MUL_1328 Mycobacterium ulcerans Agy99 hypothetical protein YP_905354.1 1426446 R 362242 CDS YP_905355.1 118617023 4551391 1428303..1428623 1 NC_008611.1 membrane protein; hypothetical protein 1428623 4551391 MUL_1329 Mycobacterium ulcerans Agy99 hypothetical protein YP_905355.1 1428303 D 362242 CDS YP_905356.1 118617024 4551392 complement(1428631..1429524) 1 NC_008611.1 catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate; 3-methyl-2-oxobutanoate hydroxymethyltransferase 1429524 panB 4551392 panB Mycobacterium ulcerans Agy99 3-methyl-2-oxobutanoate hydroxymethyltransferase YP_905356.1 1428631 R 362242 CDS YP_905357.1 118617025 4554072 1431122..1432678 1 NC_008611.1 secreted protein; function unknown; thought to hydrolyze peptides and/or proteins.; exported protease 1432678 4554072 MUL_1332 Mycobacterium ulcerans Agy99 exported protease YP_905357.1 1431122 D 362242 CDS YP_905358.1 118617026 4554073 1432822..1434558 1 NC_008611.1 membrane protein; cytochrome C oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. electrons originating in cytochrome C are transferred via the copper a center of subunit 2 and HemE a of subunit 1 to the bimetallic center formed by HemE A3 and copper B [catalytic activity: 4 ferrocytochrome C + O(2) = 2 H(2)O + 4 ferricytochrome C]; cytochrome C oxidase polypeptide I CtaD_1 1434558 ctaD_1 4554073 ctaD_1 Mycobacterium ulcerans Agy99 cytochrome C oxidase polypeptide I CtaD_1 YP_905358.1 1432822 D 362242 CDS YP_905359.1 118617027 4554074 1434619..1436187 1 NC_008611.1 secreted protein; function unknown; thought to hydrolyze peptides and/or proteins.; exported protease 1436187 4554074 MUL_1334 Mycobacterium ulcerans Agy99 exported protease YP_905359.1 1434619 D 362242 CDS YP_905360.1 118617028 4554075 1436277..1437617 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; involved in glutamine biosynthesis [catalytic activity: ATP + L-glutamate + NH(3) = ADP + glutamine + orthophosphate]; glutamine synthetase GlnA2 1437617 glnA2 4554075 glnA2 Mycobacterium ulcerans Agy99 glutamine synthetase GlnA2 YP_905360.1 1436277 D 362242 CDS YP_905361.1 118617029 4554076 1437688..1440675 1 NC_008611.1 catalyzes the ATP-dependent addition of AMP to a subunit of glutamine synthetase; also catalyzes the reverse reaction - deadenylation; adenylation/deadenylation of glutamine synthetase subunits is important for the regulation of this enzyme; bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase 1440675 glnE 4554076 glnE Mycobacterium ulcerans Agy99 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase YP_905361.1 1437688 D 362242 CDS YP_905362.1 118617030 4554078 1441534..1442181 1 NC_008611.1 cytoplasmic protein; function unknown, probably involved in cellular metabolism.; hypothetical protein 1442181 4554078 MUL_1338 Mycobacterium ulcerans Agy99 hypothetical protein YP_905362.1 1441534 D 362242 CDS YP_905363.1 118617031 4554079 complement(1442226..1444406) 1 NC_008611.1 membrane protein; function unknown. has fibronectin-binding activity (could thus mediate bacterial attachment to host cells) thought to be expressed during infection.; PE-PGRS family protein 1444406 4554079 MUL_1339 Mycobacterium ulcerans Agy99 PE-PGRS family protein YP_905363.1 1442226 R 362242 CDS YP_905364.1 118617032 4554080 complement(1444670..1446106) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); cytoplasmic protein; involved in glutamine biosynthesis [catalytic activity: ATP + L-glutamate + NH(3) = ADP + glutamine + orthophosphate]; glutamine synthetase GlnA1 1446106 glnA1 4554080 glnA1 Mycobacterium ulcerans Agy99 glutamine synthetase GlnA1 YP_905364.1 1444670 R 362242 CDS YP_905365.1 118617033 4554081 1446349..1446771 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; hypothetical protein 1446771 4554081 MUL_1341 Mycobacterium ulcerans Agy99 hypothetical protein YP_905365.1 1446349 D 362242 CDS YP_905366.1 118617034 4554082 complement(1446822..1447574) 1 NC_008611.1 membrane protein; transmembrane protein 1447574 4554082 MUL_1342 Mycobacterium ulcerans Agy99 transmembrane protein YP_905366.1 1446822 R 362242 CDS YP_905367.1 118617035 4554083 complement(1447602..1448576) 1 NC_008611.1 catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group; lipoyl synthase 1448576 lipA 4554083 lipA Mycobacterium ulcerans Agy99 lipoyl synthase YP_905367.1 1447602 R 362242 CDS YP_905368.1 118617036 4554084 complement(1448573..1449298) 1 NC_008611.1 lipoyl/octanoyltransferase; catalyzes the transfer of the lipoyl/octanoyl moiety of lipoyl/octanoyl-ACP onto lipoate-dependent enzymes like pyruvate dehydrogenase and the glycine cleavage system H protein; lipoate-protein ligase B 1449298 lipB 4554084 lipB Mycobacterium ulcerans Agy99 lipoate-protein ligase B YP_905368.1 1448573 R 362242 CDS YP_905369.1 118617037 4554085 1449570..1451300 1 NC_008611.1 membrane protein; thought to be involved in active transport of drugs across the membrane (export): multidrugs resistance by an export mechanism. responsible for energy coupling to the transport system and for the translocation of the substrate across the membrane.; drugs-transport transmembrane ATP-binding protein ABC transporter 1451300 4554085 MUL_1345 Mycobacterium ulcerans Agy99 drugs-transport transmembrane ATP-binding protein ABC transporter YP_905369.1 1449570 D 362242 CDS YP_905370.1 118617038 4554087 1453681..1454073 1 NC_008611.1 membrane protein; hypothetical protein 1454073 4554087 MUL_1347 Mycobacterium ulcerans Agy99 hypothetical protein YP_905370.1 1453681 D 362242 CDS YP_905371.1 118617039 4554088 complement(1454098..1455774) 1 NC_008611.1 membrane protein; involved in valine and isoleucine biosynthesis (at the first step) [catalytic activity: 2-acetolactate + CO(2) = 2 pyruvate]; acetolactate synthase (large subunit) IlvB1_2 1455774 ilvB1_2 4554088 ilvB1_2 Mycobacterium ulcerans Agy99 acetolactate synthase (large subunit) IlvB1_2 YP_905371.1 1454098 R 362242 CDS YP_905372.1 118617040 4554089 complement(1455774..1456433) 1 NC_008611.1 cytoplasmic protein; function unknown, may have methyltransferase activity; hypothetical protein 1456433 4554089 MUL_1349 Mycobacterium ulcerans Agy99 hypothetical protein YP_905372.1 1455774 R 362242 CDS YP_905373.1 118617041 4551949 complement(1457336..1458064) 1 NC_008611.1 cytoplasmic protein; multimeric flavodoxin WrbA 1458064 wrbA 4551949 wrbA Mycobacterium ulcerans Agy99 multimeric flavodoxin WrbA YP_905373.1 1457336 R 362242 CDS YP_905374.1 118617042 4551950 complement(1458615..1458842) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 1458842 4551950 MUL_1352 Mycobacterium ulcerans Agy99 hypothetical protein YP_905374.1 1458615 R 362242 CDS YP_905375.1 118617043 4551951 complement(1458889..1459476) 1 NC_008611.1 cytoplasmic protein; the sigma factor is an initiation factor that promotes attachment of the RNA polymerase to specific initiation sites and then is released.; alternative RNA polymerase sigma factor 1459476 4551951 MUL_1353 Mycobacterium ulcerans Agy99 alternative RNA polymerase sigma factor YP_905375.1 1458889 R 362242 CDS YP_905376.1 118617044 4551952 1459677..1460213 1 NC_008611.1 cytoplasmic protein; hypothetical protein 1460213 4551952 MUL_1354 Mycobacterium ulcerans Agy99 hypothetical protein YP_905376.1 1459677 D 362242 CDS YP_905377.1 118617045 4551953 complement(1460336..1460548) 1 NC_008611.1 secreted protein; hypothetical protein 1460548 4551953 MUL_1355 Mycobacterium ulcerans Agy99 hypothetical protein YP_905377.1 1460336 R 362242 CDS YP_905378.1 118617046 4551955 1462775..1464109 1 NC_008611.1 cytoplasmic protein; required for the transposition of the insertion element IS2606.; transposase for IS2606 1464109 4551955 MUL_1357 Mycobacterium ulcerans Agy99 transposase for IS2606 YP_905378.1 1462775 D 362242 CDS YP_905379.1 118617047 4551957 1466235..1467281 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 1467281 4551957 MUL_1359 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_905379.1 1466235 D 362242 CDS YP_905380.1 118617048 4551960 1469784..1471004 1 NC_008611.1 membrane protein; PE-PGRS family protein 1471004 4551960 MUL_1363 Mycobacterium ulcerans Agy99 PE-PGRS family protein YP_905380.1 1469784 D 362242 CDS YP_905381.1 118617049 4551961 complement(1471013..1472101) 1 NC_008611.1 catalyzes the formation of inosine from adenosine; adenosine deaminase 1472101 add 4551961 add Mycobacterium ulcerans Agy99 adenosine deaminase YP_905381.1 1471013 R 362242 CDS YP_905382.1 118617050 4552552 complement(1472098..1473399) 1 NC_008611.1 Catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate; thymidine phosphorylase 1473399 deoA 4552552 deoA Mycobacterium ulcerans Agy99 thymidine phosphorylase YP_905382.1 1472098 R 362242 CDS YP_905383.1 118617051 4552553 complement(1473396..1473794) 1 NC_008611.1 Reclaims exogenous and endogenous cytidine and 2'-deoxycytidine molecules for UMP synthesis; cytidine deaminase 1473794 cdd 4552553 cdd Mycobacterium ulcerans Agy99 cytidine deaminase YP_905383.1 1473396 R 362242 CDS YP_905384.1 118617052 4552554 1474082..1474420 1 NC_008611.1 membrane protein; involved in tricarboxylic acid cycle. mono-heme cytochrome of the succinate dehydrogenase complex.; succinate dehydrogenase (cytochrome B-556 subunit) SdhC 1474420 sdhC 4552554 sdhC Mycobacterium ulcerans Agy99 succinate dehydrogenase (cytochrome B-556 subunit) SdhC YP_905384.1 1474082 D 362242 CDS YP_905385.1 118617053 4552555 1474462..1474884 1 NC_008611.1 membrane protein; involved in tricarboxylic acid cycle. putative hydrophobic component of the succinate dehydrogenase complex. could be required to anchor the catalytic components to the cytoplasmic membrane.; succinate dehydrogenase (hydrophobic membrane anchor subunit) SdhD 1474884 sdhD 4552555 sdhD Mycobacterium ulcerans Agy99 succinate dehydrogenase (hydrophobic membrane anchor subunit) SdhD YP_905385.1 1474462 D 362242 CDS YP_905386.1 118617054 4552556 1474913..1476667 1 NC_008611.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; succinate dehydrogenase flavoprotein subunit 1476667 sdhA 4552556 sdhA Mycobacterium ulcerans Agy99 succinate dehydrogenase flavoprotein subunit YP_905386.1 1474913 D 362242 CDS YP_905387.1 118617055 4552557 1476673..1477479 1 NC_008611.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase; succinate dehydrogenase iron-sulfur subunit 1477479 sdhB 4552557 sdhB Mycobacterium ulcerans Agy99 succinate dehydrogenase iron-sulfur subunit YP_905387.1 1476673 D 362242 CDS YP_905388.1 118617056 4552558 complement(1477801..1478118) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; C-term transposase for IS2404 1478118 4552558 MUL_1371 Mycobacterium ulcerans Agy99 C-term transposase for IS2404 YP_905388.1 1477801 R 362242 CDS YP_905389.1 118617057 4552559 complement(1478143..1478847) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; N-term transposase for IS2404 1478847 4552559 MUL_1372 Mycobacterium ulcerans Agy99 N-term transposase for IS2404 YP_905389.1 1478143 R 362242 CDS YP_905390.1 118617058 4552560 complement(1479341..1479787) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; transmembrane protein 1479787 4552560 MUL_1373 Mycobacterium ulcerans Agy99 transmembrane protein YP_905390.1 1479341 R 362242 CDS YP_905391.1 118617059 4552561 complement(1479931..1480725) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); cytoplasmic protein; involved in base excision repair. apurinic- apyrimidinic endonuclease. supposed to remove the damaged DNA at cytosines and guanines by cleaving at the 3' side of the ap site by a beta-elimination reaction. possibly exhibites 3'-5'-exonuclease, 3'-phosphomonoesterase, 3'- repair diesterase and ribonuclease H activities [catalytic activity: degradation of double-stranded DNA. it acts progressively in a 3'- to 5'-direction, releasing 5'- phosphomononucleotides]; exodeoxyribonuclease III protein XthA 1480725 xthA 4552561 xthA Mycobacterium ulcerans Agy99 exodeoxyribonuclease III protein XthA YP_905391.1 1479931 R 362242 CDS YP_905392.1 118617060 4552563 complement(1481661..1482254) 1 NC_008611.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+); peptide deformylase 1482254 def 4552563 def Mycobacterium ulcerans Agy99 peptide deformylase YP_905392.1 1481661 R 362242 CDS YP_905393.1 118617061 4552564 1482288..1482812 1 NC_008611.1 cytoplasmic protein; hypothetical protein 1482812 4552564 MUL_1377 Mycobacterium ulcerans Agy99 hypothetical protein YP_905393.1 1482288 D 362242 CDS YP_905394.1 118617062 4552565 1482868..1483359 1 NC_008611.1 Detected in the membrane fraction and secreted fractions by proteomics. (2D-LC-MS/MS); membrane protein; tuberculin related peptide 1483359 4552565 MUL_1378 Mycobacterium ulcerans Agy99 tuberculin related peptide YP_905394.1 1482868 D 362242 CDS YP_905395.1 118617063 4552566 1483432..1484148 1 NC_008611.1 Detected in the membrane fraction by proteomics; secreted protein; destroys radicals which are normally produced within the cells and are toxic to biological systems [catalytic activity: 2 superoxide + 2 H+ = O2 + H2O2]; periplasmic superoxide dismutase [Cu-Zn] SodC 1484148 sodC 4552566 sodC Mycobacterium ulcerans Agy99 periplasmic superoxide dismutase [Cu-Zn] SodC YP_905395.1 1483432 D 362242 CDS YP_905396.1 118617064 4552567 1484102..1485280 1 NC_008611.1 ATP-dependent carboxylate-amine ligase; carboxylate-amine ligase 1485280 4552567 MUL_1380 Mycobacterium ulcerans Agy99 carboxylate-amine ligase YP_905396.1 1484102 D 362242 CDS YP_905397.1 118617065 4552568 complement(1485385..1486047) 1 NC_008611.1 cytoplasmic protein; involved in transcriptional mechanism.; GntR family transcriptional regulator 1486047 4552568 MUL_1381 Mycobacterium ulcerans Agy99 GntR family transcriptional regulator YP_905397.1 1485385 R 362242 CDS YP_905398.1 118617066 4552569 1486184..1487470 1 NC_008611.1 membrane protein; function unknown, possibly involved in inorganic ion transport.; MFS transporter 1487470 4552569 MUL_1382 Mycobacterium ulcerans Agy99 MFS transporter YP_905398.1 1486184 D 362242 CDS YP_905399.1 118617067 4552570 1487608..1488264 1 NC_008611.1 cytoplasmic protein; hypothetical protein 1488264 4552570 MUL_1383 Mycobacterium ulcerans Agy99 hypothetical protein YP_905399.1 1487608 D 362242 CDS YP_905400.1 118617068 4552534 complement(1488271..1490448) 1 NC_008611.1 membrane protein; ATPase; possibly catalyzes the transport of undeterminated substrate with hydrolyse of ATP [catalytic activity: ATP + H(2)O + undeterminated substrate(in) = ADP + phosphate + undeterminated substrate(out)]; ATPase 1490448 4552534 MUL_1384 Mycobacterium ulcerans Agy99 ATPase YP_905400.1 1488271 R 362242 CDS YP_905401.1 118617069 4552535 complement(1490445..1491320) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; involved in phospholipid biosynthesis. generates phosphatidylserine [catalytic activity: CDP-diacylglycerol + L-serine = CMP + O-SN-phosphatidyl-L-serine]; CDP-diacylglycerol--serine o- phosphatidyltransferase PssA 1491320 pssA 4552535 pssA Mycobacterium ulcerans Agy99 CDP-diacylglycerol--serine o- phosphatidyltransferase PssA YP_905401.1 1490445 R 362242 CDS YP_905402.1 118617070 4552536 complement(1491317..1492039) 1 NC_008611.1 catalyzes the decarboxylaton of phospatidyl-L-sering to phosphatidylethanolamine; phosphatidylserine decarboxylase 1492039 psd 4552536 psd Mycobacterium ulcerans Agy99 phosphatidylserine decarboxylase YP_905402.1 1491317 R 362242 CDS YP_905403.1 118617071 4552538 complement(1494204..1495250) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 1495250 4552538 MUL_1388 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_905403.1 1494204 R 362242 CDS YP_905404.1 118617072 4552539 complement(1495965..1497182) 1 NC_008611.1 cytoplasmic protein; involved in molybdenum cofactor biosynthesis: involved in the biosynthesis of a demolybdo-cofactor (molybdopterin), necessary for molybdo-enzymes (by similarity); molybdopterin biosynthesis protein MoeA2 1497182 moeA2 4552539 moeA2 Mycobacterium ulcerans Agy99 molybdopterin biosynthesis protein MoeA2 YP_905404.1 1495965 R 362242 CDS YP_905405.1 118617073 4552540 complement(1497201..1498139) 1 NC_008611.1 cytoplasmic protein; function unknown, possibly involved in cellular metabolism.; short chain dehydrogenase 1498139 4552540 MUL_1391 Mycobacterium ulcerans Agy99 short chain dehydrogenase YP_905405.1 1497201 R 362242 CDS YP_905406.1 118617074 4552541 complement(1498186..1498707) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 1498707 4552541 MUL_1392 Mycobacterium ulcerans Agy99 hypothetical protein YP_905406.1 1498186 R 362242 CDS YP_905407.1 118617075 4552542 1498999..1500624 1 NC_008611.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth; chaperonin GroEL 1500624 groEL 4552542 groEL Mycobacterium ulcerans Agy99 chaperonin GroEL YP_905407.1 1498999 D 362242 CDS YP_905408.1 118617076 4552543 complement(1500708..1501127) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 1501127 4552543 MUL_1394 Mycobacterium ulcerans Agy99 hypothetical protein YP_905408.1 1500708 R 362242 CDS YP_905409.1 118617077 4552544 complement(1501164..1502636) 1 NC_008611.1 PPE10; membrane protein; PPE family protein 1502636 4552544 MUL_1395 Mycobacterium ulcerans Agy99 PPE family protein YP_905409.1 1501164 R 362242 CDS YP_905410.1 118617078 4552545 complement(1502732..1504444) 1 NC_008611.1 cytoplasmic protein; hydrolizes a specific D-amino acid.; D-amino acid aminohydrolase 1504444 4552545 MUL_1396 Mycobacterium ulcerans Agy99 D-amino acid aminohydrolase YP_905410.1 1502732 R 362242 CDS YP_905411.1 118617079 4552546 1504547..1505062 1 NC_008611.1 cytoplasmic protein; hypothetical protein 1505062 4552546 MUL_1397 Mycobacterium ulcerans Agy99 hypothetical protein YP_905411.1 1504547 D 362242 CDS YP_905412.1 118617080 4552547 1505126..1505920 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; hypothetical protein 1505920 4552547 MUL_1398 Mycobacterium ulcerans Agy99 hypothetical protein YP_905412.1 1505126 D 362242 CDS YP_905413.1 118617081 4552548 complement(1505932..1506630) 1 NC_008611.1 membrane protein; hypothetical protein 1506630 4552548 MUL_1399 Mycobacterium ulcerans Agy99 hypothetical protein YP_905413.1 1505932 R 362242 CDS YP_905414.1 118617082 4552549 complement(1506627..1507190) 1 NC_008611.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; in M. bovis this protein has been shown to be involved in expression of antigenic proteins; RNA polymerase sigma factor SigK 1507190 sigK 4552549 sigK Mycobacterium ulcerans Agy99 RNA polymerase sigma factor SigK YP_905414.1 1506627 R 362242 CDS YP_905415.1 118617083 4552550 complement(1507236..1508009) 1 NC_008611.1 membrane protein; transmembrane protein 1508009 4552550 MUL_1401 Mycobacterium ulcerans Agy99 transmembrane protein YP_905415.1 1507236 R 362242 CDS YP_905416.1 118617084 4552551 complement(1508027..1509313) 1 NC_008611.1 cytoplasmic protein; transfers a methylene group from S-adenosyl-L- methionine to the cis double bond of an unsaturated fatty acid chain resulting in the replacement of the double bond with a methylene bridge [catalytic activity: S-adenosyl-L- methionine + phospholipid olefinic fatty acid = S-adenosyl- L-homocysteine + phospholipid cyclopropane fatty acid]; cyclopropane-fatty-acyl-phospholipid synthase UfaA1 1509313 ufaA1 4552551 ufaA1 Mycobacterium ulcerans Agy99 cyclopropane-fatty-acyl-phospholipid synthase UfaA1 YP_905416.1 1508027 R 362242 CDS YP_905417.1 118617085 4552518 complement(1509310..1509954) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 1509954 4552518 MUL_1403 Mycobacterium ulcerans Agy99 hypothetical protein YP_905417.1 1509310 R 362242 CDS YP_905418.1 118617086 4552519 complement(1510020..1511336) 1 NC_008611.1 membrane protein; oxidoreductase 1511336 4552519 MUL_1404 Mycobacterium ulcerans Agy99 oxidoreductase YP_905418.1 1510020 R 362242 CDS YP_905419.1 118617087 4552521 1512229..1513563 1 NC_008611.1 cytoplasmic protein; required for the transposition of the insertion element IS2606.; transposase for IS2606 1513563 4552521 MUL_1406 Mycobacterium ulcerans Agy99 transposase for IS2606 YP_905419.1 1512229 D 362242 CDS YP_905420.1 118617088 4552522 1513923..1514627 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; N-term transposase for IS2404 1514627 4552522 MUL_1407 Mycobacterium ulcerans Agy99 N-term transposase for IS2404 YP_905420.1 1513923 D 362242 CDS YP_905421.1 118617089 4552523 1514652..1514969 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; C-term transposase for IS2404 1514969 4552523 MUL_1408 Mycobacterium ulcerans Agy99 C-term transposase for IS2404 YP_905421.1 1514652 D 362242 CDS YP_905422.1 118617090 4552525 complement(1515962..1517296) 1 NC_008611.1 cytoplasmic protein; required for the transposition of the insertion element IS2606.; transposase for IS2606 1517296 4552525 MUL_1410 Mycobacterium ulcerans Agy99 transposase for IS2606 YP_905422.1 1515962 R 362242 CDS YP_905423.1 118617091 4552526 complement(1518095..1518442) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 1518442 4552526 MUL_1411 Mycobacterium ulcerans Agy99 hypothetical protein YP_905423.1 1518095 R 362242 CDS YP_905424.1 118617092 4552527 complement(1518718..1519167) 1 NC_008611.1 Detected in the secreted protein fraction by 2D-LC- MS/MS.; secreted protein; hypothetical protein 1519167 4552527 MUL_1413 Mycobacterium ulcerans Agy99 hypothetical protein YP_905424.1 1518718 R 362242 CDS YP_905425.1 118617093 4552528 complement(1519234..1520148) 1 NC_008611.1 catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 1520148 echA2 4552528 echA2 Mycobacterium ulcerans Agy99 enoyl-CoA hydratase YP_905425.1 1519234 R 362242 CDS YP_905426.1 118617094 4552530 1522423..1523946 1 NC_008611.1 cytoplasmic protein; interconversion aldehyde and acid [catalytic activity: an aldehyde + NAD+ + H2O = an acid + NADH]; aldehyde dehydrogenase 1523946 4552530 MUL_1416 Mycobacterium ulcerans Agy99 aldehyde dehydrogenase YP_905426.1 1522423 D 362242 CDS YP_905427.1 118617095 4552531 1523946..1524446 1 NC_008611.1 cytoplasmic protein; hypothetical protein 1524446 4552531 MUL_1417 Mycobacterium ulcerans Agy99 hypothetical protein YP_905427.1 1523946 D 362242 CDS YP_905428.1 118617096 4552532 1524506..1524745 1 NC_008611.1 membrane protein; hypothetical protein 1524745 4552532 MUL_1418 Mycobacterium ulcerans Agy99 hypothetical protein YP_905428.1 1524506 D 362242 CDS YP_905429.1 118617097 4552533 1524738..1525307 1 NC_008611.1 membrane protein; transmembrane protein 1525307 4552533 MUL_1419 Mycobacterium ulcerans Agy99 transmembrane protein YP_905429.1 1524738 D 362242 CDS YP_905430.1 118617098 4552486 1525894..1526940 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 1526940 4552486 MUL_1421 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_905430.1 1525894 D 362242 CDS YP_905431.1 118617099 4552488 1527708..1528973 1 NC_008611.1 cytoplasmic protein; function unknown, probably involved in cellular metabolism.; dehydrogenase 1528973 4552488 MUL_1423 Mycobacterium ulcerans Agy99 dehydrogenase YP_905431.1 1527708 D 362242 CDS YP_905432.1 118617100 4552489 complement(1529017..1531545) 1 NC_008611.1 membrane protein; thought to be involved in active transport of undeterminated substrate (possibly lipooligosaccharide) across the membrane. responsible for energy coupling to the transport system and for the translocation of the substrate across the membrane.; transmembrane ATP-binding protein ABC transporter 1531545 4552489 MUL_1424 Mycobacterium ulcerans Agy99 transmembrane ATP-binding protein ABC transporter YP_905432.1 1529017 R 362242 CDS YP_905433.1 118617101 4552492 1535863..1536708 1 NC_008611.1 catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate; bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase 1536708 folD 4552492 folD Mycobacterium ulcerans Agy99 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase YP_905433.1 1535863 D 362242 CDS YP_905434.1 118617102 4552493 1536705..1536998 1 NC_008611.1 membrane protein; hypothetical protein 1536998 4552493 MUL_1429 Mycobacterium ulcerans Agy99 hypothetical protein YP_905434.1 1536705 D 362242 CDS YP_905435.1 118617103 4552494 complement(1537002..1537418) 1 NC_008611.1 Detected in the secreted fraction by proteomics.; secreted protein; hypothetical protein 1537418 4552494 MUL_1430 Mycobacterium ulcerans Agy99 hypothetical protein YP_905435.1 1537002 R 362242 CDS YP_905436.1 118617104 4552495 1537672..1539114 1 NC_008611.1 secreted protein; function unknown, probably involved in cellular metabolism.; oxidoreductase 1539114 4552495 MUL_1431 Mycobacterium ulcerans Agy99 oxidoreductase YP_905436.1 1537672 D 362242 CDS YP_905437.1 118617105 4552496 1539362..1541206 1 NC_008611.1 activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 1541206 fadD28_1 4552496 fadD28_1 Mycobacterium ulcerans Agy99 acyl-CoA synthetase YP_905437.1 1539362 D 362242 CDS YP_905438.1 118617106 4552498 complement(1549194..1549490) 1 NC_008611.1 secreted protein; hypothetical protein 1549490 4552498 MUL_1434 Mycobacterium ulcerans Agy99 hypothetical protein YP_905438.1 1549194 R 362242 CDS YP_905439.1 118617107 4552499 complement(1549552..1549899) 1 NC_008611.1 secreted protein; exported protein 1549899 4552499 MUL_1435 Mycobacterium ulcerans Agy99 exported protein YP_905439.1 1549552 R 362242 CDS YP_905440.1 118617108 4552500 complement(1550039..1550776) 1 NC_008611.1 cytoplasmic protein; causes methylation; methyltransferase 1550776 4552500 MUL_1436 Mycobacterium ulcerans Agy99 methyltransferase YP_905440.1 1550039 R 362242 CDS YP_905441.1 118617109 4552501 complement(1550770..1551909) 1 NC_008611.1 Catalyzes the conversion of acetyl-CoA and L-homoserine to CoA and O-acetyl-L-homoserine; homoserine O-acetyltransferase 1551909 metX 4552501 metX Mycobacterium ulcerans Agy99 homoserine O-acetyltransferase YP_905441.1 1550770 R 362242 CDS YP_905442.1 118617110 4552502 complement(1551921..1553270) 1 NC_008611.1 catalyzes the formation of L-methionine and acetate from O-acetyl-L-homoserine and methanethiol; O-acetylhomoserine aminocarboxypropyltransferase 1553270 metC 4552502 metC Mycobacterium ulcerans Agy99 O-acetylhomoserine aminocarboxypropyltransferase YP_905442.1 1551921 R 362242 CDS YP_905443.1 118617111 4552470 complement(1554837..1555538) 1 NC_008611.1 membrane protein; hypothetical protein 1555538 4552470 MUL_1440 Mycobacterium ulcerans Agy99 hypothetical protein YP_905443.1 1554837 R 362242 CDS YP_905444.1 118617112 4552471 1555795..1556814 1 NC_008611.1 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; tryptophanyl-tRNA synthetase 1556814 trpS 4552471 trpS Mycobacterium ulcerans Agy99 tryptophanyl-tRNA synthetase YP_905444.1 1555795 D 362242 CDS YP_905445.1 118617113 4552472 1556819..1557847 1 NC_008611.1 membrane protein; integral membrane protein 1557847 4552472 MUL_1442 Mycobacterium ulcerans Agy99 integral membrane protein YP_905445.1 1556819 D 362242 CDS YP_905446.1 118617114 4552473 complement(1557844..1559010) 1 NC_008611.1 membrane protein; involved in N-acetyl glucosamine utilization pathway [catalytic activity: N-acetyl-D-glucosamine 6- phosphate + H(2)O = D-glucosamine 6-phosphate + acetate]; n-acetylglucosamine-6-phosphate deacetylase NagA 1559010 nagA 4552473 nagA Mycobacterium ulcerans Agy99 n-acetylglucosamine-6-phosphate deacetylase NagA YP_905446.1 1557844 R 362242 CDS YP_905447.1 118617115 4552474 complement(1559007..1560356) 1 NC_008611.1 membrane protein; thought to be involved in transport of sugar across the membrane. responsible for the translocation of the substrate across the membrane.; sugar-transport integral membrane protein SugI 1560356 sugI 4552474 sugI Mycobacterium ulcerans Agy99 sugar-transport integral membrane protein SugI YP_905447.1 1559007 R 362242 CDS YP_905448.1 118617116 4552475 complement(1560558..1561805) 1 NC_008611.1 secreted protein; involved in peptidoglycan synthesis (at final stages) hydrolyzes the bound D-alanyl-D-alanine [catalytic activity: D-alanyl-D-alanine + H(2)O = 2 D- alanine]; penicillin-binding protein DacC 1561805 dacC 4552475 dacC Mycobacterium ulcerans Agy99 penicillin-binding protein DacC YP_905448.1 1560558 R 362242 CDS YP_905449.1 118617117 4552476 1561927..1562565 1 NC_008611.1 secreted protein; hypothetical protein 1562565 4552476 MUL_1446 Mycobacterium ulcerans Agy99 hypothetical protein YP_905449.1 1561927 D 362242 CDS YP_905450.1 118617118 4552477 1562672..1564873 1 NC_008611.1 cytoplasmic protein; possible inter-alpha-trypsin inhibitor family heavy chain-related protein-hypothetical secreted or membrane- associated protein containing vWFA domain.; hypothetical protein 1564873 4552477 MUL_1447 Mycobacterium ulcerans Agy99 hypothetical protein YP_905450.1 1562672 D 362242 CDS YP_905451.1 118617119 4552480 1567392..1568603 1 NC_008611.1 membrane protein; PE-PGRS family protein 1568603 4552480 MUL_1450 Mycobacterium ulcerans Agy99 PE-PGRS family protein YP_905451.1 1567392 D 362242 CDS YP_905452.1 118617120 4552484 complement(1571380..1572426) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 1572426 4552484 MUL_1454 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_905452.1 1571380 R 362242 CDS YP_905453.1 118617121 4552453 1572858..1573154 1 NC_008611.1 Detected in the cytoplasmic and membrane fractions by 2D-LC-MS/MS.; secreted protein; EsaT-6 like protein EsxP_1 1573154 esxP_1 4552453 esxP_1 Mycobacterium ulcerans Agy99 EsaT-6 like protein EsxP_1 YP_905453.1 1572858 D 362242 CDS YP_905454.1 118617122 4552454 1573217..1573501 1 NC_008611.1 Also detected in the cytoplasmic fraction by 2D-LC- MS/MS.; secreted protein; EsaT-6 like protein EsxN_1 1573501 esxN_1 4552454 esxN_1 Mycobacterium ulcerans Agy99 EsaT-6 like protein EsxN_1 YP_905454.1 1573217 D 362242 CDS YP_905455.1 118617123 4552456 1575842..1577119 1 NC_008611.1 dGTPase family type 2 subfamily; presumably hydrolyzes dGTP to deoxyguanosine and triphosphate; deoxyguanosinetriphosphate triphosphohydrolase-like protein 1577119 dgt 4552456 dgt Mycobacterium ulcerans Agy99 deoxyguanosinetriphosphate triphosphohydrolase-like protein YP_905455.1 1575842 D 362242 CDS YP_905456.1 118617124 4552457 1577161..1579131 1 NC_008611.1 synthesizes RNA primers at the replication forks; DNA primase 1579131 dnaG 4552457 dnaG Mycobacterium ulcerans Agy99 DNA primase YP_905456.1 1577161 D 362242 CDS YP_905457.1 118617125 4552458 complement(1579146..1579391) 1 NC_008611.1 hypothetical protein 1579391 4552458 MUL_1460 Mycobacterium ulcerans Agy99 hypothetical protein YP_905457.1 1579146 R 362242 CDS YP_905458.1 118617126 4552460 complement(1579758..1580210) 1 NC_008611.1 secreted protein; function unknown, contains N-term signal peptide indicative of secreted protein.; hypothetical protein 1580210 4552460 MUL_1462 Mycobacterium ulcerans Agy99 hypothetical protein YP_905458.1 1579758 R 362242 CDS YP_905459.1 118617127 4552461 complement(1580238..1580666) 1 NC_008611.1 secreted protein; thioredoxin participates in various redox reactions through the reversible oxidation of its active center dithiol, to a disulfide, & catalyzes dithiol-disulfide exchange reactions.; thioredoxin ThiX 1580666 thiX 4552461 thiX Mycobacterium ulcerans Agy99 thioredoxin ThiX YP_905459.1 1580238 R 362242 CDS YP_905460.1 118617128 4552462 complement(1580677..1581363) 1 NC_008611.1 cytoplasmic protein; involved in cysteine biosynthesis [catalytic activity: acetyl-CoA + L-serine = CoA + O-acetyl-L- serine]; serine acetyltransferase CysE 1581363 cysE 4552462 cysE Mycobacterium ulcerans Agy99 serine acetyltransferase CysE YP_905460.1 1580677 R 362242 CDS YP_905461.1 118617129 4552463 complement(1581366..1582298) 1 NC_008611.1 Also detected in the membrane fraction by proteomics.; cytoplasmic protein; involved in cysteine biosynthesis [catalytic activity: O3-acetyl-L-serine + H(2)S = L-cysteine + acetate]; cysteine synthase a CysK1 1582298 cysK1 4552463 cysK1 Mycobacterium ulcerans Agy99 cysteine synthase a CysK1 YP_905461.1 1581366 R 362242 CDS YP_905462.1 118617130 4552464 complement(1582295..1582711) 1 NC_008611.1 hypothetical protein 1582711 4552464 MUL_1466 Mycobacterium ulcerans Agy99 hypothetical protein YP_905462.1 1582295 R 362242 CDS YP_905463.1 118617131 4552465 complement(1583019..1584665) 1 NC_008611.1 malic enzyme; oxaloacetate-decarboxylating; NAD-dependent; catalyzes the formation of pyruvate form malate; malate dehydrogenase 1584665 mez 4552465 mez Mycobacterium ulcerans Agy99 malate dehydrogenase YP_905463.1 1583019 R 362242 CDS YP_905464.1 118617132 4552466 1585082..1585987 1 NC_008611.1 membrane protein; thought to be involved in a transport system across the membrane (perhaps drug transport): responsible for the translocation of the substrate across the membrane.; integral membrane transport protein 1585987 4552466 MUL_1468 Mycobacterium ulcerans Agy99 integral membrane transport protein YP_905464.1 1585082 D 362242 CDS YP_905465.1 118617133 4552467 1586263..1587309 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 1587309 4552467 MUL_1469 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_905465.1 1586263 D 362242 CDS YP_905466.1 118617134 4552433 1587623..1588957 1 NC_008611.1 cytoplasmic protein; required for the transposition of the insertion element IS2606.; transposase for IS2606 1588957 4552433 MUL_1471 Mycobacterium ulcerans Agy99 transposase for IS2606 YP_905466.1 1587623 D 362242 CDS YP_905467.1 118617135 4552434 complement(1590742..1592343) 1 NC_008611.1 membrane protein; thought to play an essential roles in regulation of cellular metabolism by catalysing the synthesis of a second messenger, camp [catalytic activity: ATP = 3',5'- cyclic AMP + pyrophosphate]; adenylate cyclase 1592343 4552434 MUL_1472 Mycobacterium ulcerans Agy99 adenylate cyclase YP_905467.1 1590742 R 362242 CDS YP_905468.1 118617136 4552435 complement(1592995..1597203) 1 NC_008611.1 cytoplasmic protein; decomposes formic acid to hydrogen and carbon dioxide under anaerobic conditions in the absence of exogenous electron acceptors [catalytic activity: formate + NAD(+) = CO(2) + NADH]; formate dehydrogenase H FdhF 1597203 fdhF 4552435 fdhF Mycobacterium ulcerans Agy99 formate dehydrogenase H FdhF YP_905468.1 1592995 R 362242 CDS YP_905469.1 118617137 4552436 1597621..1598124 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; lipoprotein LppP 1598124 lppP 4552436 lppP Mycobacterium ulcerans Agy99 lipoprotein LppP YP_905469.1 1597621 D 362242 CDS YP_905470.1 118617138 4552438 1598916..1600895 1 NC_008611.1 membrane protein; cation-transporting ATPase; possibly catalyzes the transport of a cation (possibly cadmium) with the hydrolyse of ATP [catalytic activity: ATP + H(2)O + cation(in) = ADP + phosphate + cation(out)]; cation transporter p-type ATPase D CtpD 1600895 ctpD 4552438 ctpD Mycobacterium ulcerans Agy99 cation transporter p-type ATPase D CtpD YP_905470.1 1598916 D 362242 CDS YP_905471.1 118617139 4552439 1600990..1601346 1 NC_008611.1 cytoplasmic protein; thioredoxin participates in various redox reactions through the reversible oxidation of its active center dithiol, to a disulfide, & catalyzes dithiol-disulfide exchange reactions.; thioredoxin TrxA 1601346 trxA 4552439 trxA Mycobacterium ulcerans Agy99 thioredoxin TrxA YP_905471.1 1600990 D 362242 CDS YP_905472.1 118617140 4552440 1601432..1601761 1 NC_008611.1 cytoplasmic protein; thioredoxin participates in various redox reactions through the reversible oxidation of its active center dithiol, to a disulfide, & catalyzes dithiol-disulfide exchange reactions.; thioredoxin TrxB1 1601761 trxB1 4552440 trxB1 Mycobacterium ulcerans Agy99 thioredoxin TrxB1 YP_905472.1 1601432 D 362242 CDS YP_905473.1 118617141 4552441 1601845..1602654 1 NC_008611.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 1602654 echA12 4552441 echA12 Mycobacterium ulcerans Agy99 enoyl-CoA hydratase YP_905473.1 1601845 D 362242 CDS YP_905474.1 118617142 4552442 1602679..1604307 1 NC_008611.1 membrane protein; probable macrolide-transport ATP-binding protein ABC transporter. thought to be involved in active transport of macrolide across the membrane.; ATP-binding protein ABC transporter 1604307 4552442 MUL_1481 Mycobacterium ulcerans Agy99 ATP-binding protein ABC transporter YP_905474.1 1602679 D 362242 CDS YP_905475.1 118617143 4552443 1604392..1604583 1 NC_008611.1 cytoplasmic protein; involved in transcriptional mechanism.; transcriptional regulatory protein 1604583 4552443 MUL_1482 Mycobacterium ulcerans Agy99 transcriptional regulatory protein YP_905475.1 1604392 D 362242 CDS YP_905476.1 118617144 4552444 complement(1604585..1605148) 1 NC_008611.1 cytoplasmic protein; involved in transcriptional mechanism.; transcriptional regulatory protein 1605148 4552444 MUL_1483 Mycobacterium ulcerans Agy99 transcriptional regulatory protein YP_905476.1 1604585 R 362242 CDS YP_905477.2 162138271 4552445 complement(1605158..1607977) 1 NC_008611.1 Catalyzes the conversion of citrate to isocitrate; aconitate hydratase 1607977 acn 4552445 acn Mycobacterium ulcerans Agy99 aconitate hydratase YP_905477.2 1605158 R 362242 CDS YP_905478.1 118617146 4552446 1608253..1608831 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; hypothetical protein 1608831 4552446 MUL_1485 Mycobacterium ulcerans Agy99 hypothetical protein YP_905478.1 1608253 D 362242 CDS YP_905479.1 118617147 4552447 1609063..1610472 1 NC_008611.1 secreted protein; function unknown, similar to a hypothetical invasion protein. possibly an exported protein with unusually long signal sequence. NLP/P60 family protein; cell wall-associated hydrolase 1610472 4552447 MUL_1486 Mycobacterium ulcerans Agy99 cell wall-associated hydrolase YP_905479.1 1609063 D 362242 CDS YP_905480.1 118617148 4552448 1610498..1611217 1 NC_008611.1 secreted protein; function unknown. homology to cell wall-associated hydrolases. possibly an exported protein of the NLP/P60 family.; invasion protein Inv2 1611217 inv2 4552448 inv2 Mycobacterium ulcerans Agy99 invasion protein Inv2 YP_905480.1 1610498 D 362242 CDS YP_905481.1 118617149 4552449 1611416..1612531 1 NC_008611.1 Detected in the cytoplamic and membrane fractions by LC-MS/MS. Also detected in the extracellular matrix by proteomics.; membrane protein; involved in transcriptional mechanism.; transcriptional regulatory protein, MoxR1 1612531 moxR1 4552449 moxR1 Mycobacterium ulcerans Agy99 transcriptional regulatory protein, MoxR1 YP_905481.1 1611416 D 362242 CDS YP_905482.1 118617150 4552450 1612546..1613502 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; hypothetical protein 1613502 4552450 MUL_1489 Mycobacterium ulcerans Agy99 hypothetical protein YP_905482.1 1612546 D 362242 CDS YP_905483.1 118617151 4552451 1613537..1614544 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; hypothetical protein 1614544 4552451 MUL_1490 Mycobacterium ulcerans Agy99 hypothetical protein YP_905483.1 1613537 D 362242 CDS YP_905484.1 118617152 4552452 1614659..1615426 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS) Also detected in the cytoplasmic fraction by 2D-LC- MS/MS.; membrane protein; involved in the fatty acid biosynthesis pathway (first reduction step) (mycolic acid biosynthesis); reduces KasA/KasB products [catalytic activity: (3R)-3- hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl- [acyl-carrier protein] + NADPH]; 3-oxoacyl-[acyl-carrier protein] reductase, FabG1 1615426 fabG1 4552452 fabG1 Mycobacterium ulcerans Agy99 3-oxoacyl-[acyl-carrier protein] reductase, FabG1 YP_905484.1 1614659 D 362242 CDS YP_905485.1 118617153 4552376 1615505..1616314 1 NC_008611.1 Catalyzes a key regulatory step in fatty acid biosynthesis; enoyl-(acyl carrier protein) reductase 1616314 inhA 4552376 inhA Mycobacterium ulcerans Agy99 enoyl-(acyl carrier protein) reductase YP_905485.1 1615505 D 362242 CDS YP_905486.1 118617154 4552377 1616321..1617343 1 NC_008611.1 protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic; ferrochelatase 1617343 hemH 4552377 hemH Mycobacterium ulcerans Agy99 ferrochelatase YP_905486.1 1616321 D 362242 CDS YP_905487.1 118617155 4552378 complement(1617350..1618345) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 1618345 4552378 MUL_1494 Mycobacterium ulcerans Agy99 hypothetical protein YP_905487.1 1617350 R 362242 CDS YP_905488.1 118617156 4552379 1618312..1619646 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2606; transposase for IS2606 1619646 4552379 MUL_1495 Mycobacterium ulcerans Agy99 transposase for IS2606 YP_905488.1 1618312 D 362242 CDS YP_905489.1 118617157 4552380 1619804..1620238 1 NC_008611.1 membrane protein; function unknown. contains Cdd match to COG1585, COG1585, membrane protein implicated in regulation of membrane protease activity [posttranslational modification, protein turnover, chaperones / intracellular trafficking and secretion]; hypothetical protein 1620238 4552380 MUL_1496 Mycobacterium ulcerans Agy99 hypothetical protein YP_905489.1 1619804 D 362242 CDS YP_905490.1 118617158 4552382 1621425..1621769 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; hypothetical protein 1621769 4552382 MUL_1498 Mycobacterium ulcerans Agy99 hypothetical protein YP_905490.1 1621425 D 362242 CDS YP_905491.1 118617159 4552383 complement(1621766..1622200) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; hypothetical protein 1622200 4552383 MUL_1499 Mycobacterium ulcerans Agy99 hypothetical protein YP_905491.1 1621766 R 362242 CDS YP_905492.1 118617160 4552384 complement(1622266..1622880) 1 NC_008611.1 cytoplasmic protein; involved in transcriptional mechanism.; transcriptional regulator 1622880 4552384 MUL_1500 Mycobacterium ulcerans Agy99 transcriptional regulator YP_905492.1 1622266 R 362242 CDS YP_905493.1 118617161 4552385 1623755..1624498 1 NC_008611.1 cytoplasmic protein; contains N-terminal Cdd pfam00072, response_reg, response regulator receiver domain. this domain receives the signal from the sensor partner in bacterial two- component systems. it is usually found N-terminal to a DNA binding effector domain. C-terminal conatins Cdd pfam00486, trans_reg_C, transcriptional regulatory protein, C terminal.; two component regulator receiver domain-containing protein 1624498 4552385 MUL_1501 Mycobacterium ulcerans Agy99 two component regulator receiver domain-containing protein YP_905493.1 1623755 D 362242 CDS YP_905494.1 118617162 4552386 1624498..1626018 1 NC_008611.1 membrane protein; two component system response sensor kinase contains Cdd pfam02518, hATPase_C, histidine kinase-, DNA gyrase B-, and Hsp90-like ATPase; Cdd pfam00512, HisKA, His kinase a (phosphoacceptor) domain. dimerisation and phosphoacceptor domain of histidine kinases.; two component regulator - sensor kinase 1626018 4552386 MUL_1502 Mycobacterium ulcerans Agy99 two component regulator - sensor kinase YP_905494.1 1624498 D 362242 CDS YP_905495.1 118617163 4552387 complement(1626023..1626838) 1 NC_008611.1 membrane protein; hypothetical protein 1626838 4552387 MUL_1503 Mycobacterium ulcerans Agy99 hypothetical protein YP_905495.1 1626023 R 362242 CDS YP_905496.1 118617164 4552388 complement(1627062..1627841) 1 NC_008611.1 membrane protein; conserved membrane protein of unknown function. similar to proteins from many organisms containing Cdd COG0398; uncharacterized conserved protein [function unknown]; hypothetical protein 1627841 4552388 MUL_1504 Mycobacterium ulcerans Agy99 hypothetical protein YP_905496.1 1627062 R 362242 CDS YP_905497.1 118617165 4552389 1628029..1629906 1 NC_008611.1 membrane protein; involved in propionic acid fermentation. catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid- cycle intermediates [catalytic activity: (R)-2-methyl-3- oxopropanoyl-CoA = succinyl- CoA]; methylmalonyl-CoA mutase small subunit, MutA 1629906 mutA 4552389 mutA Mycobacterium ulcerans Agy99 methylmalonyl-CoA mutase small subunit, MutA YP_905497.1 1628029 D 362242 CDS YP_905498.1 118617166 4552390 1629912..1632173 1 NC_008611.1 MDM; functions in conversion of succinate to propionate; methylmalonyl-CoA mutase 1632173 mutB 4552390 mutB Mycobacterium ulcerans Agy99 methylmalonyl-CoA mutase YP_905498.1 1629912 D 362242 CDS YP_905499.1 118617167 4552391 1632262..1633251 1 NC_008611.1 functions in transport of arginine/ornithine; inner membrane ATPase that cleaves ATP and phosphorylates two periplasmic proteins that function as two distinct transport systems, the AO (arginine and ornithine) and LAO (lysine, arginine, and ornithine) periplasmic binding proteins; arginine/ornithine transport system ATPase 1633251 4552391 MUL_1507 Mycobacterium ulcerans Agy99 arginine/ornithine transport system ATPase YP_905499.1 1632262 D 362242 CDS YP_905500.1 118617168 4552393 complement(1634621..1634833) 1 NC_008611.1 cytoplasmic protein; function unknown. contains Cdd pfam07311, DUF1458, protein of unknown function (DUF1458) this family consists of several hypothetical bacterial proteins as well as one archaeal sequence. members of this family are typically of around 70 residues in length. the function of this family is unknown.; hypothetical protein 1634833 4552393 MUL_1509 Mycobacterium ulcerans Agy99 hypothetical protein YP_905500.1 1634621 R 362242 CDS YP_905501.1 118617169 4552360 complement(1634961..1635740) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 1635740 4552360 MUL_1510 Mycobacterium ulcerans Agy99 hypothetical protein YP_905501.1 1634961 R 362242 CDS YP_905502.1 118617170 4552361 1635989..1637245 1 NC_008611.1 cytoplasmic protein; possibly involved in polysaccharide biosynthesis [catalytic activity: UDP-glucose + 2 NAD+ + H2O = UDP- glucuronate + 2 NADH] belongs to UDP-glucose/GDP-mannose dehydrogenase family; UDP-glucose 6-dehydrogenase 1637245 4552361 MUL_1511 Mycobacterium ulcerans Agy99 UDP-glucose 6-dehydrogenase YP_905502.1 1635989 D 362242 CDS YP_905503.1 118617171 4552362 1637242..1638261 1 NC_008611.1 cytoplasmic protein; involved in galactofuranosyl biosynthesis: converts UDO-GlcP to UDP-GalP [catalytic activity: UDP- glucopyranose = UDP-galactopyranose]; UDP-glucose 4-epimerase 1638261 4552362 MUL_1512 Mycobacterium ulcerans Agy99 UDP-glucose 4-epimerase YP_905503.1 1637242 D 362242 CDS YP_905504.1 118617172 4552366 1642065..1642769 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; N-term transposase for IS2404 1642769 4552366 MUL_1518 Mycobacterium ulcerans Agy99 N-term transposase for IS2404 YP_905504.1 1642065 D 362242 CDS YP_905505.1 118617173 4552367 1642800..1643111 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; C-term transposase for IS2404 1643111 4552367 MUL_1519 Mycobacterium ulcerans Agy99 C-term transposase for IS2404 YP_905505.1 1642800 D 362242 CDS YP_905506.1 118617174 4552368 1643319..1644650 1 NC_008611.1 cytoplasmic protein; required for the transposition of the insertion element IS2606.; transposase for IS2606 1644650 4552368 MUL_1520 Mycobacterium ulcerans Agy99 transposase for IS2606 YP_905506.1 1643319 D 362242 CDS YP_905507.1 118617175 4552370 1645717..1645884 1 NC_008611.1 cytoplasmic protein; hypothetical protein 1645884 4552370 MUL_5113 Mycobacterium ulcerans Agy99 hypothetical protein YP_905507.1 1645717 D 362242 CDS YP_905508.1 118617176 4552371 1646073..1646306 1 NC_008611.1 cytoplasmic protein; hypothetical protein 1646306 4552371 MUL_1522 Mycobacterium ulcerans Agy99 hypothetical protein YP_905508.1 1646073 D 362242 CDS YP_905509.1 118617177 4552372 1646564..1647331 1 NC_008611.1 membrane protein; possibly involved in cell wall arabinogalactan linker formation: uses dTDP-L-rhamnose as substrate to insert the rhamnosyl residue into the cell wall; rhamnosyl transferase WbbL2 1647331 wbbL2 4552372 wbbL2 Mycobacterium ulcerans Agy99 rhamnosyl transferase WbbL2 YP_905509.1 1646564 D 362242 CDS YP_905510.1 118617178 4552374 1648150..1648899 1 NC_008611.1 cytoplasmic protein; function unknown.contains Cdd pfam00535, glycos_transf_2, glycosyl transferase. diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.; glycosyl transferase 1648899 4552374 MUL_1526 Mycobacterium ulcerans Agy99 glycosyl transferase YP_905510.1 1648150 D 362242 CDS YP_905511.1 118617179 4552375 complement(1649017..1649751) 1 NC_008611.1 membrane protein; hypothetical protein 1649751 4552375 MUL_1527 Mycobacterium ulcerans Agy99 hypothetical protein YP_905511.1 1649017 R 362242 CDS YP_905512.1 118617180 4552340 1650047..1651093 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 1651093 4552340 MUL_1528 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_905512.1 1650047 D 362242 CDS YP_905513.1 118617181 4552341 complement(1651094..1652236) 1 NC_008611.1 membrane protein; function unknown. contains Cdd COG1819, glycosyl transferases, related to UDP-glucuronosyltransferase [carbohydrate transport and metabolism / signal transduction mechanisms]; UDP-glycosyltransferase 1652236 4552341 MUL_1529 Mycobacterium ulcerans Agy99 UDP-glycosyltransferase YP_905513.1 1651094 R 362242 CDS YP_905514.1 118617182 4552342 complement(1652337..1653710) 1 NC_008611.1 membrane protein; function unknown. similarity to Cdd pfam03007. uncharacterised protein family (UPF0089) this family of uncharacterised proteins is greatly expanded in mycobacterium tuberculosis. the most conserved region of the proteins contains conserved histidine and aspartate residues suggesting a possible metal binding site suggestive of a protease activity.; hypothetical protein 1653710 4552342 MUL_1530 Mycobacterium ulcerans Agy99 hypothetical protein YP_905514.1 1652337 R 362242 CDS YP_905515.1 118617183 4552343 complement(1653725..1655233) 1 NC_008611.1 cytoplasmic protein; function unknown. thought to be involved in lipid metabolism.; polyketide synthase associated protein PapA3 1655233 papA3 4552343 papA3 Mycobacterium ulcerans Agy99 polyketide synthase associated protein PapA3 YP_905515.1 1653725 R 362242 CDS YP_905516.1 118617184 4552344 1655932..1659132 1 NC_008611.1 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 2 subfamily; some organisms carry two different copies of this enzyme; in some organisms, the type 2 subfamily is associated with resistance to the antibiotic pseudomonic acid (mupirocin); isoleucyl-tRNA synthetase 1659132 ileS 4552344 ileS Mycobacterium ulcerans Agy99 isoleucyl-tRNA synthetase YP_905516.1 1655932 D 362242 CDS YP_905517.1 118617185 4552346 complement(1660244..1660816) 1 NC_008611.1 cytoplasmic protein; function unknown. partial Cdd COG0030, KsgA, dimethyladenosine transferase (rRNA methylation) [translation, ribosomal structure and biogenesis]; hypothetical protein 1660816 4552346 MUL_1534 Mycobacterium ulcerans Agy99 hypothetical protein YP_905517.1 1660244 R 362242 CDS YP_905518.1 118617186 4552347 1660874..1662295 1 NC_008611.1 involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function; DNA polymerase IV 1662295 dinP_1 4552347 dinP_1 Mycobacterium ulcerans Agy99 DNA polymerase IV YP_905518.1 1660874 D 362242 CDS YP_905519.1 118617187 4552348 complement(1662260..1663249) 1 NC_008611.1 cytoplasmic protein; conversion of asparagine to aspartate; L-aparaginase AnsA 1663249 ansA 4552348 ansA Mycobacterium ulcerans Agy99 L-aparaginase AnsA YP_905519.1 1662260 R 362242 CDS YP_905520.1 118617188 4552349 1662953..1663882 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; this protein specifically catalyzes the removal of signal peptides from prolipoproteins [catalytic activity : cleavage of N-terminal leader sequences from membrane prolipoproteins; lipoprotein signal peptidase LspA 1663882 lspA 4552349 lspA Mycobacterium ulcerans Agy99 lipoprotein signal peptidase LspA YP_905520.1 1662953 D 362242 CDS YP_905521.1 118617189 4552350 1663879..1664916 1 NC_008611.1 membrane protein; pseudouridine synthase (pseudouridylate synthase) (uracil hydrolyase)[catalytic activity] uracil + D-ribose 5-phosphate = pseudouridine 5'-phosphate + H(2)O.; RluA family pseudouridine synthase 1664916 4552350 MUL_1538 Mycobacterium ulcerans Agy99 RluA family pseudouridine synthase YP_905521.1 1663879 D 362242 CDS YP_905522.1 118617190 4552351 complement(1664817..1665524) 1 NC_008611.1 cytoplasmic protein; function unknown. contains partial Cdd COG2226, UbiE, methylase involved in ubiquinone/menaquinone biosynthesis; hypothetical protein 1665524 4552351 MUL_1539 Mycobacterium ulcerans Agy99 hypothetical protein YP_905522.1 1664817 R 362242 CDS YP_905523.1 118617191 4552352 complement(1665883..1666518) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; function unknown.; lipoprotein, LprL 1666518 lprL 4552352 lprL Mycobacterium ulcerans Agy99 lipoprotein, LprL YP_905523.1 1665883 R 362242 CDS YP_905524.1 118617192 4552353 complement(1666602..1667012) 1 NC_008611.1 cytoplasmic protein; oxygen transport. this family of HemE binding proteins are found mainly in bacteria.; globin family protein 1667012 glbN 4552353 glbN Mycobacterium ulcerans Agy99 globin family protein YP_905524.1 1666602 R 362242 CDS YP_905525.1 118617193 4552355 1668263..1669066 1 NC_008611.1 Detected in the cytoplasmic fraction; membrane protein; possibly involvement in lipid metabolism; ketoacyl reductase 1669066 4552355 MUL_1543 Mycobacterium ulcerans Agy99 ketoacyl reductase YP_905525.1 1668263 D 362242 CDS YP_905526.1 118617194 4552356 1669186..1669617 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS. Also detected in the membrane fraction by proteomics (2D-LC-MS/MS); cytoplasmic protein; hypothetical protein 1669617 4552356 MUL_1544 Mycobacterium ulcerans Agy99 hypothetical protein YP_905526.1 1669186 D 362242 CDS YP_905527.1 118617195 4552357 1669684..1673226 1 NC_008611.1 catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase; DNA polymerase III subunit alpha 1673226 dnaE 4552357 dnaE Mycobacterium ulcerans Agy99 DNA polymerase III subunit alpha YP_905527.1 1669684 D 362242 CDS YP_905528.1 118617196 4552358 1673353..1675179 1 NC_008611.1 membrane protein; probably involved in lipid degradation; fatty-acid-CoA ligase, FadD11 1675179 fadD11 4552358 fadD11 Mycobacterium ulcerans Agy99 fatty-acid-CoA ligase, FadD11 YP_905528.1 1673353 D 362242 CDS YP_905529.1 118617197 4552359 1675194..1677068 1 NC_008611.1 PlsB; catalyzes the formation of 1-acyl-sn-glycerol 3-phosphate by transfering the acyl moiety from acyl-CoA; glycerol-3-phosphate acyltransferase 1677068 plsB1 4552359 plsB1 Mycobacterium ulcerans Agy99 glycerol-3-phosphate acyltransferase YP_905529.1 1675194 D 362242 CDS YP_905530.1 118617198 4552321 complement(1677076..1677306) 1 NC_008611.1 secreted protein; function unknown.; hypothetical protein 1677306 4552321 MUL_1548 Mycobacterium ulcerans Agy99 hypothetical protein YP_905530.1 1677076 R 362242 CDS YP_905531.1 118617199 4552322 1677348..1677845 1 NC_008611.1 Detected in the cytoplasmic and secreted fractions by 2D-LC-MS/MS.; secreted protein; function unknown. contains Cdd pfam04075, domain of unknown function (DUF385) family of mycobacterium tuberculosis proteins.; hypothetical protein 1677845 4552322 MUL_1549 Mycobacterium ulcerans Agy99 hypothetical protein YP_905531.1 1677348 D 362242 CDS YP_905532.1 118617200 4552323 1677889..1679169 1 NC_008611.1 catalyzes the formation of 2-oxobutanoate from L-threonine; biosynthetic; threonine dehydratase 1679169 ilvA 4552323 ilvA Mycobacterium ulcerans Agy99 threonine dehydratase YP_905532.1 1677889 D 362242 CDS YP_905533.1 118617201 4552324 complement(1679197..1679733) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 1679733 4552324 MUL_1551 Mycobacterium ulcerans Agy99 hypothetical protein YP_905533.1 1679197 R 362242 CDS YP_905534.1 118617202 4552325 1679775..1681100 1 NC_008611.1 cytoplasmic protein; involved in transcriptional mechanism.; GntR family transcriptional regulator 1681100 4552325 MUL_1552 Mycobacterium ulcerans Agy99 GntR family transcriptional regulator YP_905534.1 1679775 D 362242 CDS YP_905535.1 118617203 4552326 complement(1681113..1682876) 1 NC_008611.1 cytoplasmic protein; involved in trehalose biosynthesis (protective effect) mycobacteria can produce trehalose from glucose 6- phosphate and UDP-glucose (the OtsA-OtsB pathway) from glycogen-like alpha(1-->4)-linked glucose polymers (the TreY-TreZ pathway) and from maltose (the TreS pathway); maltooligosyltrehalose trehalohydrolase, TreZ 1682876 treZ 4552326 treZ Mycobacterium ulcerans Agy99 maltooligosyltrehalose trehalohydrolase, TreZ YP_905535.1 1681113 R 362242 CDS YP_905536.1 118617204 4552327 complement(1682873..1685170) 1 NC_008611.1 membrane protein; involved in trehalose biosynthesis (protective effect) mycobacteria can produce trehalose from glucose 6- phosphate and UDP-glucose (the OtsA-OtsB pathway) from glycogen-like alpha(1-->4)-linked glucose polymers (the TreY-TreZ pathway); maltooligosyltrehalose synthase TreY 1685170 treY 4552327 treY Mycobacterium ulcerans Agy99 maltooligosyltrehalose synthase TreY YP_905536.1 1682873 R 362242 CDS YP_905537.1 118617205 4552328 complement(1685174..1687351) 1 NC_008611.1 cytoplasmic protein; possibly involved in trehalose biosynthesis (protective effect) mycobacteria can produce trehalose from glucose 6-phosphate and UDP-glucose (the OtsA-OtsB pathway) from glycogen-like alpha(1-->4)-linked glucose polymers (the TreY-TreZ pathway); maltooligosyltrehalose synthase TreX 1687351 treX 4552328 treX Mycobacterium ulcerans Agy99 maltooligosyltrehalose synthase TreX YP_905537.1 1685174 R 362242 CDS YP_905538.1 118617206 4552329 complement(1687451..1689616) 1 NC_008611.1 membrane protein; hypothetical protein 1689616 4552329 MUL_1556 Mycobacterium ulcerans Agy99 hypothetical protein YP_905538.1 1687451 R 362242 CDS YP_905539.1 118617207 4552330 complement(1689724..1690503) 1 NC_008611.1 Detected in the secreted protein fraction by 2D-LC- MS/MS.; secreted protein; possible inv protein, probably exported as has QQAPV repeats at c-terminus.; inv protein 1690503 4552330 MUL_1557 Mycobacterium ulcerans Agy99 inv protein YP_905539.1 1689724 R 362242 CDS YP_905540.1 118617208 4552331 complement(1690849..1691301) 1 NC_008611.1 membrane protein; hypothetical protein 1691301 4552331 MUL_1558 Mycobacterium ulcerans Agy99 hypothetical protein YP_905540.1 1690849 R 362242 CDS YP_905541.1 118617209 4552332 1691386..1692699 1 NC_008611.1 catalyzes the formation of S-adenosyl-4-methylthionine-2-oxobutanoate and 7,8-diaminononanoate from S-adenosyl-L-methionine and 8-amino-7-oxononanoate; adenosylmethionine--8-amino-7-oxononanoate transaminase 1692699 bioA 4552332 bioA Mycobacterium ulcerans Agy99 adenosylmethionine--8-amino-7-oxononanoate transaminase YP_905541.1 1691386 D 362242 CDS YP_905542.1 118617210 4552333 1692706..1693875 1 NC_008611.1 catalyzes the formation of 8-amino-7-oxononanoate from 6-carboxyhexanoyl-CoA and L-alanine; 8-amino-7-oxononanoate synthase 1693875 bioF1 4552333 bioF1 Mycobacterium ulcerans Agy99 8-amino-7-oxononanoate synthase YP_905542.1 1692706 D 362242 CDS YP_905543.1 118617211 4552334 1693872..1694552 1 NC_008611.1 DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium; dithiobiotin synthetase 1694552 bioD 4552334 bioD Mycobacterium ulcerans Agy99 dithiobiotin synthetase YP_905543.1 1693872 D 362242 CDS YP_905544.1 118617212 4552335 1694554..1695063 1 NC_008611.1 membrane protein; hypothetical protein 1695063 4552335 MUL_1562 Mycobacterium ulcerans Agy99 hypothetical protein YP_905544.1 1694554 D 362242 CDS YP_905545.1 118617213 4552336 1695213..1696265 1 NC_008611.1 catalyzes the formation of biotin from dethiobiotin and sulfur 2 S-adenosyl-L-methionine; biotin synthase 1696265 bioB 4552336 bioB Mycobacterium ulcerans Agy99 biotin synthase YP_905545.1 1695213 D 362242 CDS YP_905546.1 118617214 4552337 1696281..1696508 1 NC_008611.1 cytoplasmic protein; hypothetical protein 1696508 4552337 MUL_1564 Mycobacterium ulcerans Agy99 hypothetical protein YP_905546.1 1696281 D 362242 CDS YP_905547.1 118617215 4552338 1696520..1697203 1 NC_008611.1 membrane protein; hypothetical protein 1697203 4552338 MUL_1565 Mycobacterium ulcerans Agy99 hypothetical protein YP_905547.1 1696520 D 362242 CDS YP_905548.1 118617216 4552339 complement(1697249..1698589) 1 NC_008611.1 membrane protein; hypothetical protein 1698589 4552339 MUL_1566 Mycobacterium ulcerans Agy99 hypothetical protein YP_905548.1 1697249 R 362242 CDS YP_905549.1 118617217 4552303 complement(1698946..1699653) 1 NC_008611.1 cytoplasmic protein; function unknown, domain identity to ADP-ribose pyrophosphatases, possible role in nucleotide transport and metabolism.; hypothetical protein 1699653 4552303 MUL_1567 Mycobacterium ulcerans Agy99 hypothetical protein YP_905549.1 1698946 R 362242 CDS YP_905550.1 118617218 4552304 1699701..1700759 1 NC_008611.1 3 different subfamilies; catalyzes the formation of quinolinate from iminoaspartate and dihydroxyacetone phosphate; quinolinate synthetase 1700759 nadA 4552304 nadA Mycobacterium ulcerans Agy99 quinolinate synthetase YP_905550.1 1699701 D 362242 CDS YP_905551.1 118617219 4552305 1700756..1702330 1 NC_008611.1 catalyzes the formation of oxaloacetate from L-aspartate; L-aspartate oxidase 1702330 nadB 4552305 nadB Mycobacterium ulcerans Agy99 L-aspartate oxidase YP_905551.1 1700756 D 362242 CDS YP_905552.1 118617220 4552306 1702330..1703187 1 NC_008611.1 catalyzes the formation of pyridine-2,3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate from nictinate D-ribonucleotide; nicotinate-nucleotide pyrophosphorylase 1703187 nadC 4552306 nadC Mycobacterium ulcerans Agy99 nicotinate-nucleotide pyrophosphorylase YP_905552.1 1702330 D 362242 CDS YP_905553.1 118617221 4552307 complement(1703249..1703659) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 1703659 4552307 MUL_1571 Mycobacterium ulcerans Agy99 hypothetical protein YP_905553.1 1703249 R 362242 CDS YP_905554.1 118617222 4552308 1703744..1705087 1 NC_008611.1 catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer; histidinol dehydrogenase 1705087 hisD 4552308 hisD Mycobacterium ulcerans Agy99 histidinol dehydrogenase YP_905554.1 1703744 D 362242 CDS YP_905555.1 118617223 4552309 1705084..1706232 1 NC_008611.1 catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis; histidinol-phosphate aminotransferase 1706232 hisC1 4552309 hisC1 Mycobacterium ulcerans Agy99 histidinol-phosphate aminotransferase YP_905555.1 1705084 D 362242 CDS YP_905556.1 118617224 4552310 1706229..1706861 1 NC_008611.1 catalyzes the dehydration of D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate to 3-(imidazol-4-yl)-2-oxopropyl phosphate in histidine biosynthesis; imidazoleglycerol-phosphate dehydratase 1706861 hisB 4552310 hisB Mycobacterium ulcerans Agy99 imidazoleglycerol-phosphate dehydratase YP_905556.1 1706229 D 362242 CDS YP_905557.1 118617225 4552311 1706885..1707490 1 NC_008611.1 with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide; imidazole glycerol phosphate synthase subunit HisH 1707490 hisH 4552311 hisH Mycobacterium ulcerans Agy99 imidazole glycerol phosphate synthase subunit HisH YP_905557.1 1706885 D 362242 CDS YP_905558.1 118617226 4552312 1707502..1708236 1 NC_008611.1 catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide and the formation of 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate from N-(5-phospho-beta-D-ribosyl)anthranilate; involved in histidine and tryptophan biosynthesis; phosphoribosyl isomerase A 1708236 hisA 4552312 hisA Mycobacterium ulcerans Agy99 phosphoribosyl isomerase A YP_905558.1 1707502 D 362242 CDS YP_905559.1 118617227 4552313 1708243..1709055 1 NC_008611.1 cytoplasmic protein; involved in inositol phosphate metabolism. it is responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides. key enzyme of the phosphatidyl inositol signaling pathway [catalytic activity: inositol 1(or 4)-monophosphate + H(2)O = inositol + orthophosphate]; inositol-monophosphatase ImpA 1709055 impA 4552313 impA Mycobacterium ulcerans Agy99 inositol-monophosphatase ImpA YP_905559.1 1708243 D 362242 CDS YP_905560.1 118617228 4552314 1709057..1709842 1 NC_008611.1 catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase; imidazole glycerol phosphate synthase subunit HisF 1709842 hisF 4552314 hisF Mycobacterium ulcerans Agy99 imidazole glycerol phosphate synthase subunit HisF YP_905560.1 1709057 D 362242 CDS YP_905561.1 118617229 4552315 1709839..1710174 1 NC_008611.1 PR-AMP cyclohydrolase; functions in histidine biosynthesis from PRPP; converts 1-(5-phosphoribosyl)-AMP to 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxyamide during the histidine biosynthesis pathway; binds zinc and magnesium; forms homodimers; phosphoribosyl-AMP cyclohydrolase 1710174 hisI 4552315 hisI Mycobacterium ulcerans Agy99 phosphoribosyl-AMP cyclohydrolase YP_905561.1 1709839 D 362242 CDS YP_905562.1 118617230 4552316 complement(1710297..1711388) 1 NC_008611.1 cytoplasmic protein; function unknown.; deacylase 1711388 4552316 MUL_1580 Mycobacterium ulcerans Agy99 deacylase YP_905562.1 1710297 R 362242 CDS YP_905563.1 118617231 4552318 1711705..1713039 1 NC_008611.1 cytoplasmic protein; required for the transposition of the insertion element IS2606.; transposase for IS2606 1713039 4552318 MUL_1582 Mycobacterium ulcerans Agy99 transposase for IS2606 YP_905563.1 1711705 D 362242 CDS YP_905564.1 118617232 4552320 1713718..1714764 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 1714764 4552320 MUL_1584 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_905564.1 1713718 D 362242 CDS YP_905565.1 118617233 4552111 complement(1721808..1722266) 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; peroxide detoxification; peroxidoxin BcpB 1722266 bcpB 4552111 bcpB Mycobacterium ulcerans Agy99 peroxidoxin BcpB YP_905565.1 1721808 R 362242 CDS YP_905566.1 118617234 4552112 1722317..1723855 1 NC_008611.1 with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine; anthranilate synthase component I 1723855 trpE 4552112 trpE Mycobacterium ulcerans Agy99 anthranilate synthase component I YP_905566.1 1722317 D 362242 CDS YP_905567.1 118617235 4552113 1723848..1724543 1 NC_008611.1 membrane protein; hypothetical protein 1724543 4552113 MUL_1590 Mycobacterium ulcerans Agy99 hypothetical protein YP_905567.1 1723848 D 362242 CDS YP_905568.1 118617236 4552114 1724633..1725451 1 NC_008611.1 involved in tryptophan biosynthesis; amino acid biosynthesis; converts 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate to C(1)-(3-indolyl)-glycerol 3-phosphate and carbon dioxide and water; indole-3-glycerol-phosphate synthase 1725451 trpC 4552114 trpC Mycobacterium ulcerans Agy99 indole-3-glycerol-phosphate synthase YP_905568.1 1724633 D 362242 CDS YP_905569.1 118617237 4552115 1725487..1726764 1 NC_008611.1 catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate; tryptophan synthase subunit beta 1726764 trpB 4552115 trpB Mycobacterium ulcerans Agy99 tryptophan synthase subunit beta YP_905569.1 1725487 D 362242 CDS YP_905570.1 118617238 4552116 1726767..1727576 1 NC_008611.1 catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis; tryptophan synthase subunit alpha 1727576 trpA 4552116 trpA Mycobacterium ulcerans Agy99 tryptophan synthase subunit alpha YP_905570.1 1726767 D 362242 CDS YP_905571.1 118617239 4552118 1729539..1729931 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; hypothetical protein 1729931 4552118 MUL_1595 Mycobacterium ulcerans Agy99 hypothetical protein YP_905571.1 1729539 D 362242 CDS YP_905572.1 118617240 4552119 1729921..1730364 1 NC_008611.1 membrane protein; hypothetical protein 1730364 4552119 MUL_1596 Mycobacterium ulcerans Agy99 hypothetical protein YP_905572.1 1729921 D 362242 CDS YP_905573.1 118617241 4552120 complement(1730386..1731054) 1 NC_008611.1 secreted protein; hydrolysis of cutin.; cutinase Cut1 1731054 cut1 4552120 cut1 Mycobacterium ulcerans Agy99 cutinase Cut1 YP_905573.1 1730386 R 362242 CDS YP_905574.1 118617242 4552121 1731548..1732966 1 NC_008611.1 catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate kinase 1732966 pykA 4552121 pykA Mycobacterium ulcerans Agy99 pyruvate kinase YP_905574.1 1731548 D 362242 CDS YP_905575.1 118617243 4552122 1733090..1733971 1 NC_008611.1 cytoplasmic protein; involved in fatty acid metabolism.; acyl-CoA thioesterase II TesB1 1733971 tesB1 4552122 tesB1 Mycobacterium ulcerans Agy99 acyl-CoA thioesterase II TesB1 YP_905575.1 1733090 D 362242 CDS YP_905576.1 118617244 4552123 1734103..1735503 1 NC_008611.1 membrane protein; hypothetical protein 1735503 4552123 MUL_1600 Mycobacterium ulcerans Agy99 hypothetical protein YP_905576.1 1734103 D 362242 CDS YP_905577.1 118617245 4552124 complement(1735465..1737120) 1 NC_008611.1 secreted protein; involved in active transport across the membrane of component linked with the assembly of cytochrome: involved in cytochrome biogenesis (aerobic respiration) responsible for energy coupling to the transport system and for the translocation of the substrate across the membrane.; component linked with the assembly of cytochrome transport transmembrane ATP-binding protein ABC transporter CydC 1737120 cydC 4552124 cydC Mycobacterium ulcerans Agy99 component linked with the assembly of cytochrome transport transmembrane ATP-binding protein ABC transporter CydC YP_905577.1 1735465 R 362242 CDS YP_905578.1 118617246 4552125 complement(1737146..1738744) 1 NC_008611.1 secreted protein; involved in active transport across the membrane of component linked with the assembly of cytochrome: involved in cytochrome biogenesis (aerobic respiration) responsible for energy coupling to the transport system and for the translocation of the substrate across the membrane.; component linked with the assembly of cytochrome transport transmembrane ATP-binding protein ABC transporter CydD 1738744 cydD 4552125 cydD Mycobacterium ulcerans Agy99 component linked with the assembly of cytochrome transport transmembrane ATP-binding protein ABC transporter CydD YP_905578.1 1737146 R 362242 CDS YP_905579.1 118617247 4552126 complement(1738257..1739873) 1 NC_008611.1 membrane protein; involved in the respiratory chain (at the terminal step): aerobic respiration. cytochrome D terminal oxidase complex is the component of the aerobic respiratory chain that is supposed predominated when cells are grown at low aeration [catalytic activity: ubiquinol-8 + O(2) = ubiquinone-8 + H(2)O]; integral membrane cytochrome D ubiquinol oxidase (subunit II) CydB 1739873 cydB 4552126 cydB Mycobacterium ulcerans Agy99 integral membrane cytochrome D ubiquinol oxidase (subunit II) CydB YP_905579.1 1738257 R 362242 CDS YP_905580.1 118617248 4552091 complement(1741482..1742060) 1 NC_008611.1 membrane protein; hypothetical protein 1742060 4552091 MUL_1605 Mycobacterium ulcerans Agy99 hypothetical protein YP_905580.1 1741482 R 362242 CDS YP_905581.1 118617249 4552094 1743757..1744383 1 NC_008611.1 Also detected in the extracellular matrix and the membrane fractions by proteomics.; cytoplasmic protein; sensor part of a two component regulatory system; two-component system transcriptional regulator 1744383 4552094 MUL_1608 Mycobacterium ulcerans Agy99 two-component system transcriptional regulator YP_905581.1 1743757 D 362242 CDS YP_905582.1 118617250 4552096 complement(1745631..1746071) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 1746071 4552096 MUL_1610 Mycobacterium ulcerans Agy99 hypothetical protein YP_905582.1 1745631 R 362242 CDS YP_905583.1 118617251 4552097 1746175..1748874 1 NC_008611.1 has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair; DNA polymerase I 1748874 polA 4552097 polA Mycobacterium ulcerans Agy99 DNA polymerase I YP_905583.1 1746175 D 362242 CDS YP_905584.1 118617252 4552098 1749255..1750700 1 NC_008611.1 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins; 30S ribosomal protein S1 1750700 rpsA 4552098 rpsA Mycobacterium ulcerans Agy99 30S ribosomal protein S1 YP_905584.1 1749255 D 362242 CDS YP_905585.1 118617253 4552099 1750713..1751936 1 NC_008611.1 catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis; in Mycobacterium tuberculosis the C-terminal UPF0157 domain appears to be necessary for proper folding of the N-terminal domain; dephospho-CoA kinase/protein folding accessory domain-containing protein 1751936 coaE 4552099 coaE Mycobacterium ulcerans Agy99 dephospho-CoA kinase/protein folding accessory domain-containing protein YP_905585.1 1750713 D 362242 CDS YP_905586.1 118617254 4552100 complement(1752054..1752605) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 1752605 4552100 MUL_1614 Mycobacterium ulcerans Agy99 hypothetical protein YP_905586.1 1752054 R 362242 CDS YP_905587.1 118617255 4552101 complement(1752651..1753091) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 1753091 4552101 MUL_1615 Mycobacterium ulcerans Agy99 hypothetical protein YP_905587.1 1752651 R 362242 CDS YP_905588.1 118617256 4552102 1753352..1755457 1 NC_008611.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion; excinuclease ABC subunit B 1755457 uvrB 4552102 uvrB Mycobacterium ulcerans Agy99 excinuclease ABC subunit B YP_905588.1 1753352 D 362242 CDS YP_905589.1 118617257 4552103 1755494..1756906 1 NC_008611.1 membrane protein; thought to be involved in transport of drug across the membrane (export) drug resistance by an export mechanism (conferes resistance to toxic compounds by removing them for the cells); drug efflux membrane protein 1756906 4552103 MUL_1617 Mycobacterium ulcerans Agy99 drug efflux membrane protein YP_905589.1 1755494 D 362242 CDS YP_905590.1 118617258 4552104 complement(1756895..1758463) 1 NC_008611.1 membrane protein; transmembrane protein 1758463 4552104 MUL_1618 Mycobacterium ulcerans Agy99 transmembrane protein YP_905590.1 1756895 R 362242 CDS YP_905591.1 118617259 4552105 1758785..1759225 1 NC_008611.1 Also detected in the extracellular matrix by proteomics.; cytoplasmic protein; function unknown, domain identity to universal stress protein family and to iron-regulated conserved hypothetical protein TB15.3 from M. tuberculosis H37Rv.; iron-regulated protein 1759225 4552105 MUL_1619 Mycobacterium ulcerans Agy99 iron-regulated protein YP_905591.1 1758785 D 362242 CDS YP_905592.1 118617260 4552106 1759594..1759986 1 NC_008611.1 Also detected in the extracellular matrix by proteomics.; cytoplasmic protein; hypothetical protein 1759986 4552106 MUL_1620 Mycobacterium ulcerans Agy99 hypothetical protein YP_905592.1 1759594 D 362242 CDS YP_905593.1 118617261 4552107 complement(1760106..1760783) 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; hypothetical protein 1760783 4552107 MUL_1621 Mycobacterium ulcerans Agy99 hypothetical protein YP_905593.1 1760106 R 362242 CDS YP_905594.1 118617262 4552071 1760979..1763894 1 NC_008611.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate; excinuclease ABC subunit A 1763894 uvrA 4552071 uvrA Mycobacterium ulcerans Agy99 excinuclease ABC subunit A YP_905594.1 1760979 D 362242 CDS YP_905595.1 118617263 4552073 complement(1765618..1765920) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 1765920 4552073 MUL_1624 Mycobacterium ulcerans Agy99 hypothetical protein YP_905595.1 1765618 R 362242 CDS YP_905596.1 118617264 4552074 complement(1766008..1767453) 1 NC_008611.1 membrane protein; hypothetical protein 1767453 4552074 MUL_1625 Mycobacterium ulcerans Agy99 hypothetical protein YP_905596.1 1766008 R 362242 CDS YP_905597.1 118617265 4552075 complement(1767497..1770790) 1 NC_008611.1 catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; lysyl-tRNA synthetase 1770790 lysS 4552075 lysS Mycobacterium ulcerans Agy99 lysyl-tRNA synthetase YP_905597.1 1767497 R 362242 CDS YP_905598.1 118617266 4552076 1771295..1771831 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.; initiation factor IF-3 InfC 1771831 infC 4552076 infC Mycobacterium ulcerans Agy99 initiation factor IF-3 InfC YP_905598.1 1771295 D 362242 CDS YP_905599.1 118617267 4552077 1771862..1772056 1 NC_008611.1 cytoplasmic protein; translation; 50S ribosomal protein L35 1772056 rpmI 4552077 rpmI Mycobacterium ulcerans Agy99 50S ribosomal protein L35 YP_905599.1 1771862 D 362242 CDS YP_905600.1 118617268 4552078 1772127..1772516 1 NC_008611.1 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit; 50S ribosomal protein L20 1772516 rplT 4552078 rplT Mycobacterium ulcerans Agy99 50S ribosomal protein L20 YP_905600.1 1772127 D 362242 CDS YP_905601.1 118617269 4552079 1772594..1773421 1 NC_008611.1 cytoplasmic protein; rRNA modification; 23S rRNA methyltransferase TsnR 1773421 tsnR 4552079 tsnR Mycobacterium ulcerans Agy99 23S rRNA methyltransferase TsnR YP_905601.1 1772594 D 362242 CDS YP_905602.1 118617270 4552080 complement(1773425..1774465) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 1774465 4552080 MUL_1631 Mycobacterium ulcerans Agy99 hypothetical protein YP_905602.1 1773425 R 362242 CDS YP_905603.1 118617271 4552081 1774819..1775760 1 NC_008611.1 membrane protein; PE family protein 1775760 4552081 MUL_1632 Mycobacterium ulcerans Agy99 PE family protein YP_905603.1 1774819 D 362242 CDS YP_905604.1 118617272 4552082 1775871..1776782 1 NC_008611.1 cytoplasmic protein; hypothetical protein 1776782 4552082 MUL_1633 Mycobacterium ulcerans Agy99 hypothetical protein YP_905604.1 1775871 D 362242 CDS YP_905605.1 118617273 4552083 1776792..1777574 1 NC_008611.1 membrane protein; transmembrane protein 1777574 4552083 MUL_1634 Mycobacterium ulcerans Agy99 transmembrane protein YP_905605.1 1776792 D 362242 CDS YP_905606.1 118617274 4552084 1777832..1778875 1 NC_008611.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily; phenylalanyl-tRNA synthetase subunit alpha 1778875 pheS 4552084 pheS Mycobacterium ulcerans Agy99 phenylalanyl-tRNA synthetase subunit alpha YP_905606.1 1777832 D 362242 CDS YP_905607.1 118617275 4552085 1778875..1781364 1 NC_008611.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily; phenylalanyl-tRNA synthetase subunit beta 1781364 pheT 4552085 pheT Mycobacterium ulcerans Agy99 phenylalanyl-tRNA synthetase subunit beta YP_905607.1 1778875 D 362242 CDS YP_905608.1 118617276 4552087 1782645..1783691 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 1783691 4552087 MUL_1638 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_905608.1 1782645 D 362242 CDS YP_905609.1 118617277 4552088 1785150..1786820 1 NC_008611.1 membrane protein; function unknown.; PE-PGRS family protein 1786820 4552088 MUL_1639 Mycobacterium ulcerans Agy99 PE-PGRS family protein YP_905609.1 1785150 D 362242 CDS YP_905610.1 118617278 4552089 1787077..1788921 1 NC_008611.1 membrane protein; function unknown.; PE-PGRS family protein 1788921 4552089 MUL_1640 Mycobacterium ulcerans Agy99 PE-PGRS family protein YP_905610.1 1787077 D 362242 CDS YP_905611.1 118617279 4552055 1790352..1791398 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 1791398 4552055 MUL_1642 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_905611.1 1790352 D 362242 CDS YP_905612.1 118617280 4552056 complement(1792173..1793507) 1 NC_008611.1 cytoplasmic protein; required for the transposition of the insertion element IS2606.; transposase for IS2606 1793507 4552056 MUL_1643 Mycobacterium ulcerans Agy99 transposase for IS2606 YP_905612.1 1792173 R 362242 CDS YP_905613.1 118617281 4552057 1795252..1796304 1 NC_008611.1 catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate; N-acetyl-gamma-glutamyl-phosphate reductase 1796304 argC 4552057 argC Mycobacterium ulcerans Agy99 N-acetyl-gamma-glutamyl-phosphate reductase YP_905613.1 1795252 D 362242 CDS YP_905614.1 118617282 4552058 1796377..1797591 1 NC_008611.1 bifunctional arginine biosynthesis protein ArgJ; functions at the 1st and 5th steps in arginine biosynthesis; involved in synthesis of acetylglutamate from glutamate and acetyl-CoA and ornithine by transacetylation between acetylornithine and glutmate; bifunctional ornithine acetyltransferase/N-acetylglutamate synthase protein 1797591 argJ 4552058 argJ Mycobacterium ulcerans Agy99 bifunctional ornithine acetyltransferase/N-acetylglutamate synthase protein YP_905614.1 1796377 D 362242 CDS YP_905615.1 118617283 4552059 1797588..1798469 1 NC_008611.1 catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate; acetylglutamate kinase 1798469 argB 4552059 argB Mycobacterium ulcerans Agy99 acetylglutamate kinase YP_905615.1 1797588 D 362242 CDS YP_905616.1 118617284 4552060 1798466..1799656 1 NC_008611.1 catalyzes the formation of N-acetyl-l-glutamate 5-semialdehyde from 2-oxoglutarate and N(2)-acetyl-L-ornithine; acetylornithine aminotransferase 1799656 argD 4552060 argD Mycobacterium ulcerans Agy99 acetylornithine aminotransferase YP_905616.1 1798466 D 362242 CDS YP_905617.1 118617285 4552061 1799653..1800579 1 NC_008611.1 catalyzes the formation of L-citrulline from carbamoyl phosphate and L-ornithine in arginine biosynthesis and degradation; ornithine carbamoyltransferase 1800579 argF 4552061 argF Mycobacterium ulcerans Agy99 ornithine carbamoyltransferase YP_905617.1 1799653 D 362242 CDS YP_905618.1 118617286 4552062 1800576..1801076 1 NC_008611.1 regulates arginine biosynthesis when complexed with arginine by binding at site that overlap the promotors of the arginine biosynthesis genes; arginine repressor 1801076 argR 4552062 argR Mycobacterium ulcerans Agy99 arginine repressor YP_905618.1 1800576 D 362242 CDS YP_905619.1 118617287 4552063 1801125..1802321 1 NC_008611.1 catalyzes the formation of 2-N(omega)-(L-arginino)succinate from L-citrulline and L-aspartate in arginine biosynthesis, AMP-forming; argininosuccinate synthase 1802321 argG 4552063 argG Mycobacterium ulcerans Agy99 argininosuccinate synthase YP_905619.1 1801125 D 362242 CDS YP_905620.1 118617288 4552064 1802416..1803828 1 NC_008611.1 catalyzes the formation of arginine from (N-L-arginino)succinate; argininosuccinate lyase 1803828 argH 4552064 argH Mycobacterium ulcerans Agy99 argininosuccinate lyase YP_905620.1 1802416 D 362242 CDS YP_905621.1 118617289 4552068 1817861..1820953 1 NC_008611.1 membrane protein; polyketide synthase Pks9 1820953 pks9 4552068 pks9 Mycobacterium ulcerans Agy99 polyketide synthase Pks9 YP_905621.1 1817861 D 362242 CDS YP_905622.1 118617290 4552069 1821108..1822169 1 NC_008611.1 membrane protein; possibly involved in the biosynthesis of secondary metabolites [catalytic activity: 3 malonyl-CoA + 4- coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2]; chalcone synthase, Pks11 1822169 pks11 4552069 pks11 Mycobacterium ulcerans Agy99 chalcone synthase, Pks11 YP_905622.1 1821108 D 362242 CDS YP_905623.1 118617291 4551930 complement(1823233..1825215) 1 NC_008611.1 cytoplasmic protein; thought to be involved in active transport of macrolide across the membrane (export) macrolide antibiotics resistance by an export mechanism. responsible for energy coupling to the transport system; ABC transporter, ATP-binding protein 1825215 4551930 MUL_1658 Mycobacterium ulcerans Agy99 ABC transporter, ATP-binding protein YP_905623.1 1823233 R 362242 CDS YP_905624.1 118617292 4551931 1826160..1827272 1 NC_008611.1 membrane protein; wide specificity for D-amino acids. also acts on glycine [catalytic activity: a D-amino acid + H2O + O2 = a 2-oxo acid + NH3 + H2O2]; D-amino acid oxidase Aao_1 1827272 aao_1 4551931 aao_1 Mycobacterium ulcerans Agy99 D-amino acid oxidase Aao_1 YP_905624.1 1826160 D 362242 CDS YP_905625.1 118617293 4551932 1827419..1830424 1 NC_008611.1 activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 1830424 4551932 MUL_1660 Mycobacterium ulcerans Agy99 acyl-CoA synthetase YP_905625.1 1827419 D 362242 CDS YP_905626.1 118617294 4551933 1830417..1830650 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; hypothetical protein 1830650 4551933 MUL_1661 Mycobacterium ulcerans Agy99 hypothetical protein YP_905626.1 1830417 D 362242 CDS YP_905627.1 118617295 4551934 1830751..1831197 1 NC_008611.1 cytoplasmic protein; role in amino acid transport and metabolism; lactoylglutathione lyase, GloA 1831197 gloA 4551934 gloA Mycobacterium ulcerans Agy99 lactoylglutathione lyase, GloA YP_905627.1 1830751 D 362242 CDS YP_905628.1 118617296 4551936 complement(1833833..1834432) 1 NC_008611.1 cytoplasmic protein; unknwon; hypothetical protein 1834432 4551936 MUL_1664 Mycobacterium ulcerans Agy99 hypothetical protein YP_905628.1 1833833 R 362242 CDS YP_905629.1 118617297 4551937 complement(1834434..1835114) 1 NC_008611.1 membrane protein; thought to be involved in active transport of undeterminated substrate (possibly drug) across the membrane. responsible for the translocation of the substrate across the membrane; antibiotic resistance ABC transporter, efflux protein 1835114 4551937 MUL_1665 Mycobacterium ulcerans Agy99 antibiotic resistance ABC transporter, efflux protein YP_905629.1 1834434 R 362242 CDS YP_905630.1 118617298 4551938 complement(1835186..1835953) 1 NC_008611.1 membrane protein; thought to be involved in active transport of undeterminated substrate (possibly drug) across the membrane. responsible for energy coupling to the transport system; antibiotic resistance ABC transporter, efflux system, ATP-binding protein 1835953 4551938 MUL_1666 Mycobacterium ulcerans Agy99 antibiotic resistance ABC transporter, efflux system, ATP-binding protein YP_905630.1 1835186 R 362242 CDS YP_905631.1 118617299 4551939 1836013..1836624 1 NC_008611.1 responsible for recognizing base lesions in the genome and initiating base excision DNA repair; 3-methyladenine DNA glycosylase 1836624 mpg 4551939 mpg Mycobacterium ulcerans Agy99 3-methyladenine DNA glycosylase YP_905631.1 1836013 D 362242 CDS YP_905632.1 118617300 4551940 1836636..1837928 1 NC_008611.1 catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr); tyrosyl-tRNA synthetase 1837928 tyrS 4551940 tyrS Mycobacterium ulcerans Agy99 tyrosyl-tRNA synthetase YP_905632.1 1836636 D 362242 CDS YP_905633.1 118617301 4551941 1838234..1838524 1 NC_008611.1 cytoplasmic protein; function unknown. no blast similarities.; hypothetical protein 1838524 4551941 MUL_1669 Mycobacterium ulcerans Agy99 hypothetical protein YP_905633.1 1838234 D 362242 CDS YP_905634.1 118617302 4551942 complement(1838767..1839084) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; C-term transposase for IS2404 1839084 4551942 MUL_1670 Mycobacterium ulcerans Agy99 C-term transposase for IS2404 YP_905634.1 1838767 R 362242 CDS YP_905635.1 118617303 4551943 complement(1839109..1839813) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; N-term transposase for IS2404 1839813 4551943 MUL_1671 Mycobacterium ulcerans Agy99 N-term transposase for IS2404 YP_905635.1 1839109 R 362242 CDS YP_905636.1 118617304 4551945 complement(1841822..1843768) 1 NC_008611.1 membrane protein; hypothetical protein 1843768 4551945 MUL_1674 Mycobacterium ulcerans Agy99 hypothetical protein YP_905636.1 1841822 R 362242 CDS YP_905637.1 118617305 4551947 complement(1845469..1846515) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase from IS2404 1846515 4551947 MUL_1676 Mycobacterium ulcerans Agy99 transposase from IS2404 YP_905637.1 1845469 R 362242 CDS YP_905638.1 118617306 4551911 complement(1847317..1848810) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 1848810 4551911 MUL_1677 Mycobacterium ulcerans Agy99 hypothetical protein YP_905638.1 1847317 R 362242 CDS YP_905639.1 118617307 4551913 1850626..1851015 1 NC_008611.1 membrane protein; lipoprotein, LprJ 1851015 lprJ 4551913 lprJ Mycobacterium ulcerans Agy99 lipoprotein, LprJ YP_905639.1 1850626 D 362242 CDS YP_905640.1 118617308 4551914 1851076..1851909 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; hypothetical protein 1851909 4551914 MUL_1680 Mycobacterium ulcerans Agy99 hypothetical protein YP_905640.1 1851076 D 362242 CDS YP_905641.1 118617309 4551915 1851912..1852922 1 NC_008611.1 cytoplasmic protein; function unknown; probably involved in cellular metabolism; phosphatase 1852922 4551915 MUL_1681 Mycobacterium ulcerans Agy99 phosphatase YP_905641.1 1851912 D 362242 CDS YP_905642.1 118617310 4551916 1852947..1853123 1 NC_008611.1 cytoplasmic protein; hypothetical protein 1853123 4551916 MUL_1682 Mycobacterium ulcerans Agy99 hypothetical protein YP_905642.1 1852947 D 362242 CDS YP_905643.1 118617311 4551917 1853131..1853976 1 NC_008611.1 cytoplasmic protein; has a contact-dependent haemolytic activity; possibly involved in virulence (pore formation); cytotoxin/hemolysin, TlyA 1853976 tlyA 4551917 tlyA Mycobacterium ulcerans Agy99 cytotoxin/hemolysin, TlyA YP_905643.1 1853131 D 362242 CDS YP_905644.1 118617312 4551918 1853973..1854896 1 NC_008611.1 catalyzes the phosphorylation of NAD to NADP; inorganic polyphosphate/ATP-NAD kinase 1854896 ppnK 4551918 ppnK Mycobacterium ulcerans Agy99 inorganic polyphosphate/ATP-NAD kinase YP_905644.1 1853973 D 362242 CDS YP_905645.1 118617313 4551919 1854909..1856654 1 NC_008611.1 cytoplasmic protein; involved in recombinational repair of damaged DNA.; DNA repair protein, RecN 1856654 recN 4551919 recN Mycobacterium ulcerans Agy99 DNA repair protein, RecN YP_905645.1 1854909 D 362242 CDS YP_905646.1 118617314 4551920 1856820..1858001 1 NC_008611.1 membrane protein; hypothetical protein 1858001 4551920 MUL_1686 Mycobacterium ulcerans Agy99 hypothetical protein YP_905646.1 1856820 D 362242 CDS YP_905647.1 118617315 4551921 1858023..1858976 1 NC_008611.1 secreted protein; hypothetical protein 1858976 4551921 MUL_1687 Mycobacterium ulcerans Agy99 hypothetical protein YP_905647.1 1858023 D 362242 CDS YP_905648.1 118617316 4551922 1859114..1860865 1 NC_008611.1 CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer; CTP synthetase 1860865 pyrG 4551922 pyrG Mycobacterium ulcerans Agy99 CTP synthetase YP_905648.1 1859114 D 362242 CDS YP_905649.1 118617317 4551923 1860858..1861481 1 NC_008611.1 cytoplasmic protein; NUDIX hydrolases catalyze the hydrolysis of a variety of nucleoside diphosphate derivatives; NUDIX hydrolase 1861481 4551923 MUL_1689 Mycobacterium ulcerans Agy99 NUDIX hydrolase YP_905649.1 1860858 D 362242 CDS YP_905650.1 118617318 4551924 1861478..1862419 1 NC_008611.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; XerD specifically exchanges the bottom strands; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerD 1862419 xerD 4551924 xerD Mycobacterium ulcerans Agy99 site-specific tyrosine recombinase XerD YP_905650.1 1861478 D 362242 CDS YP_905651.1 118617319 4551925 complement(1862426..1863019) 1 NC_008611.1 cytoplasmic protein; catalyzes the O-methylation [catalytic activity: S- adenosyl-L-methionine + catechol = S-adenosyl-L- homocysteine + guaiacol]; O-methyltransferase 1863019 4551925 MUL_1691 Mycobacterium ulcerans Agy99 O-methyltransferase YP_905651.1 1862426 R 362242 CDS YP_905652.1 118617320 4551926 1863338..1864561 1 NC_008611.1 membrane protein; this is a family of myo-inositol-1-phosphate synthases. inositol-1-phosphate catalyses the conversion of glucose-6- phosphate to inositol-1-phosphate, which is then dephosphorylated to inositol. inositol phosphates play an important role in signal transduction.; myo-inositol-1-phosphate synthase 1864561 4551926 MUL_1692 Mycobacterium ulcerans Agy99 myo-inositol-1-phosphate synthase YP_905652.1 1863338 D 362242 CDS YP_905653.1 118617321 4551927 1864558..1865421 1 NC_008611.1 membrane protein; membrane associated. contains Cdd matches to polyprenyltransferase domains.; transferase 1865421 4551927 MUL_1693 Mycobacterium ulcerans Agy99 transferase YP_905653.1 1864558 D 362242 CDS YP_905654.1 118617322 4551928 1865421..1866842 1 NC_008611.1 cytoplasmic protein; contains Cdd COG1082,sugar phosphate isomerases/epimerases [carbohydrate transport and metabolism; sugar phosphate isomerases/epimerases 1866842 4551928 MUL_1694 Mycobacterium ulcerans Agy99 sugar phosphate isomerases/epimerases YP_905654.1 1865421 D 362242 CDS YP_905655.1 118617323 4551929 1866839..1867690 1 NC_008611.1 cytoplasmic protein; contains Cdd COG1099, predicted metal-dependent hydrolases with the TIM-barrel FolD.; metal dependant hydrolase 1867690 4551929 MUL_1695 Mycobacterium ulcerans Agy99 metal dependant hydrolase YP_905655.1 1866839 D 362242 CDS YP_905656.1 118617324 4551878 1868798..1870177 1 NC_008611.1 membrane protein; function unknown.; hypothetical protein 1870177 4551878 MUL_1697 Mycobacterium ulcerans Agy99 hypothetical protein YP_905656.1 1868798 D 362242 CDS YP_905657.1 118617325 4551879 1870323..1871297 1 NC_008611.1 cytoplasmic protein; hypothetical protein 1871297 4551879 MUL_1698 Mycobacterium ulcerans Agy99 hypothetical protein YP_905657.1 1870323 D 362242 CDS YP_905658.1 118617326 4551880 complement(1871298..1872344) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 1872344 4551880 MUL_1699 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_905658.1 1871298 R 362242 CDS YP_905659.1 118617327 4551882 complement(1874423..1875601) 1 NC_008611.1 Detected in the membrane fraction by proteomics (2D- LC-MS/MS); membrane protein; PPE family protein 1875601 4551882 MUL_1701 Mycobacterium ulcerans Agy99 PPE family protein YP_905659.1 1874423 R 362242 CDS YP_905660.1 118617328 4551883 complement(1875833..1876963) 1 NC_008611.1 PPE23; membrane protein; PPE family protein 1876963 4551883 MUL_1702 Mycobacterium ulcerans Agy99 PPE family protein YP_905660.1 1875833 R 362242 CDS YP_905661.1 118617329 4551885 complement(1881575..1881799) 1 NC_008611.1 cytoplasmic protein; thought to be involved in the biogenesis of the hydroxyphenyloxazoline-containing siderophore mycobactins; protein MbtH_2 1881799 mbtH_2 4551885 mbtH_2 Mycobacterium ulcerans Agy99 protein MbtH_2 YP_905661.1 1881575 R 362242 CDS YP_905662.1 118617330 4551886 complement(1881796..1883049) 1 NC_008611.1 cytoplasmic protein; function unknown, but involved in lipid degradation.; acyl-CoA dehydrogenase 1883049 4551886 MUL_1705 Mycobacterium ulcerans Agy99 acyl-CoA dehydrogenase YP_905662.1 1881796 R 362242 CDS YP_905663.1 118617331 4551887 complement(1883056..1883310) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 1883310 4551887 MUL_1706 Mycobacterium ulcerans Agy99 hypothetical protein YP_905663.1 1883056 R 362242 CDS YP_905664.1 118617332 4551888 complement(1883463..1884509) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 1884509 4551888 MUL_1707 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_905664.1 1883463 R 362242 CDS YP_905665.1 118617333 4551889 complement(1884789..1886375) 1 NC_008611.1 catalyzes the formation of spermidine from putrescine and S-adenosylmethioninamine; spermidine synthase 1886375 speE 4551889 speE Mycobacterium ulcerans Agy99 spermidine synthase YP_905665.1 1884789 R 362242 CDS YP_905666.1 118617334 4551890 complement(1886372..1886842) 1 NC_008611.1 membrane protein; hypothetical protein 1886842 4551890 MUL_1709 Mycobacterium ulcerans Agy99 hypothetical protein YP_905666.1 1886372 R 362242 CDS YP_905667.1 118617335 4551891 complement(1886876..1887256) 1 NC_008611.1 membrane protein; function unknown, possible membrane protein; hypothetical protein 1887256 4551891 MUL_1710 Mycobacterium ulcerans Agy99 hypothetical protein YP_905667.1 1886876 R 362242 CDS YP_905668.1 118617336 4551892 1887559..1888605 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 1888605 4551892 MUL_1711 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_905668.1 1887559 D 362242 CDS YP_905669.1 118617337 4551893 complement(1888680..1889192) 1 NC_008611.1 membrane protein; hypothetical protein 1889192 4551893 MUL_1712 Mycobacterium ulcerans Agy99 hypothetical protein YP_905669.1 1888680 R 362242 CDS YP_905670.1 118617338 4551862 complement(1889202..1889810) 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; hypothetical protein 1889810 4551862 MUL_1713 Mycobacterium ulcerans Agy99 hypothetical protein YP_905670.1 1889202 R 362242 CDS YP_905671.1 118617339 4551863 1890025..1890579 1 NC_008611.1 endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity; Holliday junction resolvase 1890579 ruvC 4551863 ruvC Mycobacterium ulcerans Agy99 Holliday junction resolvase YP_905671.1 1890025 D 362242 CDS YP_905672.1 118617340 4551864 1890576..1891169 1 NC_008611.1 plays an essential role in ATP-dependent branch migration of the Holliday junction; Holliday junction DNA helicase RuvA 1891169 ruvA 4551864 ruvA Mycobacterium ulcerans Agy99 Holliday junction DNA helicase RuvA YP_905672.1 1890576 D 362242 CDS YP_905673.1 118617341 4551865 1891173..1892210 1 NC_008611.1 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration; Holliday junction DNA helicase RuvB 1892210 ruvB 4551865 ruvB Mycobacterium ulcerans Agy99 Holliday junction DNA helicase RuvB YP_905673.1 1891173 D 362242 CDS YP_905674.1 118617342 4551867 complement(1894101..1895549) 1 NC_008611.1 membrane protein; PE-PGRS family protein 1895549 4551867 MUL_1718 Mycobacterium ulcerans Agy99 PE-PGRS family protein YP_905674.1 1894101 R 362242 CDS YP_905675.1 118617343 4551868 1895741..1896130 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; function unknown, domain identity membrane protein Cdd COG3759; hypothetical protein 1896130 4551868 MUL_1719 Mycobacterium ulcerans Agy99 hypothetical protein YP_905675.1 1895741 D 362242 CDS YP_905676.1 118617344 4551869 1896220..1896912 1 NC_008611.1 secreted protein; hypothetical protein 1896912 4551869 MUL_1720 Mycobacterium ulcerans Agy99 hypothetical protein YP_905676.1 1896220 D 362242 CDS YP_905677.1 118617345 4551870 complement(1897225..1898610) 1 NC_008611.1 membrane protein; PE_PGRS family protein 1898610 4551870 MUL_1721 Mycobacterium ulcerans Agy99 PE_PGRS family protein YP_905677.1 1897225 R 362242 CDS YP_905678.1 118617346 4551871 complement(1898764..1902288) 1 NC_008611.1 cytoplasmic protein; function unknown, but involved in lipid degradation.; fatty-acid-CoA ligase FadD9 1902288 4551871 MUL_1722 Mycobacterium ulcerans Agy99 fatty-acid-CoA ligase FadD9 YP_905678.1 1898764 R 362242 CDS YP_905679.1 118617347 4551872 complement(1902469..1903809) 1 NC_008611.1 catalyzes the formation of succinate semialdehyde and glutamate from 4-aminobutanoate and 2-oxoglutarate; 4-aminobutyrate aminotransferase 1903809 gabT 4551872 gabT Mycobacterium ulcerans Agy99 4-aminobutyrate aminotransferase YP_905679.1 1902469 R 362242 CDS YP_905680.1 118617348 4551873 1904039..1904380 1 NC_008611.1 member of preprotein translocase; forms a heterotrimer with SecD and SecF; links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex; preprotein translocase subunit YajC 1904380 yajC 4551873 yajC Mycobacterium ulcerans Agy99 preprotein translocase subunit YajC YP_905680.1 1904039 D 362242 CDS YP_905681.1 118617349 4551874 1904493..1906340 1 NC_008611.1 part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; preprotein translocase subunit SecD 1906340 secD 4551874 secD Mycobacterium ulcerans Agy99 preprotein translocase subunit SecD YP_905681.1 1904493 D 362242 CDS YP_905682.1 118617350 4551875 1906345..1907685 1 NC_008611.1 forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF; preprotein translocase subunit SecF 1907685 secF 4551875 secF Mycobacterium ulcerans Agy99 preprotein translocase subunit SecF YP_905682.1 1906345 D 362242 CDS YP_905683.1 118617351 4551876 1907691..1909403 1 NC_008611.1 secreted protein; function unknown. possible COG0747, DdpA, ABC-type dipeptide transport system, periplasmic component [amino acid transport and metabolism]; ABC-type dipeptide transport system, periplasmic component 1909403 4551876 MUL_1727 Mycobacterium ulcerans Agy99 ABC-type dipeptide transport system, periplasmic component YP_905683.1 1907691 D 362242 CDS YP_905684.1 118617352 4551824 1909400..1909954 1 NC_008611.1 catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis; adenine phosphoribosyltransferase 1909954 apt 4551824 apt Mycobacterium ulcerans Agy99 adenine phosphoribosyltransferase YP_905684.1 1909400 D 362242 CDS YP_905685.1 118617353 4551825 1910022..1912394 1 NC_008611.1 Detected in the cytoplamic fraction by LCMSMS; cytoplasmic protein; involved in the metabolism of PPGPP (at the first step) in eubacteria PPGPP (guanosine 3'-diphosphate 5- 'diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. this enzyme catalyzes the formation of PPPGPP which is then hydrolysed to form PPGPP [catalytic activity: ATP + GTP = AMP + guanosine 3'- diphosphate 5-'triphosphate]; GTP pyrophosphokinase RelA 1912394 relA 4551825 relA Mycobacterium ulcerans Agy99 GTP pyrophosphokinase RelA YP_905685.1 1910022 D 362242 CDS YP_905686.1 118617354 4551826 complement(1912451..1913428) 1 NC_008611.1 Detected in the secreted and membrane fractions by proteomics.; membrane protein; Ppiases accelerate the folding of proteins [catalytic activity: cis-trans isomerization of proline imidic peptide bonds in oligopeptides]; peptidyl-prolyl cis-trans isomerase B PpiB 1913428 ppiB 4551826 ppiB Mycobacterium ulcerans Agy99 peptidyl-prolyl cis-trans isomerase B PpiB YP_905686.1 1912451 R 362242 CDS YP_905687.1 118617355 4551827 1913479..1914153 1 NC_008611.1 cytoplasmic protein; involved in glyoxal pathway. thioesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid [catalytic activity: (S)-(2-hydroxyacyl)glutathione + H(2)O = glutathione + a 2- hydroxy acid anion]; Zn-dependent glyoxylase 1914153 4551827 MUL_1731 Mycobacterium ulcerans Agy99 Zn-dependent glyoxylase YP_905687.1 1913479 D 362242 CDS YP_905688.1 118617356 4551828 1914150..1915412 1 NC_008611.1 catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG; histidyl-tRNA synthetase 1915412 hisS 4551828 hisS Mycobacterium ulcerans Agy99 histidyl-tRNA synthetase YP_905688.1 1914150 D 362242 CDS YP_905689.1 118617357 4551830 1917222..1918250 1 NC_008611.1 May be regulated by LexA; cytoplasmic protein; hypothetical protein 1918250 4551830 MUL_1734 Mycobacterium ulcerans Agy99 hypothetical protein YP_905689.1 1917222 D 362242 CDS YP_905690.1 118617358 4551832 complement(1919880..1920782) 1 NC_008611.1 Contains patatin domain. This family consists of various patatin glycoproteins from plants. The patatin protein accounts for up to 40% of the total soluble protein in potato tubers. Patatin is a storage protein but it also has the enzymatic activity of lipid acyl hydrolase.; cytoplasmic protein; patatin-like phospholipase catalysing the cleavage of fatty acids from membrane lipids.; alpha-beta hydrolase superfamily esterase 1920782 4551832 MUL_1736 Mycobacterium ulcerans Agy99 alpha-beta hydrolase superfamily esterase YP_905690.1 1919880 R 362242 CDS YP_905691.1 118617359 4551833 complement(1921247..1921789) 1 NC_008611.1 cytoplasmic protein; function unknown. contains Cdd pfam01381, HTH_3, helix-turn-helix of DNA binding proteins.; transcriptional regulator 1921789 4551833 MUL_1737 Mycobacterium ulcerans Agy99 transcriptional regulator YP_905691.1 1921247 R 362242 CDS YP_905692.1 118617360 4551835 1922733..1923623 1 NC_008611.1 cytoplasmic protein; involved in biosynthesis of diaminopimelate and lysine from aspartate semialdehyde (at the first step) [catalytic activity: l-aspartate 4-semialdehyde + pyruvate = dihydrodipicolinate + 2 H(2)O]; dihydrodipicolinate synthase DapA_1 1923623 dapA_1 4551835 dapA_1 Mycobacterium ulcerans Agy99 dihydrodipicolinate synthase DapA_1 YP_905692.1 1922733 D 362242 CDS YP_905693.1 118617361 4551836 complement(1923673..1924557) 1 NC_008611.1 membrane protein; membrane glycine rich protein 1924557 4551836 MUL_1740 Mycobacterium ulcerans Agy99 membrane glycine rich protein YP_905693.1 1923673 R 362242 CDS YP_905694.1 118617362 4551837 complement(1924619..1925134) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; hypothetical protein 1925134 4551837 MUL_1741 Mycobacterium ulcerans Agy99 hypothetical protein YP_905694.1 1924619 R 362242 CDS YP_905695.1 118617363 4551838 complement(1925153..1925893) 1 NC_008611.1 ketopantoate reductase; catalyzes the NADPH reduction of ketopantoate to pantoate; functions in pantothenate (vitamin B5) biosynthesis; 2-dehydropantoate 2-reductase 1925893 apbA_1 4551838 apbA_1 Mycobacterium ulcerans Agy99 2-dehydropantoate 2-reductase YP_905695.1 1925153 R 362242 CDS YP_905696.1 118617364 4551839 1926132..1927913 1 NC_008611.1 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes; aspartyl-tRNA synthetase 1927913 aspS 4551839 aspS Mycobacterium ulcerans Agy99 aspartyl-tRNA synthetase YP_905696.1 1926132 D 362242 CDS YP_905697.1 118617365 4551842 complement(1929243..1929650) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 1929650 4551842 MUL_1745 Mycobacterium ulcerans Agy99 hypothetical protein YP_905697.1 1929243 R 362242 CDS YP_905698.1 118617366 4551785 1929718..1930728 1 NC_008611.1 cytoplasmic protein; function unknown, but contains Cdd COG1305, transglutaminase-like enzymes, putative cysteine proteases; hypothetical protein 1930728 4551785 MUL_1746 Mycobacterium ulcerans Agy99 hypothetical protein YP_905698.1 1929718 D 362242 CDS YP_905699.1 118617367 4551786 1930721..1931776 1 NC_008611.1 cytoplasmic protein; hypothetical protein 1931776 4551786 MUL_1747 Mycobacterium ulcerans Agy99 hypothetical protein YP_905699.1 1930721 D 362242 CDS YP_905700.1 118617368 4551787 complement(1931800..1934487) 1 NC_008611.1 membrane protein; hypothetical protein 1934487 4551787 MUL_1748 Mycobacterium ulcerans Agy99 hypothetical protein YP_905700.1 1931800 R 362242 CDS YP_905701.1 118617369 4551788 complement(1934521..1936188) 1 NC_008611.1 cytoplasmic protein; function unknown, in general transglutaminases are enzymes that establish covalent links between proteins. a subset of transglutaminase homologues appear to catalyse the reverse reaction, the hydrolysis of peptide bonds.; transglutaminase family protein 1936188 4551788 MUL_1749 Mycobacterium ulcerans Agy99 transglutaminase family protein YP_905701.1 1934521 R 362242 CDS YP_905702.1 118617370 4551789 complement(1936324..1937430) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; proline and glycine rich transmembrane protein 1937430 4551789 MUL_1750 Mycobacterium ulcerans Agy99 proline and glycine rich transmembrane protein YP_905702.1 1936324 R 362242 CDS YP_905703.1 118617371 4551790 1937621..1938979 1 NC_008611.1 cytoplasmic protein; recombination factor protein RarA 1938979 4551790 MUL_1751 Mycobacterium ulcerans Agy99 recombination factor protein RarA YP_905703.1 1937621 D 362242 CDS YP_905704.1 118617372 4551791 complement(1939025..1939846) 1 NC_008611.1 cytoplasmic protein; function unknown, thought to be involved in the persistence in the host.; hypothetical protein 1939846 4551791 MUL_1752 Mycobacterium ulcerans Agy99 hypothetical protein YP_905704.1 1939025 R 362242 CDS YP_905705.1 118617373 4551792 1939862..1940263 1 NC_008611.1 cytoplasmic protein; hypothetical protein 1940263 4551792 MUL_1753 Mycobacterium ulcerans Agy99 hypothetical protein YP_905705.1 1939862 D 362242 CDS YP_905706.1 118617374 4551793 1940382..1943087 1 NC_008611.1 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; alanyl-tRNA synthetase 1943087 alaS 4551793 alaS Mycobacterium ulcerans Agy99 alanyl-tRNA synthetase YP_905706.1 1940382 D 362242 CDS YP_905707.1 118617375 4551794 1943088..1943600 1 NC_008611.1 similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function; Holliday junction resolvase-like protein 1943600 4551794 MUL_1755 Mycobacterium ulcerans Agy99 Holliday junction resolvase-like protein YP_905707.1 1943088 D 362242 CDS YP_905708.1 118617376 4551795 1943593..1944849 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; hypothetical protein 1944849 4551795 MUL_1756 Mycobacterium ulcerans Agy99 hypothetical protein YP_905708.1 1943593 D 362242 CDS YP_905709.1 118617377 4551796 1944846..1945679 1 NC_008611.1 AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate; shikimate 5-dehydrogenase 1945679 aroE 4551796 aroE Mycobacterium ulcerans Agy99 shikimate 5-dehydrogenase YP_905709.1 1944846 D 362242 CDS YP_905710.1 118617378 4551798 1946212..1947435 1 NC_008611.1 catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis; chorismate synthase 1947435 aroF 4551798 aroF Mycobacterium ulcerans Agy99 chorismate synthase YP_905710.1 1946212 D 362242 CDS YP_905711.1 118617379 4551799 1947444..1947998 1 NC_008611.1 catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis; shikimate kinase 1947998 aroK 4551799 aroK Mycobacterium ulcerans Agy99 shikimate kinase YP_905711.1 1947444 D 362242 CDS YP_905712.1 118617380 4551800 1947995..1949083 1 NC_008611.1 catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis; 3-dehydroquinate synthase 1949083 aroB 4551800 aroB Mycobacterium ulcerans Agy99 3-dehydroquinate synthase YP_905712.1 1947995 D 362242 CDS YP_905713.1 118617381 4551801 1949080..1949520 1 NC_008611.1 catalyzes the formation of 3-dehydroshikimate from 3-dehydroquinate in chorismate biosynthesis; 3-dehydroquinate dehydratase 1949520 aroD 4551801 aroD Mycobacterium ulcerans Agy99 3-dehydroquinate dehydratase YP_905713.1 1949080 D 362242 CDS YP_905714.1 118617382 4551802 complement(1949517..1950275) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; transmembrane protein 1950275 4551802 MUL_1763 Mycobacterium ulcerans Agy99 transmembrane protein YP_905714.1 1949517 R 362242 CDS YP_905715.1 118617383 4551803 1950309..1951427 1 NC_008611.1 cytoplasmic protein; function unknown, hydrolyses peptides.; cytoplasmic peptidase PepQ 1951427 pepQ 4551803 pepQ Mycobacterium ulcerans Agy99 cytoplasmic peptidase PepQ YP_905715.1 1950309 D 362242 CDS YP_905716.1 118617384 4551804 1951442..1952005 1 NC_008611.1 Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA; elongation factor P 1952005 efp 4551804 efp Mycobacterium ulcerans Agy99 elongation factor P YP_905716.1 1951442 D 362242 CDS YP_905717.1 118617385 4551730 1952008..1952529 1 NC_008611.1 Regulates rRNA biosynthesis by transcriptional antitermination; transcription antitermination protein NusB 1952529 nusB 4551730 nusB Mycobacterium ulcerans Agy99 transcription antitermination protein NusB YP_905717.1 1952008 D 362242 CDS YP_905718.1 118617386 4551731 1952523..1952936 1 NC_008611.1 secreted protein; hypothetical protein 1952936 4551731 MUL_1767 Mycobacterium ulcerans Agy99 hypothetical protein YP_905718.1 1952523 D 362242 CDS YP_905719.1 118617387 4551733 complement(1955954..1957174) 1 NC_008611.1 cytoplasmic protein; function unknown, probably involved in cellular metabolism.; oxidoreductase 1957174 4551733 MUL_1770 Mycobacterium ulcerans Agy99 oxidoreductase YP_905719.1 1955954 R 362242 CDS YP_905720.1 118617388 4551734 complement(1957220..1957792) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 1957792 4551734 MUL_1771 Mycobacterium ulcerans Agy99 hypothetical protein YP_905720.1 1957220 R 362242 CDS YP_905721.1 118617389 4551735 complement(1957808..1959130) 1 NC_008611.1 cytoplasmic protein; function unknown.; beta-lactamase 1959130 4551735 MUL_1772 Mycobacterium ulcerans Agy99 beta-lactamase YP_905721.1 1957808 R 362242 CDS YP_905722.1 118617390 4551736 1959260..1960300 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; lipoprotein LprF 1960300 lprF 4551736 lprF Mycobacterium ulcerans Agy99 lipoprotein LprF YP_905722.1 1959260 D 362242 CDS YP_905723.1 118617391 4551737 1960348..1962030 1 NC_008611.1 membrane protein; hypothetical protein 1962030 4551737 MUL_1774 Mycobacterium ulcerans Agy99 hypothetical protein YP_905723.1 1960348 D 362242 CDS YP_905724.1 118617392 4551738 1962027..1963208 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; membrane protein; chalcone/stilbene synthase 1963208 4551738 MUL_1775 Mycobacterium ulcerans Agy99 chalcone/stilbene synthase YP_905724.1 1962027 D 362242 CDS YP_905725.1 118617393 4551739 1963268..1964500 1 NC_008611.1 cytoplasmic protein; involved in sulfation: activity towards typical ceramide glycolipids and trehalose glycolipids.; glycolipid sulfotransferase 1964500 4551739 MUL_1776 Mycobacterium ulcerans Agy99 glycolipid sulfotransferase YP_905725.1 1963268 D 362242 CDS YP_905726.1 118617394 4551740 1964382..1965314 1 NC_008611.1 cytoplasmic protein; involved in sulfation: activity towards typical ceramide glycolipids and trehalose glycolipids.; glycolipid sulfotransferase 1965314 4551740 MUL_1777 Mycobacterium ulcerans Agy99 glycolipid sulfotransferase YP_905726.1 1964382 D 362242 CDS YP_905727.1 118617395 4551742 1966139..1966702 1 NC_008611.1 regulates pyrimidine biosynthesis by binding to the mRNA of the pyr genes, also has been shown to have uracil phosphoribosyltransferase activity; bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase 1966702 pyrR 4551742 pyrR Mycobacterium ulcerans Agy99 bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase YP_905727.1 1966139 D 362242 CDS YP_905728.1 118617396 4551743 1966699..1967661 1 NC_008611.1 catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis; aspartate carbamoyltransferase catalytic subunit 1967661 pyrB 4551743 pyrB Mycobacterium ulcerans Agy99 aspartate carbamoyltransferase catalytic subunit YP_905728.1 1966699 D 362242 CDS YP_905729.1 118617397 4551744 1967658..1968950 1 NC_008611.1 catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis; dihydroorotase 1968950 pyrC 4551744 pyrC Mycobacterium ulcerans Agy99 dihydroorotase YP_905729.1 1967658 D 362242 CDS YP_905730.1 118617398 4551745 1968947..1969456 1 NC_008611.1 secreted protein 1969456 4551745 MUL_1782 Mycobacterium ulcerans Agy99 secreted protein YP_905730.1 1968947 D 362242 CDS YP_905731.1 118617399 4551746 1969453..1970580 1 NC_008611.1 catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers; carbamoyl phosphate synthase small subunit 1970580 carA 4551746 carA Mycobacterium ulcerans Agy99 carbamoyl phosphate synthase small subunit YP_905731.1 1969453 D 362242 CDS YP_905732.1 118617400 4551747 1970672..1974037 1 NC_008611.1 four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity; carbamoyl phosphate synthase large subunit 1974037 carB 4551747 carB Mycobacterium ulcerans Agy99 carbamoyl phosphate synthase large subunit YP_905732.1 1970672 D 362242 CDS YP_905733.1 118617401 4551748 1974034..1974870 1 NC_008611.1 type 2 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase; orotidine 5'-phosphate decarboxylase 1974870 pyrF 4551748 pyrF Mycobacterium ulcerans Agy99 orotidine 5'-phosphate decarboxylase YP_905733.1 1974034 D 362242 CDS YP_905734.1 118617402 4551711 1975835..1976152 1 NC_008611.1 Detected in the cytoplamic fraction by LCMSMS. Also detected in the membrane fraction by proteomics (LC- MS/MS); cytoplasmic protein; integration host factor MihF 1976152 mihF 4551711 mihF Mycobacterium ulcerans Agy99 integration host factor MihF YP_905734.1 1975835 D 362242 CDS YP_905735.1 118617403 4551712 1976249..1976875 1 NC_008611.1 Essential for recycling GMP and indirectly, cGMP; guanylate kinase 1976875 gmk 4551712 gmk Mycobacterium ulcerans Agy99 guanylate kinase YP_905735.1 1976249 D 362242 CDS YP_905736.1 118617404 4551713 1976962..1977294 1 NC_008611.1 Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits; DNA-directed RNA polymerase subunit omega 1977294 rpoZ 4551713 rpoZ Mycobacterium ulcerans Agy99 DNA-directed RNA polymerase subunit omega YP_905736.1 1976962 D 362242 CDS YP_905737.1 118617405 4551714 1977310..1978551 1 NC_008611.1 catalyzes the conjugation of cysteine to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, which is then decarboxylated to form 4'-phosphopantotheine; bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase 1978551 dfp 4551714 dfp Mycobacterium ulcerans Agy99 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase YP_905737.1 1977310 D 362242 CDS YP_905738.1 118617406 4551715 1978680..1979891 1 NC_008611.1 catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase; S-adenosylmethionine synthetase 1979891 metK 4551715 metK Mycobacterium ulcerans Agy99 S-adenosylmethionine synthetase YP_905738.1 1978680 D 362242 CDS YP_905739.1 118617407 4551716 complement(1979973..1980581) 1 NC_008611.1 secreted protein; hypothetical protein 1980581 4551716 MUL_1792 Mycobacterium ulcerans Agy99 hypothetical protein YP_905739.1 1979973 R 362242 CDS YP_905740.1 118617408 4551717 complement(1980641..1982098) 1 NC_008611.1 cytoplasmic protein; function unknown, probably involved in cellular metabolism; monoxygenase 1982098 4551717 MUL_1793 Mycobacterium ulcerans Agy99 monoxygenase YP_905740.1 1980641 R 362242 CDS YP_905741.1 118617409 4551718 complement(1982270..1983241) 1 NC_008611.1 cytoplasmic protein; lipase LipH 1983241 lipH 4551718 lipH Mycobacterium ulcerans Agy99 lipase LipH YP_905741.1 1982270 R 362242 CDS YP_905742.1 118617410 4551719 complement(1983268..1984242) 1 NC_008611.1 cytoplasmic protein; lipase LipI 1984242 lipI 4551719 lipI Mycobacterium ulcerans Agy99 lipase LipI YP_905742.1 1983268 R 362242 CDS YP_905743.1 118617411 4551720 1984193..1984978 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; membrane protein 1984978 4551720 MUL_1796 Mycobacterium ulcerans Agy99 membrane protein YP_905743.1 1984193 D 362242 CDS YP_905744.1 118617412 4551721 1985089..1987035 1 NC_008611.1 binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity; primosome assembly protein PriA 1987035 priA 4551721 priA Mycobacterium ulcerans Agy99 primosome assembly protein PriA YP_905744.1 1985089 D 362242 CDS YP_905745.1 118617413 4551722 complement(1987053..1987877) 1 NC_008611.1 cytoplasmic protein; causes methylation; methyltransferase 1987877 4551722 MUL_1798 Mycobacterium ulcerans Agy99 methyltransferase YP_905745.1 1987053 R 362242 CDS YP_905746.1 118617414 4551723 complement(1988114..1989160) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 1989160 4551723 MUL_1799 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_905746.1 1988114 R 362242 CDS YP_905747.1 118617415 4551724 1989129..1989959 1 NC_008611.1 cytoplasmic protein; involved in transcriptional mechanism; transcriptional regulatory protein 1989959 4551724 MUL_1800 Mycobacterium ulcerans Agy99 transcriptional regulatory protein YP_905747.1 1989129 D 362242 CDS YP_905748.1 118617416 4551725 complement(1990082..1990906) 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; causes methylation; methyltransferase 1990906 4551725 MUL_1801 Mycobacterium ulcerans Agy99 methyltransferase YP_905748.1 1990082 R 362242 CDS YP_905749.1 118617417 4551726 1991108..1992046 1 NC_008611.1 modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth; methionyl-tRNA formyltransferase 1992046 fmt 4551726 fmt Mycobacterium ulcerans Agy99 methionyl-tRNA formyltransferase YP_905749.1 1991108 D 362242 CDS YP_905750.1 118617418 4551727 1992115..1993488 1 NC_008611.1 cytoplasmic protein; Fmu protein 1993488 fmu 4551727 fmu Mycobacterium ulcerans Agy99 Fmu protein YP_905750.1 1992115 D 362242 CDS YP_905751.1 118617419 4551728 1993546..1994244 1 NC_008611.1 catalyzes the interconversion of D-ribulose 5-phosphate to xylulose 5-phosphate; ribulose-phosphate 3-epimerase 1994244 rpe 4551728 rpe Mycobacterium ulcerans Agy99 ribulose-phosphate 3-epimerase YP_905751.1 1993546 D 362242 CDS YP_905752.1 118617420 4551729 1994252..1995271 1 NC_008611.1 Detected in the membrane fraction by proteomics (2D- LC-MS/MS); membrane protein; involved in riboflavin biosynthesis (at the second and third steps) converts 2,5-diamino-6-(ribosylamino)- 4(3H)-pyrimidinone 5'-phosphate into 5-amino-6- (ribosylamino)-2,4(1H,3H)-pyrimidinedione 5'-phosphate [catalytic activity 1: 2,5-diamino-6-hydroxy-4-(5- phosphoribosylamino)pyrimidine + H(2)O = 5-amino-6-(5- phosphoribosylamino)uracil + NH(3)] [catalytic activity 2: 5-amino-6-(5-phosphoribitylamino)uracil + NADP(+) = 5- amino-6-(5-phosphoribosylamino)uracil + NADPH]; bifunctional riboflavin biosynthesis protein RibG 1995271 ribG 4551729 ribG Mycobacterium ulcerans Agy99 bifunctional riboflavin biosynthesis protein RibG YP_905752.1 1994252 D 362242 CDS YP_905753.1 118617421 4551693 complement(1995276..1996829) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; involved in transport of aminoglycosides and tetracycline across the membrane (export): drug resistance by an export mechanism (conferes resistance to toxic compounds by removing them for the cells) responsible for the translocation of the substrate across the membrane.; aminoglycosides/tetracycline-transport integral membrane protein 1996829 4551693 MUL_1806 Mycobacterium ulcerans Agy99 aminoglycosides/tetracycline-transport integral membrane protein YP_905753.1 1995276 R 362242 CDS YP_905754.1 118617422 4551694 complement(1996829..1997539) 1 NC_008611.1 Detected in the membrane fraction and the cytoplamic fraction by LC.MS/MS.; membrane protein; lipoprotein LprG 1997539 lprG 4551694 lprG Mycobacterium ulcerans Agy99 lipoprotein LprG YP_905754.1 1996829 R 362242 CDS YP_905755.1 118617423 4551695 1997640..1998263 1 NC_008611.1 catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine; riboflavin synthase subunit alpha 1998263 ribC 4551695 ribC Mycobacterium ulcerans Agy99 riboflavin synthase subunit alpha YP_905755.1 1997640 D 362242 CDS YP_905756.1 118617424 4551696 1998402..1999679 1 NC_008611.1 bifunctional enzyme DHBP synthase/GTP cyclohydrolase II; functions in riboflavin synthesis; converts GTP to 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine; converts ribulose 5-phopshate to 3,4-dihydroxy-2-butanone 4-phosphate; bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein 1999679 ribA2 4551696 ribA2 Mycobacterium ulcerans Agy99 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein YP_905756.1 1998402 D 362242 CDS YP_905757.1 118617425 4551697 1999676..2000158 1 NC_008611.1 RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not; 6,7-dimethyl-8-ribityllumazine synthase 2000158 ribH 4551697 ribH Mycobacterium ulcerans Agy99 6,7-dimethyl-8-ribityllumazine synthase YP_905757.1 1999676 D 362242 CDS YP_905758.1 118617426 4551698 2000155..2000625 1 NC_008611.1 membrane protein; hypothetical protein 2000625 4551698 MUL_1811 Mycobacterium ulcerans Agy99 hypothetical protein YP_905758.1 2000155 D 362242 CDS YP_905759.1 118617427 4551699 2000675..2001298 1 NC_008611.1 secreted protein; lipoprotein LprH 2001298 lprH 4551699 lprH Mycobacterium ulcerans Agy99 lipoprotein LprH YP_905759.1 2000675 D 362242 CDS YP_905760.1 118617428 4551700 2001395..2002963 1 NC_008611.1 May be regulated by LexA; Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; 13e12 repeat-containing protein 2002963 4551700 MUL_1813 Mycobacterium ulcerans Agy99 13e12 repeat-containing protein YP_905760.1 2001395 D 362242 CDS YP_905761.1 118617429 4551701 2002891..2004777 1 NC_008611.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision; excinuclease ABC subunit C 2004777 uvrC 4551701 uvrC Mycobacterium ulcerans Agy99 excinuclease ABC subunit C YP_905761.1 2002891 D 362242 CDS YP_905762.1 118617430 4551702 2004774..2005694 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2005694 4551702 MUL_1815 Mycobacterium ulcerans Agy99 hypothetical protein YP_905762.1 2004774 D 362242 CDS YP_905763.1 118617431 4551703 2005691..2006767 1 NC_008611.1 Detected in the cytoplamic fraction.; membrane protein; hypothetical protein 2006767 4551703 MUL_1816 Mycobacterium ulcerans Agy99 hypothetical protein YP_905763.1 2005691 D 362242 CDS YP_905764.1 118617432 4551704 2006764..2007741 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; involved in transcriptional mechanism; transcriptional regulatory protein WhiA 2007741 whiA 4551704 whiA Mycobacterium ulcerans Agy99 transcriptional regulatory protein WhiA YP_905764.1 2006764 D 362242 CDS YP_905765.1 118617433 4551705 2007844..2009226 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2009226 4551705 MUL_1818 Mycobacterium ulcerans Agy99 hypothetical protein YP_905765.1 2007844 D 362242 CDS YP_905766.1 118617434 4551706 complement(2009227..2010504) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); cytoplasmic protein; function unknown, but supposed involved in lipid metabolism; esterase LipO 2010504 lipO 4551706 lipO Mycobacterium ulcerans Agy99 esterase LipO YP_905766.1 2009227 R 362242 CDS YP_905767.1 118617435 4551708 complement(2012138..2012941) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2012941 4551708 MUL_1821 Mycobacterium ulcerans Agy99 hypothetical protein YP_905767.1 2012138 R 362242 CDS YP_905768.1 118617436 4551710 2014207..2014911 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; N-term transposase for IS2404 2014911 4551710 MUL_1823 Mycobacterium ulcerans Agy99 N-term transposase for IS2404 YP_905768.1 2014207 D 362242 CDS YP_905769.1 118617437 4551675 2014936..2015253 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; C-term transposase for IS2404 2015253 4551675 MUL_1824 Mycobacterium ulcerans Agy99 C-term transposase for IS2404 YP_905769.1 2014936 D 362242 CDS YP_905770.1 118617438 4551677 2018316..2019737 1 NC_008611.1 cytoplasmic protein; function unknown, probably involved in cellular metabolism; dehydrogenase 2019737 4551677 MUL_1826 Mycobacterium ulcerans Agy99 dehydrogenase YP_905770.1 2018316 D 362242 CDS YP_905771.1 118617439 4551678 complement(2019745..2020362) 1 NC_008611.1 membrane protein; hypothetical protein 2020362 4551678 MUL_1827 Mycobacterium ulcerans Agy99 hypothetical protein YP_905771.1 2019745 R 362242 CDS YP_905772.1 118617440 4551679 2020646..2021665 1 NC_008611.1 Also detected in the extracellular matrix and the membrane fraction by proteomics.; cytoplasmic protein; involved in second phase of glycolysis (first step) [catalytic activity: D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = 3-phospho-D-glyceroyl phosphate + NADH]; glyceraldehyde 3-phosphate dehydrogenase Gap 2021665 gap 4551679 gap Mycobacterium ulcerans Agy99 glyceraldehyde 3-phosphate dehydrogenase Gap YP_905772.1 2020646 D 362242 CDS YP_905773.1 118617441 4551680 2021678..2022928 1 NC_008611.1 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway; phosphoglycerate kinase 2022928 pgk 4551680 pgk Mycobacterium ulcerans Agy99 phosphoglycerate kinase YP_905773.1 2021678 D 362242 CDS YP_905774.1 118617442 4551681 2022925..2023710 1 NC_008611.1 Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate; triosephosphate isomerase 2023710 tpiA 4551681 tpiA Mycobacterium ulcerans Agy99 triosephosphate isomerase YP_905774.1 2022925 D 362242 CDS YP_905775.1 118617443 4551684 2028316..2029044 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; possibly involved in transcriptional mechanism.; GntR family transcriptional regulator 2029044 4551684 MUL_1833 Mycobacterium ulcerans Agy99 GntR family transcriptional regulator YP_905775.1 2028316 D 362242 CDS YP_905776.1 118617444 4551685 complement(2029078..2029422) 1 NC_008611.1 membrane protein; hypothetical protein 2029422 4551685 MUL_1834 Mycobacterium ulcerans Agy99 hypothetical protein YP_905776.1 2029078 R 362242 CDS YP_905777.1 118617445 4551686 complement(2029580..2029813) 1 NC_008611.1 membrane protein; involved in protein export. participates in a early event of protein translocation.; preprotein translocase subunit SecG 2029813 secG 4551686 secG Mycobacterium ulcerans Agy99 preprotein translocase subunit SecG YP_905777.1 2029580 R 362242 CDS YP_905778.1 118617446 4551687 2029883..2032690 1 NC_008611.1 catalyzes the formation of oxaloacetate from phosphoenolpyruvate; phosphoenolpyruvate carboxylase 2032690 4551687 MUL_1836 Mycobacterium ulcerans Agy99 phosphoenolpyruvate carboxylase YP_905778.1 2029883 D 362242 CDS YP_905779.1 118617447 4551688 complement(2032714..2033865) 1 NC_008611.1 secreted protein; PE-PGRS family protein 2033865 4551688 MUL_1837 Mycobacterium ulcerans Agy99 PE-PGRS family protein YP_905779.1 2032714 R 362242 CDS YP_905780.1 118617448 4551689 complement(2033866..2034981) 1 NC_008611.1 secreted protein; PE-PGRS family protein 2034981 4551689 MUL_1838 Mycobacterium ulcerans Agy99 PE-PGRS family protein YP_905780.1 2033866 R 362242 CDS YP_905781.1 118617449 4551690 complement(2035077..2035475) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2035475 4551690 MUL_1839 Mycobacterium ulcerans Agy99 hypothetical protein YP_905781.1 2035077 R 362242 CDS YP_905782.1 118617450 4551691 complement(2035525..2036268) 1 NC_008611.1 Detected in the cytoplasmic fraction by proteomics.; cytoplasmic protein; involved in pentose phosphate pathway. hydrolysis of 6-phosphogluconolactone to 6- phosphogluconate. [catalytic activity : 6-phospho-D-glucono-1,5-lactone + H(2)O = 6- phospho-D-gluconate]; 6-phosphogluconolactonase DevB 2036268 devB 4551691 devB Mycobacterium ulcerans Agy99 6-phosphogluconolactonase DevB YP_905782.1 2035525 R 362242 CDS YP_905783.1 118617451 4551692 complement(2036265..2037176) 1 NC_008611.1 cytoplasmic protein; may be involved in the functional assembly of glucose 6-phosphate dehydrogenase; OXPP cycle protein OpcA 2037176 opcA 4551692 opcA Mycobacterium ulcerans Agy99 OXPP cycle protein OpcA YP_905783.1 2036265 R 362242 CDS YP_905784.1 118617452 4551662 complement(2037226..2038779) 1 NC_008611.1 catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate; glucose-6-phosphate 1-dehydrogenase 2038779 zwf2 4551662 zwf2 Mycobacterium ulcerans Agy99 glucose-6-phosphate 1-dehydrogenase YP_905784.1 2037226 R 362242 CDS YP_905785.1 118617453 4551663 complement(2038776..2039897) 1 NC_008611.1 catalyzes the reversible formation of D-erythrose 4-phosphate and D-fructose 6-phosphate from sedoheptulose 7-phosphate and D-glyceraldehyde 3-phosphate; transaldolase 2039897 tal 4551663 tal Mycobacterium ulcerans Agy99 transaldolase YP_905785.1 2038776 R 362242 CDS YP_905786.1 118617454 4551664 complement(2039913..2042015) 1 NC_008611.1 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase 2042015 tkt 4551664 tkt Mycobacterium ulcerans Agy99 transketolase YP_905786.1 2039913 R 362242 CDS YP_905787.1 118617455 4551665 2042303..2043277 1 NC_008611.1 converts protoheme IX and farnesyl diphosphate to heme O; protoheme IX farnesyltransferase 2043277 ctaB 4551665 ctaB Mycobacterium ulcerans Agy99 protoheme IX farnesyltransferase YP_905787.1 2042303 D 362242 CDS YP_905788.1 118617456 4551668 2044863..2045909 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 2045909 4551668 MUL_1848 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_905788.1 2044863 D 362242 CDS YP_905789.1 118617457 4551669 2046040..2047374 1 NC_008611.1 cytoplasmic protein; required for the transposition of the insertion element IS2606.; transposase for IS2606 2047374 4551669 MUL_1849 Mycobacterium ulcerans Agy99 transposase for IS2606 YP_905789.1 2046040 D 362242 CDS YP_905790.1 118617458 4551672 complement(2051104..2052150) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 2052150 4551672 MUL_1853 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_905790.1 2051104 R 362242 CDS YP_905791.1 118617459 4551673 2054860..2055870 1 NC_008611.1 cytoplasmic protein; involved in transcriptional mechanism; transcriptional activator protein 2055870 4551673 MUL_1854 Mycobacterium ulcerans Agy99 transcriptional activator protein YP_905791.1 2054860 D 362242 CDS YP_905792.1 118617460 4551674 complement(2056197..2057207) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; catalyzes the one electron reduction of certain quinones [catalytic activity: NADPH + quinone = NADP+ + semiquinone]; quinone reductase Qor 2057207 qor 4551674 qor Mycobacterium ulcerans Agy99 quinone reductase Qor YP_905792.1 2056197 R 362242 CDS YP_905793.1 118617461 4551563 2057206..2058060 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2058060 4551563 MUL_1856 Mycobacterium ulcerans Agy99 hypothetical protein YP_905793.1 2057206 D 362242 CDS YP_905794.1 118617462 4551564 complement(2058010..2058939) 1 NC_008611.1 membrane protein; thought to be involved in active transport of antibiotic across the membrane (export): unidentified antibiotic resistance by an export mechanism. responsible for the translocation of the substrate across the membrane.; antibiotic ABC transporter transmembrane protein 2058939 4551564 MUL_1857 Mycobacterium ulcerans Agy99 antibiotic ABC transporter transmembrane protein YP_905794.1 2058010 R 362242 CDS YP_905795.1 118617463 4551565 complement(2059010..2059798) 1 NC_008611.1 membrane protein; thought to be involved in active transport of antibiotic across the membrane (export): unidentified antibiotic resistance by an export mechanism. responsible for the translocation of the substrate across the membrane.; antibiotic ABC transporter transmembrane protein 2059798 4551565 MUL_1858 Mycobacterium ulcerans Agy99 antibiotic ABC transporter transmembrane protein YP_905795.1 2059010 R 362242 CDS YP_905796.1 118617464 4551566 complement(2059795..2060706) 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; membrane protein; thought to be involved in active transport of antibiotic across the membrane (export): unidentified antibiotic resistance by an export mechanism. responsible for energy coupling to the transport system.; antibiotic ABC transporter ATP-binding protein 2060706 4551566 MUL_1859 Mycobacterium ulcerans Agy99 antibiotic ABC transporter ATP-binding protein YP_905796.1 2059795 R 362242 CDS YP_905797.1 118617465 4551567 complement(2060751..2062568) 1 NC_008611.1 membrane protein; integral membrane protein 2062568 4551567 MUL_1860 Mycobacterium ulcerans Agy99 integral membrane protein YP_905797.1 2060751 R 362242 CDS YP_905798.1 118617466 4551568 2062649..2063434 1 NC_008611.1 cytoplasmic protein; involved in transcriptional mechanism; transcriptional regulatory protein 2063434 4551568 MUL_1861 Mycobacterium ulcerans Agy99 transcriptional regulatory protein YP_905798.1 2062649 D 362242 CDS YP_905799.1 118617467 4551569 2063431..2064876 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2064876 4551569 MUL_1862 Mycobacterium ulcerans Agy99 hypothetical protein YP_905799.1 2063431 D 362242 CDS YP_905800.1 118617468 4551570 2064873..2066072 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; hypothetical protein 2066072 4551570 MUL_1863 Mycobacterium ulcerans Agy99 hypothetical protein YP_905800.1 2064873 D 362242 CDS YP_905801.1 118617469 4551571 2066069..2066851 1 NC_008611.1 Detected in the extracellular matrix, the membrane and the cytoplasmic fractions by proteomics.; membrane protein; thought to be involved in active transport across the membrane. responsible for energy coupling to the transport system.; ABC transporter ATP-binding protein 2066851 4551571 MUL_1864 Mycobacterium ulcerans Agy99 ABC transporter ATP-binding protein YP_905801.1 2066069 D 362242 CDS YP_905802.1 118617470 4551572 2066854..2068107 1 NC_008611.1 cytoplasmic protein; catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, l- selenocysteine, and L-selenocystine to produce L-alanine; cysteine desulfurase Csd 2068107 csd 4551572 csd Mycobacterium ulcerans Agy99 cysteine desulfurase Csd YP_905802.1 2066854 D 362242 CDS YP_905803.1 118617471 4551573 2068110..2068601 1 NC_008611.1 cytoplasmic protein; function unknown, probably involved in cellular metabolism.; nitrogen fixation related protein 2068601 4551573 MUL_1866 Mycobacterium ulcerans Agy99 nitrogen fixation related protein YP_905803.1 2068110 D 362242 CDS YP_905804.1 118617472 4551574 2068594..2068941 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2068941 4551574 MUL_1867 Mycobacterium ulcerans Agy99 hypothetical protein YP_905804.1 2068594 D 362242 CDS YP_905805.1 118617473 4551576 complement(2070605..2072434) 1 NC_008611.1 Detected in the cytoplasmic fraction by proteomics.; cytoplasmic protein; function unknown, but involvement in lipid degradation.; acyl-CoA dehydrogenase FadE15 2072434 fadE15 4551576 fadE15 Mycobacterium ulcerans Agy99 acyl-CoA dehydrogenase FadE15 YP_905805.1 2070605 R 362242 CDS YP_905806.1 118617474 4551577 complement(2072540..2073358) 1 NC_008611.1 membrane protein; PE-PGRS family protein 2073358 4551577 MUL_1870 Mycobacterium ulcerans Agy99 PE-PGRS family protein YP_905806.1 2072540 R 362242 CDS YP_905807.1 118617475 4551580 complement(2074757..2075074) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; C-term transposase for IS2404 2075074 4551580 MUL_1873 Mycobacterium ulcerans Agy99 C-term transposase for IS2404 YP_905807.1 2074757 R 362242 CDS YP_905808.1 118617476 4551581 complement(2075099..2075803) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; N-term transposase for IS2404 2075803 4551581 MUL_1874 Mycobacterium ulcerans Agy99 N-term transposase for IS2404 YP_905808.1 2075099 R 362242 CDS YP_905809.1 118617477 4551546 2077472..2077711 1 NC_008611.1 cytoplasmic protein; involved in electron transfer system for ribonucleotide reductase system NRDEF.; glutaredoxin electron transport component of NRDEF (glutaredoxin-like protein) NrdH 2077711 nrdH 4551546 nrdH Mycobacterium ulcerans Agy99 glutaredoxin electron transport component of NRDEF (glutaredoxin-like protein) NrdH YP_905809.1 2077472 D 362242 CDS YP_905810.1 118617478 4551547 2077755..2078216 1 NC_008611.1 in Salmonella NrdI has a stimulatory effect on the ribonucleotide reductase activity of NrdH with NrdEF; ribonucleotide reductase stimulatory protein 2078216 nrdI 4551547 nrdI Mycobacterium ulcerans Agy99 ribonucleotide reductase stimulatory protein YP_905810.1 2077755 D 362242 CDS YP_905811.1 118617479 4551548 2078270..2080351 1 NC_008611.1 Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha 2080351 nrdE 4551548 nrdE Mycobacterium ulcerans Agy99 ribonucleotide-diphosphate reductase subunit alpha YP_905811.1 2078270 D 362242 CDS YP_905812.1 118617480 4551549 2080466..2081209 1 NC_008611.1 cytoplasmic protein; involved in transcriptional mechanism; AsnC family transcriptional regulator 2081209 4551549 MUL_1879 Mycobacterium ulcerans Agy99 AsnC family transcriptional regulator YP_905812.1 2080466 D 362242 CDS YP_905813.1 118617481 4551550 2081328..2082878 1 NC_008611.1 cytoplasmic protein; function unknown, involved in cellular metabolism.; monooxygenase 2082878 4551550 MUL_1880 Mycobacterium ulcerans Agy99 monooxygenase YP_905813.1 2081328 D 362242 CDS YP_905814.1 118617482 4551551 complement(2082868..2083407) 1 NC_008611.1 cytoplasmic protein; involved in transcriptional mechanism.; transcriptional regulatory protein 2083407 4551551 MUL_1881 Mycobacterium ulcerans Agy99 transcriptional regulatory protein YP_905814.1 2082868 R 362242 CDS YP_905815.1 118617483 4551552 complement(2083391..2083837) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2083837 4551552 MUL_1882 Mycobacterium ulcerans Agy99 hypothetical protein YP_905815.1 2083391 R 362242 CDS YP_905816.1 118617484 4551553 2084047..2085021 1 NC_008611.1 B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE; ribonucleotide-diphosphate reductase subunit beta 2085021 nrdF 4551553 nrdF Mycobacterium ulcerans Agy99 ribonucleotide-diphosphate reductase subunit beta YP_905816.1 2084047 D 362242 CDS YP_905817.1 118617485 4551554 2085188..2085532 1 NC_008611.1 Detected in the cytoplasmic and secreted fractions by 2D-LC-MS/MS.; cytoplasmic protein; hypothetical protein 2085532 4551554 MUL_1884 Mycobacterium ulcerans Agy99 hypothetical protein YP_905817.1 2085188 D 362242 CDS YP_905818.1 118617486 4551555 complement(2085521..2086561) 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; alcohol dehydrogenase catalyzes the reversible oxidation of ethanol to acetaldehyde with the concomitant reduction of NAD: ethanol + NAD = acetaldehyde + NADH. belongs to the zinc-containing 'long-chain' alcohol dehydrogenases.; NADP-dependent alcohol dehydrogenase Adh 2086561 adh 4551555 adh Mycobacterium ulcerans Agy99 NADP-dependent alcohol dehydrogenase Adh YP_905818.1 2085521 R 362242 CDS YP_905819.1 118617487 4551556 complement(2086695..2087789) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; may be involved in active transport of FeIII- decitrate across the membrane (import); FEIII-dicitrate-binding periplasmic lipoprotein FecB 2087789 fecB 4551556 fecB Mycobacterium ulcerans Agy99 FEIII-dicitrate-binding periplasmic lipoprotein FecB YP_905819.1 2086695 R 362242 CDS YP_905820.1 118617488 4551557 2087968..2089689 1 NC_008611.1 Detected in the membrane fraction by proteomics.; cytoplasmic protein; cytochrome C oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. electrons originating in cytochrome C are transferred via the copper a center of subunit 2 and HemE a of subunit 1 to the bimetallic center formed by HemE A3 and copper B [catalytic activity: 4 ferrocytochrome C + O(2) = 2 H(2)O + 4 ferricytochrome C]; cytochrome C oxidase polypeptide I CtaD 2089689 ctaD 4551557 ctaD Mycobacterium ulcerans Agy99 cytochrome C oxidase polypeptide I CtaD YP_905820.1 2087968 D 362242 CDS YP_905821.1 118617489 4551558 2089748..2090977 1 NC_008611.1 cytoplasmic protein; generates serine from phosphoserine [catalytic activity: phosphoserine + H(2)O = serine + phosphate]; phosphoserine phosphatase SerB2 2090977 serB2 4551558 serB2 Mycobacterium ulcerans Agy99 phosphoserine phosphatase SerB2 YP_905821.1 2089748 D 362242 CDS YP_905822.1 118617490 4551560 complement(2091390..2092436) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 2092436 4551560 MUL_1890 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_905822.1 2091390 R 362242 CDS YP_905823.1 118617491 4551561 2092829..2093308 1 NC_008611.1 cytoplasmic protein; function unknown, probably involved in cellular metabolism.; oxidoreductase 2093308 4551561 MUL_1891 Mycobacterium ulcerans Agy99 oxidoreductase YP_905823.1 2092829 D 362242 CDS YP_905824.1 118617492 4551562 2093373..2095283 1 NC_008611.1 membrane protein; function unknown, probably involved in cellular metabolism.; oxidoreductase 2095283 4551562 MUL_1892 Mycobacterium ulcerans Agy99 oxidoreductase YP_905824.1 2093373 D 362242 CDS YP_905825.1 118617493 4551507 2095289..2096239 1 NC_008611.1 membrane protein; involved in hydrogen metabolism; FHL pathway.; formate hydrogenlyase HycD 2096239 hycD 4551507 hycD Mycobacterium ulcerans Agy99 formate hydrogenlyase HycD YP_905825.1 2095289 D 362242 CDS YP_905826.1 118617494 4551508 2096244..2096906 1 NC_008611.1 membrane protein; involved in hydrogen metabolism.; hydrogenase HycP 2096906 hycP 4551508 hycP Mycobacterium ulcerans Agy99 hydrogenase HycP YP_905826.1 2096244 D 362242 CDS YP_905827.1 118617495 4551509 2096906..2098372 1 NC_008611.1 membrane protein; possibly involved in hydrogen metabolism.; hydrogenase HycQ 2098372 hycQ 4551509 hycQ Mycobacterium ulcerans Agy99 hydrogenase HycQ YP_905827.1 2096906 D 362242 CDS YP_905828.1 118617496 4551511 2099963..2100805 1 NC_008611.1 membrane protein; thought to be involved in active transport of undeterminated substrate (possibly iron) across the membrane. responsible for energy coupling to the transport system.; ABC transporter ATP-binding protein 2100805 4551511 MUL_1897 Mycobacterium ulcerans Agy99 ABC transporter ATP-binding protein YP_905828.1 2099963 D 362242 CDS YP_905829.1 118617497 4551512 2100802..2101644 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2101644 4551512 MUL_1898 Mycobacterium ulcerans Agy99 hypothetical protein YP_905829.1 2100802 D 362242 CDS YP_905830.1 118617498 4551513 2101641..2102414 1 NC_008611.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 2102414 echA17 4551513 echA17 Mycobacterium ulcerans Agy99 enoyl-CoA hydratase YP_905830.1 2101641 D 362242 CDS YP_905831.1 118617499 4551514 2102425..2103408 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2103408 4551514 MUL_1900 Mycobacterium ulcerans Agy99 hypothetical protein YP_905831.1 2102425 D 362242 CDS YP_905832.1 118617500 4551515 2103573..2104610 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2104610 4551515 MUL_1901 Mycobacterium ulcerans Agy99 hypothetical protein YP_905832.1 2103573 D 362242 CDS YP_905833.1 118617501 4551516 2104685..2105587 1 NC_008611.1 C-term extended due to frame shift mutation. This CDS now overlaps d/s CDS.; Detected in the secreted protein fraction by 2D-LC- MS/MS.; secreted protein; hypothetical protein 2105587 4551516 MUL_1902 Mycobacterium ulcerans Agy99 hypothetical protein YP_905833.1 2104685 D 362242 CDS YP_905834.1 118617502 4551517 complement(2105374..2105763) 1 NC_008611.1 overlaps neigbouring CDS due to frame shift mutation that extends MUL_1902.; cytoplasmic protein; hypothetical protein 2105763 4551517 MUL_5115 Mycobacterium ulcerans Agy99 hypothetical protein YP_905834.1 2105374 R 362242 CDS YP_905835.1 118617503 4551518 complement(2105780..2106847) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; hypothetical protein 2106847 4551518 MUL_1903 Mycobacterium ulcerans Agy99 hypothetical protein YP_905835.1 2105780 R 362242 CDS YP_905836.1 118617504 4551519 2107273..2108010 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; function unknown, possibly involved in cellular metabolism.; transferase 2108010 4551519 MUL_1904 Mycobacterium ulcerans Agy99 transferase YP_905836.1 2107273 D 362242 CDS YP_905837.1 118617505 4551520 complement(2108031..2108810) 1 NC_008611.1 membrane protein; function unknown; probably involved in lipid metabolism.; lysophospholipase 2108810 4551520 MUL_1905 Mycobacterium ulcerans Agy99 lysophospholipase YP_905837.1 2108031 R 362242 CDS YP_905838.1 118617506 4551521 complement(2108835..2109380) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; hypothetical protein 2109380 4551521 MUL_1906 Mycobacterium ulcerans Agy99 hypothetical protein YP_905838.1 2108835 R 362242 CDS YP_905839.1 118617507 4551522 complement(2109507..2110850) 1 NC_008611.1 cytoplasmic protein; function unknown, possible role in DNA replication, recombination, and repair.; DNA photolyase, PhrI 2110850 phrI 4551522 phrI Mycobacterium ulcerans Agy99 DNA photolyase, PhrI YP_905839.1 2109507 R 362242 CDS YP_905840.1 118617508 4551523 complement(2110859..2111338) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; function unknown. possibly involved in signal transduction mechanisms.; tryptophan-rich sensory protein 2111338 4551523 MUL_1908 Mycobacterium ulcerans Agy99 tryptophan-rich sensory protein YP_905840.1 2110859 R 362242 CDS YP_905841.1 118617509 4551524 complement(2111335..2113449) 1 NC_008611.1 secreted protein; function unknown. thought to be involved in drug export.; transmembrane transport protein 2113449 4551524 MUL_1909 Mycobacterium ulcerans Agy99 transmembrane transport protein YP_905841.1 2111335 R 362242 CDS YP_905842.1 118617510 4551489 2115519..2116223 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; N-term transposase for IS2404 2116223 4551489 MUL_1912 Mycobacterium ulcerans Agy99 N-term transposase for IS2404 YP_905842.1 2115519 D 362242 CDS YP_905843.1 118617511 4551490 2116248..2116565 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; C-term transposase for IS2404 2116565 4551490 MUL_1913 Mycobacterium ulcerans Agy99 C-term transposase for IS2404 YP_905843.1 2116248 D 362242 CDS YP_905844.1 118617512 4551491 complement(2116864..2117271) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2117271 4551491 MUL_1914 Mycobacterium ulcerans Agy99 hypothetical protein YP_905844.1 2116864 R 362242 CDS YP_905845.1 118617513 4551493 2118274..2118969 1 NC_008611.1 membrane protein; hypothetical protein 2118969 4551493 MUL_1916 Mycobacterium ulcerans Agy99 hypothetical protein YP_905845.1 2118274 D 362242 CDS YP_905846.1 118617514 4551495 2120386..2121372 1 NC_008611.1 Detected in the cytoplamic fraction by LCMSMS; cytoplasmic protein; function unknown, probably involved in cellular metabolism.; dehydrogenase/reductase 2121372 4551495 MUL_1918 Mycobacterium ulcerans Agy99 dehydrogenase/reductase YP_905846.1 2120386 D 362242 CDS YP_905847.1 118617515 4551496 complement(2121369..2122613) 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; function unknown, possibly involved in cellular metabolism.; transferase 2122613 4551496 MUL_1919 Mycobacterium ulcerans Agy99 transferase YP_905847.1 2121369 R 362242 CDS YP_905848.1 118617516 4551497 complement(2122705..2124300) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2124300 4551497 MUL_1920 Mycobacterium ulcerans Agy99 hypothetical protein YP_905848.1 2122705 R 362242 CDS YP_905849.1 118617517 4551498 complement(2124297..2125115) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2125115 4551498 MUL_1921 Mycobacterium ulcerans Agy99 hypothetical protein YP_905849.1 2124297 R 362242 CDS YP_905850.1 118617518 4551499 2125388..2126179 1 NC_008611.1 Detected in the cytoplasmic, the membrane and the extracellular matrix fractions by proteomics.; cytoplasmic protein; the electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. it transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase); electron transfer flavoprotein (beta-subunit) FixA 2126179 fixA 4551499 fixA Mycobacterium ulcerans Agy99 electron transfer flavoprotein (beta-subunit) FixA YP_905850.1 2125388 D 362242 CDS YP_905851.1 118617519 4551500 2126227..2127183 1 NC_008611.1 Detected in the cytoplasmic fraction by LC-MS/MS. Also detected in the extracellular matrix and the membrane fraction by proteomics.; cytoplasmic protein; the electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. it transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase); electron transfer flavoprotein (alpha-subunit) FixB 2127183 fixB 4551500 fixB Mycobacterium ulcerans Agy99 electron transfer flavoprotein (alpha-subunit) FixB YP_905851.1 2126227 D 362242 CDS YP_905852.1 118617520 4551501 2127284..2128144 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2128144 4551501 MUL_1924 Mycobacterium ulcerans Agy99 hypothetical protein YP_905852.1 2127284 D 362242 CDS YP_905853.1 118617521 4551502 2128144..2128980 1 NC_008611.1 membrane protein; hypothetical protein 2128980 4551502 MUL_1925 Mycobacterium ulcerans Agy99 hypothetical protein YP_905853.1 2128144 D 362242 CDS YP_905854.1 118617522 4551504 2129621..2130802 1 NC_008611.1 cytoplasmic protein; catalyzes the removal of elemental sulfur from cysteine to produce alanine.; cysteine desulfurase IscS 2130802 iscS 4551504 iscS Mycobacterium ulcerans Agy99 cysteine desulfurase IscS YP_905854.1 2129621 D 362242 CDS YP_905855.1 118617523 4551505 2130799..2131890 1 NC_008611.1 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs; tRNA-specific 2-thiouridylase MnmA 2131890 mnmA 4551505 mnmA Mycobacterium ulcerans Agy99 tRNA-specific 2-thiouridylase MnmA YP_905855.1 2130799 D 362242 CDS YP_905856.1 118617524 4551506 complement(2131887..2132516) 1 NC_008611.1 secreted protein; lipoprotein LpqA 2132516 lpqA 4551506 lpqA Mycobacterium ulcerans Agy99 lipoprotein LpqA YP_905856.1 2131887 R 362242 CDS YP_905857.1 118617525 4551271 2132612..2133625 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2133625 4551271 MUL_1930 Mycobacterium ulcerans Agy99 hypothetical protein YP_905857.1 2132612 D 362242 CDS YP_905858.1 118617526 4551273 2135365..2136411 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 2136411 4551273 MUL_1932 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_905858.1 2135365 D 362242 CDS YP_905859.1 118617527 4551274 2137125..2139176 1 NC_008611.1 this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB; NAD-dependent DNA ligase LigA 2139176 ligA 4551274 ligA Mycobacterium ulcerans Agy99 NAD-dependent DNA ligase LigA YP_905859.1 2137125 D 362242 CDS YP_905860.1 118617528 4551275 2139237..2139842 1 NC_008611.1 cytoplasmic protein; possibly involved in a transcriptional mechanism; regulatory protein 2139842 4551275 MUL_1934 Mycobacterium ulcerans Agy99 regulatory protein YP_905860.1 2139237 D 362242 CDS YP_905861.1 118617529 4551276 2140039..2140443 1 NC_008611.1 membrane protein; hypothetical protein 2140443 4551276 MUL_1935 Mycobacterium ulcerans Agy99 hypothetical protein YP_905861.1 2140039 D 362242 CDS YP_905862.1 118617530 4551278 complement(2143348..2144010) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2144010 4551278 MUL_1937 Mycobacterium ulcerans Agy99 hypothetical protein YP_905862.1 2143348 R 362242 CDS YP_905863.1 118617531 4551279 2144162..2144461 1 NC_008611.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; some Mycoplasma proteins contain an N-terminal fusion to an unknown domain; aspartyl/glutamyl-tRNA amidotransferase subunit C 2144461 gatC 4551279 gatC Mycobacterium ulcerans Agy99 aspartyl/glutamyl-tRNA amidotransferase subunit C YP_905863.1 2144162 D 362242 CDS YP_905864.1 118617532 4551280 2144458..2145939 1 NC_008611.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit A 2145939 gatA 4551280 gatA Mycobacterium ulcerans Agy99 aspartyl/glutamyl-tRNA amidotransferase subunit A YP_905864.1 2144458 D 362242 CDS YP_905865.1 118617533 4551281 2146039..2147070 1 NC_008611.1 catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis; 6-phosphofructokinase 2147070 pfkA 4551281 pfkA Mycobacterium ulcerans Agy99 6-phosphofructokinase YP_905865.1 2146039 D 362242 CDS YP_905866.1 118617534 4551282 2147129..2148637 1 NC_008611.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit B 2148637 gatB 4551282 gatB Mycobacterium ulcerans Agy99 aspartyl/glutamyl-tRNA amidotransferase subunit B YP_905866.1 2147129 D 362242 CDS YP_905867.1 118617535 4551284 complement(2149298..2150467) 1 NC_008611.1 membrane protein; lipoprotein LppZ 2150467 lppZ 4551284 lppZ Mycobacterium ulcerans Agy99 lipoprotein LppZ YP_905867.1 2149298 R 362242 CDS YP_905868.1 118617536 4551285 2150650..2151498 1 NC_008611.1 membrane protein; hypothetical protein 2151498 4551285 MUL_1944 Mycobacterium ulcerans Agy99 hypothetical protein YP_905868.1 2150650 D 362242 CDS YP_905869.1 118617537 4551286 complement(2151507..2151866) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; function unknown function (putative membrane protein); low molecular weight protein antigen 6, Cfp6 2151866 cfp6 4551286 cfp6 Mycobacterium ulcerans Agy99 low molecular weight protein antigen 6, Cfp6 YP_905869.1 2151507 R 362242 CDS YP_905870.1 118617538 4551287 2151938..2152069 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2152069 4551287 MUL_1946 Mycobacterium ulcerans Agy99 hypothetical protein YP_905870.1 2151938 D 362242 CDS YP_905871.1 118617539 4551288 2152213..2154069 1 NC_008611.1 acetolactate synthase large subunit; catalyzes the formation of 2-acetolactate from pyruvate; acetolactate synthase 1 catalytic subunit 2154069 ilvB1 4551288 ilvB1 Mycobacterium ulcerans Agy99 acetolactate synthase 1 catalytic subunit YP_905871.1 2152213 D 362242 CDS YP_905872.1 118617540 4551256 2154069..2154578 1 NC_008611.1 with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit; acetolactate synthase 3 regulatory subunit 2154578 ilvH 4551256 ilvH Mycobacterium ulcerans Agy99 acetolactate synthase 3 regulatory subunit YP_905872.1 2154069 D 362242 CDS YP_905873.1 118617541 4551257 2154651..2155652 1 NC_008611.1 catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis; ketol-acid reductoisomerase 2155652 ilvC 4551257 ilvC Mycobacterium ulcerans Agy99 ketol-acid reductoisomerase YP_905873.1 2154651 D 362242 CDS YP_905874.1 118617542 4551258 complement(2155739..2156341) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; hypothetical protein 2156341 4551258 MUL_1950 Mycobacterium ulcerans Agy99 hypothetical protein YP_905874.1 2155739 R 362242 CDS YP_905875.1 118617543 4551260 2157822..2159408 1 NC_008611.1 catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate; D-3-phosphoglycerate dehydrogenase 2159408 serA1 4551260 serA1 Mycobacterium ulcerans Agy99 D-3-phosphoglycerate dehydrogenase YP_905875.1 2157822 D 362242 CDS YP_905876.1 118617544 4551261 2159464..2160483 1 NC_008611.1 catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis; 3-isopropylmalate dehydrogenase 2160483 leuB 4551261 leuB Mycobacterium ulcerans Agy99 3-isopropylmalate dehydrogenase YP_905876.1 2159464 D 362242 CDS YP_905877.1 118617545 4551263 2161955..2162674 1 NC_008611.1 cytoplasmic protein; isomerizes HHDD (2-hydroxy-hept-2,4-diene-1,7- dioate) to ohed (2-oxo-hept-3-ene-1,7-dioate); 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase 2162674 4551263 MUL_1956 Mycobacterium ulcerans Agy99 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase YP_905877.1 2161955 D 362242 CDS YP_905878.1 118617546 4551264 2162734..2164140 1 NC_008611.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation; glutamyl-tRNA synthetase 2164140 gltX 4551264 gltX Mycobacterium ulcerans Agy99 glutamyl-tRNA synthetase YP_905878.1 2162734 D 362242 CDS YP_905879.1 118617547 4551267 complement(2164517..2165038) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2165038 4551267 MUL_1960 Mycobacterium ulcerans Agy99 hypothetical protein YP_905879.1 2164517 R 362242 CDS YP_905880.1 118617548 4551268 2165191..2166156 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2166156 4551268 MUL_1961 Mycobacterium ulcerans Agy99 hypothetical protein YP_905880.1 2165191 D 362242 CDS YP_905881.1 118617549 4551270 2169323..2170369 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 2170369 4551270 MUL_1963 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_905881.1 2169323 D 362242 CDS YP_905882.1 118617550 4551184 complement(2170493..2171827) 1 NC_008611.1 cytoplasmic protein; required for the transposition of the insertion element IS2606.; transposase for IS2606 2171827 4551184 MUL_1964 Mycobacterium ulcerans Agy99 transposase for IS2606 YP_905882.1 2170493 R 362242 CDS YP_905883.1 118617551 4551185 complement(2171917..2172324) 1 NC_008611.1 membrane protein; membrane protein MmpS1 2172324 mmpS1 4551185 mmpS1 Mycobacterium ulcerans Agy99 membrane protein MmpS1 YP_905883.1 2171917 R 362242 CDS YP_905884.1 118617552 4551186 complement(2172564..2173814) 1 NC_008611.1 cytoplasmic protein; could be involved in biotin biosynthesis (at the first step) [catalytic activity: 6-carboxyhexanoyl-CoA + L- alanine = 8-amino-7-oxononanoate + CoA + CO2]; 8-amino-7-oxononanoate synthase BioF2_2 2173814 bioF2_2 4551186 bioF2_2 Mycobacterium ulcerans Agy99 8-amino-7-oxononanoate synthase BioF2_2 YP_905884.1 2172564 R 362242 CDS YP_905885.1 118617553 4551187 complement(2174358..2175059) 1 NC_008611.1 cytoplasmic protein; involved in transcriptional mechanism.; transcriptional regulatory protein 2175059 4551187 MUL_1967 Mycobacterium ulcerans Agy99 transcriptional regulatory protein YP_905885.1 2174358 R 362242 CDS YP_905886.1 118617554 4551188 2175142..2176563 1 NC_008611.1 dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; isopropylmalate isomerase large subunit 2176563 leuC 4551188 leuC Mycobacterium ulcerans Agy99 isopropylmalate isomerase large subunit YP_905886.1 2175142 D 362242 CDS YP_905887.1 118617555 4551189 2176588..2177184 1 NC_008611.1 catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D; isopropylmalate isomerase small subunit 2177184 leuD 4551189 leuD Mycobacterium ulcerans Agy99 isopropylmalate isomerase small subunit YP_905887.1 2176588 D 362242 CDS YP_905888.1 118617556 4551190 2177409..2178098 1 NC_008611.1 Detected in the cytoplasmic fraction by LC-MS/MS. Also detected in the extracellular matrix and the membrane fraction by proteomics.; cytoplasmic protein; this protein belongs to the histone like family of prokaryotic DNA-binding proteins which are capable of wrapping DNA to stabilize it, and prevent its denaturation under extreme environmental conditions.; DNA-binding protein HU HupB-like protein 2178098 hupB 4551190 hupB Mycobacterium ulcerans Agy99 DNA-binding protein HU HupB-like protein YP_905888.1 2177409 D 362242 CDS YP_905889.1 118617557 4551191 complement(2178160..2179098) 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; function unknown, hydrolytic enzyme. possibly involved in removal of damaged nucleotide.; hydrolase MutT1 2179098 mutT1 4551191 mutT1 Mycobacterium ulcerans Agy99 hydrolase MutT1 YP_905889.1 2178160 R 362242 CDS YP_905890.1 118617558 4551192 complement(2179178..2181394) 1 NC_008611.1 catalyzes the reversible transfer of the terminal phosphate of ATP to form a long chain polyphosphate; polyphosphate kinase 2181394 ppk 4551192 ppk Mycobacterium ulcerans Agy99 polyphosphate kinase YP_905890.1 2179178 R 362242 CDS YP_905891.1 118617559 4551193 complement(2181473..2182126) 1 NC_008611.1 membrane protein; hypothetical protein 2182126 4551193 MUL_1973 Mycobacterium ulcerans Agy99 hypothetical protein YP_905891.1 2181473 R 362242 CDS YP_905892.1 118617560 4551194 2182318..2183325 1 NC_008611.1 catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase 2183325 gpsA 4551194 gpsA Mycobacterium ulcerans Agy99 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase YP_905892.1 2182318 D 362242 CDS YP_905893.1 118617561 4551195 2183417..2184538 1 NC_008611.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanyl-alanine synthetase A 2184538 ddl 4551195 ddl Mycobacterium ulcerans Agy99 D-alanyl-alanine synthetase A YP_905893.1 2183417 D 362242 CDS YP_905894.1 118617562 4551196 complement(2184535..2185119) 1 NC_008611.1 membrane protein; hypothetical protein 2185119 4551196 MUL_1977 Mycobacterium ulcerans Agy99 hypothetical protein YP_905894.1 2184535 R 362242 CDS YP_905895.1 118617563 4551197 2185327..2186292 1 NC_008611.1 catalyzes the formation of thiamine diphosphate from thiamine phosphate ant ATP; thiamine monophosphate kinase 2186292 thiL 4551197 thiL Mycobacterium ulcerans Agy99 thiamine monophosphate kinase YP_905895.1 2185327 D 362242 CDS YP_905896.1 118617564 4551198 2186318..2186608 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2186608 4551198 MUL_1979 Mycobacterium ulcerans Agy99 hypothetical protein YP_905896.1 2186318 D 362242 CDS YP_905897.1 118617565 4551199 2186605..2187288 1 NC_008611.1 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; uracil-DNA glycosylase 2187288 ung 4551199 ung Mycobacterium ulcerans Agy99 uracil-DNA glycosylase YP_905897.1 2186605 D 362242 CDS YP_905898.1 118617566 4551201 2188503..2188925 1 NC_008611.1 cytoplasmic protein; function unknown; probably involved in cellular metabolism.; nitroreductase 2188925 4551201 MUL_1982 Mycobacterium ulcerans Agy99 nitroreductase YP_905898.1 2188503 D 362242 CDS YP_905899.1 118617567 4551202 complement(2189081..2189275) 1 NC_008611.1 required for 70S ribosome assembly; 50S ribosomal protein L28 2189275 rpmB 4551202 rpmB Mycobacterium ulcerans Agy99 50S ribosomal protein L28 YP_905899.1 2189081 R 362242 CDS YP_905900.1 118617568 4551166 2191253..2193484 1 NC_008611.1 catalyzes branch migration in Holliday junction intermediates; ATP-dependent DNA helicase RecG 2193484 recG 4551166 recG Mycobacterium ulcerans Agy99 ATP-dependent DNA helicase RecG YP_905900.1 2191253 D 362242 CDS YP_905901.1 118617569 4551168 complement(2194207..2195055) 1 NC_008611.1 Detected in the cytoplamic fraction by LC-MS/MS.; cytoplasmic protein; function unknown, probably involved in cellular metabolism.; oxidoreductase 2195055 4551168 MUL_1987 Mycobacterium ulcerans Agy99 oxidoreductase YP_905901.1 2194207 R 362242 CDS YP_905902.1 118617570 4551169 complement(2195242..2195577) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2195577 4551169 MUL_1988 Mycobacterium ulcerans Agy99 hypothetical protein YP_905902.1 2195242 R 362242 CDS YP_905903.1 118617571 4551170 2195623..2196741 1 NC_008611.1 cytoplasmic protein; function unknown, lipolytic enzyme involved in cellular metabolism.; lipase/esterase LipN 2196741 lipN 4551170 lipN Mycobacterium ulcerans Agy99 lipase/esterase LipN YP_905903.1 2195623 D 362242 CDS YP_905904.1 118617572 4551171 2196928..2197695 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; hypothetical protein 2197695 4551171 MUL_1990 Mycobacterium ulcerans Agy99 hypothetical protein YP_905904.1 2196928 D 362242 CDS YP_905905.1 118617573 4551172 2197701..2198339 1 NC_008611.1 membrane protein; integral membrane protein 2198339 4551172 MUL_1991 Mycobacterium ulcerans Agy99 integral membrane protein YP_905905.1 2197701 D 362242 CDS YP_905906.1 118617574 4551173 2198382..2201777 1 NC_008611.1 biotin-containing enzyme that catalyzes a two step carboxylation of pyruvate to oxaloacetate; pyruvate carboxylase 2201777 pca 4551173 pca Mycobacterium ulcerans Agy99 pyruvate carboxylase YP_905906.1 2198382 D 362242 CDS YP_905907.1 118617575 4551175 2202402..2202875 1 NC_008611.1 Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA; phosphopantetheine adenylyltransferase 2202875 coaD 4551175 coaD Mycobacterium ulcerans Agy99 phosphopantetheine adenylyltransferase YP_905907.1 2202402 D 362242 CDS YP_905908.1 118617576 4551176 complement(2202949..2203131) 1 NC_008611.1 secreted protein; hypothetical protein 2203131 4551176 MUL_1995 Mycobacterium ulcerans Agy99 hypothetical protein YP_905908.1 2202949 R 362242 CDS YP_905909.1 118617577 4551178 complement(2204219..2205400) 1 NC_008611.1 membrane protein; hypothetical protein 2205400 4551178 MUL_1997 Mycobacterium ulcerans Agy99 hypothetical protein YP_905909.1 2204219 R 362242 CDS YP_905910.1 118617578 4551180 2207326..2208123 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2208123 4551180 MUL_1999 Mycobacterium ulcerans Agy99 hypothetical protein YP_905910.1 2207326 D 362242 CDS YP_905911.1 118617579 4551181 complement(2208174..2209430) 1 NC_008611.1 membrane protein; hypothetical protein 2209430 4551181 MUL_2000 Mycobacterium ulcerans Agy99 hypothetical protein YP_905911.1 2208174 R 362242 CDS YP_905912.1 118617580 4551183 2211634..2213496 1 NC_008611.1 activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 2213496 fadD29 4551183 fadD29 Mycobacterium ulcerans Agy99 acyl-CoA synthetase YP_905912.1 2211634 D 362242 CDS YP_905913.1 118617581 4551127 2213501..2214139 1 NC_008611.1 cytoplasmic protein; responsible for the direct conversion of chorismate to p-hydroxybenzoate, the substrate used in the production of glycosylated p-hydroxybenzoic acid methyl esters and structurally related phenolphthiocerol glycolipids. in M. tuberculosis, this is the sole enzymatic source of p- hydroxybenzoic acid.; chorismate pyruvate-lyase 2214139 4551127 MUL_2003 Mycobacterium ulcerans Agy99 chorismate pyruvate-lyase YP_905913.1 2213501 D 362242 CDS YP_905914.1 118617582 4551128 2214258..2216366 1 NC_008611.1 activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 2216366 fadD22 4551128 fadD22 Mycobacterium ulcerans Agy99 acyl-CoA synthetase YP_905914.1 2214258 D 362242 CDS YP_905915.1 118617583 4551129 2216383..2222697 1 NC_008611.1 Also detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; polyketide synthase required for the elongation of p-HBAD derivatives to form p-hydroxybenzoate derivatives which are in turn converted to phenolphthiocerols by the ppsA-E locus. this is a key step in the production of phenolic glycolipids.; polyketide synthase Pks15/1 2222697 pks15/1 4551129 pks15/1 Mycobacterium ulcerans Agy99 polyketide synthase Pks15/1 YP_905915.1 2216383 D 362242 CDS YP_905916.1 118617584 4551130 2223112..2223801 1 NC_008611.1 Also detected in the membrane fraction by proteomics.; secreted protein; lipoprotein LppX 2223801 lppX 4551130 lppX Mycobacterium ulcerans Agy99 lipoprotein LppX YP_905916.1 2223112 D 362242 CDS YP_905917.1 118617585 4551131 complement(2223841..2226591) 1 NC_008611.1 secreted protein; involved in translocation of phthiocerol dimycocerosate (DIM) in the cell wall.; transmembrane transport protein MmpL7 2226591 mmpL7 4551131 mmpL7 Mycobacterium ulcerans Agy99 transmembrane transport protein MmpL7 YP_905917.1 2223841 R 362242 CDS YP_905918.1 118617586 4551132 complement(2226593..2228335) 1 NC_008611.1 activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 2228335 fadD28 4551132 fadD28 Mycobacterium ulcerans Agy99 acyl-CoA synthetase YP_905918.1 2226593 R 362242 CDS YP_905919.1 118617587 4551133 2228774..2229550 1 NC_008611.1 cytoplasmic protein; function unknown but orthologue in M. tuberculosis H37Rv has been shown to catalyze the transfer of a methyl group onto the lipid moiety of phthiotriol dimycocerosates to form DIM.; methyltransferase 2229550 4551133 MUL_2009 Mycobacterium ulcerans Agy99 methyltransferase YP_905919.1 2228774 D 362242 CDS YP_905920.1 118617588 4551134 2230171..2236470 1 NC_008611.1 At least three isoforms were detected in the cytoplasmic extract. Also detected in the membrane fraction by proteomics.; membrane protein; catalyzes the elongation of N-fatty acyl-CoA with methylamalonyl-CoA (not malonyl-CoA) as the elongating agent to form mycocerosyl lipids.; multifunctional mycocerosic acid synthase membrane-associated Mas 2236470 mas 4551134 mas Mycobacterium ulcerans Agy99 multifunctional mycocerosic acid synthase membrane-associated Mas YP_905920.1 2230171 D 362242 CDS YP_905921.1 118617589 4551135 complement(2236674..2237918) 1 NC_008611.1 required for PDIM synthesis; phthiocerol and phthiodiolone dimycocerosate esters are scaffolds used for virulence-enhancing lipids; proposed to catalyze diesterification of phthiocerol and phthiodolone with mycocerosate; functions in polyketide synthesis; acyltransferase PapA5 2237918 papA5 4551135 papA5 Mycobacterium ulcerans Agy99 acyltransferase PapA5 YP_905921.1 2236674 R 362242 CDS YP_905922.1 118617590 4551136 complement(2237952..2238782) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; probably involved in active transport of phthiocerol dimycocerosate (DIM) across the membrane (export) DrrA, DrrB and DrrC may act jointly to confer daunorubicin and doxorubicin resistance by an export mechanism. probably responsible for the translocation of the substrate across the membrane and localization of dim into the cell wall.; daunorubicin-DIM-transport integral membrane protein ABC transporter DrrC 2238782 drrC 4551136 drrC Mycobacterium ulcerans Agy99 daunorubicin-DIM-transport integral membrane protein ABC transporter DrrC YP_905922.1 2237952 R 362242 CDS YP_905923.1 118617591 4551137 complement(2238779..2239648) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; probably involved in active transport of phthiocerol dimycocerosate (DIM) across the membrane (export) DrrA, DrrB and DrrC may act jointly to confer daunorubicin and doxorubicin resistance by an export mechanism. probably responsible for the translocation of the substrate across the membrane and localization of DIM into the cell wall.; daunorubicin-DIM-transport integral membrane protein ABC transporter DrrB 2239648 drrB 4551137 drrB Mycobacterium ulcerans Agy99 daunorubicin-DIM-transport integral membrane protein ABC transporter DrrB YP_905923.1 2238779 R 362242 CDS YP_905924.1 118617592 4551138 complement(2239645..2240640) 1 NC_008611.1 Detected in the membrane fraction by proteomics; membrane protein; probably involved in active transport of antibiotic and phthiocerol dimycocerosate (DIM) across the membrane (export) DrrA, DrrB and DrrC may act jointly to confer daunorubicin and doxorubicin resistance by an export mechanism. responsible for energy coupling to the transport system.; daunorubicin-DIM-transport ATP-binding protein ABC transporter DrrA 2240640 drrA 4551138 drrA Mycobacterium ulcerans Agy99 daunorubicin-DIM-transport ATP-binding protein ABC transporter DrrA YP_905924.1 2239645 R 362242 CDS YP_905925.1 118617593 4551139 complement(2240651..2245096) 1 NC_008611.1 Three isoforms of the protein were detected in the cytoplasm by proteomics. Also detected in the membrane fraction by proteomics.; cytoplasmic protein; involved in phenolpthiocerol and phthiocerol dimycocerosate (DIM) biosynthesis: extension with Malony CoA (partial reduction, decarboxylation); phenolpthiocerol synthesis type-I polyketide synthase PpsE 2245096 ppsE 4551139 ppsE Mycobacterium ulcerans Agy99 phenolpthiocerol synthesis type-I polyketide synthase PpsE YP_905925.1 2240651 R 362242 CDS YP_905926.1 118617594 4551140 complement(2245102..2250522) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; involved in phenolpthiocerol and phthiocerol dimycocerosate (DIM) biosynthesis: extension with methylmalony CoA (partial reduction); phenolpthiocerol synthesis type-I polyketide synthase PpsD 2250522 ppsD 4551140 ppsD Mycobacterium ulcerans Agy99 phenolpthiocerol synthesis type-I polyketide synthase PpsD YP_905926.1 2245102 R 362242 CDS YP_905927.1 118617595 4551141 complement(2250522..2257127) 1 NC_008611.1 Detected in the cytoplasmic fraction by proteomics.; cytoplasmic protein; involved in phenolpthiocerol and phthiocerol dimycocerosate (DIM) biosynthesis: extension with Malony CoA (complete reduction); phenolpthiocerol synthesis type-I polyketide synthase PpsC 2257127 ppsC 4551141 ppsC Mycobacterium ulcerans Agy99 phenolpthiocerol synthesis type-I polyketide synthase PpsC YP_905927.1 2250522 R 362242 CDS YP_905928.1 118617596 4551142 complement(2257127..2261671) 1 NC_008611.1 Detected in the membrane fraction by proteomics (2D- LC-MS/MS); membrane protein; involved in phenolpthiocerol and phthiocerol dimycocerosate (DIM) biosynthesis: extension with Malony CoA (partial reduction); phenolpthiocerol synthesis type-I polyketide synthase PpsB 2261671 ppsB 4551142 ppsB Mycobacterium ulcerans Agy99 phenolpthiocerol synthesis type-I polyketide synthase PpsB YP_905928.1 2257127 R 362242 CDS YP_905929.1 118617597 4551143 complement(2261701..2266509) 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS. Also detected in the membrane fraction by proteomics (LC-MS/MS); cytoplasmic protein; involved in phenolpthiocerol and phthiocerol dimycocerosate (DIM) biosynthesis: extension of C18 with Malony CoA (partial reduction); phenolpthiocerol synthesis type-I polyketide synthase PpsA 2266509 ppsA 4551143 ppsA Mycobacterium ulcerans Agy99 phenolpthiocerol synthesis type-I polyketide synthase PpsA YP_905929.1 2261701 R 362242 CDS YP_905930.1 118617598 4551144 complement(2266506..2268260) 1 NC_008611.1 activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 2268260 fadD26 4551144 fadD26 Mycobacterium ulcerans Agy99 acyl-CoA synthetase YP_905930.1 2266506 R 362242 CDS YP_905931.1 118617599 4551074 complement(2268911..2269228) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; C-term transposase for IS2404 2269228 4551074 MUL_2023 Mycobacterium ulcerans Agy99 C-term transposase for IS2404 YP_905931.1 2268911 R 362242 CDS YP_905932.1 118617600 4551075 complement(2269253..2269957) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; N-term transposase for IS2404 2269957 4551075 MUL_2024 Mycobacterium ulcerans Agy99 N-term transposase for IS2404 YP_905932.1 2269253 R 362242 CDS YP_905933.1 118617601 4551076 complement(2270352..2271101) 1 NC_008611.1 cytoplasmic protein; function unknown however in M. tuberculosis H37Rv TesA interacts with the PpsE protein. PpsE is part of the phenolphthiocerol synthase PKS cluster.; thioesterase TesA 2271101 tesA 4551076 tesA Mycobacterium ulcerans Agy99 thioesterase TesA YP_905933.1 2270352 R 362242 CDS YP_905934.1 118617602 4551077 complement(2271191..2271508) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; C-term transposase for IS2404 2271508 4551077 MUL_2026 Mycobacterium ulcerans Agy99 C-term transposase for IS2404 YP_905934.1 2271191 R 362242 CDS YP_905935.1 118617603 4551078 complement(2271533..2272237) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; N-term transposase for IS2404 2272237 4551078 MUL_2027 Mycobacterium ulcerans Agy99 N-term transposase for IS2404 YP_905935.1 2271533 R 362242 CDS YP_905936.1 118617604 4551079 2272726..2273469 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; function unknown, possibly involved in cell division and chromosome partitioning.; hypothetical protein 2273469 4551079 MUL_2028 Mycobacterium ulcerans Agy99 hypothetical protein YP_905936.1 2272726 D 362242 CDS YP_905937.1 118617605 4551080 2273544..2274137 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2274137 4551080 MUL_2029 Mycobacterium ulcerans Agy99 hypothetical protein YP_905937.1 2273544 D 362242 CDS YP_905938.1 118617606 4551081 2274134..2274865 1 NC_008611.1 cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity; ribonuclease III 2274865 rnc 4551081 rnc Mycobacterium ulcerans Agy99 ribonuclease III YP_905938.1 2274134 D 362242 CDS YP_905939.1 118617607 4551082 2274866..2275744 1 NC_008611.1 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases; formamidopyrimidine-DNA glycosylase 2275744 fpg 4551082 fpg Mycobacterium ulcerans Agy99 formamidopyrimidine-DNA glycosylase YP_905939.1 2274866 D 362242 CDS YP_905940.1 118617608 4551083 2275836..2276528 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; function unknown. contains N-term OsmC-like protein domain and C-term AcyP, acylphosphatases domain.; hypothetical protein 2276528 4551083 MUL_2032 Mycobacterium ulcerans Agy99 hypothetical protein YP_905940.1 2275836 D 362242 CDS YP_905941.1 118617609 4551084 2276627..2280229 1 NC_008611.1 membrane protein; plays an important role in chromosome structure and partitioning. essential for chromosome partition.; chromosome partition protein Smc 2280229 smc 4551084 smc Mycobacterium ulcerans Agy99 chromosome partition protein Smc YP_905941.1 2276627 D 362242 CDS YP_905942.1 118617610 4551085 2280289..2281656 1 NC_008611.1 membrane protein; probably involved in the reception and insertion of a subset of proteins at the membrane: possibly membrane receptor for Ffh.; cell division protein FtsY 2281656 ftsY 4551085 ftsY Mycobacterium ulcerans Agy99 cell division protein FtsY YP_905942.1 2280289 D 362242 CDS YP_905943.1 118617611 4551087 2283229..2283567 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; in nitrogen-limiting conditions, when the ratio of Gln to 2-ketoglutarate decreases, P-II is uridylylated to P-II-UMP by GlnD. P-II-UMP allows the deadenylylation of glutamine synthetase (gs), thus activating the enzyme. converserly, in nitrogen excess P-II is deuridylated and promotes the adenylation of gs. P-II indirectly controls the transcription of the gs gene. P-II prevents NR-II catalyzed conversion of NR-I to NR-I-phosphate, the transcriptional activator of GlnA. when P-II is uridylylated to P-II-UMP, these events are reversed.; nitrogen regulatory protein P-II GlnB 2283567 glnB 4551087 glnB Mycobacterium ulcerans Agy99 nitrogen regulatory protein P-II GlnB YP_905943.1 2283229 D 362242 CDS YP_905944.1 118617612 4551089 complement(2286125..2287861) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2287861 4551089 MUL_2038 Mycobacterium ulcerans Agy99 hypothetical protein YP_905944.1 2286125 R 362242 CDS YP_905945.1 118617613 4551090 complement(2288077..2288292) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2288292 4551090 MUL_2039 Mycobacterium ulcerans Agy99 hypothetical protein YP_905945.1 2288077 R 362242 CDS YP_905946.1 118617614 4551091 2288431..2290002 1 NC_008611.1 Also detected in the cytoplasmic fraction by 2D-LC- MS/MS; cytoplasmic protein; necessary for efficient export of extra-cytoplasmic proteins. binds to the signal sequence when it emerges from the ribosomes.; signal recognition particle protein Ffh 2290002 ffh 4551091 ffh Mycobacterium ulcerans Agy99 signal recognition particle protein Ffh YP_905946.1 2288431 D 362242 CDS YP_905947.1 118617615 4551055 2290009..2291100 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2291100 4551055 MUL_2041 Mycobacterium ulcerans Agy99 hypothetical protein YP_905947.1 2290009 D 362242 CDS YP_905948.1 118617616 4551056 2291149..2292954 1 NC_008611.1 membrane protein; involved in signal transduction (via phosphorylation) thought to be involved in cell division/differentiation [catalytic activity: ATP + a protein = ADP + a phosphoprotein]; transmembrane serine/threonine-protein kinase I PknI 2292954 pknI 4551056 pknI Mycobacterium ulcerans Agy99 transmembrane serine/threonine-protein kinase I PknI YP_905948.1 2291149 D 362242 CDS YP_905949.1 118617617 4551057 2293060..2294853 1 NC_008611.1 cytoplasmic protein; hydrolizes a specific D-amino acid.; D-amino acid aminohydrolase 2294853 4551057 MUL_2043 Mycobacterium ulcerans Agy99 D-amino acid aminohydrolase YP_905949.1 2293060 D 362242 CDS YP_905950.1 118617618 4551058 2294855..2295457 1 NC_008611.1 cytoplasmic protein; thought to be involved in transcriptional mechanism.; TetR family transcriptional regulator 2295457 4551058 MUL_2044 Mycobacterium ulcerans Agy99 TetR family transcriptional regulator YP_905950.1 2294855 D 362242 CDS YP_905951.1 118617619 4551059 complement(2295477..2296349) 1 NC_008611.1 secreted protein; involved in peptidoglycan synthesis (at final stages) hydrolyzes the bound D-alanyl-D-alanine [catalytic activity: D-alanyl-D-alanine + H(2)O = 2 D- alanine]; D-alanyl-D-alanine carboxypeptidase DacB 2296349 dacB 4551059 dacB Mycobacterium ulcerans Agy99 D-alanyl-D-alanine carboxypeptidase DacB YP_905951.1 2295477 R 362242 CDS YP_905952.1 118617620 4551060 2296406..2296840 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2296840 4551060 MUL_2046 Mycobacterium ulcerans Agy99 hypothetical protein YP_905952.1 2296406 D 362242 CDS YP_905953.1 118617621 4551061 2297046..2297531 1 NC_008611.1 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity; 30S ribosomal protein S16 2297531 rpsP 4551061 rpsP Mycobacterium ulcerans Agy99 30S ribosomal protein S16 YP_905953.1 2297046 D 362242 CDS YP_905954.1 118617622 4551062 2297540..2297782 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; hypothetical protein 2297782 4551062 MUL_2048 Mycobacterium ulcerans Agy99 hypothetical protein YP_905954.1 2297540 D 362242 CDS YP_905955.1 118617623 4551063 2297807..2298331 1 NC_008611.1 Essential for efficient processing of 16S rRNA; 16S rRNA-processing protein RimM 2298331 rimM 4551063 rimM Mycobacterium ulcerans Agy99 16S rRNA-processing protein RimM YP_905955.1 2297807 D 362242 CDS YP_905956.1 118617624 4551064 2298340..2299032 1 NC_008611.1 methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA; tRNA (guanine-N(1)-)-methyltransferase 2299032 trmD 4551064 trmD Mycobacterium ulcerans Agy99 tRNA (guanine-N(1)-)-methyltransferase YP_905956.1 2298340 D 362242 CDS YP_905957.1 118617625 4551065 complement(2299144..2300103) 1 NC_008611.1 secreted protein; alanine rich lipoprotein LppW 2300103 lppW 4551065 lppW Mycobacterium ulcerans Agy99 alanine rich lipoprotein LppW YP_905957.1 2299144 R 362242 CDS YP_905958.1 118617626 4551066 2300461..2300802 1 NC_008611.1 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site; 50S ribosomal protein L19 2300802 rplS 4551066 rplS Mycobacterium ulcerans Agy99 50S ribosomal protein L19 YP_905958.1 2300461 D 362242 CDS YP_905959.1 118617627 4551067 2300914..2301777 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; cleavage of N-terminal leader sequences from secreted protein precursors.; signal peptidase I LepB 2301777 lepB 4551067 lepB Mycobacterium ulcerans Agy99 signal peptidase I LepB YP_905959.1 2300914 D 362242 CDS YP_905960.1 118617628 4551068 2301780..2302499 1 NC_008611.1 RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids; ribonuclease HII 2302499 rnhB 4551068 rnhB Mycobacterium ulcerans Agy99 ribonuclease HII YP_905960.1 2301780 D 362242 CDS YP_905961.1 118617629 4551069 2302619..2302924 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2302924 4551069 MUL_2055 Mycobacterium ulcerans Agy99 hypothetical protein YP_905961.1 2302619 D 362242 CDS YP_905962.1 118617630 4551071 complement(2303798..2305156) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2305156 4551071 MUL_2057 Mycobacterium ulcerans Agy99 hypothetical protein YP_905962.1 2303798 R 362242 CDS YP_905963.1 118617631 4551072 2305274..2306254 1 NC_008611.1 membrane protein; function unknown, possibly involved in galactose metabolism.; hypothetical protein 2306254 4551072 MUL_2058 Mycobacterium ulcerans Agy99 hypothetical protein YP_905963.1 2305274 D 362242 CDS YP_905964.1 118617632 4551073 2306389..2307210 1 NC_008611.1 involved in the production or activity of formate dehydrogenase-H which is active when nitrate is not present during anaerobic growth; formate dehydrogenase accessory protein 2307210 fdhD 4551073 fdhD Mycobacterium ulcerans Agy99 formate dehydrogenase accessory protein YP_905964.1 2306389 D 362242 CDS YP_905965.1 118617633 4551019 2307327..2307695 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2307695 4551019 MUL_2060 Mycobacterium ulcerans Agy99 hypothetical protein YP_905965.1 2307327 D 362242 CDS YP_905966.1 118617634 4551021 2309203..2310378 1 NC_008611.1 membrane protein; hypothetical protein 2310378 4551021 MUL_2062 Mycobacterium ulcerans Agy99 hypothetical protein YP_905966.1 2309203 D 362242 CDS YP_905967.1 118617635 4551022 2310411..2311259 1 NC_008611.1 Also detected in the extracellular matrix by proteomics.; cytoplasmic protein; thought to be involved in intracellular removal of iron from iron-mycobactin complex. mycobactin is an iron- chelating compound involved in the transport of iron from the bacterial environment into the cell cytoplasm.; mycobactin utilization protein ViuB 2311259 viuB 4551022 viuB Mycobacterium ulcerans Agy99 mycobactin utilization protein ViuB YP_905967.1 2310411 D 362242 CDS YP_905968.1 118617636 4551024 2312473..2313381 1 NC_008611.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerC 2313381 xerC 4551024 xerC Mycobacterium ulcerans Agy99 site-specific tyrosine recombinase XerC YP_905968.1 2312473 D 362242 CDS YP_905969.1 118617637 4551026 2314218..2315033 1 NC_008611.1 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit; 30S ribosomal protein S2 2315033 rpsB 4551026 rpsB Mycobacterium ulcerans Agy99 30S ribosomal protein S2 YP_905969.1 2314218 D 362242 CDS YP_905970.1 118617638 4551027 2315035..2315850 1 NC_008611.1 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu; elongation factor Ts 2315850 tsf 4551027 tsf Mycobacterium ulcerans Agy99 elongation factor Ts YP_905970.1 2315035 D 362242 CDS YP_905971.1 118617639 4551028 2315871..2317289 1 NC_008611.1 catalyzes the hydrolysis of a monocarboxylic acid amid to form a monocarboxylate and ammonia; amidase 2317289 amiC 4551028 amiC Mycobacterium ulcerans Agy99 amidase YP_905971.1 2315871 D 362242 CDS YP_905972.1 118617640 4551029 complement(2317305..2317733) 1 NC_008611.1 membrane protein; involved in transcriptional mechanism.; transcriptional regulatory protein 2317733 4551029 MUL_2070 Mycobacterium ulcerans Agy99 transcriptional regulatory protein YP_905972.1 2317305 R 362242 CDS YP_905973.1 118617641 4551030 2318013..2318417 1 NC_008611.1 membrane protein; hypothetical protein 2318417 4551030 MUL_2071 Mycobacterium ulcerans Agy99 hypothetical protein YP_905973.1 2318013 D 362242 CDS YP_905974.1 118617642 4551031 2318705..2319565 1 NC_008611.1 membrane protein; hypothetical protein 2319565 4551031 MUL_2072 Mycobacterium ulcerans Agy99 hypothetical protein YP_905974.1 2318705 D 362242 CDS YP_905975.1 118617643 4551032 complement(2319566..2320306) 1 NC_008611.1 cytoplasmic protein; involved in transcriptional mechanism; transcriptional regulatory protein 2320306 4551032 MUL_2073 Mycobacterium ulcerans Agy99 transcriptional regulatory protein YP_905975.1 2319566 R 362242 CDS YP_905976.1 118617644 4551033 2320486..2321556 1 NC_008611.1 Also detected in the membrane fraction by proteomics (2D-LC-MS/MS); cytoplasmic protein; uridine monophosphate kinase [catalytic activity: ATP + ump = ADP + UDP]; uridylate kinase PyrH 2321556 pyrH 4551033 pyrH Mycobacterium ulcerans Agy99 uridylate kinase PyrH YP_905976.1 2320486 D 362242 CDS YP_905977.1 118617645 4551034 2321621..2322178 1 NC_008611.1 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs; ribosome recycling factor 2322178 frr 4551034 frr Mycobacterium ulcerans Agy99 ribosome recycling factor YP_905977.1 2321621 D 362242 CDS YP_905978.1 118617646 4551035 2322211..2323125 1 NC_008611.1 membrane protein; involved in the phospholipid biosynthesis [catalytic activity: CTP + phosphatidate = pyrophosphate + CDP-diacylglycerol]; integral membrane phosphatidate cytidylyltransferase CdsA 2323125 cdsA 4551035 cdsA Mycobacterium ulcerans Agy99 integral membrane phosphatidate cytidylyltransferase CdsA YP_905978.1 2322211 D 362242 CDS YP_905979.1 118617647 4551001 2324231..2325325 1 NC_008611.1 23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance; ribosomal RNA large subunit methyltransferase N 2325325 4551001 MUL_2078 Mycobacterium ulcerans Agy99 ribosomal RNA large subunit methyltransferase N YP_905979.1 2324231 D 362242 CDS YP_905980.1 118617648 4551002 2325505..2325978 1 NC_008611.1 secreted protein; not really known. despite a weak homology to thioredoxin this cannot serve as a substrate for thioredoxin reductase. furthermore it has no disulfide reducing activity.; soluble secreted antigen Mpt53 precursor 2325978 mpt53 4551002 mpt53 Mycobacterium ulcerans Agy99 soluble secreted antigen Mpt53 precursor YP_905980.1 2325505 D 362242 CDS YP_905981.1 118617649 4551003 2325992..2326864 1 NC_008611.1 membrane protein; function unknown, possibly involved in transport of mercury across the membrane.; integral membrane protein 2326864 4551003 MUL_2080 Mycobacterium ulcerans Agy99 integral membrane protein YP_905981.1 2325992 D 362242 CDS YP_905982.1 118617650 4551004 2326880..2327302 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2327302 4551004 MUL_2081 Mycobacterium ulcerans Agy99 hypothetical protein YP_905982.1 2326880 D 362242 CDS YP_905983.1 118617651 4551006 2327800..2328846 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 2328846 4551006 MUL_2083 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_905983.1 2327800 D 362242 CDS YP_905984.1 118617652 4551007 complement(2329370..2331121) 1 NC_008611.1 membrane protein; may be involved in cytochrome-C biogenesis.; integral membrane C-type cytochrome biogenesis protein DipZ 2331121 dipZ 4551007 dipZ Mycobacterium ulcerans Agy99 integral membrane C-type cytochrome biogenesis protein DipZ YP_905984.1 2329370 R 362242 CDS YP_905985.1 118617653 4551008 2331209..2332417 1 NC_008611.1 catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate; 1-deoxy-D-xylulose 5-phosphate reductoisomerase 2332417 dxr 4551008 dxr Mycobacterium ulcerans Agy99 1-deoxy-D-xylulose 5-phosphate reductoisomerase YP_905985.1 2331209 D 362242 CDS YP_905986.1 118617654 4551009 2332437..2333651 1 NC_008611.1 membrane protein; transmembrane protein 2333651 4551009 MUL_2086 Mycobacterium ulcerans Agy99 transmembrane protein YP_905986.1 2332437 D 362242 CDS YP_905987.1 118617655 4551010 2333746..2334837 1 NC_008611.1 catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase 2334837 ispG 4551010 ispG Mycobacterium ulcerans Agy99 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase YP_905987.1 2333746 D 362242 CDS YP_905988.1 118617656 4551011 2334889..2335743 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2335743 4551011 MUL_2088 Mycobacterium ulcerans Agy99 hypothetical protein YP_905988.1 2334889 D 362242 CDS YP_905989.1 118617657 4551012 2335854..2337668 1 NC_008611.1 secreted protein; function unknown, possibly involved in cell wall biosynthesis.; penicillin-binding lipoprotein 2337668 4551012 MUL_2089 Mycobacterium ulcerans Agy99 penicillin-binding lipoprotein YP_905989.1 2335854 D 362242 CDS YP_905990.1 118617658 4551013 2337780..2338364 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2338364 4551013 MUL_2090 Mycobacterium ulcerans Agy99 hypothetical protein YP_905990.1 2337780 D 362242 CDS YP_905991.1 118617659 4551014 2338511..2339326 1 NC_008611.1 cytoplasmic protein; removes the amino-terminal methionine from nascent proteins [catalytic activity: L-methionylpeptide + H(2)O = L-methionine + peptide]; methionine aminopeptidase MapB 2339326 mapB 4551014 mapB Mycobacterium ulcerans Agy99 methionine aminopeptidase MapB YP_905991.1 2338511 D 362242 CDS YP_905992.1 118617660 4551015 2339533..2340084 1 NC_008611.1 membrane protein; hypothetical protein 2340084 4551015 MUL_2092 Mycobacterium ulcerans Agy99 hypothetical protein YP_905992.1 2339533 D 362242 CDS YP_905993.1 118617661 4551016 2340217..2340954 1 NC_008611.1 cytoplasmic protein; function unknown, probably involved in cellular metabolism.; amidotransferase 2340954 4551016 MUL_2093 Mycobacterium ulcerans Agy99 amidotransferase YP_905993.1 2340217 D 362242 CDS YP_905994.1 118617662 4551017 complement(2341023..2341991) 1 NC_008611.1 membrane protein; PPE family protein 2341991 4551017 MUL_2094 Mycobacterium ulcerans Agy99 PPE family protein YP_905994.1 2341023 R 362242 CDS YP_905995.1 118617663 4551018 complement(2342273..2342821) 1 NC_008611.1 membrane protein; hypothetical protein 2342821 4551018 MUL_2095 Mycobacterium ulcerans Agy99 hypothetical protein YP_905995.1 2342273 R 362242 CDS YP_905996.1 118617664 4550982 complement(2342876..2344042) 1 NC_008611.1 membrane protein; PPE family protein 2344042 4550982 MUL_2096 Mycobacterium ulcerans Agy99 PPE family protein YP_905996.1 2342876 R 362242 CDS YP_905997.1 118617665 4550983 complement(2344282..2344713) 1 NC_008611.1 membrane protein; hypothetical protein 2344713 4550983 MUL_2097 Mycobacterium ulcerans Agy99 hypothetical protein YP_905997.1 2344282 R 362242 CDS YP_905998.1 118617666 4550987 2348906..2349340 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2349340 4550987 MUL_2101 Mycobacterium ulcerans Agy99 hypothetical protein YP_905998.1 2348906 D 362242 CDS YP_905999.1 118617667 4550990 2352209..2352322 1 NC_008611.1 hypothetical protein 2352322 4550990 MUL_2106 Mycobacterium ulcerans Agy99 hypothetical protein YP_905999.1 2352209 D 362242 CDS YP_906000.1 118617668 4550992 complement(2353829..2354851) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2354851 4550992 MUL_2108 Mycobacterium ulcerans Agy99 hypothetical protein YP_906000.1 2353829 R 362242 CDS YP_906001.2 162138270 4550993 2355048..2356709 1 NC_008611.1 malate dehydrogenase; catalyzes the oxidation of malate to oxaloacetate; malate:quinone oxidoreductase 2356709 mqo 4550993 mqo Mycobacterium ulcerans Agy99 malate:quinone oxidoreductase YP_906001.2 2355048 D 362242 CDS YP_906002.1 118617670 4550994 2356586..2356996 1 NC_008611.1 cytoplasmic protein; function unknown, predicted acyltransferase activity; acyltransferase ElaA 2356996 elaA 4550994 elaA Mycobacterium ulcerans Agy99 acyltransferase ElaA YP_906002.1 2356586 D 362242 CDS YP_906003.1 118617671 4550995 2356993..2358843 1 NC_008611.1 cytoplasmic protein; function unknown, possibly introduces a magnesium ion into specific substrate/compound.; magnesium chelatase 2358843 4550995 MUL_2111 Mycobacterium ulcerans Agy99 magnesium chelatase YP_906003.1 2356993 D 362242 CDS YP_906004.1 118617672 4550996 2358865..2359479 1 NC_008611.1 catalyzes the formation of adenosylcob(III)yrinic acid a,c-diamide from cob(I)yrinic acid a,c-diamide; cob(I)yrinic acid a,c-diamide adenosyltransferase 2359479 cobO 4550996 cobO Mycobacterium ulcerans Agy99 cob(I)yrinic acid a,c-diamide adenosyltransferase YP_906004.1 2358865 D 362242 CDS YP_906005.1 118617673 4550997 2359574..2360950 1 NC_008611.1 responsible for the amidation of carboxylic groups at position A and C of cobyrinic acid or hydrogenobrynic acid; cobyrinic acid a,c-diamide synthase 2360950 cobB 4550997 cobB Mycobacterium ulcerans Agy99 cobyrinic acid a,c-diamide synthase YP_906005.1 2359574 D 362242 CDS YP_906006.1 118617674 4550998 2361128..2362333 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; involved in the biosynthesis of siroheme and cobalamin [catalytic activity: 2 S-adenosyl-L-methionine + uroporphyrin III = 2 S-adenosyl-L-homocysteine + sirohydrochlorin] SAM-dependent methyl transferase that methylates uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. it catalyzes also the conversion of precorrin-2 into siroheme (consisting of an oxidation and fe(2+) chelation); multifunctional enzyme siroheme synthase CysG 2362333 cysG 4550998 cysG Mycobacterium ulcerans Agy99 multifunctional enzyme siroheme synthase CysG YP_906006.1 2361128 D 362242 CDS YP_906007.1 118617675 4550999 2362367..2363959 1 NC_008611.1 membrane protein; thought to be involved in transport of undeterminated substrate (possibly drug) across the membrane (export): so responsible for the translocation of the substrate across the membrane.; integral membrane efflux protein EfpA 2363959 efpA 4550999 efpA Mycobacterium ulcerans Agy99 integral membrane efflux protein EfpA YP_906007.1 2362367 D 362242 CDS YP_906008.1 118617676 4551000 2364066..2365814 1 NC_008611.1 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro); prolyl-tRNA synthetase 2365814 proS 4551000 proS Mycobacterium ulcerans Agy99 prolyl-tRNA synthetase YP_906008.1 2364066 D 362242 CDS YP_906009.1 118617677 4550945 complement(2365827..2366315) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2366315 4550945 MUL_2117 Mycobacterium ulcerans Agy99 hypothetical protein YP_906009.1 2365827 R 362242 CDS YP_906010.1 118617678 4550946 complement(2366312..2366818) 1 NC_008611.1 membrane protein; hypothetical protein 2366818 4550946 MUL_2118 Mycobacterium ulcerans Agy99 hypothetical protein YP_906010.1 2366312 R 362242 CDS YP_906011.1 118617679 4550947 2367070..2367603 1 NC_008611.1 in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins; hypothetical protein 2367603 4550947 MUL_2119 Mycobacterium ulcerans Agy99 hypothetical protein YP_906011.1 2367070 D 362242 CDS YP_906012.1 118617680 4550948 2367600..2368643 1 NC_008611.1 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination; transcription elongation factor NusA 2368643 nusA 4550948 nusA Mycobacterium ulcerans Agy99 transcription elongation factor NusA YP_906012.1 2367600 D 362242 CDS YP_906013.1 118617681 4550949 2368822..2369109 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2369109 4550949 MUL_2121 Mycobacterium ulcerans Agy99 hypothetical protein YP_906013.1 2368822 D 362242 CDS YP_906014.1 118617682 4550950 2369174..2372011 1 NC_008611.1 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; translation initiation factor IF-2 2372011 infB 4550950 infB Mycobacterium ulcerans Agy99 translation initiation factor IF-2 YP_906014.1 2369174 D 362242 CDS YP_906015.1 118617683 4550951 2372024..2372551 1 NC_008611.1 associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock; ribosome-binding factor A 2372551 rbfA 4550951 rbfA Mycobacterium ulcerans Agy99 ribosome-binding factor A YP_906015.1 2372024 D 362242 CDS YP_906016.1 118617684 4550952 2372571..2373530 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2373530 4550952 MUL_2124 Mycobacterium ulcerans Agy99 hypothetical protein YP_906016.1 2372571 D 362242 CDS YP_906017.1 118617685 4550953 2373546..2374883 1 NC_008611.1 membrane protein; function unknown, induction by DNA damage.; DNA-damage-inducible protein F DinF 2374883 dinF 4550953 dinF Mycobacterium ulcerans Agy99 DNA-damage-inducible protein F DinF YP_906017.1 2373546 D 362242 CDS YP_906018.1 118617686 4550954 2374948..2375847 1 NC_008611.1 membrane protein; involved in active transport of SN-glycerol-3- phosphate across the membrane (import) responsible for the translocation of the substrate across the membrane.; SN-glycerol-3-phosphate transport integral membrane protein ABC transporter UgpA 2375847 ugpA 4550954 ugpA Mycobacterium ulcerans Agy99 SN-glycerol-3-phosphate transport integral membrane protein ABC transporter UgpA YP_906018.1 2374948 D 362242 CDS YP_906019.1 118617687 4550956 complement(2376320..2377366) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 2377366 4550956 MUL_2128 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_906019.1 2376320 R 362242 CDS YP_906020.1 118617688 4550957 2377843..2379018 1 NC_008611.1 membrane protein; PPE family protein 2379018 4550957 MUL_2129 Mycobacterium ulcerans Agy99 PPE family protein YP_906020.1 2377843 D 362242 CDS YP_906021.1 118617689 4550961 complement(2382612..2382932) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2382932 4550961 MUL_2133 Mycobacterium ulcerans Agy99 hypothetical protein YP_906021.1 2382612 R 362242 CDS YP_906022.1 118617690 4550962 complement(2383259..2384971) 1 NC_008611.1 cytoplasmic protein; function unknown, probably involved in cellular metabolism.; hydrolase 2384971 4550962 MUL_2134 Mycobacterium ulcerans Agy99 hydrolase YP_906022.1 2383259 R 362242 CDS YP_906023.1 118617691 4550963 complement(2385003..2385578) 1 NC_008611.1 secreted protein; hypothetical protein 2385578 4550963 MUL_2135 Mycobacterium ulcerans Agy99 hypothetical protein YP_906023.1 2385003 R 362242 CDS YP_906024.1 118617692 4550927 2385773..2386084 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2386084 4550927 MUL_2136 Mycobacterium ulcerans Agy99 hypothetical protein YP_906024.1 2385773 D 362242 CDS YP_906025.1 118617693 4550929 2387760..2388335 1 NC_008611.1 secreted protein; lipoprotein LppV_1 2388335 lppV_1 4550929 lppV_1 Mycobacterium ulcerans Agy99 lipoprotein LppV_1 YP_906025.1 2387760 D 362242 CDS YP_906026.1 118617694 4550930 2388393..2388965 1 NC_008611.1 secreted protein; lipoprotein LppV 2388965 lppV 4550930 lppV Mycobacterium ulcerans Agy99 lipoprotein LppV YP_906026.1 2388393 D 362242 CDS YP_906027.1 118617695 4550931 2389095..2390021 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2390021 4550931 MUL_2140 Mycobacterium ulcerans Agy99 hypothetical protein YP_906027.1 2389095 D 362242 CDS YP_906028.1 118617696 4550932 2390018..2390701 1 NC_008611.1 cytoplasmic protein; phosphopantetheinyl transferase. secondary metabolites biosynthesis, transport, and catabolism. Sfp- type phosphopantetheinyl transferase; phosphopantetheinyl transferase, PptII 2390701 pptII 4550932 pptII Mycobacterium ulcerans Agy99 phosphopantetheinyl transferase, PptII YP_906028.1 2390018 D 362242 CDS YP_906029.1 118617697 4550933 2390698..2391603 1 NC_008611.1 catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs; tRNA pseudouridine synthase B 2391603 truB 4550933 truB Mycobacterium ulcerans Agy99 tRNA pseudouridine synthase B YP_906029.1 2390698 D 362242 CDS YP_906030.1 118617698 4550934 2391710..2392912 1 NC_008611.1 membrane protein; possibly catalyzes the transfer of a great variety of lipids between membranes.; lipid-transfer protein 2392912 ltp1 4550934 ltp1 Mycobacterium ulcerans Agy99 lipid-transfer protein YP_906030.1 2391710 D 362242 CDS YP_906031.1 118617699 4550935 2392941..2394179 1 NC_008611.1 membrane protein; function unknown, but involved in lipid degradation.; acyl-CoA dehydrogenase FadE21 2394179 fadE21 4550935 fadE21 Mycobacterium ulcerans Agy99 acyl-CoA dehydrogenase FadE21 YP_906031.1 2392941 D 362242 CDS YP_906032.1 118617700 4550936 complement(2394196..2394888) 1 NC_008611.1 cytoplasmic protein; involved in transcriptional mechanism.; transcriptional repressor SirR 2394888 sirR 4550936 sirR Mycobacterium ulcerans Agy99 transcriptional repressor SirR YP_906032.1 2394196 R 362242 CDS YP_906033.1 118617701 4550937 2395069..2396043 1 NC_008611.1 catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities; bifunctional riboflavin kinase/FMN adenylyltransferase 2396043 ribF 4550937 ribF Mycobacterium ulcerans Agy99 bifunctional riboflavin kinase/FMN adenylyltransferase YP_906033.1 2395069 D 362242 CDS YP_906034.1 118617702 4550938 2396170..2396439 1 NC_008611.1 primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence; 30S ribosomal protein S15 2396439 rpsO 4550938 rpsO Mycobacterium ulcerans Agy99 30S ribosomal protein S15 YP_906034.1 2396170 D 362242 CDS YP_906035.1 118617703 4550939 2396451..2396984 1 NC_008611.1 secreted protein; lipoprotein LppU 2396984 lppU 4550939 lppU Mycobacterium ulcerans Agy99 lipoprotein LppU YP_906035.1 2396451 D 362242 CDS YP_906036.1 118617704 4550940 2397019..2397417 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2397417 4550940 MUL_2149 Mycobacterium ulcerans Agy99 hypothetical protein YP_906036.1 2397019 D 362242 CDS YP_906037.1 118617705 4550941 2397815..2400076 1 NC_008611.1 Detected in the membrane fraction by proteomics (2D- LC-MS/MS) Also detected in the cytoplamic fraction by LC- MS/MS and in the extracellular matrix fraction by proteomics.; cytoplasmic protein; involved in mRNA degradation. hydrolyses single- stranded polyribonucleotides processively in the 3' to 5' direction. involved in the RNA degradosome, a multi-enzyme complex important in RNA processing and messenger RNA degradation [catalytic activity: RNA(n+1) + phosphate = RNA(N) + a nucleoside diphosphate]; polynucleotide phosphorylase/polyadenylase 2400076 gpsI 4550941 gpsI Mycobacterium ulcerans Agy99 polynucleotide phosphorylase/polyadenylase YP_906037.1 2397815 D 362242 CDS YP_906038.1 118617706 4550943 complement(2401151..2402197) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 2402197 4550943 MUL_2152 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_906038.1 2401151 R 362242 CDS YP_906039.1 118617707 4550944 2402751..2403785 1 NC_008611.1 secreted protein; hypothetical protein 2403785 4550944 MUL_2153 Mycobacterium ulcerans Agy99 hypothetical protein YP_906039.1 2402751 D 362242 CDS YP_906040.1 118617708 4550816 complement(2403862..2404977) 1 NC_008611.1 Also detected in the cytoplasmic and membrane fractions by proteomics.; secreted protein; may play a role in cell wall synthesis as L-alanine is an important constituent of the peptidoglycan layer [catalytic activity: L-alanine + H(2)O + NAD(+) = pyruvate + NH(3) + NADH]; secreted L-alanine dehydrogenase Ald (40 kDa antigen) 2404977 ald 4550816 ald Mycobacterium ulcerans Agy99 secreted L-alanine dehydrogenase Ald (40 kDa antigen) YP_906040.1 2403862 R 362242 CDS YP_906041.1 118617709 4550817 2405173..2405607 1 NC_008611.1 cytoplasmic protein; involved in transcriptional mechanism.; Lrp/AsnC family transcriptional regulator 2405607 4550817 MUL_2155 Mycobacterium ulcerans Agy99 Lrp/AsnC family transcriptional regulator YP_906041.1 2405173 D 362242 CDS YP_906042.1 118617710 4550818 2405636..2406100 1 NC_008611.1 Also detected in the membrane fraction by proteomics.; cytoplasmic protein; hypothetical protein 2406100 4550818 MUL_2156 Mycobacterium ulcerans Agy99 hypothetical protein YP_906042.1 2405636 D 362242 CDS YP_906043.1 118617711 4550819 2406205..2407122 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2407122 4550819 MUL_2157 Mycobacterium ulcerans Agy99 hypothetical protein YP_906043.1 2406205 D 362242 CDS YP_906044.1 118617712 4550821 2408901..2409983 1 NC_008611.1 cytoplasmic protein; function unknown, probably involved in cellular metabolism.; oxidoreductase 2409983 4550821 MUL_2159 Mycobacterium ulcerans Agy99 oxidoreductase YP_906044.1 2408901 D 362242 CDS YP_906045.1 118617713 4550822 complement(2409989..2410630) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2410630 4550822 MUL_2160 Mycobacterium ulcerans Agy99 hypothetical protein YP_906045.1 2409989 R 362242 CDS YP_906046.1 118617714 4550823 2410751..2411776 1 NC_008611.1 cytoplasmic protein; function unknown, probably involved in cellular metabolism.; oxidoreductase 2411776 4550823 MUL_2161 Mycobacterium ulcerans Agy99 oxidoreductase YP_906046.1 2410751 D 362242 CDS YP_906047.1 118617715 4550824 2411847..2412872 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2412872 4550824 MUL_2162 Mycobacterium ulcerans Agy99 hypothetical protein YP_906047.1 2411847 D 362242 CDS YP_906048.1 118617716 4550826 2414320..2415057 1 NC_008611.1 catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate reductase 2415057 dapB 4550826 dapB Mycobacterium ulcerans Agy99 dihydrodipicolinate reductase YP_906048.1 2414320 D 362242 CDS YP_906049.1 118617717 4550827 2415065..2415529 1 NC_008611.1 secreted protein; hypothetical protein 2415529 4550827 MUL_2165 Mycobacterium ulcerans Agy99 hypothetical protein YP_906049.1 2415065 D 362242 CDS YP_906050.1 118617718 4550828 2415526..2415990 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2415990 4550828 MUL_2166 Mycobacterium ulcerans Agy99 hypothetical protein YP_906050.1 2415526 D 362242 CDS YP_906051.1 118617719 4550830 2416526..2417647 1 NC_008611.1 PPE44; membrane protein; function unknown. may be involved in virulence; PPE family protein 2417647 4550830 MUL_2167 Mycobacterium ulcerans Agy99 PPE family protein YP_906051.1 2416526 D 362242 CDS YP_906052.1 118617720 4550833 complement(2420473..2421519) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 2421519 4550833 MUL_2170 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_906052.1 2420473 R 362242 CDS YP_906053.1 118617721 4550642 2425638..2426420 1 NC_008611.1 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-(acyl-carrier-protein) reductase 2426420 fabG 4550642 fabG Mycobacterium ulcerans Agy99 3-ketoacyl-(acyl-carrier-protein) reductase YP_906053.1 2425638 D 362242 CDS YP_906054.1 118617722 4550644 complement(2426816..2427862) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 2427862 4550644 MUL_2175 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_906054.1 2426816 R 362242 CDS YP_906055.1 118617723 4550645 2428983..2430086 1 NC_008611.1 cytoplasmic protein; function unknown, but supposed involvement in lipid degradation.; acyl-CoA dehydrogenase FadE18_1 2430086 fadE18_1 4550645 fadE18_1 Mycobacterium ulcerans Agy99 acyl-CoA dehydrogenase FadE18_1 YP_906055.1 2428983 D 362242 CDS YP_906056.1 118617724 4550646 complement(2430109..2430849) 1 NC_008611.1 Detected in the secreted fraction by proteomics.; secreted protein; function unknown, probably involved in cellular metabolism.; alanine rich hydrolase 2430849 4550646 MUL_2177 Mycobacterium ulcerans Agy99 alanine rich hydrolase YP_906056.1 2430109 R 362242 CDS YP_906057.1 118617725 4550647 2430948..2431748 1 NC_008611.1 ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived; thymidylate synthase 2431748 thyA 4550647 thyA Mycobacterium ulcerans Agy99 thymidylate synthase YP_906057.1 2430948 D 362242 CDS YP_906058.1 118617726 4550648 2431756..2432253 1 NC_008611.1 cytoplasmic protein; essential step for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dump to dTMP [catalytic activity: 5,6,7,8- tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + NADPH]; dihydrofolate reductase DfrA 2432253 dfrA 4550648 dfrA Mycobacterium ulcerans Agy99 dihydrofolate reductase DfrA YP_906058.1 2431756 D 362242 CDS YP_906059.1 118617727 4550649 2432250..2433464 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2433464 4550649 MUL_2180 Mycobacterium ulcerans Agy99 hypothetical protein YP_906059.1 2432250 D 362242 CDS YP_906060.1 118617728 4550652 2436003..2436764 1 NC_008611.1 flavin dependent thymidylate synthase; ThyX; thymidylate synthase complementing protein; catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate; the enzyme from Mycobacterium tuberculosis forms homotetramers; uses FAD as a cofactor; FAD-dependent thymidylate synthase 2436764 thyX 4550652 thyX Mycobacterium ulcerans Agy99 FAD-dependent thymidylate synthase YP_906060.1 2436003 D 362242 CDS YP_906061.1 118617729 4550653 2436882..2437784 1 NC_008611.1 catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate synthase 2437784 dapA 4550653 dapA Mycobacterium ulcerans Agy99 dihydrodipicolinate synthase YP_906061.1 2436882 D 362242 CDS YP_906062.1 118617730 4550654 complement(2437850..2438167) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; C-term transposase for IS2404 2438167 4550654 MUL_2185 Mycobacterium ulcerans Agy99 C-term transposase for IS2404 YP_906062.1 2437850 R 362242 CDS YP_906063.1 118617731 4550655 complement(2438192..2438896) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; N-term transposase for IS2404 2438896 4550655 MUL_2186 Mycobacterium ulcerans Agy99 N-term transposase for IS2404 YP_906063.1 2438192 R 362242 CDS YP_906064.1 118617732 4550623 complement(2440037..2440486) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; hypothetical protein 2440486 4550623 MUL_2188 Mycobacterium ulcerans Agy99 hypothetical protein YP_906064.1 2440037 R 362242 CDS YP_906065.1 118617733 4550624 2440852..2441268 1 NC_008611.1 cytoplasmic protein; acts as a global negative controlling element, employing fe(2+) as a cofactor to bind the operator of the repressed genes. seems to regulate transcription of KatG gene.; ferric uptake regulation protein FurA 2441268 furA 4550624 furA Mycobacterium ulcerans Agy99 ferric uptake regulation protein FurA YP_906065.1 2440852 D 362242 CDS YP_906066.1 118617734 4550625 2441410..2443536 1 NC_008611.1 Also detected in the secreted protein fraction by 2D-LC-MS/MS.; cytoplasmic protein; multifunctional enzyme, exhibiting both a catalase, a broad-spectrum peroxidase, and a peroxynitritase activities. may play a role in the intracellular survival of mycobacteria within macrophages; protection against reactive oxygen and nitrogen intermediates produced by phagocytic cells. seems regulated by SigB [catalytic activity: 2 H(2)O(2) = O(2) + 2 H(2)O]; catalase-peroxidase-peroxynitritase T KatG 2443536 katG 4550625 katG Mycobacterium ulcerans Agy99 catalase-peroxidase-peroxynitritase T KatG YP_906066.1 2441410 D 362242 CDS YP_906067.1 118617735 4550626 complement(2443443..2445380) 1 NC_008611.1 membrane protein; high-affinity uptake of glycine betaine. supposed responsible for the translocation of the substrate across the membrane.; glycine betaine transport integral membrane protein BetP 2445380 betP 4550626 betP Mycobacterium ulcerans Agy99 glycine betaine transport integral membrane protein BetP YP_906067.1 2443443 R 362242 CDS YP_906068.1 118617736 4550627 complement(2445727..2446773) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 2446773 4550627 MUL_2192 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_906068.1 2445727 R 362242 CDS YP_906069.1 118617737 4550630 2449447..2450493 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 2450493 4550630 MUL_2196 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_906069.1 2449447 D 362242 CDS YP_906070.1 118617738 4550631 complement(2453245..2453793) 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; hypothetical protein 2453793 4550631 MUL_2197 Mycobacterium ulcerans Agy99 hypothetical protein YP_906070.1 2453245 R 362242 CDS YP_906071.1 118617739 4550632 complement(2453903..2454532) 1 NC_008611.1 cytoplasmic protein; function unknown, probably involved in cellular metabolism; nitroreductase 2454532 4550632 MUL_2198 Mycobacterium ulcerans Agy99 nitroreductase YP_906071.1 2453903 R 362242 CDS YP_906072.1 118617740 4550634 2455743..2457707 1 NC_008611.1 membrane protein; involved in signal transduction (via phosphorylation) thought to be involved in membrane transport. phosphorylates the peptide substrate myelin basic protein (MBP) at serine and threonine residues [catalytic activity: ATP + a protein = ADP + a phosphoprotein]; membrane-anchored serine/threonine-protein kinase 2457707 4550634 MUL_2200 Mycobacterium ulcerans Agy99 membrane-anchored serine/threonine-protein kinase YP_906072.1 2455743 D 362242 CDS YP_906073.1 118617741 4550635 complement(2457915..2458244) 1 NC_008611.1 cytoplasmic protein; function unknown.; hypothetical protein 2458244 4550635 MUL_2201 Mycobacterium ulcerans Agy99 hypothetical protein YP_906073.1 2457915 R 362242 CDS YP_906074.1 118617742 4550636 2458333..2458905 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS. Also detected in the membrane fraction by proteomics (2D-LC-MS/MS); cytoplasmic protein; hypothetical protein 2458905 4550636 MUL_2202 Mycobacterium ulcerans Agy99 hypothetical protein YP_906074.1 2458333 D 362242 CDS YP_906075.1 118617743 4550639 complement(2462531..2463001) 1 NC_008611.1 Also detected in the extracellular matrix and membrane fraction by proteomics.; cytoplasmic protein; hypothetical protein 2463001 4550639 MUL_2205 Mycobacterium ulcerans Agy99 hypothetical protein YP_906075.1 2462531 R 362242 CDS YP_906076.1 118617744 4550608 complement(2469261..2469818) 1 NC_008611.1 secreted protein; function unknown. secreted protein.; hypothetical protein 2469818 4550608 MUL_2208 Mycobacterium ulcerans Agy99 hypothetical protein YP_906076.1 2469261 R 362242 CDS YP_906077.1 118617745 4550609 2470412..2471383 1 NC_008611.1 cytoplasmic protein; thought to be involved in fatty acid degradation. FadB and FadA are the alpha and BetA subunits of the multifunctional enzyme complex of the fatty acid degradation cycle.; oxidoreductase 2471383 4550609 MUL_2209 Mycobacterium ulcerans Agy99 oxidoreductase YP_906077.1 2470412 D 362242 CDS YP_906078.1 118617746 4550610 2471577..2472005 1 NC_008611.1 membrane protein; function unknown, unknown, contains a C-term cellobiohydrolase a (1,4-beta-cellobiosidase a) domain and a N-term cellulose-binding domain (CBD) domain. the CBD is found either at the N-term or at the C-term of endoglucanases, cellobiohydrolases (exoglucanases), or xylanases; chitinase/cellulase 2472005 4550610 MUL_2210 Mycobacterium ulcerans Agy99 chitinase/cellulase YP_906078.1 2471577 D 362242 CDS YP_906079.1 118617747 4550613 complement(2474337..2474669) 1 NC_008611.1 cytoplasmic protein; could be involved in the catabolism of catechol to succinate- and acetyl-CoA in the beta-ketoadipate pathway (at the third step) [catalytic activity: 2,5-dihydro-5- oxofuran-2-acetate = 3,4-dihydro-5-oxofuran-2-acetate]; muconolactone isomerase 2474669 4550613 MUL_2213 Mycobacterium ulcerans Agy99 muconolactone isomerase YP_906079.1 2474337 R 362242 CDS YP_906080.1 118617748 4550614 2474844..2476238 1 NC_008611.1 E3 component of alpha keto acid dehydrogenase complexes LpdC; forms a homodimer; binds one molecule of FAD monomer; catalyzes NAD+-dependent oxidation of dihydrolipoyl cofactors that are covalently linked to the E2 component; dihydrolipoamide dehydrogenase 2476238 lpd 4550614 lpd Mycobacterium ulcerans Agy99 dihydrolipoamide dehydrogenase YP_906080.1 2474844 D 362242 CDS YP_906081.1 118617749 4550615 2476241..2476516 1 NC_008611.1 membrane protein; hypothetical protein 2476516 4550615 MUL_2215 Mycobacterium ulcerans Agy99 hypothetical protein YP_906081.1 2476241 D 362242 CDS YP_906082.1 118617750 4550616 complement(2476522..2476716) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2476716 4550616 MUL_2216 Mycobacterium ulcerans Agy99 hypothetical protein YP_906082.1 2476522 R 362242 CDS YP_906083.1 118617751 4550617 complement(2476797..2477843) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 2477843 4550617 MUL_2217 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_906083.1 2476797 R 362242 CDS YP_906084.1 118617752 4550619 2478359..2479693 1 NC_008611.1 cytoplasmic protein; required for the transposition of the insertion element IS2606.; transposase for IS2606 2479693 4550619 MUL_2219 Mycobacterium ulcerans Agy99 transposase for IS2606 YP_906084.1 2478359 D 362242 CDS YP_906085.1 118617753 4550620 complement(2480160..2480987) 1 NC_008611.1 secreted protein; function unknown. possible secreted protein.; hypothetical protein 2480987 4550620 MUL_2220 Mycobacterium ulcerans Agy99 hypothetical protein YP_906085.1 2480160 R 362242 CDS YP_906086.1 118617754 4550589 2482652..2483941 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2483941 4550589 MUL_2223 Mycobacterium ulcerans Agy99 hypothetical protein YP_906086.1 2482652 D 362242 CDS YP_906087.1 118617755 4550592 2486508..2486741 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; hypothetical protein 2486741 4550592 MUL_2228 Mycobacterium ulcerans Agy99 hypothetical protein YP_906087.1 2486508 D 362242 CDS YP_906088.1 118617756 4550594 2487587..2488291 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; N-term transposase for IS2404 2488291 4550594 MUL_2230 Mycobacterium ulcerans Agy99 N-term transposase for IS2404 YP_906088.1 2487587 D 362242 CDS YP_906089.1 118617757 4550595 2488316..2488633 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; C-term transposase for IS2404 2488633 4550595 MUL_2231 Mycobacterium ulcerans Agy99 C-term transposase for IS2404 YP_906089.1 2488316 D 362242 CDS YP_906090.1 118617758 4550596 2488814..2489263 1 NC_008611.1 Also detected in the extracellular matrix by proteomics, and in the membrane fraction.; cytoplasmic protein; function unknown. may be involved in a chaperoning process.; molecular chaperone (small heat shock protein) 2489263 4550596 MUL_2232 Mycobacterium ulcerans Agy99 molecular chaperone (small heat shock protein) YP_906090.1 2488814 D 362242 CDS YP_906091.1 118617759 4550597 2489971..2490417 1 NC_008611.1 cytoplasmic protein; involved in the biosynthesis of tetrahydrofolate (at the first step) [catalytic activity: GTP + 2 H(2)O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3- trihydroxypropyl)DiHYD ro pteridine triphosphate]; GTP cyclohydrolase I FolE_1 2490417 folE_1 4550597 folE_1 Mycobacterium ulcerans Agy99 GTP cyclohydrolase I FolE_1 YP_906091.1 2489971 D 362242 CDS YP_906092.1 118617760 4550598 complement(2490452..2491339) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS) Also detected in the cytoplasmic and extracellular matrix fractions by proteomics.; membrane protein; hypothetical protein 2491339 4550598 MUL_2234 Mycobacterium ulcerans Agy99 hypothetical protein YP_906092.1 2490452 R 362242 CDS YP_906093.1 118617761 4550600 complement(2491790..2492674) 1 NC_008611.1 membrane protein; function unknown. possibly involved in signal transduction mechanisms.; hypothetical protein 2492674 4550600 MUL_2236 Mycobacterium ulcerans Agy99 hypothetical protein YP_906093.1 2491790 R 362242 CDS YP_906094.1 118617762 4550601 complement(2492843..2493109) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2493109 4550601 MUL_2237 Mycobacterium ulcerans Agy99 hypothetical protein YP_906094.1 2492843 R 362242 CDS YP_906095.1 118617763 4550602 complement(2493106..2493558) 1 NC_008611.1 cytoplasmic protein; the sigma factor is an initiation factor that promotes attachment of the RNA polymerase to specific initiation sites and then is released.; alternative RNA polymerase sigma factor 2493558 4550602 MUL_2238 Mycobacterium ulcerans Agy99 alternative RNA polymerase sigma factor YP_906095.1 2493106 R 362242 CDS YP_906096.1 118617764 4550603 complement(2493741..2494823) 1 NC_008611.1 membrane protein; function unknown. possibly involved in lipid metabolism.; hypothetical protein 2494823 4550603 MUL_2239 Mycobacterium ulcerans Agy99 hypothetical protein YP_906096.1 2493741 R 362242 CDS YP_906097.1 118617765 4550604 complement(2494995..2495519) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2495519 4550604 MUL_2241 Mycobacterium ulcerans Agy99 hypothetical protein YP_906097.1 2494995 R 362242 CDS YP_906098.1 118617766 4550605 2495678..2495869 1 NC_008611.1 hypothetical protein 2495869 4550605 MUL_2242 Mycobacterium ulcerans Agy99 hypothetical protein YP_906098.1 2495678 D 362242 CDS YP_906099.1 118617767 4550570 complement(2495925..2496215) 1 NC_008611.1 secreted protein; EsaT-6 family protein 2496215 esxR 4550570 esxR Mycobacterium ulcerans Agy99 EsaT-6 family protein YP_906099.1 2495925 R 362242 CDS YP_906100.1 118617768 4550572 complement(2496583..2497869) 1 NC_008611.1 membrane protein; PPE family protein 2497869 4550572 MUL_2245 Mycobacterium ulcerans Agy99 PPE family protein YP_906100.1 2496583 R 362242 CDS YP_906101.1 118617769 4550573 complement(2497880..2498185) 1 NC_008611.1 secreted protein; PE family protein 2498185 4550573 MUL_2246 Mycobacterium ulcerans Agy99 PE family protein YP_906101.1 2497880 R 362242 CDS YP_906102.1 118617770 4550574 complement(2498760..2499422) 1 NC_008611.1 membrane protein; PPE family protein 2499422 4550574 MUL_2247 Mycobacterium ulcerans Agy99 PPE family protein YP_906102.1 2498760 R 362242 CDS YP_906103.1 118617771 4550576 complement(2501416..2502252) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2502252 4550576 MUL_2249 Mycobacterium ulcerans Agy99 hypothetical protein YP_906103.1 2501416 R 362242 CDS YP_906104.1 118617772 4550577 complement(2502459..2504369) 1 NC_008611.1 membrane protein; PE-PGRS family protein 2504369 4550577 MUL_2250 Mycobacterium ulcerans Agy99 PE-PGRS family protein YP_906104.1 2502459 R 362242 CDS YP_906105.1 118617773 4550578 complement(2504532..2505497) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; hypothetical protein 2505497 4550578 MUL_2251 Mycobacterium ulcerans Agy99 hypothetical protein YP_906105.1 2504532 R 362242 CDS YP_906106.1 118617774 4550579 complement(2505600..2506670) 1 NC_008611.1 membrane protein; thought to be involved in active transport of sugar across the membrane (import) responsible for energy coupling to the transport system.; sugar-transport ATP-binding protein ABC transporter 2506670 4550579 MUL_2252 Mycobacterium ulcerans Agy99 sugar-transport ATP-binding protein ABC transporter YP_906106.1 2505600 R 362242 CDS YP_906107.1 118617775 4550580 complement(2506676..2507518) 1 NC_008611.1 membrane protein; sugar ABC transporter 2507518 4550580 MUL_2253 Mycobacterium ulcerans Agy99 sugar ABC transporter YP_906107.1 2506676 R 362242 CDS YP_906108.1 118617776 4550581 complement(2507505..2508458) 1 NC_008611.1 membrane protein; thought to be involved in active transport of sugar across the membrane (import) responsible for the translocation of the substrate across the membrane.; ABC-type sugar transport integral membrane protein 2508458 4550581 MUL_2254 Mycobacterium ulcerans Agy99 ABC-type sugar transport integral membrane protein YP_906108.1 2507505 R 362242 CDS YP_906109.1 118617777 4550584 complement(2510652..2511212) 1 NC_008611.1 cytoplasmic protein; converts amides such as nicotinamide to corresponding acid.; pyrazinamidase/nicotinamidase, PncA 2511212 pncA 4550584 pncA Mycobacterium ulcerans Agy99 pyrazinamidase/nicotinamidase, PncA YP_906109.1 2510652 R 362242 CDS YP_906110.1 118617778 4550585 2511308..2512123 1 NC_008611.1 membrane protein; hypothetical protein 2512123 4550585 MUL_2258 Mycobacterium ulcerans Agy99 hypothetical protein YP_906110.1 2511308 D 362242 CDS YP_906111.1 118617779 4550586 complement(2512120..2512635) 1 NC_008611.1 membrane protein; function unknown, in general gluconate kinase catalyzes the phosphoryl transfer from ATP to gluconate. the resulting product gluconate-6-phosphate is an important precursor of gluconate metabolism.; gluconate kinase 2512635 4550586 MUL_2259 Mycobacterium ulcerans Agy99 gluconate kinase YP_906111.1 2512120 R 362242 CDS YP_906112.1 118617780 4550588 complement(2514633..2516138) 1 NC_008611.1 cytoplasmic protein; converts unknown esters to corresponding free acid and alcohol; carboxylesterase, LipT 2516138 lipT 4550588 lipT Mycobacterium ulcerans Agy99 carboxylesterase, LipT YP_906112.1 2514633 R 362242 CDS YP_906113.1 118617781 4550538 2516217..2516897 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; lipoprotein LppI 2516897 lppI 4550538 lppI Mycobacterium ulcerans Agy99 lipoprotein LppI YP_906113.1 2516217 D 362242 CDS YP_906114.1 118617782 4550539 2517227..2517544 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2517544 4550539 MUL_2263 Mycobacterium ulcerans Agy99 hypothetical protein YP_906114.1 2517227 D 362242 CDS YP_906115.1 118617783 4550540 2518033..2518413 1 NC_008611.1 membrane protein; hypothetical protein 2518413 4550540 MUL_2264 Mycobacterium ulcerans Agy99 hypothetical protein YP_906115.1 2518033 D 362242 CDS YP_906116.1 118617784 4550541 complement(2518555..2521215) 1 NC_008611.1 Also detected in the cytoplasmic fraction by 2D-LC- MS/MS.; membrane protein; hypothetical protein 2521215 4550541 MUL_2265 Mycobacterium ulcerans Agy99 hypothetical protein YP_906116.1 2518555 R 362242 CDS YP_906117.1 118617785 4550542 complement(2521288..2533863) 1 NC_008611.1 cytoplasmic protein; required for mycoketide synthesis.; polyketide synthase, Pks12 2533863 pks12 4550542 pks12 Mycobacterium ulcerans Agy99 polyketide synthase, Pks12 YP_906117.1 2521288 R 362242 CDS YP_906118.1 118617786 4550543 complement(2534194..2534553) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2534553 4550543 MUL_2267 Mycobacterium ulcerans Agy99 hypothetical protein YP_906118.1 2534194 R 362242 CDS YP_906119.1 118617787 4550544 2534710..2535045 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2535045 4550544 MUL_2268 Mycobacterium ulcerans Agy99 hypothetical protein YP_906119.1 2534710 D 362242 CDS YP_906120.1 118617788 4550545 complement(2535066..2535872) 1 NC_008611.1 This gene in two parts compared with MTB orthologue. Potential pseudogene but given same arrangement in M. marinum then this possibility seems less likely.; cytoplasmic protein; transfers mannose from GDP-mannose to all endogenous polyprenol-phosphates in mycobacterium tuberculosis; C-term polyprenol-monophosphomannose synthase Ppm1B 2535872 ppm1B 4550545 ppm1B Mycobacterium ulcerans Agy99 C-term polyprenol-monophosphomannose synthase Ppm1B YP_906120.1 2535066 R 362242 CDS YP_906121.1 118617789 4550546 complement(2535898..2537715) 1 NC_008611.1 cytoplasmic protein; transfers mannose from GDP-mannose to all endogenous polyprenol-phosphates in mycobacterium tuberculosis; N-term polyprenol-monophosphomannose synthase Ppm1A 2537715 ppm1A 4550546 ppm1A Mycobacterium ulcerans Agy99 N-term polyprenol-monophosphomannose synthase Ppm1A YP_906121.1 2535898 R 362242 CDS YP_906122.1 118617790 4550547 complement(2538005..2539609) 1 NC_008611.1 domain identity with predicted metal-dependent hydrolases with the TIM-barrel folds; hypothetical protein 2539609 4550547 MUL_2270 Mycobacterium ulcerans Agy99 hypothetical protein YP_906122.1 2538005 R 362242 CDS YP_906123.1 118617791 4550548 complement(2539640..2540272) 1 NC_008611.1 F exclusion of bacteriophage T7; overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7; interacts with the F plasmid-encoded PifA protein; inner membrane protein; FxsA 2540272 fxsA 4550548 fxsA Mycobacterium ulcerans Agy99 FxsA YP_906123.1 2539640 R 362242 CDS YP_906124.1 118617792 4550549 2540345..2541055 1 NC_008611.1 cytoplasmic protein; domain identity with dienelactone hydrolases; hypothetical protein 2541055 4550549 MUL_2272 Mycobacterium ulcerans Agy99 hypothetical protein YP_906124.1 2540345 D 362242 CDS YP_906125.1 118617793 4550550 2541330..2542934 1 NC_008611.1 membrane protein; hypothetical protein 2542934 4550550 MUL_2273 Mycobacterium ulcerans Agy99 hypothetical protein YP_906125.1 2541330 D 362242 CDS YP_906126.1 118617794 4550551 complement(2542931..2544538) 1 NC_008611.1 membrane protein; transmembrane protein 2544538 4550551 MUL_2274 Mycobacterium ulcerans Agy99 transmembrane protein YP_906126.1 2542931 R 362242 CDS YP_906127.1 118617795 4550552 complement(2544663..2545541) 1 NC_008611.1 membrane protein; function unknown. domain identity to ThiJ-like intracellular proteases/amidases; hypothetical protein 2545541 4550552 MUL_2275 Mycobacterium ulcerans Agy99 hypothetical protein YP_906127.1 2544663 R 362242 CDS YP_906128.1 118617796 4550553 complement(2545552..2545935) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2545935 4550553 MUL_2276 Mycobacterium ulcerans Agy99 hypothetical protein YP_906128.1 2545552 R 362242 CDS YP_906129.1 118617797 4550554 complement(2545986..2549558) 1 NC_008611.1 with CobST catalyzes the formation of cobyrinic acid a,c-diamide from hydrogenobyrinic acid a,c-diamide in an ATP-dependent manner; involved in porphyrin and chlorophyll metabolism; vitamin B12 metabolism; cobaltochelatase subunit CobN 2549558 cobN 4550554 cobN Mycobacterium ulcerans Agy99 cobaltochelatase subunit CobN YP_906129.1 2545986 R 362242 CDS YP_906130.1 118617798 4550555 complement(2549551..2549772) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2549772 4550555 MUL_2278 Mycobacterium ulcerans Agy99 hypothetical protein YP_906130.1 2549551 R 362242 CDS YP_906131.1 118617799 4550556 complement(2549838..2551469) 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; membrane protein; membrane-bound oxidoreductase 2551469 4550556 MUL_2279 Mycobacterium ulcerans Agy99 membrane-bound oxidoreductase YP_906131.1 2549838 R 362242 CDS YP_906132.1 118617800 4550520 complement(2551543..2551860) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; C-term transposase for IS2404 2551860 4550520 MUL_2280 Mycobacterium ulcerans Agy99 C-term transposase for IS2404 YP_906132.1 2551543 R 362242 CDS YP_906133.1 118617801 4550521 complement(2551885..2552589) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; N-term transposase for IS2404 2552589 4550521 MUL_2281 Mycobacterium ulcerans Agy99 N-term transposase for IS2404 YP_906133.1 2551885 R 362242 CDS YP_906134.1 118617802 4550522 2552918..2553745 1 NC_008611.1 cytoplasmic protein; cellular metabolism; short chain dehydrogenase 2553745 4550522 MUL_2282 Mycobacterium ulcerans Agy99 short chain dehydrogenase YP_906134.1 2552918 D 362242 CDS YP_906135.1 118617803 4550523 2553750..2554637 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2554637 4550523 MUL_2283 Mycobacterium ulcerans Agy99 hypothetical protein YP_906135.1 2553750 D 362242 CDS YP_906136.1 118617804 4550524 complement(2554774..2555394) 1 NC_008611.1 cytoplasmic protein; function unknown. contains adenylate cyclase domain; hypothetical protein 2555394 4550524 MUL_2284 Mycobacterium ulcerans Agy99 hypothetical protein YP_906136.1 2554774 R 362242 CDS YP_906137.1 118617805 4550526 2558891..2560000 1 NC_008611.1 cobalamin biosynthesis protein 2560000 4550526 MUL_2288 Mycobacterium ulcerans Agy99 cobalamin biosynthesis protein YP_906137.1 2558891 D 362242 CDS YP_906138.1 118617806 4550527 2560018..2560644 1 NC_008611.1 catalyzes the interconversion of precorrin-8X and hydrogenobyrinate; precorrin-8X methylmutase 2560644 cobH 4550527 cobH Mycobacterium ulcerans Agy99 precorrin-8X methylmutase YP_906138.1 2560018 D 362242 CDS YP_906139.1 118617807 4550528 2560641..2562110 1 NC_008611.1 detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; involved in cobalamin biosynthesis; bifunctional protein, CobI-CobJ fusion protein 2562110 cobI 4550528 cobI Mycobacterium ulcerans Agy99 bifunctional protein, CobI-CobJ fusion protein YP_906139.1 2560641 D 362242 CDS YP_906140.1 118617808 4550529 complement(2562107..2563333) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2563333 4550529 MUL_2291 Mycobacterium ulcerans Agy99 hypothetical protein YP_906140.1 2562107 R 362242 CDS YP_906141.1 118617809 4550531 complement(2566357..2566788) 1 NC_008611.1 membrane protein; membrane transporter 2566788 mmpS4_1 4550531 mmpS4_1 Mycobacterium ulcerans Agy99 membrane transporter YP_906141.1 2566357 R 362242 CDS YP_906142.1 118617810 4550532 complement(2567140..2568075) 1 NC_008611.1 Also detected in the cytoplasmic fraction by proteomics; membrane protein; hydrolyses beta-lactams to generate corresponding beta-amino acid [catalytic activity: a beta-lactam + H(2)O = a substituted beta-amino acid]; class a beta-lactamase, BlaC 2568075 blaC 4550532 blaC Mycobacterium ulcerans Agy99 class a beta-lactamase, BlaC YP_906142.1 2567140 R 362242 CDS YP_906143.1 118617811 4550533 2568205..2568765 1 NC_008611.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; RNA polymerase sigma factor SigC 2568765 sigC 4550533 sigC Mycobacterium ulcerans Agy99 RNA polymerase sigma factor SigC YP_906143.1 2568205 D 362242 CDS YP_906144.1 118617812 4550534 complement(2568771..2569499) 1 NC_008611.1 CobK/CbiJ; there are 2 pathways for cobalamin (vitamin B12) production, one aerobic (ex. P. denitrificans), the other anaerobic (ex. S. typhimurium); the CobK/CbiJ perform similar reactions in both; the anaerobic pathway includes the use of a chelated cobalt ion in order for ring contraction to occur; CobK thus converts precorrin 6 into dihydro-precorrin 6 while CbiJ converts cobalt-precorrin 6 into cobalt-deihydro-precorrin 6; cobalt-precorrin-6x reductase 2569499 cobK 4550534 cobK Mycobacterium ulcerans Agy99 cobalt-precorrin-6x reductase YP_906144.1 2568771 R 362242 CDS YP_906145.1 118617813 4550535 complement(2569496..2570245) 1 NC_008611.1 cytoplasmic protein; involved in cobalamin biosynthesis; precorrin-4 C11-methyltransferase, CobM 2570245 cobM 4550535 cobM Mycobacterium ulcerans Agy99 precorrin-4 C11-methyltransferase, CobM YP_906145.1 2569496 R 362242 CDS YP_906146.1 118617814 4550536 complement(2570242..2571414) 1 NC_008611.1 cytoplasmic protein; precorrin-6y methyltransferase, CobL 2571414 cobL 4550536 cobL Mycobacterium ulcerans Agy99 precorrin-6y methyltransferase, CobL YP_906146.1 2570242 R 362242 CDS YP_906147.1 118617815 4550537 complement(2571411..2572160) 1 NC_008611.1 cytoplasmic protein; short chain dehydrogenase 2572160 4550537 MUL_2299 Mycobacterium ulcerans Agy99 short chain dehydrogenase YP_906147.1 2571411 R 362242 CDS YP_906148.1 118617816 4550483 2572193..2572606 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS. Also detected in the membrane fraction by proteomics (LC-MS/MS); cytoplasmic protein; hypothetical protein 2572606 4550483 MUL_2300 Mycobacterium ulcerans Agy99 hypothetical protein YP_906148.1 2572193 D 362242 CDS YP_906149.1 118617817 4550486 2574349..2575395 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 2575395 4550486 MUL_2303 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_906149.1 2574349 D 362242 CDS YP_906150.1 118617818 4550487 complement(2576340..2577185) 1 NC_008611.1 membrane protein; hypothetical protein 2577185 4550487 MUL_2304 Mycobacterium ulcerans Agy99 hypothetical protein YP_906150.1 2576340 R 362242 CDS YP_906151.1 118617819 4550488 complement(2577182..2579467) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2579467 4550488 MUL_2305 Mycobacterium ulcerans Agy99 hypothetical protein YP_906151.1 2577182 R 362242 CDS YP_906152.1 118617820 4550489 2580144..2580398 1 NC_008611.1 cytoplasmic protein; transposition of an insertion sequence; transposase 2580398 4550489 MUL_2306 Mycobacterium ulcerans Agy99 transposase YP_906152.1 2580144 D 362242 CDS YP_906153.1 118617821 4550490 2580689..2581201 1 NC_008611.1 secreted protein; hypothetical protein 2581201 4550490 MUL_2307 Mycobacterium ulcerans Agy99 hypothetical protein YP_906153.1 2580689 D 362242 CDS YP_906154.1 118617822 4550491 2581255..2581704 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; membrane protein; hypothetical protein 2581704 4550491 MUL_2308 Mycobacterium ulcerans Agy99 hypothetical protein YP_906154.1 2581255 D 362242 CDS YP_906155.1 118617823 4550492 2582380..2582889 1 NC_008611.1 membrane protein; hypothetical protein 2582889 4550492 MUL_2309 Mycobacterium ulcerans Agy99 hypothetical protein YP_906155.1 2582380 D 362242 CDS YP_906156.1 118617824 4550494 2585051..2586019 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2586019 4550494 MUL_2312 Mycobacterium ulcerans Agy99 hypothetical protein YP_906156.1 2585051 D 362242 CDS YP_906157.1 118617825 4550495 complement(2586116..2589457) 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; hypothetical protein 2589457 4550495 MUL_2313 Mycobacterium ulcerans Agy99 hypothetical protein YP_906157.1 2586116 R 362242 CDS YP_906158.1 118617826 4550496 complement(2589450..2590145) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2590145 4550496 MUL_2314 Mycobacterium ulcerans Agy99 hypothetical protein YP_906158.1 2589450 R 362242 CDS YP_906159.1 118617827 4550497 complement(2590186..2591625) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2591625 4550497 MUL_2315 Mycobacterium ulcerans Agy99 hypothetical protein YP_906159.1 2590186 R 362242 CDS YP_906160.1 118617828 4550498 complement(2592285..2592548) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2592548 4550498 MUL_2317 Mycobacterium ulcerans Agy99 hypothetical protein YP_906160.1 2592285 R 362242 CDS YP_906161.1 118617829 4550499 complement(2592555..2595149) 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; hypothetical protein 2595149 4550499 MUL_2318 Mycobacterium ulcerans Agy99 hypothetical protein YP_906161.1 2592555 R 362242 CDS YP_906162.1 118617830 4550465 complement(2595346..2597589) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2597589 4550465 MUL_2320 Mycobacterium ulcerans Agy99 hypothetical protein YP_906162.1 2595346 R 362242 CDS YP_906163.1 118617831 4550466 complement(2597626..2598753) 1 NC_008611.1 Detected in the cytoplamic fraction by 2D-LC- MS/MS.; cytoplasmic protein; hydrolysis of peptide bonds; dipeptidase PepE 2598753 pepE 4550466 pepE Mycobacterium ulcerans Agy99 dipeptidase PepE YP_906163.1 2597626 R 362242 CDS YP_906164.1 118617832 4550467 2598877..2599833 1 NC_008611.1 cytoplasmic protein; involved in DNA metabolism; 5'-3' exonuclease 2599833 4550467 MUL_2322 Mycobacterium ulcerans Agy99 5'-3' exonuclease YP_906164.1 2598877 D 362242 CDS YP_906165.1 118617833 4550468 complement(2599846..2600610) 1 NC_008611.1 Detected in the membrane fraction by proteomics (2D- LC-MS/MS); membrane protein; hypothetical protein 2600610 4550468 MUL_2323 Mycobacterium ulcerans Agy99 hypothetical protein YP_906165.1 2599846 R 362242 CDS YP_906166.1 118617834 4550469 complement(2600717..2603473) 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; DNA helicase activity.; ATP-dependent DNA helicase HelY 2603473 helY 4550469 helY Mycobacterium ulcerans Agy99 ATP-dependent DNA helicase HelY YP_906166.1 2600717 R 362242 CDS YP_906167.1 118617835 4550470 complement(2603561..2604511) 1 NC_008611.1 membrane protein; involved in proteins export: required for correct localization of precursor proteins bearing signal peptides with the twin arginine conserved motif S/T-R-R-X-F-L-K. this sec-independent pathway is termed tat for twin- arginine translocation system.; sec-independent protein translocase transmembrane protein TatC 2604511 tatC 4550470 tatC Mycobacterium ulcerans Agy99 sec-independent protein translocase transmembrane protein TatC YP_906167.1 2603561 R 362242 CDS YP_906168.1 118617836 4550471 complement(2604557..2604823) 1 NC_008611.1 TatA; similar to TatE that is found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes; twin arginine translocase protein A 2604823 tatA 4550471 tatA Mycobacterium ulcerans Agy99 twin arginine translocase protein A YP_906168.1 2604557 R 362242 CDS YP_906169.1 118617837 4550472 complement(2604950..2605918) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2605918 4550472 MUL_2327 Mycobacterium ulcerans Agy99 hypothetical protein YP_906169.1 2604950 R 362242 CDS YP_906170.1 118617838 4550473 complement(2605968..2606966) 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; contains domain homology to transcriptional regulators; hypothetical protein 2606966 4550473 MUL_2328 Mycobacterium ulcerans Agy99 hypothetical protein YP_906170.1 2605968 R 362242 CDS YP_906171.1 118617839 4550474 complement(2607020..2608378) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2608378 4550474 MUL_2329 Mycobacterium ulcerans Agy99 hypothetical protein YP_906171.1 2607020 R 362242 CDS YP_906172.1 118617840 4550475 complement(2608436..2609239) 1 NC_008611.1 Detected in the cytoplasmic, membrane and secreted protein fractions by proteomics.; cytoplasmic protein; protein degradation; proteasome (alpha subunit) PrcA 2609239 prcA 4550475 prcA Mycobacterium ulcerans Agy99 proteasome (alpha subunit) PrcA YP_906172.1 2608436 R 362242 CDS YP_906173.1 118617841 4550476 complement(2609236..2610105) 1 NC_008611.1 Detected in the cytoplasmic, the membrane and the secreted fractions by proteomics.; cytoplasmic protein; protein degradation; proteasome (beta subunit) PrcB 2610105 prcB 4550476 prcB Mycobacterium ulcerans Agy99 proteasome (beta subunit) PrcB YP_906173.1 2609236 R 362242 CDS YP_906174.1 118617842 4550477 complement(2610102..2610296) 1 NC_008611.1 Detected in the cytoplasmic ans secreted fractions by 2D-LC-MS/MS.; cytoplasmic protein; hypothetical protein 2610296 4550477 MUL_2332 Mycobacterium ulcerans Agy99 hypothetical protein YP_906174.1 2610102 R 362242 CDS YP_906175.1 118617843 4550478 complement(2610468..2611976) 1 NC_008611.1 Also detected in the membrane fraction by proteomics (2D-LC-MS/MS); cytoplasmic protein; hypothetical protein 2611976 4550478 MUL_2333 Mycobacterium ulcerans Agy99 hypothetical protein YP_906175.1 2610468 R 362242 CDS YP_906176.1 118617844 4550479 2612273..2613370 1 NC_008611.1 Detected in the cytoplasmic fraction by proteomics.; cytoplasmic protein; hypothetical protein 2613370 4550479 MUL_2334 Mycobacterium ulcerans Agy99 hypothetical protein YP_906176.1 2612273 D 362242 CDS YP_906177.1 118617845 4550480 2613578..2614546 1 NC_008611.1 membrane protein; integral membrane protein 2614546 4550480 MUL_2335 Mycobacterium ulcerans Agy99 integral membrane protein YP_906177.1 2613578 D 362242 CDS YP_906178.1 118617846 4550481 2614607..2615182 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2615182 4550481 MUL_2336 Mycobacterium ulcerans Agy99 hypothetical protein YP_906178.1 2614607 D 362242 CDS YP_906179.1 118617847 4550482 complement(2615204..2617033) 1 NC_008611.1 cytoplasmic protein; ATPase 2617033 4550482 MUL_2337 Mycobacterium ulcerans Agy99 ATPase YP_906179.1 2615204 R 362242 CDS YP_906180.1 118617848 4550450 2617331..2617990 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; lipoprotein, LppK 2617990 lppK 4550450 lppK Mycobacterium ulcerans Agy99 lipoprotein, LppK YP_906180.1 2617331 D 362242 CDS YP_906181.1 118617849 4550451 2617999..2618301 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2618301 4550451 MUL_2339 Mycobacterium ulcerans Agy99 hypothetical protein YP_906181.1 2617999 D 362242 CDS YP_906182.1 118617850 4550452 complement(2618093..2619157) 1 NC_008611.1 cytoplasmic protein; involved in transfer of methyl group (from S- adenosyl-L-methionine to a substrate); RNA methyltransferase 2619157 4550452 MUL_2340 Mycobacterium ulcerans Agy99 RNA methyltransferase YP_906182.1 2618093 R 362242 CDS YP_906183.1 118617851 4550453 2619231..2620112 1 NC_008611.1 cytoplasmic protein; has significant domain identity to RecB family exonucleases; hypothetical protein 2620112 4550453 MUL_2341 Mycobacterium ulcerans Agy99 hypothetical protein YP_906183.1 2619231 D 362242 CDS YP_906184.1 118617852 4550454 2620109..2620888 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2620888 4550454 MUL_2342 Mycobacterium ulcerans Agy99 hypothetical protein YP_906184.1 2620109 D 362242 CDS YP_906185.1 118617853 4550456 2621540..2622586 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 2622586 4550456 MUL_2344 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_906185.1 2621540 D 362242 CDS YP_906186.1 118617854 4550457 complement(2626438..2627772) 1 NC_008611.1 cytoplasmic protein; required for the transposition of the insertion element IS2606; transposase for IS2606 2627772 4550457 MUL_2347 Mycobacterium ulcerans Agy99 transposase for IS2606 YP_906186.1 2626438 R 362242 CDS YP_906187.1 118617855 4550460 2636142..2637476 1 NC_008611.1 cytoplasmic protein; required for the transposition of the insertion element IS2606.; transposase for IS2606 2637476 4550460 MUL_2350 Mycobacterium ulcerans Agy99 transposase for IS2606 YP_906187.1 2636142 D 362242 CDS YP_906188.1 118617856 4550461 2637929..2638975 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 2638975 4550461 MUL_2351 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_906188.1 2637929 D 362242 CDS YP_906189.1 118617857 4550462 complement(2639255..2640115) 1 NC_008611.1 long form of enzyme; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms active dimers and inactive hexamers which is dependent on concentration of substrates and inhibitors; ATP phosphoribosyltransferase 2640115 hisG 4550462 hisG Mycobacterium ulcerans Agy99 ATP phosphoribosyltransferase YP_906189.1 2639255 R 362242 CDS YP_906190.1 118617858 4550463 complement(2640112..2640393) 1 NC_008611.1 catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribolsyl)-ATP in histidine biosynthesis; phosphoribosyl-ATP pyrophosphatase 2640393 hisE 4550463 hisE Mycobacterium ulcerans Agy99 phosphoribosyl-ATP pyrophosphatase YP_906190.1 2640112 R 362242 CDS YP_906191.1 118617859 4550464 complement(2640512..2642440) 1 NC_008611.1 membrane protein; PE-PGRS family protein 2642440 4550464 MUL_2354 Mycobacterium ulcerans Agy99 PE-PGRS family protein YP_906191.1 2640512 R 362242 CDS YP_906192.1 118617860 4550433 2644847..2645725 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2645725 4550433 MUL_2357 Mycobacterium ulcerans Agy99 hypothetical protein YP_906192.1 2644847 D 362242 CDS YP_906193.1 118617861 4550434 complement(2645863..2646984) 1 NC_008611.1 membrane protein; function unknown, probably involved in cellular metabolism.; FAD-dependent oxidoreductase 2646984 4550434 MUL_2358 Mycobacterium ulcerans Agy99 FAD-dependent oxidoreductase YP_906193.1 2645863 R 362242 CDS YP_906194.1 118617862 4550435 complement(2647018..2647899) 1 NC_008611.1 cytoplasmic protein; short chain dehydrogenase 2647899 4550435 MUL_2359 Mycobacterium ulcerans Agy99 short chain dehydrogenase YP_906194.1 2647018 R 362242 CDS YP_906195.1 118617863 4550436 complement(2647923..2649158) 1 NC_008611.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA; cysteinyl-tRNA synthetase 2649158 mshC 4550436 mshC Mycobacterium ulcerans Agy99 cysteinyl-tRNA synthetase YP_906195.1 2647923 R 362242 CDS YP_906196.1 118617864 4550437 2649428..2651044 1 NC_008611.1 cytoplasmic protein; involved in 4-aminobutyrate (GabA) degradation pathway [catalytic activity: succinate semialdehyde + NAD(P)(+) + H(2)O = succinate + NAD(P)H]; succinate-semialdehyde dehydrogenase [NADP+] dependent, GabD1_1 2651044 gabD1_1 4550437 gabD1_1 Mycobacterium ulcerans Agy99 succinate-semialdehyde dehydrogenase [NADP+] dependent, GabD1_1 YP_906196.1 2649428 D 362242 CDS YP_906197.1 118617865 4550438 complement(2651073..2651864) 1 NC_008611.1 cytoplasmic protein; may help control the pool of 3'-phosphoadenoside 5'- phosphosulfate, or its use in sulfite synthesis (by similarity); monophosphatase CysQ 2651864 cysQ 4550438 cysQ Mycobacterium ulcerans Agy99 monophosphatase CysQ YP_906197.1 2651073 R 362242 CDS YP_906198.1 118617866 4550439 complement(2651976..2652761) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2652761 4550439 MUL_2363 Mycobacterium ulcerans Agy99 hypothetical protein YP_906198.1 2651976 R 362242 CDS YP_906199.1 118617867 4550440 complement(2652775..2653362) 1 NC_008611.1 Detected in the cytoplasmic and secreted fractions by 2D-LC-MS/MS.; cytoplasmic protein; hypothetical protein 2653362 4550440 MUL_2364 Mycobacterium ulcerans Agy99 hypothetical protein YP_906199.1 2652775 R 362242 CDS YP_906200.1 118617868 4550441 complement(2653451..2654197) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2654197 4550441 MUL_2365 Mycobacterium ulcerans Agy99 hypothetical protein YP_906200.1 2653451 R 362242 CDS YP_906201.1 118617869 4550442 complement(2654194..2655024) 1 NC_008611.1 BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell; undecaprenyl pyrophosphate phosphatase 2655024 4550442 MUL_2366 Mycobacterium ulcerans Agy99 undecaprenyl pyrophosphate phosphatase YP_906201.1 2654194 R 362242 CDS YP_906202.1 118617870 4550443 complement(2655073..2655453) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2655453 4550443 MUL_2367 Mycobacterium ulcerans Agy99 hypothetical protein YP_906202.1 2655073 R 362242 CDS YP_906203.1 118617871 4550444 2655513..2656583 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; lipoprotein LppL 2656583 lppL 4550444 lppL Mycobacterium ulcerans Agy99 lipoprotein LppL YP_906203.1 2655513 D 362242 CDS YP_906204.1 118617872 4550445 2656580..2656843 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2656843 4550445 MUL_2369 Mycobacterium ulcerans Agy99 hypothetical protein YP_906204.1 2656580 D 362242 CDS YP_906205.1 118617873 4550446 2656876..2657958 1 NC_008611.1 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors; dihydroorotate dehydrogenase 2 2657958 pyrD 4550446 pyrD Mycobacterium ulcerans Agy99 dihydroorotate dehydrogenase 2 YP_906205.1 2656876 D 362242 CDS YP_906206.1 118617874 4550447 complement(2657970..2659358) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2659358 4550447 MUL_2371 Mycobacterium ulcerans Agy99 hypothetical protein YP_906206.1 2657970 R 362242 CDS YP_906207.1 118617875 4550448 complement(2659485..2660012) 1 NC_008611.1 Also detected in the extracellular matrix by proteomics.; cytoplasmic protein; function unknown but contains bacterial/archael phosphatidylethanolamine-binding (PEBP) domain; hypothetical protein 2660012 4550448 MUL_2372 Mycobacterium ulcerans Agy99 hypothetical protein YP_906207.1 2659485 R 362242 CDS YP_906208.1 118617876 4550449 complement(2660039..2661394) 1 NC_008611.1 Also detected in the membrane fraction by proteomics (2D-LC-MS/MS); cytoplasmic protein; function unknown - but has domain identity with cetylornithine deacetylase/succinyl-diaminopimelate desuccinylase and related deacylases [amino acid transport and metabolism]; hypothetical protein 2661394 4550449 MUL_2373 Mycobacterium ulcerans Agy99 hypothetical protein YP_906208.1 2660039 R 362242 CDS YP_906209.1 118617877 4550416 2662592..2663041 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2663041 4550416 MUL_2376 Mycobacterium ulcerans Agy99 hypothetical protein YP_906209.1 2662592 D 362242 CDS YP_906210.1 118617878 4550417 complement(2662972..2663787) 1 NC_008611.1 cytoplasmic protein; orthologue in M. tuberculosis H37Rv has been shown to catalyze the transfer of a methyl group onto the lipid moiety of phthiotriol dimycocerosates to form DIM.; methyltransferase 2663787 4550417 MUL_2377 Mycobacterium ulcerans Agy99 methyltransferase YP_906210.1 2662972 R 362242 CDS YP_906211.1 118617879 4550419 complement(2664299..2664529) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2664529 4550419 MUL_2379 Mycobacterium ulcerans Agy99 hypothetical protein YP_906211.1 2664299 R 362242 CDS YP_906212.1 118617880 4550421 complement(2665397..2665627) 1 NC_008611.1 cytoplasmic protein; thought to be involved in the biogenesis of the hydroxyphenyloxazoline-containing siderophore mycobactins.; protein MbtH 2665627 mbtH 4550421 mbtH Mycobacterium ulcerans Agy99 protein MbtH YP_906212.1 2665397 R 362242 CDS YP_906213.1 118617881 4550423 complement(2668786..2669256) 1 NC_008611.1 membrane protein; membrane protein MmpS4 2669256 mmpS4 4550423 mmpS4 Mycobacterium ulcerans Agy99 membrane protein MmpS4 YP_906213.1 2668786 R 362242 CDS YP_906214.1 118617882 4550424 2669561..2670607 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 2670607 4550424 MUL_2384 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_906214.1 2669561 D 362242 CDS YP_906215.1 118617883 4550426 2671459..2671980 1 NC_008611.1 Detected in the membrane fraction by proteomics.; secreted protein; hypothetical protein 2671980 4550426 MUL_2386 Mycobacterium ulcerans Agy99 hypothetical protein YP_906215.1 2671459 D 362242 CDS YP_906216.1 118617884 4550427 complement(2672027..2672707) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2672707 4550427 MUL_2387 Mycobacterium ulcerans Agy99 hypothetical protein YP_906216.1 2672027 R 362242 CDS YP_906217.1 118617885 4550428 2672923..2673540 1 NC_008611.1 hypothetical protein 2673540 4550428 MUL_2388 Mycobacterium ulcerans Agy99 hypothetical protein YP_906217.1 2672923 D 362242 CDS YP_906218.1 118617886 4550429 2673544..2674269 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; hypothetical protein 2674269 4550429 MUL_2389 Mycobacterium ulcerans Agy99 hypothetical protein YP_906218.1 2673544 D 362242 CDS YP_906219.1 118617887 4550430 2674336..2675202 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2675202 4550430 MUL_2390 Mycobacterium ulcerans Agy99 hypothetical protein YP_906219.1 2674336 D 362242 CDS YP_906220.1 118617888 4550367 complement(2675246..2675947) 1 NC_008611.1 membrane protein; hypothetical protein 2675947 4550367 MUL_2391 Mycobacterium ulcerans Agy99 hypothetical protein YP_906220.1 2675246 R 362242 CDS YP_906221.1 118617889 4550368 2676195..2676458 1 NC_008611.1 membrane protein; hypothetical protein 2676458 4550368 MUL_2392 Mycobacterium ulcerans Agy99 hypothetical protein YP_906221.1 2676195 D 362242 CDS YP_906222.1 118617890 4550369 complement(2676498..2676851) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2676851 4550369 MUL_2393 Mycobacterium ulcerans Agy99 hypothetical protein YP_906222.1 2676498 R 362242 CDS YP_906223.1 118617891 4550370 2676950..2677177 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2677177 4550370 MUL_2394 Mycobacterium ulcerans Agy99 hypothetical protein YP_906223.1 2676950 D 362242 CDS YP_906224.1 118617892 4550371 2677467..2678669 1 NC_008611.1 PE26; membrane protein; PE family protein 2678669 4550371 MUL_2395 Mycobacterium ulcerans Agy99 PE family protein YP_906224.1 2677467 D 362242 CDS YP_906225.1 118617893 4550373 complement(2679184..2680029) 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS. Also detected in the membrane fraction by proteomics.; cytoplasmic protein; hypothetical protein 2680029 4550373 MUL_2397 Mycobacterium ulcerans Agy99 hypothetical protein YP_906225.1 2679184 R 362242 CDS YP_906226.1 118617894 4550374 complement(2680007..2681086) 1 NC_008611.1 membrane protein; hypothetical protein 2681086 4550374 MUL_2398 Mycobacterium ulcerans Agy99 hypothetical protein YP_906226.1 2680007 R 362242 CDS YP_906227.1 118617895 4550375 complement(2681083..2682324) 1 NC_008611.1 membrane protein; ATPase; possibly catalyzes the transport of undeterminated substrate with hydrolysis of ATP [catalytic activity: ATP + H(2)O + undeterminated substrate(in) = ADP + phosphate + undeterminated substrate(out)]; ATPase 2682324 4550375 MUL_2399 Mycobacterium ulcerans Agy99 ATPase YP_906227.1 2681083 R 362242 CDS YP_906228.1 118617896 4550377 complement(2684249..2685295) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 2685295 4550377 MUL_2401 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_906228.1 2684249 R 362242 CDS YP_906229.1 118617897 4550379 2687010..2688341 1 NC_008611.1 cytoplasmic protein; required for the transposition of the insertion element IS2606; transposase for IS2606 2688341 4550379 MUL_2404 Mycobacterium ulcerans Agy99 transposase for IS2606 YP_906229.1 2687010 D 362242 CDS YP_906230.1 118617898 4550380 complement(2688390..2689436) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 2689436 4550380 MUL_2405 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_906230.1 2688390 R 362242 CDS YP_906231.1 118617899 4550381 complement(2690078..2690584) 1 NC_008611.1 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation; SsrA-binding protein 2690584 smpB 4550381 smpB Mycobacterium ulcerans Agy99 SsrA-binding protein YP_906231.1 2690078 R 362242 CDS YP_906232.1 118617900 4550382 complement(2690587..2691480) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; involved in growth (principally during log phase cells) thought to be involved in active transport of septation component across the membrane. responsible for the translocation of the substrate across the membrane. coded for in an operon essential for ce; cell division protein FtsX 2691480 ftsX 4550382 ftsX Mycobacterium ulcerans Agy99 cell division protein FtsX YP_906232.1 2690587 R 362242 CDS YP_906233.1 118617901 4550350 complement(2691481..2692170) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; involved in growth. thought to be involved in active transport of septation component across the membrane. responsible for energy coupling to the transport system. coded for in an operon essential for cell division.; cell division ATP-binding protein FtsE 2692170 ftsE 4550350 ftsE Mycobacterium ulcerans Agy99 cell division ATP-binding protein FtsE YP_906233.1 2691481 R 362242 CDS YP_906234.1 118617902 4550351 complement(2692215..2692715) 1 NC_008611.1 membrane protein; function unknown: predicted solute binding protein; hypothetical protein 2692715 4550351 MUL_2410 Mycobacterium ulcerans Agy99 hypothetical protein YP_906234.1 2692215 R 362242 CDS YP_906235.1 118617903 4550352 complement(2692718..2693704) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; function unknown but contains mechanosensitive (ms) ion channel forming domain with a possible role in cell envelope biogenesis.; transmembrane protein 2693704 4550352 MUL_2411 Mycobacterium ulcerans Agy99 transmembrane protein YP_906235.1 2692718 R 362242 CDS YP_906236.1 118617904 4550353 complement(2693694..2694809) 1 NC_008611.1 recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2; in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism; this protein is similar to release factor 1; peptide chain release factor 2 2694809 prfB 4550353 prfB Mycobacterium ulcerans Agy99 peptide chain release factor 2 YP_906236.1 2693694 R 362242 CDS YP_906237.1 118617905 4550354 2694868..2696313 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS. Also detected in the membrane fraction by proteomics.; cytoplasmic protein; generates oxidized ferredoxin from ferredoxin [catalytic activity: reduced ferredoxin + NADP(+) = oxidized ferredoxin + NADPH]; NADPH:adrenodoxin oxidoreductase FprA_1 2696313 fprA_1 4550354 fprA_1 Mycobacterium ulcerans Agy99 NADPH:adrenodoxin oxidoreductase FprA_1 YP_906237.1 2694868 D 362242 CDS YP_906238.1 118617906 4550355 2696898..2697944 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 2697944 4550355 MUL_2414 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_906238.1 2696898 D 362242 CDS YP_906239.1 118617907 4550357 complement(2699261..2700865) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2700865 4550357 MUL_2416 Mycobacterium ulcerans Agy99 hypothetical protein YP_906239.1 2699261 R 362242 CDS YP_906240.1 118617908 4550358 2701011..2702018 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2702018 4550358 MUL_2417 Mycobacterium ulcerans Agy99 hypothetical protein YP_906240.1 2701011 D 362242 CDS YP_906241.1 118617909 4550359 2702023..2702451 1 NC_008611.1 Also detected in the extracellular matrix and the membrane fraction by proteomics.; cytoplasmic protein; hypothetical protein 2702451 4550359 MUL_2418 Mycobacterium ulcerans Agy99 hypothetical protein YP_906241.1 2702023 D 362242 CDS YP_906242.1 118617910 4550360 complement(2702536..2702958) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2702958 4550360 MUL_2419 Mycobacterium ulcerans Agy99 hypothetical protein YP_906242.1 2702536 R 362242 CDS YP_906243.1 118617911 4550361 complement(2702955..2704343) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2704343 4550361 MUL_2420 Mycobacterium ulcerans Agy99 hypothetical protein YP_906243.1 2702955 R 362242 CDS YP_906244.1 118617912 4550362 2704487..2705533 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2705533 4550362 MUL_2421 Mycobacterium ulcerans Agy99 hypothetical protein YP_906244.1 2704487 D 362242 CDS YP_906245.1 118617913 4550363 complement(2705513..2707270) 1 NC_008611.1 membrane protein; sensor part of the two component regulatory system DevR/DevS. thought to control HspX|Acr expression.; two component sensor histidine kinase DevS 2707270 devS 4550363 devS Mycobacterium ulcerans Agy99 two component sensor histidine kinase DevS YP_906245.1 2705513 R 362242 CDS YP_906246.1 118617914 4550364 complement(2707282..2707932) 1 NC_008611.1 cytoplasmic protein; regulator part of the two component regulatory system DevR/DevS. controls HspX|Acr expression.; two component transcriptional regulatory protein DevR 2707932 devR 4550364 devR Mycobacterium ulcerans Agy99 two component transcriptional regulatory protein DevR YP_906246.1 2707282 R 362242 CDS YP_906247.1 118617915 4550365 complement(2707956..2708750) 1 NC_008611.1 membrane protein; may play a role in the adaptation to hypoxia, participating in the phosphorelay in the two component regulatory system DevR/DevS; hypothetical protein 2708750 4550365 MUL_2424 Mycobacterium ulcerans Agy99 hypothetical protein YP_906247.1 2707956 R 362242 CDS YP_906248.1 118617916 4550366 complement(2708926..2710260) 1 NC_008611.1 cytoplasmic protein; required for the transposition of the insertion element IS2606; transposase for IS2606 2710260 4550366 MUL_2425 Mycobacterium ulcerans Agy99 transposase for IS2606 YP_906248.1 2708926 R 362242 CDS YP_906249.1 118617917 4550333 complement(2710381..2711427) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 2711427 4550333 MUL_2426 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_906249.1 2710381 R 362242 CDS YP_906250.1 118617918 4550334 2712510..2713655 1 NC_008611.1 Detected in the membrane fraction by proteomics (2D- LC-MS/MS); membrane protein; PPE family protein 2713655 4550334 MUL_2427 Mycobacterium ulcerans Agy99 PPE family protein YP_906250.1 2712510 D 362242 CDS YP_906251.1 118617919 4550335 2714196..2715344 1 NC_008611.1 PPE51; membrane protein; PPE family protein 2715344 4550335 MUL_2428 Mycobacterium ulcerans Agy99 PPE family protein YP_906251.1 2714196 D 362242 CDS YP_906252.1 118617920 4550336 complement(2715363..2715698) 1 NC_008611.1 membrane protein; hypothetical protein 2715698 4550336 MUL_2429 Mycobacterium ulcerans Agy99 hypothetical protein YP_906252.1 2715363 R 362242 CDS YP_906253.1 118617921 4550337 2715722..2716510 1 NC_008611.1 cytoplasmic protein; function unknown, involved in cellular metabolism.; monophosphatase 2716510 4550337 MUL_2430 Mycobacterium ulcerans Agy99 monophosphatase YP_906253.1 2715722 D 362242 CDS YP_906254.1 118617922 4550338 2716592..2717989 1 NC_008611.1 cytoplasmic protein; function unknown, but involved in lipid degradation.; acyl-CoA dehydrogenase FadE24 2717989 fadE24 4550338 fadE24 Mycobacterium ulcerans Agy99 acyl-CoA dehydrogenase FadE24 YP_906254.1 2716592 D 362242 CDS YP_906255.1 118617923 4550339 2718044..2719249 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; function unknown, but involved in lipid degradation.; acyl-CoA dehydrogenase FadE23 2719249 fadE23 4550339 fadE23 Mycobacterium ulcerans Agy99 acyl-CoA dehydrogenase FadE23 YP_906255.1 2718044 D 362242 CDS YP_906256.1 118617924 4550340 complement(2719259..2720935) 1 NC_008611.1 catalyzes the formation of 2-acetolactate from pyruvate in stationary phase; acetolactate synthase 2720935 ilvB1_1 4550340 ilvB1_1 Mycobacterium ulcerans Agy99 acetolactate synthase YP_906256.1 2719259 R 362242 CDS YP_906257.1 118617925 4550341 complement(2720932..2721708) 1 NC_008611.1 cytoplasmic protein; function unknown, possible role secondary metabolite biosynthesis; alpha-acetolactate decarboxylase 2721708 4550341 MUL_2434 Mycobacterium ulcerans Agy99 alpha-acetolactate decarboxylase YP_906257.1 2720932 R 362242 CDS YP_906258.1 118617926 4550342 complement(2721757..2722791) 1 NC_008611.1 catalyzes the formation of pyruvate and acetaldehyde from 4-hydroxy-2-ketovaleric acid; involved in the degradation of phenylpropionate; 4-hydroxy-2-ketovalerate aldolase 2722791 4550342 MUL_2435 Mycobacterium ulcerans Agy99 4-hydroxy-2-ketovalerate aldolase YP_906258.1 2721757 R 362242 CDS YP_906259.2 162138269 4550343 complement(2722788..2723735) 1 NC_008611.1 catalyzes the formation of acetyl-CoA from acetalaldehyde; acetaldehyde dehydrogenase 2723735 mhpF 4550343 mhpF Mycobacterium ulcerans Agy99 acetaldehyde dehydrogenase YP_906259.2 2722788 R 362242 CDS YP_906260.1 118617928 4550344 2724109..2725344 1 NC_008611.1 Potential extended N-term caused by an u/s DNA deletion and point mutation that has created a fusion of MON6244 and MON2437; membrane protein; hypothetical protein 2725344 4550344 MUL_2437 Mycobacterium ulcerans Agy99 hypothetical protein YP_906260.1 2724109 D 362242 CDS YP_906261.1 118617929 4550345 2725412..2726410 1 NC_008611.1 cytoplasmic protein; function unknown, probably involved in cellular metabolism.; oxidoreductase 2726410 4550345 MUL_2438 Mycobacterium ulcerans Agy99 oxidoreductase YP_906261.1 2725412 D 362242 CDS YP_906262.1 118617930 4550346 2726453..2727424 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; involved in lipid degradation [catalytic activity: NADPH + quinone = NADP(+) + semiquinone]; NADPH quinone oxidoreductase FadB4 2727424 fadB4 4550346 fadB4 Mycobacterium ulcerans Agy99 NADPH quinone oxidoreductase FadB4 YP_906262.1 2726453 D 362242 CDS YP_906263.1 118617931 4550347 complement(2727442..2729355) 1 NC_008611.1 PPE28; membrane protein; PPE family protein 2729355 4550347 MUL_2440 Mycobacterium ulcerans Agy99 PPE family protein YP_906263.1 2727442 R 362242 CDS YP_906264.1 118617932 4550348 2729451..2730785 1 NC_008611.1 cytoplasmic protein; required for the transposition of the insertion element IS2606.; transposase for IS2606 2730785 4550348 MUL_2441 Mycobacterium ulcerans Agy99 transposase for IS2606 YP_906264.1 2729451 D 362242 CDS YP_906265.1 118617933 4550349 complement(2730856..2731902) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 2731902 4550349 MUL_2442 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_906265.1 2730856 R 362242 CDS YP_906266.1 118617934 4550315 2732267..2733412 1 NC_008611.1 cytoplasmic protein; oxidoreductase 2733412 4550315 MUL_2443 Mycobacterium ulcerans Agy99 oxidoreductase YP_906266.1 2732267 D 362242 CDS YP_906267.1 118617935 4550317 2734612..2735817 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; hypothetical protein 2735817 4550317 MUL_2446 Mycobacterium ulcerans Agy99 hypothetical protein YP_906267.1 2734612 D 362242 CDS YP_906268.1 118617936 4550318 2735814..2736710 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2736710 4550318 MUL_2447 Mycobacterium ulcerans Agy99 hypothetical protein YP_906268.1 2735814 D 362242 CDS YP_906269.1 118617937 4550319 2736710..2737351 1 NC_008611.1 cytoplasmic protein; involved in transcriptional mechanism.; transcriptional regulatory protein 2737351 4550319 MUL_2448 Mycobacterium ulcerans Agy99 transcriptional regulatory protein YP_906269.1 2736710 D 362242 CDS YP_906270.1 118617938 4550321 2738611..2739573 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2739573 4550321 MUL_2450 Mycobacterium ulcerans Agy99 hypothetical protein YP_906270.1 2738611 D 362242 CDS YP_906271.1 118617939 4550322 2739573..2739914 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2739914 4550322 MUL_5092 Mycobacterium ulcerans Agy99 hypothetical protein YP_906271.1 2739573 D 362242 CDS YP_906272.1 118617940 4550323 2739926..2740336 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2740336 4550323 MUL_2451 Mycobacterium ulcerans Agy99 hypothetical protein YP_906272.1 2739926 D 362242 CDS YP_906273.1 118617941 4550324 2740372..2740911 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; hypothetical protein 2740911 4550324 MUL_2452 Mycobacterium ulcerans Agy99 hypothetical protein YP_906273.1 2740372 D 362242 CDS YP_906274.1 118617942 4550325 2740986..2741387 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS; cytoplasmic protein; two-component system response regulator 2741387 4550325 MUL_2453 Mycobacterium ulcerans Agy99 two-component system response regulator YP_906274.1 2740986 D 362242 CDS YP_906275.1 118617943 4550327 complement(2742334..2743380) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 2743380 4550327 MUL_2455 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_906275.1 2742334 R 362242 CDS YP_906276.1 118617944 4550329 2746024..2746728 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; N-term transposase for IS2404 2746728 4550329 MUL_2457 Mycobacterium ulcerans Agy99 N-term transposase for IS2404 YP_906276.1 2746024 D 362242 CDS YP_906277.1 118617945 4550330 2746753..2747070 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; C-term transposase for IS2404 2747070 4550330 MUL_2458 Mycobacterium ulcerans Agy99 C-term transposase for IS2404 YP_906277.1 2746753 D 362242 CDS YP_906278.1 118617946 4550331 2747699..2748082 1 NC_008611.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit A 2748082 nuoA 4550331 nuoA Mycobacterium ulcerans Agy99 NADH dehydrogenase subunit A YP_906278.1 2747699 D 362242 CDS YP_906279.1 118617947 4550332 2748091..2748645 1 NC_008611.1 The point of entry for the majority of electrons that traverse the respiratory chain eventually resulting in the reduction of oxygen; NADH dehydrogenase subunit B 2748645 nuoB 4550332 nuoB Mycobacterium ulcerans Agy99 NADH dehydrogenase subunit B YP_906279.1 2748091 D 362242 CDS YP_906280.1 118617948 4550298 2748642..2749358 1 NC_008611.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit C 2749358 nuoC 4550298 nuoC Mycobacterium ulcerans Agy99 NADH dehydrogenase subunit C YP_906280.1 2748642 D 362242 CDS YP_906281.1 118617949 4550299 2749378..2750676 1 NC_008611.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit D 2750676 nuoD 4550299 nuoD Mycobacterium ulcerans Agy99 NADH dehydrogenase subunit D YP_906281.1 2749378 D 362242 CDS YP_906282.1 118617950 4550300 2750673..2751428 1 NC_008611.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit E 2751428 nuoE 4550300 nuoE Mycobacterium ulcerans Agy99 NADH dehydrogenase subunit E YP_906282.1 2750673 D 362242 CDS YP_906283.1 118617951 4550301 2751428..2752774 1 NC_008611.1 Detected in the membrane fraction by proteomics (2D- LC-MS/MS); involved in aerobic|anaerobic respiration [catalytic activity: NADH + ubiquinone = NAD(+) + ubiquinol]; NADH dehydrogenase I (chain F) NuoF (NADH- ubiquinone oxidoreductase chain F) 2752774 nuoF 4550301 nuoF Mycobacterium ulcerans Agy99 NADH dehydrogenase I (chain F) NuoF (NADH- ubiquinone oxidoreductase chain F) YP_906283.1 2751428 D 362242 CDS YP_906284.1 118617952 4550302 2752771..2755188 1 NC_008611.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit G 2755188 nuoG 4550302 nuoG Mycobacterium ulcerans Agy99 NADH dehydrogenase subunit G YP_906284.1 2752771 D 362242 CDS YP_906285.1 118617953 4550303 2755238..2756512 1 NC_008611.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit H 2756512 nuoH 4550303 nuoH Mycobacterium ulcerans Agy99 NADH dehydrogenase subunit H YP_906285.1 2755238 D 362242 CDS YP_906286.1 118617954 4550304 2756505..2757050 1 NC_008611.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit I 2757050 nuoI 4550304 nuoI Mycobacterium ulcerans Agy99 NADH dehydrogenase subunit I YP_906286.1 2756505 D 362242 CDS YP_906287.1 118617955 4550305 2757047..2757835 1 NC_008611.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit J 2757835 nuoJ 4550305 nuoJ Mycobacterium ulcerans Agy99 NADH dehydrogenase subunit J YP_906287.1 2757047 D 362242 CDS YP_906288.1 118617956 4550306 2757832..2758131 1 NC_008611.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit K 2758131 nuoK 4550306 nuoK Mycobacterium ulcerans Agy99 NADH dehydrogenase subunit K YP_906288.1 2757832 D 362242 CDS YP_906289.1 118617957 4550307 2758142..2760043 1 NC_008611.1 Catalyzes the transfer of electrons from NADH to ubiquinone; NADH dehydrogenase subunit L 2760043 nuoL 4550307 nuoL Mycobacterium ulcerans Agy99 NADH dehydrogenase subunit L YP_906289.1 2758142 D 362242 CDS YP_906290.1 118617958 4550308 2760037..2761626 1 NC_008611.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit M 2761626 nuoM 4550308 nuoM Mycobacterium ulcerans Agy99 NADH dehydrogenase subunit M YP_906290.1 2760037 D 362242 CDS YP_906291.1 118617959 4550309 2761623..2763209 1 NC_008611.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit N 2763209 nuoN 4550309 nuoN Mycobacterium ulcerans Agy99 NADH dehydrogenase subunit N YP_906291.1 2761623 D 362242 CDS YP_906292.1 118617960 4550311 2764120..2765166 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 2765166 4550311 MUL_2474 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_906292.1 2764120 D 362242 CDS YP_906293.1 118617961 4550312 complement(2766481..2766930) 1 NC_008611.1 membrane protein; hypothetical protein 2766930 4550312 MUL_2475 Mycobacterium ulcerans Agy99 hypothetical protein YP_906293.1 2766481 R 362242 CDS YP_906294.1 118617962 4550313 complement(2766932..2768209) 1 NC_008611.1 membrane protein; hypothetical protein 2768209 4550313 MUL_2476 Mycobacterium ulcerans Agy99 hypothetical protein YP_906294.1 2766932 R 362242 CDS YP_906295.1 118617963 4550314 complement(2768223..2769191) 1 NC_008611.1 cytoplasmic protein; involved in transcriptional mechanism; regulates methanol dehydrogenase.; methanol dehydrogenase transcriptional regulatory protein MoxR3 2769191 moxR3 4550314 moxR3 Mycobacterium ulcerans Agy99 methanol dehydrogenase transcriptional regulatory protein MoxR3 YP_906295.1 2768223 R 362242 CDS YP_906296.1 118617964 4550261 complement(2769717..2770697) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2770697 4550261 MUL_2480 Mycobacterium ulcerans Agy99 hypothetical protein YP_906296.1 2769717 R 362242 CDS YP_906297.1 118617965 4550262 complement(2770814..2771575) 1 NC_008611.1 cytoplasmic protein; function unknown, possibly involved in cellular metabolism.; short-chain type dehydrogenase/reductase 2771575 4550262 MUL_2481 Mycobacterium ulcerans Agy99 short-chain type dehydrogenase/reductase YP_906297.1 2770814 R 362242 CDS YP_906298.1 118617966 4550263 complement(2771677..2772279) 1 NC_008611.1 cytoplasmic protein; involved in transcriptional mechanism.; TetR family transcriptional regulator 2772279 4550263 MUL_2482 Mycobacterium ulcerans Agy99 TetR family transcriptional regulator YP_906298.1 2771677 R 362242 CDS YP_906299.1 118617967 4550264 2772324..2773460 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2773460 4550264 MUL_2483 Mycobacterium ulcerans Agy99 hypothetical protein YP_906299.1 2772324 D 362242 CDS YP_906300.1 118617968 4550265 2773460..2774584 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2774584 4550265 MUL_2484 Mycobacterium ulcerans Agy99 hypothetical protein YP_906300.1 2773460 D 362242 CDS YP_906301.1 118617969 4550266 2774738..2776912 1 NC_008611.1 PE_PGRS9; membrane protein; PE-PGRS family protein 2776912 4550266 MUL_2485 Mycobacterium ulcerans Agy99 PE-PGRS family protein YP_906301.1 2774738 D 362242 CDS YP_906302.1 118617970 4550267 complement(2776974..2777972) 1 NC_008611.1 cytoplasmic protein; function unknown, probably involved in cellular metabolism.; oxidoreductase 2777972 4550267 MUL_2486 Mycobacterium ulcerans Agy99 oxidoreductase YP_906302.1 2776974 R 362242 CDS YP_906303.1 118617971 4550268 2778076..2779422 1 NC_008611.1 cytoplasmic protein; may catalyze the oxidative deamination: oxidize on primary amines, and perhaps on secondary and tertiary amines [catalytic activity: RCH(2)NH(2) + H(2)O + O(2) = RchO + NH(3) + H(2)O(2)] may have important function in metabolism. supposed involved; flavin-containing monoamine oxidase AofH (amine oxidase) 2779422 aofH 4550268 aofH Mycobacterium ulcerans Agy99 flavin-containing monoamine oxidase AofH (amine oxidase) YP_906303.1 2778076 D 362242 CDS YP_906304.1 118617972 4550269 complement(2779417..2780397) 1 NC_008611.1 cytoplasmic protein; supposed involved in detoxification reactions.; non-heme haloperoxidase Hpx 2780397 hpx 4550269 hpx Mycobacterium ulcerans Agy99 non-heme haloperoxidase Hpx YP_906304.1 2779417 R 362242 CDS YP_906305.1 118617973 4550270 2780638..2781948 1 NC_008611.1 cytoplasmic protein; possibly catalyzes the oxidative deamination: oxidize on primary amines, and perhaps on secondary and tertiary amines [catalytic activity: RCH(2)NH(2) + H(2)O + O(2) = RchO + NH(3) + H(2)O(2)]; monoamine oxidase 2781948 4550270 MUL_2489 Mycobacterium ulcerans Agy99 monoamine oxidase YP_906305.1 2780638 D 362242 CDS YP_906306.1 118617974 4550271 complement(2781959..2782363) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2782363 4550271 MUL_5120 Mycobacterium ulcerans Agy99 hypothetical protein YP_906306.1 2781959 R 362242 CDS YP_906307.1 118617975 4550272 complement(2782433..2782810) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2782810 4550272 MUL_2490 Mycobacterium ulcerans Agy99 hypothetical protein YP_906307.1 2782433 R 362242 CDS YP_906308.1 118617976 4550273 complement(2782951..2783592) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2783592 4550273 MUL_2491 Mycobacterium ulcerans Agy99 hypothetical protein YP_906308.1 2782951 R 362242 CDS YP_906309.1 118617977 4550274 complement(2783690..2783923) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2783923 4550274 MUL_5082 Mycobacterium ulcerans Agy99 hypothetical protein YP_906309.1 2783690 R 362242 CDS YP_906310.1 118617978 4550275 complement(2784053..2784571) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2784571 4550275 MUL_2493 Mycobacterium ulcerans Agy99 hypothetical protein YP_906310.1 2784053 R 362242 CDS YP_906311.1 118617979 4550276 complement(2784932..2786065) 1 NC_008611.1 catalyzes the formation of citrate from acetyl-CoA and oxaloacetate; citrate synthase 2786065 gltA1 4550276 gltA1 Mycobacterium ulcerans Agy99 citrate synthase YP_906311.1 2784932 R 362242 CDS YP_906312.1 118617980 4550278 complement(2786978..2788567) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); cytoplasmic protein; hypothetical protein 2788567 4550278 MUL_2496 Mycobacterium ulcerans Agy99 hypothetical protein YP_906312.1 2786978 R 362242 CDS YP_906313.1 118617981 4550243 2788573..2790024 1 NC_008611.1 cytoplasmic protein; involved in transcriptional mechanism; transcriptional regulatory protein 2790024 4550243 MUL_2497 Mycobacterium ulcerans Agy99 transcriptional regulatory protein YP_906313.1 2788573 D 362242 CDS YP_906314.1 118617982 4550244 complement(2790075..2791010) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2791010 4550244 MUL_2498 Mycobacterium ulcerans Agy99 hypothetical protein YP_906314.1 2790075 R 362242 CDS YP_906315.1 118617983 4550245 complement(2791007..2791561) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2791561 4550245 MUL_2499 Mycobacterium ulcerans Agy99 hypothetical protein YP_906315.1 2791007 R 362242 CDS YP_906316.1 118617984 4550246 complement(2791573..2793708) 1 NC_008611.1 cytoplasmic protein; thought to play an important role in the mineralization of sulfates [catalytic activity: a phenol sulfate + H2O = a phenol + sulfate]; arylsulfatase AtsD_1 2793708 atsD_1 4550246 atsD_1 Mycobacterium ulcerans Agy99 arylsulfatase AtsD_1 YP_906316.1 2791573 R 362242 CDS YP_906317.1 118617985 4550247 complement(2794174..2794548) 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; function unknown, possible role in posttranslational modification, protein turnover, chaperonefunctions; FK-506 binding protein, peptidyl-prolyl cis- trans isomerase 2794548 4550247 MUL_2502 Mycobacterium ulcerans Agy99 FK-506 binding protein, peptidyl-prolyl cis- trans isomerase YP_906317.1 2794174 R 362242 CDS YP_906318.1 118617986 4550249 2795113..2796126 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2796126 4550249 MUL_2504 Mycobacterium ulcerans Agy99 hypothetical protein YP_906318.1 2795113 D 362242 CDS YP_906319.1 118617987 4550250 complement(2796271..2799258) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; hypothetical protein 2799258 4550250 MUL_2505 Mycobacterium ulcerans Agy99 hypothetical protein YP_906319.1 2796271 R 362242 CDS YP_906320.1 118617988 4550251 complement(2799380..2800402) 1 NC_008611.1 secreted protein; serine protease 2800402 4550251 MUL_2506 Mycobacterium ulcerans Agy99 serine protease YP_906320.1 2799380 R 362242 CDS YP_906321.1 118617989 4550252 2800481..2801899 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2801899 4550252 MUL_2507 Mycobacterium ulcerans Agy99 hypothetical protein YP_906321.1 2800481 D 362242 CDS YP_906322.1 118617990 4550253 2801938..2802777 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2802777 4550253 MUL_2508 Mycobacterium ulcerans Agy99 hypothetical protein YP_906322.1 2801938 D 362242 CDS YP_906323.1 118617991 4550254 complement(2802797..2803015) 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; hypothetical protein 2803015 4550254 MUL_2509 Mycobacterium ulcerans Agy99 hypothetical protein YP_906323.1 2802797 R 362242 CDS YP_906324.1 118617992 4550255 2803162..2804505 1 NC_008611.1 thought to be involved in active transport across the membrane. responsible for energy coupling to the transport system.; ABC transporter ATP-binding protein 2804505 4550255 MUL_2510 Mycobacterium ulcerans Agy99 ABC transporter ATP-binding protein YP_906324.1 2803162 D 362242 CDS YP_906325.1 118617993 4550256 complement(2804608..2804871) 1 NC_008611.1 cytoplasmic protein; involved in transcriptional mechanism.; transcriptional regulatory protein Whib-like WhiB7 2804871 whiB7 4550256 whiB7 Mycobacterium ulcerans Agy99 transcriptional regulatory protein Whib-like WhiB7 YP_906325.1 2804608 R 362242 CDS YP_906326.1 118617994 4550257 complement(2805302..2807401) 1 NC_008611.1 cytoplasmic protein; involved in nucleotide excision repair. has both ATPase and helicase activities. unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single- stranded region is present. involved in the postincision events of nucleotide excision repair and methyl-directed mismatch repair.; ATP-dependent DNA helicase II UvrD2 2807401 uvrD2 4550257 uvrD2 Mycobacterium ulcerans Agy99 ATP-dependent DNA helicase II UvrD2 YP_906326.1 2805302 R 362242 CDS YP_906327.1 118617995 4550258 2807557..2807811 1 NC_008611.1 cytoplasmic protein; glutaredoxin protein 2807811 4550258 MUL_2513 Mycobacterium ulcerans Agy99 glutaredoxin protein YP_906327.1 2807557 D 362242 CDS YP_906328.1 118617996 4550259 complement(2807777..2808823) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 2808823 4550259 MUL_2514 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_906328.1 2807777 R 362242 CDS YP_906329.1 118617997 4550155 2809234..2810622 1 NC_008611.1 cytoplasmic protein; required for the transposition of the insertion element IS2606.; transposase for IS2606 2810622 4550155 MUL_2515 Mycobacterium ulcerans Agy99 transposase for IS2606 YP_906329.1 2809234 D 362242 CDS YP_906330.1 118617998 4550156 complement(2810693..2811757) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 2811757 4550156 MUL_2516 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_906330.1 2810693 R 362242 CDS YP_906331.1 118617999 4550157 2812222..2813031 1 NC_008611.1 membrane protein; lipoprotein LpqQ 2813031 lpqQ 4550157 lpqQ Mycobacterium ulcerans Agy99 lipoprotein LpqQ YP_906331.1 2812222 D 362242 CDS YP_906332.1 118618000 4550158 complement(2813035..2813973) 1 NC_008611.1 can catalyze hydrolysis of broad range of dinucleotide pyrophosphates but prefers reduced form of NADH; requires divalent metal ions such as magnesium and manganese and produces two mononucleoside 5'-phosphates; NADH pyrophosphatase 2813973 nudC 4550158 nudC Mycobacterium ulcerans Agy99 NADH pyrophosphatase YP_906332.1 2813035 R 362242 CDS YP_906333.1 118618001 4550159 complement(2813963..2815141) 1 NC_008611.1 membrane protein; thought to be involved in cation transport across the membrane.; transmembrane cation transporter 2815141 4550159 MUL_2519 Mycobacterium ulcerans Agy99 transmembrane cation transporter YP_906333.1 2813963 R 362242 CDS YP_906334.1 118618002 4550160 complement(2815203..2818508) 1 NC_008611.1 Detected in the membrane fraction by proteomics.; membrane protein; has both ATPase and helicase activities; ATP-dependent DNA helicase 2818508 4550160 MUL_2520 Mycobacterium ulcerans Agy99 ATP-dependent DNA helicase YP_906334.1 2815203 R 362242 CDS YP_906335.1 118618003 4550161 complement(2818505..2821678) 1 NC_008611.1 membrane protein; has both ATPase and helicase activities; ATP-dependent DNA helicase 2821678 4550161 MUL_2521 Mycobacterium ulcerans Agy99 ATP-dependent DNA helicase YP_906335.1 2818505 R 362242 CDS YP_906336.1 118618004 4550162 complement(2821824..2822666) 1 NC_008611.1 membrane protein; hypothetical protein 2822666 4550162 MUL_2522 Mycobacterium ulcerans Agy99 hypothetical protein YP_906336.1 2821824 R 362242 CDS YP_906337.1 118618005 4550163 2822812..2823057 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2823057 4550163 MUL_2523 Mycobacterium ulcerans Agy99 hypothetical protein YP_906337.1 2822812 D 362242 CDS YP_906338.1 118618006 4550164 2823122..2823907 1 NC_008611.1 function unknown, presumed lipolytic enzyme involved in cellular metabolism.; lipase LipV 2823907 lipV 4550164 lipV Mycobacterium ulcerans Agy99 lipase LipV YP_906338.1 2823122 D 362242 CDS YP_906339.1 118618007 4550165 2823910..2824218 1 NC_008611.1 cytoplasmic protein; causes methylation of DNA.; DNA-methyltransferase (modification methylase) 2824218 4550165 MUL_2525 Mycobacterium ulcerans Agy99 DNA-methyltransferase (modification methylase) YP_906339.1 2823910 D 362242 CDS YP_906340.1 118618008 4550166 complement(2824215..2825129) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2825129 4550166 MUL_2526 Mycobacterium ulcerans Agy99 hypothetical protein YP_906340.1 2824215 R 362242 CDS YP_906341.1 118618009 4550167 complement(2825135..2826316) 1 NC_008611.1 The proteins in this cluster have high sequence similarity to MoeB and are possibly involved in the synthesis of molybdopterin, but there has been no biochemical or physiological characterization. There is also no genetic linkage to other molybdopterin cofactor synthesis proteins. These proteins are similar to a Pseudomonas stutzeri protein which is essential to pyridine-2,6-bis(thiocarboxylic acid) synthesis that possibly activates a substrate by adenylation; molybdopterin biosynthesis-like protein MoeZ 2826316 moeB1 4550167 moeB1 Mycobacterium ulcerans Agy99 molybdopterin biosynthesis-like protein MoeZ YP_906341.1 2825135 R 362242 CDS YP_906342.1 118618010 4550168 complement(2826488..2827471) 1 NC_008611.1 hypothetical protein 2827471 4550168 MUL_2528 Mycobacterium ulcerans Agy99 hypothetical protein YP_906342.1 2826488 R 362242 CDS YP_906343.1 118618011 4550169 2827699..2828382 1 NC_008611.1 cytoplasmic protein; involved in transcriptional mechanism.; TetR family transcriptional regulator 2828382 4550169 MUL_2529 Mycobacterium ulcerans Agy99 TetR family transcriptional regulator YP_906343.1 2827699 D 362242 CDS YP_906344.1 118618012 4550170 complement(2828379..2828624) 1 NC_008611.1 Detected in the cytoplamic fraction by LC-MS/MS. Also detected in the membrane fraction by proteomics (2D- LC-MS/MS); cytoplasmic protein; hypothetical protein 2828624 4550170 MUL_2530 Mycobacterium ulcerans Agy99 hypothetical protein YP_906344.1 2828379 R 362242 CDS YP_906345.1 118618013 4550171 2829066..2829620 1 NC_008611.1 membrane protein; putative threonine and proline rich protein 2829620 4550171 MUL_2531 Mycobacterium ulcerans Agy99 putative threonine and proline rich protein YP_906345.1 2829066 D 362242 CDS YP_906346.1 118618014 4550172 complement(2829633..2830328) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2830328 4550172 MUL_2532 Mycobacterium ulcerans Agy99 hypothetical protein YP_906346.1 2829633 R 362242 CDS YP_906347.1 118618015 4550061 2830591..2832144 1 NC_008611.1 cytoplasmic protein; has a helix-destabilizing activity; ATP-dependent RNA helicase RhlE 2832144 rhlE 4550061 rhlE Mycobacterium ulcerans Agy99 ATP-dependent RNA helicase RhlE YP_906347.1 2830591 D 362242 CDS YP_906348.1 118618016 4550062 2832159..2833373 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; hypothetical protein 2833373 4550062 MUL_2534 Mycobacterium ulcerans Agy99 hypothetical protein YP_906348.1 2832159 D 362242 CDS YP_906349.1 118618017 4550063 complement(2833396..2834196) 1 NC_008611.1 cytoplasmic protein; possibly involved in control of chromosome partitioning.; Soj/ParA-related protein 2834196 4550063 MUL_2535 Mycobacterium ulcerans Agy99 Soj/ParA-related protein YP_906349.1 2833396 R 362242 CDS YP_906350.1 118618018 4550064 2834198..2834872 1 NC_008611.1 forms a homodimer in Mycobacterium tuberculosis; belongs to the dPGM superfamily; acid phosphatase 2834872 gpm2 4550064 gpm2 Mycobacterium ulcerans Agy99 acid phosphatase YP_906350.1 2834198 D 362242 CDS YP_906351.1 118618019 4550065 2834869..2835969 1 NC_008611.1 cytoplasmic protein; could be involved in enterobactin biosynthesis. enterobactin is an iron-chelating compound involved in transporting iron from the bacterial environment into the cell cytoplasm. could be also involved in 2,3- dihydroxybenzoate or enterochelin or menaquinone biosynthesis [catalytic activity: chorismate = isochorismate]; isochorismate synthase EntC 2835969 entC 4550065 entC Mycobacterium ulcerans Agy99 isochorismate synthase EntC YP_906351.1 2834869 D 362242 CDS YP_906352.1 118618020 4550066 2835966..2836448 1 NC_008611.1 cytoplasmic protein; function unknown, involved in cellular metabolism.; acetyltransferase 2836448 4550066 MUL_2538 Mycobacterium ulcerans Agy99 acetyltransferase YP_906352.1 2835966 D 362242 CDS YP_906353.1 118618021 4550067 complement(2836400..2836831) 1 NC_008611.1 membrane protein; hypothetical protein 2836831 4550067 MUL_2539 Mycobacterium ulcerans Agy99 hypothetical protein YP_906353.1 2836400 R 362242 CDS YP_906354.1 118618022 4550068 2836956..2837921 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2837921 4550068 MUL_2540 Mycobacterium ulcerans Agy99 hypothetical protein YP_906354.1 2836956 D 362242 CDS YP_906355.1 118618023 4550069 2838205..2838459 1 NC_008611.1 cytoplasmic protein; involved in transcriptional mechanism.; transcriptional regulatory protein Whib-like WhiB1 2838459 whiB1 4550069 whiB1 Mycobacterium ulcerans Agy99 transcriptional regulatory protein Whib-like WhiB1 YP_906355.1 2838205 D 362242 CDS YP_906356.1 118618024 4550070 complement(2838522..2840021) 1 NC_008611.1 membrane protein; sensor part of a two component regulatory system.; sensor kinase from two component regulatory system 2840021 4550070 MUL_2542 Mycobacterium ulcerans Agy99 sensor kinase from two component regulatory system YP_906356.1 2838522 R 362242 CDS YP_906357.1 118618025 4550071 complement(2840071..2840535) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2840535 4550071 MUL_2543 Mycobacterium ulcerans Agy99 hypothetical protein YP_906357.1 2840071 R 362242 CDS YP_906358.1 118618026 4550072 complement(2840648..2840953) 1 NC_008611.1 cytoplasmic protein; binds sigma factor and inhibits it. probably involved in survival following heat shock and oxidative stress.; anti-sigma factor 2840953 4550072 MUL_2544 Mycobacterium ulcerans Agy99 anti-sigma factor YP_906358.1 2840648 R 362242 CDS YP_906359.1 118618027 4550073 complement(2840950..2841600) 1 NC_008611.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor is involved in heat shock and oxidative stress response; RNA polymerase sigma factor RpoE 2841600 sigH 4550073 sigH Mycobacterium ulcerans Agy99 RNA polymerase sigma factor RpoE YP_906359.1 2840950 R 362242 CDS YP_906360.1 118618028 4550074 2841917..2842765 1 NC_008611.1 Detected in the cytoplamic fraction by LC-MS/MS. Also detected in the membrane fraction by proteomics (2D- LC-MS/MS); cytoplasmic protein; function unknown, probably involved in cellular metabolism.; short chain dehydrogenase 2842765 4550074 MUL_2546 Mycobacterium ulcerans Agy99 short chain dehydrogenase YP_906360.1 2841917 D 362242 CDS YP_906361.1 118618029 4550075 2842901..2843236 1 NC_008611.1 membrane protein; hypothetical protein 2843236 4550075 MUL_2547 Mycobacterium ulcerans Agy99 hypothetical protein YP_906361.1 2842901 D 362242 CDS YP_906362.1 118618030 4550077 complement(2845567..2845914) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2845914 4550077 MUL_2549 Mycobacterium ulcerans Agy99 hypothetical protein YP_906362.1 2845567 R 362242 CDS YP_906363.1 118618031 4550078 complement(2845911..2847431) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2847431 4550078 MUL_2550 Mycobacterium ulcerans Agy99 hypothetical protein YP_906363.1 2845911 R 362242 CDS YP_906364.1 118618032 4550079 complement(2847510..2848106) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2848106 4550079 MUL_2551 Mycobacterium ulcerans Agy99 hypothetical protein YP_906364.1 2847510 R 362242 CDS YP_906365.1 118618033 4550080 complement(2848329..2848718) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2848718 4550080 MUL_2552 Mycobacterium ulcerans Agy99 hypothetical protein YP_906365.1 2848329 R 362242 CDS YP_906366.1 118618034 4550042 complement(2849026..2849340) 1 NC_008611.1 hypothetical protein 2849340 4550042 MUL_2553 Mycobacterium ulcerans Agy99 hypothetical protein YP_906366.1 2849026 R 362242 CDS YP_906367.1 118618035 4550043 complement(2849416..2850714) 1 NC_008611.1 membrane protein; hypothetical protein 2850714 4550043 MUL_2554 Mycobacterium ulcerans Agy99 hypothetical protein YP_906367.1 2849416 R 362242 CDS YP_906368.1 118618036 4550044 complement(2851502..2853409) 1 NC_008611.1 membrane protein; may be involved in regulation; hypothetical protein 2853409 4550044 MUL_2555 Mycobacterium ulcerans Agy99 hypothetical protein YP_906368.1 2851502 R 362242 CDS YP_906369.1 118618037 4550045 complement(2853419..2853742) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2853742 4550045 MUL_2556 Mycobacterium ulcerans Agy99 hypothetical protein YP_906369.1 2853419 R 362242 CDS YP_906370.1 118618038 4550046 complement(2853847..2855064) 1 NC_008611.1 hypothetical protein 2855064 4550046 MUL_2557 Mycobacterium ulcerans Agy99 hypothetical protein YP_906370.1 2853847 R 362242 CDS YP_906371.1 118618039 4550047 complement(2855189..2856073) 1 NC_008611.1 cytoplasmic protein; thought to be involved in fatty acid degradation. FadB and FadA are the alpha and BetA subunits of the multifunctional enzyme complex of the fatty acid degradation cycle [catalytic activity: (S)-3- hydroxybutanoyl-CoA + NADP+ = 3-acetoacetyl-CoA + NADPH]; 3-hydroxybutyryl-CoA dehydrogenase FadB3 2856073 fadB3 4550047 fadB3 Mycobacterium ulcerans Agy99 3-hydroxybutyryl-CoA dehydrogenase FadB3 YP_906371.1 2855189 R 362242 CDS YP_906372.1 118618040 4550048 complement(2856171..2856944) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2856944 4550048 MUL_2559 Mycobacterium ulcerans Agy99 hypothetical protein YP_906372.1 2856171 R 362242 CDS YP_906373.1 118618041 4550049 2856999..2858294 1 NC_008611.1 catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis; 3-phosphoshikimate 1-carboxyvinyltransferase 2858294 aroA 4550049 aroA Mycobacterium ulcerans Agy99 3-phosphoshikimate 1-carboxyvinyltransferase YP_906373.1 2856999 D 362242 CDS YP_906374.1 118618042 4550050 2858291..2859283 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2859283 4550050 MUL_2561 Mycobacterium ulcerans Agy99 hypothetical protein YP_906374.1 2858291 D 362242 CDS YP_906375.1 118618043 4550051 complement(2859270..2859737) 1 NC_008611.1 cytoplasmic protein; function unknown. could be involved in regulatory mechanism.; transcriptional regulatory protein 2859737 4550051 MUL_2562 Mycobacterium ulcerans Agy99 transcriptional regulatory protein YP_906375.1 2859270 R 362242 CDS YP_906376.1 118618044 4550052 2859832..2861013 1 NC_008611.1 cytoplasmic protein; function unknown, but involved in lipid metabolism [catalytic activity: 2 acetyl-CoA = CoA + acetoacetyl- CoA]; acetyl-CoA acetyltransferase FadA6_4 2861013 fadA6_4 4550052 fadA6_4 Mycobacterium ulcerans Agy99 acetyl-CoA acetyltransferase FadA6_4 YP_906376.1 2859832 D 362242 CDS YP_906377.1 118618045 4550053 complement(2861051..2862337) 1 NC_008611.1 cytoplasmic protein; thought to be involved in lipid metabolism [catalytic activity: linoleoyl-CoA + ah(2) + O(2) = gamma- linolenoyl-CoA + a + 2 H(2)O]; linoleoyl-CoA desaturase, DesA3_1 2862337 desA3_1 4550053 desA3_1 Mycobacterium ulcerans Agy99 linoleoyl-CoA desaturase, DesA3_1 YP_906377.1 2861051 R 362242 CDS YP_906378.1 118618046 4550054 complement(2862565..2863851) 1 NC_008611.1 cytoplasmic protein; thought to be involved in lipid metabolism [catalytic activity: linoleoyl-CoA + ah(2) + O(2) = gamma- linolenoyl-CoA + a + 2 H(2)O]; linoleoyl-CoA desaturase, DesA3 2863851 desA3 4550054 desA3 Mycobacterium ulcerans Agy99 linoleoyl-CoA desaturase, DesA3 YP_906378.1 2862565 R 362242 CDS YP_906379.1 118618047 4550055 complement(2863940..2865094) 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; function unknown, probably involved in cellular metabolism.; oxidoreductase 2865094 4550055 MUL_2566 Mycobacterium ulcerans Agy99 oxidoreductase YP_906379.1 2863940 R 362242 CDS YP_906380.1 118618048 4550056 complement(2865235..2865735) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2865735 4550056 MUL_2567 Mycobacterium ulcerans Agy99 hypothetical protein YP_906380.1 2865235 R 362242 CDS YP_906381.1 118618049 4550057 complement(2865801..2866673) 1 NC_008611.1 cytoplasmic protein; possibly involved in transcriptional mechanism (probably sigma factor promoting attachment of the RNA polymerase to specific initiation sites); transcriptional regulatory protein PvdS 2866673 pvdS 4550057 pvdS Mycobacterium ulcerans Agy99 transcriptional regulatory protein PvdS YP_906381.1 2865801 R 362242 CDS YP_906382.1 118618050 4550060 complement(2868896..2870041) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; probably involved in transport of undeterminated substrate (possibly cations Na/H) across the membrane. thought to be responsible for the translocation of the substrate across the membrane.; membrane transporter 2870041 4550060 MUL_2572 Mycobacterium ulcerans Agy99 membrane transporter YP_906382.1 2868896 R 362242 CDS YP_906383.1 118618051 4550026 complement(2870046..2870528) 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; function unknown but has a putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [inorganic ion transport and metabolism]; hypothetical protein 2870528 4550026 MUL_2573 Mycobacterium ulcerans Agy99 hypothetical protein YP_906383.1 2870046 R 362242 CDS YP_906384.1 118618052 4550027 complement(2870657..2871403) 1 NC_008611.1 membrane protein; hypothetical protein 2871403 4550027 MUL_2574 Mycobacterium ulcerans Agy99 hypothetical protein YP_906384.1 2870657 R 362242 CDS YP_906385.1 118618053 4550029 complement(2874774..2877626) 1 NC_008611.1 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins; preprotein translocase subunit SecA 2877626 secA1 4550029 secA1 Mycobacterium ulcerans Agy99 preprotein translocase subunit SecA YP_906385.1 2874774 R 362242 CDS YP_906386.1 118618054 4550030 complement(2877723..2878412) 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; function unknown but has domain identity with sigma 54 modulation protein; hypothetical protein 2878412 4550030 MUL_2577 Mycobacterium ulcerans Agy99 hypothetical protein YP_906386.1 2877723 R 362242 CDS YP_906387.1 118618055 4550031 complement(2878759..2879394) 1 NC_008611.1 cytoplasmic protein; function unknown, but contains amidophosphoribosyltransferase domain; hypothetical protein 2879394 4550031 MUL_2578 Mycobacterium ulcerans Agy99 hypothetical protein YP_906387.1 2878759 R 362242 CDS YP_906388.1 118618056 4550032 complement(2879437..2880267) 1 NC_008611.1 membrane protein; hypothetical protein 2880267 4550032 MUL_2579 Mycobacterium ulcerans Agy99 hypothetical protein YP_906388.1 2879437 R 362242 CDS YP_906389.1 118618057 4550033 complement(2880328..2882088) 1 NC_008611.1 membrane protein; lipoprotein LpqB 2882088 lpqB 4550033 lpqB Mycobacterium ulcerans Agy99 lipoprotein LpqB YP_906389.1 2880328 R 362242 CDS YP_906390.1 118618058 4550034 complement(2882106..2883785) 1 NC_008611.1 membrane protein; sensor part of a two component regulatory system.; two component sensory transduction histidine kinase MtrB 2883785 mtrB 4550034 mtrB Mycobacterium ulcerans Agy99 two component sensory transduction histidine kinase MtrB YP_906390.1 2882106 R 362242 CDS YP_906391.1 118618059 4550035 complement(2883835..2884521) 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS. Also detected in the membrane fraction by proteomics.; cytoplasmic protein; transcriptional activator part of a two component regulatory system.; two component sensory transduction transcriptional regulatory protein MtrA 2884521 mtrA 4550035 mtrA Mycobacterium ulcerans Agy99 two component sensory transduction transcriptional regulatory protein MtrA YP_906391.1 2883835 R 362242 CDS YP_906392.1 118618060 4550036 complement(2884576..2885244) 1 NC_008611.1 catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP); thymidylate kinase 2885244 tmk 4550036 tmk Mycobacterium ulcerans Agy99 thymidylate kinase YP_906392.1 2884576 R 362242 CDS YP_906393.1 118618061 4550038 2886621..2887667 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 2887667 4550038 MUL_2585 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_906393.1 2886621 D 362242 CDS YP_906394.1 118618062 4550039 2889049..2890095 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 2890095 4550039 MUL_2587 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_906394.1 2889049 D 362242 CDS YP_906395.1 118618063 4549868 complement(2892768..2894246) 1 NC_008611.1 catalyzes the formation of L-homocysteine from S-adenosyl-L-homocysteine; S-adenosyl-L-homocysteine hydrolase 2894246 sahH 4549868 sahH Mycobacterium ulcerans Agy99 S-adenosyl-L-homocysteine hydrolase YP_906395.1 2892768 R 362242 CDS YP_906396.1 118618064 4549869 complement(2894351..2895058) 1 NC_008611.1 cytoplasmic protein; probably involved in a transcriptional mechanism; TetR family transcriptional regulator 2895058 4549869 MUL_2593 Mycobacterium ulcerans Agy99 TetR family transcriptional regulator YP_906396.1 2894351 R 362242 CDS YP_906397.1 118618065 4549870 complement(2894998..2895180) 1 NC_008611.1 cytoplasmic protein; involved in the hydrocarbon hydroxylating system to convert conversion of dodecane to lauric acid, which transfers electrons from NADH to rubredoxin reductase and then through rubredoxin to alkane 1 monooxygenase.; rubredoxin RubB 2895180 rubB 4549870 rubB Mycobacterium ulcerans Agy99 rubredoxin RubB YP_906397.1 2894998 R 362242 CDS YP_906398.1 118618066 4549871 complement(2895181..2895351) 1 NC_008611.1 cytoplasmic protein; involved in the hydrocarbon hydroxylating system, which transfers electrons from NADH to rubredoxin reductase and then through rubredoxin to alkane 1 monooxygenase.; rubredoxin RubA 2895351 rubA 4549871 rubA Mycobacterium ulcerans Agy99 rubredoxin RubA YP_906398.1 2895181 R 362242 CDS YP_906399.1 118618067 4549873 complement(2896591..2898075) 1 NC_008611.1 membrane protein; thought to be involved in cationic amino acid transport across the membrane. responsible for the translocation of the substrate across the membrane.; cationic amino acid transport integral membrane protein 2898075 4549873 MUL_2597 Mycobacterium ulcerans Agy99 cationic amino acid transport integral membrane protein YP_906399.1 2896591 R 362242 CDS YP_906400.1 118618068 4549874 2898132..2899526 1 NC_008611.1 hypothetical protein 2899526 4549874 MUL_2598 Mycobacterium ulcerans Agy99 hypothetical protein YP_906400.1 2898132 D 362242 CDS YP_906401.1 118618069 4549875 2899569..2900975 1 NC_008611.1 cytoplasmic protein; function unknown but contains dehydrogenase domain; hypothetical protein 2900975 4549875 MUL_2599 Mycobacterium ulcerans Agy99 hypothetical protein YP_906401.1 2899569 D 362242 CDS YP_906402.1 118618070 4549876 complement(2900953..2902179) 1 NC_008611.1 cytoplasmic protein; this enzyme converts D-mannose 6-phosphate to D- fructose 6-phosphate [catalytic activity: D-mannose 6- phosphate = D-fructose 6-phosphate]; mannose-6-phosphate isomerase ManA 2902179 manA 4549876 manA Mycobacterium ulcerans Agy99 mannose-6-phosphate isomerase ManA YP_906402.1 2900953 R 362242 CDS YP_906403.1 118618071 4549877 complement(2902187..2903296) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2903296 4549877 MUL_2601 Mycobacterium ulcerans Agy99 hypothetical protein YP_906403.1 2902187 R 362242 CDS YP_906404.1 118618072 4549878 complement(2903293..2904693) 1 NC_008611.1 converts mannose-6-phosphate to mannose-1-phosphate; the resulting product is then converted to GDP-mannose by ManC which is then used in the synthesis of mannose-containing glycoconjugates that are important for mediating entry into host cells; phosphomannomutase/phosphoglucomutase 2904693 manB 4549878 manB Mycobacterium ulcerans Agy99 phosphomannomutase/phosphoglucomutase YP_906404.1 2903293 R 362242 CDS YP_906405.1 118618073 4549879 complement(2904840..2905337) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2905337 4549879 MUL_2603 Mycobacterium ulcerans Agy99 hypothetical protein YP_906405.1 2904840 R 362242 CDS YP_906406.1 118618074 4549880 2905352..2905882 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2905882 4549880 MUL_2604 Mycobacterium ulcerans Agy99 hypothetical protein YP_906406.1 2905352 D 362242 CDS YP_906407.1 118618075 4549881 complement(2905948..2906331) 1 NC_008611.1 cytoplasmic protein; involved in transcriptional mechanism.; transcriptional regulatory protein Whib-like WhiB2 2906331 whiB2 4549881 whiB2 Mycobacterium ulcerans Agy99 transcriptional regulatory protein Whib-like WhiB2 YP_906407.1 2905948 R 362242 CDS YP_906408.1 118618076 4549882 2906724..2907713 1 NC_008611.1 catalyzes the formation of the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) and GMP from actyl (2) diphospho-(5')guanosine (LPPG) to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO); LPPG:FO 2-phospho-L-lactate transferase 2907713 fbiA 4549882 fbiA Mycobacterium ulcerans Agy99 LPPG:FO 2-phospho-L-lactate transferase YP_906408.1 2906724 D 362242 CDS YP_906409.1 118618077 4549883 2907710..2909074 1 NC_008611.1 catalyzes the addition of gamma linked glutamate to 7,8-didemethyl-8-hydroxy-5-deazariboflavin coenzyme F420-0); F420-0--gamma-glutamyl ligase 2909074 fbiB 4549883 fbiB Mycobacterium ulcerans Agy99 F420-0--gamma-glutamyl ligase YP_906409.1 2907710 D 362242 CDS YP_906410.1 118618078 4549884 2909103..2910689 1 NC_008611.1 cytoplasmic protein; causes DNA methylation.; DNA methylase 2910689 4549884 MUL_2608 Mycobacterium ulcerans Agy99 DNA methylase YP_906410.1 2909103 D 362242 CDS YP_906411.1 118618079 4549885 2910728..2911234 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2911234 4549885 MUL_2609 Mycobacterium ulcerans Agy99 hypothetical protein YP_906411.1 2910728 D 362242 CDS YP_906412.1 118618080 4549886 complement(2911263..2912339) 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; involved in GDP-mannose biosynthesis and biosynthesis of nucleotide-activated glycero-manno-heptose (D-alpha-D pathway): generates GDP-mannose and phosphate from GTP and alpha-D-mannose 1-phosphate. ManB product is needed for all mannosyl glycolipids and polysaccharides which, like rhamnosyl residues, are an important part of the mycobacterium envelope [catalytic activity: alpha-D- mannose 1-phosphate + GTP = GDP-mannose + phosphate]; d-alpha-D-mannose-1-phosphate guanylyltransferase ManB 2912339 manB 4549886 manB Mycobacterium ulcerans Agy99 d-alpha-D-mannose-1-phosphate guanylyltransferase ManB YP_906412.1 2911263 R 362242 CDS YP_906413.1 118618081 4549849 complement(2912341..2913225) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; involved in cell wall arabinogalactan linker formation: uses dTDP-L-rhamnose as substrate to insert the rhamnosyl residue into the cell wall. seems to be essential for mycobacterial viability.; dTDP-rha:A-D-GlcNAc-diphosphoryl polyprenol A-3- L-rhamnosyl transferase, WbbL1 2913225 wbbL1 4549849 wbbL1 Mycobacterium ulcerans Agy99 dTDP-rha:A-D-GlcNAc-diphosphoryl polyprenol A-3- L-rhamnosyl transferase, WbbL1 YP_906413.1 2912341 R 362242 CDS YP_906414.1 118618082 4549850 complement(2913218..2914144) 1 NC_008611.1 cytoplasmic protein; involved in dTDP-L-rhamnose biosynthesis: converts dTDP-6-deoxy-L-lyxo-4-hexulose to dTDP-L-rhamnose with the concomitant oxidation of NADPH to NADP+ [catalytic activity: dTDP-6-deoxy-L-lyxo-4-hexulose + NADPH = dTDP-L- rhamnose + NADP+]; dTDP-6-deoxy-L-lyxo-4-hexulose reductase RmlD 2914144 rmlD 4549850 rmlD Mycobacterium ulcerans Agy99 dTDP-6-deoxy-L-lyxo-4-hexulose reductase RmlD YP_906414.1 2913218 R 362242 CDS YP_906415.1 118618083 4549851 2914209..2915669 1 NC_008611.1 membrane protein; hypothetical protein 2915669 4549851 MUL_2613 Mycobacterium ulcerans Agy99 hypothetical protein YP_906415.1 2914209 D 362242 CDS YP_906416.1 118618084 4549852 2915699..2916379 1 NC_008611.1 hypothetical protein 2916379 4549852 MUL_2614 Mycobacterium ulcerans Agy99 hypothetical protein YP_906416.1 2915699 D 362242 CDS YP_906417.1 118618085 4549853 2916495..2916773 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; function unknown.; hypothetical protein 2916773 4549853 MUL_2615 Mycobacterium ulcerans Agy99 hypothetical protein YP_906417.1 2916495 D 362242 CDS YP_906418.1 118618086 4549854 2916783..2918981 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; metal cation-transporting ATPase; possibly catalyzes the transport of undetermined metal cation with the hydrolyse of ATP [catalytic activity: ATP + H(2)O + undeterminated metal cation(in) = ADP + phosphate + undeterminated metal cation(out)]; metal cation-transporting p-type ATPase C CtpC 2918981 ctpC 4549854 ctpC Mycobacterium ulcerans Agy99 metal cation-transporting p-type ATPase C CtpC YP_906418.1 2916783 D 362242 CDS YP_906419.1 118618087 4549855 complement(2919025..2919726) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2919726 4549855 MUL_2617 Mycobacterium ulcerans Agy99 hypothetical protein YP_906419.1 2919025 R 362242 CDS YP_906420.1 118618088 4549857 2921595..2922341 1 NC_008611.1 cytoplasmic protein; function unknown, potential regulatory function; hypothetical protein 2922341 4549857 MUL_2620 Mycobacterium ulcerans Agy99 hypothetical protein YP_906420.1 2921595 D 362242 CDS YP_906421.1 118618089 4549858 2922436..2923623 1 NC_008611.1 cytoplasmic protein; acyl-CoA transferase 2923623 4549858 MUL_2621 Mycobacterium ulcerans Agy99 acyl-CoA transferase YP_906421.1 2922436 D 362242 CDS YP_906422.1 118618090 4549860 complement(2926160..2926600) 1 NC_008611.1 membrane protein; sensor part of the two component regulatory system.; two component transcriptional regulator 2926600 4549860 MUL_2623 Mycobacterium ulcerans Agy99 two component transcriptional regulator YP_906422.1 2926160 R 362242 CDS YP_906423.1 118618091 4549861 complement(2926597..2928219) 1 NC_008611.1 membrane protein; two component system membrane associated sensor kinase 2928219 4549861 MUL_2624 Mycobacterium ulcerans Agy99 two component system membrane associated sensor kinase YP_906423.1 2926597 R 362242 CDS YP_906424.1 118618092 4549862 complement(2928216..2929454) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2929454 4549862 MUL_2625 Mycobacterium ulcerans Agy99 hypothetical protein YP_906424.1 2928216 R 362242 CDS YP_906425.1 118618093 4549863 complement(2929648..2930817) 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; function unknown, but involved in lipid metabolism [catalytic activity: acyl-CoA + ETF = 2,3-dehydroacyl-CoA + reduced ETF]; acyl-CoA dehydrogenase FadE25 2930817 fadE25 4549863 fadE25 Mycobacterium ulcerans Agy99 acyl-CoA dehydrogenase FadE25 YP_906425.1 2929648 R 362242 CDS YP_906426.1 118618094 4549864 complement(2930842..2931357) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); cytoplasmic protein; nvolved in purine biosynthesis (sixth step) this subunit can alone transform air to cair, but in association with PurK, which possesses an ATPase activity, an enzyme complex is produced which is capable of converting air to cair efficiently under physiol; phosphoribosylaminoimidazole carboxylase catalytic subunit PurE (air carboxylase) (AirC) 2931357 purE 4549864 purE Mycobacterium ulcerans Agy99 phosphoribosylaminoimidazole carboxylase catalytic subunit PurE (air carboxylase) (AirC) YP_906426.1 2930842 R 362242 CDS YP_906427.1 118618095 4549865 complement(2931350..2932624) 1 NC_008611.1 With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway; phosphoribosylaminoimidazole carboxylase ATPase subunit 2932624 purK 4549865 purK Mycobacterium ulcerans Agy99 phosphoribosylaminoimidazole carboxylase ATPase subunit YP_906427.1 2931350 R 362242 CDS YP_906428.1 118618096 4549866 2932664..2933347 1 NC_008611.1 membrane protein; hypothetical protein 2933347 4549866 MUL_2629 Mycobacterium ulcerans Agy99 hypothetical protein YP_906428.1 2932664 D 362242 CDS YP_906429.1 118618097 4549867 complement(2933302..2933820) 1 NC_008611.1 membrane protein; hypothetical protein 2933820 4549867 MUL_2630 Mycobacterium ulcerans Agy99 hypothetical protein YP_906429.1 2933302 R 362242 CDS YP_906430.1 118618098 4549829 complement(2933883..2934713) 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; BirA acts both as a biotin-operon repressor and as the enzyme that synthesizes the corepressor, acetyl- CoA:carbon-dioxide ligase. this protein also activates biotin to form biotinyl-5'-adenylate and transfers the biotin moiety to biotin-accepting proteins [catalytic activity: ATP + biotin + apo-[acetyl-CoA:carbon-dioxide ligase (ADP forming)] = AMP + pyrophosphate + [acetyl- CoA:carbon-dioxide ligase (ADP forming)]]; bifunctional protein BirA 2934713 birA 4549829 birA Mycobacterium ulcerans Agy99 bifunctional protein BirA YP_906430.1 2933883 R 362242 CDS YP_906431.1 118618099 4549830 2934864..2936504 1 NC_008611.1 Detected in the cytoplamic fraction by LC-MS/MS. Also detected in the extracellular matrix and membrane fraction by proteomics.; cytoplasmic protein; key enzyme in the catabolic pathway of odd-chain fatty acids, isoleucine, threonine, methionine, and valine [catalytic activity: ATP + propionyl-CoA + CO(2) + H(2)O = ADP + orthophosphate + methylmalonyl-CoA]; propionyl-CoA carboxylase beta chain 5 AccD5 2936504 accD5 4549830 accD5 Mycobacterium ulcerans Agy99 propionyl-CoA carboxylase beta chain 5 AccD5 YP_906431.1 2934864 D 362242 CDS YP_906432.1 118618100 4549831 2936501..2936821 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2936821 4549831 MUL_2633 Mycobacterium ulcerans Agy99 hypothetical protein YP_906432.1 2936501 D 362242 CDS YP_906433.1 118618101 4549832 2936818..2937468 1 NC_008611.1 Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell; Maf-like protein 2937468 4549832 MUL_2634 Mycobacterium ulcerans Agy99 Maf-like protein YP_906433.1 2936818 D 362242 CDS YP_906434.1 118618102 4549833 2937508..2938413 1 NC_008611.1 cytoplasmic protein; possibly a sulfotransferase involved in the formation of thiosulfate [catalytic activity: thiosulfate + cyanide = sulfite + thiocyanate]; thiosulfate sulfurtransferase SseA 2938413 sseA 4549833 sseA Mycobacterium ulcerans Agy99 thiosulfate sulfurtransferase SseA YP_906434.1 2937508 D 362242 CDS YP_906435.1 118618103 4549834 2938410..2938829 1 NC_008611.1 cytoplasmic protein; probably involved in Fe-S center assembly; Fe-S metabolism associated protein, SufE 2938829 sufE 4549834 sufE Mycobacterium ulcerans Agy99 Fe-S metabolism associated protein, SufE YP_906435.1 2938410 D 362242 CDS YP_906436.1 118618104 4549835 2938940..2940733 1 NC_008611.1 Detected in the cytoplasmic fraction by proteomics (2D-LC-MS/MS) Also detected in the extracellular matrix and membrane fraction by proteomics.; cytoplasmic protein; involved in long-chain fatty acid synthesis (at the first step) carries two functions: biotin carboxyl carrier protein and biotin carboxyltransferase [catalytic activity: ATP + biotin-carboxyl-carrier protein + CO(2) = ADP + orthophosphate + carboxybiotin-carboxyl-carrier protein]; bifunctional protein acetyl-/propionyl-coenzyme a carboxylase (alpha chain) AccA3 2940733 accA3 4549835 accA3 Mycobacterium ulcerans Agy99 bifunctional protein acetyl-/propionyl-coenzyme a carboxylase (alpha chain) AccA3 YP_906436.1 2938940 D 362242 CDS YP_906437.1 118618105 4549836 complement(2940775..2950209) 1 NC_008611.1 cytoplasmic protein; function unknown but contains 3 modules for the potential synthesis of a tripeptide; peptide synthetase Nrp (peptide synthase) 2950209 4549836 MUL_2638 Mycobacterium ulcerans Agy99 peptide synthetase Nrp (peptide synthase) YP_906437.1 2940775 R 362242 CDS YP_906438.1 118618106 4549837 2950837..2951406 1 NC_008611.1 cytoplasmic protein; involved in transcriptional mechanism.; transcriptional regulatory protein 2951406 4549837 MUL_2639 Mycobacterium ulcerans Agy99 transcriptional regulatory protein YP_906438.1 2950837 D 362242 CDS YP_906439.1 118618107 4549838 complement(2951468..2952256) 1 NC_008611.1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor is a general stress response regulator; expressed in stationary phase and under nitrogen depletion and cold shock; RNA polymerase sigma factor SigF 2952256 sigF 4549838 sigF Mycobacterium ulcerans Agy99 RNA polymerase sigma factor SigF YP_906439.1 2951468 R 362242 CDS YP_906440.1 118618108 4549839 complement(2952253..2952690) 1 NC_008611.1 cytoplasmic protein; binds to sigma and blocks its ability to form an RNA polymerase holoenzyme. regulates negatively SigF and negatively regulated by RsfA and RsfB.; anti-sigma factor RsbW 2952690 rsbW 4549839 rsbW Mycobacterium ulcerans Agy99 anti-sigma factor RsbW YP_906440.1 2952253 R 362242 CDS YP_906441.1 118618109 4549840 complement(2952768..2952980) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2952980 4549840 MUL_5106 Mycobacterium ulcerans Agy99 hypothetical protein YP_906441.1 2952768 R 362242 CDS YP_906442.1 118618110 4549841 complement(2953173..2953484) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2953484 usfY 4549841 usfY Mycobacterium ulcerans Agy99 hypothetical protein YP_906442.1 2953173 R 362242 CDS YP_906443.1 118618111 4549842 complement(2953597..2953983) 1 NC_008611.1 membrane protein; hypothetical protein 2953983 4549842 MUL_2643 Mycobacterium ulcerans Agy99 hypothetical protein YP_906443.1 2953597 R 362242 CDS YP_906444.1 118618112 4549843 complement(2954063..2955403) 1 NC_008611.1 catalyzes the formation of 2-aminoadipate 6-semiladehyde and glutamate from lysine and 2-oxoglutarate; L-lysine aminotransferase 2955403 lat 4549843 lat Mycobacterium ulcerans Agy99 L-lysine aminotransferase YP_906444.1 2954063 R 362242 CDS YP_906445.1 118618113 4549844 complement(2955457..2955909) 1 NC_008611.1 cytoplasmic protein; involved in transcriptional mechanism.; AsnC family transcriptional regulator 2955909 4549844 MUL_2645 Mycobacterium ulcerans Agy99 AsnC family transcriptional regulator YP_906445.1 2955457 R 362242 CDS YP_906446.1 118618114 4549845 2955943..2957214 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2957214 4549845 MUL_2646 Mycobacterium ulcerans Agy99 hypothetical protein YP_906446.1 2955943 D 362242 CDS YP_906447.1 118618115 4549846 2957292..2958806 1 NC_008611.1 cytoplasmic protein; involved in L-alpha-aminoadipic acid (L-AAA) biosynthesis (in the second step; the first step is promoted by Lat enzyme.; piperideine-6-carboxilic acid dehydrogenase Pcd 2958806 pcd 4549846 pcd Mycobacterium ulcerans Agy99 piperideine-6-carboxilic acid dehydrogenase Pcd YP_906447.1 2957292 D 362242 CDS YP_906448.1 118618116 4549847 2958855..2959529 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; involved in transcriptional mechanism.; TetR family transcriptional regulator 2959529 4549847 MUL_2648 Mycobacterium ulcerans Agy99 TetR family transcriptional regulator YP_906448.1 2958855 D 362242 CDS YP_906449.1 118618117 4549775 2964187..2964951 1 NC_008611.1 cytoplasmic protein; involved in damage reversal. DNA N-glycosylase with an ap lyase activity. required for the repair of oxidative DNA damage (oxidized pyrimidines); endonuclease VIII Nei 2964951 nei 4549775 nei Mycobacterium ulcerans Agy99 endonuclease VIII Nei YP_906449.1 2964187 D 362242 CDS YP_906450.1 118618118 4549776 complement(2964966..2965883) 1 NC_008611.1 membrane protein; function unknown, lipolytic enzyme involved in cellular metabolism.; esterase lipoprotein LpqC 2965883 lpqC 4549776 lpqC Mycobacterium ulcerans Agy99 esterase lipoprotein LpqC YP_906450.1 2964966 R 362242 CDS YP_906451.1 118618119 4549778 complement(2966407..2966724) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; C-term transposase for IS2404 2966724 4549778 MUL_2653 Mycobacterium ulcerans Agy99 C-term transposase for IS2404 YP_906451.1 2966407 R 362242 CDS YP_906452.1 118618120 4549779 complement(2966749..2967453) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; N-term transposase for IS2404 2967453 4549779 MUL_2654 Mycobacterium ulcerans Agy99 N-term transposase for IS2404 YP_906452.1 2966749 R 362242 CDS YP_906453.1 118618121 4549780 complement(2968550..2969662) 1 NC_008611.1 membrane protein; involved in active transport of inorganic phosphate across the membrane (import) this is one of the proteins required for binding-protein-mediated phosphate transport.; periplasmic phosphate-binding lipoprotein PhoS2_1 2969662 phoS2_1 4549780 phoS2_1 Mycobacterium ulcerans Agy99 periplasmic phosphate-binding lipoprotein PhoS2_1 YP_906453.1 2968550 R 362242 CDS YP_906454.1 118618122 4549781 2969740..2970243 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2970243 4549781 MUL_2657 Mycobacterium ulcerans Agy99 hypothetical protein YP_906454.1 2969740 D 362242 CDS YP_906455.1 118618123 4549782 complement(2970265..2973156) 1 NC_008611.1 membrane protein; generates sulfate and phenol from phenol sulfate [catalytic activity: a phenol sulfate + H(2)O = a phenol + sulfate]; arylsulfatase AtsB (aryl-sulfate sulphohydrolase) 2973156 atsB 4549782 atsB Mycobacterium ulcerans Agy99 arylsulfatase AtsB (aryl-sulfate sulphohydrolase) YP_906455.1 2970265 R 362242 CDS YP_906456.1 118618124 4549783 complement(2973178..2974044) 1 NC_008611.1 cytoplasmic protein; catalyses the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); pseudouridine synthase 2974044 4549783 MUL_2659 Mycobacterium ulcerans Agy99 pseudouridine synthase YP_906456.1 2973178 R 362242 CDS YP_906457.1 118618125 4549785 complement(2975289..2975954) 1 NC_008611.1 cytoplasmic protein; involved in transcriptional regulation of active transport of inorganic phosphate across the membrane.; phosphate-transport system transcriptional regulatory protein PhoY1 2975954 phoY1 4549785 phoY1 Mycobacterium ulcerans Agy99 phosphate-transport system transcriptional regulatory protein PhoY1 YP_906457.1 2975289 R 362242 CDS YP_906458.1 118618126 4549789 complement(2981516..2983060) 1 NC_008611.1 membrane protein; function unknown but may be involved in glutamate biosynthesis [catalytic activity: 2 L-glutamate + NADP(+) = L-glutamine + 2-oxoglutarate + NADPH]; glutamate synthase, GltB_1 2983060 gltB_1 4549789 gltB_1 Mycobacterium ulcerans Agy99 glutamate synthase, GltB_1 YP_906458.1 2981516 R 362242 CDS YP_906459.1 118618127 4549790 complement(2983468..2985225) 1 NC_008611.1 Detected in the membrane fraction by proteomics (2D- LC-MS/MS); cytoplasmic protein; involved in aerobic respiration and oxydation of glycerol. reduces an acceptor and generates glycerone phosphate from SN-glycerol 3-phosphate. possibly play a role in metabolism of riboflavin, fad,FMN [catalytic activity: SN-glycerol 3-phosphate + acceptor = glycerone phosphate + reduced acceptor]; glycerol-3-phosphate dehydrogenase GlpD2 2985225 glpD2 4549790 glpD2 Mycobacterium ulcerans Agy99 glycerol-3-phosphate dehydrogenase GlpD2 YP_906459.1 2983468 R 362242 CDS YP_906460.1 118618128 4549791 complement(2985310..2986722) 1 NC_008611.1 catalyzes the reduction of nonspecific electron acceptors such as 2,6-dimethyl-1,4-benzoquinone and 5-hydroxy-1,4-naphthaquinone; does not have lipoamide dehydrogenase activity; flavoprotein disulfide reductase 2986722 lpdA 4549791 lpdA Mycobacterium ulcerans Agy99 flavoprotein disulfide reductase YP_906460.1 2985310 R 362242 CDS YP_906461.1 118618129 4549792 2986864..2987343 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2987343 4549792 MUL_2669 Mycobacterium ulcerans Agy99 hypothetical protein YP_906461.1 2986864 D 362242 CDS YP_906462.1 118618130 4549758 complement(2987435..2988280) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 2988280 4549758 MUL_2670 Mycobacterium ulcerans Agy99 hypothetical protein YP_906462.1 2987435 R 362242 CDS YP_906463.1 118618131 4549759 complement(2988434..2989603) 1 NC_008611.1 membrane protein; function unknown, hydrolysis of L-amino acids.; N-acyl-L-amino acid amidohydrolase AmiA1 2989603 amiA1 4549759 amiA1 Mycobacterium ulcerans Agy99 N-acyl-L-amino acid amidohydrolase AmiA1 YP_906463.1 2988434 R 362242 CDS YP_906464.1 118618132 4549760 complement(2989600..2990781) 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; involved in cellular metabolism, active on carbon aliphatic amides and/or on many aromatic amides [catalytic activity : a monocarboxylic acid amide + H(2)O = a monocarboxylate + NH(3)]; amidohydrolase AmiB1 2990781 amiB1 4549760 amiB1 Mycobacterium ulcerans Agy99 amidohydrolase AmiB1 YP_906464.1 2989600 R 362242 CDS YP_906465.1 118618133 4549761 2990864..2991685 1 NC_008611.1 catalyzes the formation of a purine and ribose phosphate from a purine nucleoside; in E. coli this enzyme functions in xanthosine degradation; purine nucleoside phosphorylase 2991685 deoD 4549761 deoD Mycobacterium ulcerans Agy99 purine nucleoside phosphorylase YP_906465.1 2990864 D 362242 CDS YP_906466.1 118618134 4549762 2991675..2993255 1 NC_008611.1 cytoplasmic protein; converts D-mannose 1-phosphate to D-mannose 6- phosphate.; phosphomannomutase PmmB 2993255 pmmB 4549762 pmmB Mycobacterium ulcerans Agy99 phosphomannomutase PmmB YP_906466.1 2991675 D 362242 CDS YP_906467.1 118618135 4549763 complement(2993257..2993826) 1 NC_008611.1 Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate; uracil phosphoribosyltransferase 2993826 upp 4549763 upp Mycobacterium ulcerans Agy99 uracil phosphoribosyltransferase YP_906467.1 2993257 R 362242 CDS YP_906468.1 118618136 4549764 2994021..2994863 1 NC_008611.1 cytoplasmic protein; involved in cellular metabolism: acting on ester bonds [catalytic activity: an orthophosphoric monoester + H(2)O = an alcohol + orthophosphate]; acid phosphatase 2994863 4549764 MUL_2676 Mycobacterium ulcerans Agy99 acid phosphatase YP_906468.1 2994021 D 362242 CDS YP_906469.1 118618137 4549765 2994912..2996237 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; hypothetical protein 2996237 4549765 MUL_2677 Mycobacterium ulcerans Agy99 hypothetical protein YP_906469.1 2994912 D 362242 CDS YP_906470.1 118618138 4549766 complement(2996294..2997190) 1 NC_008611.1 cytoplasmic protein; function unknown but contains hydrolase domain; hypothetical protein 2997190 4549766 MUL_2678 Mycobacterium ulcerans Agy99 hypothetical protein YP_906470.1 2996294 R 362242 CDS YP_906471.1 118618139 4549767 2997293..2998672 1 NC_008611.1 cytoplasmic protein; function unknown. thought to be regulated by LexA; 13e12 repeat-containing protein 2998672 4549767 MUL_2679 Mycobacterium ulcerans Agy99 13e12 repeat-containing protein YP_906471.1 2997293 D 362242 CDS YP_906472.1 118618140 4549768 2998872..3000269 1 NC_008611.1 membrane protein; function unknown but contains permease domain and may be involved in nucleotide transport (cytosine/purines) and metabolism/coenzyme metabolism; hypothetical protein 3000269 4549768 MUL_2680 Mycobacterium ulcerans Agy99 hypothetical protein YP_906472.1 2998872 D 362242 CDS YP_906473.1 118618141 4549769 complement(3000377..3001288) 1 NC_008611.1 Detected in the cytoplamic fraction by LCMSMS; cytoplasmic protein; function unknown, contains xylanase/chitin deacetylase domain; chitinase 3001288 4549769 MUL_2681 Mycobacterium ulcerans Agy99 chitinase YP_906473.1 3000377 R 362242 CDS YP_906474.1 118618142 4549770 complement(3001285..3002244) 1 NC_008611.1 catalyzes the formation of S-ureidoglycolate and urea from allantoate; allantoicase 3002244 alc 4549770 alc Mycobacterium ulcerans Agy99 allantoicase YP_906474.1 3001285 R 362242 CDS YP_906475.1 118618143 4549771 complement(3002241..3003539) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3003539 4549771 MUL_2683 Mycobacterium ulcerans Agy99 hypothetical protein YP_906475.1 3002241 R 362242 CDS YP_906476.1 118618144 4549773 3005342..3006388 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 3006388 4549773 MUL_2685 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_906476.1 3005342 D 362242 CDS YP_906477.1 118618145 4549774 complement(3006538..3007185) 1 NC_008611.1 membrane protein; PPE family protein 3007185 4549774 MUL_2686 Mycobacterium ulcerans Agy99 PPE family protein YP_906477.1 3006538 R 362242 CDS YP_906478.1 118618146 4549689 3008107..3008811 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; N-term transposase for IS2404 3008811 4549689 MUL_2688 Mycobacterium ulcerans Agy99 N-term transposase for IS2404 YP_906478.1 3008107 D 362242 CDS YP_906479.1 118618147 4549690 3008836..3009153 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; C-term transposase for IS2404 3009153 4549690 MUL_2689 Mycobacterium ulcerans Agy99 C-term transposase for IS2404 YP_906479.1 3008836 D 362242 CDS YP_906480.1 118618148 4549691 complement(3010350..3010589) 1 NC_008611.1 cytoplasmic protein; transposition of an insertion sequence; transposase ISMmr01_aa2-like 3010589 4549691 MUL_2691 Mycobacterium ulcerans Agy99 transposase ISMmr01_aa2-like YP_906480.1 3010350 R 362242 CDS YP_906481.1 118618149 4549692 complement(3010597..3010878) 1 NC_008611.1 cytoplasmic protein; transposition of an insertion sequence; transposase ISMmr01_aa1-like 3010878 4549692 MUL_2692 Mycobacterium ulcerans Agy99 transposase ISMmr01_aa1-like YP_906481.1 3010597 R 362242 CDS YP_906482.1 118618150 4549693 complement(3011055..3012377) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3012377 4549693 MUL_2693 Mycobacterium ulcerans Agy99 hypothetical protein YP_906482.1 3011055 R 362242 CDS YP_906483.1 118618151 4549694 3012841..3014460 1 NC_008611.1 membrane protein; involved in phosphate transport.; phosphate-transport permease PitB 3014460 pitB 4549694 pitB Mycobacterium ulcerans Agy99 phosphate-transport permease PitB YP_906483.1 3012841 D 362242 CDS YP_906484.1 118618152 4549696 3016215..3016949 1 NC_008611.1 catalyzes the reduction of 3'-phosphoadenylyl sulfate into sulfite; phosphoadenosine phosphosulfate reductase 3016949 cysH_1 4549696 cysH_1 Mycobacterium ulcerans Agy99 phosphoadenosine phosphosulfate reductase YP_906484.1 3016215 D 362242 CDS YP_906485.1 118618153 4549697 3016946..3017665 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3017665 4549697 MUL_2697 Mycobacterium ulcerans Agy99 hypothetical protein YP_906485.1 3016946 D 362242 CDS YP_906486.1 118618154 4549698 complement(3017686..3018624) 1 NC_008611.1 cytoplasmic protein; LysR family transcriptional regulator 3018624 4549698 MUL_2698 Mycobacterium ulcerans Agy99 LysR family transcriptional regulator YP_906486.1 3017686 R 362242 CDS YP_906487.1 118618155 4549699 3018711..3019973 1 NC_008611.1 secreted protein; generates oxidized ferredoxin from ferredoxin [catalytic activity: reduced ferredoxin + NADP(+) = oxidized ferredoxin + NADPH]; NADPH:adrenodoxin oxidoreductase FprA 3019973 fprA 4549699 fprA Mycobacterium ulcerans Agy99 NADPH:adrenodoxin oxidoreductase FprA YP_906487.1 3018711 D 362242 CDS YP_906488.1 118618156 4549700 3020098..3020424 1 NC_008611.1 cytoplasmic protein; ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.; ferredoxin FdxC_1 3020424 fdxC_1 4549700 fdxC_1 Mycobacterium ulcerans Agy99 ferredoxin FdxC_1 YP_906488.1 3020098 D 362242 CDS YP_906489.1 118618157 4549701 complement(3020551..3021144) 1 NC_008611.1 Detected in the membrane fraction by proteomics (2D- LC-MS/MS); cytoplasmic protein; function unknown. possibly involved in transcriptional mechanism.; transcriptional regulatory protein 3021144 4549701 MUL_2701 Mycobacterium ulcerans Agy99 transcriptional regulatory protein YP_906489.1 3020551 R 362242 CDS YP_906490.1 118618158 4549702 complement(3021329..3021988) 1 NC_008611.1 membrane protein; PE-PGRS family protein 3021988 4549702 MUL_2702 Mycobacterium ulcerans Agy99 PE-PGRS family protein YP_906490.1 3021329 R 362242 CDS YP_906491.1 118618159 4549703 complement(3022424..3022798) 1 NC_008611.1 cytoplasmic protein; function unknown but contains zinc binding domain found at the N-terminus of the ClpX protein. ClpX is an ATPase which functions both as a substrate specificity component of the ClpXP protease and as a molecular chaperone.; hypothetical protein 3022798 4549703 MUL_2703 Mycobacterium ulcerans Agy99 hypothetical protein YP_906491.1 3022424 R 362242 CDS YP_906492.1 118618160 4549704 3022900..3024162 1 NC_008611.1 membrane protein; hydrolysis of lipids (bound ester); membrane-bound esterase LipM 3024162 lipM 4549704 lipM Mycobacterium ulcerans Agy99 membrane-bound esterase LipM YP_906492.1 3022900 D 362242 CDS YP_906493.1 118618161 4549705 3024174..3025160 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3025160 4549705 MUL_2705 Mycobacterium ulcerans Agy99 hypothetical protein YP_906493.1 3024174 D 362242 CDS YP_906494.1 118618162 4549669 3025349..3026689 1 NC_008611.1 hypothetical protein 3026689 4549669 MUL_2706 Mycobacterium ulcerans Agy99 hypothetical protein YP_906494.1 3025349 D 362242 CDS YP_906495.1 118618163 4549670 3026722..3027918 1 NC_008611.1 cytoplasmic protein; function unknown, probably involved in cellular metabolism.; oxidoreductase 3027918 4549670 MUL_2707 Mycobacterium ulcerans Agy99 oxidoreductase YP_906495.1 3026722 D 362242 CDS YP_906496.1 118618164 4549671 complement(3027924..3028619) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3028619 4549671 MUL_2708 Mycobacterium ulcerans Agy99 hypothetical protein YP_906496.1 3027924 R 362242 CDS YP_906497.1 118618165 4549672 complement(3028761..3029201) 1 NC_008611.1 membrane protein; hypothetical protein 3029201 4549672 MUL_2710 Mycobacterium ulcerans Agy99 hypothetical protein YP_906497.1 3028761 R 362242 CDS YP_906498.1 118618166 4549675 3031647..3032693 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 3032693 4549675 MUL_2713 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_906498.1 3031647 D 362242 CDS YP_906499.1 118618167 4549676 3033892..3034542 1 NC_008611.1 cytoplasmic protein; involved in transcriptional mechanism.; TetR family transcriptional regulator 3034542 4549676 MUL_2714 Mycobacterium ulcerans Agy99 TetR family transcriptional regulator YP_906499.1 3033892 D 362242 CDS YP_906500.1 118618168 4549678 3036126..3037010 1 NC_008611.1 cytoplasmic protein; function unknown but contains oxidoreductase domain; hypothetical protein 3037010 4549678 MUL_2716 Mycobacterium ulcerans Agy99 hypothetical protein YP_906500.1 3036126 D 362242 CDS YP_906501.1 118618169 4549679 3037007..3037741 1 NC_008611.1 hypothetical protein 3037741 4549679 MUL_2717 Mycobacterium ulcerans Agy99 hypothetical protein YP_906501.1 3037007 D 362242 CDS YP_906502.1 118618170 4549681 3037970..3039103 1 NC_008611.1 PPE61; membrane protein; PPE family protein 3039103 4549681 MUL_2718 Mycobacterium ulcerans Agy99 PPE family protein YP_906502.1 3037970 D 362242 CDS YP_906503.1 118618171 4549682 complement(3039179..3039973) 1 NC_008611.1 secreted protein; involved in phospholipid biosynthesis [catalytic activity: CDP-diacylglycerol + H(2)O = CMP + phosphatidate]; CDP-diacylglycerol pyrophosphatase 3039973 cdh 4549682 cdh Mycobacterium ulcerans Agy99 CDP-diacylglycerol pyrophosphatase YP_906503.1 3039179 R 362242 CDS YP_906504.1 118618172 4549683 complement(3040184..3040783) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; hypothetical protein 3040783 4549683 MUL_2720 Mycobacterium ulcerans Agy99 hypothetical protein YP_906504.1 3040184 R 362242 CDS YP_906505.1 118618173 4549684 complement(3040780..3041373) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3041373 4549684 MUL_2721 Mycobacterium ulcerans Agy99 hypothetical protein YP_906505.1 3040780 R 362242 CDS YP_906506.1 118618174 4549685 3041372..3042619 1 NC_008611.1 hypothetical protein 3042619 4549685 MUL_2722 Mycobacterium ulcerans Agy99 hypothetical protein YP_906506.1 3041372 D 362242 CDS YP_906507.1 118618175 4549686 3042672..3043667 1 NC_008611.1 cytoplasmic protein; hydrolase 3043667 4549686 MUL_2723 Mycobacterium ulcerans Agy99 hydrolase YP_906507.1 3042672 D 362242 CDS YP_906508.1 118618176 4549687 complement(3043739..3044038) 1 NC_008611.1 membrane protein; hypothetical protein 3044038 4549687 MUL_2724 Mycobacterium ulcerans Agy99 hypothetical protein YP_906508.1 3043739 R 362242 CDS YP_906509.1 118618177 4552879 3044485..3045327 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3045327 4552879 MUL_2725 Mycobacterium ulcerans Agy99 hypothetical protein YP_906509.1 3044485 D 362242 CDS YP_906510.1 118618178 4552880 3045590..3046669 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3046669 4552880 MUL_2726 Mycobacterium ulcerans Agy99 hypothetical protein YP_906510.1 3045590 D 362242 CDS YP_906511.1 118618179 4552881 3046737..3047936 1 NC_008611.1 cytoplasmic protein; aminotransferase 3047936 4552881 MUL_2727 Mycobacterium ulcerans Agy99 aminotransferase YP_906511.1 3046737 D 362242 CDS YP_906512.1 118618180 4552882 complement(3047940..3048485) 1 NC_008611.1 cytoplasmic protein; putative regulatory protein 3048485 4552882 MUL_2728 Mycobacterium ulcerans Agy99 putative regulatory protein YP_906512.1 3047940 R 362242 CDS YP_906513.1 118618181 4552883 3048509..3049468 1 NC_008611.1 membrane protein; hypothetical protein 3049468 4552883 MUL_2729 Mycobacterium ulcerans Agy99 hypothetical protein YP_906513.1 3048509 D 362242 CDS YP_906514.1 118618182 4552884 complement(3049487..3050215) 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; could help control the pool of 3'-phosphoadenoside 5'-phosphosulfate, or its use in sulfite synthesis (by similarity); monophosphatase CysQ_1 3050215 cysQ_1 4552884 cysQ_1 Mycobacterium ulcerans Agy99 monophosphatase CysQ_1 YP_906514.1 3049487 R 362242 CDS YP_906515.1 118618183 4552889 complement(3053998..3055044) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 3055044 4552889 MUL_2734 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_906515.1 3053998 R 362242 CDS YP_906516.1 118618184 4552890 3055895..3057229 1 NC_008611.1 cytoplasmic protein; required for the transposition of the insertion element IS2606; transposase for IS2606 3057229 4552890 MUL_2735 Mycobacterium ulcerans Agy99 transposase for IS2606 YP_906516.1 3055895 D 362242 CDS YP_906517.1 118618185 4552891 complement(3057353..3058399) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 3058399 4552891 MUL_2736 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_906517.1 3057353 R 362242 CDS YP_906518.1 118618186 4552892 3059209..3059388 1 NC_008611.1 potential pseuodgene; cytoplasmic protein; transposase 3059388 4552892 MUL_5108 Mycobacterium ulcerans Agy99 transposase YP_906518.1 3059209 D 362242 CDS YP_906519.1 118618187 4552893 complement(3060048..3061193) 1 NC_008611.1 PPE51_1; detected in the membranr fraction by proteomics.; membrane protein; PPE family protein 3061193 4552893 MUL_2737 Mycobacterium ulcerans Agy99 PPE family protein YP_906519.1 3060048 R 362242 CDS YP_906520.1 118618188 4552895 complement(3061983..3062960) 1 NC_008611.1 cytoplasmic protein; function unknown but contains metal-dependant hydrolase domain identity; hypothetical protein 3062960 4552895 MUL_2738 Mycobacterium ulcerans Agy99 hypothetical protein YP_906520.1 3061983 R 362242 CDS YP_906521.1 118618189 4552896 3062991..3063947 1 NC_008611.1 cytoplasmic protein; function unknown but has domain identity to UbiE, a methylase involved in ubiquinone/menaquinone biosynthesis; methylase 3063947 4552896 MUL_2739 Mycobacterium ulcerans Agy99 methylase YP_906521.1 3062991 D 362242 CDS YP_906522.1 118618190 4552898 3065334..3066116 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3066116 4552898 MUL_2742 Mycobacterium ulcerans Agy99 hypothetical protein YP_906522.1 3065334 D 362242 CDS YP_906523.1 118618191 4552899 complement(3066144..3068777) 1 NC_008611.1 cytoplasmic protein; involved in transcriptional mechanism.; LuxR family transcriptional regulator 3068777 4552899 MUL_2743 Mycobacterium ulcerans Agy99 LuxR family transcriptional regulator YP_906523.1 3066144 R 362242 CDS YP_906524.1 118618192 4552900 3068982..3070928 1 NC_008611.1 molecular chaperone; heat shock protein 90 3070928 htpG 4552900 htpG Mycobacterium ulcerans Agy99 heat shock protein 90 YP_906524.1 3068982 D 362242 CDS YP_906525.1 118618193 4552901 complement(3070929..3071900) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3071900 4552901 MUL_2745 Mycobacterium ulcerans Agy99 hypothetical protein YP_906525.1 3070929 R 362242 CDS YP_906526.1 118618194 4552902 complement(3072017..3072634) 1 NC_008611.1 cytoplasmic protein; probably involved in a transcriptional mechanism; TetR family transcriptional regulator 3072634 4552902 MUL_2746 Mycobacterium ulcerans Agy99 TetR family transcriptional regulator YP_906526.1 3072017 R 362242 CDS YP_906527.1 118618195 4552903 complement(3072866..3073051) 1 NC_008611.1 cytoplasmic protein; involved in the hydrocarbon hydroxylating system to convert conversion of dodecane to lauric acid, which transfers electrons from NADH to rubredoxin reductase and then through rubredoxin to alkane 1 monooxygenase.; rubredoxin RubB_1 3073051 rubB_1 4552903 rubB_1 Mycobacterium ulcerans Agy99 rubredoxin RubB_1 YP_906527.1 3072866 R 362242 CDS YP_906528.1 118618196 4552904 complement(3073053..3073223) 1 NC_008611.1 cytoplasmic protein; involved in the hydrocarbon hydroxylating system, which transfers electrons from NADH to rubredoxin reductase and then through rubredoxin to alkane 1 monooxygenase.; rubredoxin RubA_1 3073223 rubA_1 4552904 rubA_1 Mycobacterium ulcerans Agy99 rubredoxin RubA_1 YP_906528.1 3073053 R 362242 CDS YP_906529.1 118618197 4552905 complement(3073220..3074440) 1 NC_008611.1 membrane protein; thought to be involved in fatty acid metabolism. generates octanol and oxidized rubredoxin from octane and reduced rubredoxin. also hydroxylates fatty acids in the omega-position [catalytic activity: octane + reduced rubredoxin + (O)2 = 1-octanol + oxidized rubredoxin + H(2)O]; transmembrane alkane 1-monooxygenase AlkB_1 3074440 alkB_1 4552905 alkB_1 Mycobacterium ulcerans Agy99 transmembrane alkane 1-monooxygenase AlkB_1 YP_906529.1 3073220 R 362242 CDS YP_906530.1 118618198 4552907 complement(3076597..3077931) 1 NC_008611.1 cytoplasmic protein; required for the transposition of the insertion element IS2606; transposase for IS2606 3077931 4552907 MUL_2751 Mycobacterium ulcerans Agy99 transposase for IS2606 YP_906530.1 3076597 R 362242 CDS YP_906531.1 118618199 4552908 3078428..3079144 1 NC_008611.1 cytoplasmic protein; function unknown, probably involved in cellular metabolism, possibly electron transfer.; oxidoreductase 3079144 4552908 MUL_2753 Mycobacterium ulcerans Agy99 oxidoreductase YP_906531.1 3078428 D 362242 CDS YP_906532.1 118618200 4552909 3079392..3080012 1 NC_008611.1 cytoplasmic protein; cellular metabolism; oxidoreductase 3080012 4552909 MUL_2755 Mycobacterium ulcerans Agy99 oxidoreductase YP_906532.1 3079392 D 362242 CDS YP_906533.1 118618201 4552910 complement(3080026..3081054) 1 NC_008611.1 cytoplasmic protein; acyl-CoA dehydrogenase 3081054 4552910 MUL_2756 Mycobacterium ulcerans Agy99 acyl-CoA dehydrogenase YP_906533.1 3080026 R 362242 CDS YP_906534.1 118618202 4552911 complement(3081051..3082229) 1 NC_008611.1 cytoplasmic protein; acyl-CoA dehydrogenase 3082229 4552911 MUL_2757 Mycobacterium ulcerans Agy99 acyl-CoA dehydrogenase YP_906534.1 3081051 R 362242 CDS YP_906535.1 118618203 4552912 complement(3082229..3083026) 1 NC_008611.1 Also detected in the membrane fraction by proteomics.; cytoplasmic protein; oxidizes fatty acids using specific components (by similarity) [catalytic activity: (3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H(2)O]; enoyl-CoA hydratase, EchA8_5 3083026 echA8_5 4552912 echA8_5 Mycobacterium ulcerans Agy99 enoyl-CoA hydratase, EchA8_5 YP_906535.1 3082229 R 362242 CDS YP_906536.1 118618204 4552914 complement(3083950..3084438) 1 NC_008611.1 secreted protein; hypothetical protein 3084438 4552914 MUL_2761 Mycobacterium ulcerans Agy99 hypothetical protein YP_906536.1 3083950 R 362242 CDS YP_906537.1 118618205 4552915 complement(3084623..3085594) 1 NC_008611.1 cytoplasmic protein; involved in transcriptional mechanism.; IclR family transcriptional regulator 3085594 4552915 MUL_2762 Mycobacterium ulcerans Agy99 IclR family transcriptional regulator YP_906537.1 3084623 R 362242 CDS YP_906538.1 118618206 4552917 complement(3085932..3086537) 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; hypothetical protein 3086537 4552917 MUL_2763 Mycobacterium ulcerans Agy99 hypothetical protein YP_906538.1 3085932 R 362242 CDS YP_906539.1 118618207 4552919 complement(3087587..3088222) 1 NC_008611.1 cytoplasmic protein; methyltransferase (methylase) 3088222 4552919 MUL_2765 Mycobacterium ulcerans Agy99 methyltransferase (methylase) YP_906539.1 3087587 R 362242 CDS YP_906540.1 118618208 4552920 complement(3088219..3089151) 1 NC_008611.1 cytoplasmic protein; function unknown but high domain identity with O- Methyltransferases involved in polyketide biosynthesis; O-methyltransferase 3089151 4552920 MUL_2766 Mycobacterium ulcerans Agy99 O-methyltransferase YP_906540.1 3088219 R 362242 CDS YP_906541.1 118618209 4552921 3089265..3089681 1 NC_008611.1 membrane protein; hypothetical protein 3089681 4552921 MUL_2767 Mycobacterium ulcerans Agy99 hypothetical protein YP_906541.1 3089265 D 362242 CDS YP_906542.1 118618210 4552922 3089761..3090603 1 NC_008611.1 cytoplasmic protein; function unknown, but high domain identity with epimerases and phenazine biosynthesis-like protein, PhzC/PhzF which is involved in dimerisation of two 2,3- dihydro-3-oxo-anthranilic acid molecules to create Pca by P. fluorescens.; hypothetical protein 3090603 4552922 MUL_2768 Mycobacterium ulcerans Agy99 hypothetical protein YP_906542.1 3089761 D 362242 CDS YP_906543.1 118618211 4552923 complement(3090835..3092166) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3092166 4552923 MUL_2769 Mycobacterium ulcerans Agy99 hypothetical protein YP_906543.1 3090835 R 362242 CDS YP_906544.1 118618212 4552924 complement(3092159..3093346) 1 NC_008611.1 membrane protein; hypothetical protein 3093346 4552924 MUL_2770 Mycobacterium ulcerans Agy99 hypothetical protein YP_906544.1 3092159 R 362242 CDS YP_906545.1 118618213 4552926 3094565..3095197 1 NC_008611.1 secreted protein; function unknown but has ribonuclease I domain identity; hypothetical protein 3095197 4552926 MUL_2772 Mycobacterium ulcerans Agy99 hypothetical protein YP_906545.1 3094565 D 362242 CDS YP_906546.1 118618214 4552927 3095672..3096592 1 NC_008611.1 membrane protein; function unknown but domain identity with mechanosensitive ion channels; hypothetical protein 3096592 4552927 MUL_2773 Mycobacterium ulcerans Agy99 hypothetical protein YP_906546.1 3095672 D 362242 CDS YP_906547.1 118618215 4552928 complement(3096693..3099638) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS) Also detected in the cytoplasmic fraction by 2D-LC- MS/MS; membrane protein; function unknown but contains multiple functional domains including vWA domain (von willebrand factor (vWF) type a domain; found in extracellular proteins, like integrins, and mediates adhesion. also contains a vault protein inter-alpha-trypsin domain; hypothetical protein 3099638 4552928 MUL_2774 Mycobacterium ulcerans Agy99 hypothetical protein YP_906547.1 3096693 R 362242 CDS YP_906548.1 118618216 4552929 3099709..3100491 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3100491 4552929 MUL_2775 Mycobacterium ulcerans Agy99 hypothetical protein YP_906548.1 3099709 D 362242 CDS YP_906549.1 118618217 4552947 complement(3102481..3103527) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 3103527 4552947 MUL_2778 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_906549.1 3102481 R 362242 CDS YP_906550.1 118618218 4552949 3104935..3105666 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3105666 4552949 MUL_2781 Mycobacterium ulcerans Agy99 hypothetical protein YP_906550.1 3104935 D 362242 CDS YP_906551.1 118618219 4552950 3106065..3108242 1 NC_008611.1 cytoplasmic protein; function unknown but contains glutamine synthetase catalytic domain; hypothetical protein 3108242 4552950 MUL_2782 Mycobacterium ulcerans Agy99 hypothetical protein YP_906551.1 3106065 D 362242 CDS YP_906552.1 118618220 4552951 complement(3108511..3109791) 1 NC_008611.1 PE_PGRS39; membrane protein; PE-PGRS family protein 3109791 4552951 MUL_2783 Mycobacterium ulcerans Agy99 PE-PGRS family protein YP_906552.1 3108511 R 362242 CDS YP_906553.1 118618221 4552952 3110256..3110828 1 NC_008611.1 secreted protein; proline, glycine, valine-rich secreted protein 3110828 4552952 MUL_2784 Mycobacterium ulcerans Agy99 proline, glycine, valine-rich secreted protein YP_906553.1 3110256 D 362242 CDS YP_906554.1 118618222 4552954 3112125..3112883 1 NC_008611.1 cytoplasmic protein; function unknown, probably involved in cellular metabolism.; alanine rich hydrolase 3112883 4552954 MUL_2786 Mycobacterium ulcerans Agy99 alanine rich hydrolase YP_906554.1 3112125 D 362242 CDS YP_906555.1 118618223 4552955 complement(3112900..3114675) 1 NC_008611.1 membrane protein; function unknown. possibly transporter involved in transport of undeterminated substrate (possibly cationic amino acids) across the membrane: so responsible for the translocation of the substrate across the membrane.; hypothetical protein 3114675 4552955 MUL_2787 Mycobacterium ulcerans Agy99 hypothetical protein YP_906555.1 3112900 R 362242 CDS YP_906556.1 118618224 4552956 complement(3114759..3115976) 1 NC_008611.1 cytoplasmic protein; function unknown, high domain identity with saccharopine dehydrogenase. this family comprises three structural domains that can not be separated in the linear sequence. in some organisms this enzyme is found as a bifunctional polypeptide with lysine ketoglutarate.; saccharopine dehydrogenase 3115976 4552956 MUL_2788 Mycobacterium ulcerans Agy99 saccharopine dehydrogenase YP_906556.1 3114759 R 362242 CDS YP_906557.1 118618225 4552957 complement(3116266..3117756) 1 NC_008611.1 catalyzes the formation of 4-aminobutanoate from 4-aminobutanal; involved in putrescine degradation; gamma-aminobutyraldehyde dehydrogenase 3117756 4552957 MUL_2789 Mycobacterium ulcerans Agy99 gamma-aminobutyraldehyde dehydrogenase YP_906557.1 3116266 R 362242 CDS YP_906558.1 118618226 4552958 3118064..3118393 1 NC_008611.1 cytoplasmic protein; involved in transcriptional mechanism.; Lrp/AsnC family transcriptional regulator 3118393 4552958 MUL_2790 Mycobacterium ulcerans Agy99 Lrp/AsnC family transcriptional regulator YP_906558.1 3118064 D 362242 CDS YP_906559.1 118618227 4552959 3118390..3119745 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS. Also detected in the membrane fraction by proteomics (2D-LC-MS/MS); membrane protein; function unknown, high domain identity with BioA, aminotransferase [coenzyme metabolism]; hypothetical protein 3119745 4552959 MUL_2791 Mycobacterium ulcerans Agy99 hypothetical protein YP_906559.1 3118390 D 362242 CDS YP_906560.1 118618228 4552960 complement(3119720..3120700) 1 NC_008611.1 cytoplasmic protein; function unknown - possible oxidoreducatse; hypothetical protein 3120700 4552960 MUL_2792 Mycobacterium ulcerans Agy99 hypothetical protein YP_906560.1 3119720 R 362242 CDS YP_906561.1 118618229 4552961 complement(3120805..3121371) 1 NC_008611.1 cytoplasmic protein; possibly involved in transcriptional mechanism.; transcriptional regulatory protein 3121371 4552961 MUL_2793 Mycobacterium ulcerans Agy99 transcriptional regulatory protein YP_906561.1 3120805 R 362242 CDS YP_906562.1 118618230 4552962 3121486..3122331 1 NC_008611.1 function unknown, probably involved in cellular metabolism; short chain dehydrogenase 3122331 4552962 MUL_2794 Mycobacterium ulcerans Agy99 short chain dehydrogenase YP_906562.1 3121486 D 362242 CDS YP_906563.1 118618231 4552963 3122362..3122790 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3122790 4552963 MUL_2795 Mycobacterium ulcerans Agy99 hypothetical protein YP_906563.1 3122362 D 362242 CDS YP_906564.1 118618232 4552964 complement(3122787..3123215) 1 NC_008611.1 cytoplasmic protein; rifampin ADP-ribosyl transferase 3123215 4552964 MUL_2796 Mycobacterium ulcerans Agy99 rifampin ADP-ribosyl transferase YP_906564.1 3122787 R 362242 CDS YP_906565.1 118618233 4552965 complement(3123217..3124440) 1 NC_008611.1 cytoplasmic protein; catalyzes the one electron reduction of certain quinones [catalytic activity: NADPH + quinone = NADP+ + semiquinone]; quinone reductase, Qor_1 3124440 qor_1 4552965 qor_1 Mycobacterium ulcerans Agy99 quinone reductase, Qor_1 YP_906565.1 3123217 R 362242 CDS YP_906566.1 118618234 4552966 3124478..3125914 1 NC_008611.1 membrane protein; hydrolyzes a monocarboxylic acid amide and generates a monocarboxylate [catalytic activity: a monocarboxylic acid amide + H(2)O = a monocarboxylate + NH(3)]; amidase AmiC_1 3125914 amiC_1 4552966 amiC_1 Mycobacterium ulcerans Agy99 amidase AmiC_1 YP_906566.1 3124478 D 362242 CDS YP_906567.1 118618235 4552967 complement(3125957..3127492) 1 NC_008611.1 membrane protein; hydrolyzes sphingomyelin in addition to phosphatidylcholine. probable virulence factor implicated in the pathogenesis of mycobacterium tuberculosis at the level of intracellular survival, by the alteration of cell signaling events or by direct cytotoxicity [catalytic activity: a phosphatidylcholine + H(2)O = 1,2- diacylglycerol + choline phosphate]; membrane-associated phospholipase C 2 PlcB 3127492 plcB 4552967 plcB Mycobacterium ulcerans Agy99 membrane-associated phospholipase C 2 PlcB YP_906567.1 3125957 R 362242 CDS YP_906568.1 118618236 4552970 complement(3129318..3130121) 1 NC_008611.1 cytoplasmic protein; function unknown but domain identity with streptomyces scabies esterase protein; hydrolase 3130121 4552970 MUL_2802 Mycobacterium ulcerans Agy99 hydrolase YP_906568.1 3129318 R 362242 CDS YP_906569.1 118618237 4552971 complement(3130118..3130912) 1 NC_008611.1 functions in thiamine (vitamin B1) biosynthesis; in Bacillus subtilis this enzyme catalyzes the formation of thiazole from dehydroxyglycine and 1-deoxy-D-xylulose-5-phosphate and ThiS-thiocarboxylate; thiazole synthase 3130912 thiG 4552971 thiG Mycobacterium ulcerans Agy99 thiazole synthase YP_906569.1 3130118 R 362242 CDS YP_906570.1 118618238 4552972 complement(3130905..3131102) 1 NC_008611.1 cytoplasmic protein; part of the thiamine biosynthesis operon. ThiS (thiamins) is a 66 aa protein involved in sulphur transfer. this is coded in the thiCEFSGH operon in E. coli.; thiamine biosynthesis protein ThiS 3131102 thiS 4552972 thiS Mycobacterium ulcerans Agy99 thiamine biosynthesis protein ThiS YP_906570.1 3130905 R 362242 CDS YP_906571.1 118618239 4552973 complement(3131099..3132118) 1 NC_008611.1 membrane protein; involved in thiamine biosynthesis.; thiamine biosynthesis oxidoreductase ThiO 3132118 thiO 4552973 thiO Mycobacterium ulcerans Agy99 thiamine biosynthesis oxidoreductase ThiO YP_906571.1 3131099 R 362242 CDS YP_906572.1 118618240 4552974 3132280..3132942 1 NC_008611.1 Condenses 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate to form thiamine monophosphate; thiamine-phosphate pyrophosphorylase 3132942 thiE 4552974 thiE Mycobacterium ulcerans Agy99 thiamine-phosphate pyrophosphorylase YP_906572.1 3132280 D 362242 CDS YP_906573.1 118618241 4552975 complement(3132914..3133537) 1 NC_008611.1 cytoplasmic protein; possibly involved in the go system responsible for removing an oxidatively damaged form of guanine (7,8- dihydro-8-oxoguanine) from DNA and the nucleotide pool. 8- oxo-dGTP is inserted opposite da and dc residues of template DNA with almost equal efficiency thus leading to a.T to G.C transversions. MutT specifically degrades 8-oxo- dGTP to the monophosphate [catalytic activity: 8-oxo-dGTP + H2O = 8-oxo-DGMP + pyrophosphate]; mutator protein MutT3 3133537 mutT3 4552975 mutT3 Mycobacterium ulcerans Agy99 mutator protein MutT3 YP_906573.1 3132914 R 362242 CDS YP_906574.1 118618242 4552976 3133689..3135008 1 NC_008611.1 membrane protein; hypothetical protein 3135008 4552976 MUL_2808 Mycobacterium ulcerans Agy99 hypothetical protein YP_906574.1 3133689 D 362242 CDS YP_906575.1 118618243 4552977 3135008..3135994 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; involved in active transport of glutamine across the membrane (import) interacts with the glutamine- transport system.; glutamine-binding lipoprotein GlnH 3135994 glnH 4552977 glnH Mycobacterium ulcerans Agy99 glutamine-binding lipoprotein GlnH YP_906575.1 3135008 D 362242 CDS YP_906576.1 118618244 4552978 3136099..3138297 1 NC_008611.1 Detected in the secreted protein fraction by proteomics.; membrane protein; involved in signal transduction (via phosphorylation) thought to regulate amino-acid uptake and stationary-phase metabolism. phosphorylates the peptide substrate myelin basic protein (MBP) at serine residues [catalytic activity: ATP + a protein = ADP + a P; serine/threonine-protein kinase PknG 3138297 pknG 4552978 pknG Mycobacterium ulcerans Agy99 serine/threonine-protein kinase PknG YP_906576.1 3136099 D 362242 CDS YP_906577.1 118618245 4552979 complement(3138422..3139282) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3139282 4552979 MUL_2811 Mycobacterium ulcerans Agy99 hypothetical protein YP_906577.1 3138422 R 362242 CDS YP_906578.1 118618246 4552980 complement(3139461..3140600) 1 NC_008611.1 AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA; acetate kinase 3140600 ackA 4552980 ackA Mycobacterium ulcerans Agy99 acetate kinase YP_906578.1 3139461 R 362242 CDS YP_906579.1 118618247 4552982 complement(3142710..3143720) 1 NC_008611.1 cytoplasmic protein; catalyzes oxidation of glucose-6-phosphate to 6- phosphogluconolactone using coenzyme F420 (an *-hydroxy-5- deazaflavin derivative) as the electron acceptor.; F420-dependent glucose-6-phosphate dehydrogenase Fgd1 3143720 fgd1 4552982 fgd1 Mycobacterium ulcerans Agy99 F420-dependent glucose-6-phosphate dehydrogenase Fgd1 YP_906579.1 3142710 R 362242 CDS YP_906580.1 118618248 4552983 3143802..3144554 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; beta lactamase-like protein 3144554 4552983 MUL_2815 Mycobacterium ulcerans Agy99 beta lactamase-like protein YP_906580.1 3143802 D 362242 CDS YP_906581.1 118618249 4552989 complement(3150532..3151578) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 3151578 4552989 MUL_2821 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_906581.1 3150532 R 362242 CDS YP_906582.1 118618250 4552991 complement(3152758..3153264) 1 NC_008611.1 cytoplasmic protein; function unknown but has domain identity with acetyltransferases; hypothetical protein 3153264 4552991 MUL_2823 Mycobacterium ulcerans Agy99 hypothetical protein YP_906582.1 3152758 R 362242 CDS YP_906583.1 118618251 4552992 complement(3153438..3153818) 1 NC_008611.1 membrane protein; hypothetical protein 3153818 4552992 MUL_2824 Mycobacterium ulcerans Agy99 hypothetical protein YP_906583.1 3153438 R 362242 CDS YP_906584.1 118618252 4552993 3153854..3155041 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; function unknown, but involved in lipid degradation.; acyl-CoA dehydrogenase FadE7 3155041 fadE7 4552993 fadE7 Mycobacterium ulcerans Agy99 acyl-CoA dehydrogenase FadE7 YP_906584.1 3153854 D 362242 CDS YP_906585.1 118618253 4552995 3156266..3157600 1 NC_008611.1 cytoplasmic protein; required for the transposition of the insertion element IS2606.; transposase for IS2606 3157600 4552995 MUL_2827 Mycobacterium ulcerans Agy99 transposase for IS2606 YP_906585.1 3156266 D 362242 CDS YP_906586.1 118618254 4552996 complement(3157724..3158770) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 3158770 4552996 MUL_2828 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_906586.1 3157724 R 362242 CDS YP_906587.1 118618255 4552998 3159790..3159897 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3159897 4552998 MUL_2830 Mycobacterium ulcerans Agy99 hypothetical protein YP_906587.1 3159790 D 362242 CDS YP_906588.1 118618256 4552999 3160003..3160281 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3160281 4552999 MUL_2831 Mycobacterium ulcerans Agy99 hypothetical protein YP_906588.1 3160003 D 362242 CDS YP_906589.1 118618257 4553016 3160374..3161438 1 NC_008611.1 Part of a 2158bp section not present in M. marinum M strain. However LipU orthologs are found in MTB and M. avium paratb; membrane protein; function unknown but probably involved in lipid hydrolysis; lipase LipU_1 3161438 lipU_1 4553016 lipU_1 Mycobacterium ulcerans Agy99 lipase LipU_1 YP_906589.1 3160374 D 362242 CDS YP_906590.1 118618258 4553017 complement(3161464..3162093) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3162093 4553017 MUL_2833 Mycobacterium ulcerans Agy99 hypothetical protein YP_906590.1 3161464 R 362242 CDS YP_906591.1 118618259 4553018 complement(3162090..3163388) 1 NC_008611.1 catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis; adenylosuccinate synthetase 3163388 purA 4553018 purA Mycobacterium ulcerans Agy99 adenylosuccinate synthetase YP_906591.1 3162090 R 362242 CDS YP_906592.1 118618260 4553019 3163479..3164156 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3164156 4553019 MUL_2835 Mycobacterium ulcerans Agy99 hypothetical protein YP_906592.1 3163479 D 362242 CDS YP_906593.1 118618261 4553020 3164167..3164946 1 NC_008611.1 membrane protein; hypothetical protein 3164946 4553020 MUL_2836 Mycobacterium ulcerans Agy99 hypothetical protein YP_906593.1 3164167 D 362242 CDS YP_906594.1 118618262 4553021 3164991..3165914 1 NC_008611.1 membrane protein; function unknown, possibly involved in transport of metal ions across the membrane.; efflux membrane protein 3165914 4553021 MUL_2837 Mycobacterium ulcerans Agy99 efflux membrane protein YP_906594.1 3164991 D 362242 CDS YP_906595.1 118618263 4553022 complement(3165944..3166918) 1 NC_008611.1 cytoplasmic protein; involved in sulfation: activity towards typical ceramide glycolipids and trehalose glycolipids.; glycolipid sulfotransferase 3166918 4553022 MUL_2838 Mycobacterium ulcerans Agy99 glycolipid sulfotransferase YP_906595.1 3165944 R 362242 CDS YP_906596.1 118618264 4553023 complement(3166919..3167056) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3167056 4553023 MUL_5105 Mycobacterium ulcerans Agy99 hypothetical protein YP_906596.1 3166919 R 362242 CDS YP_906597.1 118618265 4553024 complement(3167060..3167314) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3167314 4553024 MUL_2839 Mycobacterium ulcerans Agy99 hypothetical protein YP_906597.1 3167060 R 362242 CDS YP_906598.1 118618266 4553025 complement(3167335..3168093) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3168093 4553025 MUL_2840 Mycobacterium ulcerans Agy99 hypothetical protein YP_906598.1 3167335 R 362242 CDS YP_906599.1 118618267 4553026 complement(3168317..3168739) 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; hypothetical protein 3168739 4553026 MUL_2841 Mycobacterium ulcerans Agy99 hypothetical protein YP_906599.1 3168317 R 362242 CDS YP_906600.1 118618268 4553027 3168881..3169696 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS) Also detected in the cytoplasmic fraction by 2D-LC- MS/MS.; membrane protein; hypothetical protein 3169696 4553027 MUL_2842 Mycobacterium ulcerans Agy99 hypothetical protein YP_906600.1 3168881 D 362242 CDS YP_906601.1 118618269 4553028 complement(3169801..3170475) 1 NC_008611.1 cytoplasmic protein; could be involved in biotin biosynthesis (at the first step) [catalytic activity: 6-carboxyhexanoyl-CoA + L- alanine = 8-amino-7-oxononanoate + CoA + CO2]; 8-amino-7-oxononanoate synthase BioF2_3 3170475 bioF2_3 4553028 bioF2_3 Mycobacterium ulcerans Agy99 8-amino-7-oxononanoate synthase BioF2_3 YP_906601.1 3169801 R 362242 CDS YP_906602.1 118618270 4553029 complement(3170669..3171715) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 3171715 4553029 MUL_2844 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_906602.1 3170669 R 362242 CDS YP_906603.1 118618271 4553031 complement(3174525..3175073) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3175073 4553031 MUL_2846 Mycobacterium ulcerans Agy99 hypothetical protein YP_906603.1 3174525 R 362242 CDS YP_906604.1 118618272 4553032 complement(3175082..3175687) 1 NC_008611.1 cytoplasmic protein; GTP/ATP-binding protein 3175687 4553032 MUL_2847 Mycobacterium ulcerans Agy99 GTP/ATP-binding protein YP_906604.1 3175082 R 362242 CDS YP_906605.1 118618273 4553033 complement(3175668..3175943) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3175943 4553033 MUL_2848 Mycobacterium ulcerans Agy99 hypothetical protein YP_906605.1 3175668 R 362242 CDS YP_906606.1 118618274 4553034 complement(3176030..3176461) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3176461 4553034 MUL_2849 Mycobacterium ulcerans Agy99 hypothetical protein YP_906606.1 3176030 R 362242 CDS YP_906607.1 118618275 4553035 complement(3176458..3179193) 1 NC_008611.1 membrane protein; function unknown but may be a regulatory protein as it contains a signal transduction histidine kinase domain; putative regultory protein 3179193 4553035 MUL_2850 Mycobacterium ulcerans Agy99 putative regultory protein YP_906607.1 3176458 R 362242 CDS YP_906608.1 118618276 4553036 complement(3179410..3180015) 1 NC_008611.1 cytoplasmic protein; function unknown but may be involved in RNA methylation; methyltransferase 3180015 4553036 MUL_2851 Mycobacterium ulcerans Agy99 methyltransferase YP_906608.1 3179410 R 362242 CDS YP_906609.1 118618277 4553037 3180083..3180547 1 NC_008611.1 cytoplasmic protein; involved in rRNA methylation; tRNA/rRNA methyltransferase SpoU 3180547 spoU 4553037 spoU Mycobacterium ulcerans Agy99 tRNA/rRNA methyltransferase SpoU YP_906609.1 3180083 D 362242 CDS YP_906610.1 118618278 4553038 3180728..3181936 1 NC_008611.1 PE_PGRS51; membrane protein; PE-PGRS family protein 3181936 4553038 MUL_2853 Mycobacterium ulcerans Agy99 PE-PGRS family protein YP_906610.1 3180728 D 362242 CDS YP_906611.1 118618279 4553039 complement(3181948..3182592) 1 NC_008611.1 Detected in the membrane fraction by proteomics (2D- LC-MS/MS); cytoplasmic protein; function unknown, probably involved in cellular metabolism; nitroreductase 3182592 4553039 MUL_2854 Mycobacterium ulcerans Agy99 nitroreductase YP_906611.1 3181948 R 362242 CDS YP_906612.1 118618280 4553040 3182933..3183979 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 3183979 4553040 MUL_2855 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_906612.1 3182933 D 362242 CDS YP_906613.1 118618281 4553042 complement(3184204..3184521) 1 NC_008611.1 hypothetical protein 3184521 4553042 MUL_2856 Mycobacterium ulcerans Agy99 hypothetical protein YP_906613.1 3184204 R 362242 CDS YP_906614.1 118618282 4553043 complement(3184630..3184899) 1 NC_008611.1 cytoplasmic protein; this protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.; iron-regulated elongation factor Tu Tuf-like 3184899 4553043 MUL_2857 Mycobacterium ulcerans Agy99 iron-regulated elongation factor Tu Tuf-like YP_906614.1 3184630 R 362242 CDS YP_906615.1 118618283 4553044 3184889..3185332 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3185332 4553044 MUL_2858 Mycobacterium ulcerans Agy99 hypothetical protein YP_906615.1 3184889 D 362242 CDS YP_906616.1 118618284 4553046 complement(3186250..3187296) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 3187296 4553046 MUL_2860 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_906616.1 3186250 R 362242 CDS YP_906617.1 118618285 4553047 complement(3187661..3187948) 1 NC_008611.1 hypothetical protein 3187948 4553047 MUL_2861 Mycobacterium ulcerans Agy99 hypothetical protein YP_906617.1 3187661 R 362242 CDS YP_906618.1 118618286 4553049 complement(3188463..3188753) 1 NC_008611.1 cytoplasmic protein; function unknown, probably involved in cellular metabolism; oxidoreductase 3188753 4553049 MUL_2862 Mycobacterium ulcerans Agy99 oxidoreductase YP_906618.1 3188463 R 362242 CDS YP_906619.1 118618287 4553095 complement(3188834..3189406) 1 NC_008611.1 membrane protein; Mce associated membrane protein 3189406 4553095 MUL_2863 Mycobacterium ulcerans Agy99 Mce associated membrane protein YP_906619.1 3188834 R 362242 CDS YP_906620.1 118618288 4553096 complement(3189403..3189966) 1 NC_008611.1 membrane protein; Mce associated membrane protein 3189966 4553096 MUL_2864 Mycobacterium ulcerans Agy99 Mce associated membrane protein YP_906620.1 3189403 R 362242 CDS YP_906621.1 118618289 4553097 complement(3190010..3191473) 1 NC_008611.1 membrane protein; function unknown, but thought involved in host cell invasion.; MCE-family protein Mce3F 3191473 mce3F 4553097 mce3F Mycobacterium ulcerans Agy99 MCE-family protein Mce3F YP_906621.1 3190010 R 362242 CDS YP_906622.1 118618290 4553098 complement(3191474..3192643) 1 NC_008611.1 membrane protein; function unknown, but thought to be involved in host cell invasion.; MCE family lipoprotein LprM 3192643 lprM 4553098 lprM Mycobacterium ulcerans Agy99 MCE family lipoprotein LprM YP_906622.1 3191474 R 362242 CDS YP_906623.1 118618291 4553099 complement(3192643..3193926) 1 NC_008611.1 membrane protein; function unknown, but thought to be involved in host cell invasion.; MCE-family protein Mce3D 3193926 mce3D 4553099 mce3D Mycobacterium ulcerans Agy99 MCE-family protein Mce3D YP_906623.1 3192643 R 362242 CDS YP_906624.1 118618292 4553101 complement(3195203..3196231) 1 NC_008611.1 membrane protein; function unknown, but thought to be involved in host cell invasion.; MCE-family protein Mce3B 3196231 mce3B 4553101 mce3B Mycobacterium ulcerans Agy99 MCE-family protein Mce3B YP_906624.1 3195203 R 362242 CDS YP_906625.1 118618293 4553103 complement(3197697..3198389) 1 NC_008611.1 membrane protein; function unknown, but probably part of Mce3 operon and member of YrbE family; integral membrane protein, Yrb3B 3198389 yrb3B 4553103 yrb3B Mycobacterium ulcerans Agy99 integral membrane protein, Yrb3B YP_906625.1 3197697 R 362242 CDS YP_906626.1 118618294 4553104 complement(3198561..3199394) 1 NC_008611.1 membrane protein; integral membrane protein YrbE3A 3199394 yrbE3A 4553104 yrbE3A Mycobacterium ulcerans Agy99 integral membrane protein YrbE3A YP_906626.1 3198561 R 362242 CDS YP_906627.1 118618295 4553105 complement(3199719..3199913) 1 NC_008611.1 cytoplasmic protein; ferredoxin 3199913 4553105 MUL_2873 Mycobacterium ulcerans Agy99 ferredoxin YP_906627.1 3199719 R 362242 CDS YP_906628.1 118618296 4553106 complement(3199910..3200266) 1 NC_008611.1 cytoplasmic protein; function unknown, domain identity with ketosteroid isomerase-related proteins; hypothetical protein 3200266 4553106 MUL_2874 Mycobacterium ulcerans Agy99 hypothetical protein YP_906628.1 3199910 R 362242 CDS YP_906629.1 118618297 4553108 3201681..3202916 1 NC_008611.1 cytoplasmic protein; function unknown but weak domain identity with two- component response regulators; putative regulatory protein 3202916 4553108 MUL_2876 Mycobacterium ulcerans Agy99 putative regulatory protein YP_906629.1 3201681 D 362242 CDS YP_906630.1 118618298 4553109 complement(3202919..3204442) 1 NC_008611.1 cytoplasmic protein; thought to oxidize a wide variety of aliphatic and aromatic aldehydes.; aldehyde dehydrogenase 3204442 4553109 MUL_2877 Mycobacterium ulcerans Agy99 aldehyde dehydrogenase YP_906630.1 3202919 R 362242 CDS YP_906631.1 118618299 4553110 complement(3204439..3204858) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3204858 4553110 MUL_2878 Mycobacterium ulcerans Agy99 hypothetical protein YP_906631.1 3204439 R 362242 CDS YP_906632.1 118618300 4553111 3205341..3206543 1 NC_008611.1 cytoplasmic protein; involved in transcriptional mechanism; repression of the Mce3 operon. could also have a regulatory action on the Mce2 operon.; TetR family transcriptional regulator 3206543 mce3R 4553111 mce3R Mycobacterium ulcerans Agy99 TetR family transcriptional regulator YP_906632.1 3205341 D 362242 CDS YP_906633.1 118618301 4553112 complement(3206870..3207232) 1 NC_008611.1 membrane protein; maybe required for the translocation of the substrate across the membrane.; multidrugs-transport integral membrane protein Mmr-like 3207232 4553112 MUL_2881 Mycobacterium ulcerans Agy99 multidrugs-transport integral membrane protein Mmr-like YP_906633.1 3206870 R 362242 CDS YP_906634.1 118618302 4553113 complement(3207567..3207887) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3207887 4553113 MUL_2882 Mycobacterium ulcerans Agy99 hypothetical protein YP_906634.1 3207567 R 362242 CDS YP_906635.1 118618303 4553314 complement(3208993..3209763) 1 NC_008611.1 function unknown, probably involved in cellular metabolism; short-chain type dehydrogenase/reductase 3209763 4553314 MUL_2885 Mycobacterium ulcerans Agy99 short-chain type dehydrogenase/reductase YP_906635.1 3208993 R 362242 CDS YP_906636.1 118618304 4553315 complement(3209767..3210864) 1 NC_008611.1 cytoplasmic protein; involved in riboflavin biosynthesis [catalytic activity : GTP + 3 H(2)O = formate + 2,5-diamino-6-hydroxy- 4-(5-phosphoribosylamino)pyrimidine + diphosphate]; riboflavin biosynthesis protein RibA1 3210864 ribA1 4553315 ribA1 Mycobacterium ulcerans Agy99 riboflavin biosynthesis protein RibA1 YP_906636.1 3209767 R 362242 CDS YP_906637.1 118618305 4553316 complement(3210861..3211394) 1 NC_008611.1 cytoplasmic protein; function unknown, probably involved in cellular metabolism; oxidoreducatse 3211394 4553316 MUL_2887 Mycobacterium ulcerans Agy99 oxidoreducatse YP_906637.1 3210861 R 362242 CDS YP_906638.1 118618306 4553317 complement(3211391..3212446) 1 NC_008611.1 cytoplasmic protein; this enzyme acts on epoxides (alkene oxides, oxiranes) and Arene oxides. plays a role in xenobiotic metabolism by degrading potential toxic epoxides. also determines steady-state levels of physiological mediators.; epoxide hydrolase EphB 3212446 ephB 4553317 ephB Mycobacterium ulcerans Agy99 epoxide hydrolase EphB YP_906638.1 3211391 R 362242 CDS YP_906639.1 118618307 4553318 complement(3212458..3214977) 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; function unknown, may be involved in electron transfer.; oxygenase 3214977 4553318 MUL_2889 Mycobacterium ulcerans Agy99 oxygenase YP_906639.1 3212458 R 362242 CDS YP_906640.1 118618308 4553319 complement(3215005..3216141) 1 NC_008611.1 cytoplasmic protein; function unknown, probably involved in cellular metabolism; oxygenase 3216141 4553319 MUL_2890 Mycobacterium ulcerans Agy99 oxygenase YP_906640.1 3215005 R 362242 CDS YP_906641.1 118618309 4553321 3217401..3218573 1 NC_008611.1 cytoplasmic protein; function unknown, but supposed involvement in lipid degradation.; acyl-CoA dehydrogenase FadE17 3218573 fadE17 4553321 fadE17 Mycobacterium ulcerans Agy99 acyl-CoA dehydrogenase FadE17 YP_906641.1 3217401 D 362242 CDS YP_906642.1 118618310 4553322 3218575..3219663 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; function unknown, but supposed involvement in lipid degradation.; acyl-CoA dehydrogenase FadE18 3219663 fadE18 4553322 fadE18 Mycobacterium ulcerans Agy99 acyl-CoA dehydrogenase FadE18 YP_906642.1 3218575 D 362242 CDS YP_906643.1 118618311 4553323 complement(3219685..3220182) 1 NC_008611.1 antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein; thiol peroxidase 3220182 tpx 4553323 tpx Mycobacterium ulcerans Agy99 thiol peroxidase YP_906643.1 3219685 R 362242 CDS YP_906644.1 118618312 4553324 complement(3220328..3221371) 1 NC_008611.1 cytoplasmic protein; function unknown but domain identity with Fe-S oxidoreductases; oxidoreductase 3221371 4553324 MUL_2895 Mycobacterium ulcerans Agy99 oxidoreductase YP_906644.1 3220328 R 362242 CDS YP_906645.1 118618313 4553325 complement(3221415..3222461) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 3222461 4553325 MUL_2896 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_906645.1 3221415 R 362242 CDS YP_906646.1 118618314 4553327 complement(3223035..3224369) 1 NC_008611.1 cytoplasmic protein; required for the transposition of the insertion element IS2606; transposase for IS2606 3224369 4553327 MUL_2898 Mycobacterium ulcerans Agy99 transposase for IS2606 YP_906646.1 3223035 R 362242 CDS YP_906647.1 118618315 4553328 complement(3224436..3224819) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3224819 4553328 MUL_5111 Mycobacterium ulcerans Agy99 hypothetical protein YP_906647.1 3224436 R 362242 CDS YP_906648.1 118618316 4553330 3226070..3227116 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 3227116 4553330 MUL_2901 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_906648.1 3226070 D 362242 CDS YP_906649.1 118618317 4553331 3228220..3229170 1 NC_008611.1 cytoplasmic protein; involved in transcriptional mechanism; transcriptional regulatory protein 3229170 4553331 MUL_2902 Mycobacterium ulcerans Agy99 transcriptional regulatory protein YP_906649.1 3228220 D 362242 CDS YP_906650.1 118618318 4553333 complement(3229990..3230454) 1 NC_008611.1 membrane protein; hypothetical protein 3230454 4553333 MUL_2904 Mycobacterium ulcerans Agy99 hypothetical protein YP_906650.1 3229990 R 362242 CDS YP_906651.1 118618319 4553334 3230552..3231112 1 NC_008611.1 cytoplasmic protein; function unknown but contains dihydrofolate reductase domain; hypothetical protein 3231112 4553334 MUL_2905 Mycobacterium ulcerans Agy99 hypothetical protein YP_906651.1 3230552 D 362242 CDS YP_906652.1 118618320 4553335 complement(3231143..3232027) 1 NC_008611.1 cytoplasmic protein; function unknown but has weak indentity with hydrolase domains; hypothetical protein 3232027 4553335 MUL_2906 Mycobacterium ulcerans Agy99 hypothetical protein YP_906652.1 3231143 R 362242 CDS YP_906653.1 118618321 4553336 complement(3232029..3232505) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3232505 4553336 MUL_2907 Mycobacterium ulcerans Agy99 hypothetical protein YP_906653.1 3232029 R 362242 CDS YP_906654.1 118618322 4553338 complement(3233381..3234154) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3234154 4553338 MUL_2909 Mycobacterium ulcerans Agy99 hypothetical protein YP_906654.1 3233381 R 362242 CDS YP_906655.1 118618323 4553339 complement(3234251..3234664) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3234664 4553339 MUL_2910 Mycobacterium ulcerans Agy99 hypothetical protein YP_906655.1 3234251 R 362242 CDS YP_906656.1 118618324 4553340 complement(3234735..3236204) 1 NC_008611.1 cytoplasmic protein; function unknown: involved in carbohydrate transport and metabolism; alpha-L-fucosidase 3236204 4553340 MUL_2911 Mycobacterium ulcerans Agy99 alpha-L-fucosidase YP_906656.1 3234735 R 362242 CDS YP_906657.1 118618325 4553341 3236418..3236966 1 NC_008611.1 cytoplasmic protein; involved in oxidative stress response.; alkyl hydroperoxide reductase C protein AhpC_1 3236966 ahpC_1 4553341 ahpC_1 Mycobacterium ulcerans Agy99 alkyl hydroperoxide reductase C protein AhpC_1 YP_906657.1 3236418 D 362242 CDS YP_906658.1 118618326 4553342 complement(3236963..3238297) 1 NC_008611.1 cytoplasmic protein; required for the transposition of the insertion element IS2606; transposase for IS2606 3238297 4553342 MUL_2913 Mycobacterium ulcerans Agy99 transposase for IS2606 YP_906658.1 3236963 R 362242 CDS YP_906659.1 118618327 4553343 complement(3238991..3240355) 1 NC_008611.1 catalyzes the transformation of hydroxyatrazine to N-isopropylammelide and ethylamine in the atrazine degradation pathway.; hydroxydechloroatrazine ethylaminohydrolase 3240355 4553343 MUL_2914 Mycobacterium ulcerans Agy99 hydroxydechloroatrazine ethylaminohydrolase YP_906659.1 3238991 R 362242 CDS YP_906660.1 118618328 4553344 3240788..3241834 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 3241834 4553344 MUL_2915 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_906660.1 3240788 D 362242 CDS YP_906661.1 118618329 4553345 3241943..3242422 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3242422 4553345 MUL_2916 Mycobacterium ulcerans Agy99 hypothetical protein YP_906661.1 3241943 D 362242 CDS YP_906662.1 118618330 4553346 3242562..3243140 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3243140 4553346 MUL_2917 Mycobacterium ulcerans Agy99 hypothetical protein YP_906662.1 3242562 D 362242 CDS YP_906663.1 118618331 4553348 complement(3245086..3246960) 1 NC_008611.1 activates fatty acids by binding to coenzyme A; putative fatty-acid--CoA ligase 3246960 fadD31 4553348 fadD31 Mycobacterium ulcerans Agy99 putative fatty-acid--CoA ligase YP_906663.1 3245086 R 362242 CDS YP_906664.1 118618332 4553350 3248100..3248624 1 NC_008611.1 cytoplasmic protein; involved in transcriptional mechanism.; TetR family transcriptional regulator 3248624 4553350 MUL_2922 Mycobacterium ulcerans Agy99 TetR family transcriptional regulator YP_906664.1 3248100 D 362242 CDS YP_906665.1 118618333 4553352 3248804..3249205 1 NC_008611.1 membrane protein; hypothetical protein 3249205 4553352 MUL_2924 Mycobacterium ulcerans Agy99 hypothetical protein YP_906665.1 3248804 D 362242 CDS YP_906666.1 118618334 4553353 3249499..3249930 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3249930 4553353 MUL_2925 Mycobacterium ulcerans Agy99 hypothetical protein YP_906666.1 3249499 D 362242 CDS YP_906667.1 118618335 4553354 complement(3249945..3250928) 1 NC_008611.1 cytoplasmic protein; wide specificity for D-amino acids. also acts on glycine [catalytic activity: a D-amino acid + H2O + O2 = a 2-oxo acid + NH3 + H2O2]; D-amino acid oxidase Aao 3250928 aao 4553354 aao Mycobacterium ulcerans Agy99 D-amino acid oxidase Aao YP_906667.1 3249945 R 362242 CDS YP_906668.1 118618336 4553355 complement(3250941..3251408) 1 NC_008611.1 membrane protein; hypothetical protein 3251408 4553355 MUL_2927 Mycobacterium ulcerans Agy99 hypothetical protein YP_906668.1 3250941 R 362242 CDS YP_906669.1 118618337 4553356 complement(3251457..3251834) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3251834 4553356 MUL_2928 Mycobacterium ulcerans Agy99 hypothetical protein YP_906669.1 3251457 R 362242 CDS YP_906670.1 118618338 4553357 complement(3251870..3252595) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3252595 4553357 MUL_2929 Mycobacterium ulcerans Agy99 hypothetical protein YP_906670.1 3251870 R 362242 CDS YP_906671.1 118618339 4553358 3253335..3254381 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 3254381 4553358 MUL_2930 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_906671.1 3253335 D 362242 CDS YP_906672.1 118618340 4553359 complement(3254347..3254637) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3254637 4553359 MUL_2931 Mycobacterium ulcerans Agy99 hypothetical protein YP_906672.1 3254347 R 362242 CDS YP_906673.1 118618341 4553360 complement(3254728..3255975) 1 NC_008611.1 membrane protein; PPE family protein 3255975 4553360 MUL_2932 Mycobacterium ulcerans Agy99 PPE family protein YP_906673.1 3254728 R 362242 CDS YP_906674.1 118618342 4553361 complement(3256310..3256909) 1 NC_008611.1 cytoplasmic protein; involved in transcriptional mechanism.; TetR family transcriptional regulator 3256909 4553361 MUL_2933 Mycobacterium ulcerans Agy99 TetR family transcriptional regulator YP_906674.1 3256310 R 362242 CDS YP_906675.1 118618343 4553362 3257024..3258604 1 NC_008611.1 cytoplasmic protein; function unknown, probably involved in cellular metabolism.; dehydrogenase 3258604 4553362 MUL_2934 Mycobacterium ulcerans Agy99 dehydrogenase YP_906675.1 3257024 D 362242 CDS YP_906676.1 118618344 4553363 complement(3258655..3259659) 1 NC_008611.1 cytoplasmic protein; thought to be involved in fatty acid degradation. FadB and FadA are the alpha and BetA subunits of the multifunctional enzyme complex of the fatty acid degradation cycle.; oxidoreductase FadB5 3259659 fadB5 4553363 fadB5 Mycobacterium ulcerans Agy99 oxidoreductase FadB5 YP_906676.1 3258655 R 362242 CDS YP_906677.1 118618345 4553364 complement(3259702..3260130) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3260130 4553364 MUL_2936 Mycobacterium ulcerans Agy99 hypothetical protein YP_906677.1 3259702 R 362242 CDS YP_906678.1 118618346 4553365 complement(3260127..3260453) 1 NC_008611.1 cytoplasmic protein; involved in transcriptional regulation.; ArsR-type repressor 3260453 4553365 MUL_2937 Mycobacterium ulcerans Agy99 ArsR-type repressor YP_906678.1 3260127 R 362242 CDS YP_906679.1 118618347 4553416 complement(3260512..3261231) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3261231 4553416 MUL_2938 Mycobacterium ulcerans Agy99 hypothetical protein YP_906679.1 3260512 R 362242 CDS YP_906680.1 118618348 4553417 complement(3261285..3261638) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3261638 4553417 MUL_2939 Mycobacterium ulcerans Agy99 hypothetical protein YP_906680.1 3261285 R 362242 CDS YP_906681.1 118618349 4553419 complement(3262415..3262783) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); cytoplasmic protein; hypothetical protein 3262783 4553419 MUL_2941 Mycobacterium ulcerans Agy99 hypothetical protein YP_906681.1 3262415 R 362242 CDS YP_906682.1 118618350 4553420 complement(3262948..3263994) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 3263994 4553420 MUL_2942 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_906682.1 3262948 R 362242 CDS YP_906683.1 118618351 4553421 3264294..3266582 1 NC_008611.1 cytoplasmic protein; involved in glyoxylate bypass, an alternative to the tricarboxylic acid cycle [catalytic activity: isocitrate = succinate + glyoxylate]; isocitrate lyase AceAb 3266582 aceAb 4553421 aceAb Mycobacterium ulcerans Agy99 isocitrate lyase AceAb YP_906683.1 3264294 D 362242 CDS YP_906684.1 118618352 4553424 3270518..3270985 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; hypothetical protein 3270985 4553424 MUL_2948 Mycobacterium ulcerans Agy99 hypothetical protein YP_906684.1 3270518 D 362242 CDS YP_906685.1 118618353 4553425 complement(3271044..3272207) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); cytoplasmic protein; monooxygenase 3272207 4553425 MUL_2949 Mycobacterium ulcerans Agy99 monooxygenase YP_906685.1 3271044 R 362242 CDS YP_906686.1 118618354 4553427 3273357..3274640 1 NC_008611.1 membrane protein; function unknown, lipolytic enzyme probably involved in cellular metabolism; lipase LipD 3274640 lipD 4553427 lipD Mycobacterium ulcerans Agy99 lipase LipD YP_906686.1 3273357 D 362242 CDS YP_906687.1 118618355 4553428 complement(3274661..3275410) 1 NC_008611.1 Detected in the membrane fraction by proteomics (2D- LC-MS/MS); membrane protein; hypothetical protein 3275410 4553428 MUL_2952 Mycobacterium ulcerans Agy99 hypothetical protein YP_906687.1 3274661 R 362242 CDS YP_906688.1 118618356 4553430 3277732..3280677 1 NC_008611.1 membrane protein; involved in (I) tranposition of IS2606 and (II) transport of sialic acid across the membrane. responsible for the translocation of the substrate across the membrane.; fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 3280677 4553430 MUL_2955 Mycobacterium ulcerans Agy99 fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT YP_906688.1 3277732 D 362242 CDS YP_906689.1 118618357 4553431 complement(3280350..3281639) 1 NC_008611.1 cytoplasmic protein; CinA is the first gene in the competence-inducible (cin) operon, and is thought to be specifically required at some stage in the process of transformation.; competence damage-inducible protein A 3281639 cinA 4553431 cinA Mycobacterium ulcerans Agy99 competence damage-inducible protein A YP_906689.1 3280350 R 362242 CDS YP_906690.1 118618358 4553432 complement(3281744..3281986) 1 NC_008611.1 membrane protein; PE-PGRS family protein 3281986 4553432 MUL_2957 Mycobacterium ulcerans Agy99 PE-PGRS family protein YP_906690.1 3281744 R 362242 CDS YP_906691.1 118618359 4553433 3282216..3282710 1 NC_008611.1 Truncated wrt to orthologues, missing last 12aa - potential pseudogene; membrane protein; function unknown but contains predicted phosphatase domain; lipoprotein LppD 3282710 lppD 4553433 lppD Mycobacterium ulcerans Agy99 lipoprotein LppD YP_906691.1 3282216 D 362242 CDS YP_906692.1 118618360 4553434 complement(3282707..3283033) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3283033 4553434 MUL_2959 Mycobacterium ulcerans Agy99 hypothetical protein YP_906692.1 3282707 R 362242 CDS YP_906693.1 118618361 4553435 3283330..3283761 1 NC_008611.1 hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine; D-tyrosyl-tRNA(Tyr) deacylase 3283761 4553435 MUL_2960 Mycobacterium ulcerans Agy99 D-tyrosyl-tRNA(Tyr) deacylase YP_906693.1 3283330 D 362242 CDS YP_906694.1 118618362 4553436 3283803..3284711 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; function unknown but significant domain identity with O-Methyltransferases involved in polyketide biosynthesis; hypothetical protein 3284711 4553436 MUL_2961 Mycobacterium ulcerans Agy99 hypothetical protein YP_906694.1 3283803 D 362242 CDS YP_906695.1 118618363 4553437 complement(3284701..3285726) 1 NC_008611.1 cytoplasmic protein; function unknown, probably involved in cellular metabolism; dehydrogenase 3285726 4553437 MUL_2962 Mycobacterium ulcerans Agy99 dehydrogenase YP_906695.1 3284701 R 362242 CDS YP_906696.1 118618364 4553440 3288017..3289030 1 NC_008611.1 cytoplasmic protein; generates aldehyde or ketone from alcohol [catalytic activity: alcohol + NADP(+) = aldehyde or ketone + NADPH]; NADP-dependent alcohol dehydrogenase AdhC 3289030 adhC 4553440 adhC Mycobacterium ulcerans Agy99 NADP-dependent alcohol dehydrogenase AdhC YP_906696.1 3288017 D 362242 CDS YP_906697.1 118618365 4553441 3289060..3289611 1 NC_008611.1 cytoplasmic protein; function unknown but some similarity with YceI-like family proteins. in E. coli YceI is a base-induced periplasmic protein. its function has not yet been characterised.; hypothetical protein 3289611 4553441 MUL_2966 Mycobacterium ulcerans Agy99 hypothetical protein YP_906697.1 3289060 D 362242 CDS YP_906698.1 118618366 4553442 3289786..3290457 1 NC_008611.1 membrane protein; hypothetical protein 3290457 4553442 MUL_2967 Mycobacterium ulcerans Agy99 hypothetical protein YP_906698.1 3289786 D 362242 CDS YP_906699.1 118618367 4553443 complement(3290477..3291634) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3291634 4553443 MUL_2968 Mycobacterium ulcerans Agy99 hypothetical protein YP_906699.1 3290477 R 362242 CDS YP_906700.1 118618368 4553444 3292008..3293054 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 3293054 4553444 MUL_2969 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_906700.1 3292008 D 362242 CDS YP_906701.1 118618369 4553446 3293710..3294687 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS) Also detected in the cytoplasm by proteomics.; membrane protein; involved in cell wall mycoloylation. proteins of the antigen 85 complex are responsible for the high affinity of mycobacteria to fibronectin. possesses a mycolyltransferase activity required for the biogenesis of trehalose dimycolate (cord factor), a dominant structure necessary for maintaining cell wall integrity.; secreted antigen 85-B FbpB 3294687 fbpB 4553446 fbpB Mycobacterium ulcerans Agy99 secreted antigen 85-B FbpB YP_906701.1 3293710 D 362242 CDS YP_906702.1 118618370 4553447 complement(3294771..3295445) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3295445 4553447 MUL_2971 Mycobacterium ulcerans Agy99 hypothetical protein YP_906702.1 3294771 R 362242 CDS YP_906703.1 118618371 4553448 3295547..3296491 1 NC_008611.1 cytoplasmic protein; function unknown, probably involved in cellular metabolism.; oxidoreductase 3296491 4553448 MUL_2972 Mycobacterium ulcerans Agy99 oxidoreductase YP_906703.1 3295547 D 362242 CDS YP_906704.1 118618372 4553449 3296562..3297416 1 NC_008611.1 cytoplasmic protein; function unknown, probably involved in cellular metabolism.; oxidoreductase 3297416 4553449 MUL_2973 Mycobacterium ulcerans Agy99 oxidoreductase YP_906704.1 3296562 D 362242 CDS YP_906705.1 118618373 4553450 3297433..3298041 1 NC_008611.1 catalyzes the interconversion of chorismate to prephenate; chorismate mutase 3298041 4553450 MUL_2974 Mycobacterium ulcerans Agy99 chorismate mutase YP_906705.1 3297433 D 362242 CDS YP_906706.1 118618374 4553569 3298133..3298573 1 NC_008611.1 secreted protein; thought to promote the resuscitation and growth of dormant, nongrowing cell. could also stimulate the growth of several other high G+C Gram+ organisms, E.G. mycobacterium avium, mycobacterium bovis (BCG), mycobacterium kansasii, mycobacterium smegmatis.; resuscitation-promoting factor-like protein 3298573 4553569 MUL_2975 Mycobacterium ulcerans Agy99 resuscitation-promoting factor-like protein YP_906706.1 3298133 D 362242 CDS YP_906707.1 118618375 4553570 3298629..3299087 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3299087 4553570 MUL_2976 Mycobacterium ulcerans Agy99 hypothetical protein YP_906707.1 3298629 D 362242 CDS YP_906708.1 118618376 4553571 3299102..3299935 1 NC_008611.1 cytoplasmic protein; function unknown, probably involved in cellular metabolism; short chain dehydrogenase 3299935 4553571 MUL_2977 Mycobacterium ulcerans Agy99 short chain dehydrogenase YP_906708.1 3299102 D 362242 CDS YP_906709.1 118618377 4553572 3299977..3300399 1 NC_008611.1 membrane protein; lipoprotein LppE 3300399 lppE 4553572 lppE Mycobacterium ulcerans Agy99 lipoprotein LppE YP_906709.1 3299977 D 362242 CDS YP_906710.1 118618378 4553573 3300510..3301826 1 NC_008611.1 cytoplasmic protein; cytochromes P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.; cytochrome P450 140A5 Cyp140A5 3301826 cyp140A5 4553573 cyp140A5 Mycobacterium ulcerans Agy99 cytochrome P450 140A5 Cyp140A5 YP_906710.1 3300510 D 362242 CDS YP_906711.1 118618379 4553574 3301857..3302387 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3302387 4553574 MUL_2980 Mycobacterium ulcerans Agy99 hypothetical protein YP_906711.1 3301857 D 362242 CDS YP_906712.1 118618380 4553576 3303207..3304253 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 3304253 4553576 MUL_2982 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_906712.1 3303207 D 362242 CDS YP_906713.1 118618381 4553577 complement(3304324..3305658) 1 NC_008611.1 cytoplasmic protein; required for the transposition of the insertion element IS2606.; transposase for IS2606 3305658 4553577 MUL_2983 Mycobacterium ulcerans Agy99 transposase for IS2606 YP_906713.1 3304324 R 362242 CDS YP_906714.1 118618382 4553578 3306111..3307157 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 3307157 4553578 MUL_2984 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_906714.1 3306111 D 362242 CDS YP_906715.1 118618383 4553580 complement(3311428..3312582) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3312582 4553580 MUL_2988 Mycobacterium ulcerans Agy99 hypothetical protein YP_906715.1 3311428 R 362242 CDS YP_906716.1 118618384 4553583 complement(3315364..3315858) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3315858 4553583 MUL_2992 Mycobacterium ulcerans Agy99 hypothetical protein YP_906716.1 3315364 R 362242 CDS YP_906717.1 118618385 4553584 complement(3316300..3316779) 1 NC_008611.1 cytoplasmic protein; involved in iron storage (may perform analogous functions in iron detoxification and storage as that of animal ferritins); ferritin is an intracellular molecule that stores iron in a soluble, nontoxic, readily available form. the functional molecule, which is composed of 24 chains, is roughly spherical and contains a central cavity in which the polymeric ferric iron core is deposited.; bacterioferritin BfrA 3316779 bfrA 4553584 bfrA Mycobacterium ulcerans Agy99 bacterioferritin BfrA YP_906717.1 3316300 R 362242 CDS YP_906718.1 118618386 4553605 3317107..3317289 1 NC_008611.1 function unknown but like upstream ORF, contains bacterioferritin-associated ferredoxin domain; hypothetical protein 3317289 4553605 MUL_2994 Mycobacterium ulcerans Agy99 hypothetical protein YP_906718.1 3317107 D 362242 CDS YP_906719.1 118618387 4553606 complement(3317320..3318078) 1 NC_008611.1 cytoplasmic protein; oxidizes fatty acids using specific components (by similarity) [catalytic activity: (3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H(2)O]; enoyl-CoA hydratase, EchA8_6 3318078 echA8_6 4553606 echA8_6 Mycobacterium ulcerans Agy99 enoyl-CoA hydratase, EchA8_6 YP_906719.1 3317320 R 362242 CDS YP_906720.1 118618388 4553607 complement(3318088..3318531) 1 NC_008611.1 Also detected in the membrane fraction by proteomics (LC-MS/MS); cytoplasmic protein; hypothetical protein 3318531 4553607 MUL_2996 Mycobacterium ulcerans Agy99 hypothetical protein YP_906720.1 3318088 R 362242 CDS YP_906721.1 118618389 4553608 complement(3318528..3319241) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3319241 4553608 MUL_2997 Mycobacterium ulcerans Agy99 hypothetical protein YP_906721.1 3318528 R 362242 CDS YP_906722.1 118618390 4553609 complement(3319276..3320220) 1 NC_008611.1 cytoplasmic protein; hydrogen peroxide-inducible genes activator, OxyR 3320220 oxyR 4553609 oxyR Mycobacterium ulcerans Agy99 hydrogen peroxide-inducible genes activator, OxyR YP_906722.1 3319276 R 362242 CDS YP_906723.1 118618391 4553610 3320333..3320920 1 NC_008611.1 Also detected in the extracellular matrix and the membrane fraction by proteomics.; cytoplasmic protein; involved in oxidative stress response.; alkyl hydroperoxide reductase C protein AhpC 3320920 ahpC 4553610 ahpC Mycobacterium ulcerans Agy99 alkyl hydroperoxide reductase C protein AhpC YP_906723.1 3320333 D 362242 CDS YP_906724.1 118618392 4553611 3320961..3321497 1 NC_008611.1 Detected in the cytoplasmic and membrane fractions by LCMSMS and also detected in the extracellular matrix by proteomics.; cytoplasmic protein; involved in oxidative stress response.; alkyl hydroperoxide reductase D protein AhpD 3321497 ahpD 4553611 ahpD Mycobacterium ulcerans Agy99 alkyl hydroperoxide reductase D protein AhpD YP_906724.1 3320961 D 362242 CDS YP_906725.1 118618393 4553612 3321508..3322860 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; involved in trehalose biosynthesis (protective effect) converts maltose to trehalose. mycobacteria can produce trehalose from glucose 6-phosphate and UDP-glucose (the OtsA-OtsB pathway) from glycogen-like alpha(1-->4)- linked glucose polymers (the TreY-TreZ pathway) and from maltose (the TreS pathway); trehalose synthase TreS_1 3322860 treS_1 4553612 treS_1 Mycobacterium ulcerans Agy99 trehalose synthase TreS_1 YP_906725.1 3321508 D 362242 CDS YP_906726.1 118618394 4553613 3322976..3324220 1 NC_008611.1 Detected in the membrane fraction by proteomics (2D- LC-MS/MS); membrane protein; involved in respiration; catalyzes conversion of lactate into pyruvate [catalytic activity: (S)-lactate + 2 ferricytochrome C = pyruvate + 2 ferrocytochrome C]; L-lactate dehydrogenase (cytochrome) LldD2 3324220 lldD2 4553613 lldD2 Mycobacterium ulcerans Agy99 L-lactate dehydrogenase (cytochrome) LldD2 YP_906726.1 3322976 D 362242 CDS YP_906727.1 118618395 4553614 3324324..3326666 1 NC_008611.1 cytoplasmic protein; function unknown but probably plays a role in posttranslational protein modification, turnover and chaperone functions.; Lon, ATP-dependent Lon protease 3326666 lon 4553614 lon Mycobacterium ulcerans Agy99 Lon, ATP-dependent Lon protease YP_906727.1 3324324 D 362242 CDS YP_906728.1 118618396 4553615 3326771..3327160 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS. Also detected in the membrane fraction by proteomics (2D-LC-MS/MS); cytoplasmic protein; hypothetical protein 3327160 4553615 MUL_3004 Mycobacterium ulcerans Agy99 hypothetical protein YP_906728.1 3326771 D 362242 CDS YP_906729.1 118618397 4553616 3327163..3327495 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3327495 4553616 MUL_3005 Mycobacterium ulcerans Agy99 hypothetical protein YP_906729.1 3327163 D 362242 CDS YP_906730.1 118618398 4553617 3327619..3328065 1 NC_008611.1 membrane protein; hypothetical protein 3328065 4553617 MUL_3006 Mycobacterium ulcerans Agy99 hypothetical protein YP_906730.1 3327619 D 362242 CDS YP_906731.1 118618399 4553618 complement(3328167..3330266) 1 NC_008611.1 cytoplasmic protein; function unknown but contains nucleoside- diphosphate-sugar epimerase domain identity - a domain associated with cell envelope biogenesis, carbohydrate transport and metabolism.; hypothetical protein 3330266 4553618 MUL_3007 Mycobacterium ulcerans Agy99 hypothetical protein YP_906731.1 3328167 R 362242 CDS YP_906732.1 118618400 4553619 complement(3330388..3331872) 1 NC_008611.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; acetyl-CoA acetyltransferase 3331872 4553619 MUL_3008 Mycobacterium ulcerans Agy99 acetyl-CoA acetyltransferase YP_906732.1 3330388 R 362242 CDS YP_906733.1 118618401 4553621 complement(3334505..3334831) 1 NC_008611.1 cytoplasmic protein; function unknown but contains acetyltransferase domain identity; acetyltransferase 3334831 4553621 MUL_3010 Mycobacterium ulcerans Agy99 acetyltransferase YP_906733.1 3334505 R 362242 CDS YP_906734.1 118618402 4553622 3335158..3336015 1 NC_008611.1 cytoplasmic protein; function unknown, probably involved in cellular metabolism; short chain dehydrogenase 3336015 4553622 MUL_3011 Mycobacterium ulcerans Agy99 short chain dehydrogenase YP_906734.1 3335158 D 362242 CDS YP_906735.1 118618403 4553623 3336061..3338463 1 NC_008611.1 Detected in the membrane and secreted fractions by proteomics (2D-LC-MS/MS); membrane protein; bacterial enzyme that splits fructose-6-P and/or xylulose-5-P with the aid of inorganic phosphate into either acetyl-P and erythrose-4-p and/or acetyl-P and glyeraldehyde-3-p; putative phosphoketolase 3338463 xfp 4553623 xfp Mycobacterium ulcerans Agy99 putative phosphoketolase YP_906735.1 3336061 D 362242 CDS YP_906736.1 118618404 4553640 3338514..3339179 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3339179 4553640 MUL_3013 Mycobacterium ulcerans Agy99 hypothetical protein YP_906736.1 3338514 D 362242 CDS YP_906737.1 118618405 4553642 complement(3340262..3341290) 1 NC_008611.1 cytoplasmic protein; catalyzes the reversible oxidation of ethanol to acetaldehyde with the concomitant reduction of NAD; alcohol dehydrogenase AdhA 3341290 adhA 4553642 adhA Mycobacterium ulcerans Agy99 alcohol dehydrogenase AdhA YP_906737.1 3340262 R 362242 CDS YP_906738.1 118618406 4553643 complement(3341356..3341643) 1 NC_008611.1 membrane protein; hypothetical protein 3341643 4553643 MUL_3016 Mycobacterium ulcerans Agy99 hypothetical protein YP_906738.1 3341356 R 362242 CDS YP_906739.1 118618407 4553644 complement(3341808..3342728) 1 NC_008611.1 Two isoform were also detected by proteomics in the cytoplasm.; membrane protein; function unknown could mediate bacterial attachment to host cells.; alanine and proline rich secreted protein Apa 3342728 apa 4553644 apa Mycobacterium ulcerans Agy99 alanine and proline rich secreted protein Apa YP_906739.1 3341808 R 362242 CDS YP_906740.1 118618408 4553645 complement(3342815..3343936) 1 NC_008611.1 membrane protein; part of the binding-protein-dependent transport system ModABC for molybdenum; responsible for energy coupling to the transport system.; molybdenum-transport ATP-binding protein ABC transporter ModC 3343936 modC 4553645 modC Mycobacterium ulcerans Agy99 molybdenum-transport ATP-binding protein ABC transporter ModC YP_906740.1 3342815 R 362242 CDS YP_906741.1 118618409 4553646 complement(3344120..3344320) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3344320 4553646 MUL_5112 Mycobacterium ulcerans Agy99 hypothetical protein YP_906741.1 3344120 R 362242 CDS YP_906742.1 118618410 4553647 complement(3344317..3345774) 1 NC_008611.1 cytoplasmic protein; function unknown but shows high identity with sulfide-quinone reductase from chlorobium tepidum; hypothetical protein 3345774 4553647 MUL_3019 Mycobacterium ulcerans Agy99 hypothetical protein YP_906742.1 3344317 R 362242 CDS YP_906743.1 118618411 4553648 3345976..3346809 1 NC_008611.1 cytoplasmic protein; function unknown, but possible involved in lipid metabolism; O-methyltransferase Omt 3346809 omt 4553648 omt Mycobacterium ulcerans Agy99 O-methyltransferase Omt YP_906743.1 3345976 D 362242 CDS YP_906744.1 118618412 4553649 complement(3346821..3347615) 1 NC_008611.1 membrane protein; part of the binding-protein-dependent transport system ModABC for molybdenum; responsible for the translocation of the substrate across the membrane.; molybdenum-transport integral membrane protein ABC transporter ModB 3347615 modB 4553649 modB Mycobacterium ulcerans Agy99 molybdenum-transport integral membrane protein ABC transporter ModB YP_906744.1 3346821 R 362242 CDS YP_906745.1 118618413 4553650 complement(3347624..3348337) 1 NC_008611.1 membrane protein; involved in the active transport of molybdenum into the cell across the membrane (import) part of the binding- protein-dependent transport system ModABC.; molybdate-binding lipoprotein ModA 3348337 modA 4553650 modA Mycobacterium ulcerans Agy99 molybdate-binding lipoprotein ModA YP_906745.1 3347624 R 362242 CDS YP_906746.1 118618414 4553651 3348675..3349352 1 NC_008611.1 cytoplasmic protein; function unknown, probably involved in cellular metabolism.; short chain dehydrogenase 3349352 4553651 MUL_3023 Mycobacterium ulcerans Agy99 short chain dehydrogenase YP_906746.1 3348675 D 362242 CDS YP_906747.1 118618415 4553652 3349403..3350326 1 NC_008611.1 cytoplasmic protein; function unknown, probably involved in cellular metabolism; oxidoreductase 3350326 4553652 MUL_3024 Mycobacterium ulcerans Agy99 oxidoreductase YP_906747.1 3349403 D 362242 CDS YP_906748.1 118618416 4553653 3350490..3351875 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; transfer of electrons from NADH to the respiratory chain. the immediate electron acceptor for the enzyme is believed to be ubiquinone. does not couple the redox reaction to proton translocation.; NADH dehydrogenase Ndh 3351875 ndh 4553653 ndh Mycobacterium ulcerans Agy99 NADH dehydrogenase Ndh YP_906748.1 3350490 D 362242 CDS YP_906749.1 118618417 4553654 complement(3351946..3352590) 1 NC_008611.1 cytoplasmic protein; UreD is involved in activation of the urease enzyme via the UreD-UreF-UreG-urease complex and is required for urease nickel metallocenter assembly; urease accessory protein UreD 3352590 ureD 4553654 ureD Mycobacterium ulcerans Agy99 urease accessory protein UreD YP_906749.1 3351946 R 362242 CDS YP_906750.1 118618418 4553655 complement(3352590..3353261) 1 NC_008611.1 cytoplasmic protein; UreG is required for functional incorporation of the urease nickel metallocenter. it is not known whether UreG binds GTP or some other nucleotide.; urease accessory protein UreG 3353261 ureG 4553655 ureG Mycobacterium ulcerans Agy99 urease accessory protein UreG YP_906750.1 3352590 R 362242 CDS YP_906751.1 118618419 4553656 complement(3353272..3353892) 1 NC_008611.1 cytoplasmic protein; required for the insertion of the nickel ion at the active site of the urease protein; urease accessory protein UreF 3353892 ureF 4553656 ureF Mycobacterium ulcerans Agy99 urease accessory protein UreF YP_906751.1 3353272 R 362242 CDS YP_906752.1 118618420 4553657 complement(3353907..3355640) 1 NC_008611.1 ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alpha) and 3 ureAB (gamma/beta) subunits; urease subunit alpha 3355640 ureC 4553657 ureC Mycobacterium ulcerans Agy99 urease subunit alpha YP_906752.1 3353907 R 362242 CDS YP_906753.1 118618421 4553658 complement(3355640..3355951) 1 NC_008611.1 cytoplasmic protein; involved in the conversion of UreA to NH3 [catalytic activity: UreA + H2O = CO2 + 2 NH3]; urease beta subunit UreB 3355951 ureB 4553658 ureB Mycobacterium ulcerans Agy99 urease beta subunit UreB YP_906753.1 3355640 R 362242 CDS YP_906754.1 118618422 4553659 complement(3355948..3356250) 1 NC_008611.1 UreA, with UreB and UreC catalyzes the hydrolysis of urea into ammonia and carbon dioxide; nickel metalloenzyme; accessory proteins UreD, UreE, UreF, and UreG are necessary for assembly of the metallocenter; urease subunit gamma 3356250 ureA 4553659 ureA Mycobacterium ulcerans Agy99 urease subunit gamma YP_906754.1 3355948 R 362242 CDS YP_906755.1 118618423 4553660 complement(3356310..3356750) 1 NC_008611.1 cytoplasmic protein; function unknown but domain identity suggests possibly involved in aromatic compound catabolism; hypothetical protein 3356750 4553660 MUL_3032 Mycobacterium ulcerans Agy99 hypothetical protein YP_906755.1 3356310 R 362242 CDS YP_906756.1 118618424 4553661 3357177..3357593 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; involved in transcriptional mechanism.; transcriptional regulatory protein 3357593 4553661 MUL_3033 Mycobacterium ulcerans Agy99 transcriptional regulatory protein YP_906756.1 3357177 D 362242 CDS YP_906757.1 118618425 4553662 3357608..3358558 1 NC_008611.1 membrane protein; function unknown but significant domain identity with HtpX, Zn-dependent protease with chaperone function.; hypothetical protein 3358558 4553662 MUL_3034 Mycobacterium ulcerans Agy99 hypothetical protein YP_906757.1 3357608 D 362242 CDS YP_906758.1 118618426 4553663 3358668..3360119 1 NC_008611.1 catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate; 6-phosphogluconate dehydrogenase 3360119 gnd1 4553663 gnd1 Mycobacterium ulcerans Agy99 6-phosphogluconate dehydrogenase YP_906758.1 3358668 D 362242 CDS YP_906759.1 118618427 4553664 3360151..3361587 1 NC_008611.1 catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; inosine 5-monophosphate dehydrogenase 3361587 guaB1 4553664 guaB1 Mycobacterium ulcerans Agy99 inosine 5-monophosphate dehydrogenase YP_906759.1 3360151 D 362242 CDS YP_906760.1 118618428 4553667 3363463..3365115 1 NC_008611.1 cytoplasmic protein; valine and isoleucine biosynthesis (first step) [catalytic activity : 2-acetolactate + CO(2) = 2 pyruvate]; hypothetical protein 3365115 ilvG 4553667 ilvG Mycobacterium ulcerans Agy99 hypothetical protein YP_906760.1 3363463 D 362242 CDS YP_906761.1 118618429 4553668 3365146..3367566 1 NC_008611.1 SecA2; functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond to SecA2; which is non-essential and seems to play a role in secretion of a subset of proteins; preprotein translocase subunit SecA 3367566 secA2 4553668 secA2 Mycobacterium ulcerans Agy99 preprotein translocase subunit SecA YP_906761.1 3365146 D 362242 CDS YP_906762.1 118618430 4553669 3367687..3368316 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; thought to be involved in cardiolipin biosynthesis; generates cardiolipin from phosphatidylglycerol and CDP- diacylglycerol [catalytic activity : may be: phosphatidylglycerol + phosphatidylglycerol -> cardiolipin + glycerol, or: CDP-diacylglycerol + glycerol 3-phosphate = CMP + 3-(3-phosphatidyl)-glycerol 1-phosphate]; CDP-diacylglycerol--glycerol-3-phosphate 3- phosphatidyltransferase PgsA2 3368316 pgsA2 4553669 pgsA2 Mycobacterium ulcerans Agy99 CDP-diacylglycerol--glycerol-3-phosphate 3- phosphatidyltransferase PgsA2 YP_906762.1 3367687 D 362242 CDS YP_906763.1 118618431 4553670 3368309..3369229 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3369229 4553670 MUL_3042 Mycobacterium ulcerans Agy99 hypothetical protein YP_906763.1 3368309 D 362242 CDS YP_906764.1 118618432 4553671 3369255..3369623 1 NC_008611.1 membrane protein; hypothetical protein 3369623 4553671 MUL_3043 Mycobacterium ulcerans Agy99 hypothetical protein YP_906764.1 3369255 D 362242 CDS YP_906765.1 118618433 4553672 3369648..3370538 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; hypothetical protein 3370538 4553672 MUL_3044 Mycobacterium ulcerans Agy99 hypothetical protein YP_906765.1 3369648 D 362242 CDS YP_906766.1 118618434 4553673 3370573..3370977 1 NC_008611.1 part of multienzyme complex composed of H, L, P, and T proteins which catalyzes oxidation of glycine to yield carbon dioxide, ammonia, 5,10-CH2-H4folate and a reduced pyridine nucleotide; protein H is involved in transfer of methylamine group from the P to T protein; covalently bound to a lipoyl cofactor; glycine cleavage system protein H 3370977 gcvH 4553673 gcvH Mycobacterium ulcerans Agy99 glycine cleavage system protein H YP_906766.1 3370573 D 362242 CDS YP_906767.1 118618435 4553674 3371235..3371723 1 NC_008611.1 Detected in the cytoplamic fraction by LC-MS/MS; cytoplasmic protein; function unknown but contains an FHA domain. these domains are involved in nuclear signalling domain and may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine.; hypothetical protein 3371723 4553674 MUL_3046 Mycobacterium ulcerans Agy99 hypothetical protein YP_906767.1 3371235 D 362242 CDS YP_906768.1 118618436 4553675 3371720..3372475 1 NC_008611.1 cytoplasmic protein; function unknown but high N-terminal domain identity with the MerR helix-turn-helix transcription regulator.; putative regulatory protein 3372475 4553675 MUL_3047 Mycobacterium ulcerans Agy99 putative regulatory protein YP_906768.1 3371720 D 362242 CDS YP_906769.1 118618437 4553676 3372616..3373110 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3373110 4553676 MUL_3048 Mycobacterium ulcerans Agy99 hypothetical protein YP_906769.1 3372616 D 362242 CDS YP_906770.1 118618438 4553677 3373388..3374020 1 NC_008611.1 cytoplasmic protein; function unknown but contains MerR helix-turn-helix transcription regulatory domain; regulatory protein 3374020 4553677 MUL_3049 Mycobacterium ulcerans Agy99 regulatory protein YP_906770.1 3373388 D 362242 CDS YP_906771.1 118618439 4553678 3374383..3377220 1 NC_008611.1 acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine; glycine dehydrogenase 3377220 gcvB 4553678 gcvB Mycobacterium ulcerans Agy99 glycine dehydrogenase YP_906771.1 3374383 D 362242 CDS YP_906772.1 118618440 4553680 complement(3378726..3379598) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; may act on a wide range of 1-haloalkanes, haloalcohols, haloalkenes and some haloaromatic compounds [catalytic activity: 1-haloalkane + H(2)O, a primary alcohol + halide]; haloalkane dehalogenase 3379598 4553680 MUL_3052 Mycobacterium ulcerans Agy99 haloalkane dehalogenase YP_906772.1 3378726 R 362242 CDS YP_906773.1 118618441 4553681 3379582..3380514 1 NC_008611.1 cytoplasmic protein; hydrolase 3380514 4553681 MUL_3053 Mycobacterium ulcerans Agy99 hydrolase YP_906773.1 3379582 D 362242 CDS YP_906774.1 118618442 4553682 complement(3380544..3382751) 1 NC_008611.1 Detected in the membrane fraction by proteomics (2D- LC-MS/MS); membrane protein; function unknown but weak C-term identity with vWA domain (von willebrand factor type a domain) this domain is found in extracellular proteins, like integrins, and mediates adhesion.; hypothetical protein 3382751 4553682 MUL_3054 Mycobacterium ulcerans Agy99 hypothetical protein YP_906774.1 3380544 R 362242 CDS YP_906775.1 118618443 4553683 complement(3382802..3384997) 1 NC_008611.1 catalyzes the formation of malate from glyoxylate and acetyl-CoA; malate synthase G 3384997 glcB 4553683 glcB Mycobacterium ulcerans Agy99 malate synthase G YP_906775.1 3382802 R 362242 CDS YP_906776.1 118618444 4553684 complement(3385216..3386814) 1 NC_008611.1 PE_PGRS34; membrane protein; PE-PGRS family protein 3386814 4553684 MUL_3056 Mycobacterium ulcerans Agy99 PE-PGRS family protein YP_906776.1 3385216 R 362242 CDS YP_906777.1 118618445 4553687 3389118..3391037 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; thought to be involved in active transport of drugs across the membrane (export): multidrugs resistance by an export mechanism. responsible for energy coupling to the transport system and for the translocation of the substrate across the membrane.; drug-transport transmembrane ATP-binding protein ABC transporter 3391037 4553687 MUL_3059 Mycobacterium ulcerans Agy99 drug-transport transmembrane ATP-binding protein ABC transporter YP_906777.1 3389118 D 362242 CDS YP_906778.1 118618446 4553688 complement(3391292..3392338) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 3392338 4553688 MUL_3060 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_906778.1 3391292 R 362242 CDS YP_906779.1 118618447 4553689 3392966..3394300 1 NC_008611.1 cytoplasmic protein; required for the transposition of the insertion element IS2606; transposase for IS2606 3394300 4553689 MUL_3061 Mycobacterium ulcerans Agy99 transposase for IS2606 YP_906779.1 3392966 D 362242 CDS YP_906780.1 118618448 4553690 3394387..3396999 1 NC_008611.1 PE_PGRS9_1; membrane protein; PE-PGRS family protein 3396999 4553690 MUL_3062 Mycobacterium ulcerans Agy99 PE-PGRS family protein YP_906780.1 3394387 D 362242 CDS YP_906781.1 118618449 4553691 complement(3397045..3399021) 1 NC_008611.1 translation fusion of two CDS caused by frameshift at 3' end of hypothetical protein MON6433 (3398526); membrane protein; function unknown, probably involved in cellular metabolism; flavoprotein 3399021 4553691 MUL_3063 Mycobacterium ulcerans Agy99 flavoprotein YP_906781.1 3397045 R 362242 CDS YP_906782.1 118618450 4553693 3399900..3400946 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 3400946 4553693 MUL_3065 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_906782.1 3399900 D 362242 CDS YP_906783.1 118618451 4553694 complement(3401367..3402329) 1 NC_008611.1 membrane protein; involved in lipid desaturation; membrane-bound C-5 sterol desaturase Erg3 3402329 erg3 4553694 erg3 Mycobacterium ulcerans Agy99 membrane-bound C-5 sterol desaturase Erg3 YP_906783.1 3401367 R 362242 CDS YP_906784.1 118618452 4553695 3402593..3403123 1 NC_008611.1 cytoplasmic protein; function unknown - weak domain identity with lipase/esterase proteins; hypothetical protein 3403123 4553695 MUL_3067 Mycobacterium ulcerans Agy99 hypothetical protein YP_906784.1 3402593 D 362242 CDS YP_906785.1 118618453 4553696 3403120..3404319 1 NC_008611.1 cytoplasmic protein; function unknown, probably involved in cellular metabolism; NADH dehydrogenase 3404319 4553696 MUL_3068 Mycobacterium ulcerans Agy99 NADH dehydrogenase YP_906785.1 3403120 D 362242 CDS YP_906786.1 118618454 4553697 complement(3404321..3405049) 1 NC_008611.1 membrane protein; thought to be involved in Mg2+ transport (import) may act as an accessory protein for MgtB so mediating magnesium influx into the cytosol [catalytic activity: ATP + H(2)O + mg(2+)(out) = ADP + phosphate + mg(2+)(in)]; Mg2+ transport p-type ATPase C MgtC 3405049 mgtC 4553697 mgtC Mycobacterium ulcerans Agy99 Mg2+ transport p-type ATPase C MgtC YP_906786.1 3404321 R 362242 CDS YP_906787.1 118618455 4553698 complement(3405257..3405493) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3405493 4553698 MUL_3070 Mycobacterium ulcerans Agy99 hypothetical protein YP_906787.1 3405257 R 362242 CDS YP_906788.1 118618456 4553699 complement(3405897..3407303) 1 NC_008611.1 PPE30; membrane protein; PPE family protein 3407303 4553699 MUL_3071 Mycobacterium ulcerans Agy99 PPE family protein YP_906788.1 3405897 R 362242 CDS YP_906789.1 118618457 4553700 complement(3407390..3408670) 1 NC_008611.1 PPE32; membrane protein; PPE family protein 3408670 4553700 MUL_3072 Mycobacterium ulcerans Agy99 PPE family protein YP_906789.1 3407390 R 362242 CDS YP_906790.1 118618458 4553701 complement(3409755..3410915) 1 NC_008611.1 PPE31; membrane protein; PPE family protein 3410915 4553701 MUL_3074 Mycobacterium ulcerans Agy99 PPE family protein YP_906790.1 3409755 R 362242 CDS YP_906791.1 118618459 4553703 complement(3412998..3414350) 1 NC_008611.1 PPE31_1; membrane protein; PPE family protein 3414350 4553703 MUL_3076 Mycobacterium ulcerans Agy99 PPE family protein YP_906791.1 3412998 R 362242 CDS YP_906792.1 118618460 4553704 complement(3415250..3417082) 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS. Also detected in the membrane fraction by proteomics (LC-MS/MS); membrane protein; function unknown, but domain identity to aaa, ATPase family proteins that have been associated with chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.; hypothetical protein 3417082 4553704 MUL_3077 Mycobacterium ulcerans Agy99 hypothetical protein YP_906792.1 3415250 R 362242 CDS YP_906793.1 118618461 4553705 complement(3417079..3418290) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; hypothetical protein 3418290 4553705 MUL_3078 Mycobacterium ulcerans Agy99 hypothetical protein YP_906793.1 3417079 R 362242 CDS YP_906794.1 118618462 4553706 complement(3418287..3420026) 1 NC_008611.1 Also detected in the cytoplasmic fraction by 2D-LC- MS/MS.; membrane protein; function unknown proteolytic activity but subtilases are a family of serine proteases that can play a role in posttranslational modification.; proline rich membrane-anchored mycosin MycP5 3420026 mycP5 4553706 mycP5 Mycobacterium ulcerans Agy99 proline rich membrane-anchored mycosin MycP5 YP_906794.1 3418287 R 362242 CDS YP_906795.1 118618463 4553707 complement(3420004..3421515) 1 NC_008611.1 Detected in the membrane fraction by proteomics (2D- LC-MS/MS); membrane protein; hypothetical protein 3421515 4553707 MUL_3080 Mycobacterium ulcerans Agy99 hypothetical protein YP_906795.1 3420004 R 362242 CDS YP_906796.1 118618464 4553708 complement(3421800..3422702) 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS. Also detected in the membrane fraction by proteomics (2D-LC-MS/MS); cytoplasmic protein; hypothetical protein 3422702 4553708 MUL_3081 Mycobacterium ulcerans Agy99 hypothetical protein YP_906796.1 3421800 R 362242 CDS YP_906797.1 118618465 4553709 complement(3422791..3423075) 1 NC_008611.1 Also Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; secreted protein; EsaT-6 like protein EsxN 3423075 esxN 4553709 esxN Mycobacterium ulcerans Agy99 EsaT-6 like protein EsxN YP_906797.1 3422791 R 362242 CDS YP_906798.1 118618466 4553710 complement(3423127..3423429) 1 NC_008611.1 Detected in the secreted fraction by proteomics.; secreted protein; EsaT-6 like protein EsxM 3423429 esxM 4553710 esxM Mycobacterium ulcerans Agy99 EsaT-6 like protein EsxM YP_906798.1 3423127 R 362242 CDS YP_906799.1 118618467 4553711 complement(3423773..3424072) 1 NC_008611.1 PE19; membrane protein; PE family protein 3424072 4553711 MUL_3084 Mycobacterium ulcerans Agy99 PE family protein YP_906799.1 3423773 R 362242 CDS YP_906800.1 118618468 4553712 3424894..3425940 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 3425940 4553712 MUL_3085 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_906800.1 3424894 D 362242 CDS YP_906801.1 118618469 4553731 complement(3426028..3426348) 1 NC_008611.1 secreted protein; hypothetical protein 3426348 4553731 MUL_3086 Mycobacterium ulcerans Agy99 hypothetical protein YP_906801.1 3426028 R 362242 CDS YP_906802.1 118618470 4553732 complement(3426422..3427642) 1 NC_008611.1 PPE26; Detected in the membrane fraction by proteomics (2D- LC-MS/MS); membrane protein; PPE family protein 3427642 4553732 MUL_3087 Mycobacterium ulcerans Agy99 PPE family protein YP_906802.1 3426422 R 362242 CDS YP_906803.1 118618471 4553733 complement(3427676..3427975) 1 NC_008611.1 PE19_1; membrane protein; PE family protein 3427975 4553733 MUL_3088 Mycobacterium ulcerans Agy99 PE family protein YP_906803.1 3427676 R 362242 CDS YP_906804.1 118618472 4553734 complement(3428174..3429430) 1 NC_008611.1 PPE25; membrane protein; PPE family protein 3429430 4553734 MUL_3089 Mycobacterium ulcerans Agy99 PPE family protein YP_906804.1 3428174 R 362242 CDS YP_906805.1 118618473 4553736 complement(3429982..3430176) 1 NC_008611.1 cytoplasmic protein; ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.; ferredoxin 3430176 4553736 MUL_3090 Mycobacterium ulcerans Agy99 ferredoxin YP_906805.1 3429982 R 362242 CDS YP_906806.1 118618474 4553737 3430439..3431614 1 NC_008611.1 cytoplasmic protein; cytochromes P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.; cytochrome P450 143A4 Cyp143A4 3431614 cyp143A4 4553737 cyp143A4 Mycobacterium ulcerans Agy99 cytochrome P450 143A4 Cyp143A4 YP_906806.1 3430439 D 362242 CDS YP_906807.1 118618475 4553738 complement(3431646..3435818) 1 NC_008611.1 Detected in the membrane fraction by proteomics.; membrane protein; function unknown but has multiple FtsK/SpoIIIE protein domains. This domain contains a putative ATP binding P-loop motif and is found in the FtsK cell division protein from E. coli and the stage III sporulation protein E SpoIIIE.; FtsK/SpoIIIE family protein 3435818 4553738 MUL_3092 Mycobacterium ulcerans Agy99 FtsK/SpoIIIE family protein YP_906807.1 3431646 R 362242 CDS YP_906808.1 118618476 4553739 complement(3435815..3437338) 1 NC_008611.1 Detected in the membrane fraction by proteomics.; membrane protein; hypothetical protein 3437338 4553739 MUL_3093 Mycobacterium ulcerans Agy99 hypothetical protein YP_906808.1 3435815 R 362242 CDS YP_906809.1 118618477 4553740 3437662..3439833 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; transfers a segment of a (1,4)-alpha-D-glucan to a new 4-position in an acceptor, which may be glucose or (1,4)-alpha-D-glucan; 4-alpha-glucanotransferase MalQ 3439833 malQ 4553740 malQ Mycobacterium ulcerans Agy99 4-alpha-glucanotransferase MalQ YP_906809.1 3437662 D 362242 CDS YP_906810.1 118618478 4553742 complement(3440536..3441099) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3441099 4553742 MUL_3096 Mycobacterium ulcerans Agy99 hypothetical protein YP_906810.1 3440536 R 362242 CDS YP_906811.1 118618479 4553744 3443396..3443827 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3443827 4553744 MUL_3098 Mycobacterium ulcerans Agy99 hypothetical protein YP_906811.1 3443396 D 362242 CDS YP_906812.1 118618480 4553747 3447693..3448307 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3448307 4553747 MUL_3101 Mycobacterium ulcerans Agy99 hypothetical protein YP_906812.1 3447693 D 362242 CDS YP_906813.1 118618481 4553803 3450497..3451024 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3451024 4553803 MUL_3103 Mycobacterium ulcerans Agy99 hypothetical protein YP_906813.1 3450497 D 362242 CDS YP_906814.1 118618482 4553804 complement(3451706..3452794) 1 NC_008611.1 cytoplasmic protein; glycosyl transferase 3452794 4553804 MUL_3104 Mycobacterium ulcerans Agy99 glycosyl transferase YP_906814.1 3451706 R 362242 CDS YP_906815.1 118618483 4553805 complement(3452897..3453766) 1 NC_008611.1 membrane protein; function unknown but contains signal peptide; hypothetical protein 3453766 4553805 MUL_3105 Mycobacterium ulcerans Agy99 hypothetical protein YP_906815.1 3452897 R 362242 CDS YP_906816.1 118618484 4553806 complement(3453819..3454991) 1 NC_008611.1 cytoplasmic protein; cytochromes P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.; cytochrome P450 143A3 Cyp143A3 3454991 cyp143A3 4553806 cyp143A3 Mycobacterium ulcerans Agy99 cytochrome P450 143A3 Cyp143A3 YP_906816.1 3453819 R 362242 CDS YP_906817.1 118618485 4553807 complement(3455153..3455773) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; function unknown - contains signal peptide; hypothetical protein 3455773 4553807 MUL_3107 Mycobacterium ulcerans Agy99 hypothetical protein YP_906817.1 3455153 R 362242 CDS YP_906818.1 118618486 4553808 3456003..3456896 1 NC_008611.1 cytoplasmic protein; short-chain type dehydrogenase/reductase 3456896 4553808 MUL_3108 Mycobacterium ulcerans Agy99 short-chain type dehydrogenase/reductase YP_906818.1 3456003 D 362242 CDS YP_906819.1 118618487 4553810 3458892..3459548 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3459548 4553810 MUL_3110 Mycobacterium ulcerans Agy99 hypothetical protein YP_906819.1 3458892 D 362242 CDS YP_906820.1 118618488 4553811 3459548..3459931 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3459931 4553811 MUL_3111 Mycobacterium ulcerans Agy99 hypothetical protein YP_906820.1 3459548 D 362242 CDS YP_906821.1 118618489 4553813 3460717..3461355 1 NC_008611.1 cytoplasmic protein; involved in transcriptional mechanism.; AcrR family transcriptional regulator 3461355 4553813 MUL_3113 Mycobacterium ulcerans Agy99 AcrR family transcriptional regulator YP_906821.1 3460717 D 362242 CDS YP_906822.1 118618490 4553814 complement(3461469..3461960) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3461960 4553814 MUL_3114 Mycobacterium ulcerans Agy99 hypothetical protein YP_906822.1 3461469 R 362242 CDS YP_906823.1 118618491 4553815 3462327..3462881 1 NC_008611.1 cytoplasmic protein; could cause methylation of unknown substrate.; methyltransferase 3462881 4553815 MUL_3115 Mycobacterium ulcerans Agy99 methyltransferase YP_906823.1 3462327 D 362242 CDS YP_906824.1 118618492 4553816 complement(3463025..3463321) 1 NC_008611.1 cytoplasmic protein; thioredoxin participates in various redox reactions through the reversible oxidation of its active center dithiol, to a disulfide, & catalyzes dithiol-disulfide exchange reactions.; thioredoxin TrxB1_1 3463321 trxB1_1 4553816 trxB1_1 Mycobacterium ulcerans Agy99 thioredoxin TrxB1_1 YP_906824.1 3463025 R 362242 CDS YP_906825.1 118618493 4553817 3463457..3463726 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3463726 4553817 MUL_3117 Mycobacterium ulcerans Agy99 hypothetical protein YP_906825.1 3463457 D 362242 CDS YP_906826.1 118618494 4553818 3463760..3464185 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3464185 4553818 MUL_3118 Mycobacterium ulcerans Agy99 hypothetical protein YP_906826.1 3463760 D 362242 CDS YP_906827.1 118618495 4553819 3464241..3464603 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3464603 4553819 MUL_3119 Mycobacterium ulcerans Agy99 hypothetical protein YP_906827.1 3464241 D 362242 CDS YP_906828.1 118618496 4553821 3466651..3467892 1 NC_008611.1 hypothetical protein 3467892 4553821 MUL_3122 Mycobacterium ulcerans Agy99 hypothetical protein YP_906828.1 3466651 D 362242 CDS YP_906829.1 118618497 4553822 3467960..3469165 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; function unknown but contains aminopeptidase domain identity; hypothetical protein 3469165 4553822 MUL_3123 Mycobacterium ulcerans Agy99 hypothetical protein YP_906829.1 3467960 D 362242 CDS YP_906830.1 118618498 4553841 3469162..3470448 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; function unknown, probably involved in cellular metabolism; oxidoreductase 3470448 4553841 MUL_3124 Mycobacterium ulcerans Agy99 oxidoreductase YP_906830.1 3469162 D 362242 CDS YP_906831.1 118618499 4553842 3470542..3471921 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3471921 4553842 MUL_3125 Mycobacterium ulcerans Agy99 hypothetical protein YP_906831.1 3470542 D 362242 CDS YP_906832.1 118618500 4553843 3472767..3474053 1 NC_008611.1 membrane protein; PPE family protein 3474053 4553843 MUL_3127 Mycobacterium ulcerans Agy99 PPE family protein YP_906832.1 3472767 D 362242 CDS YP_906833.1 118618501 4553844 complement(3474405..3474959) 1 NC_008611.1 cytoplasmic protein; involved in transcriptional mechanism.; transcriptional regulatory protein 3474959 4553844 MUL_3128 Mycobacterium ulcerans Agy99 transcriptional regulatory protein YP_906833.1 3474405 R 362242 CDS YP_906834.1 118618502 4553846 3479506..3480720 1 NC_008611.1 cytoplasmic protein; cytochromes P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.; cytochrome P450 144A4 Cyp144A4 3480720 cyp144A4 4553846 cyp144A4 Mycobacterium ulcerans Agy99 cytochrome P450 144A4 Cyp144A4 YP_906834.1 3479506 D 362242 CDS YP_906835.1 118618503 4553848 complement(3481883..3482929) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 3482929 4553848 MUL_3133 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_906835.1 3481883 R 362242 CDS YP_906836.1 118618504 4553851 complement(3486073..3486750) 1 NC_008611.1 secreted protein; hypothetical protein 3486750 4553851 MUL_3138 Mycobacterium ulcerans Agy99 hypothetical protein YP_906836.1 3486073 R 362242 CDS YP_906837.1 118618505 4553852 complement(3486810..3487607) 1 NC_008611.1 Also detected in the membrane fraction by proteomics (LC-MS/MS); cytoplasmic protein; function unknown, probably involved in cellular metabolism; short-chain dehydrogenase 3487607 4553852 MUL_3139 Mycobacterium ulcerans Agy99 short-chain dehydrogenase YP_906837.1 3486810 R 362242 CDS YP_906838.1 118618506 4553854 complement(3490098..3490820) 1 NC_008611.1 function unknown, lipolytic enzyme probably involved in cellular metabolism.; esterase/lipase 3490820 4553854 MUL_3141 Mycobacterium ulcerans Agy99 esterase/lipase YP_906838.1 3490098 R 362242 CDS YP_906839.1 118618507 4553855 3490955..3491371 1 NC_008611.1 cytoplasmic protein; function unknown but domain identity suggests it may be a signal-transduction protein; hypothetical protein 3491371 4553855 MUL_3142 Mycobacterium ulcerans Agy99 hypothetical protein YP_906839.1 3490955 D 362242 CDS YP_906840.1 118618508 4553856 complement(3491430..3492620) 1 NC_008611.1 cytoplasmic protein; function unknown role in cellular metabolism; amidohydrolase 3492620 4553856 MUL_3143 Mycobacterium ulcerans Agy99 amidohydrolase YP_906840.1 3491430 R 362242 CDS YP_906841.1 118618509 4553857 complement(3492746..3493570) 1 NC_008611.1 cytoplasmic protein; domain identity suggests this CDS encodes an AraD- like, ribulose-5-phosphate 4-epimerase. this enzyme and related epimerases and aldolases are involved in carbohydrate transport and metabolism.; ribulose-5-phosphate 4-epimerase, AraD 3493570 araD 4553857 araD Mycobacterium ulcerans Agy99 ribulose-5-phosphate 4-epimerase, AraD YP_906841.1 3492746 R 362242 CDS YP_906842.1 118618510 4553858 complement(3493506..3494918) 1 NC_008611.1 cytoplasmic protein; function unknown but domain identity suggests this CDS is Acs-like, acyl-coenzyme a synthetases/AMP-(fatty) acid ligases involved in lipid metabolism.; hypothetical protein 3494918 4553858 MUL_3145 Mycobacterium ulcerans Agy99 hypothetical protein YP_906842.1 3493506 R 362242 CDS YP_906843.1 118618511 4553859 3495483..3495905 1 NC_008611.1 cytoplasmic protein; acetyltransferase 3495905 4553859 MUL_3146 Mycobacterium ulcerans Agy99 acetyltransferase YP_906843.1 3495483 D 362242 CDS YP_906844.1 118618512 4553860 3496050..3496991 1 NC_008611.1 membrane protein; function unknown but some domain identity with Zn- dependent proteases; hypothetical protein 3496991 4553860 MUL_3147 Mycobacterium ulcerans Agy99 hypothetical protein YP_906844.1 3496050 D 362242 CDS YP_906845.1 118618513 4553861 3497062..3497577 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; hypothetical protein 3497577 4553861 MUL_3148 Mycobacterium ulcerans Agy99 hypothetical protein YP_906845.1 3497062 D 362242 CDS YP_906846.1 118618514 4553862 complement(3497610..3500264) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS) Also detected in the cytoplasmic fraction by 2D-LC- MS/MS.; membrane protein; thought to be involved in active transport of undeterminated substrate (possibly lipooligosaccharide) across the membrane. responsible for energy coupling to the transport system and for the translocation of the substrate across the membrane.; transmembrane ATP-binding protein ABC transporter 3500264 4553862 MUL_3149 Mycobacterium ulcerans Agy99 transmembrane ATP-binding protein ABC transporter YP_906846.1 3497610 R 362242 CDS YP_906847.1 118618515 4553863 3500384..3501718 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3501718 4553863 MUL_3150 Mycobacterium ulcerans Agy99 hypothetical protein YP_906847.1 3500384 D 362242 CDS YP_906848.1 118618516 4553865 3503183..3504229 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 3504229 4553865 MUL_3152 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_906848.1 3503183 D 362242 CDS YP_906849.1 118618517 4553866 complement(3504298..3505632) 1 NC_008611.1 cytoplasmic protein; required for the transposition of the insertion element IS2606.; transposase for IS2606 3505632 4553866 MUL_3153 Mycobacterium ulcerans Agy99 transposase for IS2606 YP_906849.1 3504298 R 362242 CDS YP_906850.1 118618518 4553867 complement(3506887..3507744) 1 NC_008611.1 cytoplasmic protein; function unknown, probably involved in cellular metabolism.; dehydrogenase 3507744 4553867 MUL_3154 Mycobacterium ulcerans Agy99 dehydrogenase YP_906850.1 3506887 R 362242 CDS YP_906851.1 118618519 4553868 complement(3508023..3509330) 1 NC_008611.1 membrane protein; involved in transport of unknown substrate across the membrane.; hypothetical protein 3509330 4553868 MUL_3155 Mycobacterium ulcerans Agy99 hypothetical protein YP_906851.1 3508023 R 362242 CDS YP_906852.1 118618520 4553869 complement(3509487..3509828) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3509828 4553869 MUL_3156 Mycobacterium ulcerans Agy99 hypothetical protein YP_906852.1 3509487 R 362242 CDS YP_906853.1 118618521 4553870 complement(3509874..3510341) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3510341 4553870 MUL_3157 Mycobacterium ulcerans Agy99 hypothetical protein YP_906853.1 3509874 R 362242 CDS YP_906854.1 118618522 4553872 3511854..3512702 1 NC_008611.1 Detected in the cytoplamic and membrane fractions by LCMSMS; cytoplasmic protein; possibly involved in detoxification reactions following oxidative damage to lipids.; short-chain dehydrogenase 3512702 4553872 MUL_3160 Mycobacterium ulcerans Agy99 short-chain dehydrogenase YP_906854.1 3511854 D 362242 CDS YP_906855.1 118618523 4553873 3512788..3514137 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3514137 4553873 MUL_3161 Mycobacterium ulcerans Agy99 hypothetical protein YP_906855.1 3512788 D 362242 CDS YP_906856.1 118618524 4553874 3514369..3515529 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3515529 4553874 MUL_3162 Mycobacterium ulcerans Agy99 hypothetical protein YP_906856.1 3514369 D 362242 CDS YP_906857.1 118618525 4553878 3518971..3519729 1 NC_008611.1 Detected in the secreted protein fractions by 2D-LC- MS/MS.; secreted protein; hypothetical protein 3519729 4553878 MUL_3166 Mycobacterium ulcerans Agy99 hypothetical protein YP_906857.1 3518971 D 362242 CDS YP_906858.1 118618526 4553879 complement(3519745..3521040) 1 NC_008611.1 membrane protein; H(+)-stimulated, highly selective, divalent cation uptake system. responsible for the translocation of the divalent metal across the membrane.; divalent cation-transport integral membrane protein 3521040 4553879 MUL_3167 Mycobacterium ulcerans Agy99 divalent cation-transport integral membrane protein YP_906858.1 3519745 R 362242 CDS YP_906859.1 118618527 4553880 3521254..3522048 1 NC_008611.1 cytoplasmic protein; short chain dehydrogenase 3522048 4553880 MUL_3168 Mycobacterium ulcerans Agy99 short chain dehydrogenase YP_906859.1 3521254 D 362242 CDS YP_906860.1 118618528 4553881 complement(3522069..3526601) 1 NC_008611.1 PPE8; membrane protein; PPE family protein 3526601 4553881 MUL_3169 Mycobacterium ulcerans Agy99 PPE family protein YP_906860.1 3522069 R 362242 CDS YP_906861.1 118618529 4553882 3527230..3528096 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3528096 4553882 MUL_3170 Mycobacterium ulcerans Agy99 hypothetical protein YP_906861.1 3527230 D 362242 CDS YP_906862.1 118618530 4553883 3528579..3529271 1 NC_008611.1 cytoplasmic protein; involved in the synthesis of decaprenyl diphosphate, a molecule which has a central role in the biosynthesis of most features of the mycobacterial cell wall. adds seven more isoprene units to omega,E, Z- farnesyl diphosphate and releases decaprenyl diphosphate.; Z-decaprenyl diphosphate synthase 3529271 4553883 MUL_3171 Mycobacterium ulcerans Agy99 Z-decaprenyl diphosphate synthase YP_906862.1 3528579 D 362242 CDS YP_906863.1 118618531 4553884 3529484..3530422 1 NC_008611.1 membrane protein; hypothetical protein 3530422 4553884 MUL_3172 Mycobacterium ulcerans Agy99 hypothetical protein YP_906863.1 3529484 D 362242 CDS YP_906864.1 118618532 4553885 3530419..3531543 1 NC_008611.1 cytoplasmic protein; transfer of electrons from NADH to the respiratory chain. the immediate electron acceptor for the enzyme is believed to be ubiquinone. does not couple the redox reaction to proton translocation.; NADH dehydrogenase Ndh1 3531543 ndh1 4553885 ndh1 Mycobacterium ulcerans Agy99 NADH dehydrogenase Ndh1 YP_906864.1 3530419 D 362242 CDS YP_906865.1 118618533 4553886 complement(3531552..3533021) 1 NC_008611.1 Detected in the membrane fraction by proteomics (2D- LC-MS/MS); secreted protein; function unknown but contains signal peptide; hypothetical protein 3533021 4553886 MUL_3174 Mycobacterium ulcerans Agy99 hypothetical protein YP_906865.1 3531552 R 362242 CDS YP_906866.1 118618534 4553887 complement(3533237..3535600) 1 NC_008611.1 cytoplasmic protein; function unknown but may play a role in protein translation; transcriptional accessory protein Tex 3535600 tex 4553887 tex Mycobacterium ulcerans Agy99 transcriptional accessory protein Tex YP_906866.1 3533237 R 362242 CDS YP_906867.1 118618535 4553888 complement(3535670..3536392) 1 NC_008611.1 membrane protein; part of a potassium transport system.; TRK system potassium uptake protein CeoC1 3536392 ceoC1 4553888 ceoC1 Mycobacterium ulcerans Agy99 TRK system potassium uptake protein CeoC1 YP_906867.1 3535670 R 362242 CDS YP_906868.1 118618536 4553889 3536639..3538135 1 NC_008611.1 the Vibrio parahaemolyticus gene VP2867 was found to be a potassium/proton antiporter; can rapidly extrude potassium against a potassium gradient at alkaline pH when cloned and expressed in Escherichia coli; potassium/proton antiporter 3538135 4553889 MUL_3177 Mycobacterium ulcerans Agy99 potassium/proton antiporter YP_906868.1 3536639 D 362242 CDS YP_906869.1 118618537 4553890 complement(3538145..3539500) 1 NC_008611.1 membrane protein; hypothetical protein 3539500 4553890 MUL_3178 Mycobacterium ulcerans Agy99 hypothetical protein YP_906869.1 3538145 R 362242 CDS YP_906870.1 118618538 4553891 complement(3539683..3540729) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 3540729 4553891 MUL_3179 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_906870.1 3539683 R 362242 CDS YP_906871.1 118618539 4553892 complement(3541009..3542772) 1 NC_008611.1 Detected in the membrane fraction by proteomics.; membrane protein; involved in signal transduction (via phosphorylation) thought to be involved in membrane transport [catalytic activity: ATP + a protein = ADP + a phosphoprotein]; transmembrane serine/threonine-protein kinase E PknE 3542772 pknE 4553892 pknE Mycobacterium ulcerans Agy99 transmembrane serine/threonine-protein kinase E PknE YP_906871.1 3541009 R 362242 CDS YP_906872.1 118618540 4554108 complement(3543001..3543738) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3543738 4554108 MUL_3181 Mycobacterium ulcerans Agy99 hypothetical protein YP_906872.1 3543001 R 362242 CDS YP_906873.1 118618541 4554109 complement(3543831..3545090) 1 NC_008611.1 membrane protein; thought to be involved in transport amino acids across the membrane.; amino acid transporter PotE 3545090 potE 4554109 potE Mycobacterium ulcerans Agy99 amino acid transporter PotE YP_906873.1 3543831 R 362242 CDS YP_906874.1 118618542 4554111 3547996..3548367 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3548367 4554111 MUL_3184 Mycobacterium ulcerans Agy99 hypothetical protein YP_906874.1 3547996 D 362242 CDS YP_906875.1 118618543 4554113 complement(3551848..3553269) 1 NC_008611.1 membrane protein; function unknown. seems to influence both cell surface interactions among mycobacteria and the interactions of bacteria with macrophages.; PE-PGRS family protein 3553269 4554113 MUL_3186 Mycobacterium ulcerans Agy99 PE-PGRS family protein YP_906875.1 3551848 R 362242 CDS YP_906876.1 118618544 4554114 complement(3553400..3554821) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; involved in active transport of unknown sugars across the membrane. responsible for the translocation of the substrate across the membrane.; sugar transporter 3554821 4554114 MUL_3187 Mycobacterium ulcerans Agy99 sugar transporter YP_906876.1 3553400 R 362242 CDS YP_906877.1 118618545 4554115 3555174..3556034 1 NC_008611.1 hypothetical protein 3556034 4554115 MUL_3188 Mycobacterium ulcerans Agy99 hypothetical protein YP_906877.1 3555174 D 362242 CDS YP_906878.1 118618546 4554116 3556336..3557523 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); secreted protein; function unknown but contains signal peptide and domain identity with periplasmic component of the tol biopolymer transport system.; hypothetical protein 3557523 4554116 MUL_3189 Mycobacterium ulcerans Agy99 hypothetical protein YP_906878.1 3556336 D 362242 CDS YP_906879.1 118618547 4554117 complement(3557527..3559083) 1 NC_008611.1 NADP-dependent semialdehyde dehydrogenase; part of alternative pathway from alpha-ketoglutarate to succinate; succinic semialdehyde dehydrogenase 3559083 gabD2 4554117 gabD2 Mycobacterium ulcerans Agy99 succinic semialdehyde dehydrogenase YP_906879.1 3557527 R 362242 CDS YP_906880.1 118618548 4554118 complement(3559252..3560238) 1 NC_008611.1 cytoplasmic protein; function unknown but domain identity with penicillin V acylase and related amidases; hydrolase/amidase 3560238 4554118 MUL_3191 Mycobacterium ulcerans Agy99 hydrolase/amidase YP_906880.1 3559252 R 362242 CDS YP_906881.1 118618549 4554119 3560491..3561168 1 NC_008611.1 secreted protein; function unknown but contains signal peptide; hypothetical protein 3561168 4554119 MUL_3192 Mycobacterium ulcerans Agy99 hypothetical protein YP_906881.1 3560491 D 362242 CDS YP_906882.1 118618550 4554121 complement(3564025..3564333) 1 NC_008611.1 membrane protein; hypothetical protein 3564333 4554121 MUL_3194 Mycobacterium ulcerans Agy99 hypothetical protein YP_906882.1 3564025 R 362242 CDS YP_906883.1 118618551 4554122 3564363..3565391 1 NC_008611.1 cytoplasmic protein; function unknown, probably involved in cellular metabolism.; hydrolase 3565391 4554122 MUL_3195 Mycobacterium ulcerans Agy99 hydrolase YP_906883.1 3564363 D 362242 CDS YP_906884.1 118618552 4554123 complement(3565433..3566731) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3566731 4554123 MUL_3196 Mycobacterium ulcerans Agy99 hypothetical protein YP_906884.1 3565433 R 362242 CDS YP_906885.1 118618553 4554124 complement(3566788..3567774) 1 NC_008611.1 cytoplasmic protein; involved in biosynthesis of membrane ether-linked lipids. catalyzes the trans-addition of the three molecules of Ipp onto DMAPP to form geranylgeranyl pyrophosphate which is a precursor of the ether-linked lipids. catalyzes the consecutive condensation of; polyprenyl synthetase IdsB 3567774 idsB 4554124 idsB Mycobacterium ulcerans Agy99 polyprenyl synthetase IdsB YP_906885.1 3566788 R 362242 CDS YP_906886.1 118618554 4554125 3568205..3568714 1 NC_008611.1 cytoplasmic protein; function unknown but may be involved in inhibition of protein synthesis by cleavage of mRNA; translation initiation inhibitor 3568714 4554125 MUL_3198 Mycobacterium ulcerans Agy99 translation initiation inhibitor YP_906886.1 3568205 D 362242 CDS YP_906887.1 118618555 4554126 3568769..3569710 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; membrane protein; hypothetical protein 3569710 4554126 MUL_3199 Mycobacterium ulcerans Agy99 hypothetical protein YP_906887.1 3568769 D 362242 CDS YP_906888.1 118618556 4554127 complement(3569700..3570026) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3570026 4554127 MUL_3200 Mycobacterium ulcerans Agy99 hypothetical protein YP_906888.1 3569700 R 362242 CDS YP_906889.1 118618557 4554158 3570202..3571014 1 NC_008611.1 cytoplasmic protein; involved in transcriptional mechanism.; GntR family transcriptional regulator 3571014 4554158 MUL_3201 Mycobacterium ulcerans Agy99 GntR family transcriptional regulator YP_906889.1 3570202 D 362242 CDS YP_906890.1 118618558 4554159 3571023..3572045 1 NC_008611.1 cytoplasmic protein; oxidoreductase 3572045 4554159 MUL_3202 Mycobacterium ulcerans Agy99 oxidoreductase YP_906890.1 3571023 D 362242 CDS YP_906891.1 118618559 4554160 3572106..3572912 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3572912 4554160 MUL_3203 Mycobacterium ulcerans Agy99 hypothetical protein YP_906891.1 3572106 D 362242 CDS YP_906892.1 118618560 4554161 complement(3572873..3573919) 1 NC_008611.1 Detected in the membrane fraction by proteomics; cytoplasmic protein; function unknown role in carbohydrate transport and metabolism; aldose 1-epimerase 3573919 4554161 MUL_3204 Mycobacterium ulcerans Agy99 aldose 1-epimerase YP_906892.1 3572873 R 362242 CDS YP_906893.1 118618561 4554162 3574204..3574650 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3574650 4554162 MUL_5114 Mycobacterium ulcerans Agy99 hypothetical protein YP_906893.1 3574204 D 362242 CDS YP_906894.1 118618562 4554164 3575202..3575537 1 NC_008611.1 secreted protein; hypothetical protein 3575537 4554164 MUL_3206 Mycobacterium ulcerans Agy99 hypothetical protein YP_906894.1 3575202 D 362242 CDS YP_906895.1 118618563 4554165 3575588..3575866 1 NC_008611.1 secreted protein; hypothetical protein 3575866 4554165 MUL_3207 Mycobacterium ulcerans Agy99 hypothetical protein YP_906895.1 3575588 D 362242 CDS YP_906896.1 118618564 4554166 3576126..3576878 1 NC_008611.1 membrane protein; this CDS encodes a 3-oxo-5-alpha-steroid 4- dehydrogenase. This family consists of 3-oxo-5-alpha- steroid 4-dehydrogenases. also known as steroid 5-alpha- reductase, the reaction catalysed by this enzyme is: 3-oxo- 5-alpha-steroid + acceptor <=> 3; hypothetical protein 3576878 4554166 MUL_3208 Mycobacterium ulcerans Agy99 hypothetical protein YP_906896.1 3576126 D 362242 CDS YP_906897.1 118618565 4554168 complement(3579606..3580364) 1 NC_008611.1 membrane protein; hypothetical protein 3580364 4554168 MUL_3210 Mycobacterium ulcerans Agy99 hypothetical protein YP_906897.1 3579606 R 362242 CDS YP_906898.1 118618566 4554170 complement(3582380..3582832) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3582832 4554170 MUL_5090 Mycobacterium ulcerans Agy99 hypothetical protein YP_906898.1 3582380 R 362242 CDS YP_906899.1 118618567 4554171 3582901..3583386 1 NC_008611.1 cytoplasmic protein; function unknown, has HTH motif of a resolvase; hypothetical protein 3583386 4554171 MUL_3212 Mycobacterium ulcerans Agy99 hypothetical protein YP_906899.1 3582901 D 362242 CDS YP_906900.1 118618568 4554190 complement(3583518..3584852) 1 NC_008611.1 cytoplasmic protein; required for the transposition of the insertion element IS2606; transposase for IS2606 3584852 4554190 MUL_3213 Mycobacterium ulcerans Agy99 transposase for IS2606 YP_906900.1 3583518 R 362242 CDS YP_906901.1 118618569 4554191 complement(3585032..3585781) 1 NC_008611.1 cytoplasmic protein; TatD related DNAse. this family of proteins are related to a large superfamily of metalloenzymes. TatD, a member of this family has been shown experimentally to be a DNAse enzyme.; TatD family deoxyribonuclease 3585781 4554191 MUL_3214 Mycobacterium ulcerans Agy99 TatD family deoxyribonuclease YP_906901.1 3585032 R 362242 CDS YP_906902.1 118618570 4554192 complement(3585781..3587043) 1 NC_008611.1 cytoplasmic protein; function unknown, contains PP-loop ATPase domain; hypothetical protein 3587043 4554192 MUL_3215 Mycobacterium ulcerans Agy99 hypothetical protein YP_906902.1 3585781 R 362242 CDS YP_906903.1 118618571 4554193 complement(3587040..3587912) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3587912 4554193 MUL_3216 Mycobacterium ulcerans Agy99 hypothetical protein YP_906903.1 3587040 R 362242 CDS YP_906904.1 118618572 4554194 complement(3587912..3589537) 1 NC_008611.1 Detected in the secreted protein fraction by proteomics.; membrane protein; P-loop ATPase 3589537 4554194 MUL_3217 Mycobacterium ulcerans Agy99 P-loop ATPase YP_906904.1 3587912 R 362242 CDS YP_906905.1 118618573 4554195 complement(3589714..3590352) 1 NC_008611.1 cytoplasmic protein; zinc metalloprotease 3590352 4554195 MUL_3218 Mycobacterium ulcerans Agy99 zinc metalloprotease YP_906905.1 3589714 R 362242 CDS YP_906906.1 118618574 4554197 3593288..3594622 1 NC_008611.1 cytoplasmic protein; required for the transposition of the insertion element IS2606.; transposase for IS2606 3594622 4554197 MUL_3220 Mycobacterium ulcerans Agy99 transposase for IS2606 YP_906906.1 3593288 D 362242 CDS YP_906907.1 118618575 4554198 complement(3595029..3596363) 1 NC_008611.1 cytoplasmic protein; required for the transposition of the insertion element IS2606.; transposase for IS2606 3596363 4554198 MUL_3221 Mycobacterium ulcerans Agy99 transposase for IS2606 YP_906907.1 3595029 R 362242 CDS YP_906908.1 118618576 4554201 complement(3599809..3601143) 1 NC_008611.1 cytoplasmic protein; required for the transposition of the insertion element IS2606.; transposase for IS2606 3601143 4554201 MUL_3224 Mycobacterium ulcerans Agy99 transposase for IS2606 YP_906908.1 3599809 R 362242 CDS YP_906909.1 118618577 4554203 3601617..3602603 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 3602603 4554203 MUL_3226 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_906909.1 3601617 D 362242 CDS YP_906910.1 118618578 4554206 3603946..3605280 1 NC_008611.1 cytoplasmic protein; required for the transposition of the insertion element IS2606.; transposase for IS2606 3605280 4554206 MUL_3229 Mycobacterium ulcerans Agy99 transposase for IS2606 YP_906910.1 3603946 D 362242 CDS YP_906911.1 118618579 4554207 3605346..3606950 1 NC_008611.1 cytoplasmic protein; Integration/excision of an unknown mycbacteriophage; prophage integrase 3606950 4554207 MUL_3230 Mycobacterium ulcerans Agy99 prophage integrase YP_906911.1 3605346 D 362242 CDS YP_906912.1 118618580 4554209 complement(3607106..3608515) 1 NC_008611.1 synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains; GTP-binding protein EngA 3608515 engA 4554209 engA Mycobacterium ulcerans Agy99 GTP-binding protein EngA YP_906912.1 3607106 R 362242 CDS YP_906913.1 118618581 4554210 complement(3608512..3609240) 1 NC_008611.1 Catalyzes the formation of (d)CDP from ATP and (d)CMP; cytidylate kinase 3609240 cmk 4554210 cmk Mycobacterium ulcerans Agy99 cytidylate kinase YP_906913.1 3608512 R 362242 CDS YP_906914.1 118618582 4554211 complement(3609311..3610072) 1 NC_008611.1 cytoplasmic protein; possible role in ribosome biogenesis and protein translation; pseudouridylate synthase 3610072 4554211 MUL_3234 Mycobacterium ulcerans Agy99 pseudouridylate synthase YP_906914.1 3609311 R 362242 CDS YP_906915.1 118618583 4554212 complement(3610072..3610779) 1 NC_008611.1 cytoplasmic protein; transcriptional regulator 3610779 4554212 MUL_3235 Mycobacterium ulcerans Agy99 transcriptional regulator YP_906915.1 3610072 R 362242 CDS YP_906916.1 118618584 4554213 complement(3610779..3611606) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3611606 4554213 MUL_3236 Mycobacterium ulcerans Agy99 hypothetical protein YP_906916.1 3610779 R 362242 CDS YP_906917.1 118618585 4554214 complement(3611603..3612559) 1 NC_008611.1 cytoplasmic protein; function unknown, possible role in chromosome partioning.; Soj family ATPase 3612559 4554214 MUL_3237 Mycobacterium ulcerans Agy99 Soj family ATPase YP_906917.1 3611603 R 362242 CDS YP_906918.1 118618586 4554215 complement(3612640..3612960) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3612960 4554215 MUL_3238 Mycobacterium ulcerans Agy99 hypothetical protein YP_906918.1 3612640 R 362242 CDS YP_906919.1 118618587 4554216 3613546..3614250 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; N-term transposase for IS2404 3614250 4554216 MUL_3239 Mycobacterium ulcerans Agy99 N-term transposase for IS2404 YP_906919.1 3613546 D 362242 CDS YP_906920.1 118618588 4554217 3614275..3614592 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; C-term transposase for IS2404 3614592 4554217 MUL_3240 Mycobacterium ulcerans Agy99 C-term transposase for IS2404 YP_906920.1 3614275 D 362242 CDS YP_906921.1 118618589 4554218 complement(3614716..3616050) 1 NC_008611.1 cytoplasmic protein; required for the transposition of the insertion element IS2606.; transposase for IS2606 3616050 4554218 MUL_3241 Mycobacterium ulcerans Agy99 transposase for IS2606 YP_906921.1 3614716 R 362242 CDS YP_906922.1 118618590 4554220 complement(3618158..3618670) 1 NC_008611.1 membrane protein; hypothetical protein 3618670 4554220 MUL_3243 Mycobacterium ulcerans Agy99 hypothetical protein YP_906922.1 3618158 R 362242 CDS YP_906923.1 118618591 4554222 3622188..3623441 1 NC_008611.1 cytoplasmic protein; transcriptional regulator 3623441 4554222 MUL_3245 Mycobacterium ulcerans Agy99 transcriptional regulator YP_906923.1 3622188 D 362242 CDS YP_906924.1 118618592 4554223 complement(3623457..3624212) 1 NC_008611.1 Detected in the cytoplasmic and secreted fractions by proteomics.; secreted protein; hypothetical protein 3624212 4554223 MUL_3246 Mycobacterium ulcerans Agy99 hypothetical protein YP_906924.1 3623457 R 362242 CDS YP_906925.1 118618593 4554224 3624487..3626082 1 NC_008611.1 PE_PGRS33; membrane protein; function unknown. seems to influence both cell surface interactions among mycobacteria and the interactions of bacteria with macrophages; PE-PGRS family protein 3626082 4554224 MUL_3247 Mycobacterium ulcerans Agy99 PE-PGRS family protein YP_906925.1 3624487 D 362242 CDS YP_906926.1 118618594 4554225 complement(3626109..3626705) 1 NC_008611.1 with PdxST is involved in the biosynthesis of pyridoxal 5'-phosphate; PdxT catalyzes the hydrolysis of glutamine to glutamate and ammonia; PdxS utilizes the ammonia to synthesize pyridoxal 5'-phosphate; glutamine amidotransferase subunit PdxT 3626705 snoP 4554225 snoP Mycobacterium ulcerans Agy99 glutamine amidotransferase subunit PdxT YP_906926.1 3626109 R 362242 CDS YP_906927.1 118618595 4554226 complement(3626713..3627558) 1 NC_008611.1 cytoplasmic protein; function unknown, lipolytic enzyme involved in cellular metabolism. can hydrolyze a broad range of acyl- CoA thioesters.; acyl-CoA thioesterase II TesB2 3627558 tesB2 4554226 tesB2 Mycobacterium ulcerans Agy99 acyl-CoA thioesterase II TesB2 YP_906927.1 3626713 R 362242 CDS YP_906928.1 118618596 4554227 complement(3627568..3628521) 1 NC_008611.1 with PdxT forms pyridoxal 5'-phosphate from glutamine, either ribose 5-phosphate or ribulose 5-phosphate, and either glyceraldehyde 3-phosphate or dihydroxyacetone phosphate; pyridoxal biosynthesis lyase PdxS 3628521 snzP 4554227 snzP Mycobacterium ulcerans Agy99 pyridoxal biosynthesis lyase PdxS YP_906928.1 3627568 R 362242 CDS YP_906929.1 118618597 4554228 complement(3628608..3629675) 1 NC_008611.1 cytoplasmic protein; function unknown but contains a NUDIX domain; hypothetical protein 3629675 4554228 MUL_3251 Mycobacterium ulcerans Agy99 hypothetical protein YP_906929.1 3628608 R 362242 CDS YP_906930.1 118618598 4554229 complement(3629675..3630871) 1 NC_008611.1 membrane protein; involved in the first mannosylation step in phosphatidylinositol mannoside biosynthesis (transfer of mannose residues onto pi, leading to the synthesis of phosphatidylinositol monomannoside); alpha-mannosyltransferase PimA 3630871 pimA 4554229 pimA Mycobacterium ulcerans Agy99 alpha-mannosyltransferase PimA YP_906930.1 3629675 R 362242 CDS YP_906931.1 118618599 4554230 complement(3630799..3631749) 1 NC_008611.1 Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA; lipid A biosynthesis lauroyl acyltransferase 3631749 4554230 MUL_3253 Mycobacterium ulcerans Agy99 lipid A biosynthesis lauroyl acyltransferase YP_906931.1 3630799 R 362242 CDS YP_906932.1 118618600 4554231 complement(3631746..3632450) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; catalyzes the transfer of a free alcohol (inositol) onto CDP-diacylglycerol. the product of this putative ORF seems be essential to mycobacteria [catalytic activity: CDP-diacylglycerol + myo-inositol = CMP + phosphatidyl 1D- myo-inositol]; pi synthase PgsA1 3632450 pgsA1 4554231 pgsA1 Mycobacterium ulcerans Agy99 pi synthase PgsA1 YP_906932.1 3631746 R 362242 CDS YP_906933.1 118618601 4554232 complement(3632458..3633030) 1 NC_008611.1 cytoplasmic protein; function unknown, but location and domain identity to hydrlases suggests it could be involved in lipid metabolism.; hypothetical protein 3633030 4554232 MUL_3255 Mycobacterium ulcerans Agy99 hypothetical protein YP_906933.1 3632458 R 362242 CDS YP_906934.1 118618602 4554233 complement(3633033..3635108) 1 NC_008611.1 catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); threonyl-tRNA synthetase 3635108 thrS 4554233 thrS Mycobacterium ulcerans Agy99 threonyl-tRNA synthetase YP_906934.1 3633033 R 362242 CDS YP_906935.1 118618603 4554234 complement(3635236..3635859) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3635859 4554234 MUL_3257 Mycobacterium ulcerans Agy99 hypothetical protein YP_906935.1 3635236 R 362242 CDS YP_906936.1 118618604 4554236 3636884..3637666 1 NC_008611.1 hypothetical protein 3637666 4554236 MUL_3259 Mycobacterium ulcerans Agy99 hypothetical protein YP_906936.1 3636884 D 362242 CDS YP_906937.1 118618605 4554238 complement(3638364..3638708) 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; hypothetical protein 3638708 4554238 MUL_3261 Mycobacterium ulcerans Agy99 hypothetical protein YP_906937.1 3638364 R 362242 CDS YP_906938.1 118618606 4554239 complement(3638721..3639146) 1 NC_008611.1 membrane protein; hypothetical protein 3639146 4554239 MUL_3262 Mycobacterium ulcerans Agy99 hypothetical protein YP_906938.1 3638721 R 362242 CDS YP_906939.1 118618607 4554240 complement(3639143..3639814) 1 NC_008611.1 cytoplasmic protein; transcriptional regulator 3639814 4554240 MUL_3263 Mycobacterium ulcerans Agy99 transcriptional regulator YP_906939.1 3639143 R 362242 CDS YP_906940.1 118618608 4554241 complement(3639824..3640171) 1 NC_008611.1 cytoplasmic protein; involved in electron transfer.; ferredoxin FdxA_1 3640171 fdxA_1 4554241 fdxA_1 Mycobacterium ulcerans Agy99 ferredoxin FdxA_1 YP_906940.1 3639824 R 362242 CDS YP_906941.1 118618609 4554242 3640339..3641757 1 NC_008611.1 membrane protein; involved in excretion of nitrite produced by the dissimilatory reduction of nitrate. responsible for the translocation of the substrate across the membrane.; integral membrane nitrite extrusion protein NarK3 3641757 narK3 4554242 narK3 Mycobacterium ulcerans Agy99 integral membrane nitrite extrusion protein NarK3 YP_906941.1 3640339 D 362242 CDS YP_906942.1 118618610 4554243 3641947..3642771 1 NC_008611.1 cytoplasmic protein; methylation of unknown substrate.; methyltransferase 3642771 4554243 MUL_3266 Mycobacterium ulcerans Agy99 methyltransferase YP_906942.1 3641947 D 362242 CDS YP_906943.1 118618611 4554244 3642901..3643794 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3643794 4554244 MUL_3267 Mycobacterium ulcerans Agy99 hypothetical protein YP_906943.1 3642901 D 362242 CDS YP_906944.1 118618612 4554246 complement(3644638..3645816) 1 NC_008611.1 membrane protein; hypothetical protein 3645816 4554246 MUL_3269 Mycobacterium ulcerans Agy99 hypothetical protein YP_906944.1 3644638 R 362242 CDS YP_906945.1 118618613 4554248 complement(3646641..3648068) 1 NC_008611.1 membrane protein; hypothetical protein 3648068 4554248 MUL_3271 Mycobacterium ulcerans Agy99 hypothetical protein YP_906945.1 3646641 R 362242 CDS YP_906946.1 118618614 4554250 3649594..3651459 1 NC_008611.1 cytoplasmic protein; involved in lipid metabolism.; long-chain-fatty-acid-CoA ligase, FadD11_1 3651459 fadD11_1 4554250 fadD11_1 Mycobacterium ulcerans Agy99 long-chain-fatty-acid-CoA ligase, FadD11_1 YP_906946.1 3649594 D 362242 CDS YP_906947.1 118618615 4554270 3651521..3652645 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3652645 4554270 MUL_3275 Mycobacterium ulcerans Agy99 hypothetical protein YP_906947.1 3651521 D 362242 CDS YP_906948.1 118618616 4554271 3652745..3654055 1 NC_008611.1 cytoplasmic protein; function unknown but contains phosphoribosyltransferase domain; hypothetical protein 3654055 4554271 MUL_3276 Mycobacterium ulcerans Agy99 hypothetical protein YP_906948.1 3652745 D 362242 CDS YP_906949.1 118618617 4554272 complement(3654089..3654370) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3654370 4554272 MUL_3277 Mycobacterium ulcerans Agy99 hypothetical protein YP_906949.1 3654089 R 362242 CDS YP_906950.1 118618618 4554274 complement(3655273..3656652) 1 NC_008611.1 cytoplasmic protein; function unknown, but involved in lipid degradation.; fatty-acid-CoA ligase 3656652 4554274 MUL_3279 Mycobacterium ulcerans Agy99 fatty-acid-CoA ligase YP_906950.1 3655273 R 362242 CDS YP_906951.1 118618619 4554275 3656884..3657540 1 NC_008611.1 membrane protein; transmembrane protein DedA 3657540 dedA 4554275 dedA Mycobacterium ulcerans Agy99 transmembrane protein DedA YP_906951.1 3656884 D 362242 CDS YP_906952.1 118618620 4554277 3658333..3658773 1 NC_008611.1 cytoplasmic protein; function unknown but contains identity with a pfam01740 STAS domain. the STAS (after sulphate transporter and antisigma factor antagonist) domain is found in the C terminal region of sulphate transporters and bacterial antisigma factor antagonists. it has been Sug; hypothetical protein 3658773 4554277 MUL_3282 Mycobacterium ulcerans Agy99 hypothetical protein YP_906952.1 3658333 D 362242 CDS YP_906953.1 118618621 4554278 complement(3658793..3659740) 1 NC_008611.1 cytoplasmic protein; it catalyses the conversion of hydrogen peroxide to water and molecular oxygen and is thus involved in the protection of cells from the toxic effects of peroxides.; catalase 3659740 4554278 MUL_3283 Mycobacterium ulcerans Agy99 catalase YP_906953.1 3658793 R 362242 CDS YP_906954.1 118618622 4554279 complement(3659783..3660082) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3660082 4554279 MUL_3284 Mycobacterium ulcerans Agy99 hypothetical protein YP_906954.1 3659783 R 362242 CDS YP_906955.1 118618623 4554280 complement(3660170..3660529) 1 NC_008611.1 cytoplasmic protein; involved in transcriptional mechanism.; ArsR family transcriptional regulator 3660529 4554280 MUL_3285 Mycobacterium ulcerans Agy99 ArsR family transcriptional regulator YP_906955.1 3660170 R 362242 CDS YP_906956.1 118618624 4554281 3660631..3661101 1 NC_008611.1 cytoplasmic protein; function unknown, in M. tuberculosis H37Rv this gene induced by cadmium (see hotter et al., 2001); hypothetical protein 3661101 cadI 4554281 cadI Mycobacterium ulcerans Agy99 hypothetical protein YP_906956.1 3660631 D 362242 CDS YP_906957.1 118618625 4554282 3661181..3661558 1 NC_008611.1 cytoplasmic protein; involved in transcriptional mechanism.; ArsR family transcriptional regulator 3661558 4554282 MUL_3287 Mycobacterium ulcerans Agy99 ArsR family transcriptional regulator YP_906957.1 3661181 D 362242 CDS YP_906958.1 118618626 4554284 3663205..3664020 1 NC_008611.1 secreted protein; hypothetical protein 3664020 4554284 MUL_3289 Mycobacterium ulcerans Agy99 hypothetical protein YP_906958.1 3663205 D 362242 CDS YP_906959.1 118618627 4554286 3665315..3666361 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 3666361 4554286 MUL_3291 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_906959.1 3665315 D 362242 CDS YP_906960.1 118618628 4554287 3666718..3668553 1 NC_008611.1 membrane protein; PE-PGRS family protein 3668553 4554287 MUL_3292 Mycobacterium ulcerans Agy99 PE-PGRS family protein YP_906960.1 3666718 D 362242 CDS YP_906961.1 118618629 4554293 complement(3670672..3672339) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3672339 4554293 MUL_3298 Mycobacterium ulcerans Agy99 hypothetical protein YP_906961.1 3670672 R 362242 CDS YP_906962.1 118618630 4554294 complement(3672336..3673331) 1 NC_008611.1 membrane protein; function unknown but has domain identity with lysophospholipases; hypothetical protein 3673331 4554294 MUL_3299 Mycobacterium ulcerans Agy99 hypothetical protein YP_906962.1 3672336 R 362242 CDS YP_906963.1 118618631 4554295 complement(3673385..3673708) 1 NC_008611.1 Detected in the secreted fraction by 2D-LC-MS/MS.; secreted protein; hypothetical protein 3673708 4554295 MUL_3300 Mycobacterium ulcerans Agy99 hypothetical protein YP_906963.1 3673385 R 362242 CDS YP_906964.1 118618632 4554296 3673817..3674560 1 NC_008611.1 cytoplasmic protein; function unknown, possibly hydrolyzes peptides and/or proteins in presence of ATP.; ATP-dependent protease ATP-binding subunit ClpC2 3674560 clpC2 4554296 clpC2 Mycobacterium ulcerans Agy99 ATP-dependent protease ATP-binding subunit ClpC2 YP_906964.1 3673817 D 362242 CDS YP_906965.1 118618633 4554297 3674684..3675199 1 NC_008611.1 secreted protein; exported alanine and valine rich protein 3675199 4554297 MUL_3302 Mycobacterium ulcerans Agy99 exported alanine and valine rich protein YP_906965.1 3674684 D 362242 CDS YP_906966.1 118618634 4554317 3675246..3675704 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3675704 4554317 MUL_3303 Mycobacterium ulcerans Agy99 hypothetical protein YP_906966.1 3675246 D 362242 CDS YP_906967.1 118618635 4554318 complement(3675682..3676794) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3676794 4554318 MUL_3304 Mycobacterium ulcerans Agy99 hypothetical protein YP_906967.1 3675682 R 362242 CDS YP_906968.1 118618636 4554319 3676816..3677598 1 NC_008611.1 cytoplasmic protein; involved in riboflavin biosynthesis (at the second and third steps) converts 2,5-diamino-6-(ribosylamino)- 4(3H)-pyrimidinone 5'-phosphate into 5-amino-6- (ribosylamino)-2,4(1H,3H)-pyrimidinedione 5'-phosphate [catalytic activity 1: 2,5-diamino-6-hydroxy-4-(5- phosphoribosylamino)pyrimidine + H(2)O = 5-amino-6-(5- phosphoribosylamino)uracil + NH(3)] [catalytic activity 2: 5-amino-6-(5-phosphoribitylamino)uracil + NADP(+) = 5- amino-6-(5-phosphoribosylamino)uracil + NADPH]; hypothetical protein 3677598 ribD 4554319 ribD Mycobacterium ulcerans Agy99 hypothetical protein YP_906968.1 3676816 D 362242 CDS YP_906969.1 118618637 4554321 3679237..3680547 1 NC_008611.1 Detected in the membrane fraction by proteomics (2D- LC-MS/MS); membrane protein; transmembrane protein 3680547 4554321 MUL_3307 Mycobacterium ulcerans Agy99 transmembrane protein YP_906969.1 3679237 D 362242 CDS YP_906970.1 118618638 4554322 3680544..3680984 1 NC_008611.1 cytoplasmic protein; function unknown but contains a SelR domain. these family of reductases are involved in the reduction of methionine sulfoxides in proteins; hypothetical protein 3680984 4554322 MUL_3308 Mycobacterium ulcerans Agy99 hypothetical protein YP_906970.1 3680544 D 362242 CDS YP_906971.1 118618639 4554323 complement(3680992..3681741) 1 NC_008611.1 cytoplasmic protein; methyltransferase 3681741 4554323 MUL_3309 Mycobacterium ulcerans Agy99 methyltransferase YP_906971.1 3680992 R 362242 CDS YP_906972.1 118618640 4554324 complement(3681738..3682433) 1 NC_008611.1 cytoplasmic protein; function unknown but contains identity to pfam06778, chlorite dismutase. this family contains chlorite dismutase enzymes of bacterial and archaeal origin. this enzyme catalyses the disproportionation of chlorite into chloride and oxygen. note that many family memb; hypothetical protein 3682433 4554324 MUL_3310 Mycobacterium ulcerans Agy99 hypothetical protein YP_906972.1 3681738 R 362242 CDS YP_906973.1 118618641 4554325 complement(3682439..3683806) 1 NC_008611.1 catalyzes the formation of protoporphyrin IX from protoporphyrinogen IX; protoporphyrinogen oxidase 3683806 hemY 4554325 hemY Mycobacterium ulcerans Agy99 protoporphyrinogen oxidase YP_906973.1 3682439 R 362242 CDS YP_906974.1 118618642 4554326 complement(3683803..3684864) 1 NC_008611.1 catalyzes the formation of coproporphyrinogen from uroporphyrinogen III; uroporphyrinogen decarboxylase 3684864 hemE 4554326 hemE Mycobacterium ulcerans Agy99 uroporphyrinogen decarboxylase YP_906974.1 3683803 R 362242 CDS YP_906975.1 118618643 4554327 3684987..3685796 1 NC_008611.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 3685796 echA15 4554327 echA15 Mycobacterium ulcerans Agy99 enoyl-CoA hydratase YP_906975.1 3684987 D 362242 CDS YP_906976.1 118618644 4554328 3685935..3686516 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; hypothetical protein 3686516 4554328 MUL_3314 Mycobacterium ulcerans Agy99 hypothetical protein YP_906976.1 3685935 D 362242 CDS YP_906977.1 118618645 4554329 3686518..3687825 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3687825 4554329 MUL_3315 Mycobacterium ulcerans Agy99 hypothetical protein YP_906977.1 3686518 D 362242 CDS YP_906978.1 118618646 4554331 3689324..3690370 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 3690370 4554331 MUL_3317 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_906978.1 3689324 D 362242 CDS YP_906979.1 118618647 4554332 3690745..3692748 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; membrane protein; PE-PGRS family protein 3692748 4554332 MUL_3318 Mycobacterium ulcerans Agy99 PE-PGRS family protein YP_906979.1 3690745 D 362242 CDS YP_906980.1 118618648 4554445 complement(3692791..3694704) 1 NC_008611.1 catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate; 1-deoxy-D-xylulose-5-phosphate synthase 3694704 dxs1 4554445 dxs1 Mycobacterium ulcerans Agy99 1-deoxy-D-xylulose-5-phosphate synthase YP_906980.1 3692791 R 362242 CDS YP_906981.1 118618649 4554446 3694857..3695351 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3695351 4554446 MUL_3320 Mycobacterium ulcerans Agy99 hypothetical protein YP_906981.1 3694857 D 362242 CDS YP_906982.1 118618650 4554447 3695407..3696696 1 NC_008611.1 membrane protein; thought to be involved in active transport of arsenical compounds across the membrane (export): arsenic resistance by an export mechanism. responsible for the translocation of the substrate across the membrane.; arsenic-transport integral membrane protein ArsA 3696696 arsA 4554447 arsA Mycobacterium ulcerans Agy99 arsenic-transport integral membrane protein ArsA YP_906982.1 3695407 D 362242 CDS YP_906983.1 118618651 4554450 complement(3698848..3699513) 1 NC_008611.1 membrane protein; thought to be involved in active transport of unidentified antibiotic across the membrane (export): antibiotic resistance by an export mechanism. responsible for the translocation of the substrate across the membrane.; antibiotic-transport integral membrane leucine and valine rich protein ABC transporter 3699513 4554450 MUL_3325 Mycobacterium ulcerans Agy99 antibiotic-transport integral membrane leucine and valine rich protein ABC transporter YP_906983.1 3698848 R 362242 CDS YP_906984.1 118618652 4554452 complement(3700516..3701721) 1 NC_008611.1 cytoplasmic protein; function unknown but domain identity suggests this CDS encodes TrmA, a protein related to tRNA (uracil-5-)- methyltransferases.; SAM-dependent methyltransferase 3701721 4554452 MUL_3327 Mycobacterium ulcerans Agy99 SAM-dependent methyltransferase YP_906984.1 3700516 R 362242 CDS YP_906985.1 118618653 4554453 complement(3701718..3703715) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; function unknown but domain identity suggests a role in amino acid transport; integral membrane alanine, valine and leucine rich protein 3703715 4554453 MUL_3328 Mycobacterium ulcerans Agy99 integral membrane alanine, valine and leucine rich protein YP_906985.1 3701718 R 362242 CDS YP_906986.1 118618654 4554454 3703848..3704531 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; part of a potassium transport system.; TRK system potassium uptake protein CeoB 3704531 ceoB 4554454 ceoB Mycobacterium ulcerans Agy99 TRK system potassium uptake protein CeoB YP_906986.1 3703848 D 362242 CDS YP_906987.1 118618655 4554455 3704584..3705246 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS; cytoplasmic protein; part of a potassium transport system.; TRK system potassium uptake protein CeoC 3705246 ceoC 4554455 ceoC Mycobacterium ulcerans Agy99 TRK system potassium uptake protein CeoC YP_906987.1 3704584 D 362242 CDS YP_906988.1 118618656 4554456 complement(3705466..3706137) 1 NC_008611.1 membrane protein; integral membrane alanine and leucine rich protein 3706137 4554456 MUL_3331 Mycobacterium ulcerans Agy99 integral membrane alanine and leucine rich protein YP_906988.1 3705466 R 362242 CDS YP_906989.1 118618657 4554457 complement(3706165..3706533) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3706533 4554457 MUL_3332 Mycobacterium ulcerans Agy99 hypothetical protein YP_906989.1 3706165 R 362242 CDS YP_906990.1 118618658 4554458 3706701..3707399 1 NC_008611.1 hypothetical protein 3707399 4554458 MUL_3333 Mycobacterium ulcerans Agy99 hypothetical protein YP_906990.1 3706701 D 362242 CDS YP_906991.1 118618659 4554459 complement(3707413..3708165) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3708165 4554459 MUL_3334 Mycobacterium ulcerans Agy99 hypothetical protein YP_906991.1 3707413 R 362242 CDS YP_906992.1 118618660 4554460 complement(3708165..3708629) 1 NC_008611.1 catalyzes the formation of dUMP from dUTP; deoxyuridine 5'-triphosphate nucleotidohydrolase 3708629 dut 4554460 dut Mycobacterium ulcerans Agy99 deoxyuridine 5'-triphosphate nucleotidohydrolase YP_906992.1 3708165 R 362242 CDS YP_906993.1 118618661 4554461 3708655..3709134 1 NC_008611.1 membrane protein; hypothetical protein 3709134 4554461 MUL_3336 Mycobacterium ulcerans Agy99 hypothetical protein YP_906993.1 3708655 D 362242 CDS YP_906994.1 118618662 4553172 complement(3709139..3709441) 1 NC_008611.1 Detected in the secreted fraction by 23D-LC-MS/MS.; cytoplasmic protein; hypothetical protein 3709441 4553172 MUL_3337 Mycobacterium ulcerans Agy99 hypothetical protein YP_906994.1 3709139 R 362242 CDS YP_906995.1 118618663 4553173 3709625..3710278 1 NC_008611.1 secreted protein; hypothetical protein 3710278 4553173 MUL_3338 Mycobacterium ulcerans Agy99 hypothetical protein YP_906995.1 3709625 D 362242 CDS YP_906996.1 118618664 4553174 complement(3710284..3711153) 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; in E. coli, SuhB mutation (SuhB2) enhances the synthesis of sigma(32) and suppresses temperature- sensitive growth of the RpoH15 mutant. may affect some step(S) of protein synthesis by facilitating the function of GroE or other heat shock proteins.; extragenic suppressor protein SuhB 3711153 suhB 4553174 suhB Mycobacterium ulcerans Agy99 extragenic suppressor protein SuhB YP_906996.1 3710284 R 362242 CDS YP_906997.1 118618665 4553175 3711275..3712069 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; catalyzes the phosphorylation of glucose using polyphosphate or ATP as the phosphoryl donor. GTP, UTP and CTP can replace ATP as phosphoryl donor [catalytic activity: (phosphate)(N) + d-glucose = (phosphate)(N-1) + d-glucose 6-phosphate]; polyphosphate glucokinase PpgK 3712069 ppgK 4553175 ppgK Mycobacterium ulcerans Agy99 polyphosphate glucokinase PpgK YP_906997.1 3711275 D 362242 CDS YP_906998.1 118618666 4553176 3712248..3713753 1 NC_008611.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; RNA polymerase sigma factor 3713753 sigA 4553176 sigA Mycobacterium ulcerans Agy99 RNA polymerase sigma factor YP_906998.1 3712248 D 362242 CDS YP_906999.1 118618667 4553178 3715933..3716367 1 NC_008611.1 cytoplasmic protein; function unknown but contains pfam01042 domain, endoribonuclease L-PSP. endoribonuclease active on single- stranded mRNA. inhibits protein synthesis by cleavage of mRNA. previously thought to inhibit protein synthesis initiation. this protein may also be involved I; hypothetical protein 3716367 4553178 MUL_3344 Mycobacterium ulcerans Agy99 hypothetical protein YP_906999.1 3715933 D 362242 CDS YP_907000.1 118618668 4553179 complement(3716295..3716675) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3716675 4553179 MUL_3345 Mycobacterium ulcerans Agy99 hypothetical protein YP_907000.1 3716295 R 362242 CDS YP_907001.1 118618669 4553180 3716802..3716987 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3716987 4553180 MUL_3346 Mycobacterium ulcerans Agy99 hypothetical protein YP_907001.1 3716802 D 362242 CDS YP_907002.1 118618670 4553181 3717053..3718027 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; hypothetical protein 3718027 4553181 MUL_3347 Mycobacterium ulcerans Agy99 hypothetical protein YP_907002.1 3717053 D 362242 CDS YP_907003.1 118618671 4553182 complement(3718028..3718276) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3718276 4553182 MUL_3348 Mycobacterium ulcerans Agy99 hypothetical protein YP_907003.1 3718028 R 362242 CDS YP_907004.1 118618672 4553183 3718313..3718741 1 NC_008611.1 membrane protein; hypothetical protein 3718741 4553183 MUL_3349 Mycobacterium ulcerans Agy99 hypothetical protein YP_907004.1 3718313 D 362242 CDS YP_907005.1 118618673 4553184 3718906..3719877 1 NC_008611.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; sigma factors in this cluster are active during stationary phase; RNA polymerase sigma factor SigB 3719877 sigB 4553184 sigB Mycobacterium ulcerans Agy99 RNA polymerase sigma factor SigB YP_907005.1 3718906 D 362242 CDS YP_907006.1 118618674 4553185 3720029..3720721 1 NC_008611.1 cytoplasmic protein; transcriptional regulatory protein (repressor and activator), iron-binding repressor of siderophore biosynthesis and iron uptake. seems to regulate a variety of genes encoding a variety of proteins E.G. transporters, proteins involved in siderophore synthesis and iron storage, members of the PE/PPE family, enzymes involved in lipid metabolism, transcriptional regulatory proteins, etc. also activator of BfrA gene.; iron-dependent repressor and activator IdeR 3720721 ideR 4553185 ideR Mycobacterium ulcerans Agy99 iron-dependent repressor and activator IdeR YP_907006.1 3720029 D 362242 CDS YP_907007.1 118618675 4553188 complement(3723054..3723371) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; C-term transposase for IS2404 3723371 4553188 MUL_3354 Mycobacterium ulcerans Agy99 C-term transposase for IS2404 YP_907007.1 3723054 R 362242 CDS YP_907008.1 118618676 4553189 complement(3723396..3724100) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; N-term transposase for IS2404 3724100 4553189 MUL_3355 Mycobacterium ulcerans Agy99 N-term transposase for IS2404 YP_907008.1 3723396 R 362242 CDS YP_907009.1 118618677 4553190 complement(3724695..3725522) 1 NC_008611.1 membrane protein; function unknown but contains weak similarity to V8- like Glu-specific endopeptidases involved in amino acid transport and metabolism.; hypothetical protein 3725522 4553190 MUL_3356 Mycobacterium ulcerans Agy99 hypothetical protein YP_907009.1 3724695 R 362242 CDS YP_907010.1 118618678 4553480 3725766..3726743 1 NC_008611.1 Also detected in the extracellular matrix by proteomics.; cytoplasmic protein; hypothetical protein 3726743 4553480 MUL_3357 Mycobacterium ulcerans Agy99 hypothetical protein YP_907010.1 3725766 D 362242 CDS YP_907011.1 118618679 4553481 3726792..3727817 1 NC_008611.1 cytoplasmic protein; function unknown, probably involved in cellular metabolism.; hydrolase 3727817 4553481 MUL_3358 Mycobacterium ulcerans Agy99 hydrolase YP_907011.1 3726792 D 362242 CDS YP_907012.1 118618680 4553482 3727862..3728548 1 NC_008611.1 cytoplasmic protein; function unknown but contains identity to an epimerase involved in phenazine biosynthesis.; hypothetical protein 3728548 4553482 MUL_3359 Mycobacterium ulcerans Agy99 hypothetical protein YP_907012.1 3727862 D 362242 CDS YP_907013.1 118618681 4553483 complement(3728558..3729043) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3729043 4553483 MUL_3360 Mycobacterium ulcerans Agy99 hypothetical protein YP_907013.1 3728558 R 362242 CDS YP_907014.1 118618682 4553484 complement(3729072..3729536) 1 NC_008611.1 Also detected in the membrane fraction by proteomics (2D-LC-MS/MS); membrane protein; transcriptional regulator NrdR 3729536 nrdR 4553484 nrdR Mycobacterium ulcerans Agy99 transcriptional regulator NrdR YP_907014.1 3729072 R 362242 CDS YP_907015.1 118618683 4553485 complement(3729699..3730241) 1 NC_008611.1 membrane protein; in M. tuberculosis H37Rv thought to be regulated by LexA.; hypothetical protein 3730241 4553485 MUL_3362 Mycobacterium ulcerans Agy99 hypothetical protein YP_907015.1 3729699 R 362242 CDS YP_907016.1 118618684 4553486 3730550..3731284 1 NC_008611.1 Represses a number of genes involved in the response to DNA damage; LexA repressor 3731284 lexA 4553486 lexA Mycobacterium ulcerans Agy99 LexA repressor YP_907016.1 3730550 D 362242 CDS YP_907017.1 118618685 4553487 complement(3731325..3733628) 1 NC_008611.1 Also detected in the cytoplasmic and membrane fractions by LC-MS/MS.; membrane protein; hypothetical protein 3733628 4553487 MUL_3364 Mycobacterium ulcerans Agy99 hypothetical protein YP_907017.1 3731325 R 362242 CDS YP_907018.1 118618686 4553490 complement(3736509..3737669) 1 NC_008611.1 cytoplasmic protein; function unknown, but involved in lipid metabolism.; acyl-CoA dehydrogenase FadE20 3737669 fadE20 4553490 fadE20 Mycobacterium ulcerans Agy99 acyl-CoA dehydrogenase FadE20 YP_907018.1 3736509 R 362242 CDS YP_907019.1 118618687 4553491 complement(3737813..3739147) 1 NC_008611.1 cytoplasmic protein; possibly a GTPase, modulating activity of HflK and HflC proteins.; GTP-binding protein HflX 3739147 hflX 4553491 hflX Mycobacterium ulcerans Agy99 GTP-binding protein HflX YP_907019.1 3737813 R 362242 CDS YP_907020.1 118618688 4553492 complement(3739374..3740246) 1 NC_008611.1 involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate; diaminopimelate epimerase 3740246 dapF 4553492 dapF Mycobacterium ulcerans Agy99 diaminopimelate epimerase YP_907020.1 3739374 R 362242 CDS YP_907021.1 118618689 4553493 complement(3740251..3741195) 1 NC_008611.1 IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity; tRNA delta(2)-isopentenylpyrophosphate transferase 3741195 miaA 4553493 miaA Mycobacterium ulcerans Agy99 tRNA delta(2)-isopentenylpyrophosphate transferase YP_907021.1 3740251 R 362242 CDS YP_907022.1 118618690 4553494 complement(3741192..3741887) 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; hypothetical protein 3741887 4553494 MUL_3371 Mycobacterium ulcerans Agy99 hypothetical protein YP_907022.1 3741192 R 362242 CDS YP_907023.1 118618691 4553495 complement(3741934..3742911) 1 NC_008611.1 membrane protein; hypothetical protein 3742911 4553495 MUL_3372 Mycobacterium ulcerans Agy99 hypothetical protein YP_907023.1 3741934 R 362242 CDS YP_907024.1 118618692 4553497 3744494..3746299 1 NC_008611.1 membrane protein; involved in signal transduction (via phosphorylation) thought to be involved in arabinan metabolism, phosphorylating perhaps EmbR [catalytic activity: ATP + a protein = ADP + a phosphoprotein]; transmembrane serine/threonine-protein kinase H PknH_2 3746299 pknH_2 4553497 pknH_2 Mycobacterium ulcerans Agy99 transmembrane serine/threonine-protein kinase H PknH_2 YP_907024.1 3744494 D 362242 CDS YP_907025.1 118618693 4551962 3746537..3747889 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3747889 4551962 MUL_3376 Mycobacterium ulcerans Agy99 hypothetical protein YP_907025.1 3746537 D 362242 CDS YP_907026.1 118618694 4551963 complement(3747886..3748497) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; hypothetical protein 3748497 4551963 MUL_3377 Mycobacterium ulcerans Agy99 hypothetical protein YP_907026.1 3747886 R 362242 CDS YP_907027.1 118618695 4551964 complement(3748494..3750092) 1 NC_008611.1 catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A); (dimethylallyl)adenosine tRNA methylthiotransferase 3750092 4551964 MUL_3378 Mycobacterium ulcerans Agy99 (dimethylallyl)adenosine tRNA methylthiotransferase YP_907027.1 3748494 R 362242 CDS YP_907028.1 118618696 4551965 complement(3750167..3750688) 1 NC_008611.1 binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities; recombination regulator RecX 3750688 recX 4551965 recX Mycobacterium ulcerans Agy99 recombination regulator RecX YP_907028.1 3750167 R 362242 CDS YP_907029.1 118618697 4551966 complement(3750654..3751694) 1 NC_008611.1 catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs; recombinase A 3751694 recA 4551966 recA Mycobacterium ulcerans Agy99 recombinase A YP_907029.1 3750654 R 362242 CDS YP_907030.1 118618698 4551967 3751784..3752512 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3752512 4551967 MUL_3381 Mycobacterium ulcerans Agy99 hypothetical protein YP_907030.1 3751784 D 362242 CDS YP_907031.1 118618699 4551968 complement(3752525..3752731) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3752731 4551968 MUL_3382 Mycobacterium ulcerans Agy99 hypothetical protein YP_907031.1 3752525 R 362242 CDS YP_907032.1 118618700 4551969 complement(3752755..3753921) 1 NC_008611.1 function unknown, probably involved in cellular metabolism.; glycosyl transferase 3753921 4551969 MUL_3383 Mycobacterium ulcerans Agy99 glycosyl transferase YP_907032.1 3752755 R 362242 CDS YP_907033.1 118618701 4551970 3754017..3754457 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); cytoplasmic protein; function unknown but contains a LimA, limonene-1,2- epoxide hydrolase domain.; hypothetical protein 3754457 4551970 MUL_3384 Mycobacterium ulcerans Agy99 hypothetical protein YP_907033.1 3754017 D 362242 CDS YP_907034.1 118618702 4551971 complement(3754357..3755280) 1 NC_008611.1 membrane protein; hypothetical protein 3755280 4551971 MUL_3385 Mycobacterium ulcerans Agy99 hypothetical protein YP_907034.1 3754357 R 362242 CDS YP_907035.1 118618703 4551972 complement(3755296..3756111) 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; function unknown but domain identity to COG1842, PspA, phage shock protein a (IM30), suppresses sigma54- dependent transcription; 35 kDa alanine rich protein 3756111 4551972 MUL_3386 Mycobacterium ulcerans Agy99 35 kDa alanine rich protein YP_907035.1 3755296 R 362242 CDS YP_907036.1 118618704 4551973 complement(3756272..3756598) 1 NC_008611.1 cytoplasmic protein; possibly involved in transcriptional mechanism.; transcriptional regulatory protein 3756598 4551973 MUL_3387 Mycobacterium ulcerans Agy99 transcriptional regulatory protein YP_907036.1 3756272 R 362242 CDS YP_907037.1 118618705 4551974 complement(3756738..3757406) 1 NC_008611.1 cytoplasmic protein; involved in acidic phospholipid biosynthesis. this protein probably catalyzes the committed step to the synthesis of the acidic phospholipids [catalytic activity: CDP-diacylglycerol + glycerol-3-phosphate = CMP + 3-(3- phosphatidyl)-glycerol 1-phosphate]; PGP synthase PgsA3 3757406 pgsA3 4551974 pgsA3 Mycobacterium ulcerans Agy99 PGP synthase PgsA3 YP_907037.1 3756738 R 362242 CDS YP_907038.1 118618706 4551975 3757392..3757916 1 NC_008611.1 catalyzes the conversion of l-glutamate to a-N-acetyl-l-glutamate in arginine biosynthesis; N-acetylglutamate synthase 3757916 4551975 MUL_3389 Mycobacterium ulcerans Agy99 N-acetylglutamate synthase YP_907038.1 3757392 D 362242 CDS YP_907039.1 118618707 4551976 complement(3757928..3760582) 1 NC_008611.1 membrane protein; possibly involved in cell division processes; cell division transmembrane protein FtsK 3760582 ftsK 4551976 ftsK Mycobacterium ulcerans Agy99 cell division transmembrane protein FtsK YP_907039.1 3757928 R 362242 CDS YP_907040.1 118618708 4551977 3760717..3761031 1 NC_008611.1 Detected in the cytoplasmic and secreted fractions by 2D-LC-MS/MS.; cytoplasmic protein; hypothetical protein 3761031 4551977 MUL_3391 Mycobacterium ulcerans Agy99 hypothetical protein YP_907040.1 3760717 D 362242 CDS YP_907041.1 118618709 4551978 3761031..3761864 1 NC_008611.1 catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-(acyl-carrier-protein) reductase 3761864 fabG 4551978 fabG Mycobacterium ulcerans Agy99 3-ketoacyl-(acyl-carrier-protein) reductase YP_907041.1 3761031 D 362242 CDS YP_907042.1 118618710 4551979 3761868..3762740 1 NC_008611.1 Detected in the membrane fraction by proteomics (2D- LC-MS/MS); membrane protein; function unknown domain identity suggests this is a methylase involved in secondary metabolism (polyketides); O-methyltransferase 3762740 4551979 MUL_3393 Mycobacterium ulcerans Agy99 O-methyltransferase YP_907042.1 3761868 D 362242 CDS YP_907043.1 118618711 4553982 complement(3763052..3763369) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; C-term transposase for IS2404 3763369 4553982 MUL_3395 Mycobacterium ulcerans Agy99 C-term transposase for IS2404 YP_907043.1 3763052 R 362242 CDS YP_907044.1 118618712 4553983 complement(3763394..3764098) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; N-term transposase for IS2404 3764098 4553983 MUL_3396 Mycobacterium ulcerans Agy99 N-term transposase for IS2404 YP_907044.1 3763394 R 362242 CDS YP_907045.1 118618713 4553985 complement(3765449..3766006) 1 NC_008611.1 cytoplasmic protein; function unknown but domain identity suggests NADPH- dependent FMN reductase; hypothetical protein 3766006 4553985 MUL_3398 Mycobacterium ulcerans Agy99 hypothetical protein YP_907045.1 3765449 R 362242 CDS YP_907046.1 118618714 4553986 3766037..3766699 1 NC_008611.1 cytoplasmic protein; involved in transcriptional mechanism.; TetR family transcriptional regulator 3766699 4553986 MUL_3399 Mycobacterium ulcerans Agy99 TetR family transcriptional regulator YP_907046.1 3766037 D 362242 CDS YP_907047.1 118618715 4553987 complement(3766740..3767615) 1 NC_008611.1 cytoplasmic protein; function unknown, but similar to various oxidoreductases and enzymes involved in polyketides synthesis; short chain dehydrogenase 3767615 4553987 MUL_3400 Mycobacterium ulcerans Agy99 short chain dehydrogenase YP_907047.1 3766740 R 362242 CDS YP_907048.1 118618716 4553988 complement(3767688..3768341) 1 NC_008611.1 cytoplasmic protein; involved in transcriptional mechanism.; TetR family transcriptional regulator 3768341 4553988 MUL_3401 Mycobacterium ulcerans Agy99 TetR family transcriptional regulator YP_907048.1 3767688 R 362242 CDS YP_907049.1 118618717 4553989 3768452..3769930 1 NC_008611.1 cytoplasmic protein; cytochromes P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.; cytochrome P450 136A2 Cyp136A2 3769930 cyp136A2 4553989 cyp136A2 Mycobacterium ulcerans Agy99 cytochrome P450 136A2 Cyp136A2 YP_907049.1 3768452 D 362242 CDS YP_907050.1 118618718 4553990 complement(3769958..3770488) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3770488 4553990 MUL_3403 Mycobacterium ulcerans Agy99 hypothetical protein YP_907050.1 3769958 R 362242 CDS YP_907051.1 118618719 4553991 3770659..3770952 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3770952 4553991 MUL_5116 Mycobacterium ulcerans Agy99 hypothetical protein YP_907051.1 3770659 D 362242 CDS YP_907052.1 118618720 4553992 complement(3770994..3771956) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3771956 4553992 MUL_3404 Mycobacterium ulcerans Agy99 hypothetical protein YP_907052.1 3770994 R 362242 CDS YP_907053.1 118618721 4553994 complement(3773567..3774670) 1 NC_008611.1 cytoplasmic protein; function unknown, supposed involvement in lipid metabolism.; acetyl-CoA acetyltransferase 3774670 4553994 MUL_3406 Mycobacterium ulcerans Agy99 acetyl-CoA acetyltransferase YP_907053.1 3773567 R 362242 CDS YP_907054.1 118618722 4553995 complement(3774712..3775758) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 3775758 4553995 MUL_3407 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_907054.1 3774712 R 362242 CDS YP_907055.1 118618723 4553996 3776187..3776543 1 NC_008611.1 cytoplasmic protein; function unknown but potential nucleic-acid-binding domain; hypothetical protein 3776543 4553996 MUL_3408 Mycobacterium ulcerans Agy99 hypothetical protein YP_907055.1 3776187 D 362242 CDS YP_907056.1 118618724 4553997 complement(3776544..3777374) 1 NC_008611.1 cytoplasmic protein; methyltransferase 3777374 4553997 MUL_3409 Mycobacterium ulcerans Agy99 methyltransferase YP_907056.1 3776544 R 362242 CDS YP_907057.1 118618725 4553998 3777540..3778214 1 NC_008611.1 cytoplasmic protein; transcriptional regulator 3778214 4553998 MUL_3410 Mycobacterium ulcerans Agy99 transcriptional regulator YP_907057.1 3777540 D 362242 CDS YP_907058.1 118618726 4553999 complement(3778248..3780413) 1 NC_008611.1 Detected in the membrane fraction by proteomics; cytoplasmic protein; function unknown, but involved in lipid metabolism.; acyl-CoA dehydrogenase FadE22 3780413 fadE22 4553999 fadE22 Mycobacterium ulcerans Agy99 acyl-CoA dehydrogenase FadE22 YP_907058.1 3778248 R 362242 CDS YP_907059.1 118618727 4554090 complement(3780524..3781282) 1 NC_008611.1 Also detected in the membrane fraction by proteomics (LC-MS/MS); cytoplasmic protein; function unknown, supposed involved in cellular metabolism.; short-chain type dehydrogenase/reductase 3781282 4554090 MUL_3412 Mycobacterium ulcerans Agy99 short-chain type dehydrogenase/reductase YP_907059.1 3780524 R 362242 CDS YP_907060.1 118618728 4554091 3781391..3782932 1 NC_008611.1 catalyzes the ATP-dependent formation of a phosphodiester at the site of a single-strand break in duplex DNA; ATP-dependent DNA ligase 3782932 ligB 4554091 ligB Mycobacterium ulcerans Agy99 ATP-dependent DNA ligase YP_907060.1 3781391 D 362242 CDS YP_907061.1 118618729 4554092 complement(3782937..3783548) 1 NC_008611.1 membrane protein; hypothetical protein 3783548 4554092 MUL_3414 Mycobacterium ulcerans Agy99 hypothetical protein YP_907061.1 3782937 R 362242 CDS YP_907062.1 118618730 4554093 3783619..3784353 1 NC_008611.1 cytoplasmic protein; involved in transcriptional mechanism; transcriptional regulatory protein 3784353 4554093 MUL_3415 Mycobacterium ulcerans Agy99 transcriptional regulatory protein YP_907062.1 3783619 D 362242 CDS YP_907063.1 118618731 4554095 complement(3785196..3785915) 1 NC_008611.1 secreted protein; hypothetical protein 3785915 4554095 MUL_5099 Mycobacterium ulcerans Agy99 hypothetical protein YP_907063.1 3785196 R 362242 CDS YP_907064.1 118618732 4554097 complement(3787036..3788370) 1 NC_008611.1 cytoplasmic protein; required for the transposition of the insertion element IS2606; transposase for IS2606 3788370 4554097 MUL_3418 Mycobacterium ulcerans Agy99 transposase for IS2606 YP_907064.1 3787036 R 362242 CDS YP_907065.1 118618733 4554098 3788886..3789932 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 3789932 4554098 MUL_3419 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_907065.1 3788886 D 362242 CDS YP_907066.1 118618734 4554100 3792915..3794453 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; acts as a chaperone. involved in induction by stress conditions E.G. heat shock. possibly has an ATPase activity. in M. tuberculosis H37Rv it is regulated positively by SigH and negatively by HspR.; chaperone protein DnaK1 3794453 dnaK1 4554100 dnaK1 Mycobacterium ulcerans Agy99 chaperone protein DnaK1 YP_907066.1 3792915 D 362242 CDS YP_907067.1 118618735 4554101 3794478..3795308 1 NC_008611.1 cytoplasmic protein; short chain dehydrogenase 3795308 4554101 MUL_3423 Mycobacterium ulcerans Agy99 short chain dehydrogenase YP_907067.1 3794478 D 362242 CDS YP_907068.1 118618736 4554102 3795398..3796033 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3796033 4554102 MUL_3424 Mycobacterium ulcerans Agy99 hypothetical protein YP_907068.1 3795398 D 362242 CDS YP_907069.1 118618737 4554103 3796102..3796425 1 NC_008611.1 membrane protein; involved in transport of multidrugs (tetraphenylphosphonium, erythromycin, ethidium bromide, acriflavine, safranin O, pyronin Y, etc) across the membrane (export): multidrugs resistance by an export mechanism (conferes resistance to toxic compounds by removing them for the cells) responsible for the translocation of the substrate across the membrane.; multidrug-transport integral membrane protein Mmr 3796425 mmr 4554103 mmr Mycobacterium ulcerans Agy99 multidrug-transport integral membrane protein Mmr YP_907069.1 3796102 D 362242 CDS YP_907070.1 118618738 4554104 3796422..3797000 1 NC_008611.1 cytoplasmic protein; involved in transcriptional mechanism.; transcriptional regulatory protein 3797000 4554104 MUL_3426 Mycobacterium ulcerans Agy99 transcriptional regulatory protein YP_907070.1 3796422 D 362242 CDS YP_907071.1 118618739 4554105 3797028..3797405 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3797405 4554105 MUL_3427 Mycobacterium ulcerans Agy99 hypothetical protein YP_907071.1 3797028 D 362242 CDS YP_907072.1 118618740 4554106 3797492..3798052 1 NC_008611.1 hypothetical protein 3798052 4554106 MUL_3428 Mycobacterium ulcerans Agy99 hypothetical protein YP_907072.1 3797492 D 362242 CDS YP_907073.1 118618741 4554107 3798205..3799989 1 NC_008611.1 cytoplasmic protein; function unknown, probably involved in cellular metabolism.; hydrolase 3799989 4554107 MUL_3429 Mycobacterium ulcerans Agy99 hydrolase YP_907073.1 3798205 D 362242 CDS YP_907074.1 118618742 4554479 complement(3799986..3801533) 1 NC_008611.1 Detected in the membrane fraction by proteomics (2D- LC-MS/MS); membrane protein; involved in 4-aminobutyrate (GabA) degradation pathway [catalytic activity: succinate semialdehyde + NAD(P)(+) + H(2)O = succinate + NAD(P)H]; succinate-semialdehyde dehydrogenase [NADP+] dependent, PutA_2 3801533 putA_2 4554479 putA_2 Mycobacterium ulcerans Agy99 succinate-semialdehyde dehydrogenase [NADP+] dependent, PutA_2 YP_907074.1 3799986 R 362242 CDS YP_907075.1 118618743 4554480 complement(3801626..3802951) 1 NC_008611.1 cytoplasmic protein; function unknown, but involved in lipid degradation.; fatty-acid-CoA ligase 3802951 4554480 MUL_3431 Mycobacterium ulcerans Agy99 fatty-acid-CoA ligase YP_907075.1 3801626 R 362242 CDS YP_907076.1 118618744 4554482 complement(3804486..3805376) 1 NC_008611.1 membrane protein; function unknown but contains Cdd pfam03982, DAGAT, diacylglycerol acyltransferase domain.; hypothetical protein 3805376 4554482 MUL_3433 Mycobacterium ulcerans Agy99 hypothetical protein YP_907076.1 3804486 R 362242 CDS YP_907077.1 118618745 4554483 3805658..3806923 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3806923 4554483 MUL_3434 Mycobacterium ulcerans Agy99 hypothetical protein YP_907077.1 3805658 D 362242 CDS YP_907078.1 118618746 4554484 complement(3806959..3808932) 1 NC_008611.1 Good u/s rbs.; function unknown, probably involved in cellular metabolism.; oxidoreductase GMC-type 3808932 4554484 MUL_3435 Mycobacterium ulcerans Agy99 oxidoreductase GMC-type YP_907078.1 3806959 R 362242 CDS YP_907079.1 118618747 4554486 complement(3809945..3810991) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 3810991 4554486 MUL_3437 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_907079.1 3809945 R 362242 CDS YP_907080.1 118618748 4554487 complement(3811889..3813220) 1 NC_008611.1 cytoplasmic protein; required for the transposition of the insertion element IS2606.; transposase for IS2606 3813220 4554487 MUL_3438 Mycobacterium ulcerans Agy99 transposase for IS2606 YP_907080.1 3811889 R 362242 CDS YP_907081.1 118618749 4554489 3817755..3817907 1 NC_008611.1 cytoplasmic protein; function unknown but has domain similarity to quinoprotein amine dehydrogenases; hypothetical protein 3817907 4554489 MUL_3440 Mycobacterium ulcerans Agy99 hypothetical protein YP_907081.1 3817755 D 362242 CDS YP_907082.1 118618750 4553259 complement(3818414..3820045) 1 NC_008611.1 catalyzes the interconversion of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate; phosphoglucomutase 3820045 pgmA 4553259 pgmA Mycobacterium ulcerans Agy99 phosphoglucomutase YP_907082.1 3818414 R 362242 CDS YP_907083.1 118618751 4553260 3820491..3821555 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 3821555 4553260 MUL_3443 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_907083.1 3820491 D 362242 CDS YP_907084.1 118618752 4553262 3822332..3823438 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3823438 4553262 MUL_3446 Mycobacterium ulcerans Agy99 hypothetical protein YP_907084.1 3822332 D 362242 CDS YP_907085.1 118618753 4553263 complement(3823449..3824072) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3824072 4553263 MUL_3447 Mycobacterium ulcerans Agy99 hypothetical protein YP_907085.1 3823449 R 362242 CDS YP_907086.1 118618754 4553264 complement(3824086..3824964) 1 NC_008611.1 cytoplasmic protein; oxidoreductase 3824964 4553264 MUL_3448 Mycobacterium ulcerans Agy99 oxidoreductase YP_907086.1 3824086 R 362242 CDS YP_907087.1 118618755 4553265 complement(3825006..3825362) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3825362 4553265 MUL_3449 Mycobacterium ulcerans Agy99 hypothetical protein YP_907087.1 3825006 R 362242 CDS YP_907088.1 118618756 4553267 complement(3826718..3827653) 1 NC_008611.1 cytoplasmic protein; interconversion of acetate and oxaloacetate from citrate [catalytic activity: citrate = acetate + oxaloacetate]; citrate lyase beta subunit, CitE_2 3827653 citE_2 4553267 citE_2 Mycobacterium ulcerans Agy99 citrate lyase beta subunit, CitE_2 YP_907088.1 3826718 R 362242 CDS YP_907089.1 118618757 4553268 complement(3827744..3829021) 1 NC_008611.1 cytoplasmic protein; function unknown but domain identity suggests transcriptional regulator; hypothetical protein 3829021 4553268 MUL_3452 Mycobacterium ulcerans Agy99 hypothetical protein YP_907089.1 3827744 R 362242 CDS YP_907090.1 118618758 4553269 3829213..3831030 1 NC_008611.1 membrane protein; hypothetical protein 3831030 4553269 MUL_3453 Mycobacterium ulcerans Agy99 hypothetical protein YP_907090.1 3829213 D 362242 CDS YP_907091.1 118618759 4553272 3834290..3834739 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3834739 4553272 MUL_3456 Mycobacterium ulcerans Agy99 hypothetical protein YP_907091.1 3834290 D 362242 CDS YP_907092.1 118618760 4553273 3834732..3836543 1 NC_008611.1 cytoplasmic protein; function unknown but domain homology to arylsulfatase a ( AslA )and related enzymes.; hydrolase 3836543 4553273 MUL_3457 Mycobacterium ulcerans Agy99 hydrolase YP_907092.1 3834732 D 362242 CDS YP_907093.1 118618761 4553275 complement(3837162..3837989) 1 NC_008611.1 cytoplasmic protein; oxidoreductase 3837989 4553275 MUL_3458 Mycobacterium ulcerans Agy99 oxidoreductase YP_907093.1 3837162 R 362242 CDS YP_907094.1 118618762 4553276 complement(3837998..3838396) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; hypothetical protein 3838396 4553276 MUL_3459 Mycobacterium ulcerans Agy99 hypothetical protein YP_907094.1 3837998 R 362242 CDS YP_907095.1 118618763 4552758 3838476..3839939 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3839939 4552758 MUL_3460 Mycobacterium ulcerans Agy99 hypothetical protein YP_907095.1 3838476 D 362242 CDS YP_907096.1 118618764 4552759 3840320..3840997 1 NC_008611.1 cytoplasmic protein; function unknown, first 70 aa missing WRT to orthologues; hypothetical protein 3840997 4552759 MUL_3461 Mycobacterium ulcerans Agy99 hypothetical protein YP_907096.1 3840320 D 362242 CDS YP_907097.1 118618765 4552761 3842776..3843420 1 NC_008611.1 secreted protein; hypothetical protein 3843420 4552761 MUL_3463 Mycobacterium ulcerans Agy99 hypothetical protein YP_907097.1 3842776 D 362242 CDS YP_907098.1 118618766 4552762 3843474..3844241 1 NC_008611.1 cytoplasmic protein; putative regulatory protein 3844241 4552762 MUL_3464 Mycobacterium ulcerans Agy99 putative regulatory protein YP_907098.1 3843474 D 362242 CDS YP_907099.1 118618767 4552764 complement(3845094..3845945) 1 NC_008611.1 membrane protein; hypothetical protein 3845945 4552764 MUL_3466 Mycobacterium ulcerans Agy99 hypothetical protein YP_907099.1 3845094 R 362242 CDS YP_907100.1 118618768 4552765 3846293..3847339 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 3847339 4552765 MUL_3467 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_907100.1 3846293 D 362242 CDS YP_907101.1 118618769 4552767 3848339..3849283 1 NC_008611.1 cytoplasmic protein; catalyzes the first step in the biosynthesis of 2- methylthio-N6-(delta(2)-isopentenyl)-adenosine adjacent to the anticodon of several tRNA species [catalytic activity: isopentenyl diphosphate + tRNA = pyrophosphate + tRNA containing 6-isopentenyladenosine]; tRNA delta(2)-isopentenylpyrophosphate transferase MiaA_1 3849283 miaA_1 4552767 miaA_1 Mycobacterium ulcerans Agy99 tRNA delta(2)-isopentenylpyrophosphate transferase MiaA_1 YP_907101.1 3848339 D 362242 CDS YP_907102.1 118618770 4552768 3849370..3850350 1 NC_008611.1 functions in degradation of stringent response intracellular messenger ppGpp; in Escherichia coli this gene is co-transcribed with the toxin/antitoxin genes mazEF; activity of MazG is inhibited by MazEF in vitro; ppGpp inhibits mazEF expression; MazG thus works in limiting the toxic activity of the MazF toxin induced during starvation; MazG also interacts with the GTPase protein Era; nucleoside triphosphate pyrophosphohydrolase 3850350 4552768 MUL_3470 Mycobacterium ulcerans Agy99 nucleoside triphosphate pyrophosphohydrolase YP_907102.1 3849370 D 362242 CDS YP_907103.1 118618771 4552770 complement(3851720..3852922) 1 NC_008611.1 cytoplasmic protein; NADP-dependent oxidoreductase 3852922 4552770 MUL_3472 Mycobacterium ulcerans Agy99 NADP-dependent oxidoreductase YP_907103.1 3851720 R 362242 CDS YP_907104.1 118618772 4552772 complement(3853907..3855130) 1 NC_008611.1 cytoplasmic protein; dehydrogenase 3855130 4552772 MUL_3474 Mycobacterium ulcerans Agy99 dehydrogenase YP_907104.1 3853907 R 362242 CDS YP_907105.1 118618773 4552773 3855177..3855653 1 NC_008611.1 cytoplasmic protein; transcriptional regulatory protein 3855653 4552773 MUL_3475 Mycobacterium ulcerans Agy99 transcriptional regulatory protein YP_907105.1 3855177 D 362242 CDS YP_907106.1 118618774 4552774 3855911..3857050 1 NC_008611.1 secreted protein; hypothetical protein 3857050 4552774 MUL_3476 Mycobacterium ulcerans Agy99 hypothetical protein YP_907106.1 3855911 D 362242 CDS YP_907107.1 118618775 4552775 complement(3857064..3857552) 1 NC_008611.1 secreted protein; hypothetical protein 3857552 4552775 MUL_3477 Mycobacterium ulcerans Agy99 hypothetical protein YP_907107.1 3857064 R 362242 CDS YP_907108.1 118618776 4552250 complement(3857853..3858095) 1 NC_008611.1 secreted protein; hypothetical protein 3858095 4552250 MUL_3478 Mycobacterium ulcerans Agy99 hypothetical protein YP_907108.1 3857853 R 362242 CDS YP_907109.1 118618777 4552251 3858242..3859090 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3859090 4552251 MUL_3479 Mycobacterium ulcerans Agy99 hypothetical protein YP_907109.1 3858242 D 362242 CDS YP_907110.1 118618778 4552252 3859370..3859987 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; N-term transposase for IS2404 3859987 4552252 MUL_3480 Mycobacterium ulcerans Agy99 N-term transposase for IS2404 YP_907110.1 3859370 D 362242 CDS YP_907111.1 118618779 4552253 3860072..3860416 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; C-term transposase for IS2404 3860416 4552253 MUL_3481 Mycobacterium ulcerans Agy99 C-term transposase for IS2404 YP_907111.1 3860072 D 362242 CDS YP_907112.1 118618780 4552255 complement(3862725..3863171) 1 NC_008611.1 cytoplasmic protein; function unknown but has domain similarity to predicted flavin-nucleotide-binding proteins; hypothetical protein 3863171 4552255 MUL_3483 Mycobacterium ulcerans Agy99 hypothetical protein YP_907112.1 3862725 R 362242 CDS YP_907113.1 118618781 4552256 complement(3863241..3864203) 1 NC_008611.1 catalyzes the formation of glutamate from glutamine; glutaminase 3864203 glsA 4552256 glsA Mycobacterium ulcerans Agy99 glutaminase YP_907113.1 3863241 R 362242 CDS YP_907114.1 118618782 4552258 complement(3864892..3865938) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 3865938 4552258 MUL_3486 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_907114.1 3864892 R 362242 CDS YP_907115.1 118618783 4552259 complement(3866391..3867725) 1 NC_008611.1 cytoplasmic protein; required for the transposition of the insertion element IS2606.; transposase for IS2606 3867725 4552259 MUL_3487 Mycobacterium ulcerans Agy99 transposase for IS2606 YP_907115.1 3866391 R 362242 CDS YP_907116.1 118618784 4552263 3869647..3870588 1 NC_008611.1 cytoplasmic protein; function unknown but contains lysophospholipase domain; hypothetical protein 3870588 4552263 MUL_3490 Mycobacterium ulcerans Agy99 hypothetical protein YP_907116.1 3869647 D 362242 CDS YP_907117.1 118618785 4552264 3870998..3871432 1 NC_008611.1 cytoplasmic protein; function unknown, contains predicted nucleic acid- binding pin domain; hypothetical protein 3871432 4552264 MUL_3491 Mycobacterium ulcerans Agy99 hypothetical protein YP_907117.1 3870998 D 362242 CDS YP_907118.1 118618786 4552265 complement(3871628..3872032) 1 NC_008611.1 membrane protein; hypothetical protein 3872032 4552265 MUL_3492 Mycobacterium ulcerans Agy99 hypothetical protein YP_907118.1 3871628 R 362242 CDS YP_907119.1 118618787 4550964 complement(3872117..3872911) 1 NC_008611.1 Detected in the membrane and the cytoplamic fractions by proteomics.; secreted protein; function unknown but corresponds to antigen 84 of mycobacterium tuberculosis (Wag31) (see hermans et al., 1995) predicted to contain significant amount of coiled coil structure.; secreted antigen Wag31 3872911 wag31 4550964 wag31 Mycobacterium ulcerans Agy99 secreted antigen Wag31 YP_907119.1 3872117 R 362242 CDS YP_907120.1 118618788 4550965 complement(3873168..3873458) 1 NC_008611.1 membrane protein; hypothetical protein 3873458 4550965 MUL_3494 Mycobacterium ulcerans Agy99 hypothetical protein YP_907120.1 3873168 R 362242 CDS YP_907121.1 118618789 4550966 complement(3873636..3874307) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3874307 4550966 MUL_3495 Mycobacterium ulcerans Agy99 hypothetical protein YP_907121.1 3873636 R 362242 CDS YP_907122.1 118618790 4550967 complement(3874372..3875148) 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; hypothetical protein 3875148 4550967 MUL_3496 Mycobacterium ulcerans Agy99 hypothetical protein YP_907122.1 3874372 R 362242 CDS YP_907123.1 118618791 4550968 complement(3875154..3875942) 1 NC_008611.1 Detected in the membrane fraction by proteomics.; membrane protein; membrane protein YfiH 3875942 yfiH 4550968 yfiH Mycobacterium ulcerans Agy99 membrane protein YfiH YP_907123.1 3875154 R 362242 CDS YP_907124.1 118618792 4550969 complement(3875953..3877116) 1 NC_008611.1 GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function; cell division protein FtsZ 3877116 ftsZ 4550969 ftsZ Mycobacterium ulcerans Agy99 cell division protein FtsZ YP_907124.1 3875953 R 362242 CDS YP_907125.1 118618793 4550970 complement(3877363..3878319) 1 NC_008611.1 cytoplasmic protein; this protein may be involved in septum formation (by similarity); cell division protein FtsQ 3878319 ftsQ 4550970 ftsQ Mycobacterium ulcerans Agy99 cell division protein FtsQ YP_907125.1 3877363 R 362242 CDS YP_907126.1 118618794 4550971 complement(3878316..3879782) 1 NC_008611.1 Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis; UDP-N-acetylmuramate--L-alanine ligase 3879782 murC 4550971 murC Mycobacterium ulcerans Agy99 UDP-N-acetylmuramate--L-alanine ligase YP_907126.1 3878316 R 362242 CDS YP_907127.1 118618795 4550972 complement(3879779..3880978) 1 NC_008611.1 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis; undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase 3880978 murG 4550972 murG Mycobacterium ulcerans Agy99 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase YP_907127.1 3879779 R 362242 CDS YP_907128.1 118618796 4550973 complement(3880975..3882606) 1 NC_008611.1 membrane protein; function unknown function in cell division; FtsW-like protein FtsW 3882606 ftsW 4550973 ftsW Mycobacterium ulcerans Agy99 FtsW-like protein FtsW YP_907128.1 3880975 R 362242 CDS YP_907129.1 118618797 4550974 complement(3882613..3884079) 1 NC_008611.1 UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase 3884079 murD 4550974 murD Mycobacterium ulcerans Agy99 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase YP_907129.1 3882613 R 362242 CDS YP_907130.1 118618798 4550975 complement(3884081..3885160) 1 NC_008611.1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; phospho-N-acetylmuramoyl-pentapeptide- transferase 3885160 mraY 4550975 mraY Mycobacterium ulcerans Agy99 phospho-N-acetylmuramoyl-pentapeptide- transferase YP_907130.1 3884081 R 362242 CDS YP_907131.1 118618799 4550976 complement(3885157..3886734) 1 NC_008611.1 Detected in the membrane fraction by proteomics.; membrane protein; involved in cell wall formation; peptidoglycan biosynthesis.; UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6- diaminopimelate-D-alanyl-D-alanyl ligase MurF 3886734 murF 4550976 murF Mycobacterium ulcerans Agy99 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6- diaminopimelate-D-alanyl-D-alanyl ligase MurF YP_907131.1 3885157 R 362242 CDS YP_907132.1 118618800 4550977 complement(3886731..3888410) 1 NC_008611.1 involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate; UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase 3888410 murE 4550977 murE Mycobacterium ulcerans Agy99 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase YP_907132.1 3886731 R 362242 CDS YP_907133.1 118618801 4550978 complement(3888660..3890477) 1 NC_008611.1 membrane protein; PE-PGRS family protein 3890477 4550978 MUL_3507 Mycobacterium ulcerans Agy99 PE-PGRS family protein YP_907133.1 3888660 R 362242 CDS YP_907134.1 118618802 4550979 complement(3890728..3892803) 1 NC_008611.1 membrane protein; involved in peptidoglycan biosynthesis.; penicillin-binding membrane protein PbpB 3892803 pbpB 4550979 pbpB Mycobacterium ulcerans Agy99 penicillin-binding membrane protein PbpB YP_907134.1 3890728 R 362242 CDS YP_907135.1 118618803 4550980 complement(3892800..3894071) 1 NC_008611.1 membrane protein; proline rich membrane protein 3894071 4550980 MUL_3509 Mycobacterium ulcerans Agy99 proline rich membrane protein YP_907135.1 3892800 R 362242 CDS YP_907136.1 118618804 4550981 complement(3894068..3895255) 1 NC_008611.1 cytoplasmic protein; S-adenosyl-methyltransferase MraW 3895255 mraW 4550981 mraW Mycobacterium ulcerans Agy99 S-adenosyl-methyltransferase MraW YP_907136.1 3894068 R 362242 CDS YP_907137.1 118618805 4552658 complement(3895257..3895688) 1 NC_008611.1 MraZ; UPF0040; crystal structure shows similarity to AbrB; cell division protein MraZ 3895688 4552658 MUL_3511 Mycobacterium ulcerans Agy99 cell division protein MraZ YP_907137.1 3895257 R 362242 CDS YP_907138.1 118618806 4552659 complement(3896097..3896501) 1 NC_008611.1 membrane protein; hypothetical protein 3896501 4552659 MUL_3512 Mycobacterium ulcerans Agy99 hypothetical protein YP_907138.1 3896097 R 362242 CDS YP_907139.1 118618807 4552660 3896804..3897442 1 NC_008611.1 cytoplasmic protein; function unknown but contains acyl-CoA N- acyltransferase superfamily domain; hypothetical protein 3897442 4552660 MUL_3513 Mycobacterium ulcerans Agy99 hypothetical protein YP_907139.1 3896804 D 362242 CDS YP_907140.1 118618808 4552661 3897592..3898239 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; lipoprotein LppM 3898239 lppM 4552661 lppM Mycobacterium ulcerans Agy99 lipoprotein LppM YP_907140.1 3897592 D 362242 CDS YP_907141.1 118618809 4552662 complement(3898285..3899181) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3899181 4552662 MUL_3515 Mycobacterium ulcerans Agy99 hypothetical protein YP_907141.1 3898285 R 362242 CDS YP_907142.1 118618810 4552663 3899503..3900525 1 NC_008611.1 Detected in the membrane fraction by proteomics.; cytoplasmic protein; involved in lipid biosynthesis.; geranylgeranyl pyrophosphate synthetase IdsA2 3900525 idsA2 4552663 idsA2 Mycobacterium ulcerans Agy99 geranylgeranyl pyrophosphate synthetase IdsA2 YP_907142.1 3899503 D 362242 CDS YP_907143.1 118618811 4552664 3900662..3902110 1 NC_008611.1 membrane protein; hypothetical protein 3902110 4552664 MUL_3517 Mycobacterium ulcerans Agy99 hypothetical protein YP_907143.1 3900662 D 362242 CDS YP_907144.1 118618812 4552665 complement(3902148..3902552) 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; regulatory protein 3902552 4552665 MUL_3518 Mycobacterium ulcerans Agy99 regulatory protein YP_907144.1 3902148 R 362242 CDS YP_907145.1 118618813 4552666 3902643..3903938 1 NC_008611.1 membrane protein; involved in signal transduction (via phosphorylation); transmembrane serine/threonine-protein kinase L PknL 3903938 pknL 4552666 pknL Mycobacterium ulcerans Agy99 transmembrane serine/threonine-protein kinase L PknL YP_907145.1 3902643 D 362242 CDS YP_907146.1 118618814 4552667 3904610..3905941 1 NC_008611.1 cytoplasmic protein; required for the transposition of the insertion element IS2606.; transposase for IS2606 3905941 4552667 MUL_3520 Mycobacterium ulcerans Agy99 transposase for IS2606 YP_907146.1 3904610 D 362242 CDS YP_907147.1 118618815 4552669 complement(3907143..3908198) 1 NC_008611.1 cytoplasmic protein; HMGR is a tightly regulated enzyme, which catalyzes the synthesis of coenzyme a and mevalonate in isoprenoid synthesis. in mammals, this is the rate limiting committed step in cholesterol biosynthesis. bacteria, such as pseudomonas mevalonii, which rely solely on mevalonate for their carbon source, catalyze the reverse reaction, using an NAD-dependent HMGR to deacetylate mevalonate into 3- hydroxy-3-methylglutaryl-CoA.; hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase 3908198 4552669 MUL_3522 Mycobacterium ulcerans Agy99 hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase YP_907147.1 3907143 R 362242 CDS YP_907148.1 118618816 4552670 complement(3908222..3909334) 1 NC_008611.1 membrane protein; part of the mevalonate pathway for isoprenoid synthesis. possible regulatory role in mevalonate metabolism. converts (R)-5-phosphomevalonate to (R)-5- diphosphomevalonate.; phosphomevalonate kinase 3909334 4552670 MUL_3523 Mycobacterium ulcerans Agy99 phosphomevalonate kinase YP_907148.1 3908222 R 362242 CDS YP_907149.1 118618817 4552671 complement(3909331..3910341) 1 NC_008611.1 cytoplasmic protein; key enzyme in isoprenoid synthesis. converts (R)-5- diphosphomevalonate to phosphate + isopentenyl diphosphate + CO(2); diphosphomevalonate decarboxylase 3910341 4552671 MUL_3524 Mycobacterium ulcerans Agy99 diphosphomevalonate decarboxylase YP_907149.1 3909331 R 362242 CDS YP_907150.1 118618818 4552672 complement(3910338..3911417) 1 NC_008611.1 cytoplasmic protein; converts (R)-mevalonate to (R)-5-phosphomevalonate (ATP dependant); mevalonate kinase, Erg12 3911417 erg12 4552672 erg12 Mycobacterium ulcerans Agy99 mevalonate kinase, Erg12 YP_907150.1 3910338 R 362242 CDS YP_907151.1 118618819 4552674 complement(3911690..3912736) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 3912736 4552674 MUL_3527 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_907151.1 3911690 R 362242 CDS YP_907152.1 118618820 4553928 3916481..3917482 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; involved in fatty acid biosynthesis. catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl- acp. kas III catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. possesses both acetoacetyl-acp synthase and acetyl transacylase activities [catalytic activity: acyl- [acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]]; 3-oxoacyl-[acyl-carrier-protein] synthase III, FabH_1 3917482 fabH_1 4553928 fabH_1 Mycobacterium ulcerans Agy99 3-oxoacyl-[acyl-carrier-protein] synthase III, FabH_1 YP_907152.1 3916481 D 362242 CDS YP_907153.1 118618821 4553930 complement(3919269..3920657) 1 NC_008611.1 cytoplasmic protein; involved in chorismate biosynthesis; 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase AroG_1 3920657 aroG_1 4553930 aroG_1 Mycobacterium ulcerans Agy99 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase AroG_1 YP_907153.1 3919269 R 362242 CDS YP_907154.1 118618822 4553931 complement(3920706..3921185) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3921185 4553931 MUL_3534 Mycobacterium ulcerans Agy99 hypothetical protein YP_907154.1 3920706 R 362242 CDS YP_907155.1 118618823 4553932 complement(3921169..3922008) 1 NC_008611.1 membrane protein; hypothetical protein 3922008 4553932 MUL_3535 Mycobacterium ulcerans Agy99 hypothetical protein YP_907155.1 3921169 R 362242 CDS YP_907156.1 118618824 4553933 3922153..3923436 1 NC_008611.1 membrane protein; hypothetical protein 3923436 4553933 MUL_3536 Mycobacterium ulcerans Agy99 hypothetical protein YP_907156.1 3922153 D 362242 CDS YP_907157.1 118618825 4553934 complement(3923437..3924168) 1 NC_008611.1 Detected in the membrane fraction by proteomics (2D- LC-MS/MS); membrane protein; transfer of fatty acyl groups; 1-acylglycerol-3-phosphate O-acyltransferase 3924168 4553934 MUL_3537 Mycobacterium ulcerans Agy99 1-acylglycerol-3-phosphate O-acyltransferase YP_907157.1 3923437 R 362242 CDS YP_907158.1 118618826 4553935 complement(3924256..3924645) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3924645 4553935 MUL_3538 Mycobacterium ulcerans Agy99 hypothetical protein YP_907158.1 3924256 R 362242 CDS YP_907159.1 118618827 4553936 complement(3924642..3925793) 1 NC_008611.1 cytoplasmic protein; function unknown but domain identity suggests it is an anion-transporting ATPase.; hypothetical protein 3925793 4553936 MUL_3539 Mycobacterium ulcerans Agy99 hypothetical protein YP_907159.1 3924642 R 362242 CDS YP_907160.1 118618828 4553937 complement(3925913..3926347) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3926347 4553937 MUL_3540 Mycobacterium ulcerans Agy99 hypothetical protein YP_907160.1 3925913 R 362242 CDS YP_907161.1 118618829 4553938 complement(3926444..3926833) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3926833 4553938 MUL_3541 Mycobacterium ulcerans Agy99 hypothetical protein YP_907161.1 3926444 R 362242 CDS YP_907162.1 118618830 4553939 3927041..3928843 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; function unknown, but involved in lipid metabolism.; long-chain-fatty-acid-CoA ligase FadD15 3928843 fadD15 4553939 fadD15 Mycobacterium ulcerans Agy99 long-chain-fatty-acid-CoA ligase FadD15 YP_907162.1 3927041 D 362242 CDS YP_907163.1 118618831 4553940 complement(3928911..3930068) 1 NC_008611.1 cytoplasmic protein; glycosyltransferase 3930068 4553940 MUL_3543 Mycobacterium ulcerans Agy99 glycosyltransferase YP_907163.1 3928911 R 362242 CDS YP_907164.1 118618832 4553942 complement(3931010..3932176) 1 NC_008611.1 secreted protein; hypothetical protein 3932176 4553942 MUL_3545 Mycobacterium ulcerans Agy99 hypothetical protein YP_907164.1 3931010 R 362242 CDS YP_907165.1 118618833 4553943 complement(3932364..3932618) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3932618 4553943 MUL_3546 Mycobacterium ulcerans Agy99 hypothetical protein YP_907165.1 3932364 R 362242 CDS YP_907166.1 118618834 4554545 complement(3934890..3935993) 1 NC_008611.1 Catalyzes the conversion of N-(5-phospho-D-ribosyl)-anthranilate and diphosphate to anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate; anthranilate phosphoribosyltransferase 3935993 trpD 4554545 trpD Mycobacterium ulcerans Agy99 anthranilate phosphoribosyltransferase YP_907166.1 3934890 R 362242 CDS YP_907167.1 118618835 4554546 3936144..3936755 1 NC_008611.1 cytoplasmic protein; thought to be involved in aerobic respiration.; cytochrome C oxidase (subunit III) CtaE 3936755 ctaE 4554546 ctaE Mycobacterium ulcerans Agy99 cytochrome C oxidase (subunit III) CtaE YP_907167.1 3936144 D 362242 CDS YP_907168.1 118618836 4554547 3936808..3937713 1 NC_008611.1 membrane protein; plays a role in aerobic respiration; ubiquinol-cytochrome C reductase QcrC 3937713 qcrC 4554547 qcrC Mycobacterium ulcerans Agy99 ubiquinol-cytochrome C reductase QcrC YP_907168.1 3936808 D 362242 CDS YP_907169.1 118618837 4554548 3937710..3938894 1 NC_008611.1 Detected in the membrane fraction by proteomics (2D- LC-MS/MS) Also detected in the cytoplasmic fraction by 2D- LC-MS/MS; membrane protein; role in respiration; Rieske iron-sulfur protein QcrA 3938894 qcrA 4554548 qcrA Mycobacterium ulcerans Agy99 Rieske iron-sulfur protein QcrA YP_907169.1 3937710 D 362242 CDS YP_907170.1 118618838 4554549 3938891..3940576 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; role in respiration; ubiquinol-cytochrome C reductase QcrB 3940576 qcrB 4554549 qcrB Mycobacterium ulcerans Agy99 ubiquinol-cytochrome C reductase QcrB YP_907170.1 3938891 D 362242 CDS YP_907171.1 118618839 4554550 complement(3941022..3941660) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; transmembrane protein 3941660 4554550 MUL_3554 Mycobacterium ulcerans Agy99 transmembrane protein YP_907171.1 3941022 R 362242 CDS YP_907172.1 118618840 4554551 complement(3941660..3942607) 1 NC_008611.1 membrane protein; membrane protein MmpS3 3942607 mmpS3 4554551 mmpS3 Mycobacterium ulcerans Agy99 membrane protein MmpS3 YP_907172.1 3941660 R 362242 CDS YP_907173.1 118618841 4554552 complement(3942790..3943209) 1 NC_008611.1 cytoplasmic protein; integral membrane protein 3943209 4554552 MUL_3556 Mycobacterium ulcerans Agy99 integral membrane protein YP_907173.1 3942790 R 362242 CDS YP_907174.1 118618842 4554553 complement(3943218..3944321) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; involved in aerobic respiration. subunit I and II form the functional core of the enzyme complex. electrons originating in cytochrome C are transferred via HemE A and Cu(A) to the binuclear center formed by HemE A3 and Cu(B) (by similarity); transmembrane cytochrome C oxidase (subunit II) CtaC 3944321 ctaC 4554553 ctaC Mycobacterium ulcerans Agy99 transmembrane cytochrome C oxidase (subunit II) CtaC YP_907174.1 3943218 R 362242 CDS YP_907175.1 118618843 4554554 3944718..3946712 1 NC_008611.1 cytoplasmic protein; asparagine biosynthesis; asparagine synthetase AsnB 3946712 asnB 4554554 asnB Mycobacterium ulcerans Agy99 asparagine synthetase AsnB YP_907175.1 3944718 D 362242 CDS YP_907176.1 118618844 4554555 complement(3946725..3947699) 1 NC_008611.1 Detected in the cytoplamic fraction by LCMSMS. Also detected in the membrane fraction by proteomics (2D-LC- MS/MS); cytoplasmic protein; phosphorylation of carbohydrates; carbohydrate kinase CbhK 3947699 cbhK 4554555 cbhK Mycobacterium ulcerans Agy99 carbohydrate kinase CbhK YP_907176.1 3946725 R 362242 CDS YP_907177.1 118618845 4554556 3947938..3948579 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); cytoplasmic protein; hypothetical protein 3948579 4554556 MUL_3560 Mycobacterium ulcerans Agy99 hypothetical protein YP_907177.1 3947938 D 362242 CDS YP_907178.1 118618846 4554557 complement(3948620..3948976) 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; function unknown but domain identity shows similarity to the HesB gene (function unknown) but which is expressed only under nitrogen fixation conditions.; hypothetical protein 3948976 4554557 MUL_3561 Mycobacterium ulcerans Agy99 hypothetical protein YP_907178.1 3948620 R 362242 CDS YP_907179.1 118618847 4554558 complement(3949063..3950139) 1 NC_008611.1 membrane protein; function unknown role in carbohydrate transport and metabolism; glycerate kinase 3950139 4554558 MUL_3562 Mycobacterium ulcerans Agy99 glycerate kinase YP_907179.1 3949063 R 362242 CDS YP_907180.1 118618848 4554559 3950302..3951006 1 NC_008611.1 membrane protein; transmembrane protein 3951006 4554559 MUL_3563 Mycobacterium ulcerans Agy99 transmembrane protein YP_907180.1 3950302 D 362242 CDS YP_907181.1 118618849 4554560 3951035..3951595 1 NC_008611.1 cytoplasmic protein; involved in cobalamin biosynthesis.; bifunctional cobalamin biosynthesis protein CobU 3951595 cobU 4554560 cobU Mycobacterium ulcerans Agy99 bifunctional cobalamin biosynthesis protein CobU YP_907181.1 3951035 D 362242 CDS YP_907182.1 118618850 4554561 3951592..3952668 1 NC_008611.1 catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide and 5,6-dimethylbenzimidazole; nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase 3952668 cobT 4554561 cobT Mycobacterium ulcerans Agy99 nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase YP_907182.1 3951592 D 362242 CDS YP_907183.1 118618851 4554562 3952665..3953423 1 NC_008611.1 catalyzes the formation of adenosylcobalamin from Ado-cobinamide-GDP and alpha-ribazole; cobalamin synthase 3953423 cobS 4554562 cobS Mycobacterium ulcerans Agy99 cobalamin synthase YP_907183.1 3952665 D 362242 CDS YP_907184.1 118618852 4553401 complement(3953656..3954282) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; C-term transposase for IS2404 3954282 4553401 MUL_3567 Mycobacterium ulcerans Agy99 C-term transposase for IS2404 YP_907184.1 3953656 R 362242 CDS YP_907185.1 118618853 4553402 complement(3954352..3954702) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; N-term transposase for IS2404 3954702 4553402 MUL_3568 Mycobacterium ulcerans Agy99 N-term transposase for IS2404 YP_907185.1 3954352 R 362242 CDS YP_907186.1 118618854 4553403 3955072..3956484 1 NC_008611.1 membrane protein; function unknown but domain identity with chloride channel superfamily; hypothetical protein 3956484 4553403 MUL_3569 Mycobacterium ulcerans Agy99 hypothetical protein YP_907186.1 3955072 D 362242 CDS YP_907187.1 118618855 4553404 complement(3956476..3957582) 1 NC_008611.1 catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids; branched-chain amino acid aminotransferase 3957582 ilvE 4553404 ilvE Mycobacterium ulcerans Agy99 branched-chain amino acid aminotransferase YP_907187.1 3956476 R 362242 CDS YP_907188.1 118618856 4553405 complement(3957636..3958739) 1 NC_008611.1 catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein; glycine cleavage system aminomethyltransferase T 3958739 gcvT 4553405 gcvT Mycobacterium ulcerans Agy99 glycine cleavage system aminomethyltransferase T YP_907188.1 3957636 R 362242 CDS YP_907189.1 118618857 4553407 3959940..3961499 1 NC_008611.1 catalyzes the removal of N-terminal amino acids preferably leucine from various peptides; leucyl aminopeptidase 3961499 pepB 4553407 pepB Mycobacterium ulcerans Agy99 leucyl aminopeptidase YP_907189.1 3959940 D 362242 CDS YP_907190.1 118618858 4553408 complement(3961962..3963746) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; thought to be involved in detoxification reactions following oxidative damage to lipids.; short chain dehydrogenase 3963746 ephD 4553408 ephD Mycobacterium ulcerans Agy99 short chain dehydrogenase YP_907190.1 3961962 R 362242 CDS YP_907191.1 118618859 4553409 3963975..3965741 1 NC_008611.1 Detected in the cytoplasmic, the extracellular matrix, and the membrane fraction by proteomics.; cytoplasmic protein; involved in tricarboxylic acid cycle; converts 2- oxoglutarate to succinyl-CoA and CO2; dihydrolipoamide acetyltransferase 3965741 sucB 4553409 sucB Mycobacterium ulcerans Agy99 dihydrolipoamide acetyltransferase YP_907191.1 3963975 D 362242 CDS YP_907192.1 118618860 4553410 3965746..3966657 1 NC_008611.1 function unknown but domain identity with NAD dependent sugar epimerases; hypothetical protein 3966657 4553410 MUL_3576 Mycobacterium ulcerans Agy99 hypothetical protein YP_907192.1 3965746 D 362242 CDS YP_907193.1 118618861 4553411 complement(3966443..3967684) 1 NC_008611.1 membrane protein; probably involved in active transport of substrate across the membrane (export) responsible for energy coupling to the transport system.; ATP-binding protein ABC transporter 3967684 4553411 MUL_3577 Mycobacterium ulcerans Agy99 ATP-binding protein ABC transporter YP_907193.1 3966443 R 362242 CDS YP_907194.1 118618862 4553413 3969592..3970638 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 3970638 4553413 MUL_3579 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_907194.1 3969592 D 362242 CDS YP_907195.1 118618863 4553366 complement(3971923..3972276) 1 NC_008611.1 cytoplasmic protein; DNA integration. this sequence contains a DNA breaking-rejoining catalytic core found in phage integrase genes.; phage-related integrase 3972276 4553366 MUL_3581 Mycobacterium ulcerans Agy99 phage-related integrase YP_907195.1 3971923 R 362242 CDS YP_907196.1 118618864 4553367 complement(3972570..3973187) 1 NC_008611.1 membrane protein; hypothetical protein 3973187 4553367 MUL_3582 Mycobacterium ulcerans Agy99 hypothetical protein YP_907196.1 3972570 R 362242 CDS YP_907197.1 118618865 4553368 complement(3973525..3973791) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 3973791 4553368 MUL_5087 Mycobacterium ulcerans Agy99 hypothetical protein YP_907197.1 3973525 R 362242 CDS YP_907198.1 118618866 4553369 3974228..3975274 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 3975274 4553369 MUL_3584 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_907198.1 3974228 D 362242 CDS YP_907199.1 118618867 4553371 3975756..3976088 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; hypothetical protein 3976088 4553371 MUL_3585 Mycobacterium ulcerans Agy99 hypothetical protein YP_907199.1 3975756 D 362242 CDS YP_907200.1 118618868 4553372 3976103..3976528 1 NC_008611.1 membrane protein; hypothetical protein 3976528 4553372 MUL_3586 Mycobacterium ulcerans Agy99 hypothetical protein YP_907200.1 3976103 D 362242 CDS YP_907201.1 118618869 4553373 3976661..3978172 1 NC_008611.1 membrane protein; function unknown, hydrolyzes peptides and/or proteins.; lipoprotein aminopeptidase LpqL 3978172 lpqL 4553373 lpqL Mycobacterium ulcerans Agy99 lipoprotein aminopeptidase LpqL YP_907201.1 3976661 D 362242 CDS YP_907202.1 118618870 4553375 3979755..3981248 1 NC_008611.1 secreted protein; function unknown, possibly hydrolyzes peptides and/or proteins.; lipoprotein peptidase LpqM 3981248 lpqM 4553375 lpqM Mycobacterium ulcerans Agy99 lipoprotein peptidase LpqM YP_907202.1 3979755 D 362242 CDS YP_907203.1 118618871 4553376 complement(3981279..3984515) 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; membrane protein; function unknown, but may be involved in efflux system (probably sugar or drug transport); transmembrane transport protein 3984515 4553376 MUL_3590 Mycobacterium ulcerans Agy99 transmembrane transport protein YP_907203.1 3981279 R 362242 CDS YP_907204.1 118618872 4553377 3985251..3986297 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 3986297 4553377 MUL_3591 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_907204.1 3985251 D 362242 CDS YP_907205.1 118618873 4553379 3988189..3989235 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 3989235 4553379 MUL_3593 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_907205.1 3988189 D 362242 CDS YP_907206.1 118618874 4553380 3989272..3990798 1 NC_008611.1 cytoplasmic protein; function unknown but contains a N-term CheY-like response regulator receiver domain and C-term adenylyl/guanylyl cyclase catalytic domain.; adenylylate/guanylate cyclase 3990798 4553380 MUL_3594 Mycobacterium ulcerans Agy99 adenylylate/guanylate cyclase YP_907206.1 3989272 D 362242 CDS YP_907207.1 118618875 4553381 complement(3990791..3991105) 1 NC_008611.1 membrane protein; hypothetical protein 3991105 4553381 MUL_3595 Mycobacterium ulcerans Agy99 hypothetical protein YP_907207.1 3990791 R 362242 CDS YP_907208.1 118618876 4553297 complement(3991153..3991377) 1 NC_008611.1 membrane protein; hypothetical protein 3991377 4553297 MUL_3596 Mycobacterium ulcerans Agy99 hypothetical protein YP_907208.1 3991153 R 362242 CDS YP_907209.1 118618877 4553298 3991479..3992822 1 NC_008611.1 cytoplasmic protein; function unknown but has two TetR DNA-binding domains; putative regulatory protein 3992822 4553298 MUL_3597 Mycobacterium ulcerans Agy99 putative regulatory protein YP_907209.1 3991479 D 362242 CDS YP_907210.1 118618878 4553300 complement(3993365..3994192) 1 NC_008611.1 catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine; phosphomethylpyrimidine kinase 3994192 thiD 4553300 thiD Mycobacterium ulcerans Agy99 phosphomethylpyrimidine kinase YP_907210.1 3993365 R 362242 CDS YP_907211.1 118618879 4553301 complement(3994189..3995829) 1 NC_008611.1 required for the synthesis of the hydromethylpyrimidine moiety of thiamine; thiamine biosynthesis protein ThiC 3995829 thiC 4553301 thiC Mycobacterium ulcerans Agy99 thiamine biosynthesis protein ThiC YP_907211.1 3994189 R 362242 CDS YP_907212.1 118618880 4553302 3995829..3996749 1 NC_008611.1 cytoplasmic protein; function unknown but may be involved in signal transduction pathway as it contains a PAS-like central senor domain and an Antar domain.; putative regulatory protein 3996749 4553302 MUL_3601 Mycobacterium ulcerans Agy99 putative regulatory protein YP_907212.1 3995829 D 362242 CDS YP_907213.1 118618881 4553303 3996880..3997275 1 NC_008611.1 cytoplasmic protein; function unknown but domain identity shared with the anti-sigma factor antagonist superfamily SpoIIAA; anti sigma factor antagonist 3997275 4553303 MUL_3602 Mycobacterium ulcerans Agy99 anti sigma factor antagonist YP_907213.1 3996880 D 362242 CDS YP_907214.1 118618882 4553305 complement(4001165..4001443) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 4001443 4553305 MUL_3604 Mycobacterium ulcerans Agy99 hypothetical protein YP_907214.1 4001165 R 362242 CDS YP_907215.1 118618883 4553307 4004641..4005975 1 NC_008611.1 cytoplasmic protein; required for the transposition of the insertion element IS2606.; transposase for IS2606 4005975 4553307 MUL_3606 Mycobacterium ulcerans Agy99 transposase for IS2606 YP_907215.1 4004641 D 362242 CDS YP_907216.1 118618884 4553310 4009684..4011018 1 NC_008611.1 cytoplasmic protein; required for the transposition of the insertion element IS2606.; transposase for IS2606 4011018 4553310 MUL_3609 Mycobacterium ulcerans Agy99 transposase for IS2606 YP_907216.1 4009684 D 362242 CDS YP_907217.1 118618885 4553311 complement(4011196..4012575) 1 NC_008611.1 Catalyzes a two-step reaction, first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase 4012575 glyS 4553311 glyS Mycobacterium ulcerans Agy99 glycyl-tRNA synthetase YP_907217.1 4011196 R 362242 CDS YP_907218.1 118618886 4553312 4012780..4013175 1 NC_008611.1 cytoplasmic protein; involved in transcriptional mechanism.; ArsR family transcriptional regulator 4013175 4553312 MUL_3611 Mycobacterium ulcerans Agy99 ArsR family transcriptional regulator YP_907218.1 4012780 D 362242 CDS YP_907219.1 118618887 4553277 4013172..4013585 1 NC_008611.1 cytoplasmic protein; acts as a global negative controlling element, employing fe(2+) as a cofactor to bind the operator of the repressed genes. regulates the expression of several outer- membrane proteins including the iron transport operon (by similarity); ferric uptake regulation protein FurB 4013585 furB 4553277 furB Mycobacterium ulcerans Agy99 ferric uptake regulation protein FurB YP_907219.1 4013172 D 362242 CDS YP_907220.1 118618888 4553278 complement(4013582..4014022) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 4014022 4553278 MUL_3613 Mycobacterium ulcerans Agy99 hypothetical protein YP_907220.1 4013582 R 362242 CDS YP_907221.1 118618889 4553279 complement(4014022..4014912) 1 NC_008611.1 catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate; undecaprenyl pyrophosphate synthase 4014912 4553279 MUL_3614 Mycobacterium ulcerans Agy99 undecaprenyl pyrophosphate synthase YP_907221.1 4014022 R 362242 CDS YP_907222.1 118618890 4553280 complement(4014905..4015702) 1 NC_008611.1 involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA; DNA repair protein RecO 4015702 recO 4553280 recO Mycobacterium ulcerans Agy99 DNA repair protein RecO YP_907222.1 4014905 R 362242 CDS YP_907223.1 118618891 4553281 4015764..4017263 1 NC_008611.1 catalyzes the hydrolysis of a monocarboxylic acid amid to form a monocarboxylate and ammonia; amidase 4017263 amiA2 4553281 amiA2 Mycobacterium ulcerans Agy99 amidase YP_907223.1 4015764 D 362242 CDS YP_907224.1 118618892 4553282 complement(4017260..4018162) 1 NC_008611.1 Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome; GTP-binding protein Era 4018162 era 4553282 era Mycobacterium ulcerans Agy99 GTP-binding protein Era YP_907224.1 4017260 R 362242 CDS YP_907225.1 118618893 4553283 complement(4018152..4018382) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 4018382 4553283 MUL_3618 Mycobacterium ulcerans Agy99 hypothetical protein YP_907225.1 4018152 R 362242 CDS YP_907226.1 118618894 4553285 complement(4019671..4020207) 1 NC_008611.1 cytoplasmic protein; putative metalloprotease 4020207 4553285 MUL_3620 Mycobacterium ulcerans Agy99 putative metalloprotease YP_907226.1 4019671 R 362242 CDS YP_907227.1 118618895 4553286 complement(4020226..4021284) 1 NC_008611.1 cytoplasmic protein; PhoH-like protein PhoH1 4021284 phoH1 4553286 phoH1 Mycobacterium ulcerans Agy99 PhoH-like protein PhoH1 YP_907227.1 4020226 R 362242 CDS YP_907228.1 118618896 4553287 complement(4021352..4022074) 1 NC_008611.1 cytoplasmic protein; function unknown but contains tetracycline repressor-like C-terminal superfamily domain.; putative regulatory protein 4022074 4553287 MUL_3622 Mycobacterium ulcerans Agy99 putative regulatory protein YP_907228.1 4021352 R 362242 CDS YP_907229.1 118618897 4553289 4023113..4023622 1 NC_008611.1 cytoplasmic protein; hypothetical protein 4023622 4553289 MUL_3624 Mycobacterium ulcerans Agy99 hypothetical protein YP_907229.1 4023113 D 362242 CDS YP_907230.1 118618898 4553290 complement(4023645..4024406) 1 NC_008611.1 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase; 16S ribosomal RNA methyltransferase RsmE 4024406 4553290 MUL_3625 Mycobacterium ulcerans Agy99 16S ribosomal RNA methyltransferase RsmE YP_907230.1 4023645 R 362242 CDS YP_907231.1 118618899 4553291 complement(4024435..4025571) 1 NC_008611.1 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion; chaperone protein DnaJ 4025571 dnaJ2 4553291 dnaJ2 Mycobacterium ulcerans Agy99 chaperone protein DnaJ YP_907231.1 4024435 R 362242 CDS YP_907232.1 118618900 4553292 complement(4025646..4026677) 1 NC_008611.1 Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons; heat-inducible transcription repressor 4026677 hrcA 4553292 hrcA Mycobacterium ulcerans Agy99 heat-inducible transcription repressor YP_907232.1 4025646 R 362242 CDS YP_907233.1 118618901 4553293 4026965..4027264 1 NC_008611.1 cytoplasmic protein; hypothetical protein 4027264 4553293 MUL_3628 Mycobacterium ulcerans Agy99 hypothetical protein YP_907233.1 4026965 D 362242 CDS YP_907234.1 118618902 4553294 4027371..4027958 1 NC_008611.1 cytoplasmic protein; function unknown but contains identity with antioxidant defence protein Ahp; hypothetical protein 4027958 4553294 MUL_3629 Mycobacterium ulcerans Agy99 hypothetical protein YP_907234.1 4027371 D 362242 CDS YP_907235.1 118618903 4553295 4027955..4028854 1 NC_008611.1 cytoplasmic protein; the sigma factor is an initiation factor that promotes attachment of the RNA polymerase to specific initiation sites and then is released. belongs to the sigma-70 factor family, ECF subfamily.; alternative RNA polymerase sigma factor SigJ- like 4028854 4553295 MUL_3630 Mycobacterium ulcerans Agy99 alternative RNA polymerase sigma factor SigJ- like YP_907235.1 4027955 D 362242 CDS YP_907236.1 118618904 4553153 complement(4029686..4033177) 1 NC_008611.1 cytoplasmic protein; involved in the biogenesis of the hydroxyphenyloxazoline-containing siderophore mycobactins. this peptide synthase forms amide bound between the carboxylic acid of salicylate and the alpha-amino group of serine (serine/threonine ligation); phenyloxazoline synthase MbtB 4033177 mbtB 4553153 mbtB Mycobacterium ulcerans Agy99 phenyloxazoline synthase MbtB YP_907236.1 4029686 R 362242 CDS YP_907237.1 118618905 4553154 complement(4033213..4037751) 1 NC_008611.1 cytoplasmic protein; involved in the biogenesis of the hydroxyphenyloxazoline-containing siderophore mycobactins. activates amino acid residues that are incorporated into mycobactin (ligation); non-ribosomal peptide synthetase MbtF 4037751 mbtF 4553154 mbtF Mycobacterium ulcerans Agy99 non-ribosomal peptide synthetase MbtF YP_907237.1 4033213 R 362242 CDS YP_907238.1 118618906 4553155 complement(4037748..4042760) 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; involved in the biogenesis of the hydroxyphenyloxazoline-containing siderophore mycobactins. probably activates the two lysine residues that are incorporated into mycobactin (lysine ligation); non-ribosomal peptide synthetase MbtE 4042760 mbtE 4553155 mbtE Mycobacterium ulcerans Agy99 non-ribosomal peptide synthetase MbtE YP_907238.1 4037748 R 362242 CDS YP_907239.1 118618907 4553156 4043035..4043640 1 NC_008611.1 cytoplasmic protein; function unknown but contains acyl-CoA N- acetyltransferase superfamily domain; hypothetical protein 4043640 4553156 MUL_3635 Mycobacterium ulcerans Agy99 hypothetical protein YP_907239.1 4043035 D 362242 CDS YP_907240.1 118618908 4553157 4043750..4044508 1 NC_008611.1 cytoplasmic protein; may be required for the addition of the terminal aa in this Nrp operon; thioesterase 4044508 4553157 MUL_3636 Mycobacterium ulcerans Agy99 thioesterase YP_907240.1 4043750 D 362242 CDS YP_907241.1 118618909 4553158 4044505..4045824 1 NC_008611.1 cytoplasmic protein; involved in the biogenesis of the hydroxyphenyloxazoline-containing siderophore mycobactins.; polyketide synthase MbtC 4045824 mbtC 4553158 mbtC Mycobacterium ulcerans Agy99 polyketide synthase MbtC YP_907241.1 4044505 D 362242 CDS YP_907242.1 118618910 4553159 4045821..4048895 1 NC_008611.1 cytoplasmic protein; involved in the biogenesis of the hydroxyphenyloxazoline-containing siderophore mycobactins.; polyketide synthase MbtD 4048895 mbtD 4553159 mbtD Mycobacterium ulcerans Agy99 polyketide synthase MbtD YP_907242.1 4045821 D 362242 CDS YP_907243.1 118618911 4553160 complement(4048900..4049115) 1 NC_008611.1 cytoplasmic protein; thought to be involved in the biogenesis of the hydroxyphenyloxazoline-containing siderophore mycobactins.; hypothetical protein 4049115 mbtH_1 4553160 mbtH_1 Mycobacterium ulcerans Agy99 hypothetical protein YP_907243.1 4048900 R 362242 CDS YP_907244.1 118618912 4553161 complement(4049096..4050400) 1 NC_008611.1 cytoplasmic protein; involved in the biogenesis of the hydroxyphenyloxazoline-containing siderophore mycobactins. this hydroxylase is possibly required for N-hydroxylation of the two lysine residues at some stage during mycobactin assembly [catalytic activity: L-lysine + O(2) = N6-hydroxy- L-lysine + H(2)O. no information can be found if this enzyme is NADPH dependent or independent]; lysine-N-oxygenase MbtG 4050400 mbtG 4553161 mbtG Mycobacterium ulcerans Agy99 lysine-N-oxygenase MbtG YP_907244.1 4049096 R 362242 CDS YP_907245.1 118618913 4553162 4050636..4052249 1 NC_008611.1 membrane protein; involved in the biogenesis of the hydroxyphenyloxazoline-containing siderophore mycobactins (initiation step of mycobactin chain growth) activates the mycobactin ACP in two half-reactions: activates salicylic acid as acyladenylate (adenylation step) + transfers activated salicylate to the MbtA ACP as a thioester (arylation step); bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 4052249 mbtA 4553162 mbtA Mycobacterium ulcerans Agy99 bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase YP_907245.1 4050636 D 362242 CDS YP_907246.1 118618914 4553163 4052359..4053354 1 NC_008611.1 cytoplasmic protein; involved in the biogenesis of the hydroxyphenyloxazoline-containing siderophore mycobactins. possibly required for N-hydroxylation of the two lysine residues at some stage during mycobactin assembly.; acetyl hydrolase MbtJ 4053354 mbtJ 4553163 mbtJ Mycobacterium ulcerans Agy99 acetyl hydrolase MbtJ YP_907246.1 4052359 D 362242 CDS YP_907247.1 118618915 4553164 4053356..4054216 1 NC_008611.1 membrane protein; short-chain membrane-associated dehydrogenase 4054216 4553164 MUL_3643 Mycobacterium ulcerans Agy99 short-chain membrane-associated dehydrogenase YP_907247.1 4053356 D 362242 CDS YP_907248.1 118618916 4553166 4055176..4055880 1 NC_008611.1 cytoplasmic protein; function unknown. possibly involved in transcriptional mechanism.; putative transcriptional regulator 4055880 4553166 MUL_3645 Mycobacterium ulcerans Agy99 putative transcriptional regulator YP_907248.1 4055176 D 362242 CDS YP_907249.1 118618917 4553167 complement(4055912..4056928) 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; catalyzes the principal conversion of saturated fatty acids to unsaturated fatty acids. thought to convert stearoyl-ACP to oleoyl-ACP by introduction of a cis double bond between carbons delta-9 and delta-10 of the acyl chain [catalytic activity: stearoyl-[acyl-carrier protein] + AH2 + O2 = oleoyl-[acyl-carrier protein] + a + 2 H2O]; acyl-[acyl-carrier protein] desaturase DesA1_1 4056928 desA1_1 4553167 desA1_1 Mycobacterium ulcerans Agy99 acyl-[acyl-carrier protein] desaturase DesA1_1 YP_907249.1 4055912 R 362242 CDS YP_907250.1 118618918 4553168 complement(4057055..4057801) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 4057801 4553168 MUL_3647 Mycobacterium ulcerans Agy99 hypothetical protein YP_907250.1 4057055 R 362242 CDS YP_907251.1 118618919 4553169 complement(4058002..4059363) 1 NC_008611.1 catalyzes conversion of chorismate to salicylate, in mycobactin siderophore construction; requires Mg(2+) for function; salicylate synthase MbtI 4059363 mbtI 4553169 mbtI Mycobacterium ulcerans Agy99 salicylate synthase MbtI YP_907251.1 4058002 R 362242 CDS YP_907252.1 118618920 4553170 4059752..4059961 1 NC_008611.1 cytoplasmic protein; hypothetical protein 4059961 4553170 MUL_3649 Mycobacterium ulcerans Agy99 hypothetical protein YP_907252.1 4059752 D 362242 CDS YP_907253.1 118618921 4553171 4060251..4061486 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; membrane permease 4061486 4553171 MUL_3650 Mycobacterium ulcerans Agy99 membrane permease YP_907253.1 4060251 D 362242 CDS YP_907254.1 118618922 4553114 complement(4061498..4062670) 1 NC_008611.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase 4062670 hemN 4553114 hemN Mycobacterium ulcerans Agy99 coproporphyrinogen III oxidase YP_907254.1 4061498 R 362242 CDS YP_907255.1 118618923 4553115 4063107..4064774 1 NC_008611.1 cytoplasmic protein; generates nitrite from ammonia using oxidized ferredoxin [catalytic activity: ammonia + H(2)O + oh(-) + 3 oxidized ferredoxin = nitrite + 3 reduced ferredoxin] can also act as a sulphite reductase. the sulfite reductases catalyze the reduction of sulfite to sulfide, one step in the biosynthesis of sulfur-containing amino acids and cofactors. this appears to be the only intact nitrite reductase in M. ulcerans.; ferredoxin-dependent nitrite reductase, NirA_2 4064774 nirA_2 4553115 nirA_2 Mycobacterium ulcerans Agy99 ferredoxin-dependent nitrite reductase, NirA_2 YP_907255.1 4063107 D 362242 CDS YP_907256.1 118618924 4553116 4064771..4065520 1 NC_008611.1 catalyzes the reduction of 3'-phosphoadenylyl sulfate into sulfite; phosphoadenosine phosphosulfate reductase 4065520 cysH 4553116 cysH Mycobacterium ulcerans Agy99 phosphoadenosine phosphosulfate reductase YP_907256.1 4064771 D 362242 CDS YP_907257.1 118618925 4553117 4065517..4066191 1 NC_008611.1 membrane protein; function unknown but contains a chelatase superfamily domain. given the presence of other heme- associated CDS in this region and the presence of a chelatase superfamily domain, this CDS may encode a ferrochelatase, catalyzing the last step in HemE biosynthesis.; hypothetical protein 4066191 4553117 MUL_3654 Mycobacterium ulcerans Agy99 hypothetical protein YP_907257.1 4065517 D 362242 CDS YP_907258.1 118618926 4553120 complement(4070337..4071428) 1 NC_008611.1 membrane protein; involved in the active transport across the membrane of multiple sulfur-containing compounds, including sulfate and thiosulfate (import) responsible for energy coupling to the transport system.; sulfate-transport ATP-binding protein ABC transporter CysA1 4071428 cysA1 4553120 cysA1 Mycobacterium ulcerans Agy99 sulfate-transport ATP-binding protein ABC transporter CysA1 YP_907258.1 4070337 R 362242 CDS YP_907259.1 118618927 4553121 complement(4071443..4072261) 1 NC_008611.1 membrane protein; involved in the active transport across the membrane of multiple sulfur-containing compounds, including sulfate and thiosulfate (import) responsible for the translocation of the substrate across the membrane.; sulfate-transport integral membrane protein ABC transporter CysW 4072261 cysW 4553121 cysW Mycobacterium ulcerans Agy99 sulfate-transport integral membrane protein ABC transporter CysW YP_907259.1 4071443 R 362242 CDS YP_907260.1 118618928 4553122 complement(4072258..4073160) 1 NC_008611.1 membrane protein; involved in the active transport across the membrane of multiple sulfur-containing compounds, including sulfate and thiosulfate (import) responsible for the translocation of the substrate across the membrane.; sulfate-transport integral membrane protein ABC transporter CysT 4073160 cysT 4553122 cysT Mycobacterium ulcerans Agy99 sulfate-transport integral membrane protein ABC transporter CysT YP_907260.1 4072258 R 362242 CDS YP_907261.1 118618929 4553123 complement(4073157..4074206) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; involved in the active transport across the membrane of multiple sulfur-containing compounds, including sulfate and thiosulfate (import); sulfate-binding lipoprotein SubI 4074206 subI 4553123 subI Mycobacterium ulcerans Agy99 sulfate-binding lipoprotein SubI YP_907261.1 4073157 R 362242 CDS YP_907262.1 118618930 4553124 complement(4074556..4074750) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 4074750 4553124 MUL_3662 Mycobacterium ulcerans Agy99 hypothetical protein YP_907262.1 4074556 R 362242 CDS YP_907263.1 118618931 4553125 4074826..4076064 1 NC_008611.1 cytoplasmic protein; function unknown, probably involved in cellular metabolism; hypothetical protein 4076064 4553125 MUL_3663 Mycobacterium ulcerans Agy99 hypothetical protein YP_907263.1 4074826 D 362242 CDS YP_907264.1 118618932 4553126 4076135..4078201 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; glycosyl hydrolase 4078201 4553126 MUL_3664 Mycobacterium ulcerans Agy99 glycosyl hydrolase YP_907264.1 4076135 D 362242 CDS YP_907265.1 118618933 4553127 complement(4078219..4078980) 1 NC_008611.1 secreted protein; lipoprotein, LppR 4078980 lppR 4553127 lppR Mycobacterium ulcerans Agy99 lipoprotein, LppR YP_907265.1 4078219 R 362242 CDS YP_907266.1 118618934 4553128 complement(4078992..4079735) 1 NC_008611.1 secreted protein; lipoprotein, LppR_1 4079735 lppR_1 4553128 lppR_1 Mycobacterium ulcerans Agy99 lipoprotein, LppR_1 YP_907266.1 4078992 R 362242 CDS YP_907267.1 118618935 4553129 complement(4079738..4081477) 1 NC_008611.1 binds to the ribosome on the universally-conserved alpha-sarcin loop; GTP-binding protein LepA 4081477 lepA 4553129 lepA Mycobacterium ulcerans Agy99 GTP-binding protein LepA YP_907267.1 4079738 R 362242 CDS YP_907268.1 118618936 4553130 4081745..4082290 1 NC_008611.1 cytoplasmic protein; function unknown but domain identity with plasmid maintenance toxin superfamily; hypothetical protein 4082290 4553130 MUL_3668 Mycobacterium ulcerans Agy99 hypothetical protein YP_907268.1 4081745 D 362242 CDS YP_907269.1 118618937 4553131 complement(4082332..4082760) 1 NC_008611.1 cytoplasmic protein; function unknown but contains 2 Cbs domains; transcriptional regulator 4082760 4553131 MUL_3669 Mycobacterium ulcerans Agy99 transcriptional regulator YP_907269.1 4082332 R 362242 CDS YP_907270.1 118618938 4553132 4082986..4083825 1 NC_008611.1 member of metallo-beta-lactamase family; the purified enzyme from Escherichia coli forms dimeric zinc phosphodiesterase; in Bacillus subtilis this protein is a 3'-tRNA processing endoribonuclease and is essential while in Escherichia coli it is not; associates with two zinc ions; ribonuclease Z 4083825 4553132 MUL_3670 Mycobacterium ulcerans Agy99 ribonuclease Z YP_907270.1 4082986 D 362242 CDS YP_907271.1 118618939 4553133 4083988..4085268 1 NC_008611.1 PE_PGRS2; membrane protein; PE-PGRS family protein 4085268 4553133 MUL_3671 Mycobacterium ulcerans Agy99 PE-PGRS family protein YP_907271.1 4083988 D 362242 CDS YP_907272.1 118618940 4553079 4085372..4086748 1 NC_008611.1 PE_PGRS25; membrane protein; PE-PGRS family protein 4086748 4553079 MUL_3672 Mycobacterium ulcerans Agy99 PE-PGRS family protein YP_907272.1 4085372 D 362242 CDS YP_907273.1 118618941 4553080 complement(4086753..4087592) 1 NC_008611.1 cytoplasmic protein; function unknown but based on domain identity it may cross-link proteins through an acyl-transfer reaction between the gamma-carboxamide group of peptide-bound glutamine and the epsilon-amino group of peptide-bound lysine.; putative transglutaminase-like protein 4087592 4553080 MUL_3673 Mycobacterium ulcerans Agy99 putative transglutaminase-like protein YP_907273.1 4086753 R 362242 CDS YP_907274.1 118618942 4553081 complement(4087592..4088569) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 4088569 4553081 MUL_3674 Mycobacterium ulcerans Agy99 hypothetical protein YP_907274.1 4087592 R 362242 CDS YP_907275.1 118618943 4553082 complement(4088569..4090242) 1 NC_008611.1 cytoplasmic protein; function unknown but contains two glutathione synthetase ATP-binding superfamily domain-like sequences; hypothetical protein 4090242 4553082 MUL_3675 Mycobacterium ulcerans Agy99 hypothetical protein YP_907275.1 4088569 R 362242 CDS YP_907276.1 118618944 4553083 4090381..4090644 1 NC_008611.1 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase; 30S ribosomal protein S20 4090644 rpsT 4553083 rpsT Mycobacterium ulcerans Agy99 30S ribosomal protein S20 YP_907276.1 4090381 D 362242 CDS YP_907277.1 118618945 4553084 complement(4090716..4091693) 1 NC_008611.1 cytoplasmic protein; possible role in DNA replication. two superfamily domains detected. N-term contains P-loop nucleoside triphosphate hydrolase. C-term contains DNA polymerase III, delta subunit.; hypothetical protein 4091693 holA 4553084 holA Mycobacterium ulcerans Agy99 hypothetical protein YP_907277.1 4090716 R 362242 CDS YP_907278.1 118618946 4553085 complement(4091787..4092833) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 4092833 4553085 MUL_3678 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_907278.1 4091787 R 362242 CDS YP_907279.1 118618947 4553086 complement(4093109..4094662) 1 NC_008611.1 membrane protein; function unknown, predicted membrane metal-binding protein; membrane metal-binding protein ComEC 4094662 comEC 4553086 comEC Mycobacterium ulcerans Agy99 membrane metal-binding protein ComEC YP_907279.1 4093109 R 362242 CDS YP_907280.1 118618948 4553087 complement(4094680..4095555) 1 NC_008611.1 membrane protein; function unknown but domain identity suggests ComEA. a family of DNA uptake protein and related DNA- binding proteins involved in DNA replication, recombination, and repair.; membrane protein ComEA 4095555 comEA 4553087 comEA Mycobacterium ulcerans Agy99 membrane protein ComEA YP_907280.1 4094680 R 362242 CDS YP_907281.1 118618949 4553088 4095810..4096976 1 NC_008611.1 Detected in the membrane fraction by proteomics, and in the cytoplamic and extracellular matrix fractions by LCMSMS; cytoplasmic protein; function unknown, but probable involvement in lipid metabolism.; acyl-CoA dehydrogenase FadE17_1 4096976 fadE17_1 4553088 fadE17_1 Mycobacterium ulcerans Agy99 acyl-CoA dehydrogenase FadE17_1 YP_907281.1 4095810 D 362242 CDS YP_907282.1 118618950 4553089 4096984..4098102 1 NC_008611.1 cytoplasmic protein; function unknown, but supposed involvement in lipid metabolism.; acyl-CoA dehydrogenase FadE18_2 4098102 fadE18_2 4553089 fadE18_2 Mycobacterium ulcerans Agy99 acyl-CoA dehydrogenase FadE18_2 YP_907282.1 4096984 D 362242 CDS YP_907283.1 118618951 4553090 4098358..4099458 1 NC_008611.1 membrane protein; function unknown but contains FAD/NAD(P)-binding superfamily domain; hypothetical protein 4099458 4553090 MUL_3683 Mycobacterium ulcerans Agy99 hypothetical protein YP_907283.1 4098358 D 362242 CDS YP_907284.1 118618952 4553092 4101005..4102054 1 NC_008611.1 cytoplasmic protein; function unknown but contains superfamily NAD(P)- binding Rossmann-fold domains; hypothetical protein 4102054 4553092 MUL_3685 Mycobacterium ulcerans Agy99 hypothetical protein YP_907284.1 4101005 D 362242 CDS YP_907285.1 118618953 4553093 4102057..4102833 1 NC_008611.1 membrane protein; hypothetical protein 4102833 4553093 MUL_3686 Mycobacterium ulcerans Agy99 hypothetical protein YP_907285.1 4102057 D 362242 CDS YP_907286.1 118618954 4553094 4103173..4103592 1 NC_008611.1 membrane protein; membrane protein MmpS5_1 4103592 mmpS5_1 4553094 mmpS5_1 Mycobacterium ulcerans Agy99 membrane protein MmpS5_1 YP_907286.1 4103173 D 362242 CDS YP_907287.1 118618955 4553050 4103589..4106510 1 NC_008611.1 membrane protein; function unknown. thought to be involved in lipid transport.; transmembrane transport protein MmpL4_1 4106510 mmpL4_1 4553050 mmpL4_1 Mycobacterium ulcerans Agy99 transmembrane transport protein MmpL4_1 YP_907287.1 4103589 D 362242 CDS YP_907288.1 118618956 4553051 complement(4106546..4107391) 1 NC_008611.1 cytoplasmic protein; function unknown, contains DegV-like superfamily domain; hypothetical protein 4107391 4553051 MUL_3689 Mycobacterium ulcerans Agy99 hypothetical protein YP_907288.1 4106546 R 362242 CDS YP_907289.1 118618957 4553052 complement(4107395..4108150) 1 NC_008611.1 cytoplasmic protein; function unknown but contains esterase/acetylhydrolase superfamily domain; hypothetical protein 4108150 4553052 MUL_3690 Mycobacterium ulcerans Agy99 hypothetical protein YP_907289.1 4107395 R 362242 CDS YP_907290.1 118618958 4553053 complement(4108140..4108814) 1 NC_008611.1 cytoplasmic protein; involved in glycolysis [catalytic activity: 2- phosphoglycerate + 2,3-diphosphoglycerate = 3- phosphoglycerate + 2,3-diphosphoglycerate]; phosphoglycerate mutase, Gpm_1 4108814 gpm_1 4553053 gpm_1 Mycobacterium ulcerans Agy99 phosphoglycerate mutase, Gpm_1 YP_907290.1 4108140 R 362242 CDS YP_907291.1 118618959 4553054 complement(4108811..4109845) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; involved in NAD biosynthesis; catalyzes the reversible adenylation of nicotinate mononucleotide [catalytic activity: ATP + nicotinate ribonucleotide = diphosphate + deamido-NAD(+)] this CDS is a combination of NadD translationally fused at the C-term with an orthologue of Rv2420c. this coupling is not seen in M. marinum nor in other mycobacteria although in other species Rv2420c is immediately d/s of NadD. probably caused by mutational loss of a stop codon.; bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein 4109845 nadD 4553054 nadD Mycobacterium ulcerans Agy99 bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein YP_907291.1 4108811 R 362242 CDS YP_907292.1 118618960 4553056 complement(4111129..4112568) 1 NC_008611.1 cytoplasmic protein; function unknown but contains a von willebrand factor type a conserved domain; hypothetical protein 4112568 4553056 MUL_3694 Mycobacterium ulcerans Agy99 hypothetical protein YP_907292.1 4111129 R 362242 CDS YP_907293.1 118618961 4553057 complement(4112582..4113457) 1 NC_008611.1 Also detected in the membrane fraction by proteomics; cytoplasmic protein; function unknown but contains aaa ATPase domain containing von willebrand factor type a (vWA) domain; hypothetical protein 4113457 4553057 MUL_3695 Mycobacterium ulcerans Agy99 hypothetical protein YP_907293.1 4112582 R 362242 CDS YP_907294.1 118618962 4553058 complement(4113491..4114762) 1 NC_008611.1 Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway; gamma-glutamyl phosphate reductase 4114762 proA 4553058 proA Mycobacterium ulcerans Agy99 gamma-glutamyl phosphate reductase YP_907294.1 4113491 R 362242 CDS YP_907295.1 118618963 4553059 complement(4114855..4116249) 1 NC_008611.1 membrane protein; hypothetical protein 4116249 4553059 MUL_3697 Mycobacterium ulcerans Agy99 hypothetical protein YP_907295.1 4114855 R 362242 CDS YP_907296.1 118618964 4553060 complement(4116246..4118357) 1 NC_008611.1 membrane protein; generates 3,'5'-cyclic (A/G)mp and diphosphate (or pyrophosphate) from (A/G)tp.; adenylate or guanylate cyclase 4118357 4553060 MUL_3698 Mycobacterium ulcerans Agy99 adenylate or guanylate cyclase YP_907296.1 4116246 R 362242 CDS YP_907297.1 118618965 4553061 complement(4118604..4120004) 1 NC_008611.1 cytoplasmic protein; function unknown but domain identity suggests that it may be a mechanosensitive (ms) ion channel protein with a C-term putative cyclic nucleotide (camp or cGMP) binding domain.; hypothetical protein 4120004 4553061 MUL_3699 Mycobacterium ulcerans Agy99 hypothetical protein YP_907297.1 4118604 R 362242 CDS YP_907298.1 118618966 4553063 4122738..4124072 1 NC_008611.1 cytoplasmic protein; required for the transposition of the insertion element IS2606.; transposase for IS2606 4124072 4553063 MUL_3702 Mycobacterium ulcerans Agy99 transposase for IS2606 YP_907298.1 4122738 D 362242 CDS YP_907299.1 118618967 4553064 4124507..4125553 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 4125553 4553064 MUL_3703 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_907299.1 4124507 D 362242 CDS YP_907300.1 118618968 4553065 4125622..4126998 1 NC_008611.1 PE_PGRS33_1; membrane protein; function unknown. seems to influence both cell surface interactions among mycobacteria and the interactions of bacteria with macrophages; PE-PGRS family protein 4126998 4553065 MUL_3704 Mycobacterium ulcerans Agy99 PE-PGRS family protein YP_907300.1 4125622 D 362242 CDS YP_907301.1 118618969 4553066 complement(4127111..4129153) 1 NC_008611.1 catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers; NAD synthetase 4129153 nadE 4553066 nadE Mycobacterium ulcerans Agy99 NAD synthetase YP_907301.1 4127111 R 362242 CDS YP_907302.1 118618970 4553000 4129463..4130314 1 NC_008611.1 cytoplasmic protein; function unknown, involved in transcriptional mechanism; Sir2-like regulatory protein 4130314 4553000 MUL_3706 Mycobacterium ulcerans Agy99 Sir2-like regulatory protein YP_907302.1 4129463 D 362242 CDS YP_907303.1 118618971 4553002 4131788..4132426 1 NC_008611.1 cytoplasmic protein; function unknown. possibly involved in transcriptional mechanism.; AcrR family transcriptional regulator 4132426 4553002 MUL_3708 Mycobacterium ulcerans Agy99 AcrR family transcriptional regulator YP_907303.1 4131788 D 362242 CDS YP_907304.1 118618972 4553004 complement(4137065..4138171) 1 NC_008611.1 catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis; gamma-glutamyl kinase 4138171 proB 4553004 proB Mycobacterium ulcerans Agy99 gamma-glutamyl kinase YP_907304.1 4137065 R 362242 CDS YP_907305.1 118618973 4553005 complement(4138171..4139610) 1 NC_008611.1 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication; GTPase ObgE 4139610 obgE 4553005 obgE Mycobacterium ulcerans Agy99 GTPase ObgE YP_907305.1 4138171 R 362242 CDS YP_907306.1 118618974 4553006 complement(4139715..4139981) 1 NC_008611.1 involved in the peptidyltransferase reaction during translation; 50S ribosomal protein L27 4139981 rpmA 4553006 rpmA Mycobacterium ulcerans Agy99 50S ribosomal protein L27 YP_907306.1 4139715 R 362242 CDS YP_907307.1 118618975 4553007 complement(4139999..4140310) 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; involved in translation mechanisms.; 50S ribosomal protein L21 4140310 rplU 4553007 rplU Mycobacterium ulcerans Agy99 50S ribosomal protein L21 YP_907307.1 4139999 R 362242 CDS YP_907308.1 118618976 4553008 complement(4140583..4143549) 1 NC_008611.1 cytoplasmic protein; thought to be involved in several cellular process.; ribonuclease E Rne 4143549 rne 4553008 rne Mycobacterium ulcerans Agy99 ribonuclease E Rne YP_907308.1 4140583 R 362242 CDS YP_907309.1 118618977 4553009 complement(4143876..4144286) 1 NC_008611.1 catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate; nucleoside diphosphate kinase 4144286 ndk 4553009 ndk Mycobacterium ulcerans Agy99 nucleoside diphosphate kinase YP_907309.1 4143876 R 362242 CDS YP_907310.1 118618978 4553010 complement(4144350..4144754) 1 NC_008611.1 membrane protein; hypothetical protein 4144754 4553010 MUL_3717 Mycobacterium ulcerans Agy99 hypothetical protein YP_907310.1 4144350 R 362242 CDS YP_907311.1 118618979 4553011 complement(4144751..4146205) 1 NC_008611.1 cytoplasmic protein; conversion of folates to polyglutamate derivatives. bacteria require folate for the biosynthesis of glycine, methionine, formyl-met-tRNA, thymidylates, purines, and pantothenate [catalytic activity: ATP + {tetrahydrofolyl- [Glu]}(N) + L-glutamate = ADP + phosphate + {tetrahydrofolyl-[Glu]}(n+1)]; folylpolyglutamate synthase protein FolC 4146205 folC 4553011 folC Mycobacterium ulcerans Agy99 folylpolyglutamate synthase protein FolC YP_907311.1 4144751 R 362242 CDS YP_907312.1 118618980 4553012 complement(4146202..4148862) 1 NC_008611.1 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain; valyl-tRNA synthetase 4148862 valS 4553012 valS Mycobacterium ulcerans Agy99 valyl-tRNA synthetase YP_907312.1 4146202 R 362242 CDS YP_907313.1 118618981 4553013 complement(4148937..4149560) 1 NC_008611.1 Detected in the cytoplasm and in the extracellular matrix by proteomics.; cytoplasmic protein; function unknown but N-term contains a bulb-type mannose-specific lectin and C-term contains a LysM, a putative peptidoglycan-binding domain.; hypothetical protein 4149560 4553013 MUL_3720 Mycobacterium ulcerans Agy99 hypothetical protein YP_907313.1 4148937 R 362242 CDS YP_907314.1 118618982 4553014 complement(4149644..4150249) 1 NC_008611.1 membrane protein; hypothetical protein 4150249 4553014 MUL_3721 Mycobacterium ulcerans Agy99 hypothetical protein YP_907314.1 4149644 R 362242 CDS YP_907315.1 118618983 4553015 complement(4150348..4151604) 1 NC_008611.1 Detected in the membrane fraction by proteomics (2D- LC-MS/MS) Also Detected in the extracellular matrix and the cytoplasmic fractions by proteomics.; membrane protein; function unknown but contains potential saccharopine-like dehydrogenase domain; hypothetical protein 4151604 4553015 MUL_3722 Mycobacterium ulcerans Agy99 hypothetical protein YP_907315.1 4150348 R 362242 CDS YP_907316.1 118618984 4552932 complement(4151771..4152415) 1 NC_008611.1 secreted protein; thought to promote the resuscitation and growth of dormant, nongrowing cells. could also stimulate the growth of several other high G+C Gram+ organisms, E.G. mycobacterium avium, mycobacterium bovis (BCG), mycobacterium kansasii, mycobacterium smegmatis.; resuscitation-promoting factor RpfE 4152415 rpfE 4552932 rpfE Mycobacterium ulcerans Agy99 resuscitation-promoting factor RpfE YP_907316.1 4151771 R 362242 CDS YP_907317.1 118618985 4552933 complement(4152947..4153552) 1 NC_008611.1 MobA; links a guanosine 5'-phosphate to molydopterin to form molybdopterin guanine dinucleotide; involved in molybdenum cofactor biosynthesis; molybdopterin-guanine dinucleotide biosynthesis protein A 4153552 mobA 4552933 mobA Mycobacterium ulcerans Agy99 molybdopterin-guanine dinucleotide biosynthesis protein A YP_907317.1 4152947 R 362242 CDS YP_907318.1 118618986 4552934 complement(4153555..4154646) 1 NC_008611.1 catalyzes the coenzyme A dependent formation of succinyl-CoA from 2-oxoglutarate and ferredoxin; 2-oxoglutarate ferredoxin oxidoreductase subunit beta 4154646 porB 4552934 porB Mycobacterium ulcerans Agy99 2-oxoglutarate ferredoxin oxidoreductase subunit beta YP_907318.1 4153555 R 362242 CDS YP_907319.1 118618987 4552935 complement(4154695..4156656) 1 NC_008611.1 Also detected in the membrane fraction by proteomics (2D-LC-MS/MS); cytoplasmic protein; function unknown, probably involved in cellular metabolism.; pyruvate:ferredoxin oxidoreductase, PorA, alpha subunit 4156656 porA 4552935 porA Mycobacterium ulcerans Agy99 pyruvate:ferredoxin oxidoreductase, PorA, alpha subunit YP_907319.1 4154695 R 362242 CDS YP_907320.1 118618988 4552936 complement(4157002..4158300) 1 NC_008611.1 membrane protein; thought to be involved in transport of undeterminated substrate (possibly sugar) across the membrane. responsible for the translocation of the substrate across the membrane.; integral membrane transport protein 4158300 4552936 MUL_3727 Mycobacterium ulcerans Agy99 integral membrane transport protein YP_907320.1 4157002 R 362242 CDS YP_907321.1 118618989 4552937 complement(4158310..4159590) 1 NC_008611.1 binds and unfolds substrates as part of the ClpXP protease; ATP-dependent protease ATP-binding subunit ClpX 4159590 clpX 4552937 clpX Mycobacterium ulcerans Agy99 ATP-dependent protease ATP-binding subunit ClpX YP_907321.1 4158310 R 362242 CDS YP_907322.1 118618990 4552938 4160226..4161890 1 NC_008611.1 membrane protein; thought to be involved in a transport system across the membrane (perhaps drug transport): responsible for the translocation of the substrate across the membrane.; integral membrane transport protein 4161890 4552938 MUL_3729 Mycobacterium ulcerans Agy99 integral membrane transport protein YP_907322.1 4160226 D 362242 CDS YP_907323.1 118618991 4552939 complement(4161947..4162582) 1 NC_008611.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates; ATP-dependent Clp protease proteolytic subunit 4162582 clpP2 4552939 clpP2 Mycobacterium ulcerans Agy99 ATP-dependent Clp protease proteolytic subunit YP_907323.1 4161947 R 362242 CDS YP_907324.1 118618992 4552940 complement(4162579..4163175) 1 NC_008611.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates; ATP-dependent Clp protease proteolytic subunit 4163175 clpP 4552940 clpP Mycobacterium ulcerans Agy99 ATP-dependent Clp protease proteolytic subunit YP_907324.1 4162579 R 362242 CDS YP_907325.1 118618993 4552941 complement(4163298..4164752) 1 NC_008611.1 Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer; trigger factor 4164752 tig 4552941 tig Mycobacterium ulcerans Agy99 trigger factor YP_907325.1 4163298 R 362242 CDS YP_907326.1 118618994 4552944 4165218..4166318 1 NC_008611.1 cytoplasmic protein; function unknown, lipolytic enzyme involved in cellular metabolism.; esterase/lipase LipP 4166318 lipP 4552944 lipP Mycobacterium ulcerans Agy99 esterase/lipase LipP YP_907326.1 4165218 D 362242 CDS YP_907327.1 118618995 4552945 complement(4166402..4166698) 1 NC_008611.1 secreted protein; hypothetical protein 4166698 4552945 MUL_3736 Mycobacterium ulcerans Agy99 hypothetical protein YP_907327.1 4166402 R 362242 CDS YP_907328.1 118618996 4552946 complement(4166820..4167626) 1 NC_008611.1 cytoplasmic protein; hydrolyses DNA (this enzyme may play a significant role in processes leading to recovery from mutagenesis and/or cell death by alkylating agents); formamidopyrimidine-DNA glycosylase 4167626 4552946 MUL_3737 Mycobacterium ulcerans Agy99 formamidopyrimidine-DNA glycosylase YP_907328.1 4166820 R 362242 CDS YP_907329.1 118618997 4549706 complement(4167635..4168114) 1 NC_008611.1 catalyzes the interconversion of ribose 5-phosphate to ribulose 5-phosphate; enzyme from E. coli shows allose 6-phosphate isomerase activity; ribose-5-phosphate isomerase B 4168114 rpiB 4549706 rpiB Mycobacterium ulcerans Agy99 ribose-5-phosphate isomerase B YP_907329.1 4167635 R 362242 CDS YP_907330.1 118618998 4549709 complement(4170425..4171621) 1 NC_008611.1 PE_PGRS59; membrane protein; N-term PE-PGRS family protein 4171621 4549709 MUL_3741 Mycobacterium ulcerans Agy99 N-term PE-PGRS family protein YP_907330.1 4170425 R 362242 CDS YP_907331.1 118618999 4549710 4171897..4174476 1 NC_008611.1 Also detected in the extracellular matrix by proteomics. Also detected in the membrane fraction by proteomics.; cytoplasmic protein; aminopeptidase with broad substrate specificity to several peptides (could preferentially cleave leucine, arginine and lysine in peptide-bond-containing substrates); aminopeptidase N PepN 4174476 pepN 4549710 pepN Mycobacterium ulcerans Agy99 aminopeptidase N PepN YP_907331.1 4171897 D 362242 CDS YP_907332.1 118619000 4549711 complement(4174569..4175036) 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS. Also detected in the membrane fraction by proteomics (LC-MS/MS); cytoplasmic protein; hypothetical protein 4175036 4549711 MUL_3743 Mycobacterium ulcerans Agy99 hypothetical protein YP_907332.1 4174569 R 362242 CDS YP_907333.1 118619001 4549712 complement(4175023..4175256) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 4175256 4549712 MUL_3744 Mycobacterium ulcerans Agy99 hypothetical protein YP_907333.1 4175023 R 362242 CDS YP_907334.1 118619002 4549713 complement(4175358..4175999) 1 NC_008611.1 cytoplasmic protein; function unknown but contains McrA, restriction endonuclease domain; hypothetical protein 4175999 4549713 MUL_3745 Mycobacterium ulcerans Agy99 hypothetical protein YP_907334.1 4175358 R 362242 CDS YP_907335.1 118619003 4549714 4176153..4176539 1 NC_008611.1 cytoplasmic protein; oxygen carrier, involved in oxygen transport.; globin (oxygen-binding protein) GlbO 4176539 glbO 4549714 glbO Mycobacterium ulcerans Agy99 globin (oxygen-binding protein) GlbO YP_907335.1 4176153 D 362242 CDS YP_907336.1 118619004 4549717 complement(4179915..4181654) 1 NC_008611.1 cytoplasmic protein; involved in cholesterol metabolism [catalytic activity: cholesterol + O(2) = cholest-4-en-3-one + H(2)O(2)]; cholesterol oxidase precursor ChoD_1 4181654 choD_1 4549717 choD_1 Mycobacterium ulcerans Agy99 cholesterol oxidase precursor ChoD_1 YP_907336.1 4179915 R 362242 CDS YP_907337.1 118619005 4549720 4186262..4186966 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; N-term transposase for IS2404 4186966 4549720 MUL_3752 Mycobacterium ulcerans Agy99 N-term transposase for IS2404 YP_907337.1 4186262 D 362242 CDS YP_907338.1 118619006 4549721 4186991..4187308 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; C-term transposase for IS2404 4187308 4549721 MUL_3753 Mycobacterium ulcerans Agy99 C-term transposase for IS2404 YP_907338.1 4186991 D 362242 CDS YP_907339.1 118619007 4549722 complement(4187371..4188033) 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; hypothetical protein 4188033 4549722 MUL_3754 Mycobacterium ulcerans Agy99 hypothetical protein YP_907339.1 4187371 R 362242 CDS YP_907340.1 118619008 4549723 complement(4188030..4188446) 1 NC_008611.1 cytoplasmic protein; function unknown but some identity with thioesterase domains; hypothetical protein 4188446 4549723 MUL_3755 Mycobacterium ulcerans Agy99 hypothetical protein YP_907340.1 4188030 R 362242 CDS YP_907341.1 118619009 4549725 complement(4193462..4195138) 1 NC_008611.1 ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence; putative ABC transporter ATP-binding protein 4195138 4549725 MUL_3757 Mycobacterium ulcerans Agy99 putative ABC transporter ATP-binding protein YP_907341.1 4193462 R 362242 CDS YP_907342.1 118619010 4549726 complement(4195206..4195703) 1 NC_008611.1 cytoplasmic protein; function unknown but may play a role in DNA replication, recombination, and repair; hypothetical protein 4195703 4549726 MUL_3758 Mycobacterium ulcerans Agy99 hypothetical protein YP_907342.1 4195206 R 362242 CDS YP_907343.1 118619011 4549730 complement(4201067..4202992) 1 NC_008611.1 membrane protein; N-terminus: could be generate serine and phosphate from phosphoserine; may catalyze the last step in the biosynthesis of serine from carbohydrates (the reaction mechanism could be proceed via the formation of a phosphoryl-enzyme intermediates) [catalytic activity 1: phosphoserine + H(2)O = serine + phosphate] mid-section: involved in phospholipid biosynthesis (at the second step); converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating acyl moiety at the 2 position [catalytic activity 2: acyl-CoA + 1-acyl-SN- glycerol 3-phosphate = CoA + 1,2-diacyl-SN-glycerol 3- phosphate] c-terminus: contains tola protein domain homology. may serve to anchor this protein in the cm.; bifunctional transmembrane phospholipid biosynthesis enzyme PlsC 4202992 plsC 4549730 plsC Mycobacterium ulcerans Agy99 bifunctional transmembrane phospholipid biosynthesis enzyme PlsC YP_907343.1 4201067 R 362242 CDS YP_907344.1 118619012 4549731 complement(4202989..4204491) 1 NC_008611.1 membrane protein; function unknown but N-term contains a CoA- dependanant acyltransferase domain.; hypothetical protein 4204491 4549731 MUL_3765 Mycobacterium ulcerans Agy99 hypothetical protein YP_907344.1 4202989 R 362242 CDS YP_907345.1 118619013 4549732 complement(4204703..4205956) 1 NC_008611.1 cytoplasmic protein; function unknown, lipolytic enzyme involved in cellular metabolism.; carboxylesterase LipQ 4205956 lipQ 4549732 lipQ Mycobacterium ulcerans Agy99 carboxylesterase LipQ YP_907345.1 4204703 R 362242 CDS YP_907346.1 118619014 4549735 complement(4207301..4207612) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 4207612 4549735 MUL_3769 Mycobacterium ulcerans Agy99 hypothetical protein YP_907346.1 4207301 R 362242 CDS YP_907347.1 118619015 4549736 complement(4207815..4209290) 1 NC_008611.1 catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation; cobyric acid synthase 4209290 cobQ1 4549736 cobQ1 Mycobacterium ulcerans Agy99 cobyric acid synthase YP_907347.1 4207815 R 362242 CDS YP_907348.1 118619016 4549737 4210009..4210419 1 NC_008611.1 secreted protein; hypothetical protein 4210419 4549737 MUL_3771 Mycobacterium ulcerans Agy99 hypothetical protein YP_907348.1 4210009 D 362242 CDS YP_907349.1 118619017 4549738 complement(4210438..4211307) 1 NC_008611.1 Detected in the membrane fraction by proteomics.; membrane protein; involved in mycolic acids modification. catalyzes unusual S-adenosyl-methionine-dependent transformation of a cis-olefin mycolic acid into a secondary alcohol. catalyzes introduction of a hydroxyl group at the distal position on mycolic acid chains to produce the hydroxyl mycolate. mycolic acids represent a major constituent of the mycobacterial cell wall complex. methyl transfer results in formation of a secondary hydroxy group with an adjacent methyl branch; olefinic mycolic acid methyl transferase.; methoxy mycolic acid synthase 5 MmaA5 4211307 mmaA5 4549738 mmaA5 Mycobacterium ulcerans Agy99 methoxy mycolic acid synthase 5 MmaA5 YP_907349.1 4210438 R 362242 CDS YP_907350.1 118619018 4549739 complement(4211626..4212795) 1 NC_008611.1 cytoplasmic protein; involved in energy metabolism. the pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA & CO(2) it contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) & lipoamide dehydrogenase (E3) [catalytic activity: acetyl-CoA + dihydrolipoamide = CoA + S- acetyldihydrolipoamide]; branched-chain alpha-keto acid dehydrogenase subunit E2 4212795 pdhC 4549739 pdhC Mycobacterium ulcerans Agy99 branched-chain alpha-keto acid dehydrogenase subunit E2 YP_907350.1 4211626 R 362242 CDS YP_907351.1 118619019 4549740 complement(4212792..4213838) 1 NC_008611.1 cytoplasmic protein; involved in energy metabolism. the pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA & CO(2) it contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) & lipoamide dehydrogenase (E3) [catalytic activity: acetyl-CoA + dihydrolipoamide = CoA + S- acetyldihydrolipoamide]; pyruvate dehydrogenase E1 component (beta subunit) PdhB 4213838 pdhB 4549740 pdhB Mycobacterium ulcerans Agy99 pyruvate dehydrogenase E1 component (beta subunit) PdhB YP_907351.1 4212792 R 362242 CDS YP_907352.1 118619020 4553465 complement(4213849..4214916) 1 NC_008611.1 cytoplasmic protein; involved in energy metabolism. the pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA & CO(2) it contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) & lipoamide dehydrogenase (E3) [catalytic activity: acetyl-CoA + dihydrolipoamide = CoA + S- acetyldihydrolipoamide]; pyruvate dehydrogenase E1 component (alpha subunit) PdhA 4214916 pdhA 4553465 pdhA Mycobacterium ulcerans Agy99 pyruvate dehydrogenase E1 component (alpha subunit) PdhA YP_907352.1 4213849 R 362242 CDS YP_907353.1 118619021 4553466 complement(4215281..4216102) 1 NC_008611.1 cytoplasmic protein; interconversion of acetate and oxaloacetate from citrate [catalytic activity: citrate = acetate + oxaloacetate]; citrate (pro-3s)-lyase (beta subunit) CitE 4216102 citE 4553466 citE Mycobacterium ulcerans Agy99 citrate (pro-3s)-lyase (beta subunit) CitE YP_907353.1 4215281 R 362242 CDS YP_907354.1 118619022 4553467 complement(4216099..4216605) 1 NC_008611.1 Detected in the cytoplamic fraction by LCMSMS; cytoplasmic protein; function unknown but contains a central MaoC, acyl dehydratase domain; hypothetical protein 4216605 4553467 MUL_3777 Mycobacterium ulcerans Agy99 hypothetical protein YP_907354.1 4216099 R 362242 CDS YP_907355.1 118619023 4553468 complement(4216602..4217768) 1 NC_008611.1 cytoplasmic protein; function unknown, but seems involved in metabolism of small branched-chain fatty acids and macrolide antibiotic production. catalyses the alpha, beta- dehydrogenetion of acyl-CoA esters and transfer electrons to ETF, the electron transfer protein.; acyl-CoA dehydrogenase FadE19 4217768 fadE19 4553468 fadE19 Mycobacterium ulcerans Agy99 acyl-CoA dehydrogenase FadE19 YP_907355.1 4216602 R 362242 CDS YP_907356.1 118619024 4553469 complement(4217775..4219784) 1 NC_008611.1 cytoplasmic protein; this protein carries two functions: biotin carboxyl carrier protein and biotin carboxyltransferase. involved in the first step of long-chain fatty acid synthesis [catalytic activity: ATP + biotin-carboxyl-carrier protein + CO(2) = ADP + phosphate + carboxybiotin-carboxyl-carrier protein]; acetyl-/propionyl-coenzyme a carboxylase alpha chain AccA1 4219784 accA1 4553469 accA1 Mycobacterium ulcerans Agy99 acetyl-/propionyl-coenzyme a carboxylase alpha chain AccA1 YP_907356.1 4217775 R 362242 CDS YP_907357.1 118619025 4553471 complement(4221361..4222008) 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; involved in various degradation and synthesis [catalytic activity: succinyl-CoA + a 3-oxo acid = succinate + a 3-oxo-acyl-CoA]; succinyl-CoA:3-ketoacid-coenzyme a transferase (beta subunit) ScoB 4222008 scoB 4553471 scoB Mycobacterium ulcerans Agy99 succinyl-CoA:3-ketoacid-coenzyme a transferase (beta subunit) ScoB YP_907357.1 4221361 R 362242 CDS YP_907358.1 118619026 4553472 complement(4222164..4222910) 1 NC_008611.1 cytoplasmic protein; involved in fatty acid degradation/synthesis [catalytic activity: succinyl-CoA + a 3-oxo acid = succinate + a 3-oxo-acyl-CoA]; succinyl-CoA:3-ketoacid-coenzyme a transferase (alpha subunit) ScoA 4222910 scoA 4553472 scoA Mycobacterium ulcerans Agy99 succinyl-CoA:3-ketoacid-coenzyme a transferase (alpha subunit) ScoA YP_907358.1 4222164 R 362242 CDS YP_907359.1 118619027 4553474 complement(4223284..4224330) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 4224330 4553474 MUL_3784 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_907359.1 4223284 R 362242 CDS YP_907360.1 118619028 4553475 4226155..4226790 1 NC_008611.1 cytoplasmic protein; involved in transcriptional mechanism.; putative regulatory protein 4226790 4553475 MUL_3785 Mycobacterium ulcerans Agy99 putative regulatory protein YP_907360.1 4226155 D 362242 CDS YP_907361.1 118619029 4553476 4227021..4227812 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; proline rich membrane protein 4227812 4553476 MUL_3786 Mycobacterium ulcerans Agy99 proline rich membrane protein YP_907361.1 4227021 D 362242 CDS YP_907362.1 118619030 4553477 complement(4227809..4229137) 1 NC_008611.1 membrane protein; integral membrane leucine and alanine rich protein 4229137 4553477 MUL_3787 Mycobacterium ulcerans Agy99 integral membrane leucine and alanine rich protein YP_907362.1 4227809 R 362242 CDS YP_907363.1 118619031 4553478 4229233..4230039 1 NC_008611.1 cytoplasmic protein; function unknown, possibly involved in cellular metabolism.; short-chain type dehydrogenase/reductase 4230039 4553478 MUL_3788 Mycobacterium ulcerans Agy99 short-chain type dehydrogenase/reductase YP_907363.1 4229233 D 362242 CDS YP_907364.1 118619032 4554333 4231764..4232411 1 NC_008611.1 3'-5' exoribonuclease specific for small oligoribonuclotides; oligoribonuclease 4232411 orn 4554333 orn Mycobacterium ulcerans Agy99 oligoribonuclease YP_907364.1 4231764 D 362242 CDS YP_907365.1 118619033 4554335 complement(4232597..4233298) 1 NC_008611.1 membrane protein; hypothetical protein 4233298 4554335 MUL_3792 Mycobacterium ulcerans Agy99 hypothetical protein YP_907365.1 4232597 R 362242 CDS YP_907366.1 118619034 4554336 complement(4233262..4234050) 1 NC_008611.1 cytoplasmic protein; involved in transcriptional mechanism.; putative regulatory protein 4234050 4554336 MUL_3793 Mycobacterium ulcerans Agy99 putative regulatory protein YP_907366.1 4233262 R 362242 CDS YP_907367.1 118619035 4554337 4234348..4235217 1 NC_008611.1 membrane protein; function unknown, YrbE family protein that is similar to Ttg2B-like ABC-type transport system involved in resistance to organic solvents, permease component.; YrbE family protein, YrbE5A 4235217 yrbE5A 4554337 yrbE5A Mycobacterium ulcerans Agy99 YrbE family protein, YrbE5A YP_907367.1 4234348 D 362242 CDS YP_907368.1 118619036 4554339 4236107..4237639 1 NC_008611.1 membrane protein; this family of proteins contains the Mce (mycobacterial cell entry) proteins from mycobacterium tuberculosis. the archetype (Rv0169), was isolated as being necessary for colonisation of, and survival within, the macrophage. this family contains proteins of unknown function from other bacteria.; Mce protein, Mce5A 4237639 mce5A 4554339 mce5A Mycobacterium ulcerans Agy99 Mce protein, Mce5A YP_907368.1 4236107 D 362242 CDS YP_907369.1 118619037 4554340 4237636..4238691 1 NC_008611.1 membrane protein; this family of proteins contains the Mce (mycobacterial cell entry) proteins from mycobacterium tuberculosis. the archetype (Rv0169), was isolated as being necessary for colonisation of, and survival within, the macrophage. this family contains proteins of unknown function from other bacteria.; Mce family protein, Mce5B 4238691 mce5B 4554340 mce5B Mycobacterium ulcerans Agy99 Mce family protein, Mce5B YP_907369.1 4237636 D 362242 CDS YP_907370.1 118619038 4554341 4238684..4239739 1 NC_008611.1 membrane protein; this family of proteins contains the Mce (mycobacterial cell entry) proteins from mycobacterium tuberculosis. the archetype (Rv0169), was isolated as being necessary for colonisation of, and survival within, the macrophage. this family contains proteins of unknown function from other bacteria.; Mce family protein, Mce5C 4239739 mce5C 4554341 mce5C Mycobacterium ulcerans Agy99 Mce family protein, Mce5C YP_907370.1 4238684 D 362242 CDS YP_907371.1 118619039 4554343 4240851..4242056 1 NC_008611.1 membrane protein; this family of proteins contains the Mce (mycobacterial cell entry) proteins from mycobacterium tuberculosis. the archetype (Rv0169), was isolated as being necessary for colonisation of, and survival within, the macrophage. this family contains proteins of unknown function from other bacteria.; Mce family protein, Mce5E 4242056 mce5E 4554343 mce5E Mycobacterium ulcerans Agy99 Mce family protein, Mce5E YP_907371.1 4240851 D 362242 CDS YP_907372.1 118619040 4554344 4242053..4243303 1 NC_008611.1 membrane protein; this family of proteins contains the Mce (mycobacterial cell entry) proteins from mycobacterium tuberculosis. the archetype (Rv0169), was isolated as being necessary for colonisation of, and survival within, the macrophage. this family contains proteins of unknown function from other bacteria.; Mce family protein Mce5F 4243303 mce5F 4554344 mce5F Mycobacterium ulcerans Agy99 Mce family protein Mce5F YP_907372.1 4242053 D 362242 CDS YP_907373.1 118619041 4554345 4243331..4244023 1 NC_008611.1 cytoplasmic protein; hypothetical protein 4244023 4554345 MUL_3802 Mycobacterium ulcerans Agy99 hypothetical protein YP_907373.1 4243331 D 362242 CDS YP_907374.1 118619042 4554346 4244042..4244821 1 NC_008611.1 secreted protein; hypothetical protein 4244821 4554346 MUL_3803 Mycobacterium ulcerans Agy99 hypothetical protein YP_907374.1 4244042 D 362242 CDS YP_907375.1 118619043 4554347 complement(4244823..4246025) 1 NC_008611.1 secreted protein; lipoprotein LppS 4246025 lppS 4554347 lppS Mycobacterium ulcerans Agy99 lipoprotein LppS YP_907375.1 4244823 R 362242 CDS YP_907376.1 118619044 4554348 4246026..4246163 1 NC_008611.1 secreted protein; hypothetical protein 4246163 4554348 MUL_3805 Mycobacterium ulcerans Agy99 hypothetical protein YP_907376.1 4246026 D 362242 CDS YP_907377.1 118619045 4554252 4246971..4247855 1 NC_008611.1 cytoplasmic protein; function unknown but domain identity suggests PlsC, phosphate acyltransferase. these enzymes function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2- acylglycerolphosphoethanolamine acyltransferase activities.; hypothetical protein 4247855 4554252 MUL_3808 Mycobacterium ulcerans Agy99 hypothetical protein YP_907377.1 4246971 D 362242 CDS YP_907378.1 118619046 4554253 4248048..4249787 1 NC_008611.1 membrane protein; hypothetical protein 4249787 4554253 MUL_3809 Mycobacterium ulcerans Agy99 hypothetical protein YP_907378.1 4248048 D 362242 CDS YP_907379.1 118619047 4554254 complement(4249899..4250126) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; hypothetical protein 4250126 4554254 MUL_3810 Mycobacterium ulcerans Agy99 hypothetical protein YP_907379.1 4249899 R 362242 CDS YP_907380.1 118619048 4554255 4250234..4250707 1 NC_008611.1 Detected in the cytoplasmic and membrane fractiond and in the secreted proteins by 2D-LC-MS/MS.; cytoplasmic protein; putative antioxidant protein.; bacterioferritin comigratory protein Bcp 4250707 bcp 4554255 bcp Mycobacterium ulcerans Agy99 bacterioferritin comigratory protein Bcp YP_907380.1 4250234 D 362242 CDS YP_907381.1 118619049 4554256 complement(4250708..4252033) 1 NC_008611.1 cytoplasmic protein; deacetylates acetylornithine and hydrolyses N- acetylmethionine.; hypothetical protein 4252033 argE 4554256 argE Mycobacterium ulcerans Agy99 hypothetical protein YP_907381.1 4250708 R 362242 CDS YP_907382.1 118619050 4554258 4253214..4253870 1 NC_008611.1 cytoplasmic protein; regulator part of the two component regulatory system.; two component transcriptional regulatory protein 4253870 4554258 MUL_3814 Mycobacterium ulcerans Agy99 two component transcriptional regulatory protein YP_907382.1 4253214 D 362242 CDS YP_907383.1 118619051 4554261 complement(4255894..4256286) 1 NC_008611.1 Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids; 4'-phosphopantetheinyl transferase 4256286 acpS 4554261 acpS Mycobacterium ulcerans Agy99 4'-phosphopantetheinyl transferase YP_907383.1 4255894 R 362242 CDS YP_907384.1 118619052 4554262 complement(4256315..4265533) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS) Also detected in the cytoplasm.; membrane protein; involved in lipid metabolism. fatty acid synthase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH; fatty acid synthase Fas 4265533 fas 4554262 fas Mycobacterium ulcerans Agy99 fatty acid synthase Fas YP_907384.1 4256315 R 362242 CDS YP_907385.1 118619053 4554263 complement(4266041..4266763) 1 NC_008611.1 secreted protein; hypothetical protein 4266763 4554263 MUL_3819 Mycobacterium ulcerans Agy99 hypothetical protein YP_907385.1 4266041 R 362242 CDS YP_907386.1 118619054 4554264 4267005..4268147 1 NC_008611.1 may act to bind either a ubiquinol or plastoquinol anion, transferring an electron to the 2Fe-2S cluster, then releasing the electron to a cytochrome C or cytochrome F haem iron.; ring-hydroxylating dioxygenase, large terminal subunit 4268147 4554264 MUL_3820 Mycobacterium ulcerans Agy99 ring-hydroxylating dioxygenase, large terminal subunit YP_907386.1 4267005 D 362242 CDS YP_907387.1 118619055 4554266 complement(4269736..4270182) 1 NC_008611.1 cytoplasmic protein; function unknown role in lipid metabolism; contains a thioesterase/thiol ester dehydratase-isomerase superfamily domain; acyl dehydratase MaoC 4270182 maoC 4554266 maoC Mycobacterium ulcerans Agy99 acyl dehydratase MaoC YP_907387.1 4269736 R 362242 CDS YP_907388.1 118619056 4554267 complement(4270179..4270697) 1 NC_008611.1 cytoplasmic protein; function unknown but like d/s ORF it contains a thioesterase/thiol ester dehydrase-isomerase superfmaily domain.; hypothetical protein 4270697 4554267 MUL_3823 Mycobacterium ulcerans Agy99 hypothetical protein YP_907388.1 4270179 R 362242 CDS YP_907389.1 118619057 4554268 complement(4270721..4271164) 1 NC_008611.1 Also detected in the extracellular matrix by proteomics.; cytoplasmic protein; hypothetical protein 4271164 4554268 MUL_3824 Mycobacterium ulcerans Agy99 hypothetical protein YP_907389.1 4270721 R 362242 CDS YP_907390.1 118619058 4554145 4273115..4274791 1 NC_008611.1 membrane protein; function unknown, possibly involved in transport of drug across the membrane. contains AraJ, arabinose efflux permease domain identity.; hypothetical protein 4274791 4554145 MUL_3826 Mycobacterium ulcerans Agy99 hypothetical protein YP_907390.1 4273115 D 362242 CDS YP_907391.1 118619059 4554146 complement(4275071..4276117) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 4276117 4554146 MUL_3827 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_907391.1 4275071 R 362242 CDS YP_907392.1 118619060 4554147 complement(4276335..4276601) 1 NC_008611.1 cytoplasmic protein; function unknown but acetyl-CoA synthetase-like superfamily domain detected.; hypothetical protein 4276601 4554147 MUL_3828 Mycobacterium ulcerans Agy99 hypothetical protein YP_907392.1 4276335 R 362242 CDS YP_907393.1 118619061 4554148 complement(4276666..4277793) 1 NC_008611.1 cytoplasmic protein; function unknown, probably involved in cellular metabolism. contains domain identity to phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases.; oxidoreductase 4277793 4554148 MUL_3829 Mycobacterium ulcerans Agy99 oxidoreductase YP_907393.1 4276666 R 362242 CDS YP_907394.1 118619062 4554149 complement(4278379..4278570) 1 NC_008611.1 cytoplasmic protein; ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.; ferredoxin FdxD_1 4278570 fdxD_1 4554149 fdxD_1 Mycobacterium ulcerans Agy99 ferredoxin FdxD_1 YP_907394.1 4278379 R 362242 CDS YP_907395.1 118619063 4554151 4281091..4281912 1 NC_008611.1 cytoplasmic protein; involved in transcriptional mechanism.; FadR family transcriptional regulator 4281912 4554151 MUL_3832 Mycobacterium ulcerans Agy99 FadR family transcriptional regulator YP_907395.1 4281091 D 362242 CDS YP_907396.1 118619064 4554152 4282283..4283617 1 NC_008611.1 cytoplasmic protein; required for the transposition of the insertion element IS2606.; transposase for IS2606 4283617 4554152 MUL_3833 Mycobacterium ulcerans Agy99 transposase for IS2606 YP_907396.1 4282283 D 362242 CDS YP_907397.1 118619065 4554153 4284052..4285098 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 4285098 4554153 MUL_3834 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_907397.1 4284052 D 362242 CDS YP_907398.1 118619066 4554156 complement(4288220..4289266) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 4289266 4554156 MUL_3837 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_907398.1 4288220 R 362242 CDS YP_907399.1 118619067 4554128 complement(4291244..4292092) 1 NC_008611.1 cytoplasmic protein; coenzyme F420-dependent oxidoreductase 4292092 4554128 MUL_3839 Mycobacterium ulcerans Agy99 coenzyme F420-dependent oxidoreductase YP_907399.1 4291244 R 362242 CDS YP_907400.1 118619068 4554129 4292182..4293231 1 NC_008611.1 cytoplasmic protein; function unknown, but involved in lipid degradation.; acyl-CoA dehydrogenase 4293231 4554129 MUL_3840 Mycobacterium ulcerans Agy99 acyl-CoA dehydrogenase YP_907400.1 4292182 D 362242 CDS YP_907401.1 118619069 4554131 4294340..4295497 1 NC_008611.1 cytoplasmic protein; function unknown, but supposed involvement in lipid degradation.; acyl-CoA dehydrogenase FadE17_2 4295497 fadE17_2 4554131 fadE17_2 Mycobacterium ulcerans Agy99 acyl-CoA dehydrogenase FadE17_2 YP_907401.1 4294340 D 362242 CDS YP_907402.1 118619070 4554132 4295494..4296429 1 NC_008611.1 cytoplasmic protein; function unknown role in lipid metabolism; acyl-CoA dehydrogenase 4296429 4554132 MUL_3843 Mycobacterium ulcerans Agy99 acyl-CoA dehydrogenase YP_907402.1 4295494 D 362242 CDS YP_907403.1 118619071 4554133 4296426..4297919 1 NC_008611.1 cytoplasmic protein; function unknown, but involved in lipid degradation.; fatty-acid-CoA ligase 4297919 4554133 MUL_3844 Mycobacterium ulcerans Agy99 fatty-acid-CoA ligase YP_907403.1 4296426 D 362242 CDS YP_907404.1 118619072 4554135 4300217..4300585 1 NC_008611.1 secreted protein; hypothetical protein 4300585 4554135 MUL_3846 Mycobacterium ulcerans Agy99 hypothetical protein YP_907404.1 4300217 D 362242 CDS YP_907405.1 118619073 4554136 4300805..4301281 1 NC_008611.1 membrane protein; function unknown but contains a ricin-type beta- trefoil domain.; hypothetical protein 4301281 4554136 MUL_3847 Mycobacterium ulcerans Agy99 hypothetical protein YP_907405.1 4300805 D 362242 CDS YP_907406.1 118619074 4554137 4301448..4302467 1 NC_008611.1 cytoplasmic protein; function unknown. possibly involved in transcriptional mechanism.; putative transcriptional regulatory protein 4302467 4554137 MUL_3848 Mycobacterium ulcerans Agy99 putative transcriptional regulatory protein YP_907406.1 4301448 D 362242 CDS YP_907407.1 118619075 4554138 4302539..4303744 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS; cytoplasmic protein; metal-dependent hydrolase 4303744 4554138 MUL_3849 Mycobacterium ulcerans Agy99 metal-dependent hydrolase YP_907407.1 4302539 D 362242 CDS YP_907408.1 118619076 4554141 4307110..4309143 1 NC_008611.1 cytoplasmic protein; may be involved in regulation of SigG; regulator of sigma subunit, anti-anti-sigma factor RsbU 4309143 rsbU 4554141 rsbU Mycobacterium ulcerans Agy99 regulator of sigma subunit, anti-anti-sigma factor RsbU YP_907408.1 4307110 D 362242 CDS YP_907409.1 118619077 4554142 complement(4309156..4310391) 1 NC_008611.1 cytoplasmic protein; function unknown, but involved in lipid degradation.; acyl-CoA dehydrogenase 4310391 4554142 MUL_3854 Mycobacterium ulcerans Agy99 acyl-CoA dehydrogenase YP_907409.1 4309156 R 362242 CDS YP_907410.1 118619078 4553893 4313093..4313902 1 NC_008611.1 hypothetical protein 4313902 4553893 MUL_3858 Mycobacterium ulcerans Agy99 hypothetical protein YP_907410.1 4313093 D 362242 CDS YP_907411.1 118619079 4553894 4313899..4314561 1 NC_008611.1 cytoplasmic protein; hypothetical protein 4314561 4553894 MUL_3859 Mycobacterium ulcerans Agy99 hypothetical protein YP_907411.1 4313899 D 362242 CDS YP_907412.1 118619080 4553895 4314847..4316073 1 NC_008611.1 cytoplasmic protein; cytochromes P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.; cytochrome P450 187A4 Cyp187A4 4316073 cyp187A4 4553895 cyp187A4 Mycobacterium ulcerans Agy99 cytochrome P450 187A4 Cyp187A4 YP_907412.1 4314847 D 362242 CDS YP_907413.1 118619081 4553896 4316070..4317224 1 NC_008611.1 cytoplasmic protein; thought to catalyze the reversible oxidation of ethanol to acetaldehyde with the concomitant reduction of NAD. probably acts on primary or secondary alcohols or hemiacetals [catalytic activity: an alcohol + NAD+ = an aldehyde or ketone + NADH]; zinc-containing alcohol dehydrogenase NAD dependent AdhB_1 4317224 adhB_1 4553896 adhB_1 Mycobacterium ulcerans Agy99 zinc-containing alcohol dehydrogenase NAD dependent AdhB_1 YP_907413.1 4316070 D 362242 CDS YP_907414.1 118619082 4553897 complement(4317167..4318081) 1 NC_008611.1 cytoplasmic protein; function unknown, probably involved in cellular metabolism.; short chain dehydrogenase 4318081 4553897 MUL_3862 Mycobacterium ulcerans Agy99 short chain dehydrogenase YP_907414.1 4317167 R 362242 CDS YP_907415.1 118619083 4553898 complement(4318186..4319418) 1 NC_008611.1 cytoplasmic protein; cytochromes P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.; cytochrome P450 108B4 Cyp108B4 4319418 cyp108B4 4553898 cyp108B4 Mycobacterium ulcerans Agy99 cytochrome P450 108B4 Cyp108B4 YP_907415.1 4318186 R 362242 CDS YP_907416.1 118619084 4553899 4319609..4321105 1 NC_008611.1 cytoplasmic protein; key enzyme in the catabolic pathway of odd-chain fatty acids, isoleucine, threonine, methionine, and valine [catalytic activity: ATP + propionyl-CoA + CO(2) + H(2)O = ADP + orthophosphate + methylmalonyl-CoA]; propionyl-CoA carboxylase beta chain 4 AccD4_2 4321105 accD4_2 4553899 accD4_2 Mycobacterium ulcerans Agy99 propionyl-CoA carboxylase beta chain 4 AccD4_2 YP_907416.1 4319609 D 362242 CDS YP_907417.1 118619085 4553900 complement(4321095..4322645) 1 NC_008611.1 May not be functional. C-term of the dehydrogenase section missing 40 aa. may be site of DNA deletion, resulting in a translation fusion with a d/s ORF . C-term contains full length of an uncharacterized homolog of a gamma-carboxymuconolactone decarboxylase subunit; membrane protein; dehydrogenase/decarboxylase protein 4322645 4553900 MUL_3865 Mycobacterium ulcerans Agy99 dehydrogenase/decarboxylase protein YP_907417.1 4321095 R 362242 CDS YP_907418.1 118619086 4553901 complement(4322829..4323875) 1 NC_008611.1 cytoplasmic protein; function unknown, probably involved in cellular metabolism.; oxidoreductase 4323875 4553901 MUL_3866 Mycobacterium ulcerans Agy99 oxidoreductase YP_907418.1 4322829 R 362242 CDS YP_907419.1 118619087 4553902 complement(4323872..4324255) 1 NC_008611.1 cytoplasmic protein; function unknown but contains a Ntf2-like superfmaily domain; hypothetical protein 4324255 4553902 MUL_3867 Mycobacterium ulcerans Agy99 hypothetical protein YP_907419.1 4323872 R 362242 CDS YP_907420.1 118619088 4553903 complement(4324252..4324488) 1 NC_008611.1 secreted protein; hypothetical protein 4324488 4553903 MUL_3868 Mycobacterium ulcerans Agy99 hypothetical protein YP_907420.1 4324252 R 362242 CDS YP_907421.1 118619089 4553904 4324619..4325236 1 NC_008611.1 cytoplasmic protein; function unknown but contains thioesterase/thiol ester dehydrase-isomerase superfmaily domain; hypothetical protein 4325236 4553904 MUL_3869 Mycobacterium ulcerans Agy99 hypothetical protein YP_907421.1 4324619 D 362242 CDS YP_907422.1 118619090 4553905 4325324..4326967 1 NC_008611.1 activates fatty acids by binding to coenzyme A; in Mycobacterium may be involved in virulence; acyl-CoA synthetase 4326967 fadD19_2 4553905 fadD19_2 Mycobacterium ulcerans Agy99 acyl-CoA synthetase YP_907422.1 4325324 D 362242 CDS YP_907423.1 118619091 4553906 complement(4327067..4328113) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 4328113 4553906 MUL_3871 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_907423.1 4327067 R 362242 CDS YP_907424.1 118619092 4553907 4328422..4329636 1 NC_008611.1 cytoplasmic protein; cytochromes P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.; cytochrome P450 187A5 Cyp187A5 4329636 cyp187A5 4553907 cyp187A5 Mycobacterium ulcerans Agy99 cytochrome P450 187A5 Cyp187A5 YP_907424.1 4328422 D 362242 CDS YP_907425.1 118619093 4553908 4329769..4330860 1 NC_008611.1 cytoplasmic protein; dehydratase 4330860 4553908 MUL_3873 Mycobacterium ulcerans Agy99 dehydratase YP_907425.1 4329769 D 362242 CDS YP_907426.1 118619094 4553909 complement(4330882..4332063) 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; function unknown, but involved in lipid degradation.; acyl-CoA dehydrogenase 4332063 4553909 MUL_3874 Mycobacterium ulcerans Agy99 acyl-CoA dehydrogenase YP_907426.1 4330882 R 362242 CDS YP_907427.1 118619095 4553911 complement(4333139..4333975) 1 NC_008611.1 cytoplasmic protein; metal-dependent hydrolase 4333975 4553911 MUL_3876 Mycobacterium ulcerans Agy99 metal-dependent hydrolase YP_907427.1 4333139 R 362242 CDS YP_907428.1 118619096 4553785 complement(4335626..4336831) 1 NC_008611.1 cytoplasmic protein; metal-dependent hydrolase 4336831 4553785 MUL_3878 Mycobacterium ulcerans Agy99 metal-dependent hydrolase YP_907428.1 4335626 R 362242 CDS YP_907429.1 118619097 4553786 complement(4336860..4337702) 1 NC_008611.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 4337702 echA12_1 4553786 echA12_1 Mycobacterium ulcerans Agy99 enoyl-CoA hydratase YP_907429.1 4336860 R 362242 CDS YP_907430.1 118619098 4553788 complement(4338801..4339445) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 4339445 4553788 MUL_3882 Mycobacterium ulcerans Agy99 hypothetical protein YP_907430.1 4338801 R 362242 CDS YP_907431.1 118619099 4553789 4339666..4339995 1 NC_008611.1 cytoplasmic protein; hypothetical protein 4339995 4553789 MUL_3883 Mycobacterium ulcerans Agy99 hypothetical protein YP_907431.1 4339666 D 362242 CDS YP_907432.1 118619100 4553790 4340399..4341202 1 NC_008611.1 cytoplasmic protein; involved in transcriptional mechanism; transcriptional regulatory protein 4341202 4553790 MUL_3884 Mycobacterium ulcerans Agy99 transcriptional regulatory protein YP_907432.1 4340399 D 362242 CDS YP_907433.1 118619101 4553791 complement(4341215..4342111) 1 NC_008611.1 cytoplasmic protein; oxidizes fatty acids using specific components [catalytic activity: (3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H(2)O]; enoyl-CoA hydratase, EchA4_2 4342111 echA4_2 4553791 echA4_2 Mycobacterium ulcerans Agy99 enoyl-CoA hydratase, EchA4_2 YP_907433.1 4341215 R 362242 CDS YP_907434.1 118619102 4553792 complement(4342108..4342782) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 4342782 4553792 MUL_3886 Mycobacterium ulcerans Agy99 hypothetical protein YP_907434.1 4342108 R 362242 CDS YP_907435.1 118619103 4553793 4342902..4343720 1 NC_008611.1 cytoplasmic protein; oxidizes fatty acids using specific components (by similarity) [catalytic activity: (3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H(2)O]; enoyl-CoA hydratase EchA10_1 4343720 echA10_1 4553793 echA10_1 Mycobacterium ulcerans Agy99 enoyl-CoA hydratase EchA10_1 YP_907435.1 4342902 D 362242 CDS YP_907436.1 118619104 4553794 4343717..4344535 1 NC_008611.1 cytoplasmic protein; oxidizes fatty acids using specific components [catalytic activity: (3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H(2)O]; enoyl-CoA hydratase EchA11_1 4344535 echA11_1 4553794 echA11_1 Mycobacterium ulcerans Agy99 enoyl-CoA hydratase EchA11_1 YP_907436.1 4343717 D 362242 CDS YP_907437.1 118619105 4553795 4344526..4345341 1 NC_008611.1 cytoplasmic protein; oxidizes fatty acids using specific components [catalytic activity: (3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H(2)O]; enoyl-CoA hydratase EchA16_1 4345341 echA16_1 4553795 echA16_1 Mycobacterium ulcerans Agy99 enoyl-CoA hydratase EchA16_1 YP_907437.1 4344526 D 362242 CDS YP_907438.1 118619106 4553796 4345341..4346822 1 NC_008611.1 cytoplasmic protein; function unknown, but supposed involvement in lipid degradation.; long-chain fatty-acid CoA ligase 4346822 4553796 MUL_3890 Mycobacterium ulcerans Agy99 long-chain fatty-acid CoA ligase YP_907438.1 4345341 D 362242 CDS YP_907439.1 118619107 4553799 complement(4350245..4350610) 1 NC_008611.1 secreted protein; hypothetical protein 4350610 4553799 MUL_3893 Mycobacterium ulcerans Agy99 hypothetical protein YP_907439.1 4350245 R 362242 CDS YP_907440.1 118619108 4553800 complement(4350811..4351524) 1 NC_008611.1 cytoplasmic protein; possibly involved in transcriptional mechanism.; GntR family transcriptional regulator 4351524 4553800 MUL_3894 Mycobacterium ulcerans Agy99 GntR family transcriptional regulator YP_907440.1 4350811 R 362242 CDS YP_907441.1 118619109 4553801 complement(4351538..4352731) 1 NC_008611.1 cytoplasmic protein; function unknown, but involved in lipid degradation.; acyl-CoA dehydrogenase 4352731 4553801 MUL_3895 Mycobacterium ulcerans Agy99 acyl-CoA dehydrogenase YP_907441.1 4351538 R 362242 CDS YP_907442.1 118619110 4553802 complement(4352728..4353957) 1 NC_008611.1 function unknown, but supposed involvement in lipid degradation.; acyl-CoA transferase/carnitine dehydratase 4353957 4553802 MUL_3896 Mycobacterium ulcerans Agy99 acyl-CoA transferase/carnitine dehydratase YP_907442.1 4352728 R 362242 CDS YP_907443.1 118619111 4553714 complement(4355179..4355931) 1 NC_008611.1 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-(acyl-carrier-protein) reductase 4355931 fabG 4553714 fabG Mycobacterium ulcerans Agy99 3-ketoacyl-(acyl-carrier-protein) reductase YP_907443.1 4355179 R 362242 CDS YP_907444.1 118619112 4553717 complement(4357441..4359180) 1 NC_008611.1 membrane protein; thought to be involved in active transport of drugs across the membrane (export): multidrugs resistance by an export mechanism. responsible for energy coupling to the transport system and for the translocation of the substrate across the membrane.; transmembrane ATP-binding protein ABC transporter 4359180 4553717 MUL_3901 Mycobacterium ulcerans Agy99 transmembrane ATP-binding protein ABC transporter YP_907444.1 4357441 R 362242 CDS YP_907445.1 118619113 4553718 complement(4359177..4361801) 1 NC_008611.1 membrane protein; thought to be involved in active transport of drugs across the membrane (export): multidrugs resistance by an export mechanism. responsible for energy coupling to the transport system and for the translocation of the substrate across the membrane.; transmembrane ATP-binding protein ABC transporter 4361801 4553718 MUL_3902 Mycobacterium ulcerans Agy99 transmembrane ATP-binding protein ABC transporter YP_907445.1 4359177 R 362242 CDS YP_907446.1 118619114 4553720 4362538..4362930 1 NC_008611.1 membrane protein; lipoprotein LprD 4362930 lprD 4553720 lprD Mycobacterium ulcerans Agy99 lipoprotein LprD YP_907446.1 4362538 D 362242 CDS YP_907447.1 118619115 4553721 4362927..4363289 1 NC_008611.1 membrane protein; hypothetical protein 4363289 4553721 MUL_3905 Mycobacterium ulcerans Agy99 hypothetical protein YP_907447.1 4362927 D 362242 CDS YP_907448.1 118619116 4553722 complement(4363309..4363923) 1 NC_008611.1 HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine; putative deoxyribonucleotide triphosphate pyrophosphatase 4363923 4553722 MUL_3906 Mycobacterium ulcerans Agy99 putative deoxyribonucleotide triphosphate pyrophosphatase YP_907448.1 4363309 R 362242 CDS YP_907449.1 118619117 4553723 complement(4364076..4364618) 1 NC_008611.1 membrane protein; hypothetical protein 4364618 4553723 MUL_3907 Mycobacterium ulcerans Agy99 hypothetical protein YP_907449.1 4364076 R 362242 CDS YP_907450.1 118619118 4553724 complement(4364899..4365678) 1 NC_008611.1 RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs; ribonuclease PH 4365678 rph 4553724 rph Mycobacterium ulcerans Agy99 ribonuclease PH YP_907450.1 4364899 R 362242 CDS YP_907451.1 118619119 4553725 complement(4365780..4366553) 1 NC_008611.1 cytoplasmic protein; metal-dependent hydrolase 4366553 4553725 MUL_3909 Mycobacterium ulcerans Agy99 metal-dependent hydrolase YP_907451.1 4365780 R 362242 CDS YP_907452.1 118619120 4553726 complement(4366553..4366732) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 4366732 4553726 MUL_3910 Mycobacterium ulcerans Agy99 hypothetical protein YP_907452.1 4366553 R 362242 CDS YP_907453.1 118619121 4553727 4366931..4367662 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; hypothetical protein 4367662 4553727 MUL_3911 Mycobacterium ulcerans Agy99 hypothetical protein YP_907453.1 4366931 D 362242 CDS YP_907454.1 118619122 4553728 complement(4367929..4370256) 1 NC_008611.1 cytoplasmic protein; involved in energy metabolism; contributes to acetyl-CoA production as part of pyruvate dehydrogenase complex [catalytic activity: pyruvate + lipoamide = S- acetyl-dihydro-lipoamide + CO(2)]; pyruvate dehydrogenase E1 component AceE_1 4370256 aceE_1 4553728 aceE_1 Mycobacterium ulcerans Agy99 pyruvate dehydrogenase E1 component AceE_1 YP_907454.1 4367929 R 362242 CDS YP_907455.1 118619123 4553729 4370365..4370883 1 NC_008611.1 cytoplasmic protein; involved in transcriptional mechanism.; Lrp/AsnC family transcriptional regulator 4370883 4553729 MUL_3913 Mycobacterium ulcerans Agy99 Lrp/AsnC family transcriptional regulator YP_907455.1 4370365 D 362242 CDS YP_907456.1 118619124 4553730 4371250..4371750 1 NC_008611.1 secreted protein; hypothetical protein 4371750 4553730 MUL_3914 Mycobacterium ulcerans Agy99 hypothetical protein YP_907456.1 4371250 D 362242 CDS YP_907457.1 118619125 4553585 4372513..4373280 1 NC_008611.1 membrane protein; integral membrane protein YrbE3A_1 4373280 yrbE3A_1 4553585 yrbE3A_1 Mycobacterium ulcerans Agy99 integral membrane protein YrbE3A_1 YP_907457.1 4372513 D 362242 CDS YP_907458.1 118619126 4553586 4373277..4374131 1 NC_008611.1 membrane protein; integral membrane protein YrbE3B_1 4374131 yrbE3B_1 4553586 yrbE3B_1 Mycobacterium ulcerans Agy99 integral membrane protein YrbE3B_1 YP_907458.1 4373277 D 362242 CDS YP_907459.1 118619127 4553587 4374136..4375596 1 NC_008611.1 membrane protein; function unknown, but thought to be involved in host cell invasion.; MCE-family protein Mce3A_1 4375596 mce3A_1 4553587 mce3A_1 Mycobacterium ulcerans Agy99 MCE-family protein Mce3A_1 YP_907459.1 4374136 D 362242 CDS YP_907460.1 118619128 4553588 4375676..4376707 1 NC_008611.1 membrane protein; function unknown, but thought to be involved in host cell invasion.; MCE-family protein Mce3B_1 4376707 mce3B_1 4553588 mce3B_1 Mycobacterium ulcerans Agy99 MCE-family protein Mce3B_1 YP_907460.1 4375676 D 362242 CDS YP_907461.1 118619129 4553589 4376704..4378020 1 NC_008611.1 membrane protein; function unknown, but thought to be involved in host cell invasion.; MCE-family protein, Mce3C_1 4378020 mce3C_1 4553589 mce3C_1 Mycobacterium ulcerans Agy99 MCE-family protein, Mce3C_1 YP_907461.1 4376704 D 362242 CDS YP_907462.1 118619130 4553590 4378017..4379348 1 NC_008611.1 membrane protein; function unknown, but thought to be involved in host cell invasion.; MCE-family protein Mce3D_1 4379348 mce3D_1 4553590 mce3D_1 Mycobacterium ulcerans Agy99 MCE-family protein Mce3D_1 YP_907462.1 4378017 D 362242 CDS YP_907463.1 118619131 4553591 4379348..4380490 1 NC_008611.1 membrane protein; function unknown, but thought to be involved in host cell invasion.; MCE family lipoprotein LprM 4380490 lprM_1 4553591 lprM_1 Mycobacterium ulcerans Agy99 MCE family lipoprotein LprM YP_907463.1 4379348 D 362242 CDS YP_907464.1 118619132 4553592 4380492..4381949 1 NC_008611.1 membrane protein; function unknown, but thought involved in host cell invasion.; MCE-family protein Mce3F_1 4381949 mce3F_1 4553592 mce3F_1 Mycobacterium ulcerans Agy99 MCE-family protein Mce3F_1 YP_907464.1 4380492 D 362242 CDS YP_907465.1 118619133 4553593 4381946..4382647 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; Mce associated membrane protein 4382647 4553593 MUL_3924 Mycobacterium ulcerans Agy99 Mce associated membrane protein YP_907465.1 4381946 D 362242 CDS YP_907466.1 118619134 4553594 complement(4382690..4383505) 1 NC_008611.1 converts L-glutamate to D-glutamate, a component of peptidoglycan; glutamate racemase 4383505 murI 4553594 murI Mycobacterium ulcerans Agy99 glutamate racemase YP_907466.1 4382690 R 362242 CDS YP_907467.1 118619135 4553596 complement(4384351..4384623) 1 NC_008611.1 secreted protein; antigen Cfp10A 4384623 cfp10A 4553596 cfp10A Mycobacterium ulcerans Agy99 antigen Cfp10A YP_907467.1 4384351 R 362242 CDS YP_907468.1 118619136 4553597 complement(4384645..4385058) 1 NC_008611.1 cytoplasmic protein; function unknown but domain identity suggests this CDS encodes a metal-dependent protease of the Pad1/Jab1 superfamily.; hypothetical protein 4385058 4553597 MUL_3928 Mycobacterium ulcerans Agy99 hypothetical protein YP_907468.1 4384645 R 362242 CDS YP_907469.1 118619137 4553598 complement(4385060..4386148) 1 NC_008611.1 membrane protein; function unknown, probable role in amino acid hydrolysis; L-aminopeptidase/D-esterase DmpA 4386148 dmpA 4553598 dmpA Mycobacterium ulcerans Agy99 L-aminopeptidase/D-esterase DmpA YP_907469.1 4385060 R 362242 CDS YP_907470.1 118619138 4553599 complement(4386145..4386732) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 4386732 4553599 MUL_3930 Mycobacterium ulcerans Agy99 hypothetical protein YP_907470.1 4386145 R 362242 CDS YP_907471.1 118619139 4553600 complement(4386757..4386969) 1 NC_008611.1 cytoplasmic protein; function unknown but contains a ClpS domain suggesting a function related to ATP-dependent protein degradation.; hypothetical protein 4386969 4553600 MUL_3931 Mycobacterium ulcerans Agy99 hypothetical protein YP_907471.1 4386757 R 362242 CDS YP_907472.1 118619140 4553601 4387128..4388444 1 NC_008611.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-diphosphate and nicotinate from nicotinate D-ribonucleotide and diphosphate; nicotinate phosphoribosyltransferase 4388444 pncB 4553601 pncB Mycobacterium ulcerans Agy99 nicotinate phosphoribosyltransferase YP_907472.1 4387128 D 362242 CDS YP_907473.1 118619141 4553602 4388480..4390501 1 NC_008611.1 cytoplasmic protein; probable helicase involved in DNA repair and perhaps also replication.; ATP-dependent helicase DinG 4390501 dinG 4553602 dinG Mycobacterium ulcerans Agy99 ATP-dependent helicase DinG YP_907473.1 4388480 D 362242 CDS YP_907474.1 118619142 4553603 complement(4390498..4393089) 1 NC_008611.1 cytoplasmic protein; catalytic activity : {(1,4)-alpha-D-glucosyl}(N) + phosphate = {(1,4)-alpha-D-glucosyl}(N-1) + alpha-D- glucose 1-phosphate.; glycogen phosphorylase GlgP 4393089 glgP 4553603 glgP Mycobacterium ulcerans Agy99 glycogen phosphorylase GlgP YP_907474.1 4390498 R 362242 CDS YP_907475.1 118619143 4553604 4393279..4395366 1 NC_008611.1 also detected in the membrane fraction by proteomics (LC-MS/MS); cytoplasmic protein; function unknown, may be involved in polysaccharide degradation.; glycosidase 4395366 4553604 MUL_3935 Mycobacterium ulcerans Agy99 glycosidase YP_907475.1 4393279 D 362242 CDS YP_907476.1 118619144 4552503 4395373..4397568 1 NC_008611.1 catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain; glycogen branching enzyme 4397568 glgB 4552503 glgB Mycobacterium ulcerans Agy99 glycogen branching enzyme YP_907476.1 4395373 D 362242 CDS YP_907477.1 118619145 4552504 complement(4397635..4398549) 1 NC_008611.1 Also detected in the extracellular matrix and secreted fraction by proteomics.; extracellular matrix protein; thioredoxin participates in various redox reactions through the reversible oxidation of its active center dithiol, to a disulfide, & catalyzes dithiol-disulfide exchange reactions; thioredoxin 4398549 4552504 MUL_3937 Mycobacterium ulcerans Agy99 thioredoxin YP_907477.1 4397635 R 362242 CDS YP_907478.1 118619146 4552505 complement(4398727..4399908) 1 NC_008611.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; in Rhizobia and Ralstonia is involved in PHB biosynthesis; acetyl-CoA acetyltransferase 4399908 fadA4 4552505 fadA4 Mycobacterium ulcerans Agy99 acetyl-CoA acetyltransferase YP_907478.1 4398727 R 362242 CDS YP_907479.1 118619147 4552506 4399991..4400458 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; glyoxalase I (lactoylglutathione lyase) catalyzes the first step of the glyoxal pathway.; glyoxalase, GloA_1 4400458 gloA_1 4552506 gloA_1 Mycobacterium ulcerans Agy99 glyoxalase, GloA_1 YP_907479.1 4399991 D 362242 CDS YP_907480.1 118619148 4552507 complement(4400771..4401451) 1 NC_008611.1 cytoplasmic protein; function unknown but contains a predicted nuclease domain of the RecB family; hypothetical protein 4401451 4552507 MUL_3940 Mycobacterium ulcerans Agy99 hypothetical protein YP_907480.1 4400771 R 362242 CDS YP_907481.1 118619149 4552508 complement(4401542..4402876) 1 NC_008611.1 cytoplasmic protein; required for the transposition of the insertion element IS2606.; transposase for IS2606 4402876 4552508 MUL_3941 Mycobacterium ulcerans Agy99 transposase for IS2606 YP_907481.1 4401542 R 362242 CDS YP_907482.1 118619150 4552510 4404115..4405161 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 4405161 4552510 MUL_3943 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_907482.1 4404115 D 362242 CDS YP_907483.1 118619151 4552511 4406071..4407690 1 NC_008611.1 membrane protein; thought to play a role in regulation of cellular metabolism by catalysing the synthesis of a second messenger, camp [catalytic activity: ATP = 3',5'-cyclic AMP + pyrophosphate]; adenylate cyclase 4407690 4552511 MUL_3944 Mycobacterium ulcerans Agy99 adenylate cyclase YP_907483.1 4406071 D 362242 CDS YP_907484.1 118619152 4552512 4407773..4409260 1 NC_008611.1 cytoplasmic protein; involved in damage reversal and in base excision repair. the methylated Ada protein acts as a positive regulator of its own synthesis, as well as that of other proteins. the transcription-activating function of the Ada protein resides in its N-terminus. repair of alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. this is a suicide reaction: the enzyme is irreversibly inactivated. can also repair O-4- methylthymine [catalytic activity: DNA (containing 6-O- methylguanine) + [protein]-L-cysteine = DNA (without 6-O- methylguanine) + protein S-methyl-L-cysteine]; Ada regulatory protein AlkA 4409260 alkA 4552512 alkA Mycobacterium ulcerans Agy99 Ada regulatory protein AlkA YP_907484.1 4407773 D 362242 CDS YP_907485.1 118619153 4552513 4409257..4409775 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS. Also detected in the membrane fraction by proteomics (2D-LC-MS/MS); cytoplasmic protein; repair of alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. this is a suicide reaction: the enzyme is irreversibly inactivated [catalytic activity : DNA (containing 6-O-methylguanine) + [protein]-L-cysteine = DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine]; methylated-DNA--protein-cysteine methyltransferase Ogt 4409775 ogt 4552513 ogt Mycobacterium ulcerans Agy99 methylated-DNA--protein-cysteine methyltransferase Ogt YP_907485.1 4409257 D 362242 CDS YP_907486.1 118619154 4552517 complement(4415229..4416482) 1 NC_008611.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active; UDP-N-acetylglucosamine 1-carboxyvinyltransferase 4416482 murA 4552517 murA Mycobacterium ulcerans Agy99 UDP-N-acetylglucosamine 1-carboxyvinyltransferase YP_907486.1 4415229 R 362242 CDS YP_907487.1 118619155 4552587 4416553..4417146 1 NC_008611.1 Detected in the cytoplamic fraction by LC-MS/MS. Also detected in the membrane fraction by proteomics (2D- LC-MS/MS); membrane protein; these proteins convert inactive cobalamins to AdoCbl for 1,2-propanediol degradation.; cobalamin adenosyltransferase 4417146 4552587 MUL_3951 Mycobacterium ulcerans Agy99 cobalamin adenosyltransferase YP_907487.1 4416553 D 362242 CDS YP_907488.1 118619156 4552588 complement(4417237..4417680) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 4417680 4552588 MUL_3952 Mycobacterium ulcerans Agy99 hypothetical protein YP_907488.1 4417237 R 362242 CDS YP_907489.1 118619157 4552589 complement(4417688..4418068) 1 NC_008611.1 part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane; F0F1 ATP synthase subunit epsilon 4418068 atpC 4552589 atpC Mycobacterium ulcerans Agy99 F0F1 ATP synthase subunit epsilon YP_907489.1 4417688 R 362242 CDS YP_907490.1 118619158 4552590 complement(4418105..4419556) 1 NC_008611.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit; F0F1 ATP synthase subunit beta 4419556 atpD 4552590 atpD Mycobacterium ulcerans Agy99 F0F1 ATP synthase subunit beta YP_907490.1 4418105 R 362242 CDS YP_907491.1 118619159 4552591 complement(4419585..4420499) 1 NC_008611.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit; F0F1 ATP synthase subunit gamma 4420499 atpG 4552591 atpG Mycobacterium ulcerans Agy99 F0F1 ATP synthase subunit gamma YP_907491.1 4419585 R 362242 CDS YP_907492.1 118619160 4552592 complement(4420518..4422167) 1 NC_008611.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit; F0F1 ATP synthase subunit alpha 4422167 atpA 4552592 atpA Mycobacterium ulcerans Agy99 F0F1 ATP synthase subunit alpha YP_907492.1 4420518 R 362242 CDS YP_907493.1 118619161 4552593 complement(4422229..4423566) 1 NC_008611.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex; F0F1 ATP synthase subunit delta 4423566 atpH 4552593 atpH Mycobacterium ulcerans Agy99 F0F1 ATP synthase subunit delta YP_907493.1 4422229 R 362242 CDS YP_907494.1 118619162 4552594 complement(4423573..4424085) 1 NC_008611.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel.; F0F1 ATP synthase subunit B 4424085 atpF 4552594 atpF Mycobacterium ulcerans Agy99 F0F1 ATP synthase subunit B YP_907494.1 4423573 R 362242 CDS YP_907495.1 118619163 4552595 complement(4424127..4424372) 1 NC_008611.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0; F0F1 ATP synthase subunit C 4424372 atpE 4552595 atpE Mycobacterium ulcerans Agy99 F0F1 ATP synthase subunit C YP_907495.1 4424127 R 362242 CDS YP_907496.1 118619164 4552596 complement(4424463..4425215) 1 NC_008611.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0; F0F1 ATP synthase subunit A 4425215 atpB 4552596 atpB Mycobacterium ulcerans Agy99 F0F1 ATP synthase subunit A YP_907496.1 4424463 R 362242 CDS YP_907497.1 118619165 4552597 complement(4425184..4425708) 1 NC_008611.1 membrane protein; hypothetical protein 4425708 4552597 MUL_3961 Mycobacterium ulcerans Agy99 hypothetical protein YP_907497.1 4425184 R 362242 CDS YP_907498.1 118619166 4552598 complement(4425958..4427139) 1 NC_008611.1 membrane protein; catalysis of the first step of the lipid cycle reactions in the biosynthesis of cell wall peptidoglycan.; undecapaprenyl-phosphate alpha-N- acetylglucosaminyltransferase Rfe 4427139 rfe 4552598 rfe Mycobacterium ulcerans Agy99 undecapaprenyl-phosphate alpha-N- acetylglucosaminyltransferase Rfe YP_907498.1 4425958 R 362242 CDS YP_907499.1 118619167 4552599 complement(4427218..4427868) 1 NC_008611.1 function unknown but contains YrdC domain. this domain has been shown to preferentially bind to dsRNA.; hypothetical protein 4427868 4552599 MUL_3963 Mycobacterium ulcerans Agy99 hypothetical protein YP_907499.1 4427218 R 362242 CDS YP_907500.1 118619168 4552600 complement(4427921..4428769) 1 NC_008611.1 cytoplasmic protein; function unknown but may have S-adenosyl-methionine- dependent methyltransferase activity.; modification methylase HemK 4428769 hemK 4552600 hemK Mycobacterium ulcerans Agy99 modification methylase HemK YP_907500.1 4427921 R 362242 CDS YP_907501.1 118619169 4552601 complement(4428766..4429839) 1 NC_008611.1 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2; peptide chain release factor 1 4429839 prfA 4552601 prfA Mycobacterium ulcerans Agy99 peptide chain release factor 1 YP_907501.1 4428766 R 362242 CDS YP_907502.1 118619170 4552602 complement(4429927..4430172) 1 NC_008611.1 RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 4430172 rpmE 4552602 rpmE Mycobacterium ulcerans Agy99 50S ribosomal protein L31 YP_907502.1 4429927 R 362242 CDS YP_907503.1 118619171 4552603 complement(4430364..4432229) 1 NC_008611.1 An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes; transcription termination factor Rho 4432229 rho 4552603 rho Mycobacterium ulcerans Agy99 transcription termination factor Rho YP_907503.1 4430364 R 362242 CDS YP_907504.1 118619172 4552604 complement(4432496..4433440) 1 NC_008611.1 catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate; homoserine kinase 4433440 thrB 4552604 thrB Mycobacterium ulcerans Agy99 homoserine kinase YP_907504.1 4432496 R 362242 CDS YP_907505.1 118619173 4552605 complement(4433496..4434578) 1 NC_008611.1 catalyzes the formation of L-threonine from O-phospho-L-homoserine; threonine synthase 4434578 thrC 4552605 thrC Mycobacterium ulcerans Agy99 threonine synthase YP_907505.1 4433496 R 362242 CDS YP_907506.1 118619174 4551394 complement(4434575..4435900) 1 NC_008611.1 catalyzes the formation of L-aspartate 4-semialdehyde from L-homoserine; homoserine dehydrogenase 4435900 thrA 4551394 thrA Mycobacterium ulcerans Agy99 homoserine dehydrogenase YP_907506.1 4434575 R 362242 CDS YP_907507.1 118619175 4551395 complement(4435904..4437322) 1 NC_008611.1 cytoplasmic protein; involved in biosynthesis of lysine (last step) [catalytic activity : meso-2,6-diaminoheptanedioate = L- lysine + CO(2)]; diaminopimelate decarboxylase LysA 4437322 lysA 4551395 lysA Mycobacterium ulcerans Agy99 diaminopimelate decarboxylase LysA YP_907507.1 4435904 R 362242 CDS YP_907508.1 118619176 4551396 complement(4437319..4438971) 1 NC_008611.1 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase; arginyl-tRNA synthetase 4438971 argS 4551396 argS Mycobacterium ulcerans Agy99 arginyl-tRNA synthetase YP_907508.1 4437319 R 362242 CDS YP_907509.1 118619177 4551398 4439665..4439940 1 NC_008611.1 cytoplasmic protein; hypothetical protein 4439940 4551398 MUL_3974 Mycobacterium ulcerans Agy99 hypothetical protein YP_907509.1 4439665 D 362242 CDS YP_907510.1 118619178 4551399 complement(4440081..4440611) 1 NC_008611.1 membrane protein; PE-PGRS family protein 4440611 4551399 MUL_3975 Mycobacterium ulcerans Agy99 PE-PGRS family protein YP_907510.1 4440081 R 362242 CDS YP_907511.1 118619179 4551400 4441115..4443784 1 NC_008611.1 cytoplasmic protein; this family of dehydrogenases act on aldehyde substrates. members use NADP as a cofactor.; bifunctional acetaldehyde-CoA/alcohol dehydrogenase 4443784 4551400 MUL_3976 Mycobacterium ulcerans Agy99 bifunctional acetaldehyde-CoA/alcohol dehydrogenase YP_907511.1 4441115 D 362242 CDS YP_907512.1 118619180 4551401 complement(4443750..4444127) 1 NC_008611.1 cytoplasmic protein; pyridoxamine 5'-phosphate oxidase is a FMN flavoprotein involved in the de novo synthesis of pyridoxine (vitamin B6) and pyridoxal phosphate.; pyridoxamine 5'-phosphate oxidase-related protein 4444127 4551401 MUL_3977 Mycobacterium ulcerans Agy99 pyridoxamine 5'-phosphate oxidase-related protein YP_907512.1 4443750 R 362242 CDS YP_907513.1 118619181 4551402 complement(4444223..4444594) 1 NC_008611.1 cytoplasmic protein; function unknown but contains YCII-related protein domain; hypothetical protein 4444594 4551402 MUL_3978 Mycobacterium ulcerans Agy99 hypothetical protein YP_907513.1 4444223 R 362242 CDS YP_907514.1 118619182 4551403 complement(4444575..4445447) 1 NC_008611.1 catalyzes the cleavage of carbon-halogen bonds in aliphatic compounds forming a primary alcohol and a halide; haloalkane dehalogenase 4445447 dhaA 4551403 dhaA Mycobacterium ulcerans Agy99 haloalkane dehalogenase YP_907514.1 4444575 R 362242 CDS YP_907515.1 118619183 4551404 complement(4445498..4447288) 1 NC_008611.1 cytoplasmic protein; cleaves xaa-pro-releasing N-terminal dipeptides.; peptidase S15 4447288 4551404 MUL_3980 Mycobacterium ulcerans Agy99 peptidase S15 YP_907515.1 4445498 R 362242 CDS YP_907516.1 118619184 4551405 4447429..4448076 1 NC_008611.1 cytoplasmic protein; function unknown but belongs to the TetR family of bacterial transcriptional regulatory proteins.; putative regulatory protein 4448076 4551405 MUL_3981 Mycobacterium ulcerans Agy99 putative regulatory protein YP_907516.1 4447429 D 362242 CDS YP_907517.1 118619185 4551406 complement(4448086..4448598) 1 NC_008611.1 membrane protein; PE-PGRS family protein 4448598 4551406 MUL_3982 Mycobacterium ulcerans Agy99 PE-PGRS family protein YP_907517.1 4448086 R 362242 CDS YP_907518.1 118619186 4551407 complement(4448729..4449634) 1 NC_008611.1 cytoplasmic protein; function unknown, belongs to the LysR family of transcriptional regulators; putative regulatory protein 4449634 4551407 MUL_3983 Mycobacterium ulcerans Agy99 putative regulatory protein YP_907518.1 4448729 R 362242 CDS YP_907519.1 118619187 4551408 4449725..4451053 1 NC_008611.1 membrane protein; function unknown role in transport. belongs to the DMT superfamily.; membrane permease 4451053 4551408 MUL_3984 Mycobacterium ulcerans Agy99 membrane permease YP_907519.1 4449725 D 362242 CDS YP_907520.1 118619188 4551409 4451034..4451585 1 NC_008611.1 membrane protein; hypothetical protein 4451585 4551409 MUL_3985 Mycobacterium ulcerans Agy99 hypothetical protein YP_907520.1 4451034 D 362242 CDS YP_907521.1 118619189 4551410 4451780..4453366 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; thought to play a role in regulation of cellular metabolism by catalysing the synthesis of a second messenger, camp [catalytic activity: ATP = 3',5'-cyclic AMP + pyrophosphate]; adenylate cyclase 4453366 4551410 MUL_3986 Mycobacterium ulcerans Agy99 adenylate cyclase YP_907521.1 4451780 D 362242 CDS YP_907522.1 118619190 4551411 4453532..4453873 1 NC_008611.1 secreted protein; hypothetical protein 4453873 4551411 MUL_3987 Mycobacterium ulcerans Agy99 hypothetical protein YP_907522.1 4453532 D 362242 CDS YP_907523.1 118619191 4550730 complement(4456652..4457851) 1 NC_008611.1 membrane protein; PE-PGRS family protein 4457851 4550730 MUL_3990 Mycobacterium ulcerans Agy99 PE-PGRS family protein YP_907523.1 4456652 R 362242 CDS YP_907524.1 118619192 4550731 complement(4457949..4458821) 1 NC_008611.1 cytoplasmic protein; function unknown, probably involved in cellular metabolism.; flavin-dependent oxidoreductase 4458821 4550731 MUL_3991 Mycobacterium ulcerans Agy99 flavin-dependent oxidoreductase YP_907524.1 4457949 R 362242 CDS YP_907525.1 118619193 4550732 4458867..4459289 1 NC_008611.1 cytoplasmic protein; catalyzes the first step of the glyoxal pathway; glyoxalase, GloA_2 4459289 gloA_2 4550732 gloA_2 Mycobacterium ulcerans Agy99 glyoxalase, GloA_2 YP_907525.1 4458867 D 362242 CDS YP_907526.1 118619194 4550733 4459382..4459771 1 NC_008611.1 cytoplasmic protein; function unknown but contains glyoxalase/bleomycin resistance protein/Dihydroxybiphenyl dioxygenase superfamily domain.; hypothetical protein 4459771 4550733 MUL_3993 Mycobacterium ulcerans Agy99 hypothetical protein YP_907526.1 4459382 D 362242 CDS YP_907527.1 118619195 4550734 complement(4459768..4460253) 1 NC_008611.1 cytoplasmic protein; putative transcriptional regulatory protein 4460253 4550734 MUL_3994 Mycobacterium ulcerans Agy99 putative transcriptional regulatory protein YP_907527.1 4459768 R 362242 CDS YP_907528.1 118619196 4550735 complement(4460347..4462197) 1 NC_008611.1 in Rhizobium meliloti this protein is involved in the synthesis of nodulation factors that are active on the roots of alfalfa; catalyzes formation of activated sulfate intermediate; converts ATP and sulfate to diphosphate and adenylylsulfate and then ATP and adenylyl sulfate to ADP and 3'-phosphoadenylyl sulfate; the activated intermediate is transferred to the nodulation factors by NodH; may interact with NodP and NodQ; similar to the CysD and CysN proteins from EScherichia coli involved in cysteine biosynthesis; bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein 4462197 cysN 4550735 cysN Mycobacterium ulcerans Agy99 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein YP_907528.1 4460347 R 362242 CDS YP_907529.1 118619197 4550736 complement(4462197..4463129) 1 NC_008611.1 with CysN catalyzes the formation of adenylylsulfate from sulfate and ATP; sulfate adenylyltransferase subunit 2 4463129 cysD 4550736 cysD Mycobacterium ulcerans Agy99 sulfate adenylyltransferase subunit 2 YP_907529.1 4462197 R 362242 CDS YP_907530.1 118619198 4550737 4463317..4463751 1 NC_008611.1 cytoplasmic protein; function unknown, contains a thioesterase superfamily domain; hypothetical protein 4463751 4550737 MUL_3997 Mycobacterium ulcerans Agy99 hypothetical protein YP_907530.1 4463317 D 362242 CDS YP_907531.1 118619199 4550738 complement(4463759..4464250) 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS. Also detected in the extracellular matrix and membrane fraction by proteomics.; membrane protein; domain identity to carbonic anhydrases. these are zinc metalloenzymes which catalyze the reversible hydration of carbon dioxide.; carbonic anhydrase 4464250 4550738 MUL_3998 Mycobacterium ulcerans Agy99 carbonic anhydrase YP_907531.1 4463759 R 362242 CDS YP_907532.1 118619200 4550739 4464573..4465550 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; involved in active transport of oligopeptide across the membrane (import) responsible for the translocation of the substrate across the membrane.; oligopeptide-transport integral membrane protein ABC transporter OppB 4465550 oppB 4550739 oppB Mycobacterium ulcerans Agy99 oligopeptide-transport integral membrane protein ABC transporter OppB YP_907532.1 4464573 D 362242 CDS YP_907533.1 118619201 4550740 4465547..4466440 1 NC_008611.1 membrane protein; involved in active transport of oligopeptide across the membrane (import) responsible for the translocation of the substrate across the membrane.; oligopeptide-transport integral membrane protein ABC transporter OppC 4466440 oppC 4550740 oppC Mycobacterium ulcerans Agy99 oligopeptide-transport integral membrane protein ABC transporter OppC YP_907533.1 4465547 D 362242 CDS YP_907534.1 118619202 4550741 4466437..4468275 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; involved in active transport of oligopeptide across the membrane (import) responsible for energy coupling to the transport system.; oligopeptide-transport ATP-binding protein ABC transporter OppD 4468275 oppD 4550741 oppD Mycobacterium ulcerans Agy99 oligopeptide-transport ATP-binding protein ABC transporter OppD YP_907534.1 4466437 D 362242 CDS YP_907535.1 118619203 4550742 4468376..4470013 1 NC_008611.1 Also detected in the cytoplasm.; membrane protein; involved in active transport of oligopeptide across the membrane (import) this protein is a component of the oligopeptide permease, a binding protein-dependent transport system; it binds peptides up to five amino acids long with high affinity.; periplasmic oligopeptide-binding lipoprotein OppA 4470013 oppA 4550742 oppA Mycobacterium ulcerans Agy99 periplasmic oligopeptide-binding lipoprotein OppA YP_907535.1 4468376 D 362242 CDS YP_907536.1 118619204 4550744 complement(4471338..4472927) 1 NC_008611.1 cytoplasmic protein; function unknown, probably involved in cellular metabolism, probably electron-transfer-linked.; dehydrogenase fad flavoprotein GMC oxidoreductase 4472927 4550744 MUL_4004 Mycobacterium ulcerans Agy99 dehydrogenase fad flavoprotein GMC oxidoreductase YP_907536.1 4471338 R 362242 CDS YP_907537.1 118619205 4550745 complement(4472977..4475607) 1 NC_008611.1 Detected in the cytoplamic fraction by LCMSMS; cytoplasmic protein; function unknown, contains P-loop containing nucleoside triphosphate hydrolase superfamily domain; hydrolase 4475607 4550745 MUL_4005 Mycobacterium ulcerans Agy99 hydrolase YP_907537.1 4472977 R 362242 CDS YP_907538.1 118619206 4550746 complement(4475604..4476755) 1 NC_008611.1 cytoplasmic protein; function unknown: possible role in DNA replication, recombination, and repair.; DNA repair exonuclease SbcD 4476755 sbcD 4550746 sbcD Mycobacterium ulcerans Agy99 DNA repair exonuclease SbcD YP_907538.1 4475604 R 362242 CDS YP_907539.1 118619207 4549954 4477041..4477544 1 NC_008611.1 cytoplasmic protein; function unknown, possible role in signal transduction; phosphohistidine phosphatase SixA 4477544 sixA 4549954 sixA Mycobacterium ulcerans Agy99 phosphohistidine phosphatase SixA YP_907539.1 4477041 D 362242 CDS YP_907540.1 118619208 4549955 complement(4477604..4478182) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; lipoprotein LprC 4478182 lprC 4549955 lprC Mycobacterium ulcerans Agy99 lipoprotein LprC YP_907540.1 4477604 R 362242 CDS YP_907541.1 118619209 4549956 complement(4478179..4478736) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; lipoprotein LprB 4478736 lprB 4549956 lprB Mycobacterium ulcerans Agy99 lipoprotein LprB YP_907541.1 4478179 R 362242 CDS YP_907542.1 118619210 4549957 4478884..4480623 1 NC_008611.1 membrane protein; thought to be involved in active transport of drugs across the membrane (export): multidrugs resistance by an export mechanism. responsible for energy coupling to the transport system and for the translocation of the substrate across the membrane.; transmembrane ATP-binding protein ABC transporter 4480623 4549957 MUL_4010 Mycobacterium ulcerans Agy99 transmembrane ATP-binding protein ABC transporter YP_907542.1 4478884 D 362242 CDS YP_907543.1 118619211 4549958 4480620..4482542 1 NC_008611.1 membrane protein; thought to be involved in active transport of drugs across the membrane (export): multidrugs resistance by an export mechanism. responsible for energy coupling to the transport system and for the translocation of the substrate across the membrane.; transmembrane ATP-binding protein ABC transporter 4482542 4549958 MUL_4011 Mycobacterium ulcerans Agy99 transmembrane ATP-binding protein ABC transporter YP_907543.1 4480620 D 362242 CDS YP_907544.1 118619212 4549960 4485121..4485453 1 NC_008611.1 secreted protein; hypothetical protein 4485453 4549960 MUL_4013 Mycobacterium ulcerans Agy99 hypothetical protein YP_907544.1 4485121 D 362242 CDS YP_907545.1 118619213 4549961 4485685..4486017 1 NC_008611.1 secreted protein; hypothetical protein 4486017 4549961 MUL_4014 Mycobacterium ulcerans Agy99 hypothetical protein YP_907545.1 4485685 D 362242 CDS YP_907546.1 118619214 4549962 4486257..4486997 1 NC_008611.1 membrane protein; lipoprotein LprA 4486997 lprA 4549962 lprA Mycobacterium ulcerans Agy99 lipoprotein LprA YP_907546.1 4486257 D 362242 CDS YP_907547.1 118619215 4549963 4487114..4487449 1 NC_008611.1 secreted protein; hypothetical protein 4487449 4549963 MUL_4016 Mycobacterium ulcerans Agy99 hypothetical protein YP_907547.1 4487114 D 362242 CDS YP_907548.1 118619216 4549964 4487593..4488303 1 NC_008611.1 secreted protein; hypothetical protein 4488303 4549964 MUL_4017 Mycobacterium ulcerans Agy99 hypothetical protein YP_907548.1 4487593 D 362242 CDS YP_907549.1 118619217 4549965 4488640..4489800 1 NC_008611.1 cytoplasmic protein; involved in transcriptional mechanism. thought to regulate the biosynthesis of the mycobacterial cell wall arabinan and resistance to ethambutol (Emb; dextro-2,2'- (ethylenediimino)-di-1-butanol), regulating EmbA and EmbB.; transcriptional regulatory protein EmbR 4489800 embR 4549965 embR Mycobacterium ulcerans Agy99 transcriptional regulatory protein EmbR YP_907549.1 4488640 D 362242 CDS YP_907550.1 118619218 4549967 complement(4492344..4493246) 1 NC_008611.1 cytoplasmic protein; LuxR family transcriptional regulator 4493246 4549967 MUL_4020 Mycobacterium ulcerans Agy99 LuxR family transcriptional regulator YP_907550.1 4492344 R 362242 CDS YP_907551.1 118619219 4549968 4493352..4494200 1 NC_008611.1 Detected in the cytoplasmic fraction by LC-MS/MS. Also detected in the extracellular matrix and membrane fraction by proteomics.; cytoplasmic protein; interconversion of acetate and oxaloacetate from citrate [catalytic activity: citrate = acetate + oxaloacetate]; citrate (pro-3s)-lyase (beta subunit) CitE_1 4494200 citE_1 4549968 citE_1 Mycobacterium ulcerans Agy99 citrate (pro-3s)-lyase (beta subunit) CitE_1 YP_907551.1 4493352 D 362242 CDS YP_907552.1 118619220 4549969 4494188..4494715 1 NC_008611.1 Detected in the cytoplasmic fraction by LC-MS/MS. Also detected in the membrane fraction by proteomics (2D- LC-MS/MS); cytoplasmic protein; dehydratase 4494715 4549969 MUL_4022 Mycobacterium ulcerans Agy99 dehydratase YP_907552.1 4494188 D 362242 CDS YP_907553.1 118619221 4549970 4494715..4496052 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS) Also detected in the cytoplamic fraction by LCMSMS; membrane protein; could be implicated in several pathways involving acetyl-CoA. E.G. acetyl-CoA hydrolase from yeast catalyses the formation of acetate from acetyl-CoA, CoA transferase (CAT1) produces succinyl-CoA, and acetate-CoA transferase utilizes acyl-CoA and acetate to form acetyl-CoA.; acetyl-CoA hydrolase/transferase 4496052 4549970 MUL_4023 Mycobacterium ulcerans Agy99 acetyl-CoA hydrolase/transferase YP_907553.1 4494715 D 362242 CDS YP_907554.1 118619222 4549971 4496070..4497245 1 NC_008611.1 Detected in the cytoplasmic and membrane fractionc by proteomics.; cytoplasmic protein; function unknown, but involved in lipid degradation.; acyl-CoA dehydrogenase FadE3 4497245 fadE3 4549971 fadE3 Mycobacterium ulcerans Agy99 acyl-CoA dehydrogenase FadE3 YP_907554.1 4496070 D 362242 CDS YP_907555.1 118619223 4549972 complement(4497277..4498185) 1 NC_008611.1 membrane protein; hydrolyses glycerophosphodiesters such as glycerophosphocholine, glycerophosphoethanolamine, glycerophosphoglycerol, and bis(glycerophosphoglycerol); glycerolphosphodiesterase GdpD 4498185 gdpD 4549972 gdpD Mycobacterium ulcerans Agy99 glycerolphosphodiesterase GdpD YP_907555.1 4497277 R 362242 CDS YP_907556.1 118619224 4550081 complement(4498378..4498803) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 4498803 4550081 MUL_4026 Mycobacterium ulcerans Agy99 hypothetical protein YP_907556.1 4498378 R 362242 CDS YP_907557.1 118619225 4550082 4498875..4499507 1 NC_008611.1 secreted protein; hypothetical protein 4499507 4550082 MUL_4027 Mycobacterium ulcerans Agy99 hypothetical protein YP_907557.1 4498875 D 362242 CDS YP_907558.1 118619226 4550083 complement(4499576..4499995) 1 NC_008611.1 cytoplasmic protein; glyoxalase I (lactoylglutathione lyase) catalyzes the first step of the glyoxal pathway.; glyoxalase, GloA_3 4499995 gloA_3 4550083 gloA_3 Mycobacterium ulcerans Agy99 glyoxalase, GloA_3 YP_907558.1 4499576 R 362242 CDS YP_907559.1 118619227 4550084 complement(4500714..4502048) 1 NC_008611.1 cytoplasmic protein; required for the transposition of the insertion element IS2606.; transposase for IS2606 4502048 4550084 MUL_4029 Mycobacterium ulcerans Agy99 transposase for IS2606 YP_907559.1 4500714 R 362242 CDS YP_907560.1 118619228 4550085 4502436..4503140 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; N-term transposase for IS2404 4503140 4550085 MUL_4030 Mycobacterium ulcerans Agy99 N-term transposase for IS2404 YP_907560.1 4502436 D 362242 CDS YP_907561.1 118619229 4550086 4503165..4503482 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; C-term transposase for IS2404 4503482 4550086 MUL_4031 Mycobacterium ulcerans Agy99 C-term transposase for IS2404 YP_907561.1 4503165 D 362242 CDS YP_907562.1 118619230 4550089 complement(4504820..4505509) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; hypothetical protein 4505509 4550089 MUL_4034 Mycobacterium ulcerans Agy99 hypothetical protein YP_907562.1 4504820 R 362242 CDS YP_907563.1 118619231 4550090 complement(4505592..4506947) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; possibly involved in the uptake of malate and other dicarboxylates by a proton symport mechanism. in E. coli, this protein has been implicated in resistance to tellurite.; C4-dicarboxylate transporter/malic acid transport protein 4506947 4550090 MUL_4035 Mycobacterium ulcerans Agy99 C4-dicarboxylate transporter/malic acid transport protein YP_907563.1 4505592 R 362242 CDS YP_907564.1 118619232 4550091 4506947..4507189 1 NC_008611.1 secreted protein; hypothetical protein 4507189 4550091 MUL_4036 Mycobacterium ulcerans Agy99 hypothetical protein YP_907564.1 4506947 D 362242 CDS YP_907565.1 118619233 4550093 complement(4508056..4508760) 1 NC_008611.1 membrane protein; hypothetical protein 4508760 4550093 MUL_4038 Mycobacterium ulcerans Agy99 hypothetical protein YP_907565.1 4508056 R 362242 CDS YP_907566.1 118619234 4550094 4509084..4510559 1 NC_008611.1 membrane protein; function unknown but contains a cell envelope- related transcriptional attenuator domain. CpsA is a domain of unknown function that is found in the predicted extracellular domain of a number of putative membrane- bound proteins. may play a role in regulation of transcription.; membrane protein CpsA 4510559 cpsA 4550094 cpsA Mycobacterium ulcerans Agy99 membrane protein CpsA YP_907566.1 4509084 D 362242 CDS YP_907567.1 118619235 4550095 complement(4510566..4511357) 1 NC_008611.1 cytoplasmic protein; function unknown, probably involved in cellular metabolism; short-chain type dehydrogenase/reductase 4511357 4550095 MUL_4041 Mycobacterium ulcerans Agy99 short-chain type dehydrogenase/reductase YP_907567.1 4510566 R 362242 CDS YP_907568.1 118619236 4550096 complement(4511361..4512194) 1 NC_008611.1 cytoplasmic protein; function unknown, supposed to be involved in cellular metabolism.; short chain dehydrogenase 4512194 4550096 MUL_4042 Mycobacterium ulcerans Agy99 short chain dehydrogenase YP_907568.1 4511361 R 362242 CDS YP_907569.1 118619237 4550097 complement(4512286..4512528) 1 NC_008611.1 cytoplasmic protein; probable role in the biosynthesis of the product from U/S PKS gene, carrying its acyl intermediates.; acyl carrier protein 4512528 4550097 MUL_4043 Mycobacterium ulcerans Agy99 acyl carrier protein YP_907569.1 4512286 R 362242 CDS YP_907570.1 118619238 4550098 complement(4512525..4514174) 1 NC_008611.1 activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase 4514174 4550098 MUL_4044 Mycobacterium ulcerans Agy99 long-chain-fatty-acid--CoA ligase YP_907570.1 4512525 R 362242 CDS YP_907571.1 118619239 4550099 complement(4514315..4515505) 1 NC_008611.1 cytoplasmic protein; could be involved in biotin biosynthesis (at the first step) [catalytic activity: 6-carboxyhexanoyl-CoA + L- alanine = 8-amino-7-oxononanoate + CoA + CO2]; 8-amino-7-oxononanoate synthase BioF2 4515505 bioF2 4550099 bioF2 Mycobacterium ulcerans Agy99 8-amino-7-oxononanoate synthase BioF2 YP_907571.1 4514315 R 362242 CDS YP_907572.1 118619240 4550101 complement(4516751..4517584) 1 NC_008611.1 membrane protein; function unknown but domain identity suggests permease component of an uncharacterized ABC-type transport system.; hypothetical protein 4517584 4550101 MUL_4047 Mycobacterium ulcerans Agy99 hypothetical protein YP_907572.1 4516751 R 362242 CDS YP_907573.1 118619241 4550102 complement(4517584..4518264) 1 NC_008611.1 membrane protein; involved in active transport of inorganic phosphate across the membrane (import); responsible for energy coupling to the transport system. this is one of the proteins required for binding-protein-mediated phosphate transport. have ATP-binding ability and ATPase activity.; phosphate-transport ATP-binding protein ABC transporter PstB 4518264 pstB 4550102 pstB Mycobacterium ulcerans Agy99 phosphate-transport ATP-binding protein ABC transporter PstB YP_907573.1 4517584 R 362242 CDS YP_907574.1 118619242 4550104 4519950..4520252 1 NC_008611.1 cytoplasmic protein; members of the PadR-like family are transcriptional regulators that appear to be related to the pfam01047 family. this family includes PadR, a protein that is involved in negative regulation of phenolic acid metabolism.; hypothetical protein 4520252 4550104 MUL_4050 Mycobacterium ulcerans Agy99 hypothetical protein YP_907574.1 4519950 D 362242 CDS YP_907575.1 118619243 4550105 4520320..4520484 1 NC_008611.1 cytoplasmic protein; hypothetical protein 4520484 4550105 MUL_4051 Mycobacterium ulcerans Agy99 hypothetical protein YP_907575.1 4520320 D 362242 CDS YP_907576.1 118619244 4550106 4520485..4521987 1 NC_008611.1 cytoplasmic protein; involved in osmoregulatory trehalose biosynthesis. mycobacteria can produce trehalose from glucose 6- phosphate and UDP-glucose (the OtsA-OtsB pathway) from glycogen-like alpha(1-->4)-linked glucose polymers (the TreY-TreZ pathway) and from maltose (the TreS pathway) [catalytic activity: trehalose 6-phosphate + H(2)O = trehalose + orthophosphate]; alpha, alpha-trehalose-phosphate synthase [UDP- forming] OtsA 4521987 otsA 4550106 otsA Mycobacterium ulcerans Agy99 alpha, alpha-trehalose-phosphate synthase [UDP- forming] OtsA YP_907576.1 4520485 D 362242 CDS YP_907577.1 118619245 4550108 complement(4522702..4523202) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; MCE-associated protein 4523202 4550108 MUL_4055 Mycobacterium ulcerans Agy99 MCE-associated protein YP_907577.1 4522702 R 362242 CDS YP_907578.1 118619246 4550109 complement(4523202..4523933) 1 NC_008611.1 membrane protein; hypothetical protein 4523933 4550109 MUL_4056 Mycobacterium ulcerans Agy99 hypothetical protein YP_907578.1 4523202 R 362242 CDS YP_907579.1 118619247 4550110 complement(4523966..4525648) 1 NC_008611.1 membrane protein; function unknown, but thought involved in host cell invasion.; MCE-family protein Mce4F 4525648 mce4F 4550110 mce4F Mycobacterium ulcerans Agy99 MCE-family protein Mce4F YP_907579.1 4523966 R 362242 CDS YP_907580.1 118619248 4550111 complement(4525660..4526811) 1 NC_008611.1 secreted protein; function unknown, but thought to be involved in host cell invasion.; MCE family lipoprotein LprN 4526811 lprN 4550111 lprN Mycobacterium ulcerans Agy99 MCE family lipoprotein LprN YP_907580.1 4525660 R 362242 CDS YP_907581.1 118619249 4550112 complement(4526808..4528241) 1 NC_008611.1 membrane protein; function unknown, but thought to be involved in host cell invasion.; MCE-family protein Mce4D 4528241 mce4D 4550112 mce4D Mycobacterium ulcerans Agy99 MCE-family protein Mce4D YP_907581.1 4526808 R 362242 CDS YP_907582.1 118619250 4550113 complement(4528238..4529299) 1 NC_008611.1 membrane protein; function unknown, but thought to be involved in host cell invasion.; MCE-family protein Mce4C 4529299 mce4C 4550113 mce4C Mycobacterium ulcerans Agy99 MCE-family protein Mce4C YP_907582.1 4528238 R 362242 CDS YP_907583.1 118619251 4550114 complement(4529289..4530341) 1 NC_008611.1 membrane protein; function unknown, but thought to be involved in host cell invasion.; MCE-family protein Mce4B 4530341 mce4B 4550114 mce4B Mycobacterium ulcerans Agy99 MCE-family protein Mce4B YP_907583.1 4529289 R 362242 CDS YP_907584.1 118619252 4550115 complement(4530341..4531543) 1 NC_008611.1 membrane protein; function unknown, but thought to be involved in host cell invasion.; MCE-family protein Mce4A 4531543 mce4A 4550115 mce4A Mycobacterium ulcerans Agy99 MCE-family protein Mce4A YP_907584.1 4530341 R 362242 CDS YP_907585.1 118619253 4550116 complement(4531559..4532401) 1 NC_008611.1 membrane protein; membrane protein YrbE4B 4532401 yrbE4B 4550116 yrbE4B Mycobacterium ulcerans Agy99 membrane protein YrbE4B YP_907585.1 4531559 R 362242 CDS YP_907586.1 118619254 4550117 complement(4532436..4533275) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; membrane protein YrbE4A 4533275 yrbE4A 4550117 yrbE4A Mycobacterium ulcerans Agy99 membrane protein YrbE4A YP_907586.1 4532436 R 362242 CDS YP_907587.1 118619255 4552606 complement(4533437..4534330) 1 NC_008611.1 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-(acyl-carrier-protein) reductase 4534330 fabG 4552606 fabG Mycobacterium ulcerans Agy99 3-ketoacyl-(acyl-carrier-protein) reductase YP_907587.1 4533437 R 362242 CDS YP_907588.1 118619256 4552607 complement(4534430..4534678) 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS. Also detected in the secreted fraction by proteomics.; cytoplasmic protein; ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.; ferredoxin FdxD 4534678 fdxD 4552607 fdxD Mycobacterium ulcerans Agy99 ferredoxin FdxD YP_907588.1 4534430 R 362242 CDS YP_907589.1 118619257 4552608 4534843..4536021 1 NC_008611.1 Detected in the membrane fraction by proteomics.; membrane protein; function unknown, but involved in lipid degradation.; acyl-CoA dehydrogenase FadE26 4536021 fadE26 4552608 fadE26 Mycobacterium ulcerans Agy99 acyl-CoA dehydrogenase FadE26 YP_907589.1 4534843 D 362242 CDS YP_907590.1 118619258 4552609 4536052..4537149 1 NC_008611.1 cytoplasmic protein; function unknown, but involved in lipid degradation.; acyl-CoA dehydrogenase FadE27 4537149 fadE27 4552609 fadE27 Mycobacterium ulcerans Agy99 acyl-CoA dehydrogenase FadE27 YP_907590.1 4536052 D 362242 CDS YP_907591.1 118619259 4552610 4537212..4538723 1 NC_008611.1 activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 4538723 fadD17 4552610 fadD17 Mycobacterium ulcerans Agy99 acyl-CoA synthetase YP_907591.1 4537212 D 362242 CDS YP_907592.1 118619260 4552612 4540131..4540856 1 NC_008611.1 function unknown but contains beta- lactamase/transpeptidase-like superfamily domain; hypothetical protein 4540856 4552612 MUL_4071 Mycobacterium ulcerans Agy99 hypothetical protein YP_907592.1 4540131 D 362242 CDS YP_907593.1 118619261 4552613 complement(4540853..4542400) 1 NC_008611.1 thiamine-pyrophosphate requiring enzyme; hypothetical protein 4542400 ilvX 4552613 ilvX Mycobacterium ulcerans Agy99 hypothetical protein YP_907593.1 4540853 R 362242 CDS YP_907594.1 118619262 4552615 complement(4543296..4544063) 1 NC_008611.1 cytoplasmic protein; fructosamine kinase-like protein 4544063 4552615 MUL_4074 Mycobacterium ulcerans Agy99 fructosamine kinase-like protein YP_907594.1 4543296 R 362242 CDS YP_907595.1 118619263 4552616 complement(4544077..4545729) 1 NC_008611.1 activates fatty acids by binding to coenzyme A; in Mycobacterium may be involved in virulence; acyl-CoA synthetase 4545729 fadD19_1 4552616 fadD19_1 Mycobacterium ulcerans Agy99 acyl-CoA synthetase YP_907595.1 4544077 R 362242 CDS YP_907596.1 118619264 4552617 4545764..4546618 1 NC_008611.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 4546618 echA19 4552617 echA19 Mycobacterium ulcerans Agy99 enoyl-CoA hydratase YP_907596.1 4545764 D 362242 CDS YP_907597.1 118619265 4552618 complement(4546636..4547847) 1 NC_008611.1 cytoplasmic protein; cytochromes P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.; cytochrome P450 142A3 Cyp142A3 4547847 cyp142A3 4552618 cyp142A3 Mycobacterium ulcerans Agy99 cytochrome P450 142A3 Cyp142A3 YP_907597.1 4546636 R 362242 CDS YP_907598.1 118619266 4552619 4547871..4548581 1 NC_008611.1 cytoplasmic protein; hypothetical protein 4548581 4552619 MUL_4078 Mycobacterium ulcerans Agy99 hypothetical protein YP_907598.1 4547871 D 362242 CDS YP_907599.1 118619267 4552620 complement(4548642..4549679) 1 NC_008611.1 cytoplasmic protein; function unknown, probably involved in cellular metabolism.; coenzyme F420-dependent oxidoreductase 4549679 4552620 MUL_4079 Mycobacterium ulcerans Agy99 coenzyme F420-dependent oxidoreductase YP_907599.1 4548642 R 362242 CDS YP_907600.1 118619268 4552621 4549750..4550739 1 NC_008611.1 cytoplasmic protein; function unknown, contains a C-term predicted nucleic-acid-binding domain; hypothetical protein 4550739 4552621 MUL_4080 Mycobacterium ulcerans Agy99 hypothetical protein YP_907600.1 4549750 D 362242 CDS YP_907601.1 118619269 4552622 4550755..4551816 1 NC_008611.1 cytoplasmic protein; function unknown, probably involved in lipid metabolism.; lipid-transfer protein 4551816 ltp4 4552622 ltp4 Mycobacterium ulcerans Agy99 lipid-transfer protein YP_907601.1 4550755 D 362242 CDS YP_907602.1 118619270 4551358 4551816..4552994 1 NC_008611.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; acetyl-CoA acetyltransferase 4552994 ltp3 4551358 ltp3 Mycobacterium ulcerans Agy99 acetyl-CoA acetyltransferase YP_907602.1 4551816 D 362242 CDS YP_907603.1 118619271 4551359 4553000..4553881 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; function unknown, probably involved in cellular metabolism.; oxidoreductase 4553881 4551359 MUL_4083 Mycobacterium ulcerans Agy99 oxidoreductase YP_907603.1 4553000 D 362242 CDS YP_907604.1 118619272 4551360 4553878..4554288 1 NC_008611.1 cytoplasmic protein; function unknown, this class of proteins is involved in enzymatic cleavage of a C-H bond adjacent to carbonyl or a carboxyl group, leading to an enol or a enolate intermediate that is subsequently re-protonated at the same or an adjacent carbon.; ketosteroid isomerase- like protein 4554288 4551360 MUL_4084 Mycobacterium ulcerans Agy99 ketosteroid isomerase- like protein YP_907604.1 4553878 D 362242 CDS YP_907605.1 118619273 4551363 complement(4558214..4558738) 1 NC_008611.1 cytoplasmic protein; function unknown, contains carbonic anhydrases/acetyltransferase superfamily domain; hypothetical protein 4558738 4551363 MUL_4088 Mycobacterium ulcerans Agy99 hypothetical protein YP_907605.1 4558214 R 362242 CDS YP_907606.1 118619274 4551364 4558852..4560036 1 NC_008611.1 cytoplasmic protein; function unknown, probably involved in cellular metabolism.; oxidoreductase 4560036 4551364 MUL_4089 Mycobacterium ulcerans Agy99 oxidoreductase YP_907606.1 4558852 D 362242 CDS YP_907607.1 118619275 4551365 4560042..4560491 1 NC_008611.1 cytoplasmic protein; hypothetical protein 4560491 4551365 MUL_4090 Mycobacterium ulcerans Agy99 hypothetical protein YP_907607.1 4560042 D 362242 CDS YP_907608.1 118619276 4551366 complement(4560495..4561640) 1 NC_008611.1 cytoplasmic protein; function unknown, contains P-loop containing nucleoside triphosphate hydrolase superfamily domain; hypothetical protein 4561640 4551366 MUL_4091 Mycobacterium ulcerans Agy99 hypothetical protein YP_907608.1 4560495 R 362242 CDS YP_907609.1 118619277 4551367 complement(4561640..4562380) 1 NC_008611.1 cytoplasmic protein; function unknown, probably involved in cellular metabolism.; short chain dehydrogenase 4562380 4551367 MUL_4092 Mycobacterium ulcerans Agy99 short chain dehydrogenase YP_907609.1 4561640 R 362242 CDS YP_907610.1 118619278 4551368 complement(4562436..4563569) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 4563569 4551368 MUL_4093 Mycobacterium ulcerans Agy99 hypothetical protein YP_907610.1 4562436 R 362242 CDS YP_907611.1 118619279 4551369 4563831..4566416 1 NC_008611.1 cytoplasmic protein; function unknown, this enzyme catalyses the first and rate limiting step in de novo glutathione biosynthesis.; glutamate--cysteine ligase, Gcs2 4566416 gcs2 4551369 gcs2 Mycobacterium ulcerans Agy99 glutamate--cysteine ligase, Gcs2 YP_907611.1 4563831 D 362242 CDS YP_907612.1 118619280 4551370 complement(4566403..4567446) 1 NC_008611.1 catalyzes the formation of pyruvate and acetaldehyde from 4-hydroxy-2-ketovaleric acid; involved in the degradation of phenylpropionate; 4-hydroxy-2-ketovalerate aldolase 4567446 4551370 MUL_4095 Mycobacterium ulcerans Agy99 4-hydroxy-2-ketovalerate aldolase YP_907612.1 4566403 R 362242 CDS YP_907613.1 118619281 4551371 complement(4567443..4568369) 1 NC_008611.1 catalyzes the formation of acetyl-CoA from acetalaldehyde; acetaldehyde dehydrogenase 4568369 mhpF_1 4551371 mhpF_1 Mycobacterium ulcerans Agy99 acetaldehyde dehydrogenase YP_907613.1 4567443 R 362242 CDS YP_907614.1 118619282 4551372 complement(4568413..4569357) 1 NC_008611.1 cytoplasmic protein; function unknown, probably involved in cellular metabolism.; 2-keto-4-pentenoate hydratase 4569357 4551372 MUL_4097 Mycobacterium ulcerans Agy99 2-keto-4-pentenoate hydratase YP_907614.1 4568413 R 362242 CDS YP_907615.2 162138268 4551373 4569282..4570976 1 NC_008611.1 initiates steroid ring degradation; catalyzes the transhydrogenation of 3-keto-4-ene-steroid to 3-keto-1,4-diene-steroid e.g., progesterone to 1,4-androstadiene-3,17-dione; 3-ketosteroid-delta-1-dehydrogenase 4570976 4551373 MUL_4098 Mycobacterium ulcerans Agy99 3-ketosteroid-delta-1-dehydrogenase YP_907615.2 4569282 D 362242 CDS YP_907616.1 118619284 4551374 4570978..4571847 1 NC_008611.1 cytoplasmic protein; function unknown, probably involved in cellular metabolism.; dehydratase (MaoC-like) 4571847 4551374 MUL_4099 Mycobacterium ulcerans Agy99 dehydratase (MaoC-like) YP_907616.1 4570978 D 362242 CDS YP_907617.1 118619285 4551375 complement(4572067..4572780) 1 NC_008611.1 cytoplasmic protein; function unknown, contains restriction endonuclease- like superfamily domain; hypothetical protein 4572780 4551375 MUL_4100 Mycobacterium ulcerans Agy99 hypothetical protein YP_907617.1 4572067 R 362242 CDS YP_907618.1 118619286 4551376 complement(4572911..4574071) 1 NC_008611.1 cytoplasmic protein; function unknown, supposed involvement in lipid metabolism.; lipid-transfer protein 4574071 ltp2_1 4551376 ltp2_1 Mycobacterium ulcerans Agy99 lipid-transfer protein YP_907618.1 4572911 R 362242 CDS YP_907619.1 118619287 4552414 complement(4574071..4574457) 1 NC_008611.1 cytoplasmic protein; function unknown, potential role in lipid metabolism. contains thioesterase/thiol ester dehydrase- isomerase superfamily domain.; hypothetical protein 4574457 4552414 MUL_4102 Mycobacterium ulcerans Agy99 hypothetical protein YP_907619.1 4574071 R 362242 CDS YP_907620.1 118619288 4552415 complement(4574469..4575419) 1 NC_008611.1 cytoplasmic protein; function unknown, contains a predicted C-term nucleic-acid-binding protein; hypothetical protein 4575419 4552415 MUL_4103 Mycobacterium ulcerans Agy99 hypothetical protein YP_907620.1 4574469 R 362242 CDS YP_907621.1 118619289 4552416 complement(4575416..4576579) 1 NC_008611.1 Detected in the cytoplasmic fraction by proteomics.; cytoplasmic protein; function unknown, but involved in lipid degradation.; acyl-CoA dehydrogenase FadE29 4576579 fadE29 4552416 fadE29 Mycobacterium ulcerans Agy99 acyl-CoA dehydrogenase FadE29 YP_907621.1 4575416 R 362242 CDS YP_907622.1 118619290 4552417 complement(4576564..4577595) 1 NC_008611.1 cytoplasmic protein; function unknown, but involved in lipid degradation.; acyl-CoA dehydrogenase FadE28 4577595 fadE28 4552417 fadE28 Mycobacterium ulcerans Agy99 acyl-CoA dehydrogenase FadE28 YP_907622.1 4576564 R 362242 CDS YP_907623.1 118619291 4552418 complement(4577613..4578866) 1 NC_008611.1 cytoplasmic protein; cytochromes P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.; cytochrome P450 125A7 Cyp125A7 4578866 cyp125A7 4552418 cyp125A7 Mycobacterium ulcerans Agy99 cytochrome P450 125A7 Cyp125A7 YP_907623.1 4577613 R 362242 CDS YP_907624.1 118619292 4552419 4579037..4580212 1 NC_008611.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; acetyl-CoA acetyltransferase 4580212 fadA5 4552419 fadA5 Mycobacterium ulcerans Agy99 acetyl-CoA acetyltransferase YP_907624.1 4579037 D 362242 CDS YP_907625.1 118619293 4552421 4580675..4581172 1 NC_008611.1 cytoplasmic protein; function unknown, contains a FMN-binding split barrel domain. possible role in the electron-transfer pathway. the FMN-binding split barrel is related to the ferredoxin reductase-like FAD-binding domain. flavodoxins are an example of a group of proteins with a tightly bound flavin mononucleotide (FMN) that mediate electron transfer at low redox potential.; hypothetical protein 4581172 4552421 MUL_4109 Mycobacterium ulcerans Agy99 hypothetical protein YP_907625.1 4580675 D 362242 CDS YP_907626.1 118619294 4552422 complement(4581193..4582098) 1 NC_008611.1 cytoplasmic protein; function unknown, supposed involvement in cellular metabolism.; short chain dehydrogenase 4582098 4552422 MUL_4110 Mycobacterium ulcerans Agy99 short chain dehydrogenase YP_907626.1 4581193 R 362242 CDS YP_907627.1 118619295 4552423 complement(4582119..4582898) 1 NC_008611.1 cytoplasmic protein; function unknown, supposed involvement in cellular metabolism.; short chain dehydrogenase 4582898 4552423 MUL_4111 Mycobacterium ulcerans Agy99 short chain dehydrogenase YP_907627.1 4582119 R 362242 CDS YP_907628.1 118619296 4552425 4585247..4585990 1 NC_008611.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 4585990 echA20 4552425 echA20 Mycobacterium ulcerans Agy99 enoyl-CoA hydratase YP_907628.1 4585247 D 362242 CDS YP_907629.1 118619297 4552426 4585987..4586865 1 NC_008611.1 cytoplasmic protein; function unknown. possible subunit of a CoA- transferase, catalyzing the reversible of CoA from one carboxylic acid to another.; CoA-transferase (alpha subunit) 4586865 4552426 MUL_4114 Mycobacterium ulcerans Agy99 CoA-transferase (alpha subunit) YP_907629.1 4585987 D 362242 CDS YP_907630.1 118619298 4552427 4586862..4587605 1 NC_008611.1 cytoplasmic protein; function unknown. possible subunit of a CoA- transferase, catalyzing the reversible of CoA from one carboxylic acid to another.; CoA-transferase (beta subunit) 4587605 4552427 MUL_4115 Mycobacterium ulcerans Agy99 CoA-transferase (beta subunit) YP_907630.1 4586862 D 362242 CDS YP_907631.1 118619299 4552428 4587602..4588669 1 NC_008611.1 cytoplasmic protein; function unknown, members of this family catalyse the denitrification of a number of nitroalkanes using either fad or FMN as a cofactor.; 2-nitropropane dioxygenase 4588669 4552428 MUL_4116 Mycobacterium ulcerans Agy99 2-nitropropane dioxygenase YP_907631.1 4587602 D 362242 CDS YP_907632.1 118619300 4552429 4588700..4590721 1 NC_008611.1 membrane protein; function unknown, c-terminus probably involved in electron transfer in one or several metabolic reactions.; electron transfer protein FdxB 4590721 fdxB 4552429 fdxB Mycobacterium ulcerans Agy99 electron transfer protein FdxB YP_907632.1 4588700 D 362242 CDS YP_907633.1 118619301 4552431 complement(4592854..4594014) 1 NC_008611.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; acetyl-CoA acetyltransferase 4594014 fadA6_1 4552431 fadA6_1 Mycobacterium ulcerans Agy99 acetyl-CoA acetyltransferase YP_907633.1 4592854 R 362242 CDS YP_907634.1 118619302 4552432 complement(4594017..4594574) 1 NC_008611.1 cytoplasmic protein; involved in transcriptional mechanism.; TetR family transcriptional regulator 4594574 4552432 MUL_4120 Mycobacterium ulcerans Agy99 TetR family transcriptional regulator YP_907634.1 4594017 R 362242 CDS YP_907635.1 118619303 4552286 complement(4595302..4596348) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 4596348 4552286 MUL_4122 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_907635.1 4595302 R 362242 CDS YP_907636.1 118619304 4552288 complement(4597857..4598645) 1 NC_008611.1 cytoplasmic protein; function unknown, probably involved in cellular metabolism.; short chain dehydrogenase 4598645 4552288 MUL_4124 Mycobacterium ulcerans Agy99 short chain dehydrogenase YP_907636.1 4597857 R 362242 CDS YP_907637.1 118619305 4552289 complement(4598642..4599790) 1 NC_008611.1 cytoplasmic protein; function unknown, but involved in lipid degradation.; acyl-CoA dehydrogenase FadE30 4599790 fadE30 4552289 fadE30 Mycobacterium ulcerans Agy99 acyl-CoA dehydrogenase FadE30 YP_907637.1 4598642 R 362242 CDS YP_907638.1 118619306 4552290 4599861..4601384 1 NC_008611.1 activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase 4601384 fadD3 4552290 fadD3 Mycobacterium ulcerans Agy99 long-chain-fatty-acid--CoA ligase YP_907638.1 4599861 D 362242 CDS YP_907639.1 118619307 4552291 4601385..4602518 1 NC_008611.1 cytoplasmic protein; function unknown, but involved in lipid degradation.; acyl-CoA dehydrogenase FadE31 4602518 fadE31 4552291 fadE31 Mycobacterium ulcerans Agy99 acyl-CoA dehydrogenase FadE31 YP_907639.1 4601385 D 362242 CDS YP_907640.1 118619308 4552292 4602522..4603457 1 NC_008611.1 cytoplasmic protein; function unknown, but involved in lipid degradation.; acyl-CoA dehydrogenase FadE32 4603457 fadE32 4552292 fadE32 Mycobacterium ulcerans Agy99 acyl-CoA dehydrogenase FadE32 YP_907640.1 4602522 D 362242 CDS YP_907641.1 118619309 4552293 4603507..4604469 1 NC_008611.1 cytoplasmic protein; function unknown, but involved in lipid degradation.; acyl-CoA dehydrogenase FadE33 4604469 fadE33 4552293 fadE33 Mycobacterium ulcerans Agy99 acyl-CoA dehydrogenase FadE33 YP_907641.1 4603507 D 362242 CDS YP_907642.1 118619310 4552294 4604466..4605641 1 NC_008611.1 catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate; aspartate aminotransferase 4605641 aspB 4552294 aspB Mycobacterium ulcerans Agy99 aspartate aminotransferase YP_907642.1 4604466 D 362242 CDS YP_907643.1 118619311 4552295 complement(4605655..4606497) 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; could have a role in acetylating, and hence inactivating, the antitubercular drug isoniazid [catalytic activity: acetyl-CoA + arylamine = CoA + N- acetylarylamine]; arylamine N-acetyltransferase Nat 4606497 nat 4552295 nat Mycobacterium ulcerans Agy99 arylamine N-acetyltransferase Nat YP_907643.1 4605655 R 362242 CDS YP_907644.1 118619312 4552296 4606650..4607261 1 NC_008611.1 cytoplasmic protein; function unknown.; hypothetical protein 4607261 4552296 MUL_4132 Mycobacterium ulcerans Agy99 hypothetical protein YP_907644.1 4606650 D 362242 CDS YP_907645.1 118619313 4552297 4607561..4608136 1 NC_008611.1 Detected in the secreted fraction by proteomics.; secreted protein; function unknown, possibly involved in thiol:disulfide interchange. contains PS00013 prokaryotic membrane lipoprotein lipid attachment site, N-term signal pepitde sequence and PS00194 thioredoxin family active site.; lipoprotein DsbF 4608136 dsbF 4552297 dsbF Mycobacterium ulcerans Agy99 lipoprotein DsbF YP_907645.1 4607561 D 362242 CDS YP_907646.1 118619314 4552299 complement(4609014..4609946) 1 NC_008611.1 membrane protein; function unknown, but domain identity suggests this protein may have metalloendopeptidase activity.; peptidase M48 like- protein 4609946 4552299 MUL_4135 Mycobacterium ulcerans Agy99 peptidase M48 like- protein YP_907646.1 4609014 R 362242 CDS YP_907647.1 118619315 4552300 complement(4609943..4610449) 1 NC_008611.1 cytoplasmic protein; involved in transcriptional mechanism.; transcriptional regulatory protein 4610449 4552300 MUL_4136 Mycobacterium ulcerans Agy99 transcriptional regulatory protein YP_907647.1 4609943 R 362242 CDS YP_907648.1 118619316 4552301 4610470..4610877 1 NC_008611.1 secreted protein; hypothetical protein 4610877 4552301 MUL_4137 Mycobacterium ulcerans Agy99 hypothetical protein YP_907648.1 4610470 D 362242 CDS YP_907649.1 118619317 4552302 complement(4610963..4611529) 1 NC_008611.1 cytoplasmic protein; function unknown, probably involved in cellular metabolism.; oxidase 4611529 4552302 MUL_4138 Mycobacterium ulcerans Agy99 oxidase YP_907649.1 4610963 R 362242 CDS YP_907650.1 118619318 4551843 complement(4611541..4612443) 1 NC_008611.1 cytoplasmic protein; involved in the degradation of biphenyl [catalytic activity: biphenyl-2,3-diol + O(2) = 2-hydroxy-6-oxo-6- phenylhexa-2,4-dienoate + H(2)O]; biphenyl-2,3-diol 1,2-dioxygenase BphC 4612443 bphC 4551843 bphC Mycobacterium ulcerans Agy99 biphenyl-2,3-diol 1,2-dioxygenase BphC YP_907650.1 4611541 R 362242 CDS YP_907651.1 118619319 4551844 complement(4612440..4613327) 1 NC_008611.1 cytoplasmic protein; involved in the degradation of biphenyl.; 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD 4613327 bphD 4551844 bphD Mycobacterium ulcerans Agy99 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD YP_907651.1 4612440 R 362242 CDS YP_907652.1 118619320 4551845 complement(4613327..4614511) 1 NC_008611.1 cytoplasmic protein; function unknown, probably involved in cellular metabolism.; acyl-CoA dehydrogenase 4614511 4551845 MUL_4141 Mycobacterium ulcerans Agy99 acyl-CoA dehydrogenase YP_907652.1 4613327 R 362242 CDS YP_907653.1 118619321 4551846 4614705..4615781 1 NC_008611.1 cytoplasmic protein; may play a role in protection from oxidative (nitric oxide) and nitrosative stress. may also be involved in anaerobic metabolism. could have nitric oxide dioxygenase activity.; flavodoxin reductase Hmp 4615781 hmp 4551846 hmp Mycobacterium ulcerans Agy99 flavodoxin reductase Hmp YP_907653.1 4614705 D 362242 CDS YP_907654.1 118619322 4551847 4615827..4616357 1 NC_008611.1 secreted protein; hypothetical protein 4616357 4551847 MUL_4143 Mycobacterium ulcerans Agy99 hypothetical protein YP_907654.1 4615827 D 362242 CDS YP_907655.1 118619323 4551848 complement(4616373..4618508) 1 NC_008611.1 cytoplasmic protein; function unknown, but involved in lipid degradation.; acyl-CoA dehydrogenase FadE34 4618508 fadE34 4551848 fadE34 Mycobacterium ulcerans Agy99 acyl-CoA dehydrogenase FadE34 YP_907655.1 4616373 R 362242 CDS YP_907656.1 118619324 4551849 4618790..4619392 1 NC_008611.1 cytoplasmic protein; involved in transcriptional mechanism.; TetR family transcriptional regulator 4619392 4551849 MUL_4145 Mycobacterium ulcerans Agy99 TetR family transcriptional regulator YP_907656.1 4618790 D 362242 CDS YP_907657.1 118619325 4551850 complement(4619399..4620478) 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; involved in transcriptional mechanism.; PurR family transcriptional regulator 4620478 4551850 MUL_4146 Mycobacterium ulcerans Agy99 PurR family transcriptional regulator YP_907657.1 4619399 R 362242 CDS YP_907658.1 118619326 4551851 4620574..4621479 1 NC_008611.1 membrane protein; function unknown, domain identity suggests periplasmic solute binding protein, containing an ATP- binding cassette transport system; hypothetical protein 4621479 4551851 MUL_4147 Mycobacterium ulcerans Agy99 hypothetical protein YP_907658.1 4620574 D 362242 CDS YP_907659.1 118619327 4551852 4621488..4622306 1 NC_008611.1 membrane protein; function unknown, part of a binding-protein- dependent ABC transport system; ATPase component of an ABC-type transport system 4622306 4551852 MUL_4148 Mycobacterium ulcerans Agy99 ATPase component of an ABC-type transport system YP_907659.1 4621488 D 362242 CDS YP_907660.1 118619328 4551853 4622303..4623154 1 NC_008611.1 membrane protein; part of an ABC transport system; permease component of an ABC-type transporter 4623154 4551853 MUL_4149 Mycobacterium ulcerans Agy99 permease component of an ABC-type transporter YP_907660.1 4622303 D 362242 CDS YP_907661.1 118619329 4551854 4623241..4623957 1 NC_008611.1 secreted protein; lipoprotein LppH 4623957 lppH 4551854 lppH Mycobacterium ulcerans Agy99 lipoprotein LppH YP_907661.1 4623241 D 362242 CDS YP_907662.1 118619330 4551855 4623972..4624721 1 NC_008611.1 membrane protein; lipoprotein 4624721 4551855 MUL_4151 Mycobacterium ulcerans Agy99 lipoprotein YP_907662.1 4623972 D 362242 CDS YP_907663.1 118619331 4551856 4624740..4625498 1 NC_008611.1 cytoplasmic protein; function unknown, the lam locus of aspergillus nidulans consists of two divergently transcribed genes, lama and Lamb, involved in the utilization of lactams such as 2-pyrrolidinone. both genes are under the control of the positive regulatory gene AmdR and are subject to carbon and nitrogen metabolite repression. the exact molecular function of the proteins in this family is unknown.; LamB/YcsF family protein 4625498 lamB 4551856 lamB Mycobacterium ulcerans Agy99 LamB/YcsF family protein YP_907663.1 4624740 D 362242 CDS YP_907664.1 118619332 4551857 4625498..4626418 1 NC_008611.1 cytoplasmic protein; hypothetical protein 4626418 4551857 MUL_4153 Mycobacterium ulcerans Agy99 hypothetical protein YP_907664.1 4625498 D 362242 CDS YP_907665.1 118619333 4551858 4626441..4627682 1 NC_008611.1 membrane protein; thought to be involved in transport of arsenic across the membrane (export): arsenic resistance by an export mechanism. form the channel of an arsenite pump responsible for the translocation of the substrate across the membrane.; arsenical pump integral membrane protein ArsB2 4627682 arsB2 4551858 arsB2 Mycobacterium ulcerans Agy99 arsenical pump integral membrane protein ArsB2 YP_907665.1 4626441 D 362242 CDS YP_907666.1 118619334 4551859 complement(4627705..4628637) 1 NC_008611.1 Detected in the membrane fraction by proteomics.; cytoplasmic protein; function unknown role in tRNA and rRNA base modification by methylation.; tRNA/rRNA methyltransferase 4628637 4551859 MUL_4155 Mycobacterium ulcerans Agy99 tRNA/rRNA methyltransferase YP_907666.1 4627705 R 362242 CDS YP_907667.1 118619335 4551860 complement(4628638..4630044) 1 NC_008611.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA; cysteinyl-tRNA synthetase 4630044 cysS 4551860 cysS Mycobacterium ulcerans Agy99 cysteinyl-tRNA synthetase YP_907667.1 4628638 R 362242 CDS YP_907668.1 118619336 4551861 complement(4630102..4630581) 1 NC_008611.1 catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate; 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 4630581 ispF 4551861 ispF Mycobacterium ulcerans Agy99 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase YP_907668.1 4630102 R 362242 CDS YP_907669.1 118619337 4551582 complement(4630596..4631279) 1 NC_008611.1 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase 4631279 ispD 4551582 ispD Mycobacterium ulcerans Agy99 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase YP_907669.1 4630596 R 362242 CDS YP_907670.1 118619338 4551583 complement(4631296..4631784) 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; function unknown role in regulation; transcriptional regulatory protein 4631784 4551583 MUL_4159 Mycobacterium ulcerans Agy99 transcriptional regulatory protein YP_907670.1 4631296 R 362242 CDS YP_907671.1 118619339 4551584 4632227..4632784 1 NC_008611.1 membrane protein; lipoprotein LpqE 4632784 lpqE 4551584 lpqE Mycobacterium ulcerans Agy99 lipoprotein LpqE YP_907671.1 4632227 D 362242 CDS YP_907672.1 118619340 4551586 4634325..4635401 1 NC_008611.1 non-specific DNA-binding; scans chromosomes during sporulation for DNA-damage; delays initiation of sporulation; participates in a checkpoint signaling cascade for cell-cycle progression and DNA repair; DNA integrity scanning protein DisA 4635401 4551586 MUL_4162 Mycobacterium ulcerans Agy99 DNA integrity scanning protein DisA YP_907672.1 4634325 D 362242 CDS YP_907673.1 118619341 4551587 complement(4635413..4636234) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS) Also detected in the secreted protein fraction; membrane protein; hypothetical protein 4636234 4551587 MUL_4163 Mycobacterium ulcerans Agy99 hypothetical protein YP_907673.1 4635413 R 362242 CDS YP_907674.1 118619342 4551588 complement(4636324..4636941) 1 NC_008611.1 cytoplasmic protein; catalyzes the reversible hydratation of carbon dioxide [catalytic activity: H(2)CO(3) = CO(2) + H(2)O]; carbonic anhydrase 4636941 4551588 MUL_4164 Mycobacterium ulcerans Agy99 carbonic anhydrase YP_907674.1 4636324 R 362242 CDS YP_907675.1 118619343 4551589 4636940..4637851 1 NC_008611.1 cytoplasmic protein; involved in base excision repair. removes adenine mispaired with 8-OXOG. may repair a.G and a.C mismatches by adenine excision.; adenine glycosylase MutY 4637851 mutY 4551589 mutY Mycobacterium ulcerans Agy99 adenine glycosylase MutY YP_907675.1 4636940 D 362242 CDS YP_907676.1 118619344 4551590 complement(4637859..4638626) 1 NC_008611.1 cytoplasmic protein; function unknown, probably involved in cellular metabolism.; hydrolase 4638626 4551590 MUL_4166 Mycobacterium ulcerans Agy99 hydrolase YP_907676.1 4637859 R 362242 CDS YP_907677.1 118619345 4551592 4639031..4640344 1 NC_008611.1 membrane protein; lipoprotein LpqF 4640344 lpqF 4551592 lpqF Mycobacterium ulcerans Agy99 lipoprotein LpqF YP_907677.1 4639031 D 362242 CDS YP_907678.1 118619346 4551593 complement(4640202..4641164) 1 NC_008611.1 cytoplasmic protein; transfers mannose from GDP-mannose to all endogenous polyprenol-phosphates.; polyprenol-monophosphomannose synthase Ppm1_2 4641164 ppm1_2 4551593 ppm1_2 Mycobacterium ulcerans Agy99 polyprenol-monophosphomannose synthase Ppm1_2 YP_907678.1 4640202 R 362242 CDS YP_907679.1 118619347 4551594 complement(4641161..4642729) 1 NC_008611.1 membrane protein; thought to be involved in a transport system across the membrane (perhaps drug transport): responsible for the translocation of the substrate across the membrane.; integral membrane transport protein 4642729 4551594 MUL_4170 Mycobacterium ulcerans Agy99 integral membrane transport protein YP_907679.1 4641161 R 362242 CDS YP_907680.1 118619348 4551596 complement(4644060..4644593) 1 NC_008611.1 cytoplasmic protein; may be involved in the catalysis of both the synthesis and the degradation of fructose-2,6- bisphosphate. beta-D-fructose 2,6-bisphosphate + H(2)O <=> D-fructose 6-phosphate + phosphate.; fructose-2,6-bisphosphatase GpmB 4644593 gpmB 4551596 gpmB Mycobacterium ulcerans Agy99 fructose-2,6-bisphosphatase GpmB YP_907680.1 4644060 R 362242 CDS YP_907681.1 118619349 4551597 complement(4644601..4645368) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; hypothetical protein 4645368 4551597 MUL_4173 Mycobacterium ulcerans Agy99 hypothetical protein YP_907681.1 4644601 R 362242 CDS YP_907682.1 118619350 4551598 complement(4645383..4645598) 1 NC_008611.1 membrane protein; hypothetical protein 4645598 4551598 MUL_4174 Mycobacterium ulcerans Agy99 hypothetical protein YP_907682.1 4645383 R 362242 CDS YP_907683.1 118619351 4549741 complement(4646777..4647823) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 4647823 4549741 MUL_4176 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_907683.1 4646777 R 362242 CDS YP_907684.1 118619352 4549743 complement(4648646..4651195) 1 NC_008611.1 Also detected in the extracellular matrix by proteomics.; cytoplasmic protein; hydrolyses proteins in presence of ATP. may interact with a ClpP-like protease involved in degradation of denatured proteins.; ATP-dependent protease ATP-binding subunit ClpC1 4651195 clpC1 4549743 clpC1 Mycobacterium ulcerans Agy99 ATP-dependent protease ATP-binding subunit ClpC1 YP_907684.1 4648646 R 362242 CDS YP_907685.1 118619353 4549744 complement(4651370..4652416) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 4652416 4549744 MUL_4179 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_907685.1 4651370 R 362242 CDS YP_907686.1 118619354 4549745 complement(4652949..4653290) 1 NC_008611.1 Detected in the cytoplasmic and the extracellular matrix fractions by proteomics.; extracellular matrix protein; dominant T-cell antigen and may stimulate lymphocyte proliferation.; iron-regulated Lsr2 protein precursor 4653290 lsr2 4549745 lsr2 Mycobacterium ulcerans Agy99 iron-regulated Lsr2 protein precursor YP_907686.1 4652949 R 362242 CDS YP_907687.1 118619355 4549746 complement(4653405..4654901) 1 NC_008611.1 class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1; lysyl-tRNA synthetase 4654901 lysS 4549746 lysS Mycobacterium ulcerans Agy99 lysyl-tRNA synthetase YP_907687.1 4653405 R 362242 CDS YP_907688.1 118619356 4549747 complement(4655023..4655841) 1 NC_008611.1 type III; catalyzes the formation of (R)-4'-phosphopantothenate from (R)-pantothenate in coenzyme A biosynthesis; type III pantothenate kinases are not subject to feedback inhibition from coenzyme A and have a high Km for ATP; pantothenate kinase 4655841 4549747 MUL_4182 Mycobacterium ulcerans Agy99 pantothenate kinase YP_907688.1 4655023 R 362242 CDS YP_907689.1 118619357 4549748 complement(4655844..4656263) 1 NC_008611.1 Converts L-aspartate to beta-alanine and provides the major route of beta-alanine production in bacteria. Beta-alanine is essential for the biosynthesis of pantothenate (vitamin B5); aspartate alpha-decarboxylase 4656263 panD 4549748 panD Mycobacterium ulcerans Agy99 aspartate alpha-decarboxylase YP_907689.1 4655844 R 362242 CDS YP_907690.1 118619358 4549749 complement(4656275..4657222) 1 NC_008611.1 catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine; pantoate--beta-alanine ligase 4657222 panC 4549749 panC Mycobacterium ulcerans Agy99 pantoate--beta-alanine ligase YP_907690.1 4656275 R 362242 CDS YP_907691.1 118619359 4549750 complement(4657219..4658130) 1 NC_008611.1 function unknown contains NAD(P)-binding Rossmann- fold superfamily domains; hypothetical protein 4658130 4549750 MUL_4185 Mycobacterium ulcerans Agy99 hypothetical protein YP_907691.1 4657219 R 362242 CDS YP_907692.1 118619360 4549751 complement(4658233..4659585) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; transmembrane protein rich in alanine, arginine and proline 4659585 4549751 MUL_4186 Mycobacterium ulcerans Agy99 transmembrane protein rich in alanine, arginine and proline YP_907692.1 4658233 R 362242 CDS YP_907693.1 118619361 4549752 complement(4659697..4660173) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; hypothetical protein 4660173 4549752 MUL_4187 Mycobacterium ulcerans Agy99 hypothetical protein YP_907693.1 4659697 R 362242 CDS YP_907694.1 118619362 4549753 complement(4660173..4660700) 1 NC_008611.1 cytoplasmic protein; involved in dihydrofolate biosynthesis (at the first step) [catalytic activity: ATP + 2-amino-4-hydroxy-6- hydroxymethyl-7,8-dihydropteridine = AMP + 2-amino-7,8- dihydro-4-hydroxy-6-(diphosphooxymethyl)pteri di ne]; 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase FolK 4660700 folK 4549753 folK Mycobacterium ulcerans Agy99 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase FolK YP_907694.1 4660173 R 362242 CDS YP_907695.1 118619363 4549754 complement(4660697..4661098) 1 NC_008611.1 cytoplasmic protein; involved in folate biosynthesis. catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8- dihydropterin (by similarity) [catalytic activity: 2-amino- 4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7, 8- dihydropteridine = 2-amino-4-hydroxy-6-hydroxymethyl-7,8- dihydropteridine + glycolaldehyde]; dihydroneopterin aldolase FolB 4661098 folB 4549754 folB Mycobacterium ulcerans Agy99 dihydroneopterin aldolase FolB YP_907695.1 4660697 R 362242 CDS YP_907696.1 118619364 4549755 complement(4661091..4661909) 1 NC_008611.1 cytoplasmic protein; involved in dihydrofolate biosynthesis (at the second step) catalyzes the formation of the immediate precursor of folic acid. it is implicated in resistance to sulfonamide [catalytic activity: 2-amino-4-hydroxy-6- hydroxymethyl-7,8-dihydropteridine diphosphate + 4- aminobenzoate = pyrophosphate + dihydropteroate]; dihydropteroate synthase 1 FolP1 4661909 folP1 4549755 folP1 Mycobacterium ulcerans Agy99 dihydropteroate synthase 1 FolP1 YP_907696.1 4661091 R 362242 CDS YP_907697.1 118619365 4549756 complement(4661930..4662538) 1 NC_008611.1 involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer; GTP cyclohydrolase I 4662538 folE 4549756 folE Mycobacterium ulcerans Agy99 GTP cyclohydrolase I YP_907697.1 4661930 R 362242 CDS YP_907698.1 118619366 4549757 complement(4662555..4664777) 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS. Also detected in the membrane fraction by proteomics (LC-MS/MS); membrane protein; thought to act as an ATP-dependent zinc metallopeptidase, with ATPase and proteolytic activities. probably has a regulatory role in stress response and specific proteins secretion for adaptation to host environment.; membrane-bound protease FtsH 4664777 ftsH 4549757 ftsH Mycobacterium ulcerans Agy99 membrane-bound protease FtsH YP_907698.1 4662555 R 362242 CDS YP_907699.1 118619367 4550909 4665017..4665985 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; biotransformation enzyme that catalyzes the hydrolysis of epoxides (alkene oxides, oxiranes) and Arene oxides to less reactive and more water soluble dihydrodiols by the trans addition of water. thought to be involved in detoxification reactions following oxidative damage to lipids [catalytic activity: an epoxide + H(2)O = a glycol]; epoxide hydrolase EphA 4665985 ephA 4550909 ephA Mycobacterium ulcerans Agy99 epoxide hydrolase EphA YP_907699.1 4665017 D 362242 CDS YP_907700.1 118619368 4550910 4665979..4667661 1 NC_008611.1 potential pseudogene as C-term extension caused by removal of stop codon and additional 170 aa added.; cytoplasmic protein; monooxygenase 4667661 4550910 MUL_4194 Mycobacterium ulcerans Agy99 monooxygenase YP_907700.1 4665979 D 362242 CDS YP_907701.1 118619369 4550911 complement(4667212..4668468) 1 NC_008611.1 PPE65; membrane protein; PPE family protein 4668468 4550911 MUL_4195 Mycobacterium ulcerans Agy99 PPE family protein YP_907701.1 4667212 R 362242 CDS YP_907702.1 118619370 4550912 complement(4668481..4668780) 1 NC_008611.1 PE32; membrane protein; PE family protein 4668780 4550912 MUL_4196 Mycobacterium ulcerans Agy99 PE family protein YP_907702.1 4668481 R 362242 CDS YP_907703.1 118619371 4550913 4669091..4670137 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 4670137 4550913 MUL_4197 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_907703.1 4669091 D 362242 CDS YP_907704.1 118619372 4550914 4670831..4671577 1 NC_008611.1 membrane protein; lipoprotein LpqG 4671577 lpqG 4550914 lpqG Mycobacterium ulcerans Agy99 lipoprotein LpqG YP_907704.1 4670831 D 362242 CDS YP_907705.1 118619373 4550915 complement(4671603..4672211) 1 NC_008611.1 cytoplasmic protein; involved in purine salvage [catalytic activity: imp + pyrophosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate (guanine can replace hypoxanthine to produce GMP)]; hypoxanthine-guanine phosphoribosyltransferase Hpt 4672211 hpt 4550915 hpt Mycobacterium ulcerans Agy99 hypoxanthine-guanine phosphoribosyltransferase Hpt YP_907705.1 4671603 R 362242 CDS YP_907706.1 118619374 4550916 complement(4672265..4673236) 1 NC_008611.1 cytoplasmic protein; predicted ATPase of the PP-loop superfamily implicated in cell cycle control; cell cycle protein MesJ 4673236 mesJ 4550916 mesJ Mycobacterium ulcerans Agy99 cell cycle protein MesJ YP_907706.1 4672265 R 362242 CDS YP_907707.1 118619375 4550917 complement(4673215..4674273) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 4674273 4550917 MUL_4202 Mycobacterium ulcerans Agy99 hypothetical protein YP_907707.1 4673215 R 362242 CDS YP_907708.1 118619376 4550918 complement(4674270..4675655) 1 NC_008611.1 membrane protein; involved in peptidoglycan synthesis (at final stages) hydrolyzes the bound D-alanyl-D-alanine [catalytic activity: D-alanyl-D-alanine + H(2)O = 2 D- alanine]; D-alanyl-D-alanine carboxypeptidase DacB1 4675655 dacB1 4550918 dacB1 Mycobacterium ulcerans Agy99 D-alanyl-D-alanine carboxypeptidase DacB1 YP_907708.1 4674270 R 362242 CDS YP_907709.1 118619377 4550919 4675796..4676284 1 NC_008611.1 Also detected in the extracellular matrix by proteomics.; cytoplasmic protein; involved in the function of cellular bioenergetics [catalytic activity: pyrophosphate + H(2)O = 2 orthophosphate]; inorganic pyrophosphatase Ppa 4676284 ppa 4550919 ppa Mycobacterium ulcerans Agy99 inorganic pyrophosphatase Ppa YP_907709.1 4675796 D 362242 CDS YP_907710.1 118619378 4550920 complement(4676293..4677369) 1 NC_008611.1 membrane protein; hypothetical protein 4677369 4550920 MUL_4205 Mycobacterium ulcerans Agy99 hypothetical protein YP_907710.1 4676293 R 362242 CDS YP_907711.1 118619379 4550921 complement(4677492..4678826) 1 NC_008611.1 cytoplasmic protein; required for the transposition of the insertion element IS2606.; transposase for IS2606 4678826 4550921 MUL_4206 Mycobacterium ulcerans Agy99 transposase for IS2606 YP_907711.1 4677492 R 362242 CDS YP_907712.1 118619380 4550922 4679046..4680254 1 NC_008611.1 membrane protein; hypothetical protein 4680254 4550922 MUL_4207 Mycobacterium ulcerans Agy99 hypothetical protein YP_907712.1 4679046 D 362242 CDS YP_907713.1 118619381 4550923 4680290..4681003 1 NC_008611.1 cytoplasmic protein; function unknown, the domain detected in this CDS is found in a diverse family of glycosyl transferases that transfer the sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.; glycosyl transferase 4681003 4550923 MUL_4208 Mycobacterium ulcerans Agy99 glycosyl transferase YP_907713.1 4680290 D 362242 CDS YP_907714.1 118619382 4550924 4681000..4681341 1 NC_008611.1 membrane protein; hypothetical protein 4681341 4550924 MUL_4209 Mycobacterium ulcerans Agy99 hypothetical protein YP_907714.1 4681000 D 362242 CDS YP_907715.1 118619383 4550925 complement(4681357..4682301) 1 NC_008611.1 cytoplasmic protein; involved in galactofuranosyl biosynthesis: converts UDO-GlcP to UDP-GalP [catalytic activity: UDP- glucopyranose = UDP-galactopyranose]; UDP-glucose 4-epimerase GalE1 4682301 galE1 4550925 galE1 Mycobacterium ulcerans Agy99 UDP-glucose 4-epimerase GalE1 YP_907715.1 4681357 R 362242 CDS YP_907716.1 118619384 4550926 4682334..4684118 1 NC_008611.1 membrane protein; hypothetical protein 4684118 4550926 MUL_4211 Mycobacterium ulcerans Agy99 hypothetical protein YP_907716.1 4682334 D 362242 CDS YP_907717.1 118619385 4551224 complement(4686563..4687474) 1 NC_008611.1 cytoplasmic protein; hydrolase 4687474 4551224 MUL_4213 Mycobacterium ulcerans Agy99 hydrolase YP_907717.1 4686563 R 362242 CDS YP_907718.1 118619386 4551225 4687699..4689033 1 NC_008611.1 cytoplasmic protein; required for the transposition of the insertion element IS2606.; transposase for IS2606 4689033 4551225 MUL_4214 Mycobacterium ulcerans Agy99 transposase for IS2606 YP_907718.1 4687699 D 362242 CDS YP_907719.1 118619387 4551227 complement(4689608..4689850) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 4689850 4551227 MUL_4216 Mycobacterium ulcerans Agy99 hypothetical protein YP_907719.1 4689608 R 362242 CDS YP_907720.1 118619388 4551228 complement(4690163..4690417) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 4690417 4551228 MUL_4217 Mycobacterium ulcerans Agy99 hypothetical protein YP_907720.1 4690163 R 362242 CDS YP_907721.1 118619389 4551229 4690573..4690728 1 NC_008611.1 cytoplasmic protein; hypothetical protein 4690728 4551229 MUL_4218 Mycobacterium ulcerans Agy99 hypothetical protein YP_907721.1 4690573 D 362242 CDS YP_907722.1 118619390 4551231 complement(4690966..4692171) 1 NC_008611.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA; DNA polymerase III subunit delta' 4692171 4551231 MUL_4220 Mycobacterium ulcerans Agy99 DNA polymerase III subunit delta' YP_907722.1 4690966 R 362242 CDS YP_907723.1 118619391 4551232 4692327..4693916 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; C-term contains an adenylyl/guanylyl cyclase domain. may catalyze the formation of cyclic AMP/GMP from ATP/GTP.; adenylate cyclase 4693916 4551232 MUL_4221 Mycobacterium ulcerans Agy99 adenylate cyclase YP_907723.1 4692327 D 362242 CDS YP_907724.1 118619392 4551233 complement(4693927..4696731) 1 NC_008611.1 catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity; DNA topoisomerase I 4696731 topA 4551233 topA Mycobacterium ulcerans Agy99 DNA topoisomerase I YP_907724.1 4693927 R 362242 CDS YP_907725.1 118619393 4551234 complement(4696935..4697513) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 4697513 4551234 MUL_4223 Mycobacterium ulcerans Agy99 hypothetical protein YP_907725.1 4696935 R 362242 CDS YP_907726.1 118619394 4551235 complement(4697658..4697861) 1 NC_008611.1 Detected in the cytoplamic and the secreted fractions by proteomics.; cytoplasmic protein; possibly involved in cold acclimatization processes (the production of the protein is supposed predominantly induced at low temperatures); cold shock protein A CspA_1 4697861 cspA_1 4551235 cspA_1 Mycobacterium ulcerans Agy99 cold shock protein A CspA_1 YP_907726.1 4697658 R 362242 CDS YP_907727.1 118619395 4551237 4700882..4701913 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; hypothetical protein 4701913 4551237 MUL_4226 Mycobacterium ulcerans Agy99 hypothetical protein YP_907727.1 4700882 D 362242 CDS YP_907728.1 118619396 4551147 complement(4702275..4702541) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 4702541 4551147 MUL_4228 Mycobacterium ulcerans Agy99 hypothetical protein YP_907728.1 4702275 R 362242 CDS YP_907729.1 118619397 4551148 complement(4702598..4702798) 1 NC_008611.1 membrane protein; hypothetical protein 4702798 4551148 MUL_4229 Mycobacterium ulcerans Agy99 hypothetical protein YP_907729.1 4702598 R 362242 CDS YP_907730.1 118619398 4551149 complement(4702823..4703425) 1 NC_008611.1 membrane protein; hypothetical protein 4703425 4551149 MUL_4230 Mycobacterium ulcerans Agy99 hypothetical protein YP_907730.1 4702823 R 362242 CDS YP_907731.1 118619399 4551150 complement(4703459..4704253) 1 NC_008611.1 membrane protein; function unknown, contains domain identity to Flp pilus assembly protein TadB; hypothetical protein 4704253 4551150 MUL_4231 Mycobacterium ulcerans Agy99 hypothetical protein YP_907731.1 4703459 R 362242 CDS YP_907732.1 118619400 4551151 complement(4704250..4705419) 1 NC_008611.1 cytoplasmic protein; function unknown, contains domain identity with Flp pilus assembly protein, ATPase CpaF; hypothetical protein 4705419 4551151 MUL_4232 Mycobacterium ulcerans Agy99 hypothetical protein YP_907732.1 4704250 R 362242 CDS YP_907733.1 118619401 4551152 complement(4705530..4706525) 1 NC_008611.1 cytoplasmic protein; function unknown, has a P-loop containing nucleoside triphosphate hydrolase superfamily domain.; hypothetical protein 4706525 4551152 MUL_4233 Mycobacterium ulcerans Agy99 hypothetical protein YP_907733.1 4705530 R 362242 CDS YP_907734.1 118619402 4551153 4707003..4707860 1 NC_008611.1 membrane protein; phosphoserine + H(2)O <=> serine + phosphate; phosphoserine phosphatase SerB 4707860 serB 4551153 serB Mycobacterium ulcerans Agy99 phosphoserine phosphatase SerB YP_907734.1 4707003 D 362242 CDS YP_907735.1 118619403 4551154 complement(4707986..4708300) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 4708300 4551154 MUL_4235 Mycobacterium ulcerans Agy99 hypothetical protein YP_907735.1 4707986 R 362242 CDS YP_907736.1 118619404 4551155 complement(4708353..4709123) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 4709123 4551155 MUL_4236 Mycobacterium ulcerans Agy99 hypothetical protein YP_907736.1 4708353 R 362242 CDS YP_907737.1 118619405 4551156 complement(4709135..4710790) 1 NC_008611.1 membrane protein; involved in active transport of dipeptides across the membrane (import) responsible for energy coupling to the transport system.; dipeptide-transport ATP-binding protein ABC transporter DppD 4710790 dppD 4551156 dppD Mycobacterium ulcerans Agy99 dipeptide-transport ATP-binding protein ABC transporter DppD YP_907737.1 4709135 R 362242 CDS YP_907738.1 118619406 4551157 complement(4710787..4711650) 1 NC_008611.1 membrane protein; involved in active transport of dipeptide across the membrane (import) responsible for the translocation of the substrate across the membrane.; dipeptide-transport integral membrane protein ABC transporter DppC 4711650 dppC 4551157 dppC Mycobacterium ulcerans Agy99 dipeptide-transport integral membrane protein ABC transporter DppC YP_907738.1 4710787 R 362242 CDS YP_907739.1 118619407 4551158 complement(4711643..4712569) 1 NC_008611.1 membrane protein; involved in active transport of dipeptide across the membrane (import) responsible for the translocation of the substrate across the membrane.; dipeptide-transport integral membrane protein ABC transporter DppB 4712569 dppB 4551158 dppB Mycobacterium ulcerans Agy99 dipeptide-transport integral membrane protein ABC transporter DppB YP_907739.1 4711643 R 362242 CDS YP_907740.1 118619408 4551159 complement(4712571..4714328) 1 NC_008611.1 membrane protein; thought to be involved in active transport of dipeptide across the membrane (import); periplasmic dipeptide-binding lipoprotein DppA 4714328 dppA 4551159 dppA Mycobacterium ulcerans Agy99 periplasmic dipeptide-binding lipoprotein DppA YP_907740.1 4712571 R 362242 CDS YP_907741.1 118619409 4551160 4714374..4716356 1 NC_008611.1 Acs; catalyzes the conversion of acetate and CoA to acetyl-CoA; acetyl-CoA synthetase 4716356 acs 4551160 acs Mycobacterium ulcerans Agy99 acetyl-CoA synthetase YP_907741.1 4714374 D 362242 CDS YP_907742.1 118619410 4551161 complement(4716365..4717063) 1 NC_008611.1 membrane protein; function unknown, domain identity suggests peptidase, trypsin-like serine or cysteine protease. contains peptidase S1B, active site.; hypothetical protein 4717063 4551161 MUL_4242 Mycobacterium ulcerans Agy99 hypothetical protein YP_907742.1 4716365 R 362242 CDS YP_907743.1 118619411 4551162 4717289..4717807 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; hypothetical protein 4717807 4551162 MUL_4243 Mycobacterium ulcerans Agy99 hypothetical protein YP_907743.1 4717289 D 362242 CDS YP_907744.1 118619412 4551163 4717808..4718773 1 NC_008611.1 thought to be involved in detoxification reactions following oxidative damage to lipids. biotransformation enzyme that catalyzes the hydrolysis of epoxides: aromatic hydrocarbons catabolism [catalytic activity: an epoxide + H(2)O = a glycol]; epoxide hydrolase EphE 4718773 ephE 4551163 ephE Mycobacterium ulcerans Agy99 epoxide hydrolase EphE YP_907744.1 4717808 D 362242 CDS YP_907745.1 118619413 4551164 complement(4718766..4719968) 1 NC_008611.1 membrane protein; function unknown, hydrolyses of peptides and/or proteins (possibly cleaved preferentially after serine residue) contains peptidase S1B, active site; membrane-associated serine protease 4719968 4551164 MUL_4245 Mycobacterium ulcerans Agy99 membrane-associated serine protease YP_907745.1 4718766 R 362242 CDS YP_907746.1 118619414 4551238 complement(4720778..4721383) 1 NC_008611.1 membrane protein; function unknown, contains a N-term thioredoxin domain. may serve as a general protein disulphide oxidoreductase.; membrane-anchored thioredoxin-like protein 4721383 4551238 MUL_4247 Mycobacterium ulcerans Agy99 membrane-anchored thioredoxin-like protein YP_907746.1 4720778 R 362242 CDS YP_907747.1 118619415 4551239 complement(4721442..4722143) 1 NC_008611.1 cytoplasmic protein; has both an apurinic and/or apyrimidinic endonuclease activity and a DNA N-glycosylase activity. incises damaged DNA at cytosines, thymines and guanines. acts on a damaged strand (oxidized pyrimidines), 5' from the damaged site [catalytic activity: endonucleolytic cleavage near apurinic or apyrimidinic sites to products with 5'-phosphate]; endonuclease III Nth 4722143 nth 4551239 nth Mycobacterium ulcerans Agy99 endonuclease III Nth YP_907747.1 4721442 R 362242 CDS YP_907748.1 118619416 4551240 4722311..4722664 1 NC_008611.1 membrane protein; hypothetical protein 4722664 4551240 MUL_4249 Mycobacterium ulcerans Agy99 hypothetical protein YP_907748.1 4722311 D 362242 CDS YP_907749.1 118619417 4551241 4722763..4723437 1 NC_008611.1 Detected in the cytoplasmic and membrane fractions by proteomics.; cytoplasmic protein; involved in transcriptional mechanism.; regulatory protein 4723437 4551241 MUL_4250 Mycobacterium ulcerans Agy99 regulatory protein YP_907749.1 4722763 D 362242 CDS YP_907750.1 118619418 4551242 complement(4723434..4724240) 1 NC_008611.1 cytoplasmic protein; function unknown, probably involved in cellular metabolism.; hypothetical protein 4724240 4551242 MUL_4251 Mycobacterium ulcerans Agy99 hypothetical protein YP_907750.1 4723434 R 362242 CDS YP_907751.1 118619419 4551243 complement(4724246..4724701) 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; function unknown, this endoribonuclease domain is active on single-stranded mRNA and inhibits protein synthesis by cleavage of mRNA.; hypothetical protein 4724701 4551243 MUL_4252 Mycobacterium ulcerans Agy99 hypothetical protein YP_907751.1 4724246 R 362242 CDS YP_907752.1 118619420 4551244 complement(4724723..4724884) 1 NC_008611.1 hypothetical protein 4724884 4551244 MUL_4253 Mycobacterium ulcerans Agy99 hypothetical protein YP_907752.1 4724723 R 362242 CDS YP_907753.1 118619421 4551245 4724961..4725983 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; membrane protein; function unknown, may catalyze the extrusion of undeterminated anions [catalytic activity: ATP + H(2)O + undeterminated anion(in) = ADP + phosphate + undeterminated anion(out)]; anion transporter ATPase 4725983 4551245 MUL_4254 Mycobacterium ulcerans Agy99 anion transporter ATPase YP_907753.1 4724961 D 362242 CDS YP_907754.1 118619422 4551246 4725980..4727140 1 NC_008611.1 membrane protein; anion-transporting ATPase; supposed catalyzes the extrusion of undeterminated anions [catalytic activity: ATP + H(2)O + undeterminated anion(in) = ADP + phosphate + undeterminated anion(out)]; anion transporter ATPase 4727140 4551246 MUL_4255 Mycobacterium ulcerans Agy99 anion transporter ATPase YP_907754.1 4725980 D 362242 CDS YP_907755.1 118619423 4551247 complement(4727288..4727470) 1 NC_008611.1 potential pseudogene as N-term truncated due to mutation of original start codon; cytoplasmic protein; involved in a transcriptional mechanism.; transcriptional regulatory protein Whib-like WhiB4 4727470 whiB4 4551247 whiB4 Mycobacterium ulcerans Agy99 transcriptional regulatory protein Whib-like WhiB4 YP_907755.1 4727288 R 362242 CDS YP_907756.1 118619424 4551248 4727999..4730410 1 NC_008611.1 membrane protein; involved in peptidoglycan synthesis (at the final stages), cell wall formation. synthesis of cross-linked peptidoglycan from the lipid intermediates. the enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits); bifunctional membrane-associated penicillin- binding protein 1A/1B PonA2 4730410 ponA2 4551248 ponA2 Mycobacterium ulcerans Agy99 bifunctional membrane-associated penicillin- binding protein 1A/1B PonA2 YP_907756.1 4727999 D 362242 CDS YP_907757.1 118619425 4551249 4730488..4731501 1 NC_008611.1 Detected in the cytoplasmic and membrane fractions by proteomics; membrane protein; function unknown, contains metallophosphoesterase domain; hypothetical protein 4731501 4551249 MUL_4258 Mycobacterium ulcerans Agy99 hypothetical protein YP_907757.1 4730488 D 362242 CDS YP_907758.1 118619426 4551250 4731498..4732604 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; function unknown, probably involved in cellular metabolism. reaction catalysed: O(3)-acetyl-L-serine + H(2)S <=> L-cysteine + acetate.; cysteine synthase CysK 4732604 cysK 4551250 cysK Mycobacterium ulcerans Agy99 cysteine synthase CysK YP_907758.1 4731498 D 362242 CDS YP_907759.1 118619427 4551252 complement(4732775..4733026) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 4733026 4551252 MUL_4261 Mycobacterium ulcerans Agy99 hypothetical protein YP_907759.1 4732775 R 362242 CDS YP_907760.1 118619428 4551254 complement(4734598..4734840) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 4734840 4551254 MUL_4263 Mycobacterium ulcerans Agy99 hypothetical protein YP_907760.1 4734598 R 362242 CDS YP_907761.1 118619429 4551255 complement(4734932..4735192) 1 NC_008611.1 membrane protein; hypothetical protein 4735192 4551255 MUL_4264 Mycobacterium ulcerans Agy99 hypothetical protein YP_907761.1 4734932 R 362242 CDS YP_907762.1 118619430 4551115 4740967..4741938 1 NC_008611.1 membrane protein; NrfD is an integral transmembrane protein with loops in both the periplasm and the cytoplasm. NrfD is thought to participate in the transfer of electrons, from the quinone pool into the terminal components of the Nrf pathway.; formate-dependent nitrite reductase, membrane component, NrfD 4741938 nrfD 4551115 nrfD Mycobacterium ulcerans Agy99 formate-dependent nitrite reductase, membrane component, NrfD YP_907762.1 4740967 D 362242 CDS YP_907763.1 118619431 4551116 complement(4741949..4742368) 1 NC_008611.1 cytoplasmic protein; function unknown, contains GatB/Yqey domain. this domain is found at the C terminus of GatB which transamidates glu-tRNA to Gln-tRNA.; hypothetical protein 4742368 4551116 MUL_4271 Mycobacterium ulcerans Agy99 hypothetical protein YP_907763.1 4741949 R 362242 CDS YP_907764.1 118619432 4551117 4742531..4743790 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; hypothetical protein 4743790 4551117 MUL_4272 Mycobacterium ulcerans Agy99 hypothetical protein YP_907764.1 4742531 D 362242 CDS YP_907765.1 118619433 4551118 4743811..4744461 1 NC_008611.1 cytoplasmic protein; hypothetical protein 4744461 4551118 MUL_4273 Mycobacterium ulcerans Agy99 hypothetical protein YP_907765.1 4743811 D 362242 CDS YP_907766.1 118619434 4551119 4744461..4745600 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; hypothetical protein 4745600 4551119 MUL_4274 Mycobacterium ulcerans Agy99 hypothetical protein YP_907766.1 4744461 D 362242 CDS YP_907767.1 118619435 4551120 4745597..4746574 1 NC_008611.1 Detected in the cytoplasmic fraction by LC-MS/MS. Also detected in the extracellular matrix and membrane fraction by proteomics.; cytoplasmic protein; involved in transcriptional mechanism; regulates methanol dehydrogenase.; methanol dehydrogenase transcriptional regulatory protein MoxR2 4746574 moxR2 4551120 moxR2 Mycobacterium ulcerans Agy99 methanol dehydrogenase transcriptional regulatory protein MoxR2 YP_907767.1 4745597 D 362242 CDS YP_907768.1 118619436 4551121 4746574..4747896 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; membrane protein; function unknown, contains N-term signal peptide; hypothetical protein 4747896 4551121 MUL_4276 Mycobacterium ulcerans Agy99 hypothetical protein YP_907768.1 4746574 D 362242 CDS YP_907769.1 118619437 4551122 complement(4747901..4748893) 1 NC_008611.1 membrane protein; hypothetical protein 4748893 4551122 MUL_4277 Mycobacterium ulcerans Agy99 hypothetical protein YP_907769.1 4747901 R 362242 CDS YP_907770.1 118619438 4551123 4748998..4749903 1 NC_008611.1 membrane protein; function unknown, contains RDD domain RDD family. the molecular function of this region is unknown. however this region may be involved in transport of an as yet unknown set of ligands.; hypothetical protein 4749903 4551123 MUL_4278 Mycobacterium ulcerans Agy99 hypothetical protein YP_907770.1 4748998 D 362242 CDS YP_907771.1 118619439 4551124 4749974..4750741 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; PadR-like transcriptional regulatory protein 4750741 4551124 MUL_4279 Mycobacterium ulcerans Agy99 PadR-like transcriptional regulatory protein YP_907771.1 4749974 D 362242 CDS YP_907772.1 118619440 4551125 4750900..4753086 1 NC_008611.1 PE_PGRS9_2; membrane protein; PE-PGRS family protein 4753086 4551125 MUL_4280 Mycobacterium ulcerans Agy99 PE-PGRS family protein YP_907772.1 4750900 D 362242 CDS YP_907773.1 118619441 4551126 complement(4753083..4754609) 1 NC_008611.1 Converts glycerol and ADP to glycerol-3-phosphate and ADP; glycerol kinase 4754609 glpK 4551126 glpK Mycobacterium ulcerans Agy99 glycerol kinase YP_907773.1 4753083 R 362242 CDS YP_907774.1 118619442 4551094 complement(4756949..4758100) 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; probable role in the metabolism of proteins containing the rare amino acid selenocysteine; selenocysteine lyase, CsdB 4758100 csdB 4551094 csdB Mycobacterium ulcerans Agy99 selenocysteine lyase, CsdB YP_907774.1 4756949 R 362242 CDS YP_907775.1 118619443 4551095 complement(4758097..4759062) 1 NC_008611.1 cytoplasmic protein; S-adenosyl-L-methionine- dependentmethyltransferase 4759062 4551095 MUL_4285 Mycobacterium ulcerans Agy99 S-adenosyl-L-methionine- dependentmethyltransferase YP_907775.1 4758097 R 362242 CDS YP_907776.1 118619444 4551096 complement(4759059..4759772) 1 NC_008611.1 cytoplasmic protein; function unknown, contains N-terminal nucleophile aminohydrolase superfamily domain; hypothetical protein 4759772 4551096 MUL_4286 Mycobacterium ulcerans Agy99 hypothetical protein YP_907776.1 4759059 R 362242 CDS YP_907777.1 118619445 4551097 complement(4759772..4761073) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 4761073 4551097 MUL_4287 Mycobacterium ulcerans Agy99 hypothetical protein YP_907777.1 4759772 R 362242 CDS YP_907778.1 118619446 4551099 complement(4762505..4763203) 1 NC_008611.1 secreted protein; hypothetical protein 4763203 4551099 MUL_4290 Mycobacterium ulcerans Agy99 hypothetical protein YP_907778.1 4762505 R 362242 CDS YP_907779.1 118619447 4551100 complement(4763200..4764648) 1 NC_008611.1 Also detected in the membrane fraction by proteomics (LC-MS/MS); cytoplasmic protein; protects against oxidative stress. converts hydrogen peroxide to water and molecular oxygen.; catalase KatE 4764648 katE 4551100 katE Mycobacterium ulcerans Agy99 catalase KatE YP_907779.1 4763200 R 362242 CDS YP_907780.1 118619448 4551101 complement(4764793..4765167) 1 NC_008611.1 cytoplasmic protein; function unknown, rich in short repeat motifs.; hypothetical protein 4765167 4551101 MUL_4292 Mycobacterium ulcerans Agy99 hypothetical protein YP_907780.1 4764793 R 362242 CDS YP_907781.1 118619449 4551102 complement(4765358..4765705) 1 NC_008611.1 cytoplasmic protein; function unknown, rich in short repeat motifs.; hypothetical protein 4765705 4551102 MUL_4293 Mycobacterium ulcerans Agy99 hypothetical protein YP_907781.1 4765358 R 362242 CDS YP_907782.1 118619450 4551104 complement(4766922..4768058) 1 NC_008611.1 secreted protein; hypothetical protein 4768058 4551104 MUL_4295 Mycobacterium ulcerans Agy99 hypothetical protein YP_907782.1 4766922 R 362242 CDS YP_907783.1 118619451 4551105 complement(4768066..4769124) 1 NC_008611.1 catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde; aspartate-semialdehyde dehydrogenase 4769124 asd 4551105 asd Mycobacterium ulcerans Agy99 aspartate-semialdehyde dehydrogenase YP_907783.1 4768066 R 362242 CDS YP_907784.1 118619452 4551106 complement(4769126..4770391) 1 NC_008611.1 catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP, in Bacillus, lysine sensitive; regulated by response to starvation.; aspartate kinase 4770391 ask 4551106 ask Mycobacterium ulcerans Agy99 aspartate kinase YP_907784.1 4769126 R 362242 CDS YP_907785.1 118619453 4551108 complement(4774356..4776248) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 4776248 4551108 MUL_4299 Mycobacterium ulcerans Agy99 hypothetical protein YP_907785.1 4774356 R 362242 CDS YP_907786.1 118619454 4551109 4776991..4778691 1 NC_008611.1 cytoplasmic protein; involved in leucine biosynthesis (at the first step) catalyzes condensation of acetyl-CoA and 2- oxoisovalerate to form 2-isopropylmalate synthase [catalytic activity: 3-carboxy-3-hydroxy-4- methylpentanoate + CoA = acetyl-CoA + 3-methyl-2- oxobutanoate + H(2)O]; 2-isopropylmalate synthase 4778691 leuA 4551109 leuA Mycobacterium ulcerans Agy99 2-isopropylmalate synthase YP_907786.1 4776991 D 362242 CDS YP_907787.1 118619455 4551304 complement(4778688..4779251) 1 NC_008611.1 cytoplasmic protein; involved in transcriptional mechanism.; DeoR family transcriptional regulator 4779251 4551304 MUL_4301 Mycobacterium ulcerans Agy99 DeoR family transcriptional regulator YP_907787.1 4778688 R 362242 CDS YP_907788.1 118619456 4551305 complement(4779251..4779616) 1 NC_008611.1 membrane protein; function unknown, contains multidrug efflux transporter AcrB transmembrane superfamily domain; hypothetical protein 4779616 4551305 MUL_4302 Mycobacterium ulcerans Agy99 hypothetical protein YP_907788.1 4779251 R 362242 CDS YP_907789.1 118619457 4551306 complement(4779747..4780736) 1 NC_008611.1 3'-5' exonuclease of DNA polymerase III; DNA polymerase III subunit epsilon 4780736 dnaQ 4551306 dnaQ Mycobacterium ulcerans Agy99 DNA polymerase III subunit epsilon YP_907789.1 4779747 R 362242 CDS YP_907790.1 118619458 4551307 4780969..4782123 1 NC_008611.1 membrane protein; possible role in cell wall peptidoglycan biogenesis. contains Mur ligase family catalytic domain. possible UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D- alanine ligase, required for the formation of the UDP- MurNAc-linked pentapeptide by addition of the D-Ala-D-Ala subgroup.; UDP-N-acetylmuramyl tripeptide synthase 4782123 4551307 MUL_4304 Mycobacterium ulcerans Agy99 UDP-N-acetylmuramyl tripeptide synthase YP_907790.1 4780969 D 362242 CDS YP_907791.1 118619459 4551308 4782116..4782823 1 NC_008611.1 cytoplasmic protein; involved in cobalamin biosynthesis. catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic a,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (by similarity); cobyric acid synthase CobQ2 4782823 cobQ2 4551308 cobQ2 Mycobacterium ulcerans Agy99 cobyric acid synthase CobQ2 YP_907791.1 4782116 D 362242 CDS YP_907792.1 118619460 4551309 complement(4782839..4783450) 1 NC_008611.1 involved in a recombinational process of DNA repair, independent of the recBC complex; recombination protein RecR 4783450 recR 4551309 recR Mycobacterium ulcerans Agy99 recombination protein RecR YP_907792.1 4782839 R 362242 CDS YP_907793.1 118619461 4551310 complement(4783462..4783905) 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; hypothetical protein 4783905 4551310 MUL_4307 Mycobacterium ulcerans Agy99 hypothetical protein YP_907793.1 4783462 R 362242 CDS YP_907794.1 118619462 4551311 4784040..4784765 1 NC_008611.1 membrane protein; hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain bacterial cell-wall glycopeptides.; N-acetylmuramoyl-L-alanine amidase 4784765 4551311 MUL_4308 Mycobacterium ulcerans Agy99 N-acetylmuramoyl-L-alanine amidase YP_907794.1 4784040 D 362242 CDS YP_907795.1 118619463 4551312 complement(4784762..4785220) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); cytoplasmic protein; function unknown, contains bet v1-like superfamily domain; hypothetical protein 4785220 4551312 MUL_4309 Mycobacterium ulcerans Agy99 hypothetical protein YP_907795.1 4784762 R 362242 CDS YP_907796.1 118619464 4551313 4785333..4786658 1 NC_008611.1 cytoplasmic protein; dehydrogenase 4786658 4551313 MUL_4310 Mycobacterium ulcerans Agy99 dehydrogenase YP_907796.1 4785333 D 362242 CDS YP_907797.1 118619465 4551315 4787982..4788224 1 NC_008611.1 membrane protein; hypothetical protein 4788224 4551315 MUL_4312 Mycobacterium ulcerans Agy99 hypothetical protein YP_907797.1 4787982 D 362242 CDS YP_907798.1 118619466 4551316 4788221..4788766 1 NC_008611.1 cytoplasmic protein; hypothetical protein 4788766 4551316 MUL_4313 Mycobacterium ulcerans Agy99 hypothetical protein YP_907798.1 4788221 D 362242 CDS YP_907799.1 118619467 4551317 4788763..4789134 1 NC_008611.1 cytoplasmic protein; hypothetical protein 4789134 4551317 MUL_4314 Mycobacterium ulcerans Agy99 hypothetical protein YP_907799.1 4788763 D 362242 CDS YP_907800.1 118619468 4551318 complement(4789288..4791153) 1 NC_008611.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA; DNA polymerase III subunits gamma and tau 4791153 dnaZX 4551318 dnaZX Mycobacterium ulcerans Agy99 DNA polymerase III subunits gamma and tau YP_907800.1 4789288 R 362242 CDS YP_907801.1 118619469 4551319 complement(4791212..4792498) 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS. Also detected in the extracellular matrix and the membrane fractions by proteomics.; cytoplasmic protein; transcriptional regulator 4792498 4551319 MUL_4316 Mycobacterium ulcerans Agy99 transcriptional regulator YP_907801.1 4791212 R 362242 CDS YP_907802.1 118619470 4551321 4792943..4793758 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; hypothetical protein 4793758 4551321 MUL_4318 Mycobacterium ulcerans Agy99 hypothetical protein YP_907802.1 4792943 D 362242 CDS YP_907803.1 118619471 4550279 complement(4793790..4794551) 1 NC_008611.1 Detected in the cytoplasmic fraction by proteomics; cytoplasmic protein; oxidizes fatty acids using specific components [catalytic activity: (3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H(2)O]; enoyl-CoA hydratase, EchA3_1 4794551 echA3_1 4550279 echA3_1 Mycobacterium ulcerans Agy99 enoyl-CoA hydratase, EchA3_1 YP_907803.1 4793790 R 362242 CDS YP_907804.1 118619472 4550280 4794652..4795122 1 NC_008611.1 membrane protein; 19 kDa lipoprotein antigen precursor LpqH-like 4795122 4550280 MUL_4320 Mycobacterium ulcerans Agy99 19 kDa lipoprotein antigen precursor LpqH-like YP_907804.1 4794652 D 362242 CDS YP_907805.1 118619473 4550284 4798616..4799947 1 NC_008611.1 cytoplasmic protein; hypothetical protein 4799947 4550284 MUL_4324 Mycobacterium ulcerans Agy99 hypothetical protein YP_907805.1 4798616 D 362242 CDS YP_907806.1 118619474 4550285 4799944..4801098 1 NC_008611.1 cytoplasmic protein; hypothetical protein 4801098 4550285 MUL_4325 Mycobacterium ulcerans Agy99 hypothetical protein YP_907806.1 4799944 D 362242 CDS YP_907807.1 118619475 4550287 4802348..4803043 1 NC_008611.1 secreted protein; hydrolysis of cutin (a polyester that forms the structure of plant cuticle); cutinase, Cut5 4803043 cut5 4550287 cut5 Mycobacterium ulcerans Agy99 cutinase, Cut5 YP_907807.1 4802348 D 362242 CDS YP_907808.1 118619476 4550288 4803084..4804076 1 NC_008611.1 membrane protein; function unknown, probably involved in cellular metabolism.; oxidoreductase 4804076 4550288 MUL_4328 Mycobacterium ulcerans Agy99 oxidoreductase YP_907808.1 4803084 D 362242 CDS YP_907809.1 118619477 4550289 complement(4804272..4804655) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; hypothetical protein 4804655 4550289 MUL_4330 Mycobacterium ulcerans Agy99 hypothetical protein YP_907809.1 4804272 R 362242 CDS YP_907810.1 118619478 4550291 4808057..4808368 1 NC_008611.1 cytoplasmic protein; hypothetical protein 4808368 4550291 MUL_4332 Mycobacterium ulcerans Agy99 hypothetical protein YP_907810.1 4808057 D 362242 CDS YP_907811.1 118619479 4550292 4808365..4808943 1 NC_008611.1 cytoplasmic protein; hypothetical protein 4808943 4550292 MUL_4333 Mycobacterium ulcerans Agy99 hypothetical protein YP_907811.1 4808365 D 362242 CDS YP_907812.1 118619480 4550294 4812375..4812689 1 NC_008611.1 PE5_1; Detected in the membrane fraction by proteomics.; membrane protein; PE family protein 4812689 4550294 MUL_4336 Mycobacterium ulcerans Agy99 PE family protein YP_907812.1 4812375 D 362242 CDS YP_907813.1 118619481 4550296 complement(4813978..4814388) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 4814388 4550296 MUL_4338 Mycobacterium ulcerans Agy99 hypothetical protein YP_907813.1 4813978 R 362242 CDS YP_907814.1 118619482 4550297 complement(4814427..4815467) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 4815467 4550297 MUL_4339 Mycobacterium ulcerans Agy99 hypothetical protein YP_907814.1 4814427 R 362242 CDS YP_907815.1 118619483 4550500 4815505..4816581 1 NC_008611.1 catalyzes the ATP-dependent formation of a phosphodiester at the site of a single-strand break in duplex DNA; in mycobacteria LigC has weak intrinsic nick joining activities and is not essential for growth; ATP-dependent DNA ligase 4816581 ligC 4550500 ligC Mycobacterium ulcerans Agy99 ATP-dependent DNA ligase YP_907815.1 4815505 D 362242 CDS YP_907816.1 118619484 4550501 4816680..4817222 1 NC_008611.1 cytoplasmic protein; hypothetical protein 4817222 4550501 MUL_4341 Mycobacterium ulcerans Agy99 hypothetical protein YP_907816.1 4816680 D 362242 CDS YP_907817.1 118619485 4550503 4818580..4819674 1 NC_008611.1 membrane protein; hypothetical protein 4819674 4550503 MUL_4343 Mycobacterium ulcerans Agy99 hypothetical protein YP_907817.1 4818580 D 362242 CDS YP_907818.1 118619486 4550504 complement(4819615..4820043) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 4820043 4550504 MUL_4344 Mycobacterium ulcerans Agy99 hypothetical protein YP_907818.1 4819615 R 362242 CDS YP_907819.1 118619487 4550506 complement(4821484..4822563) 1 NC_008611.1 cytoplasmic protein; function unknown, involved in cellular metabolism; multi-functional enzyme with acyl-CoA-reductase activity AcrA1_1 4822563 acrA1_1 4550506 acrA1_1 Mycobacterium ulcerans Agy99 multi-functional enzyme with acyl-CoA-reductase activity AcrA1_1 YP_907819.1 4821484 R 362242 CDS YP_907820.1 118619488 4550507 4822749..4823555 1 NC_008611.1 cytoplasmic protein; hypothetical protein 4823555 4550507 MUL_4347 Mycobacterium ulcerans Agy99 hypothetical protein YP_907820.1 4822749 D 362242 CDS YP_907821.1 118619489 4550508 4823718..4824110 1 NC_008611.1 membrane protein; hypothetical protein 4824110 4550508 MUL_4348 Mycobacterium ulcerans Agy99 hypothetical protein YP_907821.1 4823718 D 362242 CDS YP_907822.1 118619490 4550509 complement(4824127..4825929) 1 NC_008611.1 cytoplasmic protein; function unknown, but involved in lipid degradation.; long-chain-fatty-acid-CoA ligase FadD15_1 4825929 fadD15_1 4550509 fadD15_1 Mycobacterium ulcerans Agy99 long-chain-fatty-acid-CoA ligase FadD15_1 YP_907822.1 4824127 R 362242 CDS YP_907823.1 118619491 4550510 4826189..4827208 1 NC_008611.1 cytoplasmic protein; involved in transcriptional mechanism.; AraC/XylS family transcriptional regulator 4827208 4550510 MUL_4350 Mycobacterium ulcerans Agy99 AraC/XylS family transcriptional regulator YP_907823.1 4826189 D 362242 CDS YP_907824.1 118619492 4550511 complement(4827300..4828649) 1 NC_008611.1 membrane protein; hypothetical protein 4828649 4550511 MUL_4351 Mycobacterium ulcerans Agy99 hypothetical protein YP_907824.1 4827300 R 362242 CDS YP_907825.1 118619493 4550512 complement(4828702..4830201) 1 NC_008611.1 Detected in the secreted fraction by proteomics.; secreted protein; function unknown role in oxidoreduction; monooxygenase-like flavoprotein 4830201 4550512 MUL_4352 Mycobacterium ulcerans Agy99 monooxygenase-like flavoprotein YP_907825.1 4828702 R 362242 CDS YP_907826.1 118619494 4550513 4830507..4831592 1 NC_008611.1 cytoplasmic protein; hypothetical protein 4831592 4550513 MUL_4353 Mycobacterium ulcerans Agy99 hypothetical protein YP_907826.1 4830507 D 362242 CDS YP_907827.1 118619495 4550514 4831589..4832404 1 NC_008611.1 cytoplasmic protein; short chain dehydrogenase 4832404 4550514 MUL_4354 Mycobacterium ulcerans Agy99 short chain dehydrogenase YP_907827.1 4831589 D 362242 CDS YP_907828.1 118619496 4550515 complement(4832399..4833433) 1 NC_008611.1 cytoplasmic protein; involved at the first committed step in the 'phosphorylated' pathway of L-serine biosynthesis [catalytic activity: 3-phosphoglycerate + NAD(+) = 3- phosphohydroxypyruvate + NADH]; D-3-phosphoglycerate dehydrogenase SerA4 4833433 serA4 4550515 serA4 Mycobacterium ulcerans Agy99 D-3-phosphoglycerate dehydrogenase SerA4 YP_907828.1 4832399 R 362242 CDS YP_907829.1 118619497 4550516 4833556..4837482 1 NC_008611.1 membrane protein; involved in lipid metabolism.; non-ribosomal peptide synthetase 4837482 4550516 MUL_4356 Mycobacterium ulcerans Agy99 non-ribosomal peptide synthetase YP_907829.1 4833556 D 362242 CDS YP_907830.1 118619498 4550517 4837479..4838804 1 NC_008611.1 cytoplasmic protein; aminopeptidase with broad substrate specificity to several peptides (could preferentially cleave leucine, arginine and lysine in peptide-bond-containing substrates); aminopeptidase N PepN_1 4838804 pepN_1 4550517 pepN_1 Mycobacterium ulcerans Agy99 aminopeptidase N PepN_1 YP_907830.1 4837479 D 362242 CDS YP_907831.1 118619499 4550518 complement(4838817..4839203) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 4839203 4550518 MUL_4358 Mycobacterium ulcerans Agy99 hypothetical protein YP_907831.1 4838817 R 362242 CDS YP_907832.1 118619500 4550519 complement(4839268..4839603) 1 NC_008611.1 PE34; membrane protein; PE family protein 4839603 4550519 MUL_4359 Mycobacterium ulcerans Agy99 PE family protein YP_907832.1 4839268 R 362242 CDS YP_907833.1 118619501 4550399 4840149..4840532 1 NC_008611.1 cytoplasmic protein; hypothetical protein 4840532 4550399 MUL_4360 Mycobacterium ulcerans Agy99 hypothetical protein YP_907833.1 4840149 D 362242 CDS YP_907834.1 118619502 4550400 complement(4840662..4841399) 1 NC_008611.1 cytoplasmic protein; function unknown, supposed involvement in cellular metabolism.; short-chain type dehydrogenase/reductase 4841399 4550400 MUL_4361 Mycobacterium ulcerans Agy99 short-chain type dehydrogenase/reductase YP_907834.1 4840662 R 362242 CDS YP_907835.1 118619503 4550401 complement(4841408..4842664) 1 NC_008611.1 cytoplasmic protein; function unknown, probably involved in cellular metabolism.; hydrolase 4842664 4550401 MUL_4362 Mycobacterium ulcerans Agy99 hydrolase YP_907835.1 4841408 R 362242 CDS YP_907836.1 118619504 4550402 complement(4842661..4843932) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 4843932 4550402 MUL_4363 Mycobacterium ulcerans Agy99 hypothetical protein YP_907836.1 4842661 R 362242 CDS YP_907837.1 118619505 4550403 4844061..4844546 1 NC_008611.1 membrane protein; hypothetical protein 4844546 4550403 MUL_4364 Mycobacterium ulcerans Agy99 hypothetical protein YP_907837.1 4844061 D 362242 CDS YP_907838.1 118619506 4550404 4844618..4845001 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; unknwon; hypothetical protein 4845001 4550404 MUL_4365 Mycobacterium ulcerans Agy99 hypothetical protein YP_907838.1 4844618 D 362242 CDS YP_907839.1 118619507 4550405 4845060..4845419 1 NC_008611.1 cytoplasmic protein; hypothetical protein 4845419 4550405 MUL_4366 Mycobacterium ulcerans Agy99 hypothetical protein YP_907839.1 4845060 D 362242 CDS YP_907840.1 118619508 4550406 complement(4845511..4848744) 1 NC_008611.1 membrane protein; PE-PGRS family protein 4848744 4550406 MUL_4367 Mycobacterium ulcerans Agy99 PE-PGRS family protein YP_907840.1 4845511 R 362242 CDS YP_907841.1 118619509 4550407 complement(4848805..4850139) 1 NC_008611.1 cytoplasmic protein; required for the transposition of the insertion element IS2606.; transposase for IS2606 4850139 4550407 MUL_4368 Mycobacterium ulcerans Agy99 transposase for IS2606 YP_907841.1 4848805 R 362242 CDS YP_907842.1 118619510 4550409 complement(4850766..4851224) 1 NC_008611.1 cytoplasmic protein; function unknown, probably involved in deamination of specific substrate.; cytidine/deoxycytidylate deaminase 4851224 4550409 MUL_4370 Mycobacterium ulcerans Agy99 cytidine/deoxycytidylate deaminase YP_907842.1 4850766 R 362242 CDS YP_907843.1 118619511 4550410 complement(4851221..4851742) 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; hypothetical protein 4851742 4550410 MUL_4371 Mycobacterium ulcerans Agy99 hypothetical protein YP_907843.1 4851221 R 362242 CDS YP_907844.1 118619512 4550411 4851874..4852818 1 NC_008611.1 catalyzes the formation of 4-hydroxyphenylpyruvate from prephenate; prephenate dehydrogenase 4852818 tyrA 4550411 tyrA Mycobacterium ulcerans Agy99 prephenate dehydrogenase YP_907844.1 4851874 D 362242 CDS YP_907845.1 118619513 4550412 complement(4852781..4853380) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 4853380 4550412 MUL_4373 Mycobacterium ulcerans Agy99 hypothetical protein YP_907845.1 4852781 R 362242 CDS YP_907846.1 118619514 4550413 complement(4853385..4854131) 1 NC_008611.1 membrane protein; thought to be involved in active transport of osmoprotectant (glycine betaine/carnitine/choline/L- proline) across the membrane (import) responsible for the translocation of the substrate across the membrane.; osmoprotectant (glycine betaine/carnitine/choline/L-proline) transport integral membrane protein ABC transporter ProZ 4854131 proZ 4550413 proZ Mycobacterium ulcerans Agy99 osmoprotectant (glycine betaine/carnitine/choline/L-proline) transport integral membrane protein ABC transporter ProZ YP_907846.1 4853385 R 362242 CDS YP_907847.1 118619515 4550383 complement(4854128..4854808) 1 NC_008611.1 membrane protein; thought to be involved in active transport of osmoprotectant (glycine betaine/carnitine/choline/L- proline) across the membrane (import) responsible for the translocation of the substrate across the membrane.; osmoprotectant (glycine betaine/carnitine/choline/L-proline) transport integral membrane protein ABC transporter ProW 4854808 proW 4550383 proW Mycobacterium ulcerans Agy99 osmoprotectant (glycine betaine/carnitine/choline/L-proline) transport integral membrane protein ABC transporter ProW YP_907847.1 4854128 R 362242 CDS YP_907848.1 118619516 4550385 complement(4855925..4856872) 1 NC_008611.1 secreted protein; thought to be involved in active transport of osmoprotectant (glycine betaine/carnitine/choline/L- proline) across the membrane (import); osmoprotectant (glycine betaine/carnitine/choline/L-proline) binding lipoprotein ProX 4856872 proX 4550385 proX Mycobacterium ulcerans Agy99 osmoprotectant (glycine betaine/carnitine/choline/L-proline) binding lipoprotein ProX YP_907848.1 4855925 R 362242 CDS YP_907849.1 118619517 4550386 4856987..4857364 1 NC_008611.1 membrane protein; hypothetical protein 4857364 4550386 MUL_4378 Mycobacterium ulcerans Agy99 hypothetical protein YP_907849.1 4856987 D 362242 CDS YP_907850.1 118619518 4550388 complement(4858571..4859179) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 4859179 4550388 MUL_4380 Mycobacterium ulcerans Agy99 hypothetical protein YP_907850.1 4858571 R 362242 CDS YP_907851.1 118619519 4550389 4859588..4862377 1 NC_008611.1 secreted protein; PE-PGRS family protein 4862377 4550389 MUL_4381 Mycobacterium ulcerans Agy99 PE-PGRS family protein YP_907851.1 4859588 D 362242 CDS YP_907852.1 118619520 4550391 4863715..4864767 1 NC_008611.1 cytoplasmic protein; hypothetical protein 4864767 4550391 MUL_4383 Mycobacterium ulcerans Agy99 hypothetical protein YP_907852.1 4863715 D 362242 CDS YP_907853.1 118619521 4550392 4864769..4865533 1 NC_008611.1 cytoplasmic protein; function unknown, possibly involved in cellular metabolism.; short-chain type dehydrogenase/reductase 4865533 4550392 MUL_4384 Mycobacterium ulcerans Agy99 short-chain type dehydrogenase/reductase YP_907853.1 4864769 D 362242 CDS YP_907854.1 118619522 4550393 4865551..4866858 1 NC_008611.1 cytoplasmic protein; function unknown, but involved in lipid degradation.; acyl-CoA dehydrogenase FadE1_1 4866858 fadE1_1 4550393 fadE1_1 Mycobacterium ulcerans Agy99 acyl-CoA dehydrogenase FadE1_1 YP_907854.1 4865551 D 362242 CDS YP_907855.1 118619523 4550394 4866855..4867457 1 NC_008611.1 cytoplasmic protein; hypothetical protein 4867457 4550394 MUL_4386 Mycobacterium ulcerans Agy99 hypothetical protein YP_907855.1 4866855 D 362242 CDS YP_907856.1 118619524 4550395 4867458..4868426 1 NC_008611.1 membrane protein; possibly binds NADP and acts through a one-electron transfer process. quinones are supposed to be the best substrates. may act in the detoxification of xenobiotics [catalytic activity: NADPH + quinone = NADP+ + semiquinone]; quinone oxidoreductase 4868426 4550395 MUL_4387 Mycobacterium ulcerans Agy99 quinone oxidoreductase YP_907856.1 4867458 D 362242 CDS YP_907857.1 118619525 4550396 complement(4868466..4870313) 1 NC_008611.1 cytoplasmic protein; function unknown, probably involved in cellular metabolism.; hydrolase 4870313 4550396 MUL_4388 Mycobacterium ulcerans Agy99 hydrolase YP_907857.1 4868466 R 362242 CDS YP_907858.1 118619526 4550397 4870493..4870978 1 NC_008611.1 secreted protein; 19 kDa lipoprotein antigen precursor LpqH 4870978 lpqH 4550397 lpqH Mycobacterium ulcerans Agy99 19 kDa lipoprotein antigen precursor LpqH YP_907858.1 4870493 D 362242 CDS YP_907859.1 118619527 4550557 complement(4872737..4873441) 1 NC_008611.1 cytoplasmic protein; sensor part of a two component regulatory system.; two component transcriptional regulatory protein TcrX 4873441 tcrX 4550557 tcrX Mycobacterium ulcerans Agy99 two component transcriptional regulatory protein TcrX YP_907859.1 4872737 R 362242 CDS YP_907860.1 118619528 4550558 4873519..4874853 1 NC_008611.1 cytoplasmic protein; required for the transposition of the insertion element IS2606.; transposase for IS2606 4874853 4550558 MUL_4392 Mycobacterium ulcerans Agy99 transposase for IS2606 YP_907860.1 4873519 D 362242 CDS YP_907861.1 118619529 4550560 complement(4876384..4876539) 1 NC_008611.1 membrane protein; hypothetical protein 4876539 4550560 MUL_4394 Mycobacterium ulcerans Agy99 hypothetical protein YP_907861.1 4876384 R 362242 CDS YP_907862.1 118619530 4550563 complement(4877141..4878475) 1 NC_008611.1 cytoplasmic protein; required for the transposition of the insertion element IS2606.; transposase for IS2606 4878475 4550563 MUL_4397 Mycobacterium ulcerans Agy99 transposase for IS2606 YP_907862.1 4877141 R 362242 CDS YP_907863.1 118619531 4550564 4878906..4879952 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 4879952 4550564 MUL_4398 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_907863.1 4878906 D 362242 CDS YP_907864.1 118619532 4550565 complement(4880207..4881649) 1 NC_008611.1 membrane protein; PE-PGRS family protein 4881649 4550565 MUL_4399 Mycobacterium ulcerans Agy99 PE-PGRS family protein YP_907864.1 4880207 R 362242 CDS YP_907865.1 118619533 4550566 complement(4881794..4883275) 1 NC_008611.1 membrane protein; PE-PGRS family protein 4883275 4550566 MUL_4400 Mycobacterium ulcerans Agy99 PE-PGRS family protein YP_907865.1 4881794 R 362242 CDS YP_907866.1 118619534 4550567 complement(4883410..4884456) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 4884456 4550567 MUL_4401 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_907866.1 4883410 R 362242 CDS YP_907867.1 118619535 4550568 complement(4884825..4885769) 1 NC_008611.1 cytoplasmic protein; function unknown, may play a role in secondary metabolites biosynthesis, transport, and catabolism.; O-methyltransferase 4885769 4550568 MUL_4402 Mycobacterium ulcerans Agy99 O-methyltransferase YP_907867.1 4884825 R 362242 CDS YP_907868.1 118619536 4550569 4885894..4886241 1 NC_008611.1 cytoplasmic protein; hypothetical protein 4886241 4550569 MUL_4403 Mycobacterium ulcerans Agy99 hypothetical protein YP_907868.1 4885894 D 362242 CDS YP_907869.1 118619537 4549887 4886283..4887275 1 NC_008611.1 cytoplasmic protein; hypothetical protein 4887275 4549887 MUL_4404 Mycobacterium ulcerans Agy99 hypothetical protein YP_907869.1 4886283 D 362242 CDS YP_907870.1 118619538 4549890 4887661..4888746 1 NC_008611.1 cytoplasmic protein; involved in histidine biosynthetic pathway (at the eighth step) [catalytic activity: L-histidinol-phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + glutamate]; putative aminotransferase 4888746 hisC2 4549890 hisC2 Mycobacterium ulcerans Agy99 putative aminotransferase YP_907870.1 4887661 D 362242 CDS YP_907871.1 118619539 4549891 4888743..4889180 1 NC_008611.1 cytoplasmic protein; hypothetical protein 4889180 4549891 MUL_4408 Mycobacterium ulcerans Agy99 hypothetical protein YP_907871.1 4888743 D 362242 CDS YP_907872.1 118619540 4549892 complement(4889228..4889812) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 4889812 4549892 MUL_4409 Mycobacterium ulcerans Agy99 hypothetical protein YP_907872.1 4889228 R 362242 CDS YP_907873.1 118619541 4549893 4889836..4891941 1 NC_008611.1 Point mutation has removed stop codon and translationally coupled EchA21 with LipE; Detected in the cytoplasmic fraction by 2D-LC- MS/MS. Also detected in the membrane fraction by proteomics (2D-LC-MS/MS); cytoplasmic protein; function unknown, lipolytic enzyme probably involved in lipid metabolism.; fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 4891941 4549893 MUL_4410 Mycobacterium ulcerans Agy99 fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE YP_907873.1 4889836 D 362242 CDS YP_907874.1 118619542 4549895 complement(4892343..4893347) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 4893347 4549895 MUL_4412 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_907874.1 4892343 R 362242 CDS YP_907875.1 118619543 4549897 4895350..4895664 1 NC_008611.1 cytoplasmic protein; hypothetical protein 4895664 4549897 MUL_4413 Mycobacterium ulcerans Agy99 hypothetical protein YP_907875.1 4895350 D 362242 CDS YP_907876.1 118619544 4549899 complement(4896524..4897570) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 4897570 4549899 MUL_4415 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_907876.1 4896524 R 362242 CDS YP_907877.1 118619545 4549900 4898115..4899779 1 NC_008611.1 functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family; glucose-6-phosphate isomerase 4899779 pgi 4549900 pgi Mycobacterium ulcerans Agy99 glucose-6-phosphate isomerase YP_907877.1 4898115 D 362242 CDS YP_907878.1 118619546 4549901 complement(4899879..4900628) 1 NC_008611.1 Also detected in the membrane and the cytoplasmic fractions by proteomics; secreted protein; function unknown, possibly involved in cellular metabolism.; short chain dehydrogenase 4900628 4549901 MUL_4417 Mycobacterium ulcerans Agy99 short chain dehydrogenase YP_907878.1 4899879 R 362242 CDS YP_907879.1 118619547 4550209 complement(4900716..4901579) 1 NC_008611.1 Detected in the cytoplamic fraction by LCMSMS; cytoplasmic protein; this enzyme may play a significant role in processes leading to recovery from mutagenesis and/or cell death by alkylating agents [catalytic activity: hydrolysis of DNA containing ring-opened N7-methylguanine residues, releasing 2,6-diamino-4-hydroxy-5-(N- methyl)formamidopyrimide]; formamidopyrimidine-DNA glycosylase 4901579 4550209 MUL_4418 Mycobacterium ulcerans Agy99 formamidopyrimidine-DNA glycosylase YP_907879.1 4900716 R 362242 CDS YP_907880.1 118619548 4550210 complement(4901627..4902679) 1 NC_008611.1 membrane protein; PE-PGRS family protein 4902679 4550210 MUL_4419 Mycobacterium ulcerans Agy99 PE-PGRS family protein YP_907880.1 4901627 R 362242 CDS YP_907881.1 118619549 4550213 complement(4906235..4906978) 1 NC_008611.1 catalyzes the formation of precorrin 6x from precorrin 5; precorrin 6A synthase 4906978 4550213 MUL_4422 Mycobacterium ulcerans Agy99 precorrin 6A synthase YP_907881.1 4906235 R 362242 CDS YP_907882.1 118619550 4550214 4907116..4908039 1 NC_008611.1 membrane protein; hypothetical protein 4908039 4550214 MUL_4424 Mycobacterium ulcerans Agy99 hypothetical protein YP_907882.1 4907116 D 362242 CDS YP_907883.1 118619551 4550215 4908129..4909340 1 NC_008611.1 cytoplasmic protein; function unknown, probably involved in cellular metabolism.; monooxygenase 4909340 4550215 MUL_4425 Mycobacterium ulcerans Agy99 monooxygenase YP_907883.1 4908129 D 362242 CDS YP_907884.1 118619552 4550216 4909897..4910661 1 NC_008611.1 membrane protein; hypothetical protein 4910661 4550216 MUL_4427 Mycobacterium ulcerans Agy99 hypothetical protein YP_907884.1 4909897 D 362242 CDS YP_907885.1 118619553 4550218 complement(4911680..4912471) 1 NC_008611.1 cytoplasmic protein; oxidizes fatty acids using specific components (by similarity) [catalytic activity: (3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H(2)O]; enoyl-CoA hydratase, EchA12_2 4912471 echA12_2 4550218 echA12_2 Mycobacterium ulcerans Agy99 enoyl-CoA hydratase, EchA12_2 YP_907885.1 4911680 R 362242 CDS YP_907886.1 118619554 4550219 4912594..4913517 1 NC_008611.1 cytoplasmic protein; hypothetical protein 4913517 4550219 MUL_4430 Mycobacterium ulcerans Agy99 hypothetical protein YP_907886.1 4912594 D 362242 CDS YP_907887.1 118619555 4550220 4913637..4915358 1 NC_008611.1 membrane protein; PE-PGRS family protein 4915358 4550220 MUL_4431 Mycobacterium ulcerans Agy99 PE-PGRS family protein YP_907887.1 4913637 D 362242 CDS YP_907888.1 118619556 4550222 complement(4917308..4919620) 1 NC_008611.1 catalyzes the ATP-dependent formation of a phosphodiester at the site of a single-strand break in duplex DNA and has been shown to have polymerase activity; ATP-dependent DNA ligase 4919620 4550222 MUL_4434 Mycobacterium ulcerans Agy99 ATP-dependent DNA ligase YP_907888.1 4917308 R 362242 CDS YP_907889.1 118619557 4550223 4919643..4920554 1 NC_008611.1 membrane protein; ATP + D-fructose = ADP + D-fructose 6-phosphate; fructokinase, PfkB 4920554 pfkB 4550223 pfkB Mycobacterium ulcerans Agy99 fructokinase, PfkB YP_907889.1 4919643 D 362242 CDS YP_907890.1 118619558 4550224 4920726..4921601 1 NC_008611.1 cytoplasmic protein; hypothetical protein 4921601 4550224 MUL_4436 Mycobacterium ulcerans Agy99 hypothetical protein YP_907890.1 4920726 D 362242 CDS YP_907891.1 118619559 4550225 4921675..4922778 1 NC_008611.1 Detected in the membrane fraction by proteomics.; membrane protein; involved in active transport of inorganic phosphate across the membrane (import) this is one of the proteins required for binding-protein-mediated phosphate transport.; periplasmic phosphate-binding lipoprotein PstS2 4922778 pstS2 4550225 pstS2 Mycobacterium ulcerans Agy99 periplasmic phosphate-binding lipoprotein PstS2 YP_907891.1 4921675 D 362242 CDS YP_907892.1 118619560 4550227 complement(4925201..4926103) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; involved in active transport of inorganic phosphate across the membrane (import); responsible for the translocation of the substrate across the membrane. this is one of the proteins required for binding-protein- mediated phosphate transport.; phosphate-transport integral membrane ABC transporter PstA1 4926103 pstA1 4550227 pstA1 Mycobacterium ulcerans Agy99 phosphate-transport integral membrane ABC transporter PstA1 YP_907892.1 4925201 R 362242 CDS YP_907893.1 118619561 4550228 complement(4926100..4927074) 1 NC_008611.1 membrane protein; involved in active transport of inorganic phosphate across the membrane (import); responsible for the translocation of the substrate across the membrane. this is one of the proteins required for binding-protein- mediated phosphate transport.; phosphate-transport integral membrane ABC transporter PstC2 4927074 pstC2 4550228 pstC2 Mycobacterium ulcerans Agy99 phosphate-transport integral membrane ABC transporter PstC2 YP_907893.1 4926100 R 362242 CDS YP_907894.1 118619562 4550229 complement(4927087..4928199) 1 NC_008611.1 Detected in the membrane and the secreted protein fractions by proteomics.; secreted protein; involved in active transport of inorganic phosphate across the membrane (import) this is one of the proteins required for binding-protein-mediated phosphate transport.; periplasmic phosphate-binding lipoprotein PhoS2 4928199 phoS2 4550229 phoS2 Mycobacterium ulcerans Agy99 periplasmic phosphate-binding lipoprotein PhoS2 YP_907894.1 4927087 R 362242 CDS YP_907895.1 118619563 4550230 4928533..4929324 1 NC_008611.1 cytoplasmic protein; function unknown, possibly involved in cellular metabolism.; short chain dehydrogenase 4929324 4550230 MUL_4442 Mycobacterium ulcerans Agy99 short chain dehydrogenase YP_907895.1 4928533 D 362242 CDS YP_907896.1 118619564 4550232 4930549..4931283 1 NC_008611.1 hypothetical protein 4931283 4550232 MUL_4444 Mycobacterium ulcerans Agy99 hypothetical protein YP_907896.1 4930549 D 362242 CDS YP_907897.1 118619565 4550233 4931363..4932589 1 NC_008611.1 membrane protein; H(+)-stimulated, highly selective, divalent cation uptake system. responsible for the translocation of the divalent metal across the membrane.; manganese transport protein MntH 4932589 mntH 4550233 mntH Mycobacterium ulcerans Agy99 manganese transport protein MntH YP_907897.1 4931363 D 362242 CDS YP_907898.1 118619566 4550234 4932755..4933084 1 NC_008611.1 secreted protein; hypothetical protein 4933084 4550234 MUL_4446 Mycobacterium ulcerans Agy99 hypothetical protein YP_907898.1 4932755 D 362242 CDS YP_907899.1 118619567 4550235 4933201..4934238 1 NC_008611.1 CDS appears to have been formed by a DNA deletion that fused the N-term of a conserved hypothetical protein with the C-term of a putative oxidoreductase (MON4219); cytoplasmic protein; hypothetical protein 4934238 4550235 MUL_4447 Mycobacterium ulcerans Agy99 hypothetical protein YP_907899.1 4933201 D 362242 CDS YP_907900.1 118619568 4550237 complement(4934427..4934579) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 4934579 4550237 MUL_4449 Mycobacterium ulcerans Agy99 hypothetical protein YP_907900.1 4934427 R 362242 CDS YP_907901.1 118619569 4550238 complement(4934757..4935671) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 4935671 4550238 MUL_4450 Mycobacterium ulcerans Agy99 hypothetical protein YP_907901.1 4934757 R 362242 CDS YP_907902.1 118619570 4550239 4935896..4936195 1 NC_008611.1 cytoplasmic protein; hypothetical protein 4936195 4550239 MUL_4451 Mycobacterium ulcerans Agy99 hypothetical protein YP_907902.1 4935896 D 362242 CDS YP_907903.1 118619571 4550241 complement(4938729..4939241) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 4939241 4550241 MUL_4453 Mycobacterium ulcerans Agy99 hypothetical protein YP_907903.1 4938729 R 362242 CDS YP_907904.1 118619572 4550242 4939315..4939896 1 NC_008611.1 cytoplasmic protein; transposition of an insertion sequence. possibly IS200 family.; transposase for unknown insertion sequence 4939896 4550242 MUL_4454 Mycobacterium ulcerans Agy99 transposase for unknown insertion sequence YP_907904.1 4939315 D 362242 CDS YP_907905.1 118619573 4550192 complement(4939739..4940296) 1 NC_008611.1 membrane protein; hypothetical protein 4940296 4550192 MUL_4455 Mycobacterium ulcerans Agy99 hypothetical protein YP_907905.1 4939739 R 362242 CDS YP_907906.1 118619574 4550193 complement(4940510..4941820) 1 NC_008611.1 membrane protein; PPE family protein 4941820 4550193 MUL_4456 Mycobacterium ulcerans Agy99 PPE family protein YP_907906.1 4940510 R 362242 CDS YP_907907.1 118619575 4550194 4942872..4943651 1 NC_008611.1 membrane protein; hypothetical protein 4943651 4550194 MUL_4458 Mycobacterium ulcerans Agy99 hypothetical protein YP_907907.1 4942872 D 362242 CDS YP_907908.1 118619576 4550195 4943924..4944157 1 NC_008611.1 membrane protein; hypothetical protein 4944157 4550195 MUL_4459 Mycobacterium ulcerans Agy99 hypothetical protein YP_907908.1 4943924 D 362242 CDS YP_907909.1 118619577 4550196 4944423..4944887 1 NC_008611.1 cytoplasmic protein; hypothetical protein 4944887 4550196 MUL_4460 Mycobacterium ulcerans Agy99 hypothetical protein YP_907909.1 4944423 D 362242 CDS YP_907910.1 118619578 4550197 4945577..4946380 1 NC_008611.1 membrane protein; hypothetical protein 4946380 4550197 MUL_4461 Mycobacterium ulcerans Agy99 hypothetical protein YP_907910.1 4945577 D 362242 CDS YP_907911.1 118619579 4550198 4946694..4946993 1 NC_008611.1 membrane protein; PE family protein 4946993 4550198 MUL_4462 Mycobacterium ulcerans Agy99 PE family protein YP_907911.1 4946694 D 362242 CDS YP_907912.1 118619580 4550199 4946999..4948270 1 NC_008611.1 membrane protein; function unknown. possibly a protective antigen involved with the early control of infection.; PPE family protein 4948270 4550199 MUL_4463 Mycobacterium ulcerans Agy99 PPE family protein YP_907912.1 4946999 D 362242 CDS YP_907913.1 118619581 4550201 complement(4949701..4951035) 1 NC_008611.1 cytoplasmic protein; required for the transposition of the insertion element IS2606.; transposase for IS2606 4951035 4550201 MUL_4465 Mycobacterium ulcerans Agy99 transposase for IS2606 YP_907913.1 4949701 R 362242 CDS YP_907914.1 118619582 4550204 complement(4955972..4956496) 1 NC_008611.1 cytoplasmic protein; function unknown. seems to be expressed during macrophage infection.; hypothetical protein 4956496 4550204 MUL_4469 Mycobacterium ulcerans Agy99 hypothetical protein YP_907914.1 4955972 R 362242 CDS YP_907915.1 118619583 4550205 complement(4956797..4957978) 1 NC_008611.1 cytoplasmic protein; possibly involved in camp synthesis [catalytic activity: ATP = 3',5'-cyclic AMP + diphosphate]; adenylate cyclase 4957978 4550205 MUL_4470 Mycobacterium ulcerans Agy99 adenylate cyclase YP_907915.1 4956797 R 362242 CDS YP_907916.1 118619584 4550206 4958078..4959565 1 NC_008611.1 cytoplasmic protein; involved in signal transduction (via phosphorylation) thought to be involved in membrane transport. phosphorylates the peptide substrate myelin basic protein (MBP) at serine and threonine residues [catalytic activity: ATP + a protein = ADP + a phosphoprotein]; anchored-membrane serine/threonine-protein kinase PknF 4959565 pknF 4550206 pknF Mycobacterium ulcerans Agy99 anchored-membrane serine/threonine-protein kinase PknF YP_907916.1 4958078 D 362242 CDS YP_907917.1 118619585 4550208 complement(4959831..4960877) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 4960877 4550208 MUL_4473 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_907917.1 4959831 R 362242 CDS YP_907918.1 118619586 4549793 complement(4961281..4962615) 1 NC_008611.1 cytoplasmic protein; required for the transposition of the insertion element IS2606.; transposase for IS2606 4962615 4549793 MUL_4474 Mycobacterium ulcerans Agy99 transposase for IS2606 YP_907918.1 4961281 R 362242 CDS YP_907919.1 118619587 4549796 4963728..4964774 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 4964774 4549796 MUL_4476 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_907919.1 4963728 D 362242 CDS YP_907920.1 118619588 4549797 complement(4965103..4966491) 1 NC_008611.1 catalyzes the hydrolysis of a monocarboxylic acid amid to form a monocarboxylate and ammonia; amidase 4966491 amiB2 4549797 amiB2 Mycobacterium ulcerans Agy99 amidase YP_907920.1 4965103 R 362242 CDS YP_907921.1 118619589 4549798 4966594..4967022 1 NC_008611.1 cytoplasmic protein; Hit-like protein 4967022 4549798 MUL_4479 Mycobacterium ulcerans Agy99 Hit-like protein YP_907921.1 4966594 D 362242 CDS YP_907922.1 118619590 4549799 4967033..4967485 1 NC_008611.1 hypothetical protein 4967485 4549799 MUL_4480 Mycobacterium ulcerans Agy99 hypothetical protein YP_907922.1 4967033 D 362242 CDS YP_907923.1 118619591 4549800 complement(4967494..4968546) 1 NC_008611.1 cytoplasmic protein; monooxygenase 4968546 4549800 MUL_4481 Mycobacterium ulcerans Agy99 monooxygenase YP_907923.1 4967494 R 362242 CDS YP_907924.1 118619592 4549801 complement(4968584..4969720) 1 NC_008611.1 cytoplasmic protein; function unknown, probably involved in cellular metabolism.; hypothetical protein 4969720 4549801 MUL_4482 Mycobacterium ulcerans Agy99 hypothetical protein YP_907924.1 4968584 R 362242 CDS YP_907925.1 118619593 4549802 complement(4969724..4970551) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 4970551 4549802 MUL_4483 Mycobacterium ulcerans Agy99 hypothetical protein YP_907925.1 4969724 R 362242 CDS YP_907926.1 118619594 4549804 4971932..4973299 1 NC_008611.1 cytoplasmic protein; function unknown, probably involved in cellular metabolism; oxidoreductase 4973299 4549804 MUL_4485 Mycobacterium ulcerans Agy99 oxidoreductase YP_907926.1 4971932 D 362242 CDS YP_907927.1 118619595 4549806 4974745..4975326 1 NC_008611.1 cytoplasmic protein; involved in transcriptional mechanism.; transcriptional regulatory protein 4975326 4549806 MUL_4487 Mycobacterium ulcerans Agy99 transcriptional regulatory protein YP_907927.1 4974745 D 362242 CDS YP_907928.1 118619596 4549807 4975841..4977163 1 NC_008611.1 membrane protein; PE-PGRS family protein 4977163 4549807 MUL_4489 Mycobacterium ulcerans Agy99 PE-PGRS family protein YP_907928.1 4975841 D 362242 CDS YP_907929.1 118619597 4549808 complement(4977316..4977537) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 4977537 4549808 MUL_4490 Mycobacterium ulcerans Agy99 hypothetical protein YP_907929.1 4977316 R 362242 CDS YP_907930.1 118619598 4549809 4977801..4978550 1 NC_008611.1 membrane protein; PPE family protein 4978550 4549809 MUL_4491 Mycobacterium ulcerans Agy99 PPE family protein YP_907930.1 4977801 D 362242 CDS YP_907931.1 118619599 4549810 complement(4978641..4979783) 1 NC_008611.1 membrane protein; catalyzes the acylation of the mycaminose sugar during midecamycin biosynthesis; integral membrane acyltransferase 4979783 4549810 MUL_4492 Mycobacterium ulcerans Agy99 integral membrane acyltransferase YP_907931.1 4978641 R 362242 CDS YP_907932.1 118619600 4549921 4981662..4982258 1 NC_008611.1 membrane protein; lipoprotein LprE 4982258 lprE 4549921 lprE Mycobacterium ulcerans Agy99 lipoprotein LprE YP_907932.1 4981662 D 362242 CDS YP_907933.1 118619601 4549922 4982341..4985748 1 NC_008611.1 cytoplasmic protein; hypothetical protein 4985748 4549922 MUL_4495 Mycobacterium ulcerans Agy99 hypothetical protein YP_907933.1 4982341 D 362242 CDS YP_907934.1 118619602 4549924 complement(4986928..4987245) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; C-term transposase for IS2404 4987245 4549924 MUL_4497 Mycobacterium ulcerans Agy99 C-term transposase for IS2404 YP_907934.1 4986928 R 362242 CDS YP_907935.1 118619603 4549925 complement(4987270..4987974) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; N-term transposase for IS2404 4987974 4549925 MUL_4498 Mycobacterium ulcerans Agy99 N-term transposase for IS2404 YP_907935.1 4987270 R 362242 CDS YP_907936.1 118619604 4549926 4989118..4989876 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; hypothetical protein 4989876 4549926 MUL_4499 Mycobacterium ulcerans Agy99 hypothetical protein YP_907936.1 4989118 D 362242 CDS YP_907937.1 118619605 4549927 4990076..4993792 1 NC_008611.1 kgd; produces succinic semialdehyde; part of alternative pathway from alpha-ketoglutarate to succinate; essential for normal growth; alpha-ketoglutarate decarboxylase 4993792 kgd 4549927 kgd Mycobacterium ulcerans Agy99 alpha-ketoglutarate decarboxylase YP_907937.1 4990076 D 362242 CDS YP_907938.1 118619606 4549928 4993949..4994782 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS. Also detected in the membrane fraction by proteomics (LC-MS/MS); cytoplasmic protein; function unknown, supposed involved in cellular metabolism.; short-chain type dehydrogenase/reductase 4994782 4549928 MUL_4501 Mycobacterium ulcerans Agy99 short-chain type dehydrogenase/reductase YP_907938.1 4993949 D 362242 CDS YP_907939.1 118619607 4549929 complement(4994819..4995670) 1 NC_008611.1 secreted protein; lipoprotein LpqZ 4995670 lpqZ 4549929 lpqZ Mycobacterium ulcerans Agy99 lipoprotein LpqZ YP_907939.1 4994819 R 362242 CDS YP_907940.1 118619608 4549930 complement(4995682..4996896) 1 NC_008611.1 membrane protein; catalizes the oxidative decarboxylation of malate into pyruvate, important for a wide range of metabolic pathways [catalytic activity: (S)-malate + NAD(+) = pyruvate + CO(2) + NADH]; [NAD] dependent malate oxidoreductase Mez_1 4996896 mez_1 4549930 mez_1 Mycobacterium ulcerans Agy99 [NAD] dependent malate oxidoreductase Mez_1 YP_907940.1 4995682 R 362242 CDS YP_907941.1 118619609 4549931 complement(4997055..4998044) 1 NC_008611.1 catalyzes the oxidation of malate to oxaloacetate; malate dehydrogenase 4998044 mdh 4549931 mdh Mycobacterium ulcerans Agy99 malate dehydrogenase YP_907941.1 4997055 R 362242 CDS YP_907942.1 118619610 4549933 complement(4998758..4999804) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 4999804 4549933 MUL_4506 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_907942.1 4998758 R 362242 CDS YP_907943.1 118619611 4549934 complement(5000709..5001854) 1 NC_008611.1 cytoplasmic protein; catalyzes oxidation of glucose-6-phosphate to 6- phosphogluconolactone using coenzyme F420 (an *-hydroxy-5- deazaflavin derivative) as the electron acceptor.; F420-dependent glucose-6-phosphate dehydrogenase Fgd2 5001854 fgd2 4549934 fgd2 Mycobacterium ulcerans Agy99 F420-dependent glucose-6-phosphate dehydrogenase Fgd2 YP_907943.1 5000709 R 362242 CDS YP_907944.1 118619612 4549935 complement(5002096..5003541) 1 NC_008611.1 membrane protein; involved in 4-aminobutyrate (GabA) degradation pathway. transporter for GabA. responsible for the translocation of the substrate across the membrane.; GabA permease GabP_1 5003541 gabP_1 4549935 gabP_1 Mycobacterium ulcerans Agy99 GabA permease GabP_1 YP_907944.1 5002096 R 362242 CDS YP_907945.1 118619613 4549936 complement(5003822..5004394) 1 NC_008611.1 membrane protein; hypothetical protein 5004394 4549936 MUL_4509 Mycobacterium ulcerans Agy99 hypothetical protein YP_907945.1 5003822 R 362242 CDS YP_907946.1 118619614 4549903 complement(5005603..5006346) 1 NC_008611.1 membrane protein; involved in active transport of sugar across the membrane (import) responsible for the translocation of the substrate across the membrane.; sugar-transport integral membrane protein ABC transporter SugB 5006346 sugB 4549903 sugB Mycobacterium ulcerans Agy99 sugar-transport integral membrane protein ABC transporter SugB YP_907946.1 5005603 R 362242 CDS YP_907947.1 118619615 4549904 complement(5006343..5007380) 1 NC_008611.1 secreted protein; involved in active transport of sugar across the membrane (import) responsible for the translocation of the substrate across the membrane.; sugar-transport integral membrane protein ABC transporter SugA 5007380 sugA 4549904 sugA Mycobacterium ulcerans Agy99 sugar-transport integral membrane protein ABC transporter SugA YP_907947.1 5006343 R 362242 CDS YP_907948.1 118619616 4549906 5008259..5009665 1 NC_008611.1 membrane protein 5009665 4549906 MUL_4514 Mycobacterium ulcerans Agy99 membrane protein YP_907948.1 5008259 D 362242 CDS YP_907949.1 118619617 4549907 5009717..5010877 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; function unknown: thought to be an ATP-binding protein.; Mrp-related protein Mrp 5010877 mrp 4549907 mrp Mycobacterium ulcerans Agy99 Mrp-related protein Mrp YP_907949.1 5009717 D 362242 CDS YP_907950.1 118619618 4549908 complement(5010893..5011285) 1 NC_008611.1 mediates the export of protein precursors bearing twin-arginine signal peptides; sec-independent translocase 5011285 tatB 4549908 tatB Mycobacterium ulcerans Agy99 sec-independent translocase YP_907950.1 5010893 R 362242 CDS YP_907951.1 118619619 4549909 complement(5011285..5012799) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; possibly hydrolyzes peptides and/or proteins (seems to cleave preferentially after serine residue); serine protease HtrA (DegP protein) 5012799 htrA 4549909 htrA Mycobacterium ulcerans Agy99 serine protease HtrA (DegP protein) YP_907951.1 5011285 R 362242 CDS YP_907952.1 118619620 4549910 complement(5012971..5013375) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 5013375 4549910 MUL_4518 Mycobacterium ulcerans Agy99 hypothetical protein YP_907952.1 5012971 R 362242 CDS YP_907953.1 118619621 4549911 complement(5013521..5014288) 1 NC_008611.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; in M. tuberculosis this protein is involved in heat shock, oxidative stress and virulence; RNA polymerase sigma factor SigE 5014288 sigE 4549911 sigE Mycobacterium ulcerans Agy99 RNA polymerase sigma factor SigE YP_907953.1 5013521 R 362242 CDS YP_907954.1 118619622 4549912 5014511..5015185 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; function unknown, involved in cellular metabolism; methyltransferase 5015185 4549912 MUL_4520 Mycobacterium ulcerans Agy99 methyltransferase YP_907954.1 5014511 D 362242 CDS YP_907955.1 118619623 4549915 5018053..5018727 1 NC_008611.1 membrane protein; integral membrane protein 5018727 4549915 MUL_4523 Mycobacterium ulcerans Agy99 integral membrane protein YP_907955.1 5018053 D 362242 CDS YP_907956.1 118619624 4549916 5018940..5020202 1 NC_008611.1 membrane protein; PE-PGRS family protein 5020202 4549916 MUL_4524 Mycobacterium ulcerans Agy99 PE-PGRS family protein YP_907956.1 5018940 D 362242 CDS YP_907957.1 118619625 4549918 complement(5021850..5023064) 1 NC_008611.1 catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate; glucose-1-phosphate adenylyltransferase 5023064 glgC 4549918 glgC Mycobacterium ulcerans Agy99 glucose-1-phosphate adenylyltransferase YP_907957.1 5021850 R 362242 CDS YP_907958.1 118619626 4549812 complement(5026333..5027379) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 5027379 4549812 MUL_4529 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_907958.1 5026333 R 362242 CDS YP_907959.1 118619627 4549814 complement(5031585..5032919) 1 NC_008611.1 cytoplasmic protein; required for the transposition of the insertion element IS2606.; transposase for IS2606 5032919 4549814 MUL_4531 Mycobacterium ulcerans Agy99 transposase for IS2606 YP_907959.1 5031585 R 362242 CDS YP_907960.1 118619628 4549816 complement(5033771..5034337) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); cytoplasmic protein; hypothetical protein 5034337 4549816 MUL_4533 Mycobacterium ulcerans Agy99 hypothetical protein YP_907960.1 5033771 R 362242 CDS YP_907961.1 118619629 4549817 complement(5034334..5035758) 1 NC_008611.1 cytoplasmic protein; possibly involved in transcriptional mechanism.; transcriptional regulatory protein 5035758 4549817 MUL_4534 Mycobacterium ulcerans Agy99 transcriptional regulatory protein YP_907961.1 5034334 R 362242 CDS YP_907962.1 118619630 4549818 5035933..5036727 1 NC_008611.1 cytoplasmic protein; hypothetical protein 5036727 4549818 MUL_4535 Mycobacterium ulcerans Agy99 hypothetical protein YP_907962.1 5035933 D 362242 CDS YP_907963.1 118619631 4549819 5037035..5038321 1 NC_008611.1 Also detected in the membrane fraction by proteomics (2D-LC-MS/MS); cytoplasmic protein; involved in glyoxylate bypass (at the first step), an alternative to the tricarboxylic acid cycle (in bacteria, plants, and fungi) [catalytic activity: isocitrate = succinate + glyoxylate] involved in the persistence in the host.; isocitrate lyase Icl 5038321 icl 4549819 icl Mycobacterium ulcerans Agy99 isocitrate lyase Icl YP_907963.1 5037035 D 362242 CDS YP_907964.1 118619632 4549820 5038485..5039351 1 NC_008611.1 converts (S)-3-hydroxybutanoyl-CoA to 3-acetoacetyl-CoA; 3-hydroxybutyryl-CoA dehydrogenase 5039351 fadB2 4549820 fadB2 Mycobacterium ulcerans Agy99 3-hydroxybutyryl-CoA dehydrogenase YP_907964.1 5038485 D 362242 CDS YP_907965.1 118619633 4549821 5039487..5040347 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS. Also detected in the membrane fraction by proteomics (LC-MS/MS); cytoplasmic protein; involved in mycolic acid modification or synthesis.; mycolic acid synthase UmaA 5040347 umaA 4549821 umaA Mycobacterium ulcerans Agy99 mycolic acid synthase UmaA YP_907965.1 5039487 D 362242 CDS YP_907966.1 118619634 4549822 complement(5040579..5041442) 1 NC_008611.1 cytoplasmic protein; involved in the mycolic acid modification or synthesis; essential for the cyclopropanation function. required for cording and mycolic acid cyclopropane ring synthesis in the cell wall.; mycolic acid synthase PcaA 5041442 pcaA 4549822 pcaA Mycobacterium ulcerans Agy99 mycolic acid synthase PcaA YP_907966.1 5040579 R 362242 CDS YP_907967.1 118619635 4549823 complement(5041599..5042282) 1 NC_008611.1 cytoplasmic protein; possibly involved in transcriptional mechanism.; TetR family transcriptional regulator 5042282 4549823 MUL_4540 Mycobacterium ulcerans Agy99 TetR family transcriptional regulator YP_907967.1 5041599 R 362242 CDS YP_907968.1 118619636 4549824 5042417..5043778 1 NC_008611.1 membrane protein; transmembrane protein 5043778 4549824 MUL_4541 Mycobacterium ulcerans Agy99 transmembrane protein YP_907968.1 5042417 D 362242 CDS YP_907969.1 118619637 4549825 5043864..5044280 1 NC_008611.1 cytoplasmic protein; possibly involved in transcriptional mechanism.; transcriptional regulatory protein 5044280 4549825 MUL_4542 Mycobacterium ulcerans Agy99 transcriptional regulatory protein YP_907969.1 5043864 D 362242 CDS YP_907970.1 118619638 4549826 5044620..5045240 1 NC_008611.1 Also detected in the cytoplasmic fraction y proteomics; membrane protein; required for extrapulmonary dissemination. mediates adherence to epithelial cells by binding to sulfated glycoconjugates present at the surface of these cells; binds heparin, dextran sulfate, fucoidan and chondroitin sulfate. promotes hemagglutination of erythrocytes of certain host species. induces mycobacterial aggregation.; iron-regulated heparin binding hemagglutinin HbhA 5045240 hbhA 4549826 hbhA Mycobacterium ulcerans Agy99 iron-regulated heparin binding hemagglutinin HbhA YP_907970.1 5044620 D 362242 CDS YP_907971.1 118619639 4549827 5045393..5045680 1 NC_008611.1 membrane protein; transmembrane protein 5045680 4549827 MUL_4544 Mycobacterium ulcerans Agy99 transmembrane protein YP_907971.1 5045393 D 362242 CDS YP_907972.1 118619640 4549828 5045685..5046167 1 NC_008611.1 secreted protein; hypothetical protein 5046167 4549828 MUL_4545 Mycobacterium ulcerans Agy99 hypothetical protein YP_907972.1 5045685 D 362242 CDS YP_907973.1 118619641 4554000 5046167..5046847 1 NC_008611.1 catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate; deoxyribose-phosphate aldolase 5046847 deoC 4554000 deoC Mycobacterium ulcerans Agy99 deoxyribose-phosphate aldolase YP_907973.1 5046167 D 362242 CDS YP_907974.1 118619642 4554001 complement(5046866..5047756) 1 NC_008611.1 Mutation has removed potential u/s start codon; Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; hypothetical protein 5047756 4554001 MUL_4547 Mycobacterium ulcerans Agy99 hypothetical protein YP_907974.1 5046866 R 362242 CDS YP_907975.1 118619643 4554002 complement(5047909..5048751) 1 NC_008611.1 cytoplasmic protein; function unknown, hydrolytic enzyme probably involved in cellular metabolism.; amidohydrolase 5048751 4554002 MUL_4548 Mycobacterium ulcerans Agy99 amidohydrolase YP_907975.1 5047909 R 362242 CDS YP_907976.1 118619644 4554004 complement(5050453..5050977) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 5050977 4554004 MUL_4551 Mycobacterium ulcerans Agy99 hypothetical protein YP_907976.1 5050453 R 362242 CDS YP_907977.1 118619645 4554005 5051004..5052104 1 NC_008611.1 catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis; UDP-N-acetylenolpyruvoylglucosamine reductase 5052104 murB 4554005 murB Mycobacterium ulcerans Agy99 UDP-N-acetylenolpyruvoylglucosamine reductase YP_907977.1 5051004 D 362242 CDS YP_907978.1 118619646 4554006 5052114..5053529 1 NC_008611.1 membrane protein; lipoprotein LprQ 5053529 lprQ 4554006 lprQ Mycobacterium ulcerans Agy99 lipoprotein LprQ YP_907978.1 5052114 D 362242 CDS YP_907979.1 118619647 4554007 complement(5053513..5054265) 1 NC_008611.1 cytoplasmic protein; function unknown, possibly involved in cellular metabolism.; short-chain type oxidoreductase 5054265 4554007 MUL_4554 Mycobacterium ulcerans Agy99 short-chain type oxidoreductase YP_907979.1 5053513 R 362242 CDS YP_907980.1 118619648 4554008 5054508..5055743 1 NC_008611.1 cytoplasmic protein; possibly involved in transcriptional mechanism.; transcriptional regulatory protein 5055743 4554008 MUL_4555 Mycobacterium ulcerans Agy99 transcriptional regulatory protein YP_907980.1 5054508 D 362242 CDS YP_907981.1 118619649 4554009 5055764..5057155 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS; cytoplasmic protein; thought to be involved in polyprenolmannose synthesis.; mannosyltransferase 5057155 4554009 MUL_4556 Mycobacterium ulcerans Agy99 mannosyltransferase YP_907981.1 5055764 D 362242 CDS YP_907982.1 118619650 4554010 5057152..5057703 1 NC_008611.1 cytoplasmic protein; hypothetical protein 5057703 4554010 MUL_4557 Mycobacterium ulcerans Agy99 hypothetical protein YP_907982.1 5057152 D 362242 CDS YP_907983.1 118619651 4554011 5057717..5058472 1 NC_008611.1 2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate; phosphoglyceromutase 5058472 gpmA 4554011 gpmA Mycobacterium ulcerans Agy99 phosphoglyceromutase YP_907983.1 5057717 D 362242 CDS YP_907984.1 118619652 4554012 5058614..5059834 1 NC_008611.1 membrane protein; sensor part of a two component regulatory system. probably forms part of a two-component regulatory system SenX3/RegX3; phosphorylates RegX3.; two component sensor histidine kinase SenX3 5059834 senX3 4554012 senX3 Mycobacterium ulcerans Agy99 two component sensor histidine kinase SenX3 YP_907984.1 5058614 D 362242 CDS YP_907985.1 118619653 4554013 5059884..5060567 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; transcriptional regulatory protein part of the two component regulatory system RegX3/SenX3.; two component sensory transduction protein RegX3 5060567 regX3 4554013 regX3 Mycobacterium ulcerans Agy99 two component sensory transduction protein RegX3 YP_907985.1 5059884 D 362242 CDS YP_907986.1 118619654 4554014 complement(5060530..5062431) 1 NC_008611.1 membrane protein; function unknown, probably involved in cellular metabolism.; oxidoreductase GMC-type 5062431 4554014 MUL_4561 Mycobacterium ulcerans Agy99 oxidoreductase GMC-type YP_907986.1 5060530 R 362242 CDS YP_907987.1 118619655 4554015 complement(5062428..5062769) 1 NC_008611.1 membrane protein; hypothetical protein 5062769 4554015 MUL_4562 Mycobacterium ulcerans Agy99 hypothetical protein YP_907987.1 5062428 R 362242 CDS YP_907988.1 118619656 4551451 5063860..5064597 1 NC_008611.1 cytoplasmic protein; involved in transcriptional mechanism.; GntR family transcriptional regulator 5064597 4551451 MUL_4564 Mycobacterium ulcerans Agy99 GntR family transcriptional regulator YP_907988.1 5063860 D 362242 CDS YP_907989.1 118619657 4551452 complement(5064610..5065404) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 5065404 4551452 MUL_4565 Mycobacterium ulcerans Agy99 hypothetical protein YP_907989.1 5064610 R 362242 CDS YP_907990.1 118619658 4551453 5065544..5066578 1 NC_008611.1 cytoplasmic protein; hypothetical protein 5066578 4551453 MUL_4566 Mycobacterium ulcerans Agy99 hypothetical protein YP_907990.1 5065544 D 362242 CDS YP_907991.1 118619659 4551454 5066575..5067639 1 NC_008611.1 Also detected in the cytoplasmic fraction by 2D-LC- MS/MS.; membrane protein; transmembrane protein 5067639 4551454 MUL_4567 Mycobacterium ulcerans Agy99 transmembrane protein YP_907991.1 5066575 D 362242 CDS YP_907992.1 118619660 4551455 5067656..5068498 1 NC_008611.1 cytoplasmic protein; hypothetical protein 5068498 4551455 MUL_4568 Mycobacterium ulcerans Agy99 hypothetical protein YP_907992.1 5067656 D 362242 CDS YP_907993.1 118619661 4551456 5068500..5069345 1 NC_008611.1 cytoplasmic protein; hypothetical protein 5069345 4551456 MUL_4569 Mycobacterium ulcerans Agy99 hypothetical protein YP_907993.1 5068500 D 362242 CDS YP_907994.1 118619662 4551457 5069370..5070254 1 NC_008611.1 catalyzes the formation of L-proline from pyrroline-5-carboxylate; pyrroline-5-carboxylate reductase 5070254 proC 4551457 proC Mycobacterium ulcerans Agy99 pyrroline-5-carboxylate reductase YP_907994.1 5069370 D 362242 CDS YP_907995.1 118619663 4551458 5070396..5070653 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS. Also detected in the membrane fraction by proteomics (LC-MS/MS); cytoplasmic protein; hypothetical protein 5070653 4551458 MUL_4571 Mycobacterium ulcerans Agy99 hypothetical protein YP_907995.1 5070396 D 362242 CDS YP_907996.1 118619664 4551459 5070792..5070893 1 NC_008611.1 cytoplasmic protein; hypothetical protein 5070893 4551459 MUL_4572 Mycobacterium ulcerans Agy99 hypothetical protein YP_907996.1 5070792 D 362242 CDS YP_907997.1 118619665 4551460 5070972..5072105 1 NC_008611.1 cytoplasmic protein; involved in galactose metabolism [catalytic activity: UDP-glucose = UDP-galactose]; UDP-glucose 4-epimerase GalE2 5072105 galE2 4551460 galE2 Mycobacterium ulcerans Agy99 UDP-glucose 4-epimerase GalE2 YP_907997.1 5070972 D 362242 CDS YP_907998.1 118619666 4551461 5072087..5073178 1 NC_008611.1 Detected in the secreted fraction by proteomics.; cytoplasmic protein; hypothetical protein 5073178 4551461 MUL_4574 Mycobacterium ulcerans Agy99 hypothetical protein YP_907998.1 5072087 D 362242 CDS YP_907999.1 118619667 4551462 complement(5073232..5074143) 1 NC_008611.1 cytoplasmic protein; essential for the cyclopropanation function. transfers a methylene group from S-adenosyl-L-methionine to the cis double bond of an unsaturated fatty acid chain resulting in the replacement of the double bond with a methylene bridge. mycolic acids, which represent the major constituent of mycobacterial cell wall complex, act as substrates [catalytic activity: S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L- homocysteine + phospholipid cyclopropane fatty acid]; cyclopropane-fatty-acyl-phospholipid synthase 2 CmaA2 5074143 cmaA2 4551462 cmaA2 Mycobacterium ulcerans Agy99 cyclopropane-fatty-acyl-phospholipid synthase 2 CmaA2 YP_907999.1 5073232 R 362242 CDS YP_908000.1 118619668 4551463 complement(5074166..5074666) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 5074666 4551463 MUL_4576 Mycobacterium ulcerans Agy99 hypothetical protein YP_908000.1 5074166 R 362242 CDS YP_908001.1 118619669 4551464 complement(5074711..5075622) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); cytoplasmic protein; removes a phosphate from phosphoserine [catalytic activity: phosphoserine + H2O = serine + phosphate]; phosphoserine phosphatase SerB1 5075622 serB1 4551464 serB1 Mycobacterium ulcerans Agy99 phosphoserine phosphatase SerB1 YP_908001.1 5074711 R 362242 CDS YP_908002.1 118619670 4551465 5075810..5076412 1 NC_008611.1 cytoplasmic protein; involved in cellular metabolism [catalytic activity: CO + H(2)O + acceptor = CO(2) + reduced acceptor]; carbon monoxyde dehydrogenase (small chain), CoxS_1 5076412 coxS_1 4551465 coxS_1 Mycobacterium ulcerans Agy99 carbon monoxyde dehydrogenase (small chain), CoxS_1 YP_908002.1 5075810 D 362242 CDS YP_908003.1 118619671 4551466 5076416..5077393 1 NC_008611.1 cytoplasmic protein; function unknown, probably involved in cellular metabolism [catalytic activity: CO + H(2)O + acceptor = CO(2) + reduced acceptor]; carbon monoxyde dehydrogenase (medium chain), CoxM_1 5077393 coxM_1 4551466 coxM_1 Mycobacterium ulcerans Agy99 carbon monoxyde dehydrogenase (medium chain), CoxM_1 YP_908003.1 5076416 D 362242 CDS YP_908004.1 118619672 4551467 5077390..5079567 1 NC_008611.1 membrane protein; involved in cellular metabolism [catalytic activity: CO + H(2)O + acceptor = CO(2) + reduced acceptor]; carbon monoxyde dehydrogenase (large chain), CoxL_1 5079567 coxL_1 4551467 coxL_1 Mycobacterium ulcerans Agy99 carbon monoxyde dehydrogenase (large chain), CoxL_1 YP_908004.1 5077390 D 362242 CDS YP_908005.1 118619673 4551468 complement(5079607..5081247) 1 NC_008611.1 membrane protein; PE-PGRS family protein 5081247 4551468 MUL_4581 Mycobacterium ulcerans Agy99 PE-PGRS family protein YP_908005.1 5079607 R 362242 CDS YP_908006.1 118619674 4553067 5081588..5082634 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 5082634 4553067 MUL_4582 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_908006.1 5081588 D 362242 CDS YP_908007.1 118619675 4553069 5082945..5084279 1 NC_008611.1 cytoplasmic protein; required for the transposition of the insertion element IS2606.; transposase for IS2606 5084279 4553069 MUL_4584 Mycobacterium ulcerans Agy99 transposase for IS2606 YP_908007.1 5082945 D 362242 CDS YP_908008.1 118619676 4553070 complement(5084584..5085630) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 5085630 4553070 MUL_4585 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_908008.1 5084584 R 362242 CDS YP_908009.1 118619677 4553071 5086047..5087390 1 NC_008611.1 cytoplasmic protein; required for the transposition of the insertion element IS2606.; transposase for IS2606 5087390 4553071 MUL_4586 Mycobacterium ulcerans Agy99 transposase for IS2606 YP_908009.1 5086047 D 362242 CDS YP_908010.1 118619678 4553072 complement(5087447..5088493) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 5088493 4553072 MUL_4587 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_908010.1 5087447 R 362242 CDS YP_908011.1 118619679 4553074 complement(5089459..5090505) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 5090505 4553074 MUL_4589 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_908011.1 5089459 R 362242 CDS YP_908012.1 118619680 4553075 5090934..5091221 1 NC_008611.1 cytoplasmic protein; hypothetical protein 5091221 4553075 MUL_4590 Mycobacterium ulcerans Agy99 hypothetical protein YP_908012.1 5090934 D 362242 CDS YP_908013.1 118619681 4553076 5091355..5091669 1 NC_008611.1 cytoplasmic protein; hypothetical protein 5091669 4553076 MUL_4591 Mycobacterium ulcerans Agy99 hypothetical protein YP_908013.1 5091355 D 362242 CDS YP_908014.1 118619682 4553077 5091788..5092387 1 NC_008611.1 cytoplasmic protein; hypothetical protein 5092387 4553077 MUL_4592 Mycobacterium ulcerans Agy99 hypothetical protein YP_908014.1 5091788 D 362242 CDS YP_908015.1 118619683 4554528 complement(5094418..5095200) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 5095200 4554528 MUL_4594 Mycobacterium ulcerans Agy99 hypothetical protein YP_908015.1 5094418 R 362242 CDS YP_908016.1 118619684 4554529 complement(5095580..5096626) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 5096626 4554529 MUL_4595 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_908016.1 5095580 R 362242 CDS YP_908017.1 118619685 4554531 5097918..5098187 1 NC_008611.1 cytoplasmic protein; hypothetical protein 5098187 4554531 MUL_4597 Mycobacterium ulcerans Agy99 hypothetical protein YP_908017.1 5097918 D 362242 CDS YP_908018.1 118619686 4554532 5098297..5099718 1 NC_008611.1 catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins; glutamyl-tRNA reductase 5099718 hemA 4554532 hemA Mycobacterium ulcerans Agy99 glutamyl-tRNA reductase YP_908018.1 5098297 D 362242 CDS YP_908019.1 118619687 4554533 5099732..5100676 1 NC_008611.1 transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis; porphobilinogen deaminase 5100676 hemC 4554533 hemC Mycobacterium ulcerans Agy99 porphobilinogen deaminase YP_908019.1 5099732 D 362242 CDS YP_908020.1 118619688 4554534 5100701..5102374 1 NC_008611.1 cytoplasmic protein; possibly involved in the biosynthesis of siroheme and cobalamin [catalytic activity: 2 S-adenosyl-L- methionine + uroporphyrin III = 2 S-adenosyl-L- homocysteine + sirohydrochlorin]; uroporphyrin-III C-methyltransferase HemD 5102374 hemD 4554534 hemD Mycobacterium ulcerans Agy99 uroporphyrin-III C-methyltransferase HemD YP_908020.1 5100701 D 362242 CDS YP_908021.1 118619689 4554535 5102414..5103397 1 NC_008611.1 catalyzes the formation of porphobilinogen from 5-aminolevulinate; delta-aminolevulinic acid dehydratase 5103397 hemB 4554535 hemB Mycobacterium ulcerans Agy99 delta-aminolevulinic acid dehydratase YP_908021.1 5102414 D 362242 CDS YP_908022.1 118619690 4554536 5103409..5103945 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; transmembrane protein 5103945 4554536 MUL_4602 Mycobacterium ulcerans Agy99 transmembrane protein YP_908022.1 5103409 D 362242 CDS YP_908023.1 118619691 4554537 5103942..5104226 1 NC_008611.1 membrane protein; transmembrane protein 5104226 4554537 MUL_4603 Mycobacterium ulcerans Agy99 transmembrane protein YP_908023.1 5103942 D 362242 CDS YP_908024.1 118619692 4554538 complement(5104448..5104561) 1 NC_008611.1 hypothetical protein 5104561 4554538 MUL_4605 Mycobacterium ulcerans Agy99 hypothetical protein YP_908024.1 5104448 R 362242 CDS YP_908025.1 118619693 4554539 5104688..5106022 1 NC_008611.1 cytoplasmic protein; required for the transposition of the insertion element IS2606.; transposase for IS2606 5106022 4554539 MUL_4606 Mycobacterium ulcerans Agy99 transposase for IS2606 YP_908025.1 5104688 D 362242 CDS YP_908026.1 118619694 4554540 5106413..5107459 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 5107459 4554540 MUL_4607 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_908026.1 5106413 D 362242 CDS YP_908027.1 118619695 4552220 5112123..5113169 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 5113169 4552220 MUL_4611 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_908027.1 5112123 D 362242 CDS YP_908028.1 118619696 4552221 complement(5113285..5113521) 1 NC_008611.1 membrane protein; hypothetical protein 5113521 4552221 MUL_4612 Mycobacterium ulcerans Agy99 hypothetical protein YP_908028.1 5113285 R 362242 CDS YP_908029.1 118619697 4552222 5113790..5115124 1 NC_008611.1 cytoplasmic protein; required for the transposition of the insertion element IS2606.; transposase for IS2606 5115124 4552222 MUL_4613 Mycobacterium ulcerans Agy99 transposase for IS2606 YP_908029.1 5113790 D 362242 CDS YP_908030.1 118619698 4552223 5115515..5116561 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 5116561 4552223 MUL_4614 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_908030.1 5115515 D 362242 CDS YP_908031.1 118619699 4552224 5116647..5117168 1 NC_008611.1 membrane protein; hypothetical protein 5117168 4552224 MUL_4615 Mycobacterium ulcerans Agy99 hypothetical protein YP_908031.1 5116647 D 362242 CDS YP_908032.1 118619700 4552225 5117335..5118039 1 NC_008611.1 membrane protein; hypothetical protein 5118039 4552225 MUL_4616 Mycobacterium ulcerans Agy99 hypothetical protein YP_908032.1 5117335 D 362242 CDS YP_908033.1 118619701 4552226 complement(5118178..5119707) 1 NC_008611.1 membrane protein; hypothetical protein 5119707 4552226 MUL_4617 Mycobacterium ulcerans Agy99 hypothetical protein YP_908033.1 5118178 R 362242 CDS YP_908034.1 118619702 4552228 5120301..5121125 1 NC_008611.1 PE8; membrane protein; PE family protein 5121125 4552228 MUL_4620 Mycobacterium ulcerans Agy99 PE family protein YP_908034.1 5120301 D 362242 CDS YP_908035.1 118619703 4552229 5121195..5122367 1 NC_008611.1 PPE15; membrane protein; PPE family protein 5122367 4552229 MUL_4621 Mycobacterium ulcerans Agy99 PPE family protein YP_908035.1 5121195 D 362242 CDS YP_908036.1 118619704 4552230 5122515..5122811 1 NC_008611.1 Detected in the membrane fraction by proteomics (2D- LC-MS/MS); membrane protein; EsaT-6 like protein EsxP 5122811 esxP 4552230 esxP Mycobacterium ulcerans Agy99 EsaT-6 like protein EsxP YP_908036.1 5122515 D 362242 CDS YP_908037.1 118619705 4552231 5122850..5123134 1 NC_008611.1 Also detected in the cytoplasmic fraction by 2D-LC- MS/MS.; membrane protein; EsaT-6 like protein EsxN_2 5123134 esxN_2 4552231 esxN_2 Mycobacterium ulcerans Agy99 EsaT-6 like protein EsxN_2 YP_908037.1 5122850 D 362242 CDS YP_908038.1 118619706 4552232 5123395..5124168 1 NC_008611.1 cytoplasmic protein; sensor part of the two component regulatory system TrcS/TrcR. involved in transcriptional autoactivation: TrcR activates its own expression by interacting with the AT-rich sequence of the TrcR promoter.; two component transcriptional regulator TrcR 5124168 trcR 4552232 trcR Mycobacterium ulcerans Agy99 two component transcriptional regulator TrcR YP_908038.1 5123395 D 362242 CDS YP_908039.1 118619707 4552233 5124218..5125720 1 NC_008611.1 membrane protein; sensor part of the two component regulatory system TrcS/TrcR.; two component sensor histidine kinase TrcS 5125720 trcS 4552233 trcS Mycobacterium ulcerans Agy99 two component sensor histidine kinase TrcS YP_908039.1 5124218 D 362242 CDS YP_908040.1 118619708 4552234 5125800..5126498 1 NC_008611.1 cytoplasmic protein; function unknown, possibly involved in amino acid transport and metabolism.; hydantoin racemase 5126498 4552234 MUL_4626 Mycobacterium ulcerans Agy99 hydantoin racemase YP_908040.1 5125800 D 362242 CDS YP_908041.1 118619709 4552235 complement(5126585..5126878) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 5126878 4552235 MUL_4627 Mycobacterium ulcerans Agy99 hypothetical protein YP_908041.1 5126585 R 362242 CDS YP_908042.1 118619710 4550799 complement(5126982..5127884) 1 NC_008611.1 cytoplasmic protein; function unknown; identity to GppA, exopolyphosphatase [nucleotide transport and metabolism / inorganic ion transport and metabolism]; hypothetical protein 5127884 4550799 MUL_4628 Mycobacterium ulcerans Agy99 hypothetical protein YP_908042.1 5126982 R 362242 CDS YP_908043.1 118619711 4550800 complement(5127945..5128436) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 5128436 4550800 MUL_4629 Mycobacterium ulcerans Agy99 hypothetical protein YP_908043.1 5127945 R 362242 CDS YP_908044.1 118619712 4550801 complement(5128429..5129130) 1 NC_008611.1 membrane protein; hypothetical protein 5129130 4550801 MUL_4630 Mycobacterium ulcerans Agy99 hypothetical protein YP_908044.1 5128429 R 362242 CDS YP_908045.1 118619713 4550802 complement(5129164..5130450) 1 NC_008611.1 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis; phosphopyruvate hydratase 5130450 eno 4550802 eno Mycobacterium ulcerans Agy99 phosphopyruvate hydratase YP_908045.1 5129164 R 362242 CDS YP_908046.1 118619714 4550803 complement(5130531..5131262) 1 NC_008611.1 secreted protein; lipoprotein LpqU 5131262 lpqU 4550803 lpqU Mycobacterium ulcerans Agy99 lipoprotein LpqU YP_908046.1 5130531 R 362242 CDS YP_908047.1 118619715 4550804 complement(5131617..5132717) 1 NC_008611.1 functions in degradation of stringent response intracellular messenger ppGpp; in Escherichia coli this gene is co-transcribed with the toxin/antitoxin genes mazEF; activity of MazG is inhibited by MazEF in vitro; ppGpp inhibits mazEF expression; MazG thus works in limiting the toxic activity of the MazF toxin induced during starvation; MazG also interacts with the GTPase protein Era; nucleoside triphosphate pyrophosphohydrolase 5132717 4550804 MUL_4633 Mycobacterium ulcerans Agy99 nucleoside triphosphate pyrophosphohydrolase YP_908047.1 5131617 R 362242 CDS YP_908048.1 118619716 4550805 complement(5132714..5136382) 1 NC_008611.1 cytoplasmic protein; involved in nucleotide excision repair. necessary for strand-specific repair. a lesion in the template strand blocks the RNA polymerase complex (RNAP) the RNAP- DNA-RNA complex is specifically recognized by TrcF which releases RNAP and the truncated transcript; the TcrF may replace RNAP at the lesion site and then recruit the UvrA/B/C repair system.; transcription-repair coupling factor Mfd (TrcF) 5136382 mfd 4550805 mfd Mycobacterium ulcerans Agy99 transcription-repair coupling factor Mfd (TrcF) YP_908048.1 5132714 R 362242 CDS YP_908049.1 118619717 4550806 complement(5136449..5137042) 1 NC_008611.1 cytoplasmic protein; involved in transcriptional mechanism.; TetR family transcriptional regulator 5137042 4550806 MUL_4635 Mycobacterium ulcerans Agy99 TetR family transcriptional regulator YP_908049.1 5136449 R 362242 CDS YP_908050.1 118619718 4550808 5137519..5138997 1 NC_008611.1 forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis; bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 5138997 glmU 4550808 glmU Mycobacterium ulcerans Agy99 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase YP_908050.1 5137519 D 362242 CDS YP_908051.1 118619719 4550809 5139110..5140090 1 NC_008611.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP; ribose-phosphate pyrophosphokinase 5140090 prsA 4550809 prsA Mycobacterium ulcerans Agy99 ribose-phosphate pyrophosphokinase YP_908051.1 5139110 D 362242 CDS YP_908052.1 118619720 4550810 5140091..5140459 1 NC_008611.1 cytoplasmic protein; arsenate reductase 5140459 4550810 MUL_4639 Mycobacterium ulcerans Agy99 arsenate reductase YP_908052.1 5140091 D 362242 CDS YP_908053.1 118619721 4550811 5140456..5141112 1 NC_008611.1 Also detected in the membrane fraction by proteomics (LC-MS/MS); secreted protein; lipoprotein LpqT 5141112 lpqT 4550811 lpqT Mycobacterium ulcerans Agy99 lipoprotein LpqT YP_908053.1 5140456 D 362242 CDS YP_908054.1 118619722 4550813 complement(5141854..5142900) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 5142900 4550813 MUL_4642 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_908054.1 5141854 R 362242 CDS YP_908055.1 118619723 4550814 5143598..5144242 1 NC_008611.1 the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response; 50S ribosomal protein L25/general stress protein Ctc 5144242 rplY 4550814 rplY Mycobacterium ulcerans Agy99 50S ribosomal protein L25/general stress protein Ctc YP_908055.1 5143598 D 362242 CDS YP_908056.1 118619724 4550815 5144255..5144830 1 NC_008611.1 Enables the recycling of peptidyl-tRNAs produced at termination of translation; peptidyl-tRNA hydrolase 5144830 pth 4550815 pth Mycobacterium ulcerans Agy99 peptidyl-tRNA hydrolase YP_908056.1 5144255 D 362242 CDS YP_908057.1 118619725 4554492 complement(5144844..5145758) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; hypothetical protein 5145758 4554492 MUL_4645 Mycobacterium ulcerans Agy99 hypothetical protein YP_908057.1 5144844 R 362242 CDS YP_908058.1 118619726 4554494 complement(5147613..5149247) 1 NC_008611.1 activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase 5149247 pks16 4554494 pks16 Mycobacterium ulcerans Agy99 long-chain-fatty-acid--CoA ligase YP_908058.1 5147613 R 362242 CDS YP_908059.1 118619727 4554495 complement(5149613..5150536) 1 NC_008611.1 catalyzes the phosphorylation of 4-diphosphocytidyl-2-C-methyl-D-erythritol in the nonmevalonate pathway of isoprenoid biosynthesis; 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase 5150536 ispE 4554495 ispE Mycobacterium ulcerans Agy99 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase YP_908059.1 5149613 R 362242 CDS YP_908060.1 118619728 4554496 complement(5150634..5151458) 1 NC_008611.1 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin; dimethyladenosine transferase 5151458 ksgA 4554496 ksgA Mycobacterium ulcerans Agy99 dimethyladenosine transferase YP_908060.1 5150634 R 362242 CDS YP_908061.1 118619729 4554497 complement(5151563..5152651) 1 NC_008611.1 secreted protein; thought to promote the resuscitation and growth of dormant, nongrowing cell. could also stimulates the growth of several other high G+C Gram+ organisms, E.G. mycobacterium avium, mycobacterium bovis (BCG), mycobacterium kansasii, mycobacterium smegmatis.; resuscitation-promoting factor RpfB 5152651 rpfB 4554497 rpfB Mycobacterium ulcerans Agy99 resuscitation-promoting factor RpfB YP_908061.1 5151563 R 362242 CDS YP_908062.1 118619730 4554498 complement(5152861..5153643) 1 NC_008611.1 membrane protein; DNAse involved in proteins export. this sec- independent pathway is termed tat for twin-arginine translocation system. this system mainly transports proteins with bound cofactors that require folding prior to export (by similarity); deoxyribonuclease TatD 5153643 tatD 4554498 tatD Mycobacterium ulcerans Agy99 deoxyribonuclease TatD YP_908062.1 5152861 R 362242 CDS YP_908063.1 118619731 4554499 5153743..5155299 1 NC_008611.1 methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content; methionyl-tRNA synthetase 5155299 metS 4554499 metS Mycobacterium ulcerans Agy99 methionyl-tRNA synthetase YP_908063.1 5153743 D 362242 CDS YP_908064.1 118619732 4554500 5155583..5156149 1 NC_008611.1 cytoplasmic protein; involved in cysteine biosynthesis [catalytic activity: acetyl-CoA + L-serine = CoA + O-acetyl-L- serine]; serine acetyltransferase CysE_1 5156149 cysE_1 4554500 cysE_1 Mycobacterium ulcerans Agy99 serine acetyltransferase CysE_1 YP_908064.1 5155583 D 362242 CDS YP_908065.1 118619733 4554502 5158419..5159603 1 NC_008611.1 cytoplasmic protein; function unknown, probably involved in cellular metabolism; dehydrogenase 5159603 4554502 MUL_4658 Mycobacterium ulcerans Agy99 dehydrogenase YP_908065.1 5158419 D 362242 CDS YP_908066.1 118619734 4554504 5160569..5161882 1 NC_008611.1 catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine; aminodeoxychorismate synthase component I 5161882 pabD 4554504 pabD Mycobacterium ulcerans Agy99 aminodeoxychorismate synthase component I YP_908066.1 5160569 D 362242 CDS YP_908067.1 118619735 4554506 complement(5163343..5164197) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 5164197 4554506 MUL_4662 Mycobacterium ulcerans Agy99 hypothetical protein YP_908067.1 5163343 R 362242 CDS YP_908068.1 118619736 4554507 5164196..5165779 1 NC_008611.1 membrane protein; hypothetical protein 5165779 4554507 MUL_4663 Mycobacterium ulcerans Agy99 hypothetical protein YP_908068.1 5164196 D 362242 CDS YP_908069.1 118619737 4554508 complement(5165776..5166984) 1 NC_008611.1 catalyzes the degradation of arginine to citruline and ammonia; arginine deiminase 5166984 arcA 4554508 arcA Mycobacterium ulcerans Agy99 arginine deiminase YP_908069.1 5165776 R 362242 CDS YP_908070.1 118619738 4551204 5167043..5167660 1 NC_008611.1 cytoplasmic protein; hypothetical protein 5167660 4551204 MUL_4665 Mycobacterium ulcerans Agy99 hypothetical protein YP_908070.1 5167043 D 362242 CDS YP_908071.1 118619739 4551205 complement(5167686..5168339) 1 NC_008611.1 secreted protein; hypothetical protein 5168339 4551205 MUL_4666 Mycobacterium ulcerans Agy99 hypothetical protein YP_908071.1 5167686 R 362242 CDS YP_908072.1 118619740 4551206 complement(5168367..5169044) 1 NC_008611.1 secreted protein; hypothetical protein 5169044 4551206 MUL_5094 Mycobacterium ulcerans Agy99 hypothetical protein YP_908072.1 5168367 R 362242 CDS YP_908073.1 118619741 4551207 complement(5169116..5170117) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 5170117 4551207 MUL_4667 Mycobacterium ulcerans Agy99 hypothetical protein YP_908073.1 5169116 R 362242 CDS YP_908074.1 118619742 4551208 5170282..5171028 1 NC_008611.1 cytoplasmic protein; thought to cause methylation.; methyltransferase 5171028 4551208 MUL_4668 Mycobacterium ulcerans Agy99 methyltransferase YP_908074.1 5170282 D 362242 CDS YP_908075.1 118619743 4551209 complement(5171064..5171315) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 5171315 4551209 MUL_4669 Mycobacterium ulcerans Agy99 hypothetical protein YP_908075.1 5171064 R 362242 CDS YP_908076.1 118619744 4551210 complement(5171430..5172167) 1 NC_008611.1 membrane protein; hypothetical protein 5172167 4551210 MUL_4670 Mycobacterium ulcerans Agy99 hypothetical protein YP_908076.1 5171430 R 362242 CDS YP_908077.1 118619745 4551211 5172293..5172829 1 NC_008611.1 membrane protein; hypothetical protein 5172829 4551211 MUL_4671 Mycobacterium ulcerans Agy99 hypothetical protein YP_908077.1 5172293 D 362242 CDS YP_908078.1 118619746 4551212 5173146..5174318 1 NC_008611.1 membrane protein; PPE family protein 5174318 4551212 MUL_4672 Mycobacterium ulcerans Agy99 PPE family protein YP_908078.1 5173146 D 362242 CDS YP_908079.1 118619747 4551213 5174543..5175373 1 NC_008611.1 cytoplasmic protein; function unknown, possibly involved in cell envelope biogenesis, outer membrane; teichoic acid biosynthesis protein 5175373 4551213 MUL_4673 Mycobacterium ulcerans Agy99 teichoic acid biosynthesis protein YP_908079.1 5174543 D 362242 CDS YP_908080.1 118619748 4551214 5175390..5176895 1 NC_008611.1 membrane protein; function unknown, possibly involved in lipopolysaccharide synthesis.; hypothetical protein 5176895 4551214 MUL_4674 Mycobacterium ulcerans Agy99 hypothetical protein YP_908080.1 5175390 D 362242 CDS YP_908081.1 118619749 4551215 5176910..5178385 1 NC_008611.1 membrane protein; function unknown, possible membrane protein involved in the export of O-antigen and teichoic acid.; hypothetical protein 5178385 4551215 MUL_4675 Mycobacterium ulcerans Agy99 hypothetical protein YP_908081.1 5176910 D 362242 CDS YP_908082.1 118619750 4551216 5178382..5180373 1 NC_008611.1 cytoplasmic protein; probably involved in cell wall synthesis; glycosyltransferase 5180373 4551216 MUL_4676 Mycobacterium ulcerans Agy99 glycosyltransferase YP_908082.1 5178382 D 362242 CDS YP_908083.1 118619751 4551217 5180370..5181425 1 NC_008611.1 cytoplasmic protein; function unknown, contains RfaG, glycosyltransferase domain. may be involved in cell envelope biogenesis, outer membrane.; hypothetical protein 5181425 4551217 MUL_4677 Mycobacterium ulcerans Agy99 hypothetical protein YP_908083.1 5180370 D 362242 CDS YP_908084.1 118619752 4551218 complement(5181440..5182390) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 5182390 4551218 MUL_4678 Mycobacterium ulcerans Agy99 hypothetical protein YP_908084.1 5181440 R 362242 CDS YP_908085.1 118619753 4551219 complement(5182443..5184404) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; hypothetical protein 5184404 4551219 MUL_4679 Mycobacterium ulcerans Agy99 hypothetical protein YP_908085.1 5182443 R 362242 CDS YP_908086.1 118619754 4551220 5184841..5185800 1 NC_008611.1 cytoplasmic protein; hypothetical protein 5185800 4551220 MUL_4680 Mycobacterium ulcerans Agy99 hypothetical protein YP_908086.1 5184841 D 362242 CDS YP_908087.1 118619755 4551221 complement(5185780..5186577) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 5186577 4551221 MUL_4681 Mycobacterium ulcerans Agy99 hypothetical protein YP_908087.1 5185780 R 362242 CDS YP_908088.1 118619756 4551222 complement(5186678..5187343) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 5187343 4551222 MUL_4682 Mycobacterium ulcerans Agy99 hypothetical protein YP_908088.1 5186678 R 362242 CDS YP_908089.1 118619757 4554370 5187502..5188161 1 NC_008611.1 cytoplasmic protein; function unknown; hydrolytic enzyme probably involved in cellular metabolism.; amidohydrolase 5188161 4554370 MUL_4683 Mycobacterium ulcerans Agy99 amidohydrolase YP_908089.1 5187502 D 362242 CDS YP_908090.1 118619758 4554371 complement(5188238..5188999) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 5188999 4554371 MUL_4684 Mycobacterium ulcerans Agy99 hypothetical protein YP_908090.1 5188238 R 362242 CDS YP_908091.1 118619759 4554373 complement(5190210..5191685) 1 NC_008611.1 membrane protein; hypothetical protein 5191685 4554373 MUL_4686 Mycobacterium ulcerans Agy99 hypothetical protein YP_908091.1 5190210 R 362242 CDS YP_908092.1 118619760 4554375 5193402..5194184 1 NC_008611.1 cytoplasmic protein; hypothetical protein 5194184 4554375 MUL_4688 Mycobacterium ulcerans Agy99 hypothetical protein YP_908092.1 5193402 D 362242 CDS YP_908093.1 118619761 4554377 complement(5194419..5195597) 1 NC_008611.1 membrane protein; hypothetical protein 5195597 4554377 MUL_4690 Mycobacterium ulcerans Agy99 hypothetical protein YP_908093.1 5194419 R 362242 CDS YP_908094.1 118619762 4554378 complement(5195805..5196416) 1 NC_008611.1 cytoplasmic protein; this enzyme acetylates the N-terminal alanine of ribosomal protein S5 [catalytic activity: acetyl-CoA + ribosomal-protein L-alanine = CoA + ribosomal-protein N- acetyl-L-alanine]; ribosomal-protein-alanine acetyltransferase RimJ 5196416 rimJ 4554378 rimJ Mycobacterium ulcerans Agy99 ribosomal-protein-alanine acetyltransferase RimJ YP_908094.1 5195805 R 362242 CDS YP_908095.1 118619763 4554379 complement(5196481..5197770) 1 NC_008611.1 cytoplasmic protein; involved in molybdenum cofactor biosynthesis: involved in the biosynthesis of a demolybdo-cofactor (molybdopterin), necessary for molybdo-enzymes.; molybdopterin biosynthesis protein MoeA1 5197770 moeA1 4554379 moeA1 Mycobacterium ulcerans Agy99 molybdopterin biosynthesis protein MoeA1 YP_908095.1 5196481 R 362242 CDS YP_908096.1 118619764 4554380 complement(5197822..5198739) 1 NC_008611.1 cytoplasmic protein; may play a role in stationary phase survival [catalytic activity: UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose]; UTP--glucose-1-phosphate uridylyltransferase GalU 5198739 galU 4554380 galU Mycobacterium ulcerans Agy99 UTP--glucose-1-phosphate uridylyltransferase GalU YP_908096.1 5197822 R 362242 CDS YP_908097.1 118619765 4554381 5198817..5199410 1 NC_008611.1 cytoplasmic protein; hypothetical protein 5199410 4554381 MUL_4694 Mycobacterium ulcerans Agy99 hypothetical protein YP_908097.1 5198817 D 362242 CDS YP_908098.1 118619766 4554382 5199485..5199820 1 NC_008611.1 cytoplasmic protein; putative serine rich protein 5199820 4554382 MUL_4695 Mycobacterium ulcerans Agy99 putative serine rich protein YP_908098.1 5199485 D 362242 CDS YP_908099.1 118619767 4554383 5199887..5200561 1 NC_008611.1 membrane protein; hypothetical protein 5200561 4554383 MUL_4696 Mycobacterium ulcerans Agy99 hypothetical protein YP_908099.1 5199887 D 362242 CDS YP_908100.1 118619768 4554384 5200638..5201093 1 NC_008611.1 forms homopentamer; channel that opens in response to pressure or hypoosmotic shock; large-conductance mechanosensitive channel 5201093 mscL 4554384 mscL Mycobacterium ulcerans Agy99 large-conductance mechanosensitive channel YP_908100.1 5200638 D 362242 CDS YP_908101.1 118619769 4554385 complement(5201113..5201658) 1 NC_008611.1 Detected in the cytoplasmic and secreted fractions by proteomics.; cytoplasmic protein; thought to be involved in molybdopterin biosynthesis. catalyzes the dehydratation of 4A- hydroxytetrahydropterins [catalytic activity: (6R)-6-(L- erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro -4 A- hydroxypterin = (6R)-6-(L-erythro-1,2- dihydroxypropyl)- 7,8-dihydro-6H-pterin + H(2)O]; pterin-4-alpha-carbinolamine dehydratase MoaB2 5201658 moaB2 4554385 moaB2 Mycobacterium ulcerans Agy99 pterin-4-alpha-carbinolamine dehydratase MoaB2 YP_908101.1 5201113 R 362242 CDS YP_908102.1 118619770 4554386 complement(5201655..5203094) 1 NC_008611.1 Non-secretory protein; membrane protein; function unknown, possibly hydrolyzes peptides and/or proteins (seems to cleave preferentially after serine residues); serine protease PepD 5203094 pepD 4554386 pepD Mycobacterium ulcerans Agy99 serine protease PepD YP_908102.1 5201655 R 362242 CDS YP_908103.1 118619771 4554387 complement(5203195..5204730) 1 NC_008611.1 membrane protein; sensor part of a two component regulatory system (supposed MprAB system); two component sensor kinase MprB 5204730 mprB 4554387 mprB Mycobacterium ulcerans Agy99 two component sensor kinase MprB YP_908103.1 5203195 R 362242 CDS YP_908104.1 118619772 4554298 complement(5204730..5205428) 1 NC_008611.1 cytoplasmic protein; regulator part of a two component regulatory system (supposed MprAB system); two component response transcriptional regulatory protein MprA 5205428 mprA 4554298 mprA Mycobacterium ulcerans Agy99 two component response transcriptional regulatory protein MprA YP_908104.1 5204730 R 362242 CDS YP_908105.1 118619773 4554299 complement(5205695..5205868) 1 NC_008611.1 some L32 proteins have zinc finger motifs consisting of CXXC while others do not; 50S ribosomal protein L32 5205868 rpmF 4554299 rpmF Mycobacterium ulcerans Agy99 50S ribosomal protein L32 YP_908105.1 5205695 R 362242 CDS YP_908106.1 118619774 4554300 5206134..5207846 1 NC_008611.1 cytoplasmic protein; hypothetical protein 5207846 4554300 MUL_4703 Mycobacterium ulcerans Agy99 hypothetical protein YP_908106.1 5206134 D 362242 CDS YP_908107.1 118619775 4554301 5207843..5208991 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; function unknown, but involved in lipid degradation.; acyl-CoA dehydrogenase FadE13 5208991 fadE13 4554301 fadE13 Mycobacterium ulcerans Agy99 acyl-CoA dehydrogenase FadE13 YP_908107.1 5207843 D 362242 CDS YP_908108.1 118619776 4554302 5209035..5210636 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; involved in fatty acid metabolism.; acetyl-/propionyl-CoA carboxylase (beta subunit) AccD2 5210636 accD2 4554302 accD2 Mycobacterium ulcerans Agy99 acetyl-/propionyl-CoA carboxylase (beta subunit) AccD2 YP_908108.1 5209035 D 362242 CDS YP_908109.1 118619777 4554303 5210642..5212624 1 NC_008611.1 Detected in the membrane fraction by proteomics (2D- LC-MS/MS); cytoplasmic protein; this protein carries two functions: biotin carboxyl carrier protein and biotin carboxyltransferase. involved in the first step of long-chain fatty acid synthesis [catalytic activity: ATP + biotin-carboxyl-carrier protein + CO(2) = ADP + phosphate + carboxybiotin-carboxyl-carrier protein]; acetyl-/propionyl-coenzyme a carboxylase alpha chain, AccA2 5212624 accA2 4554303 accA2 Mycobacterium ulcerans Agy99 acetyl-/propionyl-coenzyme a carboxylase alpha chain, AccA2 YP_908109.1 5210642 D 362242 CDS YP_908110.1 118619778 4554304 5212621..5213790 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; function unknown, but involved in lipid metabolism.; acyl-CoA dehydrogenase FadE12 5213790 fadE12 4554304 fadE12 Mycobacterium ulcerans Agy99 acyl-CoA dehydrogenase FadE12 YP_908110.1 5212621 D 362242 CDS YP_908111.1 118619779 4554305 5213801..5214574 1 NC_008611.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 5214574 echA7 4554305 echA7 Mycobacterium ulcerans Agy99 enoyl-CoA hydratase YP_908111.1 5213801 D 362242 CDS YP_908112.1 118619780 4554307 5215037..5215639 1 NC_008611.1 cytoplasmic protein; hypothetical protein 5215639 4554307 MUL_4709 Mycobacterium ulcerans Agy99 hypothetical protein YP_908112.1 5215037 D 362242 CDS YP_908113.1 118619781 4554308 complement(5215667..5217664) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 5217664 4554308 MUL_4710 Mycobacterium ulcerans Agy99 hypothetical protein YP_908113.1 5215667 R 362242 CDS YP_908114.1 118619782 4554309 complement(5217657..5219051) 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; chelation, introducing a magnesium ion into specific substrate.; magnesium chelatase 5219051 4554309 MUL_4711 Mycobacterium ulcerans Agy99 magnesium chelatase YP_908114.1 5217657 R 362242 CDS YP_908115.1 118619783 4554310 complement(5219128..5220699) 1 NC_008611.1 involved in de novo purine biosynthesis; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 5220699 purH 4554310 purH Mycobacterium ulcerans Agy99 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase YP_908115.1 5219128 R 362242 CDS YP_908116.1 118619784 4554311 complement(5220696..5221343) 1 NC_008611.1 glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate; phosphoribosylglycinamide formyltransferase 5221343 purN 4554311 purN Mycobacterium ulcerans Agy99 phosphoribosylglycinamide formyltransferase YP_908116.1 5220696 R 362242 CDS YP_908117.1 118619785 4554312 complement(5221396..5222787) 1 NC_008611.1 membrane protein; integral membrane protein 5222787 4554312 MUL_4714 Mycobacterium ulcerans Agy99 integral membrane protein YP_908117.1 5221396 R 362242 CDS YP_908118.1 118619786 4554313 complement(5222836..5223741) 1 NC_008611.1 membrane protein; transmembrane protein 5223741 4554313 MUL_4715 Mycobacterium ulcerans Agy99 transmembrane protein YP_908118.1 5222836 R 362242 CDS YP_908119.1 118619787 4554315 complement(5224819..5226339) 1 NC_008611.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; acetyl-CoA acetyltransferase 5226339 4554315 MUL_4717 Mycobacterium ulcerans Agy99 acetyl-CoA acetyltransferase YP_908119.1 5224819 R 362242 CDS YP_908120.1 118619788 4551289 complement(5227878..5228780) 1 NC_008611.1 Catalyzes the only substrate-level phosphorylation in the TCA cycle; succinyl-CoA synthetase subunit alpha 5228780 sucD 4551289 sucD Mycobacterium ulcerans Agy99 succinyl-CoA synthetase subunit alpha YP_908120.1 5227878 R 362242 CDS YP_908121.1 118619789 4551290 complement(5228796..5229959) 1 NC_008611.1 catalyzes the interconversion of succinyl-CoA and succinate; succinyl-CoA synthetase subunit beta 5229959 sucC 4551290 sucC Mycobacterium ulcerans Agy99 succinyl-CoA synthetase subunit beta YP_908121.1 5228796 R 362242 CDS YP_908122.1 118619790 4551291 5230235..5231293 1 NC_008611.1 cytoplasmic protein; hypothetical protein 5231293 4551291 MUL_4721 Mycobacterium ulcerans Agy99 hypothetical protein YP_908122.1 5230235 D 362242 CDS YP_908123.1 118619791 4551292 5231297..5231881 1 NC_008611.1 membrane protein; hypothetical protein 5231881 4551292 MUL_4722 Mycobacterium ulcerans Agy99 hypothetical protein YP_908123.1 5231297 D 362242 CDS YP_908124.1 118619792 4551293 complement(5231960..5234269) 1 NC_008611.1 cytoplasmic protein; involved in nucleotide excision repair. has a 3'-5' helicase activity in presence of ATP. preferred substrate being one with both single and double stranded regions of DNA.; ATP-dependent DNA helicase II UvrD1 5234269 uvrD1 4551293 uvrD1 Mycobacterium ulcerans Agy99 ATP-dependent DNA helicase II UvrD1 YP_908124.1 5231960 R 362242 CDS YP_908125.1 118619793 4551295 complement(5234751..5235809) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 5235809 4551295 MUL_4725 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_908125.1 5234751 R 362242 CDS YP_908126.1 118619794 4551297 complement(5237281..5238615) 1 NC_008611.1 cytoplasmic protein; required for the transposition of the insertion element IS2606.; transposase for IS2606 5238615 4551297 MUL_4727 Mycobacterium ulcerans Agy99 transposase for IS2606 YP_908126.1 5237281 R 362242 CDS YP_908127.1 118619795 4551299 complement(5238926..5239972) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 5239972 4551299 MUL_4729 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_908127.1 5238926 R 362242 CDS YP_908128.1 118619796 4551300 complement(5240872..5241495) 1 NC_008611.1 cytoplasmic protein; involved in transcriptional mechanism.; TetR family transcriptional regulator 5241495 4551300 MUL_4731 Mycobacterium ulcerans Agy99 TetR family transcriptional regulator YP_908128.1 5240872 R 362242 CDS YP_908129.1 118619797 4551301 5241471..5241788 1 NC_008611.1 fragment; cytoplasmic protein; hypothetical protein 5241788 4551301 MUL_4732 Mycobacterium ulcerans Agy99 hypothetical protein YP_908129.1 5241471 D 362242 CDS YP_908130.1 118619798 4551302 complement(5241831..5243255) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; the transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane [catalytic activity: NADPH + NAD+ = NADP+ + NADH]; NAD(P) transhydrogenase (subunit beta) PntB 5243255 pntB 4551302 pntB Mycobacterium ulcerans Agy99 NAD(P) transhydrogenase (subunit beta) PntB YP_908130.1 5241831 R 362242 CDS YP_908131.1 118619799 4551303 complement(5243252..5243590) 1 NC_008611.1 membrane protein; the transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane [catalytic activity: NADPH + NAD+ = NADP+ + NADH]; NAD(P) transhydrogenase (subunit alpha) PntAb 5243590 pntAb 4551303 pntAb Mycobacterium ulcerans Agy99 NAD(P) transhydrogenase (subunit alpha) PntAb YP_908131.1 5243252 R 362242 CDS YP_908132.1 118619800 4551322 complement(5243606..5244694) 1 NC_008611.1 Detected in the cytoplasmic and secreted fractions by 2D-LC-MS/MS.; cytoplasmic protein; the transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane [catalytic activity: NADPH + NAD+ = NADP+ + NADH]; NAD(P) transhydrogenase (subunit alpha) PntAa 5244694 pntAa 4551322 pntAa Mycobacterium ulcerans Agy99 NAD(P) transhydrogenase (subunit alpha) PntAa YP_908132.1 5243606 R 362242 CDS YP_908133.1 118619801 4551323 complement(5244938..5245408) 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; hypothetical protein 5245408 4551323 MUL_4736 Mycobacterium ulcerans Agy99 hypothetical protein YP_908133.1 5244938 R 362242 CDS YP_908134.1 118619802 4551324 complement(5245474..5246352) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 5246352 4551324 MUL_4737 Mycobacterium ulcerans Agy99 hypothetical protein YP_908134.1 5245474 R 362242 CDS YP_908135.1 118619803 4551326 5247721..5248551 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; involved in signal transduction (via dephosphorylation) can dephosphorylated in vitro the phosphotyrosine residue of myelin basic protein (MBP) at ph 7.0. could be involved in virulence by interfering with phosphotyrosine-mediated signals in macrophages [catalytic activity: protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate]; phosphotyrosine protein phosphatase PtpB 5248551 ptpB 4551326 ptpB Mycobacterium ulcerans Agy99 phosphotyrosine protein phosphatase PtpB YP_908135.1 5247721 D 362242 CDS YP_908136.1 118619804 4551327 5248870..5249256 1 NC_008611.1 cytoplasmic protein; hypothetical protein 5249256 4551327 MUL_4741 Mycobacterium ulcerans Agy99 hypothetical protein YP_908136.1 5248870 D 362242 CDS YP_908137.1 118619805 4551328 complement(5249304..5250032) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; hypothetical protein 5250032 4551328 MUL_4742 Mycobacterium ulcerans Agy99 hypothetical protein YP_908137.1 5249304 R 362242 CDS YP_908138.1 118619806 4551330 5251308..5252186 1 NC_008611.1 predicted by Cello and psort. Detected in the secreted fraction by 2D-LC-MS-MS.; secreted protein; possibly hydrolyzes specific sugar (hydrolyzation of glycosidic bond) and could be involved in exopolysaccharide biosynthesis/degradation. could also have a lytic activity against cell walls.; beta-1,3-glucanase precursor 5252186 4551330 MUL_4744 Mycobacterium ulcerans Agy99 beta-1,3-glucanase precursor YP_908138.1 5251308 D 362242 CDS YP_908139.1 118619807 4551332 complement(5252601..5252918) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; C-term transposase for IS2404 5252918 4551332 MUL_4746 Mycobacterium ulcerans Agy99 C-term transposase for IS2404 YP_908139.1 5252601 R 362242 CDS YP_908140.1 118619808 4551333 complement(5252943..5253647) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; N-term transposase for IS2404 5253647 4551333 MUL_4747 Mycobacterium ulcerans Agy99 N-term transposase for IS2404 YP_908140.1 5252943 R 362242 CDS YP_908141.1 118619809 4551335 complement(5259211..5260257) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 5260257 4551335 MUL_4749 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_908141.1 5259211 R 362242 CDS YP_908142.1 118619810 4551337 complement(5266112..5266429) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; C-term transposase for IS2404 5266429 4551337 MUL_4751 Mycobacterium ulcerans Agy99 C-term transposase for IS2404 YP_908142.1 5266112 R 362242 CDS YP_908143.1 118619811 4550889 complement(5266454..5267158) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; N-term transposase for IS2404 5267158 4550889 MUL_4752 Mycobacterium ulcerans Agy99 N-term transposase for IS2404 YP_908143.1 5266454 R 362242 CDS YP_908144.1 118619812 4550890 complement(5267954..5270893) 1 NC_008611.1 membrane protein; involved in signal transduction (via phosphorylation) involved in transcriptional regulatory mechanism and in the regulation of secondary metabolites [catalytic activity: ATP + a protein = ADP + a phosphoprotein]; serine/threonine-protein kinase transcriptional regulatory protein PknK_3 5270893 pknK_3 4550890 pknK_3 Mycobacterium ulcerans Agy99 serine/threonine-protein kinase transcriptional regulatory protein PknK_3 YP_908144.1 5267954 R 362242 CDS YP_908145.1 118619813 4550891 complement(5271118..5274102) 1 NC_008611.1 membrane protein; involved in signal transduction (via phosphorylation) involved in transcriptional regulatory mechanism and in the regulation of secondary metabolites [catalytic activity: ATP + a protein = ADP + a phosphoprotein]; serine/threonine-protein kinase transcriptional regulatory protein PknK_2 5274102 pknK_2 4550891 pknK_2 Mycobacterium ulcerans Agy99 serine/threonine-protein kinase transcriptional regulatory protein PknK_2 YP_908145.1 5271118 R 362242 CDS YP_908146.1 118619814 4550892 complement(5274163..5274381) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 5274381 4550892 MUL_4755 Mycobacterium ulcerans Agy99 hypothetical protein YP_908146.1 5274163 R 362242 CDS YP_908147.1 118619815 4550893 5274750..5275286 1 NC_008611.1 membrane protein; hypothetical protein 5275286 4550893 MUL_4756 Mycobacterium ulcerans Agy99 hypothetical protein YP_908147.1 5274750 D 362242 CDS YP_908148.1 118619816 4550894 5275312..5275668 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; hypothetical protein 5275668 4550894 MUL_4757 Mycobacterium ulcerans Agy99 hypothetical protein YP_908148.1 5275312 D 362242 CDS YP_908149.1 118619817 4550895 complement(5275750..5276718) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; possibly binds NADP and acts through a one-electron transfer process. quinones are supposed to be the best substrates. may act in the detoxification of xenobiotics [catalytic activity: NADPH + quinone = NADP+ + semiquinone]; quinone oxidoreductase 5276718 4550895 MUL_4758 Mycobacterium ulcerans Agy99 quinone oxidoreductase YP_908149.1 5275750 R 362242 CDS YP_908150.1 118619818 4550896 complement(5276723..5277583) 1 NC_008611.1 Found in the cytoplasmic and membrane fractions by LC-MS/MS. Also detected in the secreted protein and extracellular matrix fractions by proteomics.; cytoplasmic protein; function unknown, possibly involved in cellular metabolism.; short-chain type dehydrogenase/reductase 5277583 4550896 MUL_4759 Mycobacterium ulcerans Agy99 short-chain type dehydrogenase/reductase YP_908150.1 5276723 R 362242 CDS YP_908151.1 118619819 4550897 complement(5277656..5279140) 1 NC_008611.1 Detected in the membrane and the cytoplasmic fractions by proteomics.; cytoplasmic protein; function unknown, probably involved in cellular metabolism [catalytic activity: an aldehyde + NAD+ + H2O = an acid + NADH]; aldehyde dehydrogenase (NAD+) dependent 5279140 4550897 MUL_4760 Mycobacterium ulcerans Agy99 aldehyde dehydrogenase (NAD+) dependent YP_908151.1 5277656 R 362242 CDS YP_908152.1 118619820 4550898 complement(5279290..5280156) 1 NC_008611.1 cytoplasmic protein; O-methyltransferase 5280156 4550898 MUL_4761 Mycobacterium ulcerans Agy99 O-methyltransferase YP_908152.1 5279290 R 362242 CDS YP_908153.1 118619821 4550899 complement(5280226..5281158) 1 NC_008611.1 cytoplasmic protein; O-methyltransferase 5281158 4550899 MUL_4762 Mycobacterium ulcerans Agy99 O-methyltransferase YP_908153.1 5280226 R 362242 CDS YP_908154.1 118619822 4550900 complement(5281181..5282113) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 5282113 4550900 MUL_4763 Mycobacterium ulcerans Agy99 hypothetical protein YP_908154.1 5281181 R 362242 CDS YP_908155.1 118619823 4550901 complement(5282130..5282237) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 5282237 4550901 MUL_4764 Mycobacterium ulcerans Agy99 hypothetical protein YP_908155.1 5282130 R 362242 CDS YP_908156.1 118619824 4550902 complement(5282258..5282896) 1 NC_008611.1 cytoplasmic protein; involved in transcriptional mechanism.; TetR family transcriptional regulator 5282896 4550902 MUL_4765 Mycobacterium ulcerans Agy99 TetR family transcriptional regulator YP_908156.1 5282258 R 362242 CDS YP_908157.1 118619825 4550903 complement(5282893..5283897) 1 NC_008611.1 Detected in the cytoplasmic fraction by proteomics.; cytoplasmic protein; hypothetical protein 5283897 4550903 MUL_4766 Mycobacterium ulcerans Agy99 hypothetical protein YP_908157.1 5282893 R 362242 CDS YP_908158.1 118619826 4550906 5286515..5286916 1 NC_008611.1 cytoplasmic protein; hypothetical protein 5286916 4550906 MUL_4769 Mycobacterium ulcerans Agy99 hypothetical protein YP_908158.1 5286515 D 362242 CDS YP_908159.1 118619827 4550907 complement(5286903..5287283) 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; hypothetical protein 5287283 4550907 MUL_4770 Mycobacterium ulcerans Agy99 hypothetical protein YP_908159.1 5286903 R 362242 CDS YP_908160.1 118619828 4550908 complement(5287393..5288415) 1 NC_008611.1 cytoplasmic protein; function unknown, probably involved in cellular metabolism.; oxidoreductase 5288415 4550908 MUL_4771 Mycobacterium ulcerans Agy99 oxidoreductase YP_908160.1 5287393 R 362242 CDS YP_908161.1 118619829 4550007 complement(5288412..5288918) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 5288918 4550007 MUL_4772 Mycobacterium ulcerans Agy99 hypothetical protein YP_908161.1 5288412 R 362242 CDS YP_908162.1 118619830 4550008 5289078..5289593 1 NC_008611.1 this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; provides protection against oxidative stress; methionine sulfoxide reductase A 5289593 msrA 4550008 msrA Mycobacterium ulcerans Agy99 methionine sulfoxide reductase A YP_908162.1 5289078 D 362242 CDS YP_908163.1 118619831 4550010 5291084..5291689 1 NC_008611.1 cytoplasmic protein; could be involved in transcriptional mechanism.; transcriptional regulatory protein 5291689 4550010 MUL_4775 Mycobacterium ulcerans Agy99 transcriptional regulatory protein YP_908163.1 5291084 D 362242 CDS YP_908164.1 118619832 4550011 5291735..5291947 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.Also detected in the membrane fraction by proteomics (2D-LC-MS/MS); cytoplasmic protein; hypothetical protein 5291947 4550011 MUL_4776 Mycobacterium ulcerans Agy99 hypothetical protein YP_908164.1 5291735 D 362242 CDS YP_908165.1 118619833 4550012 5291954..5292997 1 NC_008611.1 cytoplasmic protein; oxido-reduction; zinc-dependent alcohol dehydrogenase 5292997 4550012 MUL_4777 Mycobacterium ulcerans Agy99 zinc-dependent alcohol dehydrogenase YP_908165.1 5291954 D 362242 CDS YP_908166.1 118619834 4550013 complement(5293061..5293951) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; thought to be involved in detoxification reactions following oxidative damage to lipids [catalytic activity: an epoxide + H(2)O = a glycol]; epoxide hydrolase EphF 5293951 ephF 4550013 ephF Mycobacterium ulcerans Agy99 epoxide hydrolase EphF YP_908166.1 5293061 R 362242 CDS YP_908167.1 118619835 4550015 5295261..5295860 1 NC_008611.1 cytoplasmic protein; involved in transcriptional mechanism.; TetR family transcriptional regulator 5295860 4550015 MUL_4780 Mycobacterium ulcerans Agy99 TetR family transcriptional regulator YP_908167.1 5295261 D 362242 CDS YP_908168.1 118619836 4550016 5295857..5296966 1 NC_008611.1 cytoplasmic protein; hypothetical protein 5296966 4550016 MUL_4781 Mycobacterium ulcerans Agy99 hypothetical protein YP_908168.1 5295857 D 362242 CDS YP_908169.1 118619837 4550017 complement(5296968..5298017) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; function unknown, probably involved in cellular metabolism.; coenzyme F420-dependent oxidoreductase 5298017 4550017 MUL_4782 Mycobacterium ulcerans Agy99 coenzyme F420-dependent oxidoreductase YP_908169.1 5296968 R 362242 CDS YP_908170.1 118619838 4550018 complement(5298017..5298541) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 5298541 4550018 MUL_4783 Mycobacterium ulcerans Agy99 hypothetical protein YP_908170.1 5298017 R 362242 CDS YP_908171.1 118619839 4550019 complement(5298811..5299944) 1 NC_008611.1 membrane protein; thought to be involved in lipid metabolism [catalytic activity: linoleoyl-CoA + ah(2) + O(2) = gamma- linolenoyl-CoA + a + 2 H(2)O]; linoleoyl-CoA desaturase, DesA3_2 5299944 desA3_2 4550019 desA3_2 Mycobacterium ulcerans Agy99 linoleoyl-CoA desaturase, DesA3_2 YP_908171.1 5298811 R 362242 CDS YP_908172.1 118619840 4550020 complement(5299980..5301077) 1 NC_008611.1 cytoplasmic protein; function unknown, contains flavodoxin reductases (ferredoxin-NADPH reductases) family 1 domain. [energy production and conversion]; flavodoxin oxidoreductase 5301077 4550020 MUL_4786 Mycobacterium ulcerans Agy99 flavodoxin oxidoreductase YP_908172.1 5299980 R 362242 CDS YP_908173.1 118619841 4550021 5301148..5301816 1 NC_008611.1 cytoplasmic protein; involved in transcriptional mechanism.; TetR family transcriptional regulator 5301816 4550021 MUL_4787 Mycobacterium ulcerans Agy99 TetR family transcriptional regulator YP_908173.1 5301148 D 362242 CDS YP_908174.1 118619842 4550023 complement(5304070..5304618) 1 NC_008611.1 cytoplasmic protein; function unknown, probably involved in cellular metabolism.; acetyltransferase 5304618 4550023 MUL_4789 Mycobacterium ulcerans Agy99 acetyltransferase YP_908174.1 5304070 R 362242 CDS YP_908175.1 118619843 4550024 5304780..5306072 1 NC_008611.1 Detected in the cytoplamic fraction by LC-MS/MS. Also detected in the membrane fraction by proteomics (2D- LC-MS/MS); cytoplasmic protein; function unknown, but involved in lipid degradation.; acyl-CoA dehydrogenase FadE1 5306072 fadE1 4550024 fadE1 Mycobacterium ulcerans Agy99 acyl-CoA dehydrogenase FadE1 YP_908175.1 5304780 D 362242 CDS YP_908176.1 118619844 4550025 complement(5306153..5306608) 1 NC_008611.1 cytoplasmic protein; acyl dehydratase 5306608 4550025 MUL_4791 Mycobacterium ulcerans Agy99 acyl dehydratase YP_908176.1 5306153 R 362242 CDS YP_908177.1 118619845 4552146 5306645..5307142 1 NC_008611.1 cytoplasmic protein; phosphoesterase 5307142 4552146 MUL_4792 Mycobacterium ulcerans Agy99 phosphoesterase YP_908177.1 5306645 D 362242 CDS YP_908178.1 118619846 4552147 5307495..5308535 1 NC_008611.1 Also detected in the cytoplasm and the membrane fractions by proteomics.; secreted protein; proteins of the antigen 85 complex are responsible for the high affinity of mycobacteria to fibronectin. possesses a mycolyltransferase activity required for the biogenesis of trehalose dimycolate (cord factor), a dominant structure necessary for maintaining cell wall integrity.; secreted antigen 85-C FbpC 5308535 fbpC 4552147 fbpC Mycobacterium ulcerans Agy99 secreted antigen 85-C FbpC YP_908178.1 5307495 D 362242 CDS YP_908179.1 118619847 4552149 complement(5309411..5310778) 1 NC_008611.1 Detected in the extracellular matrix and the cytoplasmic fractions by proteomics.; cytoplasmic protein; hypothetical protein 5310778 4552149 MUL_4796 Mycobacterium ulcerans Agy99 hypothetical protein YP_908179.1 5309411 R 362242 CDS YP_908180.1 118619848 4552150 complement(5310852..5312645) 1 NC_008611.1 Detected in the membrane fraction by proteomics (2D- LC-MS/MS); cytoplasmic protein; involved in trehalose biosynthesis (protective effect) converts maltose to trehalose. mycobacteria can produce trehalose from glucose 6-phosphate and UDP-glucose (the OtsA-OtsB pathway) from glycogen-like alpha(1-->4)- linked glucose polymers (the TreY-TreZ pathway) and from maltose (the TreS pathway); trehalose synthase TreS 5312645 treS 4552150 treS Mycobacterium ulcerans Agy99 trehalose synthase TreS YP_908180.1 5310852 R 362242 CDS YP_908181.1 118619849 4552151 complement(5312758..5313789) 1 NC_008611.1 Three isoforms were also detected in the cytoplasm.; secreted protein; function unknown, possibly hydrolyzes peptides and/or proteins (seems to cleave preferentially after serine residues); serine protease PepA 5313789 pepA 4552151 pepA Mycobacterium ulcerans Agy99 serine protease PepA YP_908181.1 5312758 R 362242 CDS YP_908182.1 118619850 4552152 complement(5313944..5314444) 1 NC_008611.1 cytoplasmic protein; maybe involved in oxidization of aromatic hydrocarbons; dioxygenase beta subunit 5314444 4552152 MUL_4799 Mycobacterium ulcerans Agy99 dioxygenase beta subunit YP_908182.1 5313944 R 362242 CDS YP_908183.1 118619851 4552153 5314506..5314916 1 NC_008611.1 cytoplasmic protein; hypothetical protein 5314916 4552153 MUL_4800 Mycobacterium ulcerans Agy99 hypothetical protein YP_908183.1 5314506 D 362242 CDS YP_908184.1 118619852 4552155 5317261..5317737 1 NC_008611.1 membrane protein; hypothetical protein 5317737 4552155 MUL_4802 Mycobacterium ulcerans Agy99 hypothetical protein YP_908184.1 5317261 D 362242 CDS YP_908185.1 118619853 4552156 complement(5317734..5319368) 1 NC_008611.1 activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 5319368 fadD7 4552156 fadD7 Mycobacterium ulcerans Agy99 acyl-CoA synthetase YP_908185.1 5317734 R 362242 CDS YP_908186.1 118619854 4552157 5319635..5321398 1 NC_008611.1 catalyzes the formation of formyl-CoA from oxalyl-CoA; putative oxalyl-CoA decarboxylase 5321398 oxcA 4552157 oxcA Mycobacterium ulcerans Agy99 putative oxalyl-CoA decarboxylase YP_908186.1 5319635 D 362242 CDS YP_908187.1 118619855 4552158 complement(5321555..5322313) 1 NC_008611.1 cytoplasmic protein; could effect functions of OxyR during evolution.; oxidative stress response regulatory protein OxyS 5322313 oxyS 4552158 oxyS Mycobacterium ulcerans Agy99 oxidative stress response regulatory protein OxyS YP_908187.1 5321555 R 362242 CDS YP_908188.1 118619856 4552159 5322759..5323484 1 NC_008611.1 secreted protein; hypothetical protein 5323484 4552159 MUL_4806 Mycobacterium ulcerans Agy99 hypothetical protein YP_908188.1 5322759 D 362242 CDS YP_908189.1 118619857 4552160 complement(5323536..5325284) 1 NC_008611.1 membrane protein; H(+)-stimulated, highly selective, divalent cation uptake system. responsible for the translocation of the divalent metal across the membrane.; divalent cation-transport integral membrane protein 5325284 4552160 MUL_4807 Mycobacterium ulcerans Agy99 divalent cation-transport integral membrane protein YP_908189.1 5323536 R 362242 CDS YP_908190.1 118619858 4552161 complement(5325392..5325574) 1 NC_008611.1 hypothetical protein 5325574 4552161 MUL_4808 Mycobacterium ulcerans Agy99 hypothetical protein YP_908190.1 5325392 R 362242 CDS YP_908191.1 118619859 4552162 5326182..5326847 1 NC_008611.1 cytoplasmic protein; thought to be involved in transfer of methyl group.; O-methyltransferase 5326847 4552162 MUL_4809 Mycobacterium ulcerans Agy99 O-methyltransferase YP_908191.1 5326182 D 362242 CDS YP_908192.1 118619860 4552163 complement(5326851..5328863) 1 NC_008611.1 membrane protein; function unknown, probably involved in cellular metabolism.; transmembrane acyltransferase 5328863 4552163 MUL_4810 Mycobacterium ulcerans Agy99 transmembrane acyltransferase YP_908192.1 5326851 R 362242 CDS YP_908193.1 118619861 4550657 complement(5329101..5330288) 1 NC_008611.1 cytoplasmic protein; function unknown. possibly involved in energy production and conversion.; hypothetical protein 5330288 4550657 MUL_4811 Mycobacterium ulcerans Agy99 hypothetical protein YP_908193.1 5329101 R 362242 CDS YP_908194.1 118619862 4550658 complement(5330314..5331249) 1 NC_008611.1 cytoplasmic protein; function unknown, possibly involved in cellular metabolism.; short-chain type dehydrogenase/reductase 5331249 4550658 MUL_4812 Mycobacterium ulcerans Agy99 short-chain type dehydrogenase/reductase YP_908194.1 5330314 R 362242 CDS YP_908195.1 118619863 4550659 complement(5331474..5333111) 1 NC_008611.1 cytoplasmic protein; function unknown, probably involved in cellular metabolism; monoxygenase 5333111 4550659 MUL_4813 Mycobacterium ulcerans Agy99 monoxygenase YP_908195.1 5331474 R 362242 CDS YP_908196.1 118619864 4550660 complement(5333108..5334289) 1 NC_008611.1 cytoplasmic protein; function unknown, probably involved in cellular metabolism; monooxygenase 5334289 4550660 MUL_4814 Mycobacterium ulcerans Agy99 monooxygenase YP_908196.1 5333108 R 362242 CDS YP_908197.1 118619865 4550663 5336713..5338335 1 NC_008611.1 cytoplasmic protein; hypothetical protein 5338335 4550663 MUL_4817 Mycobacterium ulcerans Agy99 hypothetical protein YP_908197.1 5336713 D 362242 CDS YP_908198.1 118619866 4550664 5338348..5339127 1 NC_008611.1 cytoplasmic protein; involved in transcriptional mechanism.; GntR family transcriptional regulator 5339127 4550664 MUL_4818 Mycobacterium ulcerans Agy99 GntR family transcriptional regulator YP_908198.1 5338348 D 362242 CDS YP_908199.1 118619867 4550666 5340749..5341465 1 NC_008611.1 cytoplasmic protein; function unknown, possibly involved in cellular metabolism.; short-chain type dehydrogenase/reductase 5341465 4550666 MUL_4820 Mycobacterium ulcerans Agy99 short-chain type dehydrogenase/reductase YP_908199.1 5340749 D 362242 CDS YP_908200.1 118619868 4550668 complement(5342015..5342779) 1 NC_008611.1 membrane protein; serine protease 5342779 4550668 MUL_4822 Mycobacterium ulcerans Agy99 serine protease YP_908200.1 5342015 R 362242 CDS YP_908201.1 118619869 4550670 complement(5344361..5345428) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 5345428 4550670 MUL_4824 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_908201.1 5344361 R 362242 CDS YP_908202.1 118619870 4550671 5346190..5346396 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS, and also in the membrane fraction by proteomics (LC- MS/MS); cytoplasmic protein; hypothetical protein 5346396 4550671 MUL_4825 Mycobacterium ulcerans Agy99 hypothetical protein YP_908202.1 5346190 D 362242 CDS YP_908203.1 118619871 4550672 5346865..5351727 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS) Also detected in the cytoplasmic fraction by 2D-LC- MS/MS.; membrane protein; cation-transporting ATPase; possibly catalyzes the transport of a cation (possibly magnesium) with the hydrolyse of ATP [catalytic activity: ATP + H(2)O + cation(in) = ADP + phosphate + cation(out)]; cation-transporter ATPase I CtpI 5351727 ctpI 4550672 ctpI Mycobacterium ulcerans Agy99 cation-transporter ATPase I CtpI YP_908203.1 5346865 D 362242 CDS YP_908204.1 118619872 4550673 complement(5351700..5353286) 1 NC_008611.1 activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 5353286 fadD12_2 4550673 fadD12_2 Mycobacterium ulcerans Agy99 acyl-CoA synthetase YP_908204.1 5351700 R 362242 CDS YP_908205.1 118619873 4550674 complement(5353289..5354188) 1 NC_008611.1 cytoplasmic protein; function unknown; supposed involved in cellular metabolism.; short-chain type dehydrogenase/reductase 5354188 4550674 MUL_4828 Mycobacterium ulcerans Agy99 short-chain type dehydrogenase/reductase YP_908205.1 5353289 R 362242 CDS YP_908206.1 118619874 4550675 complement(5354358..5354630) 1 NC_008611.1 RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 type B 5354630 rpmE2 4550675 rpmE2 Mycobacterium ulcerans Agy99 50S ribosomal protein L31 type B YP_908206.1 5354358 R 362242 CDS YP_908207.1 118619875 4552017 complement(5354627..5355823) 1 NC_008611.1 Detected in the membrane fraction by proteomics.; cytoplasmic protein; hypothetical protein 5355823 4552017 MUL_4830 Mycobacterium ulcerans Agy99 hypothetical protein YP_908207.1 5354627 R 362242 CDS YP_908208.1 118619876 4552018 5355953..5356189 1 NC_008611.1 cytoplasmic protein; involved in ribosome activity; 50S ribosomal protein L28 RpmB2 5356189 rpmB2 4552018 rpmB2 Mycobacterium ulcerans Agy99 50S ribosomal protein L28 RpmB2 YP_908208.1 5355953 D 362242 CDS YP_908209.1 118619877 4552019 5356189..5356353 1 NC_008611.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif; 50S ribosomal protein L33 5356353 rpmG 4552019 rpmG Mycobacterium ulcerans Agy99 50S ribosomal protein L33 YP_908209.1 5356189 D 362242 CDS YP_908210.1 118619878 4552020 5356354..5356659 1 NC_008611.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif; 30S ribosomal protein S14 5356659 rpsN 4552020 rpsN Mycobacterium ulcerans Agy99 30S ribosomal protein S14 YP_908210.1 5356354 D 362242 CDS YP_908211.1 118619879 4552021 5356666..5356929 1 NC_008611.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit; 30S ribosomal protein S18 5356929 rpsR2 4552021 rpsR2 Mycobacterium ulcerans Agy99 30S ribosomal protein S18 YP_908211.1 5356666 D 362242 CDS YP_908212.1 118619880 4552022 complement(5356950..5357900) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 5357900 4552022 MUL_4835 Mycobacterium ulcerans Agy99 hypothetical protein YP_908212.1 5356950 R 362242 CDS YP_908213.1 118619881 4552023 5358100..5358693 1 NC_008611.1 cytoplasmic protein; involved in transcriptional mechanism.; transcriptional regulatory protein 5358693 4552023 MUL_4837 Mycobacterium ulcerans Agy99 transcriptional regulatory protein YP_908213.1 5358100 D 362242 CDS YP_908214.1 118619882 4552024 5358696..5360072 1 NC_008611.1 cytoplasmic protein; function unknown, probably involved in cellular metabolism; lignin peroxidase LipJ 5360072 lipJ 4552024 lipJ Mycobacterium ulcerans Agy99 lignin peroxidase LipJ YP_908214.1 5358696 D 362242 CDS YP_908215.1 118619883 4552028 5364216..5365262 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 5365262 4552028 MUL_4842 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_908215.1 5364216 D 362242 CDS YP_908216.1 118619884 4552030 5365829..5366635 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; function unknown, probably involved in cellular metabolism; short-chain type dehydrogenase/reductase 5366635 4552030 MUL_4844 Mycobacterium ulcerans Agy99 short-chain type dehydrogenase/reductase YP_908216.1 5365829 D 362242 CDS YP_908217.1 118619885 4552031 5366880..5369153 1 NC_008611.1 membrane protein; cation-transporting ATPase; possibly catalyzes the transport of a cation (possibly coopper) with the hydrolyse of ATP [catalytic activity: ATP + H(2)O + cation(in) = ADP + orthophosphate + cation(out)]; cation-transporter p-type ATPase B CtpB 5369153 ctpB 4552031 ctpB Mycobacterium ulcerans Agy99 cation-transporter p-type ATPase B CtpB YP_908217.1 5366880 D 362242 CDS YP_908218.1 118619886 4552032 5369146..5369364 1 NC_008611.1 Detected in the cytoplasmic and secreted protein fractions by 2D-LC-MS/MS.; secreted protein; hypothetical protein 5369364 4552032 MUL_4846 Mycobacterium ulcerans Agy99 hypothetical protein YP_908218.1 5369146 D 362242 CDS YP_908219.1 118619887 4552033 complement(5369381..5371384) 1 NC_008611.1 membrane protein; integral membrane protein 5371384 4552033 MUL_4847 Mycobacterium ulcerans Agy99 integral membrane protein YP_908219.1 5369381 R 362242 CDS YP_908220.1 118619888 4552034 5371549..5372292 1 NC_008611.1 secreted protein; hypothetical protein 5372292 4552034 MUL_4848 Mycobacterium ulcerans Agy99 hypothetical protein YP_908220.1 5371549 D 362242 CDS YP_908221.1 118619889 4549613 complement(5372328..5372882) 1 NC_008611.1 cytoplasmic protein; involved in promoter recognition, transcription initiation.; ECF subfamily RNA polymerase sigma factor 5372882 sigC_1 4549613 sigC_1 Mycobacterium ulcerans Agy99 ECF subfamily RNA polymerase sigma factor YP_908221.1 5372328 R 362242 CDS YP_908222.1 118619890 4549614 5373007..5375298 1 NC_008611.1 membrane protein; cation-transporting ATPase; possibly catalyzes the transport of a cation (possibly copper) with the hydrolyse of ATP [catalytic activity: ATP + H(2)O + cation(in) = ADP + phosphate + cation(out)]; cation transporter p-type ATPase a CtpA 5375298 ctpA 4549614 ctpA Mycobacterium ulcerans Agy99 cation transporter p-type ATPase a CtpA YP_908222.1 5373007 D 362242 CDS YP_908223.1 118619891 4549615 complement(5375319..5376044) 1 NC_008611.1 membrane protein; hypothetical protein 5376044 4549615 MUL_4851 Mycobacterium ulcerans Agy99 hypothetical protein YP_908223.1 5375319 R 362242 CDS YP_908224.1 118619892 4549616 complement(5376126..5376935) 1 NC_008611.1 cytoplasmic protein; function unknown, but supposed involved in lipid metabolism; O-methyltransferase Omt_1 5376935 omt_1 4549616 omt_1 Mycobacterium ulcerans Agy99 O-methyltransferase Omt_1 YP_908224.1 5376126 R 362242 CDS YP_908225.1 118619893 4549617 5377263..5378681 1 NC_008611.1 PPE1; membrane protein; PPE family protein 5378681 4549617 MUL_4853 Mycobacterium ulcerans Agy99 PPE family protein YP_908225.1 5377263 D 362242 CDS YP_908226.1 118619894 4549618 5378875..5379744 1 NC_008611.1 cytoplasmic protein; function unknown, probably involved in cellular metabolism.; oxidoreductase 5379744 4549618 MUL_4854 Mycobacterium ulcerans Agy99 oxidoreductase YP_908226.1 5378875 D 362242 CDS YP_908227.1 118619895 4549619 5379741..5380295 1 NC_008611.1 cytoplasmic protein; hypothetical protein 5380295 4549619 MUL_4855 Mycobacterium ulcerans Agy99 hypothetical protein YP_908227.1 5379741 D 362242 CDS YP_908228.1 118619896 4549620 5380324..5381919 1 NC_008611.1 activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 5381919 fadD10 4549620 fadD10 Mycobacterium ulcerans Agy99 acyl-CoA synthetase YP_908228.1 5380324 D 362242 CDS YP_908229.1 118619897 4549621 5381924..5382163 1 NC_008611.1 cytoplasmic protein; hypothetical protein 5382163 4549621 MUL_4857 Mycobacterium ulcerans Agy99 hypothetical protein YP_908229.1 5381924 D 362242 CDS YP_908230.1 118619898 4549622 5382160..5386410 1 NC_008611.1 membrane protein; involved in lipid metabolism.; non-ribosomal peptide synthetase 5386410 4549622 MUL_4858 Mycobacterium ulcerans Agy99 non-ribosomal peptide synthetase YP_908230.1 5382160 D 362242 CDS YP_908231.1 118619899 4549624 complement(5389428..5390231) 1 NC_008611.1 cytoplasmic protein; function unknown, but possibly involvement in lipid metabolism.; ketoacyl reductase 5390231 4549624 MUL_4860 Mycobacterium ulcerans Agy99 ketoacyl reductase YP_908231.1 5389428 R 362242 CDS YP_908232.1 118619900 4549625 complement(5390333..5390818) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 5390818 4549625 MUL_4861 Mycobacterium ulcerans Agy99 hypothetical protein YP_908232.1 5390333 R 362242 CDS YP_908233.1 118619901 4549626 complement(5391176..5391931) 1 NC_008611.1 cytoplasmic protein; responsible for cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and s- adenosylhomocysteine (sah) [catalytic activity 1: methylthioadenosine + H2O = adenine + 5-methylthio-D- ribose] [catalytic activity 2: S-adenosyl-L-homocysteine + H2O = adenine + S-D-ribosyl-L-homocysteine]; bifunctional Mta/Sah nucleosidase Mtn 5391931 mtn 4549626 mtn Mycobacterium ulcerans Agy99 bifunctional Mta/Sah nucleosidase Mtn YP_908233.1 5391176 R 362242 CDS YP_908234.1 118619902 4549627 complement(5392042..5392866) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 5392866 4549627 MUL_4863 Mycobacterium ulcerans Agy99 hypothetical protein YP_908234.1 5392042 R 362242 CDS YP_908235.1 118619903 4549628 complement(5392863..5393492) 1 NC_008611.1 cytoplasmic protein; possibly involved in transcriptional mechanism.; TetR family transcriptional regulator 5393492 4549628 MUL_4864 Mycobacterium ulcerans Agy99 TetR family transcriptional regulator YP_908235.1 5392863 R 362242 CDS YP_908236.1 118619904 4549629 complement(5393538..5394398) 1 NC_008611.1 cytoplasmic protein; function unknown, possibly involved in cellular metabolism.; short-chain type dehydrogenase/reductase 5394398 4549629 MUL_4865 Mycobacterium ulcerans Agy99 short-chain type dehydrogenase/reductase YP_908236.1 5393538 R 362242 CDS YP_908237.1 118619905 4549630 5394468..5395082 1 NC_008611.1 cytoplasmic protein; hypothetical protein 5395082 4549630 MUL_4866 Mycobacterium ulcerans Agy99 hypothetical protein YP_908237.1 5394468 D 362242 CDS YP_908238.1 118619906 4549631 complement(5395107..5395877) 1 NC_008611.1 membrane protein; hypothetical protein 5395877 4549631 MUL_4867 Mycobacterium ulcerans Agy99 hypothetical protein YP_908238.1 5395107 R 362242 CDS YP_908239.1 118619907 4550834 5396183..5396983 1 NC_008611.1 cytoplasmic protein; oxidizes fatty acids using specific components (by similarity) [catalytic activity: (3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H(2)O]; enoyl-CoA hydratase, EchA8_7 5396983 echA8_7 4550834 echA8_7 Mycobacterium ulcerans Agy99 enoyl-CoA hydratase, EchA8_7 YP_908239.1 5396183 D 362242 CDS YP_908240.1 118619908 4550835 complement(5397041..5397640) 1 NC_008611.1 cytoplasmic protein; thought to cause methylation.; methyltransferase/methylase 5397640 4550835 MUL_4869 Mycobacterium ulcerans Agy99 methyltransferase/methylase YP_908240.1 5397041 R 362242 CDS YP_908241.1 118619909 4550836 5397757..5398569 1 NC_008611.1 cytoplasmic protein; function unknown, possibly involved in cellular metabolism.; short chain dehydrogenase 5398569 4550836 MUL_4870 Mycobacterium ulcerans Agy99 short chain dehydrogenase YP_908241.1 5397757 D 362242 CDS YP_908242.1 118619910 4550838 5400482..5401639 1 NC_008611.1 cytoplasmic protein; function unknown, generates an aldehyde (or perhaps a ketone) from an alcohol.; zinc-type alcohol dehydrogenase AdhD 5401639 adhD 4550838 adhD Mycobacterium ulcerans Agy99 zinc-type alcohol dehydrogenase AdhD YP_908242.1 5400482 D 362242 CDS YP_908243.1 118619911 4550839 complement(5401523..5403199) 1 NC_008611.1 membrane protein; function unknown, involved in cellular metabolism.; monooxygenase 5403199 4550839 MUL_4873 Mycobacterium ulcerans Agy99 monooxygenase YP_908243.1 5401523 R 362242 CDS YP_908244.1 118619912 4550841 complement(5405098..5405727) 1 NC_008611.1 Detected in the cytoplasmic and membrane fractions by proteomics.; cytoplasmic protein; involved in transcriptional mechanism.; TetR family transcriptional regulator 5405727 4550841 MUL_4875 Mycobacterium ulcerans Agy99 TetR family transcriptional regulator YP_908244.1 5405098 R 362242 CDS YP_908245.1 118619913 4550842 5405877..5406539 1 NC_008611.1 cytoplasmic protein; involved in transcriptional mechanism.; TetR family transcriptional regulator 5406539 4550842 MUL_4876 Mycobacterium ulcerans Agy99 TetR family transcriptional regulator YP_908245.1 5405877 D 362242 CDS YP_908246.1 118619914 4550843 5406536..5407546 1 NC_008611.1 cytoplasmic protein; function unknown. possibly involved in cellular metabolism.; hypothetical protein 5407546 4550843 MUL_4877 Mycobacterium ulcerans Agy99 hypothetical protein YP_908246.1 5406536 D 362242 CDS YP_908247.1 118619915 4550845 complement(5408172..5408645) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 5408645 4550845 MUL_4879 Mycobacterium ulcerans Agy99 hypothetical protein YP_908247.1 5408172 R 362242 CDS YP_908248.1 118619916 4550846 5408848..5409060 1 NC_008611.1 cytoplasmic protein; function unknown, contains copper chaperone domain.; hypothetical protein 5409060 4550846 MUL_4881 Mycobacterium ulcerans Agy99 hypothetical protein YP_908248.1 5408848 D 362242 CDS YP_908249.1 118619917 4550847 5409096..5409947 1 NC_008611.1 secreted protein; hypothetical protein 5409947 4550847 MUL_4882 Mycobacterium ulcerans Agy99 hypothetical protein YP_908249.1 5409096 D 362242 CDS YP_908250.1 118619918 4550849 complement(5412356..5413540) 1 NC_008611.1 membrane protein; function unknown, involved in cellular metabolism.; dioxygenase 5413540 4550849 MUL_4884 Mycobacterium ulcerans Agy99 dioxygenase YP_908250.1 5412356 R 362242 CDS YP_908251.1 118619919 4550850 5413600..5414406 1 NC_008611.1 cytoplasmic protein; hypothetical protein 5414406 4550850 MUL_4885 Mycobacterium ulcerans Agy99 hypothetical protein YP_908251.1 5413600 D 362242 CDS YP_908252.1 118619920 4550851 complement(5414451..5414900) 1 NC_008611.1 cytoplasmic protein; function unknown. contains HTH motif. may be involved in transcription regulation.; hypothetical protein 5414900 4550851 MUL_4886 Mycobacterium ulcerans Agy99 hypothetical protein YP_908252.1 5414451 R 362242 CDS YP_908253.1 118619921 4554172 complement(5415969..5416559) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 5416559 4554172 MUL_4888 Mycobacterium ulcerans Agy99 hypothetical protein YP_908253.1 5415969 R 362242 CDS YP_908254.1 118619922 4554173 complement(5416573..5417196) 1 NC_008611.1 secreted protein; hypothetical protein 5417196 4554173 MUL_4889 Mycobacterium ulcerans Agy99 hypothetical protein YP_908254.1 5416573 R 362242 CDS YP_908255.1 118619923 4554174 complement(5417335..5417940) 1 NC_008611.1 cytoplasmic protein; possibly involved in transcriptional mechanism.; transcriptional regulatory protein 5417940 4554174 MUL_4890 Mycobacterium ulcerans Agy99 transcriptional regulatory protein YP_908255.1 5417335 R 362242 CDS YP_908256.1 118619924 4554175 5418001..5418831 1 NC_008611.1 cytoplasmic protein; function unknown, probably involved in cellular metabolism.; oxidoreductase 5418831 4554175 MUL_4891 Mycobacterium ulcerans Agy99 oxidoreductase YP_908256.1 5418001 D 362242 CDS YP_908257.1 118619925 4554176 complement(5418895..5419488) 1 NC_008611.1 cytoplasmic protein; involved in transcriptional mechanism.; TetR family transcriptional regulator 5419488 4554176 MUL_4892 Mycobacterium ulcerans Agy99 TetR family transcriptional regulator YP_908257.1 5418895 R 362242 CDS YP_908258.1 118619926 4554177 5419623..5420648 1 NC_008611.1 cytoplasmic protein; hypothetical protein 5420648 4554177 MUL_4893 Mycobacterium ulcerans Agy99 hypothetical protein YP_908258.1 5419623 D 362242 CDS YP_908259.1 118619927 4554179 complement(5421294..5422637) 1 NC_008611.1 cytoplasmic protein; required for the transposition of the insertion element IS2606.; transposase for IS2606 5422637 4554179 MUL_4895 Mycobacterium ulcerans Agy99 transposase for IS2606 YP_908259.1 5421294 R 362242 CDS YP_908260.1 118619928 4554180 complement(5423065..5424111) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 5424111 4554180 MUL_4896 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_908260.1 5423065 R 362242 CDS YP_908261.1 118619929 4554183 5426406..5426963 1 NC_008611.1 cytoplasmic protein; hypothetical protein 5426963 4554183 MUL_4899 Mycobacterium ulcerans Agy99 hypothetical protein YP_908261.1 5426406 D 362242 CDS YP_908262.1 118619930 4554184 complement(5427022..5428635) 1 NC_008611.1 membrane protein; function unknown, probably involved in cellular metabolism; hypothetical protein 5428635 4554184 MUL_4900 Mycobacterium ulcerans Agy99 hypothetical protein YP_908262.1 5427022 R 362242 CDS YP_908263.1 118619931 4554185 complement(5428753..5430138) 1 NC_008611.1 cytoplasmic protein; involved in gluconeogenesis from serine [catalytic activity: L-serine + H2O = pyruvate + NH3 + H2O]; L-serine dehydratase SdaA 5430138 sdaA 4554185 sdaA Mycobacterium ulcerans Agy99 L-serine dehydratase SdaA YP_908263.1 5428753 R 362242 CDS YP_908264.1 118619932 4554186 complement(5430135..5431412) 1 NC_008611.1 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate; serine hydroxymethyltransferase 5431412 glyA 4554186 glyA Mycobacterium ulcerans Agy99 serine hydroxymethyltransferase YP_908264.1 5430135 R 362242 CDS YP_908265.1 118619933 4554187 complement(5431409..5431813) 1 NC_008611.1 cytoplasmic protein; the glycine cleavage system catalyses the degradation of glycine. the H protein shuttles the methylamine group of glycine from the P protein to the T protein; glycine cleavage system H protein GcvH_1 5431813 gcvH_1 4554187 gcvH_1 Mycobacterium ulcerans Agy99 glycine cleavage system H protein GcvH_1 YP_908265.1 5431409 R 362242 CDS YP_908266.1 118619934 4553749 5436233..5436331 1 NC_008611.1 hypothetical protein 5436331 4553749 MUL_4906 Mycobacterium ulcerans Agy99 hypothetical protein YP_908266.1 5436233 D 362242 CDS YP_908267.1 118619935 4553751 complement(5437540..5438586) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 5438586 4553751 MUL_4908 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_908267.1 5437540 R 362242 CDS YP_908268.1 118619936 4553752 complement(5439094..5440269) 1 NC_008611.1 membrane protein; PE-PGRS family protein 5440269 4553752 MUL_4909 Mycobacterium ulcerans Agy99 PE-PGRS family protein YP_908268.1 5439094 R 362242 CDS YP_908269.1 118619937 4553753 complement(5440660..5440929) 1 NC_008611.1 disruption by insertion sequence (missing 11 aa); secreted protein; EsaT-6 like protein EsxP_2 5440929 esxP_2 4553753 esxP_2 Mycobacterium ulcerans Agy99 EsaT-6 like protein EsxP_2 YP_908269.1 5440660 R 362242 CDS YP_908270.1 118619938 4553754 5441233..5441937 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; N-term transposase for IS2404 5441937 4553754 MUL_4911 Mycobacterium ulcerans Agy99 N-term transposase for IS2404 YP_908270.1 5441233 D 362242 CDS YP_908271.1 118619939 4553755 5441962..5442279 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; C-term transposase for IS2404 5442279 4553755 MUL_4912 Mycobacterium ulcerans Agy99 C-term transposase for IS2404 YP_908271.1 5441962 D 362242 CDS YP_908272.1 118619940 4553757 complement(5444883..5446121) 1 NC_008611.1 membrane protein; function unknown, but thought involved in host cell invasion.; MCE-family protein Mce6F 5446121 mce6F 4553757 mce6F Mycobacterium ulcerans Agy99 MCE-family protein Mce6F YP_908272.1 5444883 R 362242 CDS YP_908273.1 118619941 4553758 complement(5446118..5447245) 1 NC_008611.1 membrane protein; function unknown, but thought to be involved in host cell invasion.; MCE family lipoprotein Mce6E 5447245 mce6E 4553758 mce6E Mycobacterium ulcerans Agy99 MCE family lipoprotein Mce6E YP_908273.1 5446118 R 362242 CDS YP_908274.1 118619942 4553759 complement(5447242..5448354) 1 NC_008611.1 Detected in the membrane fraction by proteomics (2D- LC-MS/MS); membrane protein; function unknown, but thought to be involved in host cell invasion.; MCE-family protein Mce6D 5448354 mce6D 4553759 mce6D Mycobacterium ulcerans Agy99 MCE-family protein Mce6D YP_908274.1 5447242 R 362242 CDS YP_908275.1 118619943 4553760 complement(5448351..5449397) 1 NC_008611.1 membrane protein; function unknown, but thought to be involved in host cell invasion.; MCE-family protein Mce6C 5449397 mce6C 4553760 mce6C Mycobacterium ulcerans Agy99 MCE-family protein Mce6C YP_908275.1 5448351 R 362242 CDS YP_908276.1 118619944 4553761 complement(5449390..5450418) 1 NC_008611.1 membrane protein; function unknown, but thought to be involved in host cell invasion.; MCE-family protein Mce6B 5450418 mce6B 4553761 mce6B Mycobacterium ulcerans Agy99 MCE-family protein Mce6B YP_908276.1 5449390 R 362242 CDS YP_908277.1 118619945 4553762 complement(5450482..5451972) 1 NC_008611.1 membrane protein; function unknown, but thought to be involved in host cell invasion.; MCE-family protein Mce6A 5451972 mce6A 4553762 mce6A Mycobacterium ulcerans Agy99 MCE-family protein Mce6A YP_908277.1 5450482 R 362242 CDS YP_908278.1 118619946 4553763 complement(5451975..5452841) 1 NC_008611.1 membrane protein; integral membrane protein YrbE6B 5452841 yrbE6B 4553763 yrbE6B Mycobacterium ulcerans Agy99 integral membrane protein YrbE6B YP_908278.1 5451975 R 362242 CDS YP_908279.1 118619947 4553764 complement(5452843..5453688) 1 NC_008611.1 membrane protein; integral membrane protein YrbE6A 5453688 yrbE6A 4553764 yrbE6A Mycobacterium ulcerans Agy99 integral membrane protein YrbE6A YP_908279.1 5452843 R 362242 CDS YP_908280.1 118619948 4551469 complement(5453698..5455350) 1 NC_008611.1 activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase 5455350 pks16_1 4551469 pks16_1 Mycobacterium ulcerans Agy99 long-chain-fatty-acid--CoA ligase YP_908280.1 5453698 R 362242 CDS YP_908281.1 118619949 4551470 complement(5455347..5455628) 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; thought to be involved in de novo fatty acid biosynthesis; this protein is the carrier of the growing fatty acid chain in fatty acid biosynthesis; acyl carrier protein 5455628 4551470 MUL_4923 Mycobacterium ulcerans Agy99 acyl carrier protein YP_908281.1 5455347 R 362242 CDS YP_908282.1 118619950 4551471 complement(5455644..5456420) 1 NC_008611.1 Detected in the membrane fraction by proteomics (2D- LC-MS/MS); membrane protein; hypothetical protein 5456420 4551471 MUL_4924 Mycobacterium ulcerans Agy99 hypothetical protein YP_908282.1 5455644 R 362242 CDS YP_908283.1 118619951 4551472 complement(5456417..5457391) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS) Also detected in the cytoplamic and extracellular matrix fractions.; membrane protein; probably involved in active transport of substrate across the membrane (export) responsible for energy coupling to the transport system.; ATP-binding protein ABC transporter 5457391 4551472 MUL_4925 Mycobacterium ulcerans Agy99 ATP-binding protein ABC transporter YP_908283.1 5456417 R 362242 CDS YP_908284.1 118619952 4551473 complement(5457366..5458094) 1 NC_008611.1 Also detected in the cytoplamic, the extracellular matrix and the membrane fractions by proteomics.; membrane protein; hypothetical protein 5458094 4551473 MUL_4926 Mycobacterium ulcerans Agy99 hypothetical protein YP_908284.1 5457366 R 362242 CDS YP_908285.1 118619953 4551474 complement(5458106..5458612) 1 NC_008611.1 Detected in cytoplasmic and membrane fraction by proteomics.; cytoplasmic protein; hypothetical protein 5458612 4551474 MUL_4927 Mycobacterium ulcerans Agy99 hypothetical protein YP_908285.1 5458106 R 362242 CDS YP_908286.1 118619954 4551475 complement(5458609..5459352) 1 NC_008611.1 Detected in the membrane fraction by proteomics (2D- LC-MS/MS); cytoplasmic protein; hypothetical protein 5459352 4551475 MUL_4928 Mycobacterium ulcerans Agy99 hypothetical protein YP_908286.1 5458609 R 362242 CDS YP_908287.1 118619955 4551476 complement(5459349..5460857) 1 NC_008611.1 Detected in the cytoplamic fraction by LC-MS/MS. Also detected in the extracellular matrix and membrane fraction by proteomics.; cytoplasmic protein; catalyzes the production of GabA [catalytic activity: L-glutamate = 4-aminobutanoate + CO(2)]; glutamate decarboxylase 5460857 4551476 MUL_4929 Mycobacterium ulcerans Agy99 glutamate decarboxylase YP_908287.1 5459349 R 362242 CDS YP_908288.1 118619956 4551477 complement(5460854..5462203) 1 NC_008611.1 Detected in the membrane fraction by proteomics.; cytoplasmic protein; 4-aminobutyrate aminotransferase, GabT_2 5462203 gabT_2 4551477 gabT_2 Mycobacterium ulcerans Agy99 4-aminobutyrate aminotransferase, GabT_2 YP_908288.1 5460854 R 362242 CDS YP_908289.1 118619957 4551478 complement(5462203..5463300) 1 NC_008611.1 membrane protein; function unknown.; hypothetical protein 5463300 4551478 MUL_4931 Mycobacterium ulcerans Agy99 hypothetical protein YP_908289.1 5462203 R 362242 CDS YP_908290.1 118619958 4551479 complement(5463297..5464277) 1 NC_008611.1 Detected in the membrane fraction by proteomics.; membrane protein; function unknown, probably involved in cellular metabolism.; nucleoside-diphosphate-sugar epimerases 5464277 4551479 MUL_4932 Mycobacterium ulcerans Agy99 nucleoside-diphosphate-sugar epimerases YP_908290.1 5463297 R 362242 CDS YP_908291.1 118619959 4551480 complement(5464277..5465458) 1 NC_008611.1 Also detected in the membrane fraction by proteomics.; cytoplasmic protein; hypothetical protein 5465458 4551480 MUL_4933 Mycobacterium ulcerans Agy99 hypothetical protein YP_908291.1 5464277 R 362242 CDS YP_908292.1 118619960 4551481 complement(5465451..5466539) 1 NC_008611.1 membrane protein; hypothetical protein 5466539 4551481 MUL_4934 Mycobacterium ulcerans Agy99 hypothetical protein YP_908292.1 5465451 R 362242 CDS YP_908293.1 118619961 4551482 5466914..5467639 1 NC_008611.1 membrane protein; hypothetical protein 5467639 4551482 MUL_4935 Mycobacterium ulcerans Agy99 hypothetical protein YP_908293.1 5466914 D 362242 CDS YP_908294.1 118619962 4551483 5467684..5468442 1 NC_008611.1 secreted protein; function unknown. possibly secreted.; hypothetical protein 5468442 4551483 MUL_4936 Mycobacterium ulcerans Agy99 hypothetical protein YP_908294.1 5467684 D 362242 CDS YP_908295.1 118619963 4551484 5468945..5469268 1 NC_008611.1 membrane protein; hypothetical protein 5469268 4551484 MUL_4938 Mycobacterium ulcerans Agy99 hypothetical protein YP_908295.1 5468945 D 362242 CDS YP_908296.1 118619964 4551485 5469945..5472182 1 NC_008611.1 Also detected in the membrane fraction by proteomics (LC-MS/MS); cytoplasmic protein; involved in the krebs cycle [catalytic activity: isocitrate + NADP+ = 2-oxoglutarate + CO(2) + NADPH]; isocitrate dehydrogenase [NADP] Icd2 5472182 icd2 4551485 icd2 Mycobacterium ulcerans Agy99 isocitrate dehydrogenase [NADP] Icd2 YP_908296.1 5469945 D 362242 CDS YP_908297.1 118619965 4551486 5472296..5473420 1 NC_008611.1 cytoplasmic protein; possibly involved in camp synthesis [catalytic activity: ATP = 3',5'-cyclic AMP + diphosphate]; adenylate cyclase, CyaA 5473420 cyaA 4551486 cyaA Mycobacterium ulcerans Agy99 adenylate cyclase, CyaA YP_908297.1 5472296 D 362242 CDS YP_908298.1 118619966 4551488 5474796..5475851 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; function unknown, but possibly involvement in lipid degradation.; acyl-CoA dehydrogenase FadE36_1 5475851 fadE36_1 4551488 fadE36_1 Mycobacterium ulcerans Agy99 acyl-CoA dehydrogenase FadE36_1 YP_908298.1 5474796 D 362242 CDS YP_908299.1 118619967 4552266 complement(5475873..5476913) 1 NC_008611.1 cytoplasmic protein; function unknown, probably involved in cellular metabolism.; coenzyme F420-dependent oxidoreductase 5476913 4552266 MUL_4943 Mycobacterium ulcerans Agy99 coenzyme F420-dependent oxidoreductase YP_908299.1 5475873 R 362242 CDS YP_908300.1 118619968 4552267 complement(5476972..5477403) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 5477403 4552267 MUL_4944 Mycobacterium ulcerans Agy99 hypothetical protein YP_908300.1 5476972 R 362242 CDS YP_908301.1 118619969 4552268 5477531..5478097 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; hypothetical protein 5478097 4552268 MUL_4945 Mycobacterium ulcerans Agy99 hypothetical protein YP_908301.1 5477531 D 362242 CDS YP_908302.1 118619970 4552270 5479535..5480179 1 NC_008611.1 cytoplasmic protein; involved in transcriptional mechanism.; TetR family transcriptional regulator 5480179 4552270 MUL_4947 Mycobacterium ulcerans Agy99 TetR family transcriptional regulator YP_908302.1 5479535 D 362242 CDS YP_908303.1 118619971 4552271 5480184..5481395 1 NC_008611.1 Detected in the cytoplasmic fraction by proteomics. Also detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; function unknown, but involved in lipid degradation [catalytic activity: acyl-CoA + ETF = 2,3-dehydroacyl-CoA + reduced ETF]; acyl-CoA dehydrogenase FadE25_2 5481395 fadE25_2 4552271 fadE25_2 Mycobacterium ulcerans Agy99 acyl-CoA dehydrogenase FadE25_2 YP_908303.1 5480184 D 362242 CDS YP_908304.1 118619972 4552272 5481464..5482672 1 NC_008611.1 membrane protein; function unknown, glycosyltransferases, related to UDP-glucuronosyltransferase; glycosyltransferase 5482672 4552272 MUL_4949 Mycobacterium ulcerans Agy99 glycosyltransferase YP_908304.1 5481464 D 362242 CDS YP_908305.1 118619973 4552273 5482849..5483469 1 NC_008611.1 secreted protein; function unknown.; hypothetical protein 5483469 4552273 MUL_4950 Mycobacterium ulcerans Agy99 hypothetical protein YP_908305.1 5482849 D 362242 CDS YP_908306.1 118619974 4552274 complement(5483491..5484654) 1 NC_008611.1 cytoplasmic protein; ATPase 5484654 4552274 MUL_4951 Mycobacterium ulcerans Agy99 ATPase YP_908306.1 5483491 R 362242 CDS YP_908307.1 118619975 4552275 5484788..5485279 1 NC_008611.1 cytoplasmic protein; transcriptional regulator 5485279 4552275 MUL_4952 Mycobacterium ulcerans Agy99 transcriptional regulator YP_908307.1 5484788 D 362242 CDS YP_908308.1 118619976 4552276 5485310..5485726 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; hypothetical protein 5485726 4552276 MUL_4953 Mycobacterium ulcerans Agy99 hypothetical protein YP_908308.1 5485310 D 362242 CDS YP_908309.1 118619977 4552277 5485822..5486220 1 NC_008611.1 cytoplasmic protein; hypothetical protein 5486220 4552277 MUL_4954 Mycobacterium ulcerans Agy99 hypothetical protein YP_908309.1 5485822 D 362242 CDS YP_908310.1 118619978 4552278 5486251..5487462 1 NC_008611.1 membrane protein; possibly catalyzes the transfer of a great variety of lipids between membranes.; lipid-transfer protein Ltp1_1 5487462 ltp1_1 4552278 ltp1_1 Mycobacterium ulcerans Agy99 lipid-transfer protein Ltp1_1 YP_908310.1 5486251 D 362242 CDS YP_908311.1 118619979 4552279 complement(5487471..5488046) 1 NC_008611.1 Detected in the membrane fraction by proteomics (2D- LC-MS/MS); cytoplasmic protein; involved in transcriptional mechanism.; TetR family transcriptional regulator 5488046 4552279 MUL_4956 Mycobacterium ulcerans Agy99 TetR family transcriptional regulator YP_908311.1 5487471 R 362242 CDS YP_908312.1 118619980 4552280 5488361..5489227 1 NC_008611.1 cytoplasmic protein; hypothetical protein 5489227 4552280 MUL_4957 Mycobacterium ulcerans Agy99 hypothetical protein YP_908312.1 5488361 D 362242 CDS YP_908313.1 118619981 4552281 5489235..5491460 1 NC_008611.1 membrane protein; function unknown, but involved in lipid degradation.; acyl-CoA dehydrogenase FadE6_1 5491460 fadE6_1 4552281 fadE6_1 Mycobacterium ulcerans Agy99 acyl-CoA dehydrogenase FadE6_1 YP_908313.1 5489235 D 362242 CDS YP_908314.1 118619982 4552282 5491616..5492809 1 NC_008611.1 cytoplasmic protein; hypothetical protein 5492809 4552282 MUL_4959 Mycobacterium ulcerans Agy99 hypothetical protein YP_908314.1 5491616 D 362242 CDS YP_908315.1 118619983 4552283 complement(5492849..5493115) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 5493115 4552283 MUL_4960 Mycobacterium ulcerans Agy99 hypothetical protein YP_908315.1 5492849 R 362242 CDS YP_908316.1 118619984 4552284 complement(5493167..5494351) 1 NC_008611.1 membrane protein; intergral membrane protein 5494351 4552284 MUL_4961 Mycobacterium ulcerans Agy99 intergral membrane protein YP_908316.1 5493167 R 362242 CDS YP_908317.1 118619985 4551037 complement(5494510..5495229) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 5495229 4551037 MUL_4962 Mycobacterium ulcerans Agy99 hypothetical protein YP_908317.1 5494510 R 362242 CDS YP_908318.1 118619986 4551038 complement(5495239..5495598) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 5495598 4551038 MUL_4963 Mycobacterium ulcerans Agy99 hypothetical protein YP_908318.1 5495239 R 362242 CDS YP_908319.1 118619987 4551039 complement(5496012..5497058) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 5497058 4551039 MUL_4964 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_908319.1 5496012 R 362242 CDS YP_908320.1 118619988 4551043 5499699..5500184 1 NC_008611.1 Regulates the synthesis of nucleoside triphosphates for nucleic acid synthesis, CTP for lipid synthesis, and GTP for protein elongation; nucleoside diphosphate kinase regulator 5500184 4551043 MUL_4967 Mycobacterium ulcerans Agy99 nucleoside diphosphate kinase regulator YP_908320.1 5499699 D 362242 CDS YP_908321.1 118619989 4551044 5500244..5500684 1 NC_008611.1 membrane protein; hypothetical protein 5500684 4551044 MUL_4968 Mycobacterium ulcerans Agy99 hypothetical protein YP_908321.1 5500244 D 362242 CDS YP_908322.1 118619990 4551045 5500784..5502175 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; function unknown, probably involved in cellular metabolism.; oxidoreductase 5502175 4551045 MUL_4969 Mycobacterium ulcerans Agy99 oxidoreductase YP_908322.1 5500784 D 362242 CDS YP_908323.1 118619991 4551046 5502176..5502940 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; function unknown, supposed involved in cellular metabolism.; short chain dehydrogenase 5502940 4551046 MUL_4970 Mycobacterium ulcerans Agy99 short chain dehydrogenase YP_908323.1 5502176 D 362242 CDS YP_908324.1 118619992 4551047 5502943..5504907 1 NC_008611.1 membrane protein; hypothetical protein 5504907 4551047 MUL_4971 Mycobacterium ulcerans Agy99 hypothetical protein YP_908324.1 5502943 D 362242 CDS YP_908325.1 118619993 4551048 5504907..5508179 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; involved in the biosynthesis of the mycobacterial cell wall arabinan and resistance to ethambutol (Emb; dextro-2,2'-(ethylenediimino)-di-1-butanol) polymerizes arabinose into the arabinan of arabiogalactan [catalytic activity: UDP-L-arabinose + indol-3-ylacetyl-myo-inositol = UDP + indol-3-ylacetyl-myo-inositol L-arabinoside]; integral membrane indolylacetylinositol arabinosyltransferase EmbC 5508179 embC 4551048 embC Mycobacterium ulcerans Agy99 integral membrane indolylacetylinositol arabinosyltransferase EmbC YP_908325.1 5504907 D 362242 CDS YP_908326.1 118619994 4551049 5508389..5511730 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; involved in the biosynthesis of the mycobacterial cell wall arabinan and resistance to ethambutol (Emb; dextro-2,2'-(ethylenediimino)-di-1-butanol) polymerizes arabinose into the arabinan of arabiogalactan [catalytic activity: UDP-L-arabinose + indol-3-ylacetyl-myo-inositol = UDP + indol-3-ylacetyl-myo-inositol L-arabinoside]; integral membrane indolylacetylinositol arabinosyltransferase EmbA 5511730 embA 4551049 embA Mycobacterium ulcerans Agy99 integral membrane indolylacetylinositol arabinosyltransferase EmbA YP_908326.1 5508389 D 362242 CDS YP_908327.1 118619995 4551050 5511727..5514954 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; involved in the biosynthesis of the mycobacterial cell wall arabinan and resistance to ethambutol (Emb; dextro-2,2'-(ethylenediimino)-di-1-butanol) polymerizes arabinose into the arabinan of arabiogalactan [catalytic activity: UDP-L-arabinose + indol-3-ylacetyl-myo-inositol = UDP + indol-3-ylacetyl-myo-inositol L-arabinoside]; integral membrane indolylacetylinositol arabinosyltransferase EmbB 5514954 embB 4551050 embB Mycobacterium ulcerans Agy99 integral membrane indolylacetylinositol arabinosyltransferase EmbB YP_908327.1 5511727 D 362242 CDS YP_908328.1 118619996 4551051 complement(5515263..5516309) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 5516309 4551051 MUL_4975 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_908328.1 5515263 R 362242 CDS YP_908329.1 118619997 4551053 5517894..5518232 1 NC_008611.1 secreted protein; hypothetical protein 5518232 4551053 MUL_4978 Mycobacterium ulcerans Agy99 hypothetical protein YP_908329.1 5517894 D 362242 CDS YP_908330.1 118619998 4551054 5518375..5518842 1 NC_008611.1 membrane protein; hypothetical protein 5518842 4551054 MUL_4979 Mycobacterium ulcerans Agy99 hypothetical protein YP_908330.1 5518375 D 362242 CDS YP_908331.1 118619999 4552625 complement(5523988..5525538) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; key enzyme in the catabolic pathway of odd-chain fatty acids, isoleucine, threonine, methionine, and valine [catalytic activity: ATP + propionyl-CoA + CO(2) + H(2)O = ADP + orthophosphate + methylmalonyl-CoA]; propionyl-CoA carboxylase beta chain 4 AccD4_1 5525538 accD4_1 4552625 accD4_1 Mycobacterium ulcerans Agy99 propionyl-CoA carboxylase beta chain 4 AccD4_1 YP_908331.1 5523988 R 362242 CDS YP_908332.1 118620000 4552626 complement(5525568..5530919) 1 NC_008611.1 cytoplasmic protein; the enzyme responsible for the final condensation step in mycolic acid biosynthesis, bringing the short and long (mero) chains together.; polyketide synthase Pks13 5530919 pks13 4552626 pks13 Mycobacterium ulcerans Agy99 polyketide synthase Pks13 YP_908332.1 5525568 R 362242 CDS YP_908333.1 118620001 4552627 complement(5530942..5532849) 1 NC_008611.1 activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase 5532849 fadD32 4552627 fadD32 Mycobacterium ulcerans Agy99 long-chain-fatty-acid--CoA ligase YP_908333.1 5530942 R 362242 CDS YP_908334.1 118620002 4552628 complement(5533148..5534161) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); secreted protein; hypothetical protein 5534161 4552628 MUL_4985 Mycobacterium ulcerans Agy99 hypothetical protein YP_908334.1 5533148 R 362242 CDS YP_908335.1 118620003 4552629 complement(5534398..5535315) 1 NC_008611.1 Also detected in the membrane fraction by proteomics (2D-LC-MS/MS); secreted protein; involved in cell wall mycoloylation. proteins of the antigen 85 complex are responsible for the high affinity of mycobacteria to fibronectin. possesses a mycolyltransferase activity required for the biogenesis of trehalose dimycolate (cord factor), a dominant structure necessary for maintaining cell wall integrity.; secreted Mpt51/Mpb51 antigen protein FbpD 5535315 fbpD 4552629 fbpD Mycobacterium ulcerans Agy99 secreted Mpt51/Mpb51 antigen protein FbpD YP_908335.1 5534398 R 362242 CDS YP_908336.1 118620004 4552630 complement(5535479..5536492) 1 NC_008611.1 Also detected in the membrane fraction by proteomics (2D-LC-MS/MS); secreted protein; involved in cell wall mycoloylation. proteins of the antigen 85 complex are responsible for the high affinity of mycobacteria to fibronectin. possesses a mycolyltransferase activity required for the biogenesis of trehalose dimycolate (cord factor), a dominant structure necessary for maintaining cell wall integrity.; secreted antigen 85-A FbpA 5536492 fbpA 4552630 fbpA Mycobacterium ulcerans Agy99 secreted antigen 85-A FbpA YP_908336.1 5535479 R 362242 CDS YP_908337.1 118620005 4552631 complement(5536909..5538828) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; transmembrane protein 5538828 4552631 MUL_4989 Mycobacterium ulcerans Agy99 transmembrane protein YP_908337.1 5536909 R 362242 CDS YP_908338.1 118620006 4552632 complement(5538875..5539783) 1 NC_008611.1 catalyzes the formation of decaprenylphosphoryl-5-phosphoribose from phosphoribose diphosphate and decaprenyl phosphate; phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase 5539783 4552632 MUL_4990 Mycobacterium ulcerans Agy99 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase YP_908338.1 5538875 R 362242 CDS YP_908339.1 118620007 4552633 complement(5539780..5540325) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; transmembrane protein 5540325 4552633 MUL_4991 Mycobacterium ulcerans Agy99 transmembrane protein YP_908339.1 5539780 R 362242 CDS YP_908340.1 118620008 4552634 complement(5540318..5542216) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; converts UDP-galactofuranose in cell wall galactan polymerization. has UDP-GalF:beta-D-(1->5) and UDP- GalF:beta-D-(1->6) galactofuranosyltransferase activities.; bifunctional UDP-galactofuranosyl transferase GlfT 5542216 glfT 4552634 glfT Mycobacterium ulcerans Agy99 bifunctional UDP-galactofuranosyl transferase GlfT YP_908340.1 5540318 R 362242 CDS YP_908341.1 118620009 4552635 complement(5542213..5543421) 1 NC_008611.1 cytoplasmic protein; involved in lipopolysaccharide biosynthesis, in the conversion of UDP-galactopyranose into UDP-galactofuranose through a 2-keto intermediate [catalytic activity: UDP-D- galactopyranose = UDP-D-galacto-1,4-furanose]; UDP-galactopyranose mutase Glf 5543421 glf 4552635 glf Mycobacterium ulcerans Agy99 UDP-galactopyranose mutase Glf YP_908341.1 5542213 R 362242 CDS YP_908342.1 118620010 4552636 5543710..5544636 1 NC_008611.1 secreted protein; surface-exposed protein required for multiplication and intracellular growth. seems to play a role in virulence.; exported repetitive protein precursor Erp 5544636 erp 4552636 erp Mycobacterium ulcerans Agy99 exported repetitive protein precursor Erp YP_908342.1 5543710 D 362242 CDS YP_908343.1 118620011 4552637 5544837..5546462 1 NC_008611.1 secreted protein; hypothetical protein 5546462 4552637 MUL_4995 Mycobacterium ulcerans Agy99 hypothetical protein YP_908343.1 5544837 D 362242 CDS YP_908344.1 118620012 4552638 complement(5546478..5547251) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 5547251 4552638 MUL_4996 Mycobacterium ulcerans Agy99 hypothetical protein YP_908344.1 5546478 R 362242 CDS YP_908345.1 118620013 4552394 complement(5547302..5548087) 1 NC_008611.1 cytoplasmic protein; function unknown, probably involved in cellular metabolism.; acyltransferase 5548087 4552394 MUL_4997 Mycobacterium ulcerans Agy99 acyltransferase YP_908345.1 5547302 R 362242 CDS YP_908346.1 118620014 4552395 complement(5548121..5548876) 1 NC_008611.1 cytoplasmic protein; function unknown, probably involved in cellular metabolism.; acyltransferase 5548876 4552395 MUL_4998 Mycobacterium ulcerans Agy99 acyltransferase YP_908346.1 5548121 R 362242 CDS YP_908347.1 118620015 4552396 complement(5548880..5549659) 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; function unknown, probably involved in cellular metabolism.; acyltransferase 5549659 4552396 MUL_4999 Mycobacterium ulcerans Agy99 acyltransferase YP_908347.1 5548880 R 362242 CDS YP_908348.1 118620016 4552397 5549732..5550562 1 NC_008611.1 cytoplasmic protein; function unknown, probably involved in cellular metabolism [catalytic activity: ATP + substrate = ADP + substrate 3'-phosphate]; phosphotransferase 5550562 4552397 MUL_5000 Mycobacterium ulcerans Agy99 phosphotransferase YP_908348.1 5549732 D 362242 CDS YP_908349.1 118620017 4552398 5550526..5552076 1 NC_008611.1 cytoplasmic protein; hypothetical protein 5552076 4552398 MUL_5001 Mycobacterium ulcerans Agy99 hypothetical protein YP_908349.1 5550526 D 362242 CDS YP_908350.1 118620018 4552399 5552073..5552405 1 NC_008611.1 cytoplasmic protein; hypothetical protein 5552405 4552399 MUL_5002 Mycobacterium ulcerans Agy99 hypothetical protein YP_908350.1 5552073 D 362242 CDS YP_908351.1 118620019 4552401 complement(5554005..5554652) 1 NC_008611.1 cytoplasmic protein; involved in transcriptional mechanism.; TetR family transcriptional regulator 5554652 4552401 MUL_5004 Mycobacterium ulcerans Agy99 TetR family transcriptional regulator YP_908351.1 5554005 R 362242 CDS YP_908352.1 118620020 4552402 5554734..5555216 1 NC_008611.1 membrane protein; hypothetical protein 5555216 4552402 MUL_5005 Mycobacterium ulcerans Agy99 hypothetical protein YP_908352.1 5554734 D 362242 CDS YP_908353.1 118620021 4552403 complement(5555213..5556472) 1 NC_008611.1 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; seryl-tRNA synthetase 5556472 serS 4552403 serS Mycobacterium ulcerans Agy99 seryl-tRNA synthetase YP_908353.1 5555213 R 362242 CDS YP_908354.1 118620022 4552404 5556631..5558007 1 NC_008611.1 membrane protein; hypothetical protein 5558007 4552404 MUL_5007 Mycobacterium ulcerans Agy99 hypothetical protein YP_908354.1 5556631 D 362242 CDS YP_908355.1 118620023 4552405 5558012..5558362 1 NC_008611.1 cytoplasmic protein; hypothetical protein 5558362 4552405 MUL_5008 Mycobacterium ulcerans Agy99 hypothetical protein YP_908355.1 5558012 D 362242 CDS YP_908356.1 118620024 4552406 complement(5558642..5559328) 1 NC_008611.1 cytoplasmic protein; thought to be involved in glycolisis and perhaps glycogen metabolism [catalytic activity: 3- phosphoglycerate = 2-phosphoglycerate]; phosphoglycerate mutase 5559328 4552406 MUL_5010 Mycobacterium ulcerans Agy99 phosphoglycerate mutase YP_908356.1 5558642 R 362242 CDS YP_908357.1 118620025 4552407 complement(5559325..5560272) 1 NC_008611.1 catalyzes the formation of phenylpyruvate from prephenate in phenylalanine biosynthesis; prephenate dehydratase 5560272 pheA 4552407 pheA Mycobacterium ulcerans Agy99 prephenate dehydratase YP_908357.1 5559325 R 362242 CDS YP_908358.1 118620026 4552408 5560368..5561168 1 NC_008611.1 cytoplasmic protein; hypothetical protein 5561168 4552408 MUL_5012 Mycobacterium ulcerans Agy99 hypothetical protein YP_908358.1 5560368 D 362242 CDS YP_908359.1 118620027 4552409 5561249..5562478 1 NC_008611.1 membrane protein; supposed involved in transcriptional mechanism.; transcriptional regulatory protein 5562478 4552409 MUL_5013 Mycobacterium ulcerans Agy99 transcriptional regulatory protein YP_908359.1 5561249 D 362242 CDS YP_908360.1 118620028 4552410 5562681..5563226 1 NC_008611.1 Also detected in the extracellular matrix and the membrane fraction by proteomics.; cytoplasmic protein; involved in iron storage; ferritin is an intracellular molecule that stores iron in a soluble, nontoxic, readily available form. the functional molecule, which is composed of 24 chains, is roughly spherical and contains a central cavity in which the polymeric ferric iron core is deposited.; bacterioferritin BfrB 5563226 bfrB 4552410 bfrB Mycobacterium ulcerans Agy99 bacterioferritin BfrB YP_908360.1 5562681 D 362242 CDS YP_908361.1 118620029 4552411 complement(5563223..5564068) 1 NC_008611.1 cytoplasmic protein; glycerophosphoryl diester phosphodiesterase hydrolyzes deacylated phospholipids to G3P and the corresponding alcohols [catalytic activity: a glycerophosphodiester + H(2)O = an alcohol + SN-glycerol 3- phosphate]; glycerophosphoryl diester phosphodiesterase GlpQ1 5564068 glpQ1 4552411 glpQ1 Mycobacterium ulcerans Agy99 glycerophosphoryl diester phosphodiesterase GlpQ1 YP_908361.1 5563223 R 362242 CDS YP_908362.1 118620030 4552412 complement(5564074..5565147) 1 NC_008611.1 membrane protein; hypothetical protein 5565147 4552412 MUL_5016 Mycobacterium ulcerans Agy99 hypothetical protein YP_908362.1 5564074 R 362242 CDS YP_908363.1 118620031 4552413 5565614..5565769 1 NC_008611.1 hypothetical protein 5565769 4552413 MUL_5017 Mycobacterium ulcerans Agy99 hypothetical protein YP_908363.1 5565614 D 362242 CDS YP_908364.1 118620032 4549650 5565918..5566541 1 NC_008611.1 Three isoforms were detected in the cytoplasm. Also detected in the extracellular matrix and the membrane fraction by proteomics.; cytoplasmic protein; destroys radicals which are normally produced within the cells and are toxic to biological systems [catalytic activity: 2 peroxide radical + 2 H(+) = O(2) + H(2)O(2)]; superoxide dismutase [Fe] SodA 5566541 sodA 4549650 sodA Mycobacterium ulcerans Agy99 superoxide dismutase [Fe] SodA YP_908364.1 5565918 D 362242 CDS YP_908365.1 118620033 4549651 5566875..5567291 1 NC_008611.1 membrane protein; hypothetical protein 5567291 4549651 MUL_5019 Mycobacterium ulcerans Agy99 hypothetical protein YP_908365.1 5566875 D 362242 CDS YP_908366.1 118620034 4549652 5567544..5568248 1 NC_008611.1 membrane protein; hypothetical protein 5568248 4549652 MUL_5020 Mycobacterium ulcerans Agy99 hypothetical protein YP_908366.1 5567544 D 362242 CDS YP_908367.1 118620035 4549653 5568711..5569109 1 NC_008611.1 Also detected in the membrane fraction by proteomics (2D-LC-MS/MS); cytoplasmic protein; hypothetical protein 5569109 4549653 MUL_5021 Mycobacterium ulcerans Agy99 hypothetical protein YP_908367.1 5568711 D 362242 CDS YP_908368.1 118620036 4549654 5569234..5569890 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; hypothetical protein 5569890 4549654 MUL_5022 Mycobacterium ulcerans Agy99 hypothetical protein YP_908368.1 5569234 D 362242 CDS YP_908369.1 118620037 4549655 5569963..5570214 1 NC_008611.1 secreted protein; hypothetical protein 5570214 4549655 MUL_5023 Mycobacterium ulcerans Agy99 hypothetical protein YP_908369.1 5569963 D 362242 CDS YP_908370.1 118620038 4549656 5570330..5570809 1 NC_008611.1 cytoplasmic protein; histone-like protein Hns 5570809 hns 4549656 hns Mycobacterium ulcerans Agy99 histone-like protein Hns YP_908370.1 5570330 D 362242 CDS YP_908371.1 118620039 4549657 5570813..5571310 1 NC_008611.1 regulator of RNase E; increases half-life and abundance of RNAs; interacts with RNase E possibly inhibiting catalytic activity; ribonuclease activity regulator protein RraA 5571310 menG 4549657 menG Mycobacterium ulcerans Agy99 ribonuclease activity regulator protein RraA YP_908371.1 5570813 D 362242 CDS YP_908372.1 118620040 4549658 complement(5571318..5572787) 1 NC_008611.1 cytoplasmic protein; activates the pro-drug ethionamide (eth); induced eth sensitivity when overexpressed in mycobacterium tuberculosis.; monooxygenase EthA 5572787 ethA 4549658 ethA Mycobacterium ulcerans Agy99 monooxygenase EthA YP_908372.1 5571318 R 362242 CDS YP_908373.1 118620041 4549659 5572863..5573510 1 NC_008611.1 cytoplasmic protein; regulates negatively the production of EthA. induced eth resistance when overexpressed in mycobacterium tuberculosis.; TetR family transcriptional regulator 5573510 ethR 4549659 ethR Mycobacterium ulcerans Agy99 TetR family transcriptional regulator YP_908373.1 5572863 D 362242 CDS YP_908374.1 118620042 4549660 5573452..5574741 1 NC_008611.1 involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function; DNA polymerase IV 5574741 dinP 4549660 dinP Mycobacterium ulcerans Agy99 DNA polymerase IV YP_908374.1 5573452 D 362242 CDS YP_908375.1 118620043 4549661 complement(5574730..5575737) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 5575737 4549661 MUL_5029 Mycobacterium ulcerans Agy99 hypothetical protein YP_908375.1 5574730 R 362242 CDS YP_908376.1 118620044 4549663 5576379..5576630 1 NC_008611.1 secreted protein; hypothetical protein 5576630 4549663 MUL_5031 Mycobacterium ulcerans Agy99 hypothetical protein YP_908376.1 5576379 D 362242 CDS YP_908377.1 118620045 4549664 5576834..5577526 1 NC_008611.1 Also detected in the cytoplasm by proteomics.; secreted protein; immunogenic protein Mpt64 5577526 mpt64 4549664 mpt64 Mycobacterium ulcerans Agy99 immunogenic protein Mpt64 YP_908377.1 5576834 D 362242 CDS YP_908378.1 118620046 4549665 complement(5577540..5578460) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 5578460 4549665 MUL_5033 Mycobacterium ulcerans Agy99 hypothetical protein YP_908378.1 5577540 R 362242 CDS YP_908379.1 118620047 4549666 5578724..5579575 1 NC_008611.1 cytoplasmic protein; hypothetical protein 5579575 4549666 MUL_5034 Mycobacterium ulcerans Agy99 hypothetical protein YP_908379.1 5578724 D 362242 CDS YP_908380.1 118620048 4549667 complement(5579649..5579759) 1 NC_008611.1 hypothetical protein 5579759 4549667 MUL_5035 Mycobacterium ulcerans Agy99 hypothetical protein YP_908380.1 5579649 R 362242 CDS YP_908381.1 118620049 4549668 complement(5579943..5581409) 1 NC_008611.1 glutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate; glutamate synthase subunit beta 5581409 gltD 4549668 gltD Mycobacterium ulcerans Agy99 glutamate synthase subunit beta YP_908381.1 5579943 R 362242 CDS YP_908382.1 118620050 4553624 complement(5581402..5585985) 1 NC_008611.1 cytoplasmic protein; probably involved in glutamate biosynthesis [catalytic activity: 2 L-glutamate + NADP(+) = L-glutamine + 2-oxoglutarate + NADPH]; ferredoxin-dependent glutamate synthase [NADPH] (large subunit) GltB 5585985 gltB 4553624 gltB Mycobacterium ulcerans Agy99 ferredoxin-dependent glutamate synthase [NADPH] (large subunit) GltB YP_908382.1 5581402 R 362242 CDS YP_908383.1 118620051 4553627 complement(5587407..5588453) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 5588453 4553627 MUL_5039 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_908383.1 5587407 R 362242 CDS YP_908384.1 118620052 4553628 complement(5588813..5590147) 1 NC_008611.1 cytoplasmic protein; required for the transposition of the insertion element IS2606.; transposase for IS2606 5590147 4553628 MUL_5040 Mycobacterium ulcerans Agy99 transposase for IS2606 YP_908384.1 5588813 R 362242 CDS YP_908385.1 118620053 4553633 complement(5598784..5599680) 1 NC_008611.1 membrane protein; hypothetical protein 5599680 4553633 MUL_5045 Mycobacterium ulcerans Agy99 hypothetical protein YP_908385.1 5598784 R 362242 CDS YP_908386.1 118620054 4553634 complement(5599703..5600749) 1 NC_008611.1 cytoplasmic protein; required for the transposition of insertion element IS2404.; transposase for IS2404 5600749 4553634 MUL_5046 Mycobacterium ulcerans Agy99 transposase for IS2404 YP_908386.1 5599703 R 362242 CDS YP_908387.1 118620055 4553636 complement(5601360..5602235) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 5602235 4553636 MUL_5048 Mycobacterium ulcerans Agy99 hypothetical protein YP_908387.1 5601360 R 362242 CDS YP_908388.1 118620056 4553637 5602769..5602996 1 NC_008611.1 cytoplasmic protein; hypothetical protein 5602996 4553637 MUL_5049 Mycobacterium ulcerans Agy99 hypothetical protein YP_908388.1 5602769 D 362242 CDS YP_908389.1 118620057 4553135 complement(5606957..5607229) 1 NC_008611.1 membrane protein; EsaT-6 like protein EsxE 5607229 esxE 4553135 esxE Mycobacterium ulcerans Agy99 EsaT-6 like protein EsxE YP_908389.1 5606957 R 362242 CDS YP_908390.1 118620058 4553136 complement(5607153..5607551) 1 NC_008611.1 membrane protein; EsaT-6 like protein EsxF 5607551 esxF 4553136 esxF Mycobacterium ulcerans Agy99 EsaT-6 like protein EsxF YP_908390.1 5607153 R 362242 CDS YP_908391.1 118620059 4553137 complement(5607662..5608150) 1 NC_008611.1 membrane protein; lipoprotein LppJ 5608150 lppJ 4553137 lppJ Mycobacterium ulcerans Agy99 lipoprotein LppJ YP_908391.1 5607662 R 362242 CDS YP_908392.1 118620060 4553138 complement(5608230..5610185) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 5610185 4553138 MUL_5057 Mycobacterium ulcerans Agy99 hypothetical protein YP_908392.1 5608230 R 362242 CDS YP_908393.1 118620061 4553139 complement(5610614..5610928) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 5610928 4553139 MUL_5058 Mycobacterium ulcerans Agy99 hypothetical protein YP_908393.1 5610614 R 362242 CDS YP_908394.1 118620062 4553141 complement(5611594..5613039) 1 NC_008611.1 cytoplasmic protein; involved in transcription mechanism [catalytic activity: N ATP + (nucleotide)(M) = N diphosphate + (nucleotide)(M+N)]; poly(a) polymerase PcnA 5613039 pcnA 4553141 pcnA Mycobacterium ulcerans Agy99 poly(a) polymerase PcnA YP_908394.1 5611594 R 362242 CDS YP_908395.1 118620063 4553142 5613205..5613951 1 NC_008611.1 cytoplasmic protein; hypothetical protein 5613951 4553142 MUL_5061 Mycobacterium ulcerans Agy99 hypothetical protein YP_908395.1 5613205 D 362242 CDS YP_908396.1 118620064 4553143 5613978..5616329 1 NC_008611.1 secreted protein; hypothetical protein 5616329 4553143 MUL_5062 Mycobacterium ulcerans Agy99 hypothetical protein YP_908396.1 5613978 D 362242 CDS YP_908397.1 118620065 4553144 5616446..5619988 1 NC_008611.1 Detected in the membrane fraction by proteomics (LC- MS/MS) Also detected in the cytoplasmic fraction by 2D-LC- MS/MS.; membrane protein; transmembrane protein 5619988 4553144 MUL_5063 Mycobacterium ulcerans Agy99 transmembrane protein YP_908397.1 5616446 D 362242 CDS YP_908398.1 118620066 4553145 5620050..5620637 1 NC_008611.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription: in Mycobacterium bovis this protein has been shown to be active at high temperatures and during stationary phase; RNA polymerase sigma factor SigM 5620637 sigM 4553145 sigM Mycobacterium ulcerans Agy99 RNA polymerase sigma factor SigM YP_908398.1 5620050 D 362242 CDS YP_908399.1 118620067 4553146 5620713..5621462 1 NC_008611.1 membrane protein; hypothetical protein 5621462 4553146 MUL_5065 Mycobacterium ulcerans Agy99 hypothetical protein YP_908399.1 5620713 D 362242 CDS YP_908400.1 118620068 4553147 5621552..5622550 1 NC_008611.1 Detected in the cytoplasmic fraction by 2D-LC- MS/MS. Also detected in the extracellular matrix and membrane fraction by proteomics.; cytoplasmic protein; enzyme that catalyse the reduction of disulphides by pyridine nucleotides through an enzyme disulphide and a flavin. seems regulated by SigH. [catalytic activity: NADPH + oxidized thioredoxin = NADP(+) + reduced thioredoxin]; thioredoxin reductase TrxB2 5622550 trxB2 4553147 trxB2 Mycobacterium ulcerans Agy99 thioredoxin reductase TrxB2 YP_908400.1 5621552 D 362242 CDS YP_908401.1 118620069 4553148 5622547..5622900 1 NC_008611.1 Detected in the cytoplamic, extracellular matrix and secreted fractions by proteomics.; cytoplasmic protein; thioredoxin participates in various redox reactions through the reversible oxidation of its active center dithiol, to a disulfide, & catalyzes dithiol-disulfide exchange reactions. forms together with thioredoxin reductase and NADPH a redox active system which donates electrons to a wide variety of different metabolic process (by similarity) seems regulated by SigH.; thioredoxin TrxC 5622900 trxC 4553148 trxC Mycobacterium ulcerans Agy99 thioredoxin TrxC YP_908401.1 5622547 D 362242 CDS YP_908402.1 118620070 4553149 5623032..5624252 1 NC_008611.1 cytoplasmic protein; function unknown, probably involved in cellular metabolism.; hydrolase 5624252 4553149 MUL_5068 Mycobacterium ulcerans Agy99 hydrolase YP_908402.1 5623032 D 362242 CDS YP_908403.1 118620071 4553150 complement(5624292..5625023) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 5625023 4553150 MUL_5069 Mycobacterium ulcerans Agy99 hypothetical protein YP_908403.1 5624292 R 362242 CDS YP_908404.1 118620072 4553151 complement(5625495..5626478) 1 NC_008611.1 Detected in the membrane fraction by proteomics. Also detected in the cytoplasmic fraction by 2D-LC-MS/MS.; secreted protein; involved in chromosome partition. localize to both poles of the predivisional cell following completion of DNA replication. binds to the DNA origin of replication (by similarity); chromosome partitioning protein ParB 5626478 parB 4553151 parB Mycobacterium ulcerans Agy99 chromosome partitioning protein ParB YP_908404.1 5625495 R 362242 CDS YP_908405.1 118620073 4553152 complement(5626475..5627449) 1 NC_008611.1 membrane protein; involved in chromosome partition. localize to both poles of the predivisional cell following completion of DNA replication (by similarity); chromosome partitioning protein ParA 5627449 parA 4553152 parA Mycobacterium ulcerans Agy99 chromosome partitioning protein ParA YP_908405.1 5626475 R 362242 CDS YP_908406.1 118620074 4551656 complement(5627780..5628292) 1 NC_008611.1 cytoplasmic protein; glucose-inhibited division protein B Gid 5628292 gid 4551656 gid Mycobacterium ulcerans Agy99 glucose-inhibited division protein B Gid YP_908406.1 5627780 R 362242 CDS YP_908407.1 118620075 4551657 complement(5628445..5628993) 1 NC_008611.1 domain identity suggests it is a Jag RNA-binding protein; Detected in the cytoplasmic fraction by 2D-LC- MS/MS. Also detected in the membrane fraction by proteomics (2D-LC-MS/MS); membrane protein; hypothetical protein 5628993 4551657 MUL_5073 Mycobacterium ulcerans Agy99 hypothetical protein YP_908407.1 5628445 R 362242 CDS YP_908408.1 118620076 4551658 complement(5629107..5630222) 1 NC_008611.1 functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria; putative inner membrane protein translocase component YidC 5630222 4551658 MUL_5074 Mycobacterium ulcerans Agy99 putative inner membrane protein translocase component YidC YP_908408.1 5629107 R 362242 CDS YP_908409.1 118620077 4551659 complement(5630206..5630514) 1 NC_008611.1 cytoplasmic protein; hypothetical protein 5630514 4551659 MUL_5075 Mycobacterium ulcerans Agy99 hypothetical protein YP_908409.1 5630206 R 362242 CDS YP_908410.1 118620078 4551660 complement(5630541..5630903) 1 NC_008611.1 protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates; ribonuclease P 5630903 rnpA 4551660 rnpA Mycobacterium ulcerans Agy99 ribonuclease P YP_908410.1 5630541 R 362242 CDS YP_908411.1 118620079 4551661 complement(5630927..5631070) 1 NC_008611.1 in Escherichia coli transcription of this gene is enhanced by polyamines; 50S ribosomal protein L34 5631070 rpmH 4551661 rpmH Mycobacterium ulcerans Agy99 50S ribosomal protein L34 YP_908411.1 5630927 R 362242 CDS