-- dump date   	20140619_155359
-- class       	Genbank::CDS
-- table       	cds_note
-- id	note
YP_025523.1	MUP001, rep, len: 368 aa. Probable rep, similar to the Rep proteins on several Mycobacterial plasmids e.g. O32860 Rep of the plasmid pJAZ38 from Mycobacterium fortuitum (see Gavigan et al., 1997) (368 aa), fasta scores: opt: 1692, E(): 1.7e-96, (68.306% identity in 366 aa overlap); and Q938A1 RepA of the plasmid pVT2 from Mycobacterium avium (391 aa), fasta scores: opt: 1283, E(): 2.6e-71, (55.556% identity in 360 aa overlap); and Q48888 Rep of the plasmid pLR7 from Mycobacterium avium (360 aa). Also weakly similar to Q9ZHK2 Putative replication protein of the plasmid pSOX from Rhodococcus sp. X309 (368 aa), fasta scores: opt: 272, E(): 4.1e-09, (36.022% identity in 372 aa overlap). Contains Prosite match to entry PS50310 Alanine-rich region.
YP_025524.1	MUP002c, -, len: 104 aa. Hypothetical protein.
YP_025525.1	MUP003, -, len: 198 aa. Hypothetical protein. Contains a helix turn helix motif between aa 30->51, Standard_deviations: 4.86, score 1665.00.
YP_025526.1	MUP004c, -, len: 204 aa. Hypothetical protein. An alternative start site exists at nt 2588.
YP_025527.1	MUP005c, parA, len: 326 aa. Possible parA, chromosome partitioning protein, similar to several e.g. O05189|PARA_CAUCR Chromosome partitioning protein parA from Caulobacter crescentus (267 aa), fasta scores: opt: 279, E(): 4.3e-10, (29.918% identity in 244 aa overlap); Q8G6J3|AAN24469 Chromosome partitioning protein P from Bifidobacterium longum (336 aa), fasta scores: opt: 324, E(): 7.3e-13, (30.085% identity in 236 aa overlap) and Q8KBD6 ATPase, ParA family from Chlorobium tepidum (265 aa), fasta scores: opt: 285, E(): 1.8e-10, (28.807% identity in 243 aa overlap). Contains a Pfam match to entry PF00991, ParA family ATPase.
YP_025528.1	MUP006c, -, len: 248 aa. Hypothetical protein.
YP_025529.1	MUP007c, -, len: 73 aa. Conserved hypothetical protein, some similarity to O33270|Rv0340 Hypothetical protein from M. tuberculosis (179 aa), fasta scores: opt: 88, E(): 21, (32.558% identity in 43 aa overlap); and Q8KKW1 Hypothetical protein on the symbiotic plasmid p42d from Rhizobium etli (108 aa), fasta scores: opt: 92, E(): 7.1, (58.333% identity in 24 aa overlap); and O52677 Core protein (Fragment) from Escherichia coli (193 aa), fasta scores: opt: 91, E(): 13, (31.818% identity in 66 aa overlap).
YP_025530.1	MUP008c, -, len: 182 aa. Possible nucleic acid binding protein, similar to the C-terminus of several N utilization substance proteins e.g. O05818|NUSA_MYCTU|Rv2841c N utilization substance protein A from M. tuberculosis (347 aa), fasta scores: opt: 337, E(): 6.5e-14, (42.143% identity in 140 aa overlap); Q9HV54 N utilization substance protein A from Pseudomonas aeruginosa (493 aa), fasta scores: opt: 353, E(): 7.9e-15, (38.255% identity in 149 aa overlap); etc. Contains a possible Pfam match to entry PF00013 KH domain.
YP_025531.1	MUP009, -, 142 aa. Hypothetical protein.
YP_025532.1	MUP010, -, len: 263 aa. Hypothetical protein.
YP_025533.1	MUP011, pknQ, len: 660 aa. Probable pknQ, transmembrane serine/threonine-protein kinase (EC 2.7.1.-), similar to several mycobacterial serine/threonine-protein kinases e.g. Q10697|PKNJ_MYCTU|Rv2088 from M. tuberculosis (589 aa), fasta scores: opt: 1121, E(): 2.9e-43, (43.45% identity in 527 aa overlap); P72003|PKNF_MYCTU|Rv1746 from M. tuberculosis (476 aa), fasta scores: opt: 761, E(): 4.2e-27, (38.661% identity in 463 aa overlap); Q9RLQ7 Putative serine/threonine protein kinase from M. bovis (291 aa), etc. And similar to serine/threonine-protein kinases from other bacteria e.g. Q9XA16 Putative serine/threonine protein kinase from Streptomyces coelicolor (673 aa), fasta scores: opt: 656, E(): 2.9e-22 (36.164% identity in 365 aa overlap). Contains a Prosite matches to entries PS50011 Protein kinase domain and PS00108, Serine/Threonine protein kinases active-site signature pattern. Belongs to the SER/THR family of protein kinases.
YP_025534.1	MUP012c, -, len: 87 aa. Hypothetical protein. Some similarity to Antigen 84 from M. tuberculosis and M. leprae e.g. P46816|AG84_MYCTU|Rv2145c Antigen 84 from M. tuberculosis (260 aa), fasta scores: opt: 105, E(): 4.1, (36.735% identity in 49 aa overlap).
YP_025535.1	MUP013c, -, len: 152 aa. Possible conserved membrane protein, some similarity to Q8EX03 Putative integral membrane protein from Mycoplasma penetrans (303 aa), fasta scores: opt: 106, E(): 14, (31.250% identity in 96 aa overlap). Contains two membrane spanning regions towards the N-terminus.
YP_025536.1	MUP014c, -, len: 257 aa. Putative integral membrane protein, contains several membrane spanning regions. An alternative start codon exists downstream.
YP_025537.1	MUP015c, -, len: 258 aa. Possible secreted protein, contains probable N-terminal signal sequence.
YP_025538.1	MUP016c, -, len: 263 aa. Hypothetical protein. Contains a Prosite match to entry PS00152 ATPASE_ALPHA_BETA ATP synthase alpha and beta subunits signature
YP_025539.1	MUP017c, -, len: 150 aa. Possible conserved transmembrane protein, weakly similar to O06254|Rv3437 possible conserved transmembrane protein from M. tuberculosis (158 aa), fasta scores: opt: 244, E(): 2.3e-05, (38.393% identity in 112 aa overlap). Contains a Prosite match to entry PS50099 PRO_RICH Proline-rich region. Contains hydrophobic region at the C-terminus.
YP_025540.1	MUP018c, -, len: 362 aa. Probable forkhead-associated protein, similar to several other M. tuberculosis conserved hypothetical ala-rich proteins e.g. P96214|Rv3863 Hypothetical protein (392 aa), fasta scores: opt: 525, E(): 1.9e-25, (33.602% identity in 372 aa overlap); O50389|Rv3360 Hypothetical protein (122 aa), fasta scores: opt: 198, E(): 3.4e-05, (37.113% identity in 97 aa overlap); and similar to the N-terminus of O65934|Rv1747 hypothetical 92.2 kDa protein (ABC transporter, ATP-binding protein (865 aa), fasta scores: opt: 207, E(): 4.3e-05, (37.255% identity in 102 aa overlap). Contains a Prosite match to entries PS50006 FHA_DOMAIN Forkhead-associated (FHA) domain and PS50310 ALA_RICH Alanine-rich region. And a Pfam match to entry PF01381 HTH_3, Helix-turn-helix.
YP_025541.1	MUP019, -, len: 344 aa. Probable conserved membrane protein, weakly similar to several membrane associated proteins from M. tuberculosis e.g. to the C-terminus of two probable serine/threonine-protein kinases Q11053|PKNH_MYCTU|Rv1266c (626 aa), fasta scores: opt: 483, E(): 3.7e-16, (29.032% identity in 341 aa overlap); and PKNJ_MYCTU|Q10697|Rv2088 (589 aa), fasta scores: opt: 315, E(): 5.4e-08, (25.649% identity in 308 aa overlap). Also weakly similar to P96858|Rv3576 Possible lipoprotein lppH from M. tuberculosis (237 aa), fasta scores: opt: 380, E(): 1.9e-11, (29.918% identity in 244 aa overlap). Contains a Prosite match to entry PS50099 PRO_RICH Proline-rich region. Contains a membrane spanning region between aa 102 to 124.
YP_025542.1	MUP020, -, len: 60 aa. Conserved hypothetical protein, some similarity to Q983E1 Hypothetical protein mll8367 from Rhizobium loti (Mesorhizobium loti) (91 aa), fasta scores: opt: 92, E(): 4.5, (35.00% identity in 40 aa overlap).
YP_025543.1	MUP021, -, len: 87 aa. Possible transcriptional regulatory protein, similar to other possible WhiB-like regulatory proteins e.g. O69649|Rv3681c Probable whiB4 from M. tuberculosis (118 aa), fasta scores: opt: 141, E(): 0.001, (44.681% identity in 47 aa overlap); P96215|Rv3862c Possible whiB6 from M. tuberculosis (116 aa), fasta scores: opt: 133, E(): 0.0054, (29.412% identity in 85 aa overlap). Also weakly similar to other putative regulatory proteins e.g. Q9S2B9 Putative regulatory protein from Streptomyces coelicolor (112 aa), fasta scores: opt: 115, E(): 0.11, (34.211% identity in 76 aa overlap). Contains a Pfam match to entry PF02467 Transcription factor WhiB.
YP_025544.1	MUP022, -, len: 444 aa. Probable transposase for IS2606, highly similar to Q9ZG97 Probable transposase from M. ulcerans (444 aa), fasta scores: opt: 2409, E(): 5.3e-154, (97.872% identity in 376 aa overlap); and similar to O05912 Hypothetical 48.7 kDa protein (IS1554, transposase) from M. tuberculosis (439 aa), fasta scores: opt: 1675, E(): 1.1e-104, (68.564% identity in 369 aa overlap).
YP_025545.1	MUP023c, -, len: 210 aa. Hypothetical protein.
YP_025546.1	MUP024c, -, len: 195 aa. Hypothetical protein.
YP_025547.1	MUP025, -, len: 579 aa. Putative transposase, weakly similar to several putative transposases e.g. Q8R6J9 Transposase from Thermoanaerobacter tengcongensis (565 aa), fasta scores: opt: 315, E(): 5.2e-13, (22.095% identity in 525 aa overlap); O70063 Putative transposase from Mycobacterium smegmatis (503 aa), fasta scores: opt: 221, E(): 9.3e-07, (26.190% identity in 504 aa overlap); Q9Z681 Transposase from Mycoplasma mycoides subsp. mycoides SC (483 aa), fasta scores: opt: 221, E(): 9e-07, (23.288% identity in 365 aa overlap). Almost identical to MUP028 and highly similar to MUP037 but longer.
YP_025548.1	MUP026, -, len: 444 aa. Probable transposase for IS2606, highly similar to Q9ZG97 Probable transposase from M. ulcerans (444 aa), fasta scores: opt: 2874, E(): 3.8e-192, (98.423% identity in 444 aa overlap); and similar to O05912 Hypothetical 48.7 kDa protein (IS1554, transposase) from M. tuberculosis (439 aa), fasta scores: opt: 2063, E(): 1.1e-135, (71.034% identity in 435 aa overlap).
YP_025549.1	MUP027c, -, len: 272 aa. Putative transposase, similar to several putative transposases e.g. P71924|Rv2424c Probable transposase for IS1558 from Mycobacterium tuberculosis (333 aa), fasta scores: opt: 755, E(): 1.7e-42, (45.118% identity in 297 aa overlap); Q8RAU1 Transposase from Thermoanaerobacter tengcongensis (405 aa), fasta scores: opt: 756, E(): 1.7e-42, (42.517% identity in 294 aa overlap). Contains a Pfam match to entry PF02371, Transposase IS116/IS110/IS902 family.
YP_025550.1	MUP028c, -, len: 579 aa. Putative transposase, weakly similar to several putative transposases e.g. Q8R6J9 Transposase from Thermoanaerobacter tengcongensis (565 aa), fasta scores: opt: 315, E(): 6.8e-13, (22.095% identity in 525 aa overlap); O70063 Putative transposase from Mycobacterium smegmatis (503 aa), fasta scores: opt: 221, E(): 1.1e-06, (26.190% identity in 504 aa overlap); Q9Z681 Transposase from Mycoplasma mycoides subsp. mycoides SC (483 aa), fasta scores: opt: 221, E(): 1.1e-06, (23.288% identity in 365 aa overlap). Almost identical to MUP025 and highly similar to MUP037 but longer.
YP_025551.1	MUP029c, -, len: 113 aa. Probable IS2404 transposase fragment, highly similar to the C-terminus of O07439 Putative transposase from Mycobacterium ulcerans (327 aa), fasta scores: opt: 496, E(): 3.7e-31, (94.805% identity in 77 aa overlap). Note that this homology extends across the upstream TAG stop codon into the upstream MUP030, suggesting a possible readthrough of the previous stop codon. No sequence errors have been identified and this insertion sequence containing the internal stop codon is repeated at two other locations on the plasmid, MUP047 + MUP048 and MUP062 + MUP063.
YP_025552.1	MUP030c, -, len: 234 aa. Probable IS2404 transposase fragment, highly similar to O07439 Putative transposase from Mycobacterium ulcerans (327 aa), fasta scores: opt: 1839, E(): 2.4e-119, (92.949% identity in 312 aa overlap). Note that this homology extends across the stop codon and directly into MUP029, suggesting a possible readthrough of the TAG stop codon. No sequence errors have been identified and this insertion sequence containing the internal stop codon is repeated at two other locations on the plasmid, MUP047 + MUP048 and MUP062 + MUP063.
YP_025553.1	MUP031c, -, len: 444 aa. Probable transposase for IS2606, highly similar to Q9ZG97 Probable transposase from Mycobacterium ulcerans (444 aa), fasta scores: opt: 2879, E(): 6.2e-188, (98.423% identity in 444 aa overlap); and to O05912 Hypothetical 48.7 kDa protein (IS1554, transposase) from M. tuberculosis (439 aa), fasta scores: opt: 2055, E(): 5e-132, (70.805% identity in 435 aa overlap).
YP_025554.1	MUP032c, mlsB, len: 14130 aa. Type I modular polyketide synthase, composed of a loading module and seven extender modules; required for the synthesis of the mycolactone side-chain in M. ulcerans (see Stinear et al., 2003). Similar to the modules in several other bacterial polyketide synthases e.g. Q93NX9 AmphI from Streptomyces nodosus (9510 aa), fasta scores: opt: 10163, E(): 0, (41.418% identity in 10394 aa overlap); Q9ALM3 Polyketide synthase extender modules 5-7 from Saccharopolyspora spinosa (4928 aa), fasta scores: opt: 8980, E(): 0, (46.330% identity in 4945 aa overlap); Q93HJ2 Modular polyketide synthase from Streptomyces avermitilis (4685 aa), fasta scores: opt: 5558, E(): 0, (44.649% identity in 4934 aa overlap). Contains 8 x Pfam matches to entry PF00109 ketoacyl-synt: Beta-ketoacyl synthase, N-terminal domain and 8 x Pfam matches to entry PF02801 ketoacyl-synt_C: Beta-ketoacyl synthase, C-terminal domain. Contains 8 x Pfam matches to entry PF00550 pp-binding: Phosphopantetheine attachment site and 8 x Pfam matches to entry PF00698 Acyl_transf: Acyl transferase domain.
YP_025555.1	MUP033c, -, len: 124 aa. Putative transposase, similar in part to several transposases e.g. BAC67824 Putative transposase from Streptomyces avermitilis (239 aa), fasta scores: opt: 263, E(): 3.7e-12, (50.617% identity in 81 aa overlap); Q8KRD5 ISRh1 transposase-like protein from Rhodococcus erythropolis (236 aa), fasta score: opt: 257, E(): 1e-11, (64.286% identity in 56 aa overlap); Q982I3 Transposase from plasmid pMLa of Rhizobium loti (Mesorhizobium loti) (185 aa), fasta scores: opt: 200, E(): 1.6e-07, (37.209% identity in 86 aa overlap). Highly similar to MUP041.
YP_025556.1	MUP034c, -, len: 179 aa. Putative transposase, weakly similar to several transposases from Xanthomonas e.g. Q8NL03 ISxac2 transposase from plasmid pXAC33 and pXAC64 of Xanthomonas axonopodis (275 aa), fasta scores: opt: 214, E(): 5.5e-07, (33.766% identity in 146 aa overlap); Q8PCU3 ISxcC1 transposase from Xanthomonas campestris (255 aa), fasta scores: opt: 198, E(): 3.8e-06, (34.286% identity in 105 aa overlap). Also weakly similar to Q9X9H9 IS1400 transposase B from Yersinia enterocolitica (294 aa), fasta scores: opt: 202, E(): 2.8e-06, (38.095% identity in 105 aa overlap). Almost identical to MUP042. Contains a Pfam match to entry PF00665 rve Integrase core domain.
YP_025557.1	MUP035, -, len: 237 aa. Putative transposase, similar to several transposases from Streptomyces e.g. BAC68344|Q82Q86 Putative transposase from Streptomyces avermitilis (354 aa), fasta scores: opt: 551, E(): 5.1e-23, (52.299% identity in 174 aa overlap); O69923 Putative transposase from Streptomyces coelicolor (379 aa), fasta score: opt: 309, E(): 7.6e-10, (35.897% identity in 195 aa overlap). And also weakly similar to BAC18219|Q8FPT1 Putative transposase from Corynebacterium efficiens (446 aa), fasta scores: opt: 435, E(): 8.5e-17, (39.487% identity in 195 aa overlap);and O07182|Rv0797 Putative transposase of IS1547 from M. tuberculosis (364 aa), fasta scores: opt: 225, E(): 3.5e-05, (31.818% identity in 154 aa overlap). Highly similar to MUP043 but shorter. Contains a Pfam match to entry PF01548 Transposase_9, Transposase.
YP_025558.1	MUP036c, -, len: 444 aa. Probable transposase for IS2606, highly similar to Q9ZG97 Probable transposase from Mycobacterium ulcerans (444 aa), fasta scores: opt: 2878, E(): 5.8e-191, (98.198% identity in 444 aa overlap); and to O05912 Hypothetical 48.7 kDa protein (IS1554, transposase) from M. tuberculosis (439 aa), fasta scores: opt: 2042, E(): 2.3e-134, (71.628% identity in 435 aa overlap).
YP_025559.1	MUP037, -, len: 451. Putative transposase, weakly similar to several transposases from Thermoanaerobacter tengcongensis e.g. Q8R7J7 Transposase (565 aa), fasta scores: opt: 296, E(): 1.8e-10, (22.826% identity in 368 aa overlap); and Q8R6J9 Transposase (565 aa), fasta scores: opt: 292, E(): 3.5e-10, (22.283% identity in 368 aa overlap). And also weakly similar to O70063 Putative transposase from Mycobacterium smegmatis (503 aa), fasta scores: opt: 203, E(): 9.1e-05, (26.790% identity in 377 aa overlap). And highly similar to MUP025 and MUP028 but shorter.
YP_025560.1	MUP038c, -, len: 301 aa. Possible thioesterase, similar to AAO65353|Q84CJ0 LanU-like protein from Streptomyces murayamaensis (249 aa), fasta scores: opt: 558, E(): 6.4e-30, (37.945% identity in 253 aa overlap); and weakly similar to weakly similar to Q98NH0 Lactone-specific esterase from Rhizobium loti (Mesorhizobium loti) (334 aa), fasta scores: opt: 175, E(): 0.00037, (23.675% identity in 283 aa overlap); Q9CD03|ML2603 Hypothetical protein from M. leprae (279 aa), fasta scores: opt: 153, E(): 0.0099, (33.051% identity in 118 aa overlap); Q9XAK3|SCO3599 Hypothetical protein from Streptomyces coelicolor (318 aa), fasta scores: opt: 160, E(): 0.0037, (28.261% identity in 276 aa overlap); and Q8PQF3 Hydrolase from Xanthomonas axonopodis (280 aa), fasta scores: opt: 158, E(): 0.0045, (30.769% identity in 130 aa overlap). Contains potential match to Pfam PF02230 Phospholipase/Carboxylesterase, Pfam PF00561 alpha/beta hydrolase fold.
YP_025561.1	MUP039c, mlsA2, len: 2410 aa. Type I modular polyketide synthase, composed of one extender module (module 9); required for the synthesis of the mycolactone core in M. ulcerans (see Stinear et al., 2003). Similar to part of several e.g. Q9S0R8 Type I polyketide synthase AVES 1 from Streptomyces avermitilis (3972 aa), fasta scores: opt: 3342, E(): 2.1e-187, (40.556% identity in 2160 aa overlap); Q93NW8 AmphA from Streptomyces nodosus (1412 aa), fasta scores: opt: 3171, E(): 9.9e-178, (47.163% identity in 1304 aa overlap). Contains a Pfam match to entry PF00109 ketoacyl-synt: Beta-ketoacyl synthase, N-terminal domain and a Pfam match to entry PF02801 ketoacyl-synt_C: Beta-ketoacyl synthase, C-terminal domain. Contains a Pfam match entry PF00550 pp-binding: Phosphopantetheine attachment site and a Pfam match to entry PF00698 Acyl_transf: Acyl transferase domain.
YP_025562.1	MUP040c, mlsA1, len: 16990 aa. Type I modular polyketide synthase, composed of a loading module and eight extender modules; required for the synthesis of the mycolactone core in M. ulcerans (see Stinear et al., 2003). Similar to the modules in several other bacterial polyketide synthases e.g. O33954 Tylactone synthase starter module and modules 1 & 2 from Streptomyces fradiae (4472 aa), fasta scores: opt: 5121, E(): 0, (41.958% identity in 4066 aa overlap); Q9ALM3 Polyketide synthase extender modules 5-7 from Saccharopolyspora spinosa (4928 aa), fasta scores: opt: 4860, E(): 0, (41.813% identity in 5515 aa overlap); and Q9ADL6 Soraphen polyketide synthase A from Polyangium cellulosum (6315 aa), fasta scores: opt: 4448, E(): 0, (39.533% identity in 6420 aa overlap). Contains 9 x Pfam matches to entry PF00109 ketoacyl-synt: Beta-ketoacyl synthase, N-terminal domain and 9 x Pfam match to entry PF02801 ketoacyl-synt_C: Beta-ketoacyl synthase, C-terminal domain. Contains 9 x Pfam match entry PF00550 pp-binding: Phosphopantetheine attachment site and 9 x Pfam match to entry PF00698 Acyl_transf: Acyl transferase domain.
YP_025563.1	MUP041c, -, len: 124 aa. Putative transposase, similar in part to several transposases e.g. BAC67824 Putative transposase from Streptomyces avermitilis (239 aa), fasta scores: opt: 263, E(): 3.7e-12, (50.617% identity in 81 aa overlap); Q8KRD5 ISRh1 transposase-like protein from Rhodococcus erythropolis (236 aa), fasta score: opt: 257, E(): 9e-12, (64.286% identity in 56 aa overlap); Q982I3 Transposase from plasmid pMLa of Rhizobium loti (Mesorhizobium loti) (185 aa), fasta scores: opt: 200, E(): 1.5e-07, (37.209% identity in 86 aa overlap). Highly similar to MUP033.
YP_025564.1	MUP042c, -, len: 179 aa. Putative transposase, weakly similar to several transposases from Xanthomonas e.g. Q8NL03 ISxac2 transposase from Xanthomonas axonopodis (275 aa), opt: 212, E(): 3.8e-07, (33.562% identity in 146 aa overlap); Q8PCU3 ISxcC1 transposase from Xanthomonas campestris (255 aa), fasta scores: opt: 198, E(): 3.4e-06, (34.286% identity in 105 aa overlap). Also weakly similar to Q9X9H9 IS1400 transposase B from Yersinia enterocolitica (294 aa), fasta scores: opt: 202, E(): 2e-06, (38.095% identity in 105 aa overlap). Almost identical to MUP034. Contains a Pfam match to entry PF00665 rve Integrase core domain.
YP_025565.1	MUP043, -, len: 351 aa. Putative transposase, similar to several putative transposases from Streptomyces e.g BAC68344|Q82Q86 Putative transposase from Streptomyces avermitilis (354 aa), fasta scores: opt: 1146, E(): 1.1e-63, (52.493% identity in 341 aa overlap); O69923 Putative transposase from Streptomyces coelicolor (379 aa), fasta scores: opt: 742, E(): 1.5e-38, (39.339% identity in 333 aa overlap). And similar to transposases from Corynebacterium efficiens e.g. BAC18308|Q8FTR3 Putative transposase (409 aa), fasta scores: opt: 993, E(): 4e-54, (45.210% identity in 334 aa overlap); BAC17059|Q8CMH0 Putative transposase (412 aa), fasta scores: opt: 947, E(): 2.9e-51, (43.413% identity in 334 aa overlap). Also weakly similar to Q8VJ30 IS1547, transposase from M. tuberculosis (596 aa), fasta scores: opt: 474, E(): 7.4e-22, (35.347% identity in 350 aa overlap). Contains a Pfam match to entry PF02371, Transposase_20, Transposase IS116/IS110/IS902 family. Highly similar to MUP035 but longer.
YP_025566.1	MUP044c, -, len: 46 aa. Putative truncated transposase, similar to several transposases from Xanthomonas e.g. Q8P9Q3 IS1477 transposase from Xanthomonas campestris (88 aa), fasta scores: opt: 106, E(): 0.2, (55.882% identity in 34 aa overlap); and Q8PRI1 ISxac2 transposase from Xanthomonas axonopodis (88 aa), fasta scores: opt: 104, E(): 0.29, (48.571% identity in 35 aa overlap). And some similarity to MUP051.
YP_025567.1	MUP045, -, len: 328 aa. Probable beta-ketoacyl synthase-like protein, weakly similar to Q9KHD3 Type III beta-ketoacyl synthase-like protein from Streptomyces griseus subsp. griseus (345 aa), fasta scores: opt: 238, E(): 1e-07, (26.282% identity in 312 aa overlap). Most similar to Q54816 Daunorubicin-doxorubicin polyketide synthase from Streptomyces peucetius (353 aa), fasta scores: opt: 301, E(): 9.1e-12, (31.672% identity in 341 aa overlap); and also similar to several 3-oxoacyl-(acyl-carrier-protein) synthases e.g. Q9A8I4 3-oxoacyl-(acyl-carrier-protein) synthase III from Caulobacter crescentus (322 aa), fasta scores: opt: 259, E(): 4.3e-09, (26.935% identity in 323 aa overlap).
YP_025568.1	MUP046, -, len: 97 aa. Possible membrane protein, some similarity to Q92RR3 Hypothetical protein R00794 from Rhizobium meliloti (275 aa), E(): 26, (36.634% identity in 101 aa overlap). Contains a membrane spanning region between aa 24 to 46.
YP_025569.1	MUP047, -, len: 234 aa. Probable IS2404 transposase fragment, highly similar to O07439 Putative transposase from Mycobacterium ulcerans (327 aa), fasta scores: opt: 1339, E(): 5.2e-84, (91.880% identity in 234 aa overlap). Note that this homology extends across the stop codon and directly into MUP048, suggesting a possible readthrough of the TAG stop codon. No sequence errors have been identified and this insertion sequence containing the internal stop codon is repeated at two other locations on the plasmid, MUP029 + MUP030 and MUP062 + MUP063.
YP_025570.1	MUP048, -, len: 113 aa. Probable IS2404 transposase fragment, highly similar to the C-terminus of O07439 Putative transposase from M. ulcerans (327 aa), fasta scores: opt: 496, E(): 6.8e-31, (94.80% identity in 77 aa overlap). Note that this homology extends across the upstream TAG stop codon into the upstream MUP047, suggesting a possible readthrough of the previous stop codon. No sequence errors have been identified and this insertion sequence containing the internal stop codon is repeated at two other locations on the plasmid, MUP029 + MUP030 and MUP062 + MUP063.
YP_025571.1	MUP049c, -, len: 129 aa. Putative transposase, similar to several e.g. Q54335 Similar to ORF1 of the IS3 family from Streptomyces lividans (103 aa), fasta scores: opt: 225, E(): 2.9e-07, (44.565% identity in 92 aa overlap); and Q8XFW6 transposase from Brucella melitensis (93 aa), fasta scores: opt: 207, E(): 3.7e-06, (38.043% identity in 92 aa overlap); Q98A50 Transposase from Rhizobium loti (Mesorhizobium loti) (98 aa), fasta scores: opt: 204, E(): 6e-06, (37.234% identity in 94 aa overlap); Q8UJV4 Transposase from Agrobacterium tumefaciens plasmid AT (strain C58 / ATCC 33970) (96 aa), fasta scores: opt: 199, E(): 1.2e-05, (37.634% identity in 93 aa overlap). Contains a Pfam match to entry PF01527 Transposase_8, Transposase. Contains a helix turn helix motif between aa 58->79, tandard_deviations: 5.30, Score 1795.000.
YP_025572.1	MUP050, -, len: 444 aa. Probable transposase for IS2606, highly similar to Q9ZG97 Probable transposase from Mycobacterium ulcerans (444 aa), fasta scores: opt: 2878, E(): 2.7e-186, (98.423% identity in 444 aa overlap); and to O05912 Hypothetical 48.7 kDa protein (IS1554, transposase) from M. tuberculosis (439 aa), fasta scores: opt: 2053, E(): 1.2e-130, (70.805% identity in 435 aa overlap).
YP_025573.1	MUP051, -, len: 93 aa. Putative transposase, similar to several transposases from Rhizobium loti (Mesorhizobium loti) e.g. Q8KHM1 Putative insertion element transposase protein (88 aa), fasta scores: opt: 254, E(): 2.3e-10, (48.889% identity in 90 aa overlap). And weakly similar to several transposases from Yersinia e.g. O68709 Putative transposase from Yersinia pestis (88 aa), fasta scores: opt: 234, E(): 5.3e-09, (37.778% identity in 90 aa overlap). And some similarity to MUP044. Contains a Pfam match to entry PF01527, Transposase_8, Transposase. Contains helix turn helix motif between aa 27->48, Standard_deviations: 4.91, score 1680.00.
YP_025574.1	MUP052, -, len: 277 aa. Putative transposase, weakly similar to several transposases e.g Q89TF0 Blr2054 protein from Bradyrhizobium japonicum (290 aa), fasta scores: E(): 1.9e-27, (38.224% identity in 259 aa overlap); Q8U751 IS3 family transposase from Agrobacterium tumefaciens (strain C58 / ATCC 33970) (309 aa), fasta scores: opt: 549, E(): 1.3e-29, (39.068% identity in 279 aa overlap); Q8KJC6 Putative transposase for insertion sequence from Rhizobium loti (Mesorhizobium loti) (309 aa), fasta scores: opt: 528, E(): 2.5e-25 (35.836% identity in 293 aa overlap). Contains a Pfam match to PF00665 rve, Integrase core domain and a PS50316 histidine-rich region.
YP_025575.1	MUP053c, cyp150, len: 437 aa. Probable cyp150, cytochrome p450 (EC 1.14.-.-), similar to O08464|C140_MYCTU|Rv1880c Probable cytochrome P450 140 from M. tuberculosis (438 aa), fasta scores: opt: 1873, E(): 6.7e-117, (62.529% identity in 435 aa overlap). And weakly similar to numerous others e.g. Q89G11|BAC51802 Bll6537 protein from Bradyrhizobium japonicum (433 aa), fasta scores: opt: 755, E(): 6.1e-41 (34.925% identity in 398 aa overlap); and Q9X8Q3 Putative cytochrome P450 from Streptomyces coelicolor (411 aa), fasta scores: E(): 2.9e-36, (34.063% identity in 411 aa overlap). Contains a Pfam match to entry PF00067, Cytochrome P450. Belongs to the cytochrome P450 family.
YP_025576.1	MUP054c, -, len: 167 aa. Possible integrase fragment, weakly similar to several e.g. AAO22922 Integrase/recombinase from Myxococcus xanthus (300 aa), fasta scores: opt: 176, E(): 0.00018, (37.4% identity in 107 aa overlap); Q8NNZ9 Integrase from Corynebacterium glutamicum (Brevibacterium flavum) (308 aa), fasta scores: opt: 169, E(): 0.00054, (33.33% identity in 84 aa overlap); and Q8L3A3 Putative integrase/recombinase Xer from Bacillus stearothermophilus (304 aa), fasta scores: opt: 168, E(): 0.00063, (33.02% identity in 106 aa overlap). Contains a Pfam match to entry PF00589 Phage_integrase Phage integrase family.
YP_025577.1	MUP055, -, len: 444 aa. Probable transposase for IS2606, highly similar to Q9ZG97 Probable transposase from Mycobacterium ulcerans (444 aa), fasta scores: opt: 2879, E(): 1.7e-184, (98.198% identity in 444 aa overlap); and to O05912 Hypothetical 48.7 kDa protein (IS1554, transposase) from M. tuberculosis (439 aa), fasta scores: opt: 2055, E(): 1.9e-129, (70.575% identity in 435 aa overlap).
YP_025578.1	MUP056c, -, len: 126 aa. Hypothetical protein.
YP_025579.1	MUP057c, -, len: 258 aa. Possible lipoprotein, weakly similar to Q49597 MK35 lipoprotein precursor from Mycobacterium kansasii (225 aa), fasta scores: opt: 139, E(): 0.21, (27.059% identity in 170 aa overlap); and weakly similar at the N-terminus to Q8XCD1 Hypothetical protein z2967 from Escherichia coli O157:H7 (115 aa), fasta scores: opt: 148, E(): 0.037, (29.167% identity in 96 aa overlap). Has signal peptide and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
YP_025580.1	MUP058c, -, len: 345 aa. Possible site-specific recombinase, weakly similar to several e.g. Q8U9U6 Site-specific recombinase from Agrobacterium tumefaciens (strain C58 / ATCC 33970) (331 aa), fasta scores: opt: 278, E(): 1.6e-11, (26.441% identity in 295 aa overlap)Q9JW14 Putative integrase/recombinase from Neisseria meningitidis (serogroup A) (305 aa), fasta scores: opt: 271, E(): 4.6e-11, (28.808% identity in 302 aa overlap); and O31206 Site-specific recombinase from Proteus mirabilis (313 aa), fasta scores: opt: 258, E(): 3.7e-10 (31.010% identity in 287 aa overlap). Contains Pfam match entries to PF02899 Phage integrase and PF00589 Phage integrase family.
YP_025581.1	MUP059c, -, len: 348 aa. Probable transposase for IS2404, highly similar to O07439 Putative transposase from Mycobacterium ulcerans (327 aa), fasta scores: opt: 1839, E(): 2.4e-119, (92.949% identity in 312 aa overlap).
YP_025582.1	MUP060, -, len: 173 aa. Probable IS2606 transposase fragment, highly similar to the N-terminus of Q9ZG97 Probable transposase from Mycobacterium ulcerans (444 aa), fasta scores: opt: 886, E(): 1.8e-52, (84.615% identity in 169 aa overlap); and to the N-terminus of O05912 Hypothetical 48.7 kDa protein (IS1554, transposase) from M. tuberculosis (439 aa), fasta scores: opt: 506, E(): 1.1e-26, (60.000% identity in 135 aa overlap). The transposase described here may be made by a frame shifting mechanism during translation that fuses MUP060 and MUP061, no sequence errors have been identified to account for this.
YP_025583.1	MUP061, -, len: 302 aa. Probable IS2606 transposase fragment, highly similar to the C-terminus of Q9ZG97 Probable transposase from Mycobacterium ulcerans (444 aa), fasta scores: opt: 1990, E(): 2.8e-132, (98.675% identity in 302 aa overlap); and to the C-terminus of O05912 Hypothetical 48.7 kDa protein (IS1554, transposase) from M. tuberculosis (439 aa), fasta scores: opt: 1544, E(): 6.9e-101, (75.166% identity in 302 aa overlap). The transposase described here may be made by a frame shifting mechanism during translation that fuses MUP060 and MUP061, no sequence errors have been identified to account for this.
YP_025584.1	MUP062, -, len: 234 aa. Probable IS2404 transposase fragment, highly similar to O07439 Putative transposase from M. ulcerans (327 aa), fasta scores: opt: 1333, E(): 2.7e-84, (91.880% identity in 234 aa overlap). Note that this homology extends across the stop codon and directly into MUP063, suggesting a possible readthrough of the TAG stop codon. No sequence errors have been identified and this insertion sequence containing the internal stop codon is repeated at two other locations on the plasmid, MUP029 + MUP030 and MUP047 + MUP048.
YP_025585.1	MUP063, -, len: 113 aa. Probable IS2404 transposase fragment, highly similar to the C-terminus of O07439 Putative transposase from M. ulcerans (327 aa), fasta scores: opt: 503, E(): 1.9e-31, (96.104% identity in 77 aa overlap). Note that this homology extends across the upstream TAG stop codon into the upstream MUP062, suggesting a possible readthrough of the previous stop codon. No sequence errors have been identified and this insertion sequence containing the internal stop codon is repeated at two other locations on the plasmid, MUP029 + MUP030 and MUP047 + MUP048.
YP_025586.1	MUP064c, -, len: 120 aa. Possible conserved membrane protein, shows some similarity with other putative membrane proteins e.g. C-terminus of O06345|Rv3482c Probable conserved membrane protein from M. tuberculosis (260 aa), fasta scores: opt: 129, E(): 0.39, (30.233% identity in 86 aa overlap). And show some similarity to Mycobacteriophage proteins e.g. AAN12600 Gp39 from Mycobacteriophage (132 aa), fasta score: E(): 0.055, (40.000% identity in 50 aa overlap). Contains several membrane spanning regions towards the C-terminus.
YP_025587.1	MUP065c, -, len: 293 aa. Conserved hypothetical protein, weakly similar at the N-terminus to several hypothetical proteins e.g. Q8U687 Hypothetical protein Atu6048 from Agrobacterium tumefaciens (strain C58 / ATCC 33970) (836 aa), fasta scores: opt: 223, E(): 8.2e-07, (30.000% identity in 170 aa overlap); and also some similarity at the N-terminus to several helicases e.g. AAO50170 Putative helicase from Streptomyces violaceoruber (866 aa), fasta scores: E(): 1.1e-09, (33.032% identity in 221 aa overlap); and P44701|SRMB_HAEIN ATP-dependent RNA helicase srmB homolog from Haemophilus influenzae (439 aa), fasta scores: opt: 124, E(): 1.9, (31.429% identity in 105 aa overlap). Contains a Pfam match to entry PF00270, DEAD/DEAD box helicase.
YP_025588.1	MUP066c, -, len: 168 aa. Conserved hypothetical protein, weakly similar to several bacteriophage-related proteins e.g. P03796|Y77_BPT7 Hypothetical gene 7.7 protein from Bacteriophage T7 (130 aa), fasta scores: opt: 171, E(): 0.0002, (32.075% identity in 106 aa overlap); and Q8XUF2 Putative bacteriophage-related protein from Ralstonia solanacearum (Pseudomonas solanacearum) (183 aa), fasta scores: opt: 163, E(): 0.00089, (32.773% identity in 119 aa overlap). Contains a Prosite match to entry PS00029 LEUCINE_ZIPPER Leucine zipper pattern.
YP_025589.1	MUP067c, -, len: 210 aa. Conserved hypothetical protein, weak similarity to N-terminus of spermidine synthases e.g. Q82EU4 Putative spermidine synthase from Streptomyces avermitilis (548 aa), FASTA scores: opt: 124, E(): 2.5, (34.091% identity in 88 aa overlap); and weak similarity to N-terminus of O87639|SCO3941 Putative serine/threonine phosphatase from Streptomyces coelicolor (368 aa), fasta scores: opt: 112, E(): 12, (27.919% identity in 197 aa overlap).
YP_025590.1	MUP068c, -, len: 376 aa. Conserved membrane protein, similar to several Mycobacterial membrane proteins e.g. O53933|Rv1782 (506 aa) from M. tuberculosis, fasta scores: opt: 763, E(): 1.8e-34, (41.935% identity in 341 aa overlap); Q9Z5I3 Hypothetical 53.9 kDa protein (Conserved membrane protein) from M. leprae (506 aa), fasta scores: opt: 733, E(): 4.2e-32, (38.596% identity in 399 aa overlap); and the M. tuberculosis proteins Rv3895c, Rv0283, Rv3869 and Rv3450c. And also weakly similar to other bacterial hypothetical proteins e.g. Q8NSU6 Hypothetical protein Cgl0571 from Corynebacterium glutamicum (419 aa), fasta scores: opt: 349, E(): 4.3e-12, (31.818% identity in 242 aa overlap). Contains a Pfam match to entry PF05108 DUF690, protein of unknown function and a Prosite match to entry PS50310 alanine-rich region. Contains a possible N-terminal signal sequence.
YP_025591.1	MUP069c, -, len: 444 aa. Probable transposase for IS2606, highly similar to Q9ZG97 Probable transposase from Mycobacterium ulcerans (444 aa), fasta scores: opt: 2867, E(): 8e-184, (97.973% identity in 444 aa overlap); and to O05912 Hypothetical 48.7 kDa protein (IS1554, transposase) from M. tuberculosis (439 aa), fasta scores: opt: 2043, E(): 9.7e-129, (70.345% identity in 435 aa overlap).
YP_025592.1	MUP070c, -, len: 365 aa. Conserved hypothetical protein, weakly similar to part of Q9KYC4 Hypothetical protein SCO6906 from Streptomyces coelicolor (529 aa), fasta scores: opt: 185, E(): 0.0015, (27.305% identity in 282 aa overlap). Similarity to Q9KYC4 begins in the upstream CDS, and this could be accounted for by a frameshift, although the sequence has been checked and no discrepancy was found.
YP_025593.1	MUP071c, -, len: 138 aa. Conserved hypothetical protein, weakly similar to the N-terminus of Q9KYC4 Hypothetical protein SCO6906 from Streptomyces coelicolor (529 aa), fasta scores: opt: 153, E(): 0.0041, (29.060% identity in 117 aa overlap). Similarity to Q9KYC4 continues in the following CDS, and this could be accounted for by a frameshift, although the sequence has been checked and no discrepancy was found.
YP_025594.1	MUP072c, -, len: 398 aa. Conserved hypothetical protein, some similarity to proteins from Caenorhabditis elegans e.g. Q20739 F54B11.2 protein (304 aa), fasta scores: opt: 192, E(): 0.017, (39.216% identity in 102 aa overlap); and CAE11316 C. elegans COL-185 protein (305 aa), fasta scores: opt: 185, E(): 0.039, (38.235% identity in 102 aa overlap). Contains a Prosite match to entry PS50310 ALA_RICH Alanine-rich region.
YP_025595.1	MUP073c, -, len: 397 aa. Conserved hypothetical protein. Some similarity to part of Q9Z5I9|IF2_MYCLE|ML1556 Translation initiation factor IF-2 from M. leprae (924 aa), fasta scores: opt: 228, E(): 0.0023, (26.997% identity in 363 aa overlap). Contains a Prosite match to entry PS00015 NUCLEAR Bipartite nuclear targeting sequence.
YP_025596.1	MUP074c, -, len: 194 aa. Possible membrane protein, weakly similar to several bacterial membrane and hypothetical proteins e.g. O53200|Rv2473 Hypothetical protein from M. tuberculosis (238 aa), fasta scores: opt: 155, E(): 0.18, (25.248% identity in 202 aa overlap); O86726 Hypothetical protein SCO6544 from Streptomyces coelicolor (226 aa), fasta scores: opt: 155, E(): 0.18, (25.405% identity in 185 aa overlap). Contains a Prosite match to entry PS50310 ALA_RICH Alanine-rich region. Contains hydrophobic region in the N-terminus.
YP_025597.1	MUP075c, -, len: 112 aa. Hypothetical protein, some similarity to part of Q8Y3B8 Probable substrate-binding transmembrane protein from Ralstonia solanacearum (Pseudomonas solanacearum) (801 aa), fasta scores: opt: 131, E(): 1.1, (33.33% identity in 102 aa overlap). Contains a Prosite match to entry PS50310 ALA_RICH Alanine-rich region.
YP_025598.1	MUP076c, -, len: 223 aa. Possible membrane protein, contains a membrane spanning region between aa 57 to 79. Contains a Prosite match to entry PS50099 PRO_RICH Proline-rich region.
YP_025599.1	MUP077c, -, len: 130 aa. Conserved hypothetical protein, weakly similar to P71600|Y030_MYCTU|Rv0030 Hypothetical protein from M. tuberculosis (109 aa), fasta scores: opt: 122, E(): 0.42, (27.660% identity in 94 aa overlap); and O69744|Rv3880c Hypothetical protein from M. tuberculosis (115 aa), fasta scores: opt: 112, E(): 2.1, (29.000% identity in 100 aa overlap).
YP_025600.1	MUP078c, -, len: 527 aa. Conserved hypothetical protein, weakly similar to Q10691|YK83_MYCTU|Rv2083 Hypothetical protein from M. tuberculosis (314 aa), fasta scores: opt: 229, E(): 0.0041, (32.597% identity in 181 aa overlap); Q8WTL8 Hypothetical 37.7 kDa protein from Caenorhabditis elegans (435 aa), fasta scores: opt: 233, E(): 0.0034, (32.093% identity in 215 aa overlap); and also weakly similar to several PGRS-family proteins e.g. O53884|Rv0872c|PE_PGRS15 PGRS-family protein from M. tuberculosis (606 aa), fasta scores: opt: 220, E(): 0.016, (25.686% identity in 510 aa overlap). Contains a Prosite match to entry PS00029 LEUCINE_ZIPPER Leucine zipper pattern.
YP_025601.1	MUP079c, -, len: 99 aa. Conserved hypothetical protein, weakly similar to P71598|Y028_MYCTU|Rv0028 Hypothetical protein from M. tuberculosis (101 aa), fasta scores: opt: 93, E(): 11, (32.558% identity in 86 aa overlap); and some similarity to Q51652 DNA primase (Fragment) from Escherichia coli (489 aa), fasta scores: opt: 101, E(): 11, (29.762% identity in 84 aa overlap).
YP_025602.1	MUP080c, -, len: 90 aa. Conserved hypothetical protein, weakly similar to P71597|Y027_MYCTU|Rv0027 Hypothetical protein from M. tuberculosis (105 aa), fasta scores: opt: 117, E(): 0.3, (26.966% identity in 89 aa overlap).
YP_025603.1	MUP081c, -, len: 514 aa. Conserved hypothetical protein, weakly similar to P71596|YO26_MYCTU|Rv0026 Hypothetical protein from M. tuberculosis (448 aa), fasta scores: opt: 501 E(): 6.9e-15, (31.989% identity in 372 aa overlap). Contains a Prosite match to entry PS00017 ATP_GTP_A- ATP/GTP-binding site motif A (P-loop).
YP_904252.1	binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself.
YP_904253.1	binds the polymerase to DNA and acts as a sliding clamp
YP_904254.1	Required for DNA replication; binds preferentially to single-stranded, linear DNA
YP_904255.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein
YP_904256.1	negatively supercoils closed circular double-stranded DNA
YP_904257.1	negatively supercoils closed circular double-stranded DNA
YP_904258.1	membrane protein
YP_904259.1	cytoplasmic protein
YP_904260.1	cytoplasmic protein; transcription
YP_904261.1	cytoplasmic protein
YP_904262.1	Also detected in the extracellular matrix by proteomics.; cytoplasmic protein; Ppiases accelerate the folding of proteins [catalytic activity: cis-trans isomerization of proline imidic peptide bonds in oligopeptides]
YP_904263.1	membrane protein
YP_904264.1	integral membrane protein involved in inhibition of the Z-ring formation
YP_904265.1	membrane protein
YP_904266.1	aminodeoxychorismate synthase subunit PabA; with PabB catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine in para-aminobenzoate synthesis; PabA provides the glutamine amidotransferase activity
YP_904267.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; involved in signal transduction (via phosphorylation) thought to regulate cell division/differentiation. can phosphorylate the peptide substrate myelin basic protein (MBP) [catalytic activity: ATP + a protein = ADP + a phosphoprotein]
YP_904268.1	membrane protein; involved in signal transduction (via phosphorylation) thought to regulate morphological changes associated with cell division/differentiation process. phosphorylates at serine and threonine residues [catalytic activity: ATP + a protein = ADP + a phosphoprotein]
YP_904269.1	membrane protein; involved in peptidoglycan synthesis (at the final stages) cell wall formation; PbpA is supposed to be responsible for the determination of the rod shape of the cell. its synthesizes cross-linked peptidoglycan from lipid intermediates.
YP_904270.1	membrane protein; this is a septum-peptidoglycan biosynthetic protein, involved in cell wall formation. plays a role in the stabilization of the FtsZ ring during cell division.
YP_904271.1	Detected in the membrane fraction by proteomics (LC- MS/MS) Also detected in the cytoplasmic fraction by 2D-LC- MS/MS.; membrane protein; involved in regulation (using dephosphorylation of a specific phosphorylated substrate)
YP_904272.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_904273.1	Detected in the cytoplasmic and secreted fractions by 2D-LC-MS/MS.; secreted protein; function unknown, contains FHA domain
YP_904274.1	cytoplasmic protein; required for the transposition of the insertion element IS2606.
YP_904275.1	cytoplasmic protein
YP_904276.1	cytoplasmic protein
YP_904277.1	cytoplasmic protein
YP_904278.1	membrane protein
YP_904279.1	membrane protein; thought to be involved in active transport of osmoprotectant (glycine betaine/carnitine/choline/L- proline) across the membrane (import) responsible for energy coupling to the transport system.
YP_904280.1	membrane protein; maybe involved in active transport of osmoprotectant (glycine betaine/carnitine/choline/L- proline) across the membrane (import) responsible for the translocation of the substrate across the membrane.
YP_904281.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein
YP_904283.1	membrane protein; thought to be involved in transport of ammonium across the membrane (export) responsible for the translocation of the substrate across the membrane.
YP_904284.1	cytoplasmic protein
YP_904285.1	N-term truncated by frame-shift mutation; cytoplasmic protein
YP_904286.1	cytoplasmic protein; involved in transcriptional mechanism.
YP_904287.1	cytoplasmic protein; maybe involved in transcriptional mechanism.
YP_904288.1	secreted protein; function unknown. the P60 protein is a major extracellular protein may be involved in the invasion of host cells.
YP_904289.1	cytoplasmic protein
YP_904290.1	cytoplasmic protein
YP_904291.1	cytoplasmic protein
YP_904292.1	cytoplasmic protein
YP_904294.1	cytoplasmic protein
YP_904295.1	secreted protein
YP_904296.1	cytoplasmic protein
YP_904297.1	membrane protein
YP_904298.1	cytoplasmic protein
YP_904299.1	membrane protein
YP_904300.1	membrane protein
YP_904301.1	secreted protein
YP_904302.1	leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase
YP_904303.1	membrane protein; function unknown, possibly involved in cellular metabolism.
YP_904304.1	Detected in the membrane fraction by proteomics (LC- MS/MS); cytoplasmic protein; possibly involved in transcriptional mechanism.
YP_904305.1	cytoplasmic protein; involved in transcriptional mechanism.
YP_904306.1	cytoplasmic protein; function unknown, probably involved in cellular metabolism.
YP_904307.1	cytoplasmic protein; function unknown, probably involved in lipid biosynthesis.
YP_904308.1	involved in phosphatidylinositol (pi) biosynthetic pathway [catalytic activity: d-glucose 6-phosphate = 1L- myo-inositol 1-phosphate]
YP_904309.1	cytoplasmic protein
YP_904310.1	membrane protein
YP_904311.1	cytoplasmic protein
YP_904312.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; involved in peptidoglycan synthesis (at the final stages), cell wall formation. synthesis of cross-linked peptidoglycan from the lipid intermediates. the enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits)
YP_904313.1	membrane protein
YP_904314.1	cytoplasmic protein
YP_904315.1	binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21
YP_904316.1	binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA
YP_904317.1	binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit
YP_904318.1	in Escherichia coli this protein is wrapped around the base of the L1 stalk
YP_904319.1	cytoplasmic protein; participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. the intein is an endonuclease (potential)
YP_904320.1	cytoplasmic protein
YP_904321.1	cytoplasmic protein; function unknown, possibly involved in cellular metabolism.
YP_904322.1	cytoplasmic protein
YP_904323.1	cytoplasmic protein
YP_904324.1	cytoplasmic protein
YP_904325.1	cytoplasmic protein; involved in transcriptional mechanism.
YP_904326.1	cytoplasmic protein
YP_904327.1	cytoplasmic protein
YP_904328.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; may form an ATP-driven O-antigen/lipopolysaccharide export apparatus, in association with RfbE. responsible for the translocation of the substrate across the membrane.
YP_904329.1	membrane protein; possibly involved in rhamnose biosynthesis
YP_904330.1	membrane protein; may form an ATP-driven O-antigen/lipopolysaccharide export apparatus, in association with RfbD. responsible for energy coupling to the transport system.
YP_904331.1	cytoplasmic protein
YP_904332.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_904333.1	membrane protein; function unknown, probably involved in cellular metabolism.
YP_904334.1	membrane protein; function unknown, probably involved in cellular metabolism.
YP_904335.1	PPE62; membrane protein
YP_904336.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_904337.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_904338.1	catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate
YP_904339.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_904340.1	cytoplasmic protein
YP_904341.1	catalyzes the formation of acetaldehyde from ethanolamine
YP_904342.1	membrane protein
YP_904343.1	Also detected in the cytoplasmic fraction by 2D-LC- MS/MS.; membrane protein; function unknown, probably involved in cellular metabolism.
YP_904344.1	membrane protein; function unknown, probably involved in cellular metabolism.
YP_904345.1	cytoplasmic protein
YP_904346.1	membrane protein
YP_904347.1	cytoplasmic protein; function unknown, probably involved in cellular metabolism [catalytic activity: CO + H(2)O + acceptor = CO(2) + reduced acceptor]
YP_904348.1	cytoplasmic protein; probably involved in cellular metabolism [catalytic activity: CO + H(2)O + acceptor = CO(2) + reduced acceptor]
YP_904349.1	cytoplasmic protein; possibly involved in transcriptional mechanism.
YP_904350.1	secreted protein; thought to be involved in protein transport (export)
YP_904351.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; possibly causes methylation of RNA.
YP_904352.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_904353.1	involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate
YP_904354.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; function unknown, but possibly involvement in lipid metabolism.
YP_904355.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_904356.1	cytoplasmic protein; oxidizes fatty acids using specific components (by similarity) [catalytic activity: (3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H(2)O]
YP_904357.1	Detected in the cytoplasmic fraction by LCMSMS. Also detected in the extracellular matrix and the membrane fraction by proteomics.; membrane protein; ATPase subunit of an intracellular ATP-dependent protease. in M. tuberculosis H37Rv it is regulated positively by SigH and negatively by HspR.
YP_904358.1	cytoplasmic protein; function unknown, probably involved in cellular metabolism.
YP_904359.1	cytoplasmic protein; possible carbohydrate transport and metabolism
YP_904360.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_904361.1	cytoplasmic protein; required for the transposition of the insertion element IS2606.
YP_904362.1	cytoplasmic protein; required for the transposition of insertion element IS2404. ORF is extended by 50 aa.
YP_904363.1	cytoplasmic protein
YP_904364.1	cytoplasmic protein; involved in transcriptional mechanism.
YP_904365.1	membrane protein; function unknown, possibly involved in cellular metabolism.
YP_904366.1	membrane protein; function unknown, contains NADH-flavin reductase domain
YP_904367.1	catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine
YP_904368.1	membrane protein
YP_904369.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_904370.1	catalyzes the formation of phosphoenolpyruvate from pyruvate
YP_904371.1	cytoplasmic protein
YP_904372.1	cytoplasmic protein; thought to be involved in detoxification reactions following oxidative damage to lipids [catalytic activity: an epoxide + H(2)O = a glycol]
YP_904373.1	cytoplasmic protein; involved in transcriptional mechanism.
YP_904374.1	cytoplasmic protein
YP_904375.1	cytoplasmic protein; supposed involved in detoxification reactions.
YP_904376.2	similar to full-length Gnd, these proteins seems to have a truncated C-terminal 6PGD domainin; in Methylobacillus flagellatus this gene is essential for NAD+-dependent oxidation of 6-phosphogluconate
YP_904377.1	catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate
YP_904378.1	cytoplasmic protein
YP_904379.1	cytoplasmic protein
YP_904380.1	cytoplasmic protein
YP_904381.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.
YP_904382.1	cytoplasmic protein
YP_904383.1	cytoplasmic protein; function unknown, probably involved in cellular metabolism.
YP_904384.1	cytoplasmic protein
YP_904385.1	membrane protein
YP_904387.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_904388.1	cytoplasmic protein
YP_904389.1	cytoplasmic protein; required for the transposition of the insertion element IS2606.
YP_904390.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_904391.1	translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1
YP_904392.1	membrane protein
YP_904393.1	catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway
YP_904394.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.
YP_904395.1	bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides
YP_904396.1	catalyzes the bidirectional exonucleolytic cleavage of DNA
YP_904397.1	cytoplasmic protein; function unknown, probably involved in cellular metabolism
YP_904398.1	cytoplasmic protein
YP_904399.1	cytoplasmic protein
YP_904400.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_904401.1	membrane protein
YP_904402.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein
YP_904403.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_904404.1	type II fructose 1,6-bisphosphatae; in Escherichia coli this protein forms a dimer and binds manganese
YP_904405.1	class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle
YP_904406.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_904407.1	membrane protein; probably involved in carbohydrate degradation. may hydrolyse the glycosidic bond between two or more carbohydrates or between a carbohydrate and a non- carbohydrate moiety.
YP_904409.1	Also detected in the membrane fraction by proteomics (2D-LC-MS/MS); cytoplasmic protein; thought to catalyze the principal conversion of saturated fatty acids to unsaturated fatty acids. thought to convert stearoyl-ACP to oleoyl-ACP by introduction of a cis double bond between carbons delta-9 and delta-10 of the acyl chain [catalytic activity: stearoyl-[acyl-carrier protein] + AH2 + O2 = oleoyl-[acyl-carrier protein] + a + 2 H2O]
YP_904410.1	catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate
YP_904411.1	catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis
YP_904412.1	PE_PGRS20; membrane protein
YP_904413.1	membrane protein
YP_904414.1	membrane protein
YP_904415.1	cytoplasmic protein; catalyzes the first committed step in the synthesis of decaprenyl diphosphate, a molecule which has a central role in the biosynthesis of most features of the mycobacterial cell wall. adds one isoprene unit to omega,E- geranyl diphosphate. in mycobacterium
YP_904416.1	potential role involved in virulence; membrane protein
YP_904417.1	cytoplasmic protein
YP_904418.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; membrane protein
YP_904419.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_904420.1	cytoplasmic protein; mycothiol-dependent detoxification enzyme, involved in mycothiol biosynthesis.
YP_904421.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_904422.1	necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
YP_904423.1	catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine
YP_904424.1	Detected in the membrane fraction by proteomics (2D- LC-MS/MS); membrane protein
YP_904425.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS. Also detected in the membrane fraction by proteomics (LC-MS/MS); cytoplasmic protein; thought to be involved in homocysteine transulfuration [catalytic activity: L-serine + L- homocysteine = cystathionine + H2O]
YP_904426.1	Detected in the cytoplasmic fraction by proteomics.; cytoplasmic protein; hydrolyses lipids
YP_904427.1	secreted protein
YP_904428.1	Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation
YP_904429.1	membrane protein
YP_904430.1	catalyzes the formation of 3-hydroxy-2-methylpropanoate from 3-hydroxy-2-methylpropanoyl-CoA
YP_904431.1	Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA
YP_904432.1	membrane protein
YP_904433.1	PE_PGRS9_3; membrane protein
YP_904434.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_904435.1	cytoplasmic protein
YP_904436.1	cytoplasmic protein
YP_904437.1	membrane protein
YP_904438.1	cytoplasmic protein
YP_904439.1	cytoplasmic protein
YP_904440.1	membrane protein
YP_904441.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_904442.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_904443.1	Detected in the membrane fraction by 2D-LC-MS/MS.; cytoplasmic protein
YP_904444.1	cytoplasmic protein
YP_904445.1	cytoplasmic protein; thought to play an important role in the mineralization of sulfates [catalytic activity: a phenol sulfate + H2O = a phenol + sulfate]
YP_904446.1	activates fatty acids by binding to coenzyme A
YP_904448.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_904449.1	membrane protein; metal cation-transporting ATPase; possibly catalyzes the transport of undeterminated metal cation with hydrolyse of ATP [catalytic activity: ATP + H(2)O + undeterminated metal cation(in) = ADP + phosphate + undeterminated metal cation(out)]
YP_904450.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_904451.1	Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA
YP_904452.1	membrane protein; this protein is a component of the acetyl coenzyme a carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [catalytic activity ATP + acetyl-CoA + HCO(3)(- ) = ADP + phosphate + malonyl-CoA]
YP_904453.1	C-term truncated 20aa.; membrane protein; function unknown, but maybe involved in efflux system (probably sugar or drug transport)
YP_904454.1	cytoplasmic protein; could be involved in biotin biosynthesis (at the first step) [catalytic activity: 6-carboxyhexanoyl-CoA + L- alanine = 8-amino-7-oxononanoate + CoA + CO2]
YP_904455.1	cytoplasmic protein; involved in cysteine biosynthesis [catalytic activity : O3-acetyl-L-serine + H(2)S = L-cysteine + acetate]
YP_904456.1	cytoplasmic protein; involved in transcriptional mechanism
YP_904457.1	cytoplasmic protein
YP_904458.1	Also detected in the membrane fraction by proteomics (2D-LC-MS/MS); membrane protein; transcriptional regulator part of the two component regulatory system PrrA/PrrB. thought to be involved in the environmental adaptation , specifically in an early phase of the intracellular growth.
YP_904459.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; sensor part of the two component regulatory system PrrA/PrrB. thought to be involved in the environmental adaptation , specifically in an early phase of the intracellular growth.
YP_904460.1	membrane protein
YP_904461.1	membrane protein; the protein behaved as a porin of low specific activity. structural protein that may protect the integrity of the bacterium.
YP_904462.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein
YP_904463.1	cytoplasmic protein; function unknown, probably involved in cellular metabolism.
YP_904464.1	type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH
YP_904465.1	Also detected in the cytoplamic fraction by LCMSMS; membrane protein; function unknown, probably involved in cellular metabolism.
YP_904466.1	cytoplasmic protein; involved in biosynthesis of pyridoxine (vitamin B6) and pyridoxal phosphate. oxidize Pnp and PMP into pyridoxal 5'-phosphate (PLP)[catalytic activity: pyridoxamine 5'-phosphate + H(2)O + O(2) = pyridoxal 5'- phosphate + NH(3) + H(2)O(2)]
YP_904467.1	forms citrate from oxaloacetate and acetyl-CoA; functions in TCA cycle
YP_904468.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_904469.1	Detected in the cytoplasmic and secreted fractions by 2D-LC-MS/MS.; cytoplasmic protein
YP_904470.1	cytoplasmic protein; serves as the first electron transfer protein in all the P450 systems [catalytic activity: reduced adrenodoxin + NADP+ = oxidized adrenodoxin + NADPH]
YP_904471.1	cytoplasmic protein
YP_904472.1	catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate
YP_904473.1	cytoplasmic protein
YP_904474.1	membrane protein
YP_904475.1	cytoplasmic protein; causes methylation.
YP_904476.1	cytoplasmic protein; thought to be involved in transcriptional mechanism.
YP_904477.1	membrane protein
YP_904478.1	Detected in the membrane fraction by proteomics (LC- MS/MS); cytoplasmic protein
YP_904479.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; membrane protein
YP_904480.1	membrane protein
YP_904481.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_904482.1	cytoplasmic protein
YP_904483.1	cytoplasmic protein
YP_904484.1	cytoplasmic protein; function unknown, but involved in lipid degradation.
YP_904485.1	cytoplasmic protein; function unknown, thought to act in response to low temperature.
YP_904486.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_904487.1	together with moaC, is involved in the conversion of a guanosine derivative (GXP) into molybdopterin precursor Z
YP_904488.1	cytoplasmic protein; involved in molybdenum cofactor biosynthesis.
YP_904489.1	membrane protein; function unknown. may be promote the resuscitation and growth of dormant, nongrowing cell.
YP_904490.1	cytoplasmic protein; possibly a molybdenum biosynthesis cofactor. conversion of molybdopterin precursor Z into molybdopterin requires transfer of two sulfur atoms to precursor Z (to generate the dithiolene group) this is catalyzed by the converting factor composed of a small and large subunit.
YP_904491.1	cytoplasmic protein; involved in molybdopterin biosynthesis; involved in the biosynthesis of a demolybdo-cofactor (molybdopterin), necessary for molybdo-enzymes.
YP_904492.1	cytoplasmic protein; involved in the biosynthesis of molybdopterin.
YP_904495.1	cytoplasmic protein; involved in nucleotide excision repair. has helicase activity: acts by opening DNA either around the RNA transcription start site or the DNA damage.
YP_904496.1	cytoplasmic protein
YP_904497.1	membrane protein
YP_904498.1	Detected in the membrane fraction by proteomics (2D- LC-MS/MS); membrane protein; function unknown, may have reductase activity
YP_904499.1	cytoplasmic protein
YP_904500.1	Also detected in the cytoplasmic fraction.; membrane protein
YP_904501.1	Detected in the membrane fraction by proteomics (LC- MS/MS) Also detected in the extracellular matrix by proteomics.; membrane protein; involved in fatty acid degradation (probably in fatty acid beta-oxidation cycle)
YP_904502.1	Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation
YP_904503.1	cytoplasmic protein; function unknown, probably involved in cellular metabolism.
YP_904504.1	cytoplasmic protein
YP_904505.1	cytoplasmic protein; conserved hypothetical protein
YP_904506.1	Detected in the membrane fraction by proteomics (2D- LC-MS/MS); membrane protein; possible indole-3-pyruvate decarboxylase; [catalytic activity: 3-(indol-3-YL) pyruvate = 2-(indol-3- YL)acetaldehyde + CO2], or possible pyruvate decarboxylase; [catalytic activity: a 2-oxo acid = an aldehyde + CO2]
YP_904507.1	cytoplasmic protein; conserved hypothetical protein
YP_904508.1	membrane protein
YP_904509.1	membrane protein
YP_904510.1	cytoplasmic protein; function unknown, contains a hydrolytic domain.
YP_904511.1	membrane protein
YP_904512.1	cytoplasmic protein; oxidizes fatty acids using specific components (by similarity) [catalytic activity: (3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H(2)O]
YP_904513.1	secreted protein
YP_904514.1	cytoplasmic protein
YP_904515.1	cytoplasmic protein; cytochromes P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
YP_904516.1	membrane protein; involved in the fatty acid biosynthesis [catalytic activity: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH]
YP_904517.1	cytoplasmic protein; ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.
YP_904518.1	cytoplasmic protein; cytochromes P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
YP_904519.1	cytoplasmic protein; function unknown, but supposed involvement in lipid degradation.
YP_904520.1	cytoplasmic protein
YP_904521.1	membrane protein; function unknown, possibly involved in transport of sulfate across the membrane.
YP_904522.1	cytoplasmic protein; function unknown, but supposed involvement in lipid degradation.
YP_904523.1	cytoplasmic protein; could be involved in transcriptional mechanism.
YP_904524.1	cytoplasmic protein; cytochromes P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
YP_904525.1	cytoplasmic protein; function unknown, possibly involved in cellular metabolism.
YP_904526.1	cytoplasmic protein; function unknown, probably involved in cellular metabolism.
YP_904527.1	cytoplasmic protein
YP_904528.1	membrane protein; function unknown, hydrolyses peptides.
YP_904529.1	cytoplasmic protein; hydrolysis of peptide bonds
YP_904530.1	cytoplasmic protein; cytochromes P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
YP_904531.1	cytoplasmic protein; ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.
YP_904532.1	cytoplasmic protein; function unknown, maybe a transcriptional regulator
YP_904533.1	cytoplasmic protein
YP_904534.1	membrane protein; thought to be involved in transport of undeterminated substrate (possibly drug) across the membrane. responsible for the translocation of the substrate across the membrane.
YP_904535.1	membrane protein
YP_904536.1	Also detected in the cytoplasmic and the membrane fraction by proteomics..; membrane protein; probable oxidase, showing similarity with several oxidases, mainly L-ascorbate oxidases and copper resistance proteins
YP_904537.1	Transmembrane helix. Detected in the membrane and the extracellular fractions by proteomics; membrane protein; function unknown, predicted hydrolase or acyltransferase domain.
YP_904538.1	Detected in the membrane fraction by proteomics (2D- LC-MS/MS) Also detected in the cytoplamic fraction by LC- MS/MS; cytoplasmic protein; putative cyclase
YP_904539.1	catalyzes the formation of 5-alpha-androstane-3,17-dione from androsterone; Acts on other 3-alpha-hydroxysteroids and on 9-, 11- and 15-hydroxyprostaglandin.
YP_904540.1	cytoplasmic protein
YP_904541.1	initiates steroid ring degradation; catalyzes the transhydrogenation of 3-keto-4-ene-steroid to 3-keto-1,4-diene-steroid e.g., progesterone to 1,4-androstadiene-3,17-dione
YP_904542.1	catalyzes the cleavage of 3-(2,3-dihydroxyphenyl) propionate into 2-hydroxy-6-oxonona-2,4-diene-1,9-dioate; part of the 3-phenylpropionic acid degradation pathway; member of the protocatechuate 4,5-dioxygenase family
YP_904543.1	cytoplasmic protein; involved in transcriptional mechanism.
YP_904544.1	membrane protein
YP_904545.1	membrane protein; possible sensor part of a two component regulatory system
YP_904546.1	cytoplasmic protein
YP_904547.1	membrane protein
YP_904548.1	membrane protein
YP_904549.1	membrane protein; transport system kinase - possibly arginine
YP_904550.1	cytoplasmic protein; function unknown but may be involved in fatty acid oxidation (BetA oxidation)
YP_904551.1	cytoplasmic protein; specifically catalyzes the removal of N-terminal proline residues from peptides. thought to release the N- terminal proline from the dipeptides, pro-pro, pro-gln, pro-trp and pro-tyr; also from amides (pro-beta na) and oligopeptides, pro-leu-glynH2, pro-leu-gly and pro-phe-gly- lys. higher activity toward small peptides (up to three residues), but very low activity for longer peptides [catalytic activity: release of a N-terminal proline from a peptide]
YP_904552.1	cytoplasmic protein; lipid metabolism
YP_904553.1	cytoplasmic protein; involved in lipid metabolism.
YP_904554.1	cytoplasmic protein; involved in lipid metabolism.
YP_904555.1	cytoplasmic protein
YP_904556.1	cytoplasmic protein; similar to ferredoxin reductase electron transfer proteins
YP_904557.1	cytoplasmic protein
YP_904558.1	cytoplasmic protein
YP_904559.1	cytoplasmic protein; involved in propionic acid fermentation. catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid- cycle intermediates [catalytic activity : (R)-2-methyl-3- oxopropanoyl-CoA = succinyl- CoA]
YP_904560.1	cytoplasmic protein; catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates [catalytic activity : (R)-2-methyl-3-oxopropanoyl-CoA = succinyl- CoA] the enzyme methylmalonyl-CoA mutase is a member of a class of enzymes that uses coenzyme B12 (adenosylcobalamin) as a cofactor. the enzyme induces the formation of an adenosyl radical from the cofactor. this radical then initiates a free-radical rearrangement of its substrate, succinyl-CoA, to methylmalonyl-CoA.
YP_904561.1	cytoplasmic protein; possible methylase
YP_904562.1	membrane protein
YP_904563.1	cytoplasmic protein; transposase for IS2404
YP_904564.1	secreted protein; function unknown, contains a N-term cellobiohydrolase a (1,4-beta-cellobiosidase a) domain and a C-term cellulose-binding domain (CBD) domain. the CBD is found either at the N-term or at the C-terminal extremity of endoglucanases, cellobiohydrolases (exoglucanases), or xylanases
YP_904565.1	membrane protein
YP_904566.1	cytoplasmic protein; converts farensyl pyrophosphate to geranylgeranyl pyrophosphate, the latter being the substrate for CrtB in the production of phytoene during carotenoid synthesis
YP_904567.1	cytoplasmic protein; part of carotenoid biosynthesis cluster - photochromogenesis
YP_904568.1	membrane protein; involved in carotenoid biosynthesis
YP_904569.1	cytoplasmic protein; involved in carotenoid biosynthesis
YP_904570.1	cytoplasmic protein; involved in transcriptional mechanism.
YP_904571.1	catalyzes the isomerization of isopentenyl pyrophosphate to dimethylallyl diphosphate
YP_904572.1	cytoplasmic protein
YP_904573.1	membrane protein
YP_904574.1	membrane protein; involved in L-asparagine transport
YP_904575.1	membrane protein
YP_904576.1	membrane protein; function unknown, predicted ATPase domain
YP_904577.1	cytoplasmic protein; transposase for IS2404
YP_904578.1	cytoplasmic protein; contains amidohydrolase domain
YP_904579.1	membrane protein
YP_904580.1	Detected in the secreted fraction by 2D-LC-MS/MS.; secreted protein; possibly involved in cold acclimatization processes (the production of the protein is supposed predominantly induced at low temperatures)
YP_904581.1	cytoplasmic protein; function unknown, possibly involved in ATP- dependent RNA unwinding, enzymes of this class are needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation.
YP_904582.1	cytoplasmic protein
YP_904583.1	one of two methionine synthases in Escherichia coli; MetH catalyzes a methyl transfer reaction from methyltetrahydrofolate to homocysteine to create methionine; requires zinc for activity
YP_904584.1	cytoplasmic protein; contains a nucleotidyltransferase domain
YP_904585.1	cytoplasmic protein
YP_904586.1	cytoplasmic protein; transposase for IS2404
YP_904587.1	membrane protein
YP_904588.1	With PurL and PurQ catalyzes the conversion of formylglycinamide ribonucleotide, ATP, and glutamine to formylglycinamidine ribonucleotide, ADP, and glutamate in the fourth step of the purine biosynthetic pathway
YP_904589.1	catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis
YP_904590.1	cytoplasmic protein
YP_904591.1	cytoplasmic protein; contains mannose-6-phosphate isomerase [carbohydrate transport and metabolism]
YP_904592.1	cytoplasmic protein; contains pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component domain
YP_904593.1	Also detected in the extracellular matrix and membrane fraction by proteomics.; secreted protein; function unknown, high domain homology to Linocin_M18, Linocin_M18 bacteriocin protein.  the Linocin_M18 region is found mostly in eubacteria, though homologous sequences have been identified in archaea
YP_904594.1	membrane protein; contains Dyp-type peroxidase domain. this family of dye-decolourising peroxidases lack a typical heme-binding region
YP_904595.1	cytoplasmic protein; domain similarity with acetyltransferases
YP_904596.1	catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis
YP_904597.1	secreted protein; contains CAAX amino terminal protease domain. members of this family are probably proteases; the family contains CAAX prenyl protease. the proteins contain a highly conserved Glu-Glu motif at the amino End of the alignment. the alignment also contains two histidine residues that may be involved in zinc binding
YP_904598.1	cytoplasmic protein; contains phosphohydrolase domain
YP_904599.1	cytoplasmic protein; thought to be involved in exopolysaccharide and/or lipopolysaccharide biosynthetic pathway [catalytic activity: UDP-glucose = UDP-galactose]
YP_904600.1	membrane protein
YP_904601.1	cytoplasmic protein
YP_904602.1	Catalyzes first step of the de novo purine nucleotide biosynthetic pathway
YP_904603.1	catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis
YP_904604.1	cytoplasmic protein
YP_904605.1	cytoplasmic protein; contains predicted aminomethyltransferase domain, related to GcvT - involved in the catabolism of glycine
YP_904606.1	membrane protein; metal cation-transporting ATPase; possibly catalyzes the transport of undetermined metal cation with hydrolyse of ATP [catalytic activity: ATP + H(2)O + undetermined metal cation(in) = ADP + phosphate + undetermined metal cation (out)]
YP_904607.1	cytoplasmic protein
YP_904608.1	cytoplasmic protein
YP_904609.1	catalyzes the formation of 4-aminobenzoate and pyruvate from 4-amino-4-deoxychorismate
YP_904610.1	cytoplasmic protein; N-terminal truncated in relation to orthologs
YP_904611.1	membrane protein; no H37Rv ortholog - very small, doubtful ORF
YP_904612.1	cytoplasmic protein
YP_904613.1	Also detected in the membrane fraction by proteomics.; cytoplasmic protein; may be a sulfotransferase involved in the formation of thiosulfate [catalytic activity: thiosulfate + cyanide = sulfite + thiocyanate]
YP_904614.1	membrane protein
YP_904615.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_904616.1	cytoplasmic protein; involved in transcriptional mechanism.
YP_904617.1	cytoplasmic protein; involved in the fourth step of mycothiol biosynthesis
YP_904618.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; involved in phosphate transport
YP_904619.1	membrane protein; nvolved in active transport of inorganic phosphate across the membrane (import); responsible for the translocation of the substrate across the membrane. this is one of the proteins required for binding-protein- mediated phosphate transport.
YP_904620.1	ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation
YP_904621.1	Detected in the membrane fraction by proteomics (2D- LC-MS/MS); cytoplasmic protein; involved in transcriptional regulation of active transport of inorganic phosphate across the membrane
YP_904622.1	cytoplasmic protein; domain homology - tRNA-dihydrouridine synthase [translation, ribosomal structure and biogenesis]
YP_904623.1	cytoplasmic protein; involved in mycolic acid biosynthesis
YP_904624.1	membrane protein
YP_904625.1	cytoplasmic protein
YP_904626.1	cytoplasmic protein
YP_904627.1	cytoplasmic protein; function unknown, domain homology to CumB, cytosine/adenosine deaminases.
YP_904628.1	membrane protein; function unknown, may be involved in polyketide biosynthesis [secondary metabolites biosynthesis, transport, and catabolism]
YP_904629.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_904630.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; domain: regulator of polyketide synthase expression
YP_904631.1	membrane protein; thought to play an important role in the mineralization of sulfates [catalytic activity: a phenol sulfate + H2O = a phenol + sulfate]
YP_904632.1	cytoplasmic protein
YP_904633.1	cytoplasmic protein; domain homology: transthyretin, transthyretin precursor (formerly prealbumin) transthyretin is a thyroid hormone-binding protein that transports thyroxine from the bloodstream to the brain. mutations in the human transthyretin are associated with several genetic disorders
YP_904634.1	membrane protein; domain: xanthine dehydrogenase, iron-sulfur cluster and FAD-binding subunit A [nucleotide transport and metabolism]
YP_904635.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein
YP_904636.1	cytoplasmic protein; function unknown, contains a UbiH domain, 2- polyprenyl-6-methoxyphenol hydroxylase and related FAD- dependent oxidoreductases [coenzyme metabolism / energy production and conversion]
YP_904637.1	Detected in the membrane fraction by proteomics.; membrane protein
YP_904638.1	Detected in the membrane fraction by proteomics; membrane protein; involved in transcriptional mechanism. part of the two component regulatory system PhoP/PhoQ. this protein is thought to be a positive regulator for the phosphate regulon, required for intracellular growth. transcription of this operon is positively regulated by PhoB and PhoR when phosphate is limited
YP_904639.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; sensor part of a two component regulatory system. this protein is thought to be a sensor kinase for the phosphate regulon. transcription of this operon is positively regulated by PhoB and PhoR when phosphate is limited
YP_904640.1	Detected in the extracellular matrix by proteomics. Also detected in the cytoplasmic fraction by 2D-LC-MS/MS.; cytoplasmic protein; Hit family protein: diadenosine tetraphosphate (Ap4A) hydrolase and other Hit family hydrolases [nucleotide transport and metabolism / carbohydrate transport and metabolism / general function prediction only]
YP_904641.1	secreted protein
YP_904642.1	cytoplasmic protein; contains nuclear transport factor 2 (NTF2) domain
YP_904643.1	cytoplasmic protein; function unknown, domain homology suggests possible NADH:flavin oxidoreductase
YP_904644.1	membrane protein; thought to catalyze the reversible oxidation of ethanol to acetaldehyde with the concomitant reduction of NAD. probably acts on primary or secondary alcohols or hemiacetals [catalytic activity: an alcohol + NAD+ = an aldehyde or ketone + NADH]
YP_904645.1	cytoplasmic protein
YP_904646.1	cytoplasmic protein; ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. probably involved in electron transport for cytochrome P- 450 system.
YP_904647.1	cytoplasmic protein; involved in sterol biosynthesis. its biological substrate is not known. catalyzes C14-demethylation of lanosterol, 24,25-dihydrolanosterol and obtusifoliol which is critical for ergosterol biosynthesis. it transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3- beta-ol.
YP_904648.1	membrane protein; function unknown, domain homology to short-chain dehydrogenase/reductase family
YP_904649.1	cytoplasmic protein; cytochrome P450s are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics
YP_904650.1	membrane protein
YP_904651.1	cytoplasmic protein; oxidizes a variety of aldehydes [catalytic activity: an aldehyde + NAD+ + H2O = an acid + NADH]
YP_904652.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; membrane protein
YP_904653.1	cytoplasmic protein; involved in aromatic hydrocarbons catabolism. thought to be involved in the catabolism of protocatechuate to succinate-and acetyl-CoA in the beta- ketoadipate pathway (at the third step) [catalytic activity: 2-carboxy-5-oxo-2,5-dihydrofuran-2-acetate = 5- oxo-4,5-dihydrofuran-2-acetate + CO(2)]
YP_904654.1	catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis
YP_904655.1	membrane protein; involved in signal transduction (via phosphorylation) [catalytic activity: ATP + a protein = ADP + a phosphoprotein]
YP_904656.1	cytoplasmic protein; domain: UspA, universal stress protein UspA and related nucleotide-binding proteins [signal transduction mechanisms]
YP_904657.1	membrane protein; involved in biosynthesis of a demolybdo cofactor (molybdopterin), necessary for molybdoenzymes. plays a role in the activation of the small subunit of the molybdopterin converting factor (MoaD)
YP_904658.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_904659.1	cytoplasmic protein; besides the cephalosporin acylase I activity which converts GL-7ACA into 7-Aca; this enzyme displays some gamma glutamyltranspeptidase activity: Ggt plays a key role in the gamma-glutamyl cycle, a pathway for the synthesis and degradation of glutathione. [catalytic activity 1: 7-beta-(4-carboxybutanamido)-cephalosporanic acid + H2O = 7-aminocephalosporanic acid + glutaric acid] [catalytic activity 2: (5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl-amino acid]
YP_904660.1	membrane protein; function unknown, contains esterase domain
YP_904661.1	membrane protein; contains transcriptional regulatory domain
YP_904662.1	cytoplasmic protein
YP_904663.1	Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide
YP_904664.1	cytoplasmic protein; cytochromes P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
YP_904665.1	membrane protein
YP_904666.1	cytoplasmic protein; possibly involed in transcription regulation; DNA- binding.
YP_904667.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS. Also detected in the membrane fraction by proteomics (LC-MS/MS); cytoplasmic protein; interconversion aldehyde and acid [catalytic activity: an aldehyde + NAD+ + H2O = an acid + NADH]
YP_904668.1	cytoplasmic protein
YP_904669.1	membrane protein
YP_904670.1	catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase
YP_904671.1	cytoplasmic protein; cleaves peptide bonds on the C-terminal side of LysYL and argininyl residues [catalytic activity: hydrolysis of arg-|-xaa and lys-|-xaa bonds in oligopeptides, even when P1' residue is proline]
YP_904672.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_904673.1	cytoplasmic protein; TetR-family
YP_904674.1	membrane protein; translocase that confers resistance to substances of high hydrophobicity. involved in transport of multidrug across the membrane (export): multidrug resistance by an export mechanism. responsible for the translocation of the substrate across the membrane.
YP_904675.1	cytoplasmic protein
YP_904676.1	membrane protein
YP_904678.1	secreted protein
YP_904679.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_904680.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_904681.1	cytoplasmic protein
YP_904682.1	cytoplasmic protein
YP_904683.1	cytoplasmic protein
YP_904684.1	cytoplasmic protein
YP_904685.1	cytoplasmic protein
YP_904686.1	cytoplasmic protein
YP_904687.1	cytoplasmic protein
YP_904688.1	cytoplasmic protein
YP_904689.1	cytoplasmic protein
YP_904690.1	membrane protein; frameshift mutant?
YP_904691.1	cytoplasmic protein; required for the transposition of the insertion element IS2606.
YP_904692.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_904693.1	cytoplasmic protein
YP_904694.1	cytoplasmic protein; may be an ADP-ribose pyrophosphatase - involved DNA replication, recombination, and repair
YP_904695.1	GntR-family transcriptional regulator; Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein
YP_904696.1	cytoplasmic protein
YP_904697.1	membrane protein; contains FtsK domain: FtsK has extensive sequence similarity to wide variety of proteins from prokaryotes and plasmids, termed the FtsK/SpoIIIE family. this domain contains a putative ATP binding P-loop motif. it is found in the FtsK cell division protein from E. coli and the stage III sporulation protein E SpoIIIE, which has roles in regulation of prespore specific gene expression in B. subtilis. a mutation in FtsK causes a temperature sensitive block in cell division and it is involved in peptidoglycan synthesis or modification. the SpoIIIE protein is implicated in intercellular chromosomal DNA transfer.
YP_904698.1	cytoplasmic protein
YP_904699.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS; cytoplasmic protein; part of a prophage not present in M. marinum
YP_904700.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_904701.1	Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA
YP_904702.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_904703.1	Detected in the membrane fraction by proteomics (2D- LC-MS/MS); membrane protein; hydrolyzes a monocarboxylic acid amide and generates a monocarboxylate [catalytic activity: a monocarboxylic acid amide + H(2)O = a monocarboxylate + NH(3)]
YP_904704.1	membrane protein; function unknown, facilitates transport of small solutes in or out of the cell.
YP_904705.1	membrane protein
YP_904706.1	cytoplasmic protein
YP_904707.1	membrane protein; domain homology to NagC, transcriptional regulator/sugar kinase [transcription / carbohydrate transport and metabolism]
YP_904708.1	membrane protein
YP_904709.1	cytoplasmic protein
YP_904710.1	cytoplasmic protein
YP_904711.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_904712.1	cytoplasmic protein
YP_904713.1	cytoplasmic protein
YP_904714.1	membrane protein; involved in transcriptional mechanism.
YP_904715.1	cytoplasmic protein
YP_904716.1	secreted protein; maybe exported
YP_904717.1	Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis
YP_904718.1	cytoplasmic protein
YP_904719.1	cytoplasmic protein
YP_904720.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein
YP_904721.1	cytoplasmic protein; dTDP-L-rhamnose biosynthesis within the O antigen biosynthesis pathway of lipopolysaccharide biosynthesis [catalytic activity: dTTP + alpha-D-glucose 1-phosphate = diphosphate + dTDP-glucose]
YP_904722.1	membrane protein; function unknown. seems to influence both cell surface interactions among mycobacteria and the interactions of the bacteria with macrophages.
YP_904723.1	membrane protein
YP_904724.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_904725.1	membrane protein; function unknown, member of the mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins
YP_904726.1	broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor
YP_904727.1	Detected in the membrane fraction by proteomics (2D- LC-MS/MS); membrane protein
YP_904728.1	cytoplasmic protein; required for the transposition of the insertion element IS2606.
YP_904729.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_904730.1	cytoplasmic protein
YP_904731.1	membrane protein; function unknown function but ortholog in M.tuberculosis induced by isoniazid and ethionamide.
YP_904732.1	membrane protein; in M. tuberculosis H37Rv this gene is induced by isoniazid (INH) or ethionamide treatment) (see Wilson et al., 1999)
YP_904733.1	membrane protein; in M. tuberculosis H37Rv IniC is an isoniazid- inducible gene
YP_904734.1	membrane protein
YP_904735.1	membrane protein
YP_904736.1	membrane protein
YP_904737.1	membrane protein
YP_904738.1	cytoplasmic protein
YP_904739.1	cytoplasmic protein
YP_904740.1	membrane protein
YP_904741.1	heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria
YP_904742.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS. Also detected in the extracellular matrix by proteomics.; cytoplasmic protein; stimulates, jointly with DnaJ, the ATPase activity of DnaK. helps to release ADP from DnaK thus allowing DnaK to recycle more efficiently. seems to be regulated negatively by HspR.
YP_904743.1	chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion
YP_904744.1	Extended C-term caused by point mutation removing stop codon. This CDS now overlap the C-term of the d/s CDS.; cytoplasmic protein; involved in transcriptional regulation (repression) of heat shock proteins e.g. DnaK, GrpE, DnaJ. binds to three inverted repeats (IR1-IR3) in the promoter region of the DnaK operon. induction: by heat shock.
YP_904745.1	cytoplasmic protein; required for the transposition of the insertion element IS2606.
YP_904746.1	cytoplasmic protein; required for the transposition of the insertion element IS2606.
YP_904747.1	cytoplasmic protein; cytochromes P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. some have been shown to bind tightly to a range of azole-based antifungal drugs (E.G. miconazole, clotrimazole)
YP_904748.1	cytoplasmic protein
YP_904749.1	membrane protein
YP_904750.1	secreted protein; function unknown, domain identity to secreted hydrolases of the SgnH_hydrolase subfamily
YP_904751.1	membrane protein
YP_904752.1	membrane protein
YP_904753.1	membrane protein; has homology to a putative esterase domain
YP_904754.1	cytoplasmic protein; some similarity to universal stress protein UspA.
YP_904755.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; metal cation-transporting ATPase; possibly catalyzes the transport of a undeterminated metal cation with the hydrolyse of ATP [catalytic activity: ATP + H(2)O + undetermined metal cation(in) = ADP + phosphate + undetermined metal cation(out)
YP_904756.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_904757.1	membrane protein; ketopantoate reductase PanE/ApbA. this is a family of 2-dehydropantoate 2-reductases also known as ketopantoate reductases. the reaction catalysed by this enzyme is: (R)-pantoate + NADP(+) <=> 2-dehydropantoate + NADPH. AbpA catalyses the NADPH reduction of ketopantoic acid to pantoic acid in the alternative pyrimidine biosynthetic (APB) pathway. ApbA and pane are allelic. ApbA, the ketopantoate reductase enzyme is required for the synthesis of thiamine via the APB biosynthetic pathway.
YP_904758.1	cytoplasmic protein
YP_904759.1	cytoplasmic protein
YP_904760.1	Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway
YP_904761.1	cytoplasmic protein; contains fructose-2,6-bisphosphatase domain [carbohydrate transport and metabolism]
YP_904762.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_904763.1	membrane protein; required during cytochrome biogenesis at the step of HemE attachment.
YP_904764.1	membrane protein; required for cytochrome C biosynthesis
YP_904765.1	membrane protein; required during cytochrome biogenesis at the step of HemE attachment.
YP_904766.1	membrane protein
YP_904767.1	membrane protein
YP_904768.1	FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs
YP_904769.1	catalyzes the formation of dimethylmenaquinone from 1,4-dihydroxy-2-naphthoate and octaprenyl diphosphate
YP_904770.1	Catalyzes the reversible phosphorolysis of 5'-deoxy-5'- methylthioadenosine (MTA) to adenine and 5-methylthio-D-ribose-1- phosphate
YP_904771.1	cytoplasmic protein; involved in galactose metabolism [catalytic activity: UDP-glucose = UDP-galactose]
YP_904772.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_904773.1	membrane protein
YP_904774.1	cytoplasmic protein; substrate (sugar) unknown [catalytic activity: NDP- sugar + dolichyl phosphate = NDP + dolichyl sugar phosphate]
YP_904775.1	cytoplasmic protein
YP_904776.1	membrane protein
YP_904777.1	cytoplasmic protein; involved in menaquinone biosynthesis. O- succinylbenzoic acid (OSB) to O-succinylbenzoyl-CoA (OSB- CoA) [catalytic activity: ATP + O-succinylbenzoate + CoA = AMP + diphosphate + O-succinylbenzoyl-CoA]
YP_904778.1	Detected in the membrane fraction by proteomics (2D- LC-MS/MS); cytoplasmic protein
YP_904779.1	membrane protein
YP_904780.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein
YP_904781.1	cytoplasmic protein
YP_904782.1	Detected in the membrane fraction by proteomics. Also detected in the cytoplasmic fraction by 2D-LC-MS/MS.; cytoplasmic protein
YP_904783.1	catalyzes the formation of 1,4-dihydroxy-2-naphthoate from O-succinylbenzoyl-CoA
YP_904784.1	cytoplasmic protein
YP_904785.1	activates fatty acids by binding to coenzyme A
YP_904786.1	membrane protein; has significant domain identity to predicted metal- dependent hydrolases
YP_904787.1	catalyzes the dehydration of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid to form O-succinylbenzoate
YP_904788.1	Detected in the membrane fraction by proteomics (2D- LC-MS/MS); membrane protein; non-haem peroxidase
YP_904789.1	SEPHCHC synthase; forms 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1- carboxylate from 2-oxoglutarate and isochorismate in menaquinone biosynthesis
YP_904790.1	membrane protein
YP_904791.1	cytoplasmic protein; involved in lipoarabinomannan (lam) biosynthesis.
YP_904792.1	cytoplasmic protein; function unknown, mar family
YP_904793.1	cytoplasmic protein
YP_904794.1	cytoplasmic protein
YP_904795.1	Catalyzes the carbon methylation reaction in the biosynthesis of ubiquinone
YP_904796.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; membrane protein
YP_904797.1	cytoplasmic protein
YP_904798.1	membrane protein; has significant domain conservation with dehydrogenases (flavoproteins) [energy production and conversion]
YP_904799.1	cytoplasmic protein; supplies polyprenyl diphosphate
YP_904800.1	putative metalloprotease
YP_904801.1	membrane protein; generates CO(2) and H(2)O from H(2)CO(3), and possibly involved in transport of sulfate across the membrane.
YP_904802.1	membrane protein; frameshift
YP_904803.1	catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate
YP_904804.1	membrane protein; hydrolyzes peptides and/or proteins. cleaves preferentially after serine residues
YP_904805.1	cytoplasmic protein; domain identity to N-acetylases of ribosomal proteins
YP_904806.1	putative nucleotide binding property based on structural studies of Haemophilus influenzae crystallized protein in PDB Accession Number 1IN0 and NMR studies of Escherichia coli YajQ; the YajQ protein from Pseudomonas synringae appears to play a role in activation of bateriophage phi6 segment L transcription
YP_904807.1	membrane protein; ABC-type transport system, involved in lipoprotein release, permease component
YP_904808.1	membrane protein
YP_904809.1	cytoplasmic protein; involved in transcriptional mechanism.
YP_904810.1	cytoplasmic protein
YP_904811.1	membrane protein; NhaP-type Na+/H+ and K+/H+ antiporter: inorganic ion transport and metabolism] antiporters are ubiquitous membrane proteins that are involved in homeostasis of H(+) and na(+) throughout the biological kingdom.
YP_904812.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_904814.1	cytoplasmic protein; involved in transcriptional mechanism.
YP_904815.1	membrane protein
YP_904816.1	cytoplasmic protein
YP_904817.1	cytoplasmic protein
YP_904818.1	cytoplasmic protein; component of the translational apparatus. furnishes a means for formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. the reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-glu-tRNA(Gln) [catalytic activity: ATP + L-glutamyl-tRNA(Gln) + L- glutamine = ADP + phosphate + L-glutaminyl-tRNA(Gln) + L- glutamate]
YP_904819.1	cytoplasmic protein
YP_904820.1	membrane protein; involved in galactose metabolism (Leloir pathway) [catalytic activity: UTP + alpha-D-galactose 1-phosphate = diphosphate + UDP-galactose]
YP_904821.1	catalyzes the formation of alpha-D-galactose 1-phosphate from D-galactose in galactose metabolism
YP_904822.1	membrane protein; ArsR family
YP_904823.1	cytoplasmic protein
YP_904824.1	membrane protein; contains hydrolase domain
YP_904825.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein
YP_904826.1	membrane protein
YP_904827.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_904829.1	Also detected in the cytoplamic fraction by LCMSMS; membrane protein
YP_904830.1	cytoplasmic protein; function unknown, imidazolonepropionase is an amidohydrolase
YP_904831.1	cytoplasmic protein
YP_904832.1	cytoplasmic protein; involved in homologous recombination
YP_904833.1	cytoplasmic protein; involved in homologous recombination.
YP_904834.1	cytoplasmic protein; involved in homologous recombination
YP_904835.1	membrane protein
YP_904836.1	catalyzes the reaction of cyanate and bicarbonate to produce ammonia and carbon dioxide
YP_904837.1	Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA
YP_904838.1	membrane protein
YP_904839.1	Detected in the cytoplasmic fraction by proteomics.; cytoplasmic protein; thought to be involved in glyoxal pathway. thioesterase that catalyses the hydrolysis of S-D-lactoyl- glutathione to form glutathione and D-lactic acid [catalytic activity: (S)-(2-hydroxyacyl)glutathione + H2O = glutathione + a 2-hydroxy acid anion]
YP_904840.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; domain homology to Arc/MetJ class transcription regulators
YP_904841.1	in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group have the CXXC motif
YP_904842.1	functions as a heterodimer along with HadB in fatty acid biosynthesis; fatty acid synthase type II; FAS-II
YP_904843.1	functions as a heterodimer along with HadA or HadC in fatty acid biosynthesis; fatty acid synthase type II; FAS-II
YP_904844.1	functions as a heterodimer along with HadB in fatty acid biosynthesis; fatty acid synthase type II; FAS-II
YP_904845.1	forms a complex with SecY and SecG; SecYEG forms a putative protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force
YP_904846.1	Modulates Rho-dependent transcription termination
YP_904847.1	binds directly to 23S ribosomal RNA
YP_904848.1	in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA
YP_904849.1	Detected in the cytoplamic fraction by LC-MS/MS. Detected in the membrane fraction by proteomics (2D-LC- MS/MS); cytoplasmic protein; methyltransferase. involved in mycolic acids modification. catalyzes unusual S-adenosyl-methionine- dependent transformation of a cis-olefin mycolic acid into a secondary alcohol. catalyzes introduction of a hydroxyl group at the distal position on mycolic acid chains to produce the hydroxyl mycolate. mycolic acids represent a major constituent of the mycobacterial cell wall complex. methyl transfer results in formation of a secondary hydroxy group with an adjacent methyl branch; olefinic mycolic acid methyl transferase.
YP_904850.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; methyltransferase involved in mycolic acid biosynthesis
YP_904851.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; methyltransferase involved in mycolic acid biosynthesis
YP_904852.1	membrane protein
YP_904853.1	cytoplasmic protein; contains a kinase domain and ATP-binding cassette
YP_904854.1	cytoplasmic protein
YP_904855.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; alpha-mannosidase activity: hydrolysis of terminal non-reducing alpha-D-mannose residues in alpha-D- mannosides.
YP_904856.1	cytoplasmic protein; nvolved in lipid metabolism; fatty acid biosynthesis [catalytic activity: malonyl-CoA + [acyl- carrier protein] = CoA + malonyl-[acyl-carrier protein]]
YP_904857.1	function unknown; probably involved in specific sugar metabolism or regulation
YP_904858.1	membrane protein
YP_904859.1	binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit
YP_904860.1	present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors
YP_904861.1	cytoplasmic protein; function unknown, involved in transcriptional mechanism
YP_904862.1	Detected in the membrane fraction by proteomics (2D- LC-MS/MS); cytoplasmic protein; dioxygenase and related enzymes [secondary metabolites biosynthesis, transport, and catabolism]
YP_904863.1	Detected in the membrane fraction by proteomics (2D- LC-MS/MS) Also detected in the cytoplasmic fraction by 2D- LC-MS/MS.; membrane protein; thought to be involved in active transport of ribonucleotide across the membrane. responsible for energy coupling to the transport system.
YP_904864.1	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme
YP_904865.1	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter
YP_904866.1	membrane protein
YP_904867.1	Assists in DNA repair by cleaving phosphodiester bonds at apurinic or apyrimidinic sties to produce new 5' ends that are base-free deoxyribose 5-phosphate residues
YP_904868.1	membrane protein
YP_904869.1	cytoplasmic protein; may be involved in lipid degradation
YP_904870.1	Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA
YP_904871.1	membrane protein; high domain identity with transcriptional repressors
YP_904872.1	Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA
YP_904873.1	Detected in the membrane fraction by proteomics (2D- LC-MS/MS); membrane protein; thought to be involved in fatty acid transport
YP_904874.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_904875.1	cytoplasmic protein
YP_904876.1	membrane protein
YP_904877.1	membrane protein
YP_904878.1	cytoplasmic protein; involved in transcriptional mechanism.
YP_904879.1	interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance
YP_904880.1	binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit
YP_904881.1	EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene
YP_904882.1	EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu
YP_904883.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_904884.1	Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis
YP_904885.1	cytoplasmic protein; ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.
YP_904886.1	cytoplasmic protein
YP_904887.1	cytoplasmic protein; involved in transcriptional mechanism.
YP_904889.1	cytoplasmic protein; required for coenzyme pyrrolo-quinoline-quinone (PQQ) biosynthesis.
YP_904890.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; involved in respiration; catalyzes conversion of lactate into pyruvate [catalytic activity: (S)-lactate + 2 ferricytochrome C = pyruvate + 2 ferrocytochrome C]
YP_904891.1	cytoplasmic protein; catalyses the hydrolysis of creatinine to creatine
YP_904892.1	membrane protein
YP_904893.1	membrane protein
YP_904894.1	cytoplasmic protein; involved in transcriptional mechanism.
YP_904895.1	cytoplasmic protein; required for the transposition of the insertion element IS2606.
YP_904896.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_904897.1	cytoplasmic protein; C-term truncated by IS2606 insertion
YP_904898.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_904899.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_904900.1	membrane protein
YP_904901.1	cytoplasmic protein
YP_904902.1	NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex
YP_904903.1	binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin
YP_904904.1	L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA
YP_904905.1	binds third domain of 23S rRNA and protein L29; part of exit tunnel
YP_904906.1	one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation
YP_904907.1	protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
YP_904908.1	binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center
YP_904909.1	forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation
YP_904910.1	located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e
YP_904911.1	one of the stabilizing components for the large ribosomal subunit
YP_904912.1	primary binding protein; helps mediate assembly; involved in translation fidelity
YP_904913.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_904914.1	membrane protein
YP_904915.1	binds to the 23S rRNA between the centers for peptidyl transferase and GTPase
YP_904916.1	assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel
YP_904917.1	part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13
YP_904918.1	located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group appear to contain the zinc-binding motif
YP_904919.1	binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
YP_904920.1	ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance
YP_904921.1	cytoplasmic protein; this is one of 3 proteins that mediate the attachment of the 5S RNA into the large ribosomal subunit.
YP_904922.1	located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance
YP_904923.1	L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7
YP_904924.1	late assembly protein
YP_904925.1	cytoplasmic protein
YP_904926.1	membrane protein; involved in digestion of the cleaved signal peptides. this activity is necessary to maintain proper secretion of mature proteins across the membrane.
YP_904927.1	cytoplasmic protein
YP_904928.1	cytoplasmic protein
YP_904929.1	cytoplasmic protein
YP_904930.1	membrane protein; function unknown, may contain two dehyrogenase domains, first showing better similarity
YP_904931.1	cytoplasmic protein
YP_904932.1	cytoplasmic protein; involved in transcriptional mechanism.
YP_904933.1	catalyzes the formation of glycerone phosphate and (S)-lactaldehyde from L-fuculose 1-phosphate
YP_904934.1	cytoplasmic protein; involved at the first committed step in the 'phosphorylated' pathway of L-serine biosynthesis. catalyzes the oxidation of D-3-phosphoglycerate to 3- phosphohydroxypyruvate [catalytic activity: 3- phosphoglycerate + NAD(+) = 3-phosphohydroxypyruvate + NADH]
YP_904935.1	membrane protein; phosphorylates D-xylulose [catalytic activity: ATP + D-xylulose = ADP + D-xylulose 5-phosphate]
YP_904936.1	Detected in the cytoplasmic and membrane fractions by LC-MS/MS. Also detected in the extracellular matrix by proteomics.; cytoplasmic protein
YP_904937.1	forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase
YP_904938.1	essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP
YP_904939.1	catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn
YP_904940.1	Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; in M. tuberculosis this protein regulates polyketide synthases and secreted or membrane proteins
YP_904941.1	membrane protein; function unknown, domain identity suggests possible role in transcription regulation
YP_904942.1	cytoplasmic protein; involved in transcriptional mechanism.
YP_904943.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein
YP_904944.1	membrane protein; catalyzes the NAD-dependent, reversible oxidation of 3-hydroxbutyrate to methylmalonate [catalytic activity: 3-hydroxy-2-methylpropanoate + NAD+ = 2-methyl-3- oxopropanoate + NADH]
YP_904945.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; lipid metabolism
YP_904946.1	Detected in the cytoplamic fraction by LCMSMS. Also detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; plays a role in valine and pyrimidine metabolism. binds fatty acyl-CoA [catalytic activity: 2-methyl-3- oxopropanoate + CoA + NAD+ = propanoyl-CoA + CO2 + NADH]
YP_904947.1	membrane protein
YP_904948.1	cytoplasmic protein; involved in dTDP-L-rhamnose biosynthesis, within the O antigen biosynthesis pathway of lipopolysaccharide biosynthesis: conversion of dTDP-4-keto-6-deoxy-D-glucose to dTDP-4-keto-rhamnose [catalytic activity: dTDP-4- dehydro-6-deoxy-D-glucose = dTDP-4-dehydro-6-deoxy-L- mannose]
YP_904949.1	cytoplasmic protein; involved in dTDP-L-rhamnose biosynthesis [catalytic activity: dTDP-glucose = DTDP-4-dehydro-6-deoxy-D-glucose + H(2)O]
YP_904950.1	cytoplasmic protein
YP_904951.1	cytoplasmic protein
YP_904952.1	stimulates the activities of the other two initiation factors, IF-2 and IF-3
YP_904953.1	smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif
YP_904954.1	located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA
YP_904955.1	located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3
YP_904956.1	primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination
YP_904957.1	catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme
YP_904958.1	is a component of the macrolide binding site in the peptidyl transferase center
YP_904959.1	mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability
YP_904960.1	membrane protein; permease that is involved in the transport across the cytoplasmic membrane of D-alanine, D-serine and glycine
YP_904961.1	membrane protein
YP_904962.1	membrane protein; hydrolysis of cutin (a polyester that forms the structure of plant cuticle)
YP_904963.1	membrane protein
YP_904964.1	membrane protein
YP_904965.1	membrane protein
YP_904966.1	membrane protein
YP_904967.1	membrane protein; function unknown but has 3 ATP binding P-loop motifs
YP_904968.1	membrane protein
YP_904969.1	secreted protein
YP_904970.1	secreted protein
YP_904971.1	in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit
YP_904972.1	forms a direct contact with the tRNA during translation
YP_904973.1	catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
YP_904974.1	cytoplasmic protein
YP_904975.1	cytoplasmic protein
YP_904976.1	Detected in the membrane fraction by proteomics (LC- MS/MS); cytoplasmic protein; hydrolase domain identity
YP_904977.1	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source
YP_904978.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_904980.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; has domain identity with YjeF-related protein N- terminus and sugar kinases c-terminus
YP_904981.1	cytoplasmic protein; catalyzes the production of GabA [catalytic activity: L-glutamate = 4-aminobutanoate + CO(2)]
YP_904982.1	converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer
YP_904983.1	secreted protein
YP_904984.1	cytoplasmic protein; ATPase domain
YP_904985.1	membrane protein; peptidase
YP_904986.1	cytoplasmic protein; this enzyme acetylates the N-terminal alanine of ribosomal protein S18 [catalytic activity: acetyl-CoA + ribosomal-protein L-alanine = CoA + ribosomal-protein N- acetyl-L-alanine]
YP_904987.1	in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity
YP_904988.1	10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring
YP_904989.1	60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is not essential for growth
YP_904990.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_904991.1	cytoplasmic protein
YP_904992.1	membrane protein
YP_904993.1	cytoplasmic protein
YP_904994.1	cytoplasmic protein
YP_904995.1	cytoplasmic protein; involved in transcriptional mechanism (growth phase- dependent)
YP_904996.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_904997.1	Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this protein is involved in expression of ribosome-associated gene products in stationary phase
YP_904998.1	cytoplasmic protein
YP_904999.1	cytoplasmic protein
YP_905000.1	catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate
YP_905001.1	catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate
YP_905002.1	membrane protein
YP_905003.1	membrane protein; involved in cholesterol metabolism [catalytic activity: cholesterol + O(2) = cholest-4-en-3-one + H(2)O(2)]
YP_905004.1	cytoplasmic protein; in E. coli this enzyme catalyses the oxygenolytic release of sulfite from taurine.
YP_905005.1	cytoplasmic protein; involved in transcriptional mechanism.
YP_905006.1	cytoplasmic protein; similar to maltose phosphorylase, a dimeric enzyme that catalyses the conversion of maltose and inorganic phosphate into beta-D-glucose-1-phosphate and glucose
YP_905007.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_905008.1	cytoplasmic protein; cellular metabolism
YP_905009.1	cytoplasmic protein
YP_905010.1	cytoplasmic protein; involved in transcriptional mechanism.
YP_905011.1	Detected in the membrane fraction by proteomics (2D- LC-MS/MS) Also detected in the cytoplasmic fraction by 2D- LC-MS/MS.; membrane protein
YP_905012.1	cytoplasmic protein; involved in transcriptional mechanism.
YP_905013.1	contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway
YP_905014.1	secreted protein
YP_905015.1	cytoplasmic protein
YP_905016.1	secreted protein; function unknown but belongs to the DNA/RNA polymerase superfamily
YP_905017.1	cytoplasmic protein; multi functional protein with fatty acyl-CoA reductase activity in C-terminal part
YP_905018.1	membrane protein
YP_905019.1	Also detected as secreted protein; cytoplasmic protein; may have dehydratase activity; contains a MaoC protein family domain
YP_905020.1	cytoplasmic protein; involved in osmoregulatory trehalose biosynthesis. mycobacteria can produce trehalose from glucose 6- phosphate and UDP-glucose (the OtsA-OtsB pathway) from glycogen-like alpha(1-->4)-linked glucose polymers (the TreY-TreZ pathway) and from maltose (the TreS pathway) [catalytic activity: trehalose 6-phosphate + H(2)O = trehalose + orthophosphate]
YP_905021.1	DNA polymerase involved in damage-induced mutagenesis and translesion synthesis. It is not the major replicative DNA polymerase.
YP_905022.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_905023.1	membrane protein
YP_905024.1	membrane protein; involved in secretion of nitrite produced by the dissimilatory reduction of nitrate. responsible for the translocation of the substrate across the membrane.
YP_905025.1	cytoplasmic protein
YP_905026.1	cytoplasmic protein
YP_905027.1	cytoplasmic protein; may be a regulatory protein
YP_905028.1	Detected in the membrane fraction by proteomics (LC- MS/MS); cytoplasmic protein; involved in the arginase pathway [catalytic activity: 1-pyrroline-5-carboxylate + NAD(+) + H(2)O = L- glutamate + NADH]
YP_905029.1	cytoplasmic protein; oxidizes proline to glutamate for use as a carbon and nitrogen source [catalytic activity: L-proline + acceptor + H2O = (S)-1-pyrroline-5-carboxylate + reduced acceptor]
YP_905030.1	cytoplasmic protein; involved in transcriptional mechanism.
YP_905031.1	membrane protein; lipid-transfer protein
YP_905032.1	cytoplasmic protein
YP_905033.1	cytoplasmic protein
YP_905034.1	cytoplasmic protein
YP_905035.1	cytoplasmic protein; oxidizes a variety of aldehydes [catalytic activity: an aldehyde + NAD+ + H2O = an acid + NADH]
YP_905036.1	cytoplasmic protein
YP_905037.1	activates fatty acids by binding to coenzyme A
YP_905038.1	cytoplasmic protein; involved in transcriptional mechanism.
YP_905039.1	PE31; membrane protein
YP_905040.1	PPE18; membrane protein
YP_905042.1	membrane protein
YP_905043.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_905044.1	membrane protein
YP_905045.1	cytoplasmic protein
YP_905046.1	Detected in the membrane fraction by proteomics.; membrane protein; function unknown, probably involved in cellular metabolism
YP_905047.1	catalyzes the formation of succinate and diaminoheptanedioate from succinyldiaminoheptanedioate
YP_905048.1	membrane protein
YP_905049.1	cytoplasmic protein
YP_905050.1	activates fatty acids by binding to coenzyme A; may be involved in acyclic terpene utilization
YP_905051.1	involved in dihydrofolate biosynthesis [catalytic activity : 2-amino-4-hydroxy-6-hydroxymethyl-7,8- dihydropteridine diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate]
YP_905052.1	cytoplasmic protein
YP_905053.1	Detected in the membrane fraction by proteomics (LC- MS/MS); secreted protein
YP_905054.1	cytoplasmic protein; involved in base excision repair. hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine from the damaged DNA polymer formed by alkylation lesions
YP_905055.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS; cytoplasmic protein
YP_905056.1	secreted protein
YP_905057.1	secreted protein
YP_905058.1	cytoplasmic protein; required for the transposition of the insertion element IS2606.
YP_905059.1	secreted protein
YP_905060.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS. Also detected in the membrane fraction by proteomics (2D-LC-MS/MS); cytoplasmic protein; function unknown, but involved in lipid degradation [catalytic activity: 2 acetyl-CoA = CoA + acetoacetyl- CoA]
YP_905061.1	cytoplasmic protein; oxidize fatty acids using specific components [catalytic activity: (3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H(2)O]
YP_905062.1	cytoplasmic protein; required for the transposition of the insertion element IS2606.
YP_905063.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_905064.1	cytoplasmic protein; required for the transposition of the insertion element IS2606.
YP_905065.1	cytoplasmic protein; function unknown, probably involved in cellular metabolism.
YP_905066.1	membrane protein
YP_905067.1	cytoplasmic protein
YP_905068.1	membrane protein
YP_905069.1	Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA
YP_905070.1	cytoplasmic protein; required for bile acid synthesis and for catabolism of branched-chain fatty acids
YP_905071.1	Detected in the cytoplasmic and membrane fraction by LC-MS/MS. Also detected in the extracellular matrix by proteomics.; cytoplasmic protein; function unknown, supposed involved in cellular metabolism.
YP_905073.1	membrane protein; thought to be involved in fatty acid transport.
YP_905074.1	cytoplasmic protein; involved in transcriptional mechanism.
YP_905075.1	cytoplasmic protein
YP_905076.1	Modulates the activities of several enzymes which are inactive in their acetylated form
YP_905077.1	cytoplasmic protein; involved in transcriptional mechanism
YP_905078.1	cytoplasmic protein
YP_905079.1	Also detected in the membrane fraction by proteomics (2D-LC-MS/MS); cytoplasmic protein
YP_905080.1	cytoplasmic protein
YP_905081.1	cytoplasmic protein
YP_905082.1	membrane protein
YP_905083.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_905084.1	membrane protein
YP_905085.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.
YP_905086.1	cytoplasmic protein
YP_905087.1	secreted protein
YP_905088.1	secreted protein
YP_905089.1	involved in the fifth mannose transfer of phosphatidylinositol mannoside synthesis
YP_905090.1	4-alpha-hydroxytetrahydrobiopterin dehydratase activity; catalyzes the formation of (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7, 8-dihydro-6H-pterin from (6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7, 8-tetrahydro-4a-hydroxypterin; functions in recycling tetrahydrobiopterin (BH4) in phenylalanine hydroxylase reaction
YP_905091.1	cytoplasmic protein; involved in the go system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8- oxoguanine) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite da and dc residues of template DNA with almost equal efficiency thus leading to AT to GC transversions. MutT specifically degrades 8-oxo-dGTP to the monophosphate.
YP_905092.1	cytoplasmic protein; function unknown, probably interacts with the ribosomes in a GTP dependent manner
YP_905093.1	membrane protein
YP_905094.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_905095.1	cytoplasmic protein; required for the transposition of the insertion element IS2606.
YP_905096.1	cytoplasmic protein; involved in mycothiol biosynthesis. 1-D-myo- inosityl-2-acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins)is converted to 1-D-myo-inosityl-2-amino-2- deoxy-alpha-D-glucopyranoside (GlcN-Ins) by this enzyme. seems to possesse weak mycothiol conjugate ami
YP_905097.1	membrane protein; function unknown -possibly a transmembrane protein
YP_905098.1	secreted protein
YP_905099.1	7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase; catalyzes radical-mediated transfer of hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO); functions in F420 biosynthesis
YP_905100.1	membrane protein
YP_905101.1	secreted protein; function unknown function (secreted protein)
YP_905102.1	cytoplasmic protein; catalyzes the NADP-dependent reduction of 2,4- dienoyl-CoA to yield trans-2- enoyl-CoA [catalytic activity: trans-2,3-didehydroacyl-CoA + NADP(+) = trans, trans-2,3,4,5-tetradehydroacyl-CoA + NADPH]
YP_905103.1	cytoplasmic protein
YP_905104.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.
YP_905105.1	catalyzes the formation of N-succinyl-LL-2,6-diaminopimelate from N-succinyl-L-2-amino-6-oxopimelate in lysine biosynthesis
YP_905106.1	cytoplasmic protein; required for the transposition of the insertion element IS2606.
YP_905107.1	PE4; membrane protein
YP_905108.1	cytoplasmic protein
YP_905109.1	cytoplasmic protein; not really known; thought to be involved in lipid biosynthesis [catalytic activity: androstan-3-alpha,17- beta-diol + NAD+ = 17-beta-hydroxyandrostan-3-one + NADH]
YP_905110.1	membrane protein; function unknown, probably involved in cellular metabolism.
YP_905111.1	cytoplasmic protein; function unknown.  contains TetR_N, bacterial regulatory proteins, TetR family domain. possibly involved in transcriptional mechanism.
YP_905112.1	cytoplasmic protein
YP_905113.1	cytoplasmic protein
YP_905114.1	cytoplasmic protein
YP_905115.1	cytoplasmic protein
YP_905116.1	cytoplasmic protein
YP_905117.1	cytoplasmic protein; cytochromes P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
YP_905118.1	cytoplasmic protein
YP_905119.1	cytoplasmic protein
YP_905120.1	membrane protein; function unknown, probably involved in cellular metabolism.
YP_905121.1	cytoplasmic protein; function unknown, lipolytic enzyme probably involved in cellular metabolism.
YP_905123.1	Also detected in the membrane fraction by proteomics (LC-MS/MS); cytoplasmic protein
YP_905124.1	cytoplasmic protein; possibly involved in transcriptional mechanism.
YP_905125.1	membrane protein
YP_905126.1	membrane protein
YP_905127.1	membrane protein; function unknown, but thought to be involved in host cell invasion (entry and survival inside macrophages)
YP_905128.1	Detected in the membrane fraction by proteomics (2D- LC-MS/MS); membrane protein; function unknown, but thought to be involved in host cell invasion.
YP_905129.1	membrane protein; function unknown, but thought to be involved in host cell invasion.
YP_905130.1	membrane protein; function unknown, but thought to be involved in host cell invasion.
YP_905131.1	Detected in the membrane fraction by proteomics (2D- LC-MS/MS); membrane protein; function unknown, but thought to be involved in host cell invasion.
YP_905132.1	Also detected in the membrane fraction by proteomics.; membrane protein; function unknown, but thought involved in host cell invasion.
YP_905133.1	Detected in the membrane fraction by proteomics (LC- MS/MS) Also detected in the cytoplasmic fraction (2D- MALDI); membrane protein
YP_905134.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_905135.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_905136.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_905137.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_905138.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.
YP_905139.1	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
YP_905140.1	cytoplasmic protein; function unknown, probably involved in cellular metabolism.
YP_905141.1	cytoplasmic protein
YP_905142.1	cytoplasmic protein; function unknown, probably involved in a cellular metabolism.
YP_905143.1	membrane protein; possibly involved in degradation [catalytic activity: hydrolysis of terminal, non-reducing beta-D- glucose residues with release of beta-D-glucose]
YP_905144.1	catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis
YP_905145.1	cytoplasmic protein
YP_905146.1	membrane protein; function unknown, possibly involved in transport of drug across the membrane.
YP_905147.1	secreted protein
YP_905148.1	cytoplasmic protein; possibly involved in transcriptional mechanism.
YP_905149.1	cytoplasmic protein; function unknown, hydrolyzes peptides and/or proteins.
YP_905150.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_905151.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_905152.1	cytoplasmic protein
YP_905153.1	membrane protein; function unknown. thought to be involved in fatty acid transport.
YP_905154.1	secreted protein
YP_905155.1	membrane protein
YP_905156.1	Detected in the membrane fraction by proteomics (LC- MS/MS) Also detected in the cytoplasmic fraction by 2D-LC- MS/MS.; membrane protein; function unknown. thought to be involved in fatty acid transport.
YP_905157.1	cytoplasmic protein
YP_905158.1	tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine
YP_905159.1	cytoplasmic protein
YP_905160.1	Also detected in the cytoplasmic fraction by 2D-LC- MS/MS.; secreted protein
YP_905161.1	catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using GTP
YP_905162.1	cytoplasmic protein; oxidizes fatty acids using specific components (by similarity) [catalytic activity: (3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H(2)O]
YP_905163.1	membrane protein
YP_905164.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_905165.1	Detected in the membrane fraction by proteomics (2D- LC-MS/MS); membrane protein
YP_905166.1	cytoplasmic protein
YP_905167.1	membrane protein
YP_905168.1	membrane protein
YP_905169.1	cytoplasmic protein; function unknown, lipolytic enzyme probably involved in cellular metabolism.
YP_905170.1	Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA
YP_905171.1	cytoplasmic protein; function unknown, but involved in lipid degradation.
YP_905172.1	cytoplasmic protein
YP_905173.1	membrane protein; function unknown, but involvement in lipid degradation.
YP_905174.1	membrane protein; possibly involved in transcriptional mechanism.
YP_905175.1	Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA
YP_905176.1	membrane protein; thought to oxidize a wide variety of aliphatic and aromatic aldehydes.
YP_905177.1	membrane protein; causes methylation
YP_905178.1	cytoplasmic protein; function unknown, contains a glycosyltransferase domain (cell envelope biogenesis, outer membrane)
YP_905179.1	membrane protein
YP_905180.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_905181.1	membrane protein; function unknown, probably involved in cellular metabolism.
YP_905182.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_905183.1	cytoplasmic protein
YP_905184.1	cytoplasmic protein
YP_905185.1	cytoplasmic protein
YP_905186.1	cytoplasmic protein
YP_905187.1	cytoplasmic protein
YP_905188.1	cytoplasmic protein
YP_905189.1	membrane protein
YP_905190.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_905191.1	membrane protein
YP_905192.1	membrane protein
YP_905193.1	Detected in the cytoplasmic and secreted fractions by 2D-LC-MS/MS.; secreted protein
YP_905194.1	cytoplasmic protein
YP_905195.1	membrane protein
YP_905196.1	PE_PGRS30; secreted protein
YP_905197.1	cytoplasmic protein; required for the transposition of the insertion element IS2606.
YP_905198.1	cytoplasmic protein
YP_905199.1	secreted protein
YP_905200.1	cytoplasmic protein; enzymatic activity is not yet known [catalytic activity: aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol]
YP_905201.1	function unknown, but involved in lipid degradation.
YP_905202.1	cytoplasmic protein; involved in transcriptional mechanism.
YP_905203.1	NADP-dependent semialdehyde dehydrogenase; part of alternative pathway from alpha-ketoglutarate to succinate
YP_905204.1	membrane protein
YP_905205.1	membrane protein
YP_905206.1	membrane protein
YP_905207.1	cytoplasmic protein; glycerophosphoryl diester phosphodiesterase hydrolyzes deacylated phospholipids to G3P and the corresponding alcohols [catalytic activity: a glycerophosphodiester + H(2)O = an alcohol + SN-glycerol 3- phosphate]
YP_905208.1	secreted protein
YP_905209.1	membrane protein
YP_905210.1	Detected in the membrane fraction by proteomics (LC- MS/MS); secreted protein
YP_905211.1	secreted protein
YP_905212.1	secreted protein
YP_905213.1	cytoplasmic protein; possibly involved in transcriptional mechanism.
YP_905214.1	membrane protein; function unknown, possibly ion channel involved in transport of chloride across the membrane.
YP_905215.1	Detected in the membrane fraction by proteomics (2D- LC-MS/MS) Also detected in the cytoplasmic fraction.; membrane protein
YP_905216.1	Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis
YP_905217.1	Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation
YP_905218.1	Detected in the cytoplasmic fraction by proteomics.; cytoplasmic protein; function unknown, but involved in lipid degradation.
YP_905219.1	cytoplasmic protein; function unknown, probably involved in cellular metabolism.
YP_905220.1	cytoplasmic protein
YP_905221.1	catalyzes the fumarate and succinate interconversion; fumarate reductase is used under anaerobic conditions with glucose or glycerol as carbon source
YP_905222.1	part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol
YP_905223.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; could be involved in interconversion of fumarate and succinate (aerobic respiration) this hydrophobic component may be required to anchor the catalytic components of the succinate dehydrogenase complex to the cytoplasmic membrane.
YP_905224.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_905225.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_905226.1	cytoplasmic protein
YP_905227.1	cytoplasmic protein; thought to be involved in the initiation step of translation at high temperature. bound to 30S ribosomal subunit. possibly a molecular chaperone. in M. tuberculosis H37Rv seems to be regulated positively by SigE and negatively by HspR.
YP_905228.1	cytoplasmic protein; involved in nitrate assimilation (denitrification); required for activity of the reductase [catalytic activity: 3 NAD(P)H + nitrite = 3 NAD(P)+ + NH4OH + H2O]
YP_905230.1	cytoplasmic protein
YP_905231.1	catalyzes the formation of uroporphyrinogen-III from hydroxymethylbilane
YP_905232.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; confers resistance to aminoglycosides (gentamicin, tobramycin, dibekacin, netilmicin, and 6'-N- ethylnetilmicin)
YP_905233.1	cytoplasmic protein
YP_905234.1	cytoplasmic protein
YP_905235.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; thought to be involved in iron transport across the membrane (import)
YP_905236.1	membrane protein; involved in excretion of nitrite produced by the dissimilatory reduction of nitrate. responsible for the translocation of the substrate across the membrane.
YP_905237.1	cytoplasmic protein
YP_905238.1	activates fatty acids by binding to coenzyme A
YP_905239.1	membrane protein
YP_905240.1	cytoplasmic protein; function unknown, but involved in lipid degradation.
YP_905241.1	cytoplasmic protein; involved at the first committed step in the 'phosphorylated' pathway of L-serine biosynthesis [catalytic activity: 3-phosphoglycerate + NAD(+) = 3- phosphohydroxypyruvate + NADH]
YP_905242.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_905243.1	cytoplasmic protein; could be involved in transcriptional mechanism.
YP_905244.1	Detected in the membrane fraction by proteomics (2D- LC-MS/MS); cytoplasmic protein
YP_905245.1	membrane protein
YP_905246.1	cytoplasmic protein; could be involved in transcriptional mechanism.
YP_905248.1	PPE3; secreted protein
YP_905249.1	cytoplasmic protein
YP_905250.1	Detected in the cytoplasmic and the membrane fraction by 2D-LC-MS/MS.; cytoplasmic protein
YP_905251.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_905252.1	membrane protein
YP_905253.1	PE5; Detected in the secreted fraction by proteomics.; secreted protein
YP_905254.1	PPE4; membrane protein
YP_905255.1	secreted protein
YP_905256.1	membrane protein
YP_905257.1	Detected in the membrane fraction by proteomics.; cytoplasmic protein
YP_905258.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_905259.1	Detected in the membrane fraction by proteomics (LC- MS/MS) Also detected in the cytoplasm by proteomics.; membrane protein; thought to have proteolytic activity.
YP_905260.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_905261.1	membrane protein
YP_905262.1	catalyzes the formation of (E)-3-(methoxycarbonyl)pent-2-enedioate and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and trans-aconitate
YP_905263.1	cytoplasmic protein; function unknown, probably involved in cellular metabolism.
YP_905264.1	cytoplasmic protein; function unknown, probably involved in cellular metabolism.
YP_905265.1	Detected in the membrane fraction by proteomics; membrane protein
YP_905266.1	membrane protein
YP_905267.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein
YP_905268.1	membrane protein
YP_905269.1	secreted protein
YP_905270.1	cytoplasmic protein
YP_905271.1	cytoplasmic protein
YP_905272.1	membrane protein
YP_905273.1	membrane protein
YP_905274.1	cytoplasmic protein
YP_905275.1	cytoplasmic protein; function unknown, but seems involved in metabolism of small branched-chain fatty acids and macrolide antibiotic production. catalyses the alpha, beta- dehydrogenetion of acyl-CoA esters and transfer electrons to ETF, the electron transfer protein.
YP_905277.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_905278.1	membrane protein; thought to be involved in active transport of undeterminated substrate (possibly lipooligosaccharide) across the membrane. responsible for energy coupling to the transport system and for the translocation of the substrate across the membrane.
YP_905279.1	cytoplasmic protein
YP_905280.1	membrane protein; probably involved in active transport accross the membrane. thought to be responsible for energy coupling to the transport system and the translocation of the substrate across the membrane.
YP_905281.1	membrane protein
YP_905282.1	cytoplasmic protein; involved in transcriptional mechanism.
YP_905283.1	cytoplasmic protein
YP_905284.1	cytoplasmic protein; involved in arginine metabolism [catalytic activity: L-ornithine + a 2-OXO acid = L-glutamate 5- semialdehyde + an L-amino acid]
YP_905285.1	membrane protein; thought to be involved in transport of cationic amino acid (especially arginine and ornithine) across the membrane. responsible for the translocation of the substrate across the membrane.
YP_905286.1	Detected in the membrane fraction by proteomics (LC- MS/MS); cytoplasmic protein
YP_905287.1	membrane protein; thought to be involved in active transport of sugar across the membrane (import)
YP_905288.1	secreted protein; thought to be involved in active transport of sugar across the membrane (import) responsible for the translocation of the substrate across the membrane.
YP_905289.1	Also detected in the cytoplasm by proteomics.; membrane protein; thought to be involved in active transport of sugar across the membrane (import) responsible for the translocation of the substrate across the membrane.
YP_905290.1	Detected in the membrane fraction by proteomics (2D- LC-MS/MS) Two isoforms were also detected in the cytoplasm.; membrane protein
YP_905291.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; membrane protein
YP_905292.1	secreted protein
YP_905293.1	cytoplasmic protein
YP_905294.1	membrane protein; metal cation-transporting ATPase; possibly catalyzes the transport of a undeterminated metal cation with the hydrolyse of ATP [catalytic activity: ATP + H(2)O + undeterminated metal cation(in) = ADP + phosphate + undeterminated metal cation(out)]
YP_905295.1	cytoplasmic protein
YP_905296.1	cytoplasmic protein
YP_905297.1	cytoplasmic protein; function unknown.
YP_905298.1	cytoplasmic protein
YP_905299.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_905300.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_905301.1	cytoplasmic protein; required for the transposition of the insertion element IS2606.
YP_905302.1	cytoplasmic protein; contains PTPS, 6-pyruvoyl tetrahydropterin synthase domain. 6-pyruvoyl tetrahydrobiopterin synthase catalyses the conversion of dihydroneopterin triphosphate to 6- pyruvoyl tetrahydropterin, the second of three enzymatic steps in the synthesis of tetrahydrobiopterin from GTP. the functional enzyme is a hexamer of identical subunits.
YP_905303.1	cytoplasmic protein
YP_905304.1	cytoplasmic protein
YP_905305.1	cytoplasmic protein; required for the transposition of the insertion element IS2606.
YP_905306.1	membrane protein; function unknown, predicted hydrolase (had superfamily) domain.
YP_905307.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; function unknown, in general, cation channels are transport proteins responsible for the movement of cations through the membrane.
YP_905308.1	Potential pseudogene due to a point mutation, removing a stop codon and now the CDS overlaps the C-term of a CDS on the opposite strand.; membrane protein
YP_905309.1	membrane protein
YP_905310.1	cytoplasmic protein
YP_905311.1	secreted protein
YP_905312.1	cytoplasmic protein
YP_905313.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_905314.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_905315.1	cytoplasmic protein
YP_905316.1	Also detected in the membrane fraction by proteomics (LC-MS/MS); cytoplasmic protein; possibly catalyzes the oxidative deamination: oxidize on primary amines, and perhaps on secondary and tertiary amines [catalytic activity: RCH(2)NH(2) + H(2)O + O(2) = RchO + NH(3) + H(2)O(2)] must have important function in metabolism. supposed involved in stationary- phase survival.
YP_905317.1	cytoplasmic protein; cytochromes P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
YP_905318.1	cytoplasmic protein; function unknown.
YP_905319.1	cytoplasmic protein
YP_905320.1	Detected in the membrane and cytoplamic fractions by proteomics.; cytoplasmic protein; oxidoreduction
YP_905321.1	secreted protein; function unknown; thought to be involved in lipid metabolism.
YP_905322.1	membrane protein; function unknown.
YP_905323.1	cytoplasmic protein
YP_905324.1	Detected in the membrane fraction by proteomics (2D- LC-MS/MS); secreted protein; oxido-reduction
YP_905325.1	cytoplasmic protein; possibly involved in transcriptional regulation
YP_905326.1	cytoplasmic protein
YP_905327.1	cytoplasmic protein
YP_905328.1	involved in the biosynthesis of phosphatidylinositol mannosides (PIMs); the enzyme from Mycobacterium tuberculosis can phosphorylate a variety of amphipathic lipids
YP_905329.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; electron acceptor
YP_905330.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; possibly involved in transcriptional regulation
YP_905331.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; involved in aerobic respiration and oxydation of glycerol. reduces an acceptor and generates glycerone phosphate from SN-glycerol 3-phosphate. possibly play a role in metabolism of riboflavin, fad,FMN [catalytic activity: SN-glycerol 3-phosphate + acceptor = glycerone phosphate + reduced acceptor]
YP_905332.1	cytoplasmic protein
YP_905333.1	Detected in the membrane fraction by proteomics; membrane protein; involved in fatty acid biosynthesis (mycolic acids synthesis) [catalytic activity: ATP + propionyl-CoA + CO(2) + H(2)O = ADP + orthophosphate + methylmalonyl- CoA]
YP_905334.1	FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP
YP_905335.1	FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP
YP_905336.1	carries the fatty acid chain in fatty acid biosynthesis
YP_905337.1	membrane protein; catalyzes malonyl-CoA-acp transacylase (McaT) activity using holo-AcpM as substrate for transacylation [catalytic activity: malonyl-CoA + [acyl-carrier protein] = CoA + malonyl-[acyl-carrier protein]
YP_905338.1	cytoplasmic protein
YP_905339.1	E1 component; part of pyruvate dehydrogenase; forms a complex with DlaT and LpdC
YP_905340.1	N-term truncated (missing first 69aa) wrt to M. tuberculosis; membrane protein
YP_905341.1	cytoplasmic protein
YP_905342.1	cytoplasmic protein; detoxification of organic peroxides.
YP_905343.1	cytoplasmic protein
YP_905344.1	membrane protein; function unknown, possibly involved in transport of metal ions across the membrane.
YP_905345.1	cytoplasmic protein
YP_905346.1	CobD; CbiD in Salmonella; converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
YP_905347.1	membrane protein; function unknown: may be involved in the ability to survive in macrophages.
YP_905348.1	cytoplasmic protein; involved in signal transduction (via dephosphorylation) can dephosphorylated in vitro the phosphotyrosine residue of myelin basic protein (MBP) at ph 7.0 [catalytic activity: protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
YP_905349.1	cytoplasmic protein
YP_905350.1	cytoplasmic protein; involved in cobalamin biosynthesis
YP_905351.1	cytoplasmic protein
YP_905352.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein
YP_905353.1	cytoplasmic protein
YP_905354.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS; cytoplasmic protein
YP_905355.1	membrane protein
YP_905356.1	catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate
YP_905357.1	secreted protein; function unknown; thought to hydrolyze peptides and/or proteins.
YP_905358.1	membrane protein; cytochrome C oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. electrons originating in cytochrome C are transferred via the copper a center of subunit 2 and HemE a of subunit 1 to the bimetallic center formed by HemE A3 and copper B [catalytic activity: 4 ferrocytochrome C + O(2) = 2 H(2)O + 4 ferricytochrome C]
YP_905359.1	secreted protein; function unknown; thought to hydrolyze peptides and/or proteins.
YP_905360.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; involved in glutamine biosynthesis [catalytic activity: ATP + L-glutamate + NH(3) = ADP + glutamine + orthophosphate]
YP_905361.1	catalyzes the ATP-dependent addition of AMP to a subunit of glutamine synthetase; also catalyzes the reverse reaction - deadenylation; adenylation/deadenylation of glutamine synthetase subunits is important for the regulation of this enzyme
YP_905362.1	cytoplasmic protein; function unknown, probably involved in cellular metabolism.
YP_905363.1	membrane protein; function unknown. has fibronectin-binding activity (could thus mediate bacterial attachment to host cells) thought to be expressed during infection.
YP_905364.1	Detected in the membrane fraction by proteomics (LC- MS/MS); cytoplasmic protein; involved in glutamine biosynthesis [catalytic activity: ATP + L-glutamate + NH(3) = ADP + glutamine + orthophosphate]
YP_905365.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_905366.1	membrane protein
YP_905367.1	catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group
YP_905368.1	lipoyl/octanoyltransferase; catalyzes the transfer of the lipoyl/octanoyl moiety of lipoyl/octanoyl-ACP onto lipoate-dependent enzymes like pyruvate dehydrogenase and the glycine cleavage system H protein
YP_905369.1	membrane protein; thought to be involved in active transport of drugs across the membrane (export): multidrugs resistance by an export mechanism. responsible for energy coupling to the transport system and for the translocation of the substrate across the membrane.
YP_905370.1	membrane protein
YP_905371.1	membrane protein; involved in valine and isoleucine biosynthesis (at the first step) [catalytic activity: 2-acetolactate + CO(2) = 2 pyruvate]
YP_905372.1	cytoplasmic protein; function unknown, may have methyltransferase activity
YP_905373.1	cytoplasmic protein
YP_905374.1	cytoplasmic protein
YP_905375.1	cytoplasmic protein; the sigma factor is an initiation factor that promotes attachment of the RNA polymerase to specific initiation sites and then is released.
YP_905376.1	cytoplasmic protein
YP_905377.1	secreted protein
YP_905378.1	cytoplasmic protein; required for the transposition of the insertion element IS2606.
YP_905379.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_905380.1	membrane protein
YP_905381.1	catalyzes the formation of inosine from adenosine
YP_905382.1	Catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate
YP_905383.1	Reclaims exogenous and endogenous cytidine and 2'-deoxycytidine molecules for UMP synthesis
YP_905384.1	membrane protein; involved in tricarboxylic acid cycle. mono-heme cytochrome of the succinate dehydrogenase complex.
YP_905385.1	membrane protein; involved in tricarboxylic acid cycle. putative hydrophobic component of the succinate dehydrogenase complex. could be required to anchor the catalytic components to the cytoplasmic membrane.
YP_905386.1	part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol
YP_905387.1	part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase
YP_905388.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_905389.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_905390.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_905391.1	Detected in the membrane fraction by proteomics (LC- MS/MS); cytoplasmic protein; involved in base excision repair. apurinic- apyrimidinic endonuclease. supposed to remove the damaged DNA at cytosines and guanines by cleaving at the 3' side of the ap site by a beta-elimination reaction. possibly exhibites 3'-5'-exonuclease, 3'-phosphomonoesterase, 3'- repair diesterase and ribonuclease H activities [catalytic activity: degradation of double-stranded DNA. it acts progressively in a 3'- to 5'-direction, releasing 5'- phosphomononucleotides]
YP_905392.1	cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+)
YP_905393.1	cytoplasmic protein
YP_905394.1	Detected in the membrane fraction and secreted fractions by proteomics. (2D-LC-MS/MS); membrane protein
YP_905395.1	Detected in the membrane fraction by proteomics; secreted protein; destroys radicals which are normally produced within the cells and are toxic to biological systems [catalytic activity: 2 superoxide + 2 H+ = O2 + H2O2]
YP_905396.1	ATP-dependent carboxylate-amine ligase
YP_905397.1	cytoplasmic protein; involved in transcriptional mechanism.
YP_905398.1	membrane protein; function unknown, possibly involved in inorganic ion transport.
YP_905399.1	cytoplasmic protein
YP_905400.1	membrane protein; ATPase; possibly catalyzes the transport of undeterminated substrate with hydrolyse of ATP [catalytic activity: ATP + H(2)O + undeterminated substrate(in) = ADP + phosphate + undeterminated substrate(out)]
YP_905401.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; involved in phospholipid biosynthesis. generates phosphatidylserine [catalytic activity: CDP-diacylglycerol + L-serine = CMP + O-SN-phosphatidyl-L-serine]
YP_905402.1	catalyzes the decarboxylaton of phospatidyl-L-sering to phosphatidylethanolamine
YP_905403.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_905404.1	cytoplasmic protein; involved in molybdenum cofactor biosynthesis: involved in the biosynthesis of a demolybdo-cofactor (molybdopterin), necessary for molybdo-enzymes (by similarity)
YP_905405.1	cytoplasmic protein; function unknown, possibly involved in cellular metabolism.
YP_905406.1	cytoplasmic protein
YP_905407.1	60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth
YP_905408.1	cytoplasmic protein
YP_905409.1	PPE10; membrane protein
YP_905410.1	cytoplasmic protein; hydrolizes a specific D-amino acid.
YP_905411.1	cytoplasmic protein
YP_905412.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_905413.1	membrane protein
YP_905414.1	Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; in M. bovis this protein has been shown to be involved in expression of antigenic proteins
YP_905415.1	membrane protein
YP_905416.1	cytoplasmic protein; transfers a methylene group from S-adenosyl-L- methionine to the cis double bond of an unsaturated fatty acid chain resulting in the replacement of the double bond with a methylene bridge [catalytic activity: S-adenosyl-L- methionine + phospholipid olefinic fatty acid = S-adenosyl- L-homocysteine + phospholipid cyclopropane fatty acid]
YP_905417.1	cytoplasmic protein
YP_905418.1	membrane protein
YP_905419.1	cytoplasmic protein; required for the transposition of the insertion element IS2606.
YP_905420.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_905421.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_905422.1	cytoplasmic protein; required for the transposition of the insertion element IS2606.
YP_905423.1	cytoplasmic protein
YP_905424.1	Detected in the secreted protein fraction by 2D-LC- MS/MS.; secreted protein
YP_905425.1	catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA
YP_905426.1	cytoplasmic protein; interconversion aldehyde and acid [catalytic activity: an aldehyde + NAD+ + H2O = an acid + NADH]
YP_905427.1	cytoplasmic protein
YP_905428.1	membrane protein
YP_905429.1	membrane protein
YP_905430.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_905431.1	cytoplasmic protein; function unknown, probably involved in cellular metabolism.
YP_905432.1	membrane protein; thought to be involved in active transport of undeterminated substrate (possibly lipooligosaccharide) across the membrane. responsible for energy coupling to the transport system and for the translocation of the substrate across the membrane.
YP_905433.1	catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate
YP_905434.1	membrane protein
YP_905435.1	Detected in the secreted fraction by proteomics.; secreted protein
YP_905436.1	secreted protein; function unknown, probably involved in cellular metabolism.
YP_905437.1	activates fatty acids by binding to coenzyme A
YP_905438.1	secreted protein
YP_905439.1	secreted protein
YP_905440.1	cytoplasmic protein; causes methylation
YP_905441.1	Catalyzes the conversion of acetyl-CoA and L-homoserine to CoA and O-acetyl-L-homoserine
YP_905442.1	catalyzes the formation of L-methionine and acetate from O-acetyl-L-homoserine and methanethiol
YP_905443.1	membrane protein
YP_905444.1	catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
YP_905445.1	membrane protein
YP_905446.1	membrane protein; involved in N-acetyl glucosamine utilization pathway [catalytic activity: N-acetyl-D-glucosamine 6- phosphate + H(2)O = D-glucosamine 6-phosphate + acetate]
YP_905447.1	membrane protein; thought to be involved in transport of sugar across the membrane. responsible for the translocation of the substrate across the membrane.
YP_905448.1	secreted protein; involved in peptidoglycan synthesis (at final stages) hydrolyzes the bound D-alanyl-D-alanine [catalytic activity: D-alanyl-D-alanine + H(2)O = 2 D- alanine]
YP_905449.1	secreted protein
YP_905450.1	cytoplasmic protein; possible inter-alpha-trypsin inhibitor family heavy chain-related protein-hypothetical secreted or membrane- associated protein containing vWFA domain.
YP_905451.1	membrane protein
YP_905452.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_905453.1	Detected in the cytoplasmic and membrane fractions by 2D-LC-MS/MS.; secreted protein
YP_905454.1	Also detected in the cytoplasmic fraction by 2D-LC- MS/MS.; secreted protein
YP_905455.1	dGTPase family type 2 subfamily; presumably hydrolyzes dGTP to deoxyguanosine and triphosphate
YP_905456.1	synthesizes RNA primers at the replication forks
YP_905458.1	secreted protein; function unknown, contains N-term signal peptide indicative of secreted protein.
YP_905459.1	secreted protein; thioredoxin participates in various redox reactions through the reversible oxidation of its active center dithiol, to a disulfide, & catalyzes dithiol-disulfide exchange reactions.
YP_905460.1	cytoplasmic protein; involved in cysteine biosynthesis [catalytic activity: acetyl-CoA + L-serine = CoA + O-acetyl-L- serine]
YP_905461.1	Also detected in the membrane fraction by proteomics.; cytoplasmic protein; involved in cysteine biosynthesis [catalytic activity: O3-acetyl-L-serine + H(2)S = L-cysteine + acetate]
YP_905463.1	malic enzyme; oxaloacetate-decarboxylating; NAD-dependent; catalyzes the formation of pyruvate form malate
YP_905464.1	membrane protein; thought to be involved in a transport system across the membrane (perhaps drug transport): responsible for the translocation of the substrate across the membrane.
YP_905465.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_905466.1	cytoplasmic protein; required for the transposition of the insertion element IS2606.
YP_905467.1	membrane protein; thought to play an essential roles in regulation of cellular metabolism by catalysing the synthesis of a second messenger, camp [catalytic activity: ATP = 3',5'- cyclic AMP + pyrophosphate]
YP_905468.1	cytoplasmic protein; decomposes formic acid to hydrogen and carbon dioxide under anaerobic conditions in the absence of exogenous electron acceptors [catalytic activity: formate + NAD(+) = CO(2) + NADH]
YP_905469.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_905470.1	membrane protein; cation-transporting ATPase; possibly catalyzes the transport of a cation (possibly cadmium) with the hydrolyse of ATP [catalytic activity: ATP + H(2)O + cation(in) = ADP + phosphate + cation(out)]
YP_905471.1	cytoplasmic protein; thioredoxin participates in various redox reactions through the reversible oxidation of its active center dithiol, to a disulfide, & catalyzes dithiol-disulfide exchange reactions.
YP_905472.1	cytoplasmic protein; thioredoxin participates in various redox reactions through the reversible oxidation of its active center dithiol, to a disulfide, & catalyzes dithiol-disulfide exchange reactions.
YP_905473.1	Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA
YP_905474.1	membrane protein; probable macrolide-transport ATP-binding protein ABC transporter. thought to be involved in active transport of macrolide across the membrane.
YP_905475.1	cytoplasmic protein; involved in transcriptional mechanism.
YP_905476.1	cytoplasmic protein; involved in transcriptional mechanism.
YP_905477.2	Catalyzes the conversion of citrate to isocitrate
YP_905478.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_905479.1	secreted protein; function unknown, similar to a hypothetical invasion protein. possibly an exported protein with unusually long signal sequence. NLP/P60 family protein
YP_905480.1	secreted protein; function unknown. homology to cell wall-associated hydrolases. possibly an exported protein of the NLP/P60 family.
YP_905481.1	Detected in the cytoplamic and membrane fractions by LC-MS/MS. Also detected in the extracellular matrix by proteomics.; membrane protein; involved in transcriptional mechanism.
YP_905482.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_905483.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_905484.1	Detected in the membrane fraction by proteomics (LC- MS/MS) Also detected in the cytoplasmic fraction by 2D-LC- MS/MS.; membrane protein; involved in the fatty acid biosynthesis pathway (first reduction step) (mycolic acid biosynthesis); reduces KasA/KasB products [catalytic activity: (3R)-3- hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl- [acyl-carrier protein] + NADPH]
YP_905485.1	Catalyzes a key regulatory step in fatty acid biosynthesis
YP_905486.1	protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic
YP_905487.1	cytoplasmic protein
YP_905488.1	cytoplasmic protein; required for the transposition of insertion element IS2606
YP_905489.1	membrane protein; function unknown. contains Cdd match to COG1585, COG1585, membrane protein implicated in regulation of membrane protease activity [posttranslational modification, protein turnover, chaperones / intracellular trafficking and secretion]
YP_905490.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_905491.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_905492.1	cytoplasmic protein; involved in transcriptional mechanism.
YP_905493.1	cytoplasmic protein; contains N-terminal Cdd pfam00072, response_reg, response regulator receiver domain. this domain receives the signal from the sensor partner in bacterial two- component systems. it is usually found N-terminal to a DNA binding effector domain. C-terminal conatins Cdd pfam00486, trans_reg_C, transcriptional regulatory protein, C terminal.
YP_905494.1	membrane protein; two component system response sensor kinase contains Cdd pfam02518, hATPase_C, histidine kinase-, DNA gyrase B-, and Hsp90-like ATPase; Cdd pfam00512, HisKA, His kinase a (phosphoacceptor) domain. dimerisation and phosphoacceptor domain of histidine kinases.
YP_905495.1	membrane protein
YP_905496.1	membrane protein; conserved membrane protein of unknown function. similar to proteins from many organisms containing Cdd COG0398; uncharacterized conserved protein [function unknown]
YP_905497.1	membrane protein; involved in propionic acid fermentation. catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid- cycle intermediates [catalytic activity: (R)-2-methyl-3- oxopropanoyl-CoA = succinyl- CoA]
YP_905498.1	MDM; functions in conversion of succinate to propionate
YP_905499.1	functions in transport of arginine/ornithine; inner membrane ATPase that cleaves ATP and phosphorylates two periplasmic proteins that function as two distinct transport systems, the AO (arginine and ornithine) and LAO (lysine, arginine, and ornithine) periplasmic binding proteins
YP_905500.1	cytoplasmic protein; function unknown. contains Cdd pfam07311, DUF1458, protein of unknown function (DUF1458) this family consists of several hypothetical bacterial proteins as well as one archaeal sequence. members of this family are typically of around 70 residues in length. the function of this family is unknown.
YP_905501.1	cytoplasmic protein
YP_905502.1	cytoplasmic protein; possibly involved in polysaccharide biosynthesis [catalytic activity: UDP-glucose + 2 NAD+ + H2O = UDP- glucuronate + 2 NADH] belongs to  UDP-glucose/GDP-mannose dehydrogenase family
YP_905503.1	cytoplasmic protein; involved in galactofuranosyl biosynthesis: converts UDO-GlcP to UDP-GalP [catalytic activity: UDP- glucopyranose = UDP-galactopyranose]
YP_905504.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_905505.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_905506.1	cytoplasmic protein; required for the transposition of the insertion element IS2606.
YP_905507.1	cytoplasmic protein
YP_905508.1	cytoplasmic protein
YP_905509.1	membrane protein; possibly involved in cell wall arabinogalactan linker formation: uses dTDP-L-rhamnose as substrate to insert the rhamnosyl residue into the cell wall
YP_905510.1	cytoplasmic protein; function unknown.contains Cdd pfam00535, glycos_transf_2, glycosyl transferase. diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.
YP_905511.1	membrane protein
YP_905512.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_905513.1	membrane protein; function unknown. contains Cdd COG1819, glycosyl transferases, related to UDP-glucuronosyltransferase [carbohydrate transport and metabolism / signal transduction mechanisms]
YP_905514.1	membrane protein; function unknown. similarity to Cdd pfam03007. uncharacterised protein family (UPF0089) this family of uncharacterised proteins is greatly expanded in mycobacterium tuberculosis. the most conserved region of the proteins contains conserved histidine and aspartate residues suggesting a possible metal binding site suggestive of a protease activity.
YP_905515.1	cytoplasmic protein; function unknown. thought to be involved in lipid metabolism.
YP_905516.1	IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 2 subfamily; some organisms carry two different copies of this enzyme; in some organisms, the type 2 subfamily is associated with resistance to the antibiotic pseudomonic acid (mupirocin)
YP_905517.1	cytoplasmic protein; function unknown. partial Cdd  COG0030, KsgA, dimethyladenosine transferase (rRNA methylation) [translation, ribosomal structure and biogenesis]
YP_905518.1	involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function
YP_905519.1	cytoplasmic protein; conversion of asparagine to aspartate
YP_905520.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; this protein specifically catalyzes the removal of signal peptides from prolipoproteins [catalytic activity : cleavage of N-terminal leader sequences from membrane prolipoproteins
YP_905521.1	membrane protein; pseudouridine synthase (pseudouridylate synthase) (uracil hydrolyase)[catalytic activity] uracil + D-ribose 5-phosphate = pseudouridine 5'-phosphate + H(2)O.
YP_905522.1	cytoplasmic protein; function unknown. contains partial Cdd COG2226, UbiE, methylase involved in ubiquinone/menaquinone biosynthesis
YP_905523.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; function unknown.
YP_905524.1	cytoplasmic protein; oxygen transport.  this family of HemE binding proteins are found mainly in bacteria.
YP_905525.1	Detected in the cytoplasmic fraction; membrane protein; possibly involvement in lipid metabolism
YP_905526.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS. Also detected in the membrane fraction by proteomics (2D-LC-MS/MS); cytoplasmic protein
YP_905527.1	catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase
YP_905528.1	membrane protein; probably involved in lipid degradation
YP_905529.1	PlsB; catalyzes the formation of 1-acyl-sn-glycerol 3-phosphate by transfering the acyl moiety from acyl-CoA
YP_905530.1	secreted protein; function unknown.
YP_905531.1	Detected in the cytoplasmic and secreted fractions by 2D-LC-MS/MS.; secreted protein; function unknown. contains Cdd pfam04075, domain of unknown function (DUF385) family of mycobacterium tuberculosis proteins.
YP_905532.1	catalyzes the formation of 2-oxobutanoate from L-threonine; biosynthetic
YP_905533.1	cytoplasmic protein
YP_905534.1	cytoplasmic protein; involved in transcriptional mechanism.
YP_905535.1	cytoplasmic protein; involved in trehalose biosynthesis (protective effect) mycobacteria can produce trehalose from glucose 6- phosphate and UDP-glucose (the OtsA-OtsB pathway) from glycogen-like alpha(1-->4)-linked glucose polymers (the TreY-TreZ pathway) and from maltose (the TreS pathway)
YP_905536.1	membrane protein; involved in trehalose biosynthesis (protective effect) mycobacteria can produce trehalose from glucose 6- phosphate and UDP-glucose (the OtsA-OtsB pathway) from glycogen-like alpha(1-->4)-linked glucose polymers (the TreY-TreZ pathway)
YP_905537.1	cytoplasmic protein; possibly involved in trehalose biosynthesis (protective effect) mycobacteria can produce trehalose from glucose 6-phosphate and UDP-glucose (the OtsA-OtsB pathway) from glycogen-like alpha(1-->4)-linked glucose polymers (the TreY-TreZ pathway)
YP_905538.1	membrane protein
YP_905539.1	Detected in the secreted protein fraction by 2D-LC- MS/MS.; secreted protein; possible inv protein, probably exported as has QQAPV repeats at c-terminus.
YP_905540.1	membrane protein
YP_905541.1	catalyzes the formation of S-adenosyl-4-methylthionine-2-oxobutanoate and 7,8-diaminononanoate from S-adenosyl-L-methionine and 8-amino-7-oxononanoate
YP_905542.1	catalyzes the formation of 8-amino-7-oxononanoate from 6-carboxyhexanoyl-CoA and L-alanine
YP_905543.1	DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium
YP_905544.1	membrane protein
YP_905545.1	catalyzes the formation of biotin from dethiobiotin and sulfur 2 S-adenosyl-L-methionine
YP_905546.1	cytoplasmic protein
YP_905547.1	membrane protein
YP_905548.1	membrane protein
YP_905549.1	cytoplasmic protein; function unknown, domain identity to ADP-ribose pyrophosphatases, possible role in nucleotide transport and metabolism.
YP_905550.1	3 different subfamilies; catalyzes the formation of quinolinate from iminoaspartate and dihydroxyacetone phosphate
YP_905551.1	catalyzes the formation of oxaloacetate from L-aspartate
YP_905552.1	catalyzes the formation of pyridine-2,3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate from nictinate D-ribonucleotide
YP_905553.1	cytoplasmic protein
YP_905554.1	catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer
YP_905555.1	catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis
YP_905556.1	catalyzes the dehydration of D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate to 3-(imidazol-4-yl)-2-oxopropyl phosphate in histidine biosynthesis
YP_905557.1	with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide
YP_905558.1	catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide and the formation of 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate from N-(5-phospho-beta-D-ribosyl)anthranilate; involved in histidine and tryptophan biosynthesis
YP_905559.1	cytoplasmic protein; involved in inositol phosphate metabolism. it is responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides. key enzyme of the phosphatidyl inositol signaling pathway [catalytic activity: inositol 1(or 4)-monophosphate + H(2)O = inositol + orthophosphate]
YP_905560.1	catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase
YP_905561.1	PR-AMP cyclohydrolase; functions in histidine biosynthesis from PRPP; converts 1-(5-phosphoribosyl)-AMP to 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxyamide during the histidine biosynthesis pathway; binds zinc and magnesium; forms homodimers
YP_905562.1	cytoplasmic protein; function unknown.
YP_905563.1	cytoplasmic protein; required for the transposition of the insertion element IS2606.
YP_905564.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_905565.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; peroxide detoxification
YP_905566.1	with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine
YP_905567.1	membrane protein
YP_905568.1	involved in tryptophan biosynthesis; amino acid biosynthesis; converts 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate to C(1)-(3-indolyl)-glycerol 3-phosphate and carbon dioxide and water
YP_905569.1	catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate
YP_905570.1	catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis
YP_905571.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_905572.1	membrane protein
YP_905573.1	secreted protein; hydrolysis of cutin.
YP_905574.1	catalyzes the formation of phosphoenolpyruvate from pyruvate
YP_905575.1	cytoplasmic protein; involved in fatty acid metabolism.
YP_905576.1	membrane protein
YP_905577.1	secreted protein; involved in active transport across the membrane of component linked with the assembly of cytochrome: involved in cytochrome biogenesis (aerobic respiration) responsible for energy coupling to the transport system and for the translocation of the substrate across the membrane.
YP_905578.1	secreted protein; involved in active transport across the membrane of component linked with the assembly of cytochrome: involved in cytochrome biogenesis (aerobic respiration) responsible for energy coupling to the transport system and for the translocation of the substrate across the membrane.
YP_905579.1	membrane protein; involved in the respiratory chain (at the terminal step): aerobic respiration. cytochrome D terminal oxidase complex is the component of the aerobic respiratory chain that is supposed predominated when cells are grown at low aeration [catalytic activity: ubiquinol-8 + O(2) = ubiquinone-8 + H(2)O]
YP_905580.1	membrane protein
YP_905581.1	Also detected in the extracellular matrix and the membrane fractions by proteomics.; cytoplasmic protein; sensor part of a two component regulatory system
YP_905582.1	cytoplasmic protein
YP_905583.1	has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair
YP_905584.1	in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins
YP_905585.1	catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis; in Mycobacterium tuberculosis the C-terminal UPF0157 domain appears to be necessary for proper folding of the N-terminal domain
YP_905586.1	cytoplasmic protein
YP_905587.1	cytoplasmic protein
YP_905588.1	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion
YP_905589.1	membrane protein; thought to be involved in transport of drug across the membrane (export) drug resistance by an export mechanism (conferes resistance to toxic compounds by removing them for the cells)
YP_905590.1	membrane protein
YP_905591.1	Also detected in the extracellular matrix by proteomics.; cytoplasmic protein; function unknown, domain identity to universal stress protein family and to iron-regulated conserved hypothetical protein TB15.3 from M. tuberculosis H37Rv.
YP_905592.1	Also detected in the extracellular matrix by proteomics.; cytoplasmic protein
YP_905593.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein
YP_905594.1	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
YP_905595.1	cytoplasmic protein
YP_905596.1	membrane protein
YP_905597.1	catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
YP_905598.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
YP_905599.1	cytoplasmic protein; translation
YP_905600.1	binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit
YP_905601.1	cytoplasmic protein; rRNA modification
YP_905602.1	cytoplasmic protein
YP_905603.1	membrane protein
YP_905604.1	cytoplasmic protein
YP_905605.1	membrane protein
YP_905606.1	catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily
YP_905607.1	catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily
YP_905608.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_905609.1	membrane protein; function unknown.
YP_905610.1	membrane protein; function unknown.
YP_905611.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_905612.1	cytoplasmic protein; required for the transposition of the insertion element IS2606.
YP_905613.1	catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate
YP_905614.1	bifunctional arginine biosynthesis protein ArgJ; functions at the 1st and 5th steps in arginine biosynthesis; involved in synthesis of acetylglutamate from glutamate and acetyl-CoA and ornithine by transacetylation between acetylornithine and glutmate
YP_905615.1	catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate
YP_905616.1	catalyzes the formation of N-acetyl-l-glutamate 5-semialdehyde from 2-oxoglutarate and N(2)-acetyl-L-ornithine
YP_905617.1	catalyzes the formation of L-citrulline from carbamoyl phosphate and L-ornithine in arginine biosynthesis and degradation
YP_905618.1	regulates arginine biosynthesis when complexed with arginine by binding at site that overlap the promotors of the arginine biosynthesis genes
YP_905619.1	catalyzes the formation of 2-N(omega)-(L-arginino)succinate from L-citrulline and L-aspartate in arginine biosynthesis, AMP-forming
YP_905620.1	catalyzes the formation of arginine from (N-L-arginino)succinate
YP_905621.1	membrane protein
YP_905622.1	membrane protein; possibly involved in the biosynthesis of secondary metabolites [catalytic activity: 3 malonyl-CoA + 4- coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2]
YP_905623.1	cytoplasmic protein; thought to be involved in active transport of macrolide across the membrane (export) macrolide antibiotics resistance by an export mechanism. responsible for energy coupling to the transport system
YP_905624.1	membrane protein; wide specificity for D-amino acids. also acts on glycine [catalytic activity: a D-amino acid + H2O + O2 = a 2-oxo acid + NH3 + H2O2]
YP_905625.1	activates fatty acids by binding to coenzyme A
YP_905626.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein
YP_905627.1	cytoplasmic protein; role in amino acid transport and metabolism
YP_905628.1	cytoplasmic protein; unknwon
YP_905629.1	membrane protein; thought to be involved in active transport of undeterminated substrate (possibly drug) across the membrane. responsible for the translocation of the substrate across the membrane
YP_905630.1	membrane protein; thought to be involved in active transport of undeterminated substrate (possibly drug) across the membrane. responsible for energy coupling to the transport system
YP_905631.1	responsible for recognizing base lesions in the genome and initiating base excision DNA repair
YP_905632.1	catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr)
YP_905633.1	cytoplasmic protein; function unknown. no blast similarities.
YP_905634.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_905635.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_905636.1	membrane protein
YP_905637.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_905638.1	cytoplasmic protein
YP_905639.1	membrane protein
YP_905640.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein
YP_905641.1	cytoplasmic protein; function unknown; probably involved in cellular metabolism
YP_905642.1	cytoplasmic protein
YP_905643.1	cytoplasmic protein; has a contact-dependent haemolytic activity; possibly involved in virulence (pore formation)
YP_905644.1	catalyzes the phosphorylation of NAD to NADP
YP_905645.1	cytoplasmic protein; involved in recombinational repair of damaged DNA.
YP_905646.1	membrane protein
YP_905647.1	secreted protein
YP_905648.1	CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer
YP_905649.1	cytoplasmic protein; NUDIX hydrolases catalyze the hydrolysis of a variety of nucleoside diphosphate derivatives
YP_905650.1	site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; XerD specifically exchanges the bottom strands; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs
YP_905651.1	cytoplasmic protein; catalyzes the O-methylation [catalytic activity: S- adenosyl-L-methionine + catechol = S-adenosyl-L- homocysteine + guaiacol]
YP_905652.1	membrane protein; this is a family of myo-inositol-1-phosphate synthases. inositol-1-phosphate catalyses the conversion of glucose-6- phosphate to inositol-1-phosphate, which is then dephosphorylated to inositol. inositol phosphates play an important role in signal transduction.
YP_905653.1	membrane protein; membrane associated. contains Cdd matches to polyprenyltransferase domains.
YP_905654.1	cytoplasmic protein; contains Cdd COG1082,sugar phosphate isomerases/epimerases [carbohydrate transport and metabolism
YP_905655.1	cytoplasmic protein; contains Cdd COG1099, predicted metal-dependent hydrolases with the TIM-barrel FolD.
YP_905656.1	membrane protein; function unknown.
YP_905657.1	cytoplasmic protein
YP_905658.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_905659.1	Detected in the membrane fraction by proteomics (2D- LC-MS/MS); membrane protein
YP_905660.1	PPE23; membrane protein
YP_905661.1	cytoplasmic protein; thought to be involved in the biogenesis of the hydroxyphenyloxazoline-containing siderophore mycobactins
YP_905662.1	cytoplasmic protein; function unknown, but involved in lipid degradation.
YP_905663.1	cytoplasmic protein
YP_905664.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_905665.1	catalyzes the formation of spermidine from putrescine and S-adenosylmethioninamine
YP_905666.1	membrane protein
YP_905667.1	membrane protein; function unknown, possible membrane protein
YP_905668.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_905669.1	membrane protein
YP_905670.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein
YP_905671.1	endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity
YP_905672.1	plays an essential role in ATP-dependent branch migration of the Holliday junction
YP_905673.1	promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration
YP_905674.1	membrane protein
YP_905675.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; function unknown, domain identity membrane protein Cdd COG3759
YP_905676.1	secreted protein
YP_905677.1	membrane protein
YP_905678.1	cytoplasmic protein; function unknown, but involved in lipid degradation.
YP_905679.1	catalyzes the formation of succinate semialdehyde and glutamate from 4-aminobutanoate and 2-oxoglutarate
YP_905680.1	member of preprotein translocase; forms a heterotrimer with SecD and SecF; links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex
YP_905681.1	part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane
YP_905682.1	forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF
YP_905683.1	secreted protein; function unknown. possible COG0747, DdpA, ABC-type dipeptide transport system, periplasmic component [amino acid transport and metabolism]
YP_905684.1	catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis
YP_905685.1	Detected in the cytoplamic fraction by LCMSMS; cytoplasmic protein; involved in the metabolism of PPGPP (at the first step) in eubacteria PPGPP (guanosine 3'-diphosphate 5- 'diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. this enzyme catalyzes the formation of PPPGPP which is then hydrolysed to form PPGPP [catalytic activity: ATP + GTP = AMP + guanosine 3'- diphosphate 5-'triphosphate]
YP_905686.1	Detected in the secreted and membrane fractions by proteomics.; membrane protein; Ppiases accelerate the folding of proteins [catalytic activity: cis-trans isomerization of proline imidic peptide bonds in oligopeptides]
YP_905687.1	cytoplasmic protein; involved in glyoxal pathway. thioesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid [catalytic activity: (S)-(2-hydroxyacyl)glutathione + H(2)O = glutathione + a 2- hydroxy acid anion]
YP_905688.1	catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG
YP_905689.1	May be regulated by LexA; cytoplasmic protein
YP_905690.1	Contains patatin domain. This family consists of various patatin glycoproteins from plants. The patatin protein accounts for up to 40% of the total soluble protein in potato tubers. Patatin is a storage protein but it also has the enzymatic activity of lipid acyl hydrolase.; cytoplasmic protein; patatin-like phospholipase catalysing the cleavage of fatty acids from membrane lipids.
YP_905691.1	cytoplasmic protein; function unknown. contains Cdd pfam01381, HTH_3, helix-turn-helix of DNA binding proteins.
YP_905692.1	cytoplasmic protein; involved in biosynthesis of diaminopimelate and lysine from aspartate semialdehyde (at the first step) [catalytic activity: l-aspartate 4-semialdehyde + pyruvate = dihydrodipicolinate + 2 H(2)O]
YP_905693.1	membrane protein
YP_905694.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_905695.1	ketopantoate reductase; catalyzes the NADPH reduction of ketopantoate to pantoate; functions in pantothenate (vitamin B5) biosynthesis
YP_905696.1	catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes
YP_905697.1	cytoplasmic protein
YP_905698.1	cytoplasmic protein; function unknown, but contains Cdd COG1305, transglutaminase-like enzymes, putative cysteine proteases
YP_905699.1	cytoplasmic protein
YP_905700.1	membrane protein
YP_905701.1	cytoplasmic protein; function unknown, in general transglutaminases are enzymes that establish covalent links between proteins. a subset of transglutaminase homologues appear to catalyse the reverse reaction, the hydrolysis of peptide bonds.
YP_905702.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_905703.1	cytoplasmic protein
YP_905704.1	cytoplasmic protein; function unknown, thought to be involved in the persistence in the host.
YP_905705.1	cytoplasmic protein
YP_905706.1	Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
YP_905707.1	similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function
YP_905708.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_905709.1	AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate
YP_905710.1	catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis
YP_905711.1	catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis
YP_905712.1	catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis
YP_905713.1	catalyzes the formation of 3-dehydroshikimate from 3-dehydroquinate in chorismate biosynthesis
YP_905714.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_905715.1	cytoplasmic protein; function unknown, hydrolyses peptides.
YP_905716.1	Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA
YP_905717.1	Regulates rRNA biosynthesis by transcriptional antitermination
YP_905718.1	secreted protein
YP_905719.1	cytoplasmic protein; function unknown, probably involved in cellular metabolism.
YP_905720.1	cytoplasmic protein
YP_905721.1	cytoplasmic protein; function unknown.
YP_905722.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_905723.1	membrane protein
YP_905724.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; membrane protein
YP_905725.1	cytoplasmic protein; involved in sulfation: activity towards typical ceramide glycolipids and trehalose glycolipids.
YP_905726.1	cytoplasmic protein; involved in sulfation: activity towards typical ceramide glycolipids and trehalose glycolipids.
YP_905727.1	regulates pyrimidine biosynthesis by binding to the mRNA of the pyr genes, also has been shown to have uracil phosphoribosyltransferase activity
YP_905728.1	catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis
YP_905729.1	catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis
YP_905731.1	catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers
YP_905732.1	four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity
YP_905733.1	type 2 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase
YP_905734.1	Detected in the cytoplamic fraction by LCMSMS. Also detected in the membrane fraction by proteomics (LC- MS/MS); cytoplasmic protein
YP_905735.1	Essential for recycling GMP and indirectly, cGMP
YP_905736.1	Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits
YP_905737.1	catalyzes the conjugation of cysteine to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, which is then decarboxylated to form 4'-phosphopantotheine
YP_905738.1	catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase
YP_905739.1	secreted protein
YP_905740.1	cytoplasmic protein; function unknown, probably involved in cellular metabolism
YP_905741.1	cytoplasmic protein
YP_905742.1	cytoplasmic protein
YP_905743.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_905744.1	binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity
YP_905745.1	cytoplasmic protein; causes methylation
YP_905746.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_905747.1	cytoplasmic protein; involved in transcriptional mechanism
YP_905748.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; causes methylation
YP_905749.1	modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth
YP_905750.1	cytoplasmic protein
YP_905751.1	catalyzes the interconversion of D-ribulose 5-phosphate to xylulose 5-phosphate
YP_905752.1	Detected in the membrane fraction by proteomics (2D- LC-MS/MS); membrane protein; involved in riboflavin biosynthesis (at the second and third steps) converts 2,5-diamino-6-(ribosylamino)- 4(3H)-pyrimidinone 5'-phosphate into 5-amino-6- (ribosylamino)-2,4(1H,3H)-pyrimidinedione 5'-phosphate [catalytic activity 1: 2,5-diamino-6-hydroxy-4-(5- phosphoribosylamino)pyrimidine + H(2)O = 5-amino-6-(5- phosphoribosylamino)uracil + NH(3)] [catalytic activity 2: 5-amino-6-(5-phosphoribitylamino)uracil + NADP(+) = 5- amino-6-(5-phosphoribosylamino)uracil + NADPH]
YP_905753.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; involved in transport of aminoglycosides and tetracycline across the membrane (export): drug resistance by an export mechanism (conferes resistance to toxic compounds by removing them for the cells) responsible for the translocation of the substrate across the membrane.
YP_905754.1	Detected in the membrane fraction and the cytoplamic fraction by LC.MS/MS.; membrane protein
YP_905755.1	catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine
YP_905756.1	bifunctional enzyme DHBP synthase/GTP cyclohydrolase II; functions in riboflavin synthesis; converts GTP to 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine; converts ribulose 5-phopshate to 3,4-dihydroxy-2-butanone 4-phosphate
YP_905757.1	RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not
YP_905758.1	membrane protein
YP_905759.1	secreted protein
YP_905760.1	May be regulated by LexA; Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein
YP_905761.1	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision
YP_905762.1	cytoplasmic protein
YP_905763.1	Detected in the cytoplamic fraction.; membrane protein
YP_905764.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; involved in transcriptional mechanism
YP_905765.1	cytoplasmic protein
YP_905766.1	Detected in the membrane fraction by proteomics (LC- MS/MS); cytoplasmic protein; function unknown, but supposed involved in lipid metabolism
YP_905767.1	cytoplasmic protein
YP_905768.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_905769.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_905770.1	cytoplasmic protein; function unknown, probably involved in cellular metabolism
YP_905771.1	membrane protein
YP_905772.1	Also detected in the extracellular matrix and the membrane fraction by proteomics.; cytoplasmic protein; involved in second phase of glycolysis (first step) [catalytic activity: D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = 3-phospho-D-glyceroyl phosphate + NADH]
YP_905773.1	Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway
YP_905774.1	Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate
YP_905775.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; possibly involved in transcriptional mechanism.
YP_905776.1	membrane protein
YP_905777.1	membrane protein; involved in protein export. participates in a early event of protein translocation.
YP_905778.1	catalyzes the formation of oxaloacetate from phosphoenolpyruvate
YP_905779.1	secreted protein
YP_905780.1	secreted protein
YP_905781.1	cytoplasmic protein
YP_905782.1	Detected in the cytoplasmic fraction by proteomics.; cytoplasmic protein; involved in pentose phosphate pathway. hydrolysis of 6-phosphogluconolactone to 6- phosphogluconate. [catalytic activity : 6-phospho-D-glucono-1,5-lactone + H(2)O = 6- phospho-D-gluconate]
YP_905783.1	cytoplasmic protein; may be involved in the functional assembly of glucose 6-phosphate dehydrogenase
YP_905784.1	catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate
YP_905785.1	catalyzes the reversible formation of D-erythrose 4-phosphate and D-fructose 6-phosphate from sedoheptulose 7-phosphate and D-glyceraldehyde 3-phosphate
YP_905786.1	catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase
YP_905787.1	converts protoheme IX and farnesyl diphosphate to heme O
YP_905788.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_905789.1	cytoplasmic protein; required for the transposition of the insertion element IS2606.
YP_905790.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_905791.1	cytoplasmic protein; involved in transcriptional mechanism
YP_905792.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; catalyzes the one electron reduction of certain quinones [catalytic activity: NADPH + quinone = NADP+ + semiquinone]
YP_905793.1	cytoplasmic protein
YP_905794.1	membrane protein; thought to be involved in active transport of antibiotic across the membrane (export): unidentified antibiotic resistance by an export mechanism. responsible for the translocation of the substrate across the membrane.
YP_905795.1	membrane protein; thought to be involved in active transport of antibiotic across the membrane (export): unidentified antibiotic resistance by an export mechanism. responsible for the translocation of the substrate across the membrane.
YP_905796.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; membrane protein; thought to be involved in active transport of antibiotic across the membrane (export): unidentified antibiotic resistance by an export mechanism. responsible for energy coupling to the transport system.
YP_905797.1	membrane protein
YP_905798.1	cytoplasmic protein; involved in transcriptional mechanism
YP_905799.1	cytoplasmic protein
YP_905800.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein
YP_905801.1	Detected in the extracellular matrix, the membrane and the cytoplasmic fractions by proteomics.; membrane protein; thought to be involved in active transport across the membrane. responsible for energy coupling to the transport system.
YP_905802.1	cytoplasmic protein; catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, l- selenocysteine, and L-selenocystine to produce L-alanine
YP_905803.1	cytoplasmic protein; function unknown, probably involved in cellular metabolism.
YP_905804.1	cytoplasmic protein
YP_905805.1	Detected in the cytoplasmic fraction by proteomics.; cytoplasmic protein; function unknown, but involvement in lipid degradation.
YP_905806.1	membrane protein
YP_905807.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_905808.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_905809.1	cytoplasmic protein; involved in electron transfer system for ribonucleotide reductase system NRDEF.
YP_905810.1	in Salmonella NrdI has a stimulatory effect on the ribonucleotide reductase activity of NrdH with NrdEF
YP_905811.1	Catalyzes the rate-limiting step in dNTP synthesis
YP_905812.1	cytoplasmic protein; involved in transcriptional mechanism
YP_905813.1	cytoplasmic protein; function unknown, involved in cellular metabolism.
YP_905814.1	cytoplasmic protein; involved in transcriptional mechanism.
YP_905815.1	cytoplasmic protein
YP_905816.1	B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE
YP_905817.1	Detected in the cytoplasmic and secreted fractions by 2D-LC-MS/MS.; cytoplasmic protein
YP_905818.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; alcohol dehydrogenase catalyzes the reversible oxidation of ethanol to acetaldehyde with the concomitant reduction of NAD: ethanol + NAD = acetaldehyde + NADH. belongs to the zinc-containing 'long-chain' alcohol dehydrogenases.
YP_905819.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; may be involved in active transport of FeIII- decitrate across the membrane (import)
YP_905820.1	Detected in the membrane fraction by proteomics.; cytoplasmic protein; cytochrome C oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. electrons originating in cytochrome C are transferred via the copper a center of subunit 2 and HemE a of subunit 1 to the bimetallic center formed by HemE A3 and copper B [catalytic activity: 4 ferrocytochrome C + O(2) = 2 H(2)O + 4 ferricytochrome C]
YP_905821.1	cytoplasmic protein; generates serine from phosphoserine [catalytic activity: phosphoserine + H(2)O = serine + phosphate]
YP_905822.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_905823.1	cytoplasmic protein; function unknown, probably involved in cellular metabolism.
YP_905824.1	membrane protein; function unknown, probably involved in cellular metabolism.
YP_905825.1	membrane protein; involved in hydrogen metabolism; FHL pathway.
YP_905826.1	membrane protein; involved in hydrogen metabolism.
YP_905827.1	membrane protein; possibly involved in hydrogen metabolism.
YP_905828.1	membrane protein; thought to be involved in active transport of undeterminated substrate (possibly iron) across the membrane. responsible for energy coupling to the transport system.
YP_905829.1	cytoplasmic protein
YP_905830.1	Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA
YP_905831.1	cytoplasmic protein
YP_905832.1	cytoplasmic protein
YP_905833.1	C-term extended due to frame shift mutation. This CDS now overlaps d/s CDS.; Detected in the secreted protein fraction by 2D-LC- MS/MS.; secreted protein
YP_905834.1	overlaps neigbouring CDS due to frame shift mutation that extends MUL_1902.; cytoplasmic protein
YP_905835.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_905836.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; function unknown, possibly involved in cellular metabolism.
YP_905837.1	membrane protein; function unknown; probably involved in lipid metabolism.
YP_905838.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_905839.1	cytoplasmic protein; function unknown, possible role in DNA replication, recombination, and repair.
YP_905840.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; function unknown. possibly involved in signal transduction mechanisms.
YP_905841.1	secreted protein; function unknown. thought to be involved in drug export.
YP_905842.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_905843.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_905844.1	cytoplasmic protein
YP_905845.1	membrane protein
YP_905846.1	Detected in the cytoplamic fraction by LCMSMS; cytoplasmic protein; function unknown, probably involved in cellular metabolism.
YP_905847.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; function unknown, possibly involved in cellular metabolism.
YP_905848.1	cytoplasmic protein
YP_905849.1	cytoplasmic protein
YP_905850.1	Detected in the cytoplasmic, the membrane and the extracellular matrix fractions by proteomics.; cytoplasmic protein; the electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. it transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase)
YP_905851.1	Detected in the cytoplasmic fraction by LC-MS/MS. Also detected in the extracellular matrix and the membrane fraction by proteomics.; cytoplasmic protein; the electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. it transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase)
YP_905852.1	cytoplasmic protein
YP_905853.1	membrane protein
YP_905854.1	cytoplasmic protein; catalyzes the removal of elemental sulfur from cysteine to produce alanine.
YP_905855.1	catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs
YP_905856.1	secreted protein
YP_905857.1	cytoplasmic protein
YP_905858.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_905859.1	this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB
YP_905860.1	cytoplasmic protein; possibly involved in a transcriptional mechanism
YP_905861.1	membrane protein
YP_905862.1	cytoplasmic protein
YP_905863.1	allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; some Mycoplasma proteins contain an N-terminal fusion to an unknown domain
YP_905864.1	allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA
YP_905865.1	catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis
YP_905866.1	allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA
YP_905867.1	membrane protein
YP_905868.1	membrane protein
YP_905869.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; function unknown function (putative membrane protein)
YP_905870.1	cytoplasmic protein
YP_905871.1	acetolactate synthase large subunit; catalyzes the formation of 2-acetolactate from pyruvate
YP_905872.1	with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit
YP_905873.1	catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis
YP_905874.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_905875.1	catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate
YP_905876.1	catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis
YP_905877.1	cytoplasmic protein; isomerizes HHDD (2-hydroxy-hept-2,4-diene-1,7- dioate) to ohed (2-oxo-hept-3-ene-1,7-dioate)
YP_905878.1	Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation
YP_905879.1	cytoplasmic protein
YP_905880.1	cytoplasmic protein
YP_905881.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_905882.1	cytoplasmic protein; required for the transposition of the insertion element IS2606.
YP_905883.1	membrane protein
YP_905884.1	cytoplasmic protein; could be involved in biotin biosynthesis (at the first step) [catalytic activity: 6-carboxyhexanoyl-CoA + L- alanine = 8-amino-7-oxononanoate + CoA + CO2]
YP_905885.1	cytoplasmic protein; involved in transcriptional mechanism.
YP_905886.1	dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate
YP_905887.1	catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D
YP_905888.1	Detected in the cytoplasmic fraction by LC-MS/MS. Also detected in the extracellular matrix and the membrane fraction by proteomics.; cytoplasmic protein; this protein belongs to the histone like family of prokaryotic DNA-binding proteins which are capable of wrapping DNA to stabilize it, and prevent its denaturation under extreme environmental conditions.
YP_905889.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; function unknown, hydrolytic enzyme. possibly involved in removal of damaged nucleotide.
YP_905890.1	catalyzes the reversible transfer of the terminal phosphate of ATP to form a long chain polyphosphate
YP_905891.1	membrane protein
YP_905892.1	catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate
YP_905893.1	D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli
YP_905894.1	membrane protein
YP_905895.1	catalyzes the formation of thiamine diphosphate from thiamine phosphate ant ATP
YP_905896.1	cytoplasmic protein
YP_905897.1	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
YP_905898.1	cytoplasmic protein; function unknown; probably involved in cellular metabolism.
YP_905899.1	required for 70S ribosome assembly
YP_905900.1	catalyzes branch migration in Holliday junction intermediates
YP_905901.1	Detected in the cytoplamic fraction by LC-MS/MS.; cytoplasmic protein; function unknown, probably involved in cellular metabolism.
YP_905902.1	cytoplasmic protein
YP_905903.1	cytoplasmic protein; function unknown, lipolytic enzyme involved in cellular metabolism.
YP_905904.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_905905.1	membrane protein
YP_905906.1	biotin-containing enzyme that catalyzes a two step carboxylation of pyruvate to oxaloacetate
YP_905907.1	Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA
YP_905908.1	secreted protein
YP_905909.1	membrane protein
YP_905910.1	cytoplasmic protein
YP_905911.1	membrane protein
YP_905912.1	activates fatty acids by binding to coenzyme A
YP_905913.1	cytoplasmic protein; responsible for the direct conversion of chorismate to p-hydroxybenzoate, the substrate used in the production of glycosylated p-hydroxybenzoic acid methyl esters and structurally related phenolphthiocerol glycolipids. in M. tuberculosis, this is the sole enzymatic source of p- hydroxybenzoic acid.
YP_905914.1	activates fatty acids by binding to coenzyme A
YP_905915.1	Also detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; polyketide synthase required for the elongation of p-HBAD derivatives to form p-hydroxybenzoate derivatives which are in turn converted to phenolphthiocerols by the ppsA-E locus. this is a key step in the production of phenolic glycolipids.
YP_905916.1	Also detected in the membrane fraction by proteomics.; secreted protein
YP_905917.1	secreted protein; involved in translocation of phthiocerol dimycocerosate (DIM) in the cell wall.
YP_905918.1	activates fatty acids by binding to coenzyme A
YP_905919.1	cytoplasmic protein; function unknown but orthologue in M. tuberculosis H37Rv has been shown to catalyze the transfer of a methyl group onto the lipid moiety of phthiotriol dimycocerosates to form DIM.
YP_905920.1	At least three isoforms were detected in the cytoplasmic extract. Also detected in the membrane fraction by proteomics.; membrane protein; catalyzes the elongation of N-fatty acyl-CoA with methylamalonyl-CoA (not malonyl-CoA) as the elongating agent to form mycocerosyl lipids.
YP_905921.1	required for PDIM synthesis; phthiocerol and phthiodiolone dimycocerosate esters are scaffolds used for virulence-enhancing lipids; proposed to catalyze diesterification of phthiocerol and phthiodolone with mycocerosate; functions in polyketide synthesis
YP_905922.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; probably involved in active transport of phthiocerol dimycocerosate (DIM) across the membrane (export) DrrA, DrrB and DrrC may act jointly to confer daunorubicin and doxorubicin resistance by an export mechanism. probably responsible for the translocation of the substrate across the membrane and localization of dim into the cell wall.
YP_905923.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; probably involved in active transport of phthiocerol dimycocerosate (DIM) across the membrane (export) DrrA, DrrB and DrrC may act jointly to confer daunorubicin and doxorubicin resistance by an export mechanism. probably responsible for the translocation of the substrate across the membrane and localization of DIM into the cell wall.
YP_905924.1	Detected in the membrane fraction by proteomics; membrane protein; probably involved in active transport of antibiotic and phthiocerol dimycocerosate (DIM) across the membrane (export) DrrA, DrrB and DrrC may act jointly to confer daunorubicin and doxorubicin resistance by an export mechanism. responsible for energy coupling to the transport system.
YP_905925.1	Three isoforms of the protein were detected in the cytoplasm by proteomics. Also detected in the membrane fraction by proteomics.; cytoplasmic protein; involved in phenolpthiocerol and phthiocerol dimycocerosate (DIM) biosynthesis: extension with Malony CoA (partial reduction, decarboxylation)
YP_905926.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; involved in phenolpthiocerol and phthiocerol dimycocerosate (DIM) biosynthesis: extension with methylmalony CoA (partial reduction)
YP_905927.1	Detected in the cytoplasmic fraction by proteomics.; cytoplasmic protein; involved in phenolpthiocerol and phthiocerol dimycocerosate (DIM) biosynthesis: extension with Malony CoA (complete reduction)
YP_905928.1	Detected in the membrane fraction by proteomics (2D- LC-MS/MS); membrane protein; involved in phenolpthiocerol and phthiocerol dimycocerosate (DIM) biosynthesis: extension with Malony CoA (partial reduction)
YP_905929.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS. Also detected in the membrane fraction by proteomics (LC-MS/MS); cytoplasmic protein; involved in phenolpthiocerol and phthiocerol dimycocerosate (DIM) biosynthesis: extension of C18 with Malony CoA (partial reduction)
YP_905930.1	activates fatty acids by binding to coenzyme A
YP_905931.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_905932.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_905933.1	cytoplasmic protein; function unknown however in M. tuberculosis H37Rv TesA interacts with the PpsE protein. PpsE is part of the phenolphthiocerol synthase PKS cluster.
YP_905934.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_905935.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_905936.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; function unknown, possibly involved in cell division and chromosome partitioning.
YP_905937.1	cytoplasmic protein
YP_905938.1	cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity
YP_905939.1	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases
YP_905940.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; function unknown.  contains N-term OsmC-like protein domain and C-term AcyP, acylphosphatases domain.
YP_905941.1	membrane protein; plays an important role in chromosome structure and partitioning. essential for chromosome partition.
YP_905942.1	membrane protein; probably involved in the reception and insertion of a subset of proteins at the membrane: possibly membrane receptor for Ffh.
YP_905943.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; in nitrogen-limiting conditions, when the ratio of Gln to 2-ketoglutarate decreases, P-II is uridylylated to P-II-UMP by GlnD. P-II-UMP allows the deadenylylation of glutamine synthetase (gs), thus activating the enzyme. converserly, in nitrogen excess P-II is deuridylated and promotes the adenylation of gs. P-II indirectly controls the transcription of the gs gene. P-II prevents NR-II catalyzed conversion of NR-I to NR-I-phosphate, the transcriptional activator of GlnA. when P-II is uridylylated to P-II-UMP, these events are reversed.
YP_905944.1	cytoplasmic protein
YP_905945.1	cytoplasmic protein
YP_905946.1	Also detected in the cytoplasmic fraction by 2D-LC- MS/MS; cytoplasmic protein; necessary for efficient export of extra-cytoplasmic proteins. binds to the signal sequence when it emerges from the ribosomes.
YP_905947.1	cytoplasmic protein
YP_905948.1	membrane protein; involved in signal transduction (via phosphorylation) thought to be involved in cell division/differentiation [catalytic activity: ATP + a protein = ADP + a phosphoprotein]
YP_905949.1	cytoplasmic protein; hydrolizes a specific D-amino acid.
YP_905950.1	cytoplasmic protein; thought to be involved in transcriptional mechanism.
YP_905951.1	secreted protein; involved in peptidoglycan synthesis (at final stages) hydrolyzes the bound D-alanyl-D-alanine [catalytic activity: D-alanyl-D-alanine + H(2)O = 2 D- alanine]
YP_905952.1	cytoplasmic protein
YP_905953.1	binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity
YP_905954.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein
YP_905955.1	Essential for efficient processing of 16S rRNA
YP_905956.1	methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA
YP_905957.1	secreted protein
YP_905958.1	this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site
YP_905959.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; cleavage of N-terminal leader sequences from secreted protein precursors.
YP_905960.1	RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids
YP_905961.1	cytoplasmic protein
YP_905962.1	cytoplasmic protein
YP_905963.1	membrane protein; function unknown, possibly involved in galactose metabolism.
YP_905964.1	involved in the production or activity of formate dehydrogenase-H which is active when nitrate is not present during anaerobic growth
YP_905965.1	cytoplasmic protein
YP_905966.1	membrane protein
YP_905967.1	Also detected in the extracellular matrix by proteomics.; cytoplasmic protein; thought to be involved in intracellular removal of iron from iron-mycobactin complex. mycobactin is an iron- chelating compound involved in the transport of iron from the bacterial environment into the cell cytoplasm.
YP_905968.1	site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs
YP_905969.1	one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit
YP_905970.1	EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu
YP_905971.1	catalyzes the hydrolysis of a monocarboxylic acid amid to form a monocarboxylate and ammonia
YP_905972.1	membrane protein; involved in transcriptional mechanism.
YP_905973.1	membrane protein
YP_905974.1	membrane protein
YP_905975.1	cytoplasmic protein; involved in transcriptional mechanism
YP_905976.1	Also detected in the membrane fraction by proteomics (2D-LC-MS/MS); cytoplasmic protein; uridine monophosphate kinase [catalytic activity: ATP + ump = ADP + UDP]
YP_905977.1	Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs
YP_905978.1	membrane protein; involved in the phospholipid biosynthesis [catalytic activity: CTP + phosphatidate = pyrophosphate + CDP-diacylglycerol]
YP_905979.1	23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance
YP_905980.1	secreted protein; not really known. despite a weak homology to thioredoxin this cannot serve as a substrate for thioredoxin reductase. furthermore it has no disulfide reducing activity.
YP_905981.1	membrane protein; function unknown, possibly involved in transport of mercury across the membrane.
YP_905982.1	cytoplasmic protein
YP_905983.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_905984.1	membrane protein; may be involved in cytochrome-C biogenesis.
YP_905985.1	catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate
YP_905986.1	membrane protein
YP_905987.1	catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis
YP_905988.1	cytoplasmic protein
YP_905989.1	secreted protein; function unknown, possibly involved in cell wall biosynthesis.
YP_905990.1	cytoplasmic protein
YP_905991.1	cytoplasmic protein; removes the amino-terminal methionine from nascent proteins [catalytic activity: L-methionylpeptide + H(2)O = L-methionine + peptide]
YP_905992.1	membrane protein
YP_905993.1	cytoplasmic protein; function unknown, probably involved in cellular metabolism.
YP_905994.1	membrane protein
YP_905995.1	membrane protein
YP_905996.1	membrane protein
YP_905997.1	membrane protein
YP_905998.1	cytoplasmic protein
YP_906000.1	cytoplasmic protein
YP_906001.2	malate dehydrogenase; catalyzes the oxidation of malate to oxaloacetate
YP_906002.1	cytoplasmic protein; function unknown, predicted acyltransferase activity
YP_906003.1	cytoplasmic protein; function unknown, possibly introduces a magnesium ion into specific substrate/compound.
YP_906004.1	catalyzes the formation of adenosylcob(III)yrinic acid a,c-diamide from cob(I)yrinic acid a,c-diamide
YP_906005.1	responsible for the amidation of carboxylic groups at position A and C of cobyrinic acid or hydrogenobrynic acid
YP_906006.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; involved in the biosynthesis of siroheme and cobalamin [catalytic activity: 2 S-adenosyl-L-methionine + uroporphyrin III = 2 S-adenosyl-L-homocysteine + sirohydrochlorin] SAM-dependent methyl transferase that methylates uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. it catalyzes also the conversion of precorrin-2 into siroheme (consisting of an oxidation and fe(2+) chelation)
YP_906007.1	membrane protein; thought to be involved in transport of undeterminated substrate (possibly drug) across the membrane (export): so responsible for the translocation of the substrate across the membrane.
YP_906008.1	catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro)
YP_906009.1	cytoplasmic protein
YP_906010.1	membrane protein
YP_906011.1	in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins
YP_906012.1	modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination
YP_906013.1	cytoplasmic protein
YP_906014.1	Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
YP_906015.1	associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock
YP_906016.1	cytoplasmic protein
YP_906017.1	membrane protein; function unknown, induction by DNA damage.
YP_906018.1	membrane protein; involved in active transport of SN-glycerol-3- phosphate across the membrane (import) responsible for the translocation of the substrate across the membrane.
YP_906019.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_906020.1	membrane protein
YP_906021.1	cytoplasmic protein
YP_906022.1	cytoplasmic protein; function unknown, probably involved in cellular metabolism.
YP_906023.1	secreted protein
YP_906024.1	cytoplasmic protein
YP_906025.1	secreted protein
YP_906026.1	secreted protein
YP_906027.1	cytoplasmic protein
YP_906028.1	cytoplasmic protein; phosphopantetheinyl transferase. secondary metabolites biosynthesis, transport, and catabolism. Sfp- type phosphopantetheinyl transferase
YP_906029.1	catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs
YP_906030.1	membrane protein; possibly catalyzes the transfer of a great variety of lipids between membranes.
YP_906031.1	membrane protein; function unknown, but involved in lipid degradation.
YP_906032.1	cytoplasmic protein; involved in transcriptional mechanism.
YP_906033.1	catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities
YP_906034.1	primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence
YP_906035.1	secreted protein
YP_906036.1	cytoplasmic protein
YP_906037.1	Detected in the membrane fraction by proteomics (2D- LC-MS/MS) Also detected in the cytoplamic fraction by LC- MS/MS and in the extracellular matrix fraction by proteomics.; cytoplasmic protein; involved in mRNA degradation. hydrolyses single- stranded polyribonucleotides processively in the 3' to 5' direction. involved in the RNA degradosome, a multi-enzyme complex important in RNA processing and messenger RNA degradation [catalytic activity: RNA(n+1) + phosphate = RNA(N) + a nucleoside diphosphate]
YP_906038.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_906039.1	secreted protein
YP_906040.1	Also detected in the cytoplasmic and membrane fractions by proteomics.; secreted protein; may play a role in cell wall synthesis as L-alanine is an important constituent of the peptidoglycan layer [catalytic activity: L-alanine + H(2)O + NAD(+) = pyruvate + NH(3) + NADH]
YP_906041.1	cytoplasmic protein; involved in transcriptional mechanism.
YP_906042.1	Also detected in the membrane fraction by proteomics.; cytoplasmic protein
YP_906043.1	cytoplasmic protein
YP_906044.1	cytoplasmic protein; function unknown, probably involved in cellular metabolism.
YP_906045.1	cytoplasmic protein
YP_906046.1	cytoplasmic protein; function unknown, probably involved in cellular metabolism.
YP_906047.1	cytoplasmic protein
YP_906048.1	catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis
YP_906049.1	secreted protein
YP_906050.1	cytoplasmic protein
YP_906051.1	PPE44; membrane protein; function unknown. may be involved in virulence
YP_906052.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_906053.1	Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis
YP_906054.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_906055.1	cytoplasmic protein; function unknown, but supposed involvement in lipid degradation.
YP_906056.1	Detected in the secreted fraction by proteomics.; secreted protein; function unknown, probably involved in cellular metabolism.
YP_906057.1	ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived
YP_906058.1	cytoplasmic protein; essential step for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dump to dTMP [catalytic activity: 5,6,7,8- tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + NADPH]
YP_906059.1	cytoplasmic protein
YP_906060.1	flavin dependent thymidylate synthase; ThyX; thymidylate synthase complementing protein; catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate; the enzyme from Mycobacterium tuberculosis forms homotetramers; uses FAD as a cofactor
YP_906061.1	catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis
YP_906062.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_906063.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_906064.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_906065.1	cytoplasmic protein; acts as a global negative controlling element, employing fe(2+) as a cofactor to bind the operator of the repressed genes. seems to regulate transcription of KatG gene.
YP_906066.1	Also detected in the secreted protein fraction by 2D-LC-MS/MS.; cytoplasmic protein; multifunctional enzyme, exhibiting both a catalase, a broad-spectrum peroxidase, and a peroxynitritase activities. may play a role in the intracellular survival of mycobacteria within macrophages; protection against reactive oxygen and nitrogen intermediates produced by phagocytic cells. seems regulated by SigB [catalytic activity: 2 H(2)O(2) = O(2) + 2 H(2)O]
YP_906067.1	membrane protein; high-affinity uptake of glycine betaine. supposed responsible for the translocation of the substrate across the membrane.
YP_906068.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_906069.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_906070.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein
YP_906071.1	cytoplasmic protein; function unknown, probably involved in cellular metabolism
YP_906072.1	membrane protein; involved in signal transduction (via phosphorylation) thought to be involved in membrane transport. phosphorylates the peptide substrate myelin basic protein (MBP) at serine and threonine residues [catalytic activity: ATP + a protein = ADP + a phosphoprotein]
YP_906073.1	cytoplasmic protein; function unknown.
YP_906074.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS. Also detected in the membrane fraction by proteomics (2D-LC-MS/MS); cytoplasmic protein
YP_906075.1	Also detected in the extracellular matrix and membrane fraction by proteomics.; cytoplasmic protein
YP_906076.1	secreted protein; function unknown.  secreted protein.
YP_906077.1	cytoplasmic protein; thought to be involved in fatty acid degradation. FadB and FadA are the alpha and BetA subunits of the multifunctional enzyme complex of the fatty acid degradation cycle.
YP_906078.1	membrane protein; function unknown, unknown, contains a C-term cellobiohydrolase a (1,4-beta-cellobiosidase a) domain and a N-term cellulose-binding domain (CBD) domain. the CBD is found either at the N-term or at the C-term of endoglucanases, cellobiohydrolases (exoglucanases), or xylanases
YP_906079.1	cytoplasmic protein; could be involved in the catabolism of catechol to succinate- and acetyl-CoA in the beta-ketoadipate pathway (at the third step) [catalytic activity: 2,5-dihydro-5- oxofuran-2-acetate = 3,4-dihydro-5-oxofuran-2-acetate]
YP_906080.1	E3 component of alpha keto acid dehydrogenase complexes LpdC; forms a homodimer; binds one molecule of FAD monomer; catalyzes NAD+-dependent oxidation of dihydrolipoyl cofactors that are covalently linked to the E2 component
YP_906081.1	membrane protein
YP_906082.1	cytoplasmic protein
YP_906083.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_906084.1	cytoplasmic protein; required for the transposition of the insertion element IS2606.
YP_906085.1	secreted protein; function unknown.  possible secreted protein.
YP_906086.1	cytoplasmic protein
YP_906087.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein
YP_906088.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_906089.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_906090.1	Also detected in the extracellular matrix by proteomics, and in the membrane fraction.; cytoplasmic protein; function unknown. may be involved in a chaperoning process.
YP_906091.1	cytoplasmic protein; involved in the biosynthesis of tetrahydrofolate (at the first step) [catalytic activity: GTP + 2 H(2)O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3- trihydroxypropyl)DiHYD ro pteridine triphosphate]
YP_906092.1	Detected in the membrane fraction by proteomics (LC- MS/MS) Also detected in the cytoplasmic and extracellular matrix fractions by proteomics.; membrane protein
YP_906093.1	membrane protein; function unknown.  possibly involved in signal transduction mechanisms.
YP_906094.1	cytoplasmic protein
YP_906095.1	cytoplasmic protein; the sigma factor is an initiation factor that promotes attachment of the RNA polymerase to specific initiation sites and then is released.
YP_906096.1	membrane protein; function unknown.  possibly involved in lipid metabolism.
YP_906097.1	cytoplasmic protein
YP_906099.1	secreted protein
YP_906100.1	membrane protein
YP_906101.1	secreted protein
YP_906102.1	membrane protein
YP_906103.1	cytoplasmic protein
YP_906104.1	membrane protein
YP_906105.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_906106.1	membrane protein; thought to be involved in active transport of sugar across the membrane (import) responsible for energy coupling to the transport system.
YP_906107.1	membrane protein
YP_906108.1	membrane protein; thought to be involved in active transport of sugar across the membrane (import) responsible for the translocation of the substrate across the membrane.
YP_906109.1	cytoplasmic protein; converts amides such as nicotinamide to corresponding acid.
YP_906110.1	membrane protein
YP_906111.1	membrane protein; function unknown, in general gluconate kinase catalyzes the phosphoryl transfer from ATP to gluconate. the resulting product gluconate-6-phosphate is an important precursor of gluconate metabolism.
YP_906112.1	cytoplasmic protein; converts unknown esters to corresponding free acid and alcohol
YP_906113.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_906114.1	cytoplasmic protein
YP_906115.1	membrane protein
YP_906116.1	Also detected in the cytoplasmic fraction by 2D-LC- MS/MS.; membrane protein
YP_906117.1	cytoplasmic protein; required for mycoketide synthesis.
YP_906118.1	cytoplasmic protein
YP_906119.1	cytoplasmic protein
YP_906120.1	This gene in two parts compared with MTB orthologue. Potential pseudogene but given same arrangement in M. marinum then this possibility seems less likely.; cytoplasmic protein; transfers mannose from GDP-mannose to all endogenous polyprenol-phosphates in mycobacterium tuberculosis
YP_906121.1	cytoplasmic protein; transfers mannose from GDP-mannose to all endogenous polyprenol-phosphates in mycobacterium tuberculosis
YP_906122.1	domain identity with predicted metal-dependent hydrolases with the TIM-barrel folds
YP_906123.1	F exclusion of bacteriophage T7; overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7; interacts with the F plasmid-encoded PifA protein; inner membrane protein
YP_906124.1	cytoplasmic protein; domain identity with dienelactone hydrolases
YP_906125.1	membrane protein
YP_906126.1	membrane protein
YP_906127.1	membrane protein; function unknown.  domain identity to ThiJ-like intracellular proteases/amidases
YP_906128.1	cytoplasmic protein
YP_906129.1	with CobST catalyzes the formation of cobyrinic acid a,c-diamide from hydrogenobyrinic acid a,c-diamide in an ATP-dependent manner; involved in porphyrin and chlorophyll metabolism; vitamin B12 metabolism
YP_906130.1	cytoplasmic protein
YP_906131.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; membrane protein
YP_906132.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_906133.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_906134.1	cytoplasmic protein; cellular metabolism
YP_906135.1	cytoplasmic protein
YP_906136.1	cytoplasmic protein; function unknown.  contains adenylate cyclase domain
YP_906138.1	catalyzes the interconversion of precorrin-8X and hydrogenobyrinate
YP_906139.1	detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; involved in cobalamin biosynthesis
YP_906140.1	cytoplasmic protein
YP_906141.1	membrane protein
YP_906142.1	Also detected in the cytoplasmic fraction by proteomics; membrane protein; hydrolyses beta-lactams to generate corresponding beta-amino acid [catalytic activity: a beta-lactam + H(2)O = a substituted beta-amino acid]
YP_906143.1	Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription
YP_906144.1	CobK/CbiJ; there are 2 pathways for cobalamin (vitamin B12) production, one aerobic (ex. P. denitrificans), the other anaerobic (ex. S. typhimurium); the CobK/CbiJ perform similar reactions in both; the anaerobic pathway includes the use of a chelated cobalt ion in order for ring contraction to occur; CobK thus converts precorrin 6 into dihydro-precorrin 6 while CbiJ converts cobalt-precorrin 6 into cobalt-deihydro-precorrin 6
YP_906145.1	cytoplasmic protein; involved in cobalamin biosynthesis
YP_906146.1	cytoplasmic protein
YP_906147.1	cytoplasmic protein
YP_906148.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS. Also detected in the membrane fraction by proteomics (LC-MS/MS); cytoplasmic protein
YP_906149.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_906150.1	membrane protein
YP_906151.1	cytoplasmic protein
YP_906152.1	cytoplasmic protein; transposition of an insertion sequence
YP_906153.1	secreted protein
YP_906154.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; membrane protein
YP_906155.1	membrane protein
YP_906156.1	cytoplasmic protein
YP_906157.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein
YP_906158.1	cytoplasmic protein
YP_906159.1	cytoplasmic protein
YP_906160.1	cytoplasmic protein
YP_906161.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein
YP_906162.1	cytoplasmic protein
YP_906163.1	Detected in the cytoplamic fraction by 2D-LC- MS/MS.; cytoplasmic protein; hydrolysis of peptide bonds
YP_906164.1	cytoplasmic protein; involved in DNA metabolism
YP_906165.1	Detected in the membrane fraction by proteomics (2D- LC-MS/MS); membrane protein
YP_906166.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; DNA helicase activity.
YP_906167.1	membrane protein; involved in proteins export: required for correct localization of precursor proteins bearing signal peptides with the twin arginine conserved motif S/T-R-R-X-F-L-K. this sec-independent pathway is termed tat for twin- arginine translocation system.
YP_906168.1	TatA; similar to TatE that is found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes
YP_906169.1	cytoplasmic protein
YP_906170.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; contains domain homology to transcriptional regulators
YP_906171.1	cytoplasmic protein
YP_906172.1	Detected in the cytoplasmic, membrane and secreted protein fractions by proteomics.; cytoplasmic protein; protein degradation
YP_906173.1	Detected in the cytoplasmic, the membrane and the secreted fractions by proteomics.; cytoplasmic protein; protein degradation
YP_906174.1	Detected in the cytoplasmic ans secreted fractions by 2D-LC-MS/MS.; cytoplasmic protein
YP_906175.1	Also detected in the membrane fraction by proteomics (2D-LC-MS/MS); cytoplasmic protein
YP_906176.1	Detected in the cytoplasmic fraction by proteomics.; cytoplasmic protein
YP_906177.1	membrane protein
YP_906178.1	cytoplasmic protein
YP_906179.1	cytoplasmic protein
YP_906180.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_906181.1	cytoplasmic protein
YP_906182.1	cytoplasmic protein; involved in transfer of methyl group (from S- adenosyl-L-methionine to a substrate)
YP_906183.1	cytoplasmic protein; has significant domain identity to RecB family exonucleases
YP_906184.1	cytoplasmic protein
YP_906185.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_906186.1	cytoplasmic protein; required for the transposition of the insertion element IS2606
YP_906187.1	cytoplasmic protein; required for the transposition of the insertion element IS2606.
YP_906188.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_906189.1	long form of enzyme; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms active dimers and inactive hexamers which is dependent on concentration of substrates and inhibitors
YP_906190.1	catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribolsyl)-ATP in histidine biosynthesis
YP_906191.1	membrane protein
YP_906192.1	cytoplasmic protein
YP_906193.1	membrane protein; function unknown, probably involved in cellular metabolism.
YP_906194.1	cytoplasmic protein
YP_906195.1	catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA
YP_906196.1	cytoplasmic protein; involved in 4-aminobutyrate (GabA) degradation pathway [catalytic activity: succinate semialdehyde + NAD(P)(+) + H(2)O = succinate + NAD(P)H]
YP_906197.1	cytoplasmic protein; may help control the pool of 3'-phosphoadenoside 5'- phosphosulfate, or its use in sulfite synthesis (by similarity)
YP_906198.1	cytoplasmic protein
YP_906199.1	Detected in the cytoplasmic and secreted fractions by 2D-LC-MS/MS.; cytoplasmic protein
YP_906200.1	cytoplasmic protein
YP_906201.1	BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell
YP_906202.1	cytoplasmic protein
YP_906203.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_906204.1	cytoplasmic protein
YP_906205.1	catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors
YP_906206.1	cytoplasmic protein
YP_906207.1	Also detected in the extracellular matrix by proteomics.; cytoplasmic protein; function unknown but contains bacterial/archael phosphatidylethanolamine-binding (PEBP) domain
YP_906208.1	Also detected in the membrane fraction by proteomics (2D-LC-MS/MS); cytoplasmic protein; function unknown - but has domain identity with cetylornithine deacetylase/succinyl-diaminopimelate desuccinylase and related deacylases [amino acid transport and metabolism]
YP_906209.1	cytoplasmic protein
YP_906210.1	cytoplasmic protein; orthologue in M. tuberculosis H37Rv has been shown to catalyze the transfer of a methyl group onto the lipid moiety of phthiotriol dimycocerosates to form DIM.
YP_906211.1	cytoplasmic protein
YP_906212.1	cytoplasmic protein; thought to be involved in the biogenesis of the hydroxyphenyloxazoline-containing siderophore mycobactins.
YP_906213.1	membrane protein
YP_906214.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_906215.1	Detected in the membrane fraction by proteomics.; secreted protein
YP_906216.1	cytoplasmic protein
YP_906218.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_906219.1	cytoplasmic protein
YP_906220.1	membrane protein
YP_906221.1	membrane protein
YP_906222.1	cytoplasmic protein
YP_906223.1	cytoplasmic protein
YP_906224.1	PE26; membrane protein
YP_906225.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS. Also detected in the membrane fraction by proteomics.; cytoplasmic protein
YP_906226.1	membrane protein
YP_906227.1	membrane protein; ATPase; possibly catalyzes the transport of undeterminated substrate with hydrolysis of ATP [catalytic activity: ATP + H(2)O + undeterminated substrate(in) = ADP + phosphate + undeterminated substrate(out)]
YP_906228.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_906229.1	cytoplasmic protein; required for the transposition of the insertion element IS2606
YP_906230.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_906231.1	binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation
YP_906232.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; involved in growth (principally during log phase cells) thought to be involved in active transport of septation component across the membrane. responsible for the translocation of the substrate across the membrane. coded for in an operon essential for ce
YP_906233.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; involved in growth. thought to be involved in active transport of septation component across the membrane. responsible for energy coupling to the transport system. coded for in an operon essential for cell division.
YP_906234.1	membrane protein; function unknown: predicted solute binding protein
YP_906235.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; function unknown but contains mechanosensitive (ms) ion channel forming domain with a possible role in cell envelope biogenesis.
YP_906236.1	recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2; in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism; this protein is similar to release factor 1
YP_906237.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS. Also detected in the membrane fraction by proteomics.; cytoplasmic protein; generates oxidized ferredoxin from ferredoxin [catalytic activity: reduced ferredoxin + NADP(+) = oxidized ferredoxin + NADPH]
YP_906238.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_906239.1	cytoplasmic protein
YP_906240.1	cytoplasmic protein
YP_906241.1	Also detected in the extracellular matrix and the membrane fraction by proteomics.; cytoplasmic protein
YP_906242.1	cytoplasmic protein
YP_906243.1	cytoplasmic protein
YP_906244.1	cytoplasmic protein
YP_906245.1	membrane protein; sensor part of the two component regulatory system DevR/DevS. thought to control HspX|Acr expression.
YP_906246.1	cytoplasmic protein; regulator part of the two component regulatory system DevR/DevS. controls HspX|Acr expression.
YP_906247.1	membrane protein; may play a role in the adaptation to hypoxia, participating in the phosphorelay in the two component regulatory system DevR/DevS
YP_906248.1	cytoplasmic protein; required for the transposition of the insertion element IS2606
YP_906249.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_906250.1	Detected in the membrane fraction by proteomics (2D- LC-MS/MS); membrane protein
YP_906251.1	PPE51; membrane protein
YP_906252.1	membrane protein
YP_906253.1	cytoplasmic protein; function unknown, involved in cellular metabolism.
YP_906254.1	cytoplasmic protein; function unknown, but involved in lipid degradation.
YP_906255.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; function unknown, but involved in lipid degradation.
YP_906256.1	catalyzes the formation of 2-acetolactate from pyruvate in stationary phase
YP_906257.1	cytoplasmic protein; function unknown, possible role secondary metabolite biosynthesis
YP_906258.1	catalyzes the formation of pyruvate and acetaldehyde from 4-hydroxy-2-ketovaleric acid; involved in the degradation of phenylpropionate
YP_906259.2	catalyzes the formation of acetyl-CoA from acetalaldehyde
YP_906260.1	Potential extended N-term caused by an u/s DNA deletion and point mutation that has created a fusion of MON6244 and MON2437; membrane protein
YP_906261.1	cytoplasmic protein; function unknown, probably involved in cellular metabolism.
YP_906262.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; involved in lipid degradation [catalytic activity: NADPH + quinone = NADP(+) + semiquinone]
YP_906263.1	PPE28; membrane protein
YP_906264.1	cytoplasmic protein; required for the transposition of the insertion element IS2606.
YP_906265.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_906266.1	cytoplasmic protein
YP_906267.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein
YP_906268.1	cytoplasmic protein
YP_906269.1	cytoplasmic protein; involved in transcriptional mechanism.
YP_906270.1	cytoplasmic protein
YP_906271.1	cytoplasmic protein
YP_906272.1	cytoplasmic protein
YP_906273.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_906274.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS; cytoplasmic protein
YP_906275.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_906276.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_906277.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_906278.1	Catalyzes the transfer of electrons from NADH to quinone
YP_906279.1	The point of entry for the majority of electrons that traverse the respiratory chain eventually resulting in the reduction of oxygen
YP_906280.1	Catalyzes the transfer of electrons from NADH to quinone
YP_906281.1	Catalyzes the transfer of electrons from NADH to quinone
YP_906282.1	Catalyzes the transfer of electrons from NADH to quinone
YP_906283.1	Detected in the membrane fraction by proteomics (2D- LC-MS/MS); involved in aerobic|anaerobic respiration [catalytic activity: NADH + ubiquinone = NAD(+) + ubiquinol]
YP_906284.1	Catalyzes the transfer of electrons from NADH to quinone
YP_906285.1	Catalyzes the transfer of electrons from NADH to quinone
YP_906286.1	Catalyzes the transfer of electrons from NADH to quinone
YP_906287.1	Catalyzes the transfer of electrons from NADH to quinone
YP_906288.1	Catalyzes the transfer of electrons from NADH to quinone
YP_906289.1	Catalyzes the transfer of electrons from NADH to ubiquinone
YP_906290.1	Catalyzes the transfer of electrons from NADH to quinone
YP_906291.1	Catalyzes the transfer of electrons from NADH to quinone
YP_906292.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_906293.1	membrane protein
YP_906294.1	membrane protein
YP_906295.1	cytoplasmic protein; involved in transcriptional mechanism; regulates methanol dehydrogenase.
YP_906296.1	cytoplasmic protein
YP_906297.1	cytoplasmic protein; function unknown, possibly involved in cellular metabolism.
YP_906298.1	cytoplasmic protein; involved in transcriptional mechanism.
YP_906299.1	cytoplasmic protein
YP_906300.1	cytoplasmic protein
YP_906301.1	PE_PGRS9; membrane protein
YP_906302.1	cytoplasmic protein; function unknown, probably involved in cellular metabolism.
YP_906303.1	cytoplasmic protein; may catalyze the oxidative deamination: oxidize on primary amines, and perhaps on secondary and tertiary amines [catalytic activity: RCH(2)NH(2) + H(2)O + O(2) = RchO + NH(3) + H(2)O(2)] may have important function in metabolism. supposed involved
YP_906304.1	cytoplasmic protein; supposed involved in detoxification reactions.
YP_906305.1	cytoplasmic protein; possibly catalyzes the oxidative deamination: oxidize on primary amines, and perhaps on secondary and tertiary amines [catalytic activity: RCH(2)NH(2) + H(2)O + O(2) = RchO + NH(3) + H(2)O(2)]
YP_906306.1	cytoplasmic protein
YP_906307.1	cytoplasmic protein
YP_906308.1	cytoplasmic protein
YP_906309.1	cytoplasmic protein
YP_906310.1	cytoplasmic protein
YP_906311.1	catalyzes the formation of citrate from acetyl-CoA and oxaloacetate
YP_906312.1	Detected in the membrane fraction by proteomics (LC- MS/MS); cytoplasmic protein
YP_906313.1	cytoplasmic protein; involved in transcriptional mechanism
YP_906314.1	cytoplasmic protein
YP_906315.1	cytoplasmic protein
YP_906316.1	cytoplasmic protein; thought to play an important role in the mineralization of sulfates [catalytic activity: a phenol sulfate + H2O = a phenol + sulfate]
YP_906317.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; function unknown, possible role in posttranslational modification, protein turnover, chaperonefunctions
YP_906318.1	cytoplasmic protein
YP_906319.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_906320.1	secreted protein
YP_906321.1	cytoplasmic protein
YP_906322.1	cytoplasmic protein
YP_906323.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein
YP_906324.1	thought to be involved in active transport across the membrane. responsible for energy coupling to the transport system.
YP_906325.1	cytoplasmic protein; involved in transcriptional mechanism.
YP_906326.1	cytoplasmic protein; involved in nucleotide excision repair. has both ATPase and helicase activities. unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single- stranded region is present. involved in the postincision events of nucleotide excision repair and methyl-directed mismatch repair.
YP_906327.1	cytoplasmic protein
YP_906328.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_906329.1	cytoplasmic protein; required for the transposition of the insertion element IS2606.
YP_906330.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_906331.1	membrane protein
YP_906332.1	can catalyze hydrolysis of broad range of dinucleotide pyrophosphates but prefers reduced form of NADH; requires divalent metal ions such as magnesium and manganese and produces two mononucleoside 5'-phosphates
YP_906333.1	membrane protein; thought to be involved in cation transport across the membrane.
YP_906334.1	Detected in the membrane fraction by proteomics.; membrane protein; has both ATPase and helicase activities
YP_906335.1	membrane protein; has both ATPase and helicase activities
YP_906336.1	membrane protein
YP_906337.1	cytoplasmic protein
YP_906338.1	function unknown, presumed lipolytic enzyme involved in cellular metabolism.
YP_906339.1	cytoplasmic protein; causes methylation of DNA.
YP_906340.1	cytoplasmic protein
YP_906341.1	The proteins in this cluster have high sequence similarity to MoeB and are possibly involved in the synthesis of molybdopterin, but there has been no biochemical or physiological characterization. There is also no genetic linkage to other molybdopterin cofactor synthesis proteins. These proteins are similar to a Pseudomonas stutzeri protein which is essential to pyridine-2,6-bis(thiocarboxylic acid) synthesis that possibly activates a substrate by adenylation
YP_906343.1	cytoplasmic protein; involved in transcriptional mechanism.
YP_906344.1	Detected in the cytoplamic fraction by LC-MS/MS. Also detected in the membrane fraction by proteomics (2D- LC-MS/MS); cytoplasmic protein
YP_906345.1	membrane protein
YP_906346.1	cytoplasmic protein
YP_906347.1	cytoplasmic protein; has a helix-destabilizing activity
YP_906348.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_906349.1	cytoplasmic protein; possibly involved in control of chromosome partitioning.
YP_906350.1	forms a homodimer in Mycobacterium tuberculosis; belongs to the dPGM superfamily
YP_906351.1	cytoplasmic protein; could be involved in enterobactin biosynthesis. enterobactin is an iron-chelating compound involved in transporting iron from the bacterial environment into the cell cytoplasm. could be also involved in 2,3- dihydroxybenzoate or enterochelin or menaquinone biosynthesis [catalytic activity: chorismate = isochorismate]
YP_906352.1	cytoplasmic protein; function unknown, involved in cellular metabolism.
YP_906353.1	membrane protein
YP_906354.1	cytoplasmic protein
YP_906355.1	cytoplasmic protein; involved in transcriptional mechanism.
YP_906356.1	membrane protein; sensor part of a two component regulatory system.
YP_906357.1	cytoplasmic protein
YP_906358.1	cytoplasmic protein; binds sigma factor and inhibits it. probably involved in survival following heat shock and oxidative stress.
YP_906359.1	Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor is involved in heat shock and oxidative stress response
YP_906360.1	Detected in the cytoplamic fraction by LC-MS/MS. Also detected in the membrane fraction by proteomics (2D- LC-MS/MS); cytoplasmic protein; function unknown, probably involved in cellular metabolism.
YP_906361.1	membrane protein
YP_906362.1	cytoplasmic protein
YP_906363.1	cytoplasmic protein
YP_906364.1	cytoplasmic protein
YP_906365.1	cytoplasmic protein
YP_906367.1	membrane protein
YP_906368.1	membrane protein; may be involved in regulation
YP_906369.1	cytoplasmic protein
YP_906371.1	cytoplasmic protein; thought to be involved in fatty acid degradation. FadB and FadA are the alpha and BetA subunits of the multifunctional enzyme complex of the fatty acid degradation cycle [catalytic activity: (S)-3- hydroxybutanoyl-CoA + NADP+ = 3-acetoacetyl-CoA + NADPH]
YP_906372.1	cytoplasmic protein
YP_906373.1	catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis
YP_906374.1	cytoplasmic protein
YP_906375.1	cytoplasmic protein; function unknown. could be involved in regulatory mechanism.
YP_906376.1	cytoplasmic protein; function unknown, but involved in lipid metabolism [catalytic activity: 2 acetyl-CoA = CoA + acetoacetyl- CoA]
YP_906377.1	cytoplasmic protein; thought to be involved in lipid metabolism [catalytic activity: linoleoyl-CoA + ah(2) + O(2) = gamma- linolenoyl-CoA + a + 2 H(2)O]
YP_906378.1	cytoplasmic protein; thought to be involved in lipid metabolism [catalytic activity: linoleoyl-CoA + ah(2) + O(2) = gamma- linolenoyl-CoA + a + 2 H(2)O]
YP_906379.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; function unknown, probably involved in cellular metabolism.
YP_906380.1	cytoplasmic protein
YP_906381.1	cytoplasmic protein; possibly involved in transcriptional mechanism (probably sigma factor promoting attachment of the RNA polymerase to specific initiation sites)
YP_906382.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; probably involved in transport of undeterminated substrate (possibly cations Na/H) across the membrane. thought to be responsible for the translocation of the substrate across the membrane.
YP_906383.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; function unknown but has a putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [inorganic ion transport and metabolism]
YP_906384.1	membrane protein
YP_906385.1	functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins
YP_906386.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; function unknown but has domain identity with sigma 54 modulation protein
YP_906387.1	cytoplasmic protein; function unknown, but contains amidophosphoribosyltransferase domain
YP_906388.1	membrane protein
YP_906389.1	membrane protein
YP_906390.1	membrane protein; sensor part of a two component regulatory system.
YP_906391.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS. Also detected in the membrane fraction by proteomics.; cytoplasmic protein; transcriptional activator part of a two component regulatory system.
YP_906392.1	catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP)
YP_906393.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_906394.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_906395.1	catalyzes the formation of L-homocysteine from S-adenosyl-L-homocysteine
YP_906396.1	cytoplasmic protein; probably involved in a transcriptional mechanism
YP_906397.1	cytoplasmic protein; involved in the hydrocarbon hydroxylating system to convert conversion of dodecane to lauric acid, which transfers electrons from NADH to rubredoxin reductase and then through rubredoxin to alkane 1 monooxygenase.
YP_906398.1	cytoplasmic protein; involved in the hydrocarbon hydroxylating system, which transfers electrons from NADH to rubredoxin reductase and then through rubredoxin to alkane 1 monooxygenase.
YP_906399.1	membrane protein; thought to be involved in cationic amino acid transport across the membrane. responsible for the translocation of the substrate across the membrane.
YP_906401.1	cytoplasmic protein; function unknown but contains dehydrogenase domain
YP_906402.1	cytoplasmic protein; this enzyme converts D-mannose 6-phosphate to D- fructose 6-phosphate [catalytic activity: D-mannose 6- phosphate = D-fructose 6-phosphate]
YP_906403.1	cytoplasmic protein
YP_906404.1	converts mannose-6-phosphate to mannose-1-phosphate; the resulting product is then converted to GDP-mannose by ManC which is then used in the synthesis of mannose-containing glycoconjugates that are important for mediating entry into host cells
YP_906405.1	cytoplasmic protein
YP_906406.1	cytoplasmic protein
YP_906407.1	cytoplasmic protein; involved in transcriptional mechanism.
YP_906408.1	catalyzes the formation of the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) and GMP from actyl (2) diphospho-(5')guanosine (LPPG) to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO)
YP_906409.1	catalyzes the addition of gamma linked glutamate to 7,8-didemethyl-8-hydroxy-5-deazariboflavin coenzyme F420-0)
YP_906410.1	cytoplasmic protein; causes DNA methylation.
YP_906411.1	cytoplasmic protein
YP_906412.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; involved in GDP-mannose biosynthesis and biosynthesis of nucleotide-activated glycero-manno-heptose (D-alpha-D pathway): generates GDP-mannose and phosphate from GTP and alpha-D-mannose 1-phosphate. ManB product is needed for all mannosyl glycolipids and polysaccharides which, like rhamnosyl residues, are an important part of the mycobacterium envelope [catalytic activity: alpha-D- mannose 1-phosphate + GTP = GDP-mannose + phosphate]
YP_906413.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; involved in cell wall arabinogalactan linker formation: uses dTDP-L-rhamnose as substrate to insert the rhamnosyl residue into the cell wall. seems to be essential for mycobacterial viability.
YP_906414.1	cytoplasmic protein; involved in dTDP-L-rhamnose biosynthesis: converts dTDP-6-deoxy-L-lyxo-4-hexulose to dTDP-L-rhamnose with the concomitant oxidation of NADPH to NADP+ [catalytic activity: dTDP-6-deoxy-L-lyxo-4-hexulose + NADPH = dTDP-L- rhamnose + NADP+]
YP_906415.1	membrane protein
YP_906417.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; function unknown.
YP_906418.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; metal cation-transporting ATPase; possibly catalyzes the transport of undetermined metal cation with the hydrolyse of ATP [catalytic activity: ATP + H(2)O + undeterminated metal cation(in) = ADP + phosphate + undeterminated metal cation(out)]
YP_906419.1	cytoplasmic protein
YP_906420.1	cytoplasmic protein; function unknown, potential regulatory function
YP_906421.1	cytoplasmic protein
YP_906422.1	membrane protein; sensor part of the two component regulatory system.
YP_906423.1	membrane protein
YP_906424.1	cytoplasmic protein
YP_906425.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; function unknown, but involved in lipid metabolism [catalytic activity: acyl-CoA + ETF = 2,3-dehydroacyl-CoA + reduced ETF]
YP_906426.1	Detected in the membrane fraction by proteomics (LC- MS/MS); cytoplasmic protein; nvolved in purine biosynthesis (sixth step) this subunit can alone transform air to cair, but in association with PurK, which possesses an ATPase activity, an enzyme complex is produced which is capable of converting air to cair efficiently under physiol
YP_906427.1	With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway
YP_906428.1	membrane protein
YP_906429.1	membrane protein
YP_906430.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; BirA acts both as a biotin-operon repressor and as the enzyme that synthesizes the corepressor, acetyl- CoA:carbon-dioxide ligase. this protein also activates biotin to form biotinyl-5'-adenylate and transfers the biotin moiety to biotin-accepting proteins [catalytic activity: ATP + biotin + apo-[acetyl-CoA:carbon-dioxide ligase (ADP forming)] = AMP + pyrophosphate + [acetyl- CoA:carbon-dioxide ligase (ADP forming)]]
YP_906431.1	Detected in the cytoplamic fraction by LC-MS/MS. Also detected in the extracellular matrix  and membrane fraction by proteomics.; cytoplasmic protein; key enzyme in the catabolic pathway of odd-chain fatty acids, isoleucine, threonine, methionine, and valine [catalytic activity: ATP + propionyl-CoA + CO(2) + H(2)O = ADP + orthophosphate + methylmalonyl-CoA]
YP_906432.1	cytoplasmic protein
YP_906433.1	Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell
YP_906434.1	cytoplasmic protein; possibly a sulfotransferase involved in the formation of thiosulfate [catalytic activity: thiosulfate + cyanide = sulfite + thiocyanate]
YP_906435.1	cytoplasmic protein; probably involved in Fe-S center assembly
YP_906436.1	Detected in the cytoplasmic fraction by proteomics (2D-LC-MS/MS) Also detected in the extracellular matrix and membrane fraction by proteomics.; cytoplasmic protein; involved in long-chain fatty acid synthesis (at the first step) carries two functions: biotin carboxyl carrier protein and biotin carboxyltransferase [catalytic activity: ATP + biotin-carboxyl-carrier protein + CO(2) = ADP + orthophosphate + carboxybiotin-carboxyl-carrier protein]
YP_906437.1	cytoplasmic protein; function unknown but contains 3 modules for the potential synthesis of a tripeptide
YP_906438.1	cytoplasmic protein; involved in transcriptional mechanism.
YP_906439.1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor is a general stress response regulator; expressed in stationary phase and under nitrogen depletion and cold shock
YP_906440.1	cytoplasmic protein; binds to sigma and blocks its ability to form an RNA polymerase holoenzyme. regulates negatively SigF and negatively regulated by RsfA and RsfB.
YP_906441.1	cytoplasmic protein
YP_906442.1	cytoplasmic protein
YP_906443.1	membrane protein
YP_906444.1	catalyzes the formation of 2-aminoadipate 6-semiladehyde and glutamate from lysine and 2-oxoglutarate
YP_906445.1	cytoplasmic protein; involved in transcriptional mechanism.
YP_906446.1	cytoplasmic protein
YP_906447.1	cytoplasmic protein; involved in L-alpha-aminoadipic acid (L-AAA) biosynthesis (in the second step; the first step is promoted by Lat enzyme.
YP_906448.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; involved in transcriptional mechanism.
YP_906449.1	cytoplasmic protein; involved in damage reversal. DNA N-glycosylase with an ap lyase activity. required for the repair of oxidative DNA damage (oxidized pyrimidines)
YP_906450.1	membrane protein; function unknown, lipolytic enzyme involved in cellular metabolism.
YP_906451.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_906452.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_906453.1	membrane protein; involved in active transport of inorganic phosphate across the membrane (import) this is one of the proteins required for binding-protein-mediated phosphate transport.
YP_906454.1	cytoplasmic protein
YP_906455.1	membrane protein; generates sulfate and phenol from phenol sulfate [catalytic activity: a phenol sulfate + H(2)O = a phenol + sulfate]
YP_906456.1	cytoplasmic protein; catalyses the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi)
YP_906457.1	cytoplasmic protein; involved in transcriptional regulation of active transport of inorganic phosphate across the membrane.
YP_906458.1	membrane protein; function unknown but may be involved in glutamate biosynthesis [catalytic activity: 2 L-glutamate + NADP(+) = L-glutamine + 2-oxoglutarate + NADPH]
YP_906459.1	Detected in the membrane fraction by proteomics (2D- LC-MS/MS); cytoplasmic protein; involved in aerobic respiration and oxydation of glycerol. reduces an acceptor and generates glycerone phosphate from SN-glycerol 3-phosphate. possibly play a role in metabolism of riboflavin, fad,FMN [catalytic activity: SN-glycerol 3-phosphate + acceptor = glycerone phosphate + reduced acceptor]
YP_906460.1	catalyzes the reduction of nonspecific electron acceptors such as 2,6-dimethyl-1,4-benzoquinone and 5-hydroxy-1,4-naphthaquinone; does not have lipoamide dehydrogenase activity
YP_906461.1	cytoplasmic protein
YP_906462.1	cytoplasmic protein
YP_906463.1	membrane protein; function unknown, hydrolysis of L-amino acids.
YP_906464.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; involved in cellular metabolism, active on carbon aliphatic amides and/or on many aromatic amides [catalytic activity : a monocarboxylic acid amide + H(2)O = a monocarboxylate + NH(3)]
YP_906465.1	catalyzes the formation of a purine and ribose phosphate from a purine nucleoside; in E. coli this enzyme functions in xanthosine degradation
YP_906466.1	cytoplasmic protein; converts D-mannose 1-phosphate to D-mannose 6- phosphate.
YP_906467.1	Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate
YP_906468.1	cytoplasmic protein; involved in cellular metabolism: acting on ester bonds [catalytic activity: an orthophosphoric monoester + H(2)O = an alcohol + orthophosphate]
YP_906469.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein
YP_906470.1	cytoplasmic protein; function unknown but contains hydrolase domain
YP_906471.1	cytoplasmic protein; function unknown. thought to be regulated by LexA
YP_906472.1	membrane protein; function unknown but contains permease domain and may be involved in nucleotide transport (cytosine/purines) and metabolism/coenzyme metabolism
YP_906473.1	Detected in the cytoplamic fraction by LCMSMS; cytoplasmic protein; function unknown, contains xylanase/chitin deacetylase domain
YP_906474.1	catalyzes the formation of S-ureidoglycolate and urea from allantoate
YP_906475.1	cytoplasmic protein
YP_906476.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_906477.1	membrane protein
YP_906478.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_906479.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_906480.1	cytoplasmic protein; transposition of an insertion sequence
YP_906481.1	cytoplasmic protein; transposition of an insertion sequence
YP_906482.1	cytoplasmic protein
YP_906483.1	membrane protein; involved in phosphate transport.
YP_906484.1	catalyzes the reduction of 3'-phosphoadenylyl sulfate into sulfite
YP_906485.1	cytoplasmic protein
YP_906486.1	cytoplasmic protein
YP_906487.1	secreted protein; generates oxidized ferredoxin from ferredoxin [catalytic activity: reduced ferredoxin + NADP(+) = oxidized ferredoxin + NADPH]
YP_906488.1	cytoplasmic protein; ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.
YP_906489.1	Detected in the membrane fraction by proteomics (2D- LC-MS/MS); cytoplasmic protein; function unknown. possibly involved in transcriptional mechanism.
YP_906490.1	membrane protein
YP_906491.1	cytoplasmic protein; function unknown but contains zinc binding domain found at the N-terminus of the ClpX protein. ClpX is an ATPase which functions both as a substrate specificity component of the ClpXP protease and as a molecular chaperone.
YP_906492.1	membrane protein; hydrolysis of lipids (bound ester)
YP_906493.1	cytoplasmic protein
YP_906495.1	cytoplasmic protein; function unknown, probably involved in cellular metabolism.
YP_906496.1	cytoplasmic protein
YP_906497.1	membrane protein
YP_906498.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_906499.1	cytoplasmic protein; involved in transcriptional mechanism.
YP_906500.1	cytoplasmic protein; function unknown but contains oxidoreductase domain
YP_906502.1	PPE61; membrane protein
YP_906503.1	secreted protein; involved in phospholipid biosynthesis [catalytic activity: CDP-diacylglycerol + H(2)O = CMP + phosphatidate]
YP_906504.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_906505.1	cytoplasmic protein
YP_906507.1	cytoplasmic protein
YP_906508.1	membrane protein
YP_906509.1	cytoplasmic protein
YP_906510.1	cytoplasmic protein
YP_906511.1	cytoplasmic protein
YP_906512.1	cytoplasmic protein
YP_906513.1	membrane protein
YP_906514.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; could help control the pool of 3'-phosphoadenoside 5'-phosphosulfate, or its use in sulfite synthesis (by similarity)
YP_906515.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_906516.1	cytoplasmic protein; required for the transposition of the insertion element IS2606
YP_906517.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_906518.1	potential pseuodgene; cytoplasmic protein
YP_906519.1	PPE51_1; detected in the membranr fraction by proteomics.; membrane protein
YP_906520.1	cytoplasmic protein; function unknown but contains metal-dependant hydrolase domain identity
YP_906521.1	cytoplasmic protein; function unknown but has domain identity to UbiE, a methylase involved in ubiquinone/menaquinone biosynthesis
YP_906522.1	cytoplasmic protein
YP_906523.1	cytoplasmic protein; involved in transcriptional mechanism.
YP_906524.1	molecular chaperone
YP_906525.1	cytoplasmic protein
YP_906526.1	cytoplasmic protein; probably involved in a transcriptional mechanism
YP_906527.1	cytoplasmic protein; involved in the hydrocarbon hydroxylating system to convert conversion of dodecane to lauric acid, which transfers electrons from NADH to rubredoxin reductase and then through rubredoxin to alkane 1 monooxygenase.
YP_906528.1	cytoplasmic protein; involved in the hydrocarbon hydroxylating system, which transfers electrons from NADH to rubredoxin reductase and then through rubredoxin to alkane 1 monooxygenase.
YP_906529.1	membrane protein; thought to be involved in fatty acid metabolism. generates octanol and oxidized rubredoxin from octane and reduced rubredoxin. also hydroxylates fatty acids in the omega-position [catalytic activity: octane + reduced rubredoxin + (O)2 = 1-octanol + oxidized rubredoxin + H(2)O]
YP_906530.1	cytoplasmic protein; required for the transposition of the insertion element IS2606
YP_906531.1	cytoplasmic protein; function unknown, probably involved in cellular metabolism, possibly electron transfer.
YP_906532.1	cytoplasmic protein; cellular metabolism
YP_906533.1	cytoplasmic protein
YP_906534.1	cytoplasmic protein
YP_906535.1	Also detected in the membrane fraction by proteomics.; cytoplasmic protein; oxidizes fatty acids using specific components (by similarity) [catalytic activity: (3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H(2)O]
YP_906536.1	secreted protein
YP_906537.1	cytoplasmic protein; involved in transcriptional mechanism.
YP_906538.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein
YP_906539.1	cytoplasmic protein
YP_906540.1	cytoplasmic protein; function unknown but high domain identity with O- Methyltransferases involved in polyketide biosynthesis
YP_906541.1	membrane protein
YP_906542.1	cytoplasmic protein; function unknown, but high domain identity with epimerases and phenazine biosynthesis-like protein, PhzC/PhzF which is involved in dimerisation of two 2,3- dihydro-3-oxo-anthranilic acid molecules to create Pca by P. fluorescens.
YP_906543.1	cytoplasmic protein
YP_906544.1	membrane protein
YP_906545.1	secreted protein; function unknown but has ribonuclease I domain identity
YP_906546.1	membrane protein; function unknown but domain identity with mechanosensitive ion channels
YP_906547.1	Detected in the membrane fraction by proteomics (LC- MS/MS) Also detected in the cytoplasmic fraction by 2D-LC- MS/MS; membrane protein; function unknown but contains multiple functional domains including vWA domain (von willebrand factor (vWF) type a domain; found in extracellular proteins, like integrins, and mediates adhesion. also contains a vault protein inter-alpha-trypsin domain
YP_906548.1	cytoplasmic protein
YP_906549.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_906550.1	cytoplasmic protein
YP_906551.1	cytoplasmic protein; function unknown but contains glutamine synthetase catalytic domain
YP_906552.1	PE_PGRS39; membrane protein
YP_906553.1	secreted protein
YP_906554.1	cytoplasmic protein; function unknown, probably involved in cellular metabolism.
YP_906555.1	membrane protein; function unknown. possibly transporter involved in transport of undeterminated substrate (possibly cationic amino acids) across the membrane: so responsible for the translocation of the substrate across the membrane.
YP_906556.1	cytoplasmic protein; function unknown, high domain identity with saccharopine dehydrogenase. this family comprises three structural domains that can not be separated in the linear sequence. in some organisms this enzyme is found as a bifunctional polypeptide with lysine ketoglutarate.
YP_906557.1	catalyzes the formation of 4-aminobutanoate from 4-aminobutanal; involved in putrescine degradation
YP_906558.1	cytoplasmic protein; involved in transcriptional mechanism.
YP_906559.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS. Also detected in the membrane fraction by proteomics (2D-LC-MS/MS); membrane protein; function unknown, high domain identity with BioA, aminotransferase [coenzyme metabolism]
YP_906560.1	cytoplasmic protein; function unknown - possible oxidoreducatse
YP_906561.1	cytoplasmic protein; possibly involved in transcriptional mechanism.
YP_906562.1	function unknown, probably involved in cellular metabolism
YP_906563.1	cytoplasmic protein
YP_906564.1	cytoplasmic protein
YP_906565.1	cytoplasmic protein; catalyzes the one electron reduction of certain quinones [catalytic activity: NADPH + quinone = NADP+ + semiquinone]
YP_906566.1	membrane protein; hydrolyzes a monocarboxylic acid amide and generates a monocarboxylate [catalytic activity: a monocarboxylic acid amide + H(2)O = a monocarboxylate + NH(3)]
YP_906567.1	membrane protein; hydrolyzes sphingomyelin in addition to phosphatidylcholine. probable virulence factor implicated in the pathogenesis of mycobacterium tuberculosis at the level of intracellular survival, by the alteration of cell signaling events or by direct cytotoxicity [catalytic activity: a phosphatidylcholine + H(2)O = 1,2- diacylglycerol + choline phosphate]
YP_906568.1	cytoplasmic protein; function unknown but domain identity with streptomyces scabies esterase protein
YP_906569.1	functions in thiamine (vitamin B1) biosynthesis; in Bacillus subtilis this enzyme catalyzes the formation of thiazole from dehydroxyglycine and 1-deoxy-D-xylulose-5-phosphate and ThiS-thiocarboxylate
YP_906570.1	cytoplasmic protein; part of the thiamine biosynthesis operon. ThiS (thiamins) is a 66 aa protein involved in sulphur transfer. this is coded in the thiCEFSGH operon in E. coli.
YP_906571.1	membrane protein; involved in thiamine biosynthesis.
YP_906572.1	Condenses 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate to form thiamine monophosphate
YP_906573.1	cytoplasmic protein; possibly involved in the go system responsible for removing an oxidatively damaged form of guanine (7,8- dihydro-8-oxoguanine) from DNA and the nucleotide pool. 8- oxo-dGTP is inserted opposite da and dc residues of template DNA with almost equal efficiency thus leading to a.T to G.C transversions. MutT specifically degrades 8-oxo- dGTP to the monophosphate [catalytic activity: 8-oxo-dGTP + H2O = 8-oxo-DGMP + pyrophosphate]
YP_906574.1	membrane protein
YP_906575.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; involved in active transport of glutamine across the membrane (import) interacts with the glutamine- transport system.
YP_906576.1	Detected in the secreted protein fraction by proteomics.; membrane protein; involved in signal transduction (via phosphorylation) thought to regulate amino-acid uptake and stationary-phase metabolism. phosphorylates the peptide substrate myelin basic protein (MBP) at serine residues [catalytic activity: ATP + a protein = ADP + a P
YP_906577.1	cytoplasmic protein
YP_906578.1	AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA
YP_906579.1	cytoplasmic protein; catalyzes oxidation of glucose-6-phosphate to 6- phosphogluconolactone using coenzyme F420 (an *-hydroxy-5- deazaflavin derivative) as the electron acceptor.
YP_906580.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_906581.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_906582.1	cytoplasmic protein; function unknown but has domain identity with acetyltransferases
YP_906583.1	membrane protein
YP_906584.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; function unknown, but involved in lipid degradation.
YP_906585.1	cytoplasmic protein; required for the transposition of the insertion element IS2606.
YP_906586.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_906587.1	cytoplasmic protein
YP_906588.1	cytoplasmic protein
YP_906589.1	Part of a 2158bp section not present in M. marinum M strain. However LipU orthologs are found in MTB and M. avium paratb; membrane protein; function unknown but probably involved in lipid hydrolysis
YP_906590.1	cytoplasmic protein
YP_906591.1	catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis
YP_906592.1	cytoplasmic protein
YP_906593.1	membrane protein
YP_906594.1	membrane protein; function unknown, possibly involved in transport of metal ions across the membrane.
YP_906595.1	cytoplasmic protein; involved in sulfation: activity towards typical ceramide glycolipids and trehalose glycolipids.
YP_906596.1	cytoplasmic protein
YP_906597.1	cytoplasmic protein
YP_906598.1	cytoplasmic protein
YP_906599.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein
YP_906600.1	Detected in the membrane fraction by proteomics (LC- MS/MS) Also detected in the cytoplasmic fraction by 2D-LC- MS/MS.; membrane protein
YP_906601.1	cytoplasmic protein; could be involved in biotin biosynthesis (at the first step) [catalytic activity: 6-carboxyhexanoyl-CoA + L- alanine = 8-amino-7-oxononanoate + CoA + CO2]
YP_906602.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_906603.1	cytoplasmic protein
YP_906604.1	cytoplasmic protein
YP_906605.1	cytoplasmic protein
YP_906606.1	cytoplasmic protein
YP_906607.1	membrane protein; function unknown but may be a regulatory protein as it contains a signal transduction histidine kinase domain
YP_906608.1	cytoplasmic protein; function unknown but may be involved in RNA methylation
YP_906609.1	cytoplasmic protein; involved in rRNA methylation
YP_906610.1	PE_PGRS51; membrane protein
YP_906611.1	Detected in the membrane fraction by proteomics (2D- LC-MS/MS); cytoplasmic protein; function unknown, probably involved in cellular metabolism
YP_906612.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_906614.1	cytoplasmic protein; this protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
YP_906615.1	cytoplasmic protein
YP_906616.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_906618.1	cytoplasmic protein; function unknown, probably involved in cellular metabolism
YP_906619.1	membrane protein
YP_906620.1	membrane protein
YP_906621.1	membrane protein; function unknown, but thought involved in host cell invasion.
YP_906622.1	membrane protein; function unknown, but thought to be involved in host cell invasion.
YP_906623.1	membrane protein; function unknown, but thought to be involved in host cell invasion.
YP_906624.1	membrane protein; function unknown, but thought to be involved in host cell invasion.
YP_906625.1	membrane protein; function unknown, but probably part of Mce3 operon and member of YrbE family
YP_906626.1	membrane protein
YP_906627.1	cytoplasmic protein
YP_906628.1	cytoplasmic protein; function unknown, domain identity with ketosteroid isomerase-related proteins
YP_906629.1	cytoplasmic protein; function unknown but weak domain identity with two- component response regulators
YP_906630.1	cytoplasmic protein; thought to oxidize a wide variety of aliphatic and aromatic aldehydes.
YP_906631.1	cytoplasmic protein
YP_906632.1	cytoplasmic protein; involved in transcriptional mechanism; repression of the Mce3 operon. could also have a regulatory action on the Mce2 operon.
YP_906633.1	membrane protein; maybe required for the translocation of the substrate across the membrane.
YP_906634.1	cytoplasmic protein
YP_906635.1	function unknown, probably involved in cellular metabolism
YP_906636.1	cytoplasmic protein; involved in riboflavin biosynthesis [catalytic activity : GTP + 3 H(2)O = formate + 2,5-diamino-6-hydroxy- 4-(5-phosphoribosylamino)pyrimidine + diphosphate]
YP_906637.1	cytoplasmic protein; function unknown, probably involved in cellular metabolism
YP_906638.1	cytoplasmic protein; this enzyme acts on epoxides (alkene oxides, oxiranes) and Arene oxides. plays a role in xenobiotic metabolism by degrading potential toxic epoxides. also determines steady-state levels of physiological mediators.
YP_906639.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; function unknown, may be involved in electron transfer.
YP_906640.1	cytoplasmic protein; function unknown, probably involved in cellular metabolism
YP_906641.1	cytoplasmic protein; function unknown, but supposed involvement in lipid degradation.
YP_906642.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; function unknown, but supposed involvement in lipid degradation.
YP_906643.1	antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein
YP_906644.1	cytoplasmic protein; function unknown but domain identity with Fe-S oxidoreductases
YP_906645.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_906646.1	cytoplasmic protein; required for the transposition of the insertion element IS2606
YP_906647.1	cytoplasmic protein
YP_906648.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_906649.1	cytoplasmic protein; involved in transcriptional mechanism
YP_906650.1	membrane protein
YP_906651.1	cytoplasmic protein; function unknown but contains dihydrofolate reductase domain
YP_906652.1	cytoplasmic protein; function unknown but has weak indentity with hydrolase domains
YP_906653.1	cytoplasmic protein
YP_906654.1	cytoplasmic protein
YP_906655.1	cytoplasmic protein
YP_906656.1	cytoplasmic protein; function unknown: involved in carbohydrate transport and metabolism
YP_906657.1	cytoplasmic protein; involved in oxidative stress response.
YP_906658.1	cytoplasmic protein; required for the transposition of the insertion element IS2606
YP_906659.1	catalyzes the transformation of hydroxyatrazine to N-isopropylammelide and ethylamine in the atrazine degradation pathway.
YP_906660.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_906661.1	cytoplasmic protein
YP_906662.1	cytoplasmic protein
YP_906663.1	activates fatty acids by binding to coenzyme A
YP_906664.1	cytoplasmic protein; involved in transcriptional mechanism.
YP_906665.1	membrane protein
YP_906666.1	cytoplasmic protein
YP_906667.1	cytoplasmic protein; wide specificity for D-amino acids. also acts on glycine [catalytic activity: a D-amino acid + H2O + O2 = a 2-oxo acid + NH3 + H2O2]
YP_906668.1	membrane protein
YP_906669.1	cytoplasmic protein
YP_906670.1	cytoplasmic protein
YP_906671.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_906672.1	cytoplasmic protein
YP_906673.1	membrane protein
YP_906674.1	cytoplasmic protein; involved in transcriptional mechanism.
YP_906675.1	cytoplasmic protein; function unknown, probably involved in cellular metabolism.
YP_906676.1	cytoplasmic protein; thought to be involved in fatty acid degradation. FadB and FadA are the alpha and BetA subunits of the multifunctional enzyme complex of the fatty acid degradation cycle.
YP_906677.1	cytoplasmic protein
YP_906678.1	cytoplasmic protein; involved in transcriptional regulation.
YP_906679.1	cytoplasmic protein
YP_906680.1	cytoplasmic protein
YP_906681.1	Detected in the membrane fraction by proteomics (LC- MS/MS); cytoplasmic protein
YP_906682.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_906683.1	cytoplasmic protein; involved in glyoxylate bypass, an alternative to the tricarboxylic acid cycle [catalytic activity: isocitrate = succinate + glyoxylate]
YP_906684.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_906685.1	Detected in the membrane fraction by proteomics (LC- MS/MS); cytoplasmic protein
YP_906686.1	membrane protein; function unknown, lipolytic enzyme probably involved in cellular metabolism
YP_906687.1	Detected in the membrane fraction by proteomics (2D- LC-MS/MS); membrane protein
YP_906688.1	membrane protein; involved in (I) tranposition of IS2606 and (II) transport of sialic acid across the membrane. responsible for the translocation of the substrate across the membrane.
YP_906689.1	cytoplasmic protein; CinA is the first gene in the competence-inducible (cin) operon, and is thought to be specifically required at some stage in the process of transformation.
YP_906690.1	membrane protein
YP_906691.1	Truncated wrt to orthologues, missing last 12aa - potential pseudogene; membrane protein; function unknown but contains predicted phosphatase domain
YP_906692.1	cytoplasmic protein
YP_906693.1	hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine
YP_906694.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; function unknown but significant domain identity with O-Methyltransferases involved in polyketide biosynthesis
YP_906695.1	cytoplasmic protein; function unknown, probably involved in cellular metabolism
YP_906696.1	cytoplasmic protein; generates aldehyde or ketone from alcohol [catalytic activity: alcohol + NADP(+) = aldehyde or ketone + NADPH]
YP_906697.1	cytoplasmic protein; function unknown but some similarity with YceI-like family proteins. in E. coli YceI is a base-induced periplasmic protein. its function has not yet been characterised.
YP_906698.1	membrane protein
YP_906699.1	cytoplasmic protein
YP_906700.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_906701.1	Detected in the membrane fraction by proteomics (LC- MS/MS) Also detected in the cytoplasm by proteomics.; membrane protein; involved in cell wall mycoloylation. proteins of the antigen 85 complex are responsible for the high affinity of mycobacteria to fibronectin. possesses a mycolyltransferase activity required for the biogenesis of trehalose dimycolate (cord factor), a dominant structure necessary for maintaining cell wall integrity.
YP_906702.1	cytoplasmic protein
YP_906703.1	cytoplasmic protein; function unknown, probably involved in cellular metabolism.
YP_906704.1	cytoplasmic protein; function unknown, probably involved in cellular metabolism.
YP_906705.1	catalyzes the interconversion of chorismate to prephenate
YP_906706.1	secreted protein; thought to promote the resuscitation and growth of dormant, nongrowing cell. could also stimulate the growth of several other high G+C Gram+ organisms, E.G. mycobacterium avium, mycobacterium bovis (BCG), mycobacterium kansasii, mycobacterium smegmatis.
YP_906707.1	cytoplasmic protein
YP_906708.1	cytoplasmic protein; function unknown, probably involved in cellular metabolism
YP_906709.1	membrane protein
YP_906710.1	cytoplasmic protein; cytochromes P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
YP_906711.1	cytoplasmic protein
YP_906712.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_906713.1	cytoplasmic protein; required for the transposition of the insertion element IS2606.
YP_906714.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_906715.1	cytoplasmic protein
YP_906716.1	cytoplasmic protein
YP_906717.1	cytoplasmic protein; involved in iron storage (may perform analogous functions in iron detoxification and storage as that of animal ferritins); ferritin is an intracellular molecule that stores iron in a soluble, nontoxic, readily available form. the functional molecule, which is composed of 24 chains, is roughly spherical and contains a central cavity in which the polymeric ferric iron core is deposited.
YP_906718.1	function unknown but like upstream ORF, contains bacterioferritin-associated ferredoxin domain
YP_906719.1	cytoplasmic protein; oxidizes fatty acids using specific components (by similarity) [catalytic activity: (3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H(2)O]
YP_906720.1	Also detected in the membrane fraction by proteomics (LC-MS/MS); cytoplasmic protein
YP_906721.1	cytoplasmic protein
YP_906722.1	cytoplasmic protein
YP_906723.1	Also detected in the extracellular matrix and the membrane fraction by proteomics.; cytoplasmic protein; involved in oxidative stress response.
YP_906724.1	Detected in the cytoplasmic and membrane fractions by LCMSMS and also detected in the extracellular matrix by proteomics.; cytoplasmic protein; involved in oxidative stress response.
YP_906725.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; involved in trehalose biosynthesis (protective effect) converts maltose to trehalose. mycobacteria can produce trehalose from glucose 6-phosphate and UDP-glucose (the OtsA-OtsB pathway) from glycogen-like alpha(1-->4)- linked glucose polymers (the TreY-TreZ pathway) and from maltose (the TreS pathway)
YP_906726.1	Detected in the membrane fraction by proteomics (2D- LC-MS/MS); membrane protein; involved in respiration; catalyzes conversion of lactate into pyruvate [catalytic activity: (S)-lactate + 2 ferricytochrome C = pyruvate + 2 ferrocytochrome C]
YP_906727.1	cytoplasmic protein; function unknown but probably plays a role in posttranslational protein modification, turnover and chaperone functions.
YP_906728.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS. Also detected in the membrane fraction by proteomics (2D-LC-MS/MS); cytoplasmic protein
YP_906729.1	cytoplasmic protein
YP_906730.1	membrane protein
YP_906731.1	cytoplasmic protein; function unknown but contains nucleoside- diphosphate-sugar epimerase domain identity - a domain associated with cell envelope biogenesis, carbohydrate transport and metabolism.
YP_906732.1	Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation
YP_906733.1	cytoplasmic protein; function unknown but contains acetyltransferase domain identity
YP_906734.1	cytoplasmic protein; function unknown, probably involved in cellular metabolism
YP_906735.1	Detected in the membrane and secreted fractions by proteomics (2D-LC-MS/MS); membrane protein; bacterial enzyme that splits fructose-6-P and/or xylulose-5-P with the aid of inorganic phosphate into either acetyl-P and erythrose-4-p and/or acetyl-P and glyeraldehyde-3-p
YP_906736.1	cytoplasmic protein
YP_906737.1	cytoplasmic protein; catalyzes the reversible oxidation of ethanol to acetaldehyde with the concomitant reduction of NAD
YP_906738.1	membrane protein
YP_906739.1	Two isoform were also detected by proteomics in the cytoplasm.; membrane protein; function unknown could mediate bacterial attachment to host cells.
YP_906740.1	membrane protein; part of the binding-protein-dependent transport system ModABC for molybdenum; responsible for energy coupling to the transport system.
YP_906741.1	cytoplasmic protein
YP_906742.1	cytoplasmic protein; function unknown but shows high identity with sulfide-quinone reductase from chlorobium tepidum
YP_906743.1	cytoplasmic protein; function unknown, but possible involved in lipid metabolism
YP_906744.1	membrane protein; part of the binding-protein-dependent transport system ModABC for molybdenum; responsible for the translocation of the substrate across the membrane.
YP_906745.1	membrane protein; involved in the active transport of molybdenum into the cell across the membrane (import) part of the binding- protein-dependent transport system ModABC.
YP_906746.1	cytoplasmic protein; function unknown, probably involved in cellular metabolism.
YP_906747.1	cytoplasmic protein; function unknown, probably involved in cellular metabolism
YP_906748.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; transfer of electrons from NADH to the respiratory chain. the immediate electron acceptor for the enzyme is believed to be ubiquinone. does not couple the redox reaction to proton translocation.
YP_906749.1	cytoplasmic protein; UreD is involved in activation of the urease enzyme via the UreD-UreF-UreG-urease complex and is required for urease nickel metallocenter assembly
YP_906750.1	cytoplasmic protein; UreG is required for functional incorporation of the urease nickel metallocenter. it is not known whether UreG binds GTP or some other nucleotide.
YP_906751.1	cytoplasmic protein; required for the insertion of the nickel ion at the active site of the urease protein
YP_906752.1	ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alpha) and 3 ureAB (gamma/beta) subunits
YP_906753.1	cytoplasmic protein; involved in the conversion of UreA to NH3 [catalytic activity: UreA + H2O = CO2 + 2 NH3]
YP_906754.1	UreA, with UreB and UreC catalyzes the hydrolysis of urea into ammonia and carbon dioxide; nickel metalloenzyme; accessory proteins UreD, UreE, UreF, and UreG are necessary for assembly of the metallocenter
YP_906755.1	cytoplasmic protein; function unknown but domain identity suggests possibly involved in aromatic compound catabolism
YP_906756.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; involved in transcriptional mechanism.
YP_906757.1	membrane protein; function unknown but significant domain identity with HtpX, Zn-dependent protease with chaperone function.
YP_906758.1	catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate
YP_906759.1	catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate
YP_906760.1	cytoplasmic protein; valine and isoleucine biosynthesis (first step) [catalytic activity : 2-acetolactate + CO(2) = 2 pyruvate]
YP_906761.1	SecA2; functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond to SecA2; which is non-essential and seems to play a role in secretion of a subset of proteins
YP_906762.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; thought to be involved in cardiolipin biosynthesis; generates cardiolipin from phosphatidylglycerol and CDP- diacylglycerol [catalytic activity : may be: phosphatidylglycerol + phosphatidylglycerol -> cardiolipin + glycerol, or: CDP-diacylglycerol + glycerol 3-phosphate = CMP + 3-(3-phosphatidyl)-glycerol 1-phosphate]
YP_906763.1	cytoplasmic protein
YP_906764.1	membrane protein
YP_906765.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_906766.1	part of multienzyme complex composed of H, L, P, and T proteins which catalyzes oxidation of glycine to yield carbon dioxide, ammonia, 5,10-CH2-H4folate and a reduced pyridine nucleotide; protein H is involved in transfer of methylamine group from the P to T protein; covalently bound to a lipoyl cofactor
YP_906767.1	Detected in the cytoplamic fraction by LC-MS/MS; cytoplasmic protein; function unknown but contains an FHA domain. these domains are involved in nuclear signalling domain and may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine.
YP_906768.1	cytoplasmic protein; function unknown but high N-terminal domain identity with the MerR helix-turn-helix transcription regulator.
YP_906769.1	cytoplasmic protein
YP_906770.1	cytoplasmic protein; function unknown but contains MerR helix-turn-helix transcription regulatory domain
YP_906771.1	acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine
YP_906772.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; may act on a wide range of 1-haloalkanes, haloalcohols, haloalkenes and some haloaromatic compounds [catalytic activity: 1-haloalkane + H(2)O, a primary alcohol + halide]
YP_906773.1	cytoplasmic protein
YP_906774.1	Detected in the membrane fraction by proteomics (2D- LC-MS/MS); membrane protein; function unknown but weak C-term identity with vWA domain (von willebrand factor type a domain) this domain is found in extracellular proteins, like integrins, and mediates adhesion.
YP_906775.1	catalyzes the formation of malate from glyoxylate and acetyl-CoA
YP_906776.1	PE_PGRS34; membrane protein
YP_906777.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; thought to be involved in active transport of drugs across the membrane (export): multidrugs resistance by an export mechanism. responsible for energy coupling to the transport system and for the translocation of the substrate across the membrane.
YP_906778.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_906779.1	cytoplasmic protein; required for the transposition of the insertion element IS2606
YP_906780.1	PE_PGRS9_1; membrane protein
YP_906781.1	translation fusion of two CDS caused by frameshift at 3' end of hypothetical protein MON6433 (3398526); membrane protein; function unknown, probably involved in cellular metabolism
YP_906782.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_906783.1	membrane protein; involved in lipid desaturation
YP_906784.1	cytoplasmic protein; function unknown - weak domain identity with lipase/esterase proteins
YP_906785.1	cytoplasmic protein; function unknown, probably involved in cellular metabolism
YP_906786.1	membrane protein; thought to be involved in Mg2+ transport (import) may act as an accessory protein for MgtB so mediating magnesium influx into the cytosol [catalytic activity: ATP + H(2)O + mg(2+)(out) = ADP + phosphate + mg(2+)(in)]
YP_906787.1	cytoplasmic protein
YP_906788.1	PPE30; membrane protein
YP_906789.1	PPE32; membrane protein
YP_906790.1	PPE31; membrane protein
YP_906791.1	PPE31_1; membrane protein
YP_906792.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS. Also detected in the membrane fraction by proteomics (LC-MS/MS); membrane protein; function unknown, but domain identity to aaa, ATPase family proteins that have been associated with chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.
YP_906793.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_906794.1	Also detected in the cytoplasmic fraction by 2D-LC- MS/MS.; membrane protein; function unknown proteolytic activity but subtilases are a family of serine proteases that can play a role in posttranslational modification.
YP_906795.1	Detected in the membrane fraction by proteomics (2D- LC-MS/MS); membrane protein
YP_906796.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS. Also detected in the membrane fraction by proteomics (2D-LC-MS/MS); cytoplasmic protein
YP_906797.1	Also Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; secreted protein
YP_906798.1	Detected in the secreted fraction by proteomics.; secreted protein
YP_906799.1	PE19; membrane protein
YP_906800.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_906801.1	secreted protein
YP_906802.1	PPE26; Detected in the membrane fraction by proteomics (2D- LC-MS/MS); membrane protein
YP_906803.1	PE19_1; membrane protein
YP_906804.1	PPE25; membrane protein
YP_906805.1	cytoplasmic protein; ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.
YP_906806.1	cytoplasmic protein; cytochromes P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
YP_906807.1	Detected in the membrane fraction by proteomics.; membrane protein; function unknown but has multiple FtsK/SpoIIIE protein domains. This domain contains a putative ATP binding P-loop motif and is found in the FtsK cell division protein from E. coli and the stage III sporulation protein E SpoIIIE.
YP_906808.1	Detected in the membrane fraction by proteomics.; membrane protein
YP_906809.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; transfers a segment of a (1,4)-alpha-D-glucan to a new 4-position in an acceptor, which may be glucose or (1,4)-alpha-D-glucan
YP_906810.1	cytoplasmic protein
YP_906811.1	cytoplasmic protein
YP_906812.1	cytoplasmic protein
YP_906813.1	cytoplasmic protein
YP_906814.1	cytoplasmic protein
YP_906815.1	membrane protein; function unknown but contains signal peptide
YP_906816.1	cytoplasmic protein; cytochromes P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
YP_906817.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; function unknown - contains signal peptide
YP_906818.1	cytoplasmic protein
YP_906819.1	cytoplasmic protein
YP_906820.1	cytoplasmic protein
YP_906821.1	cytoplasmic protein; involved in transcriptional mechanism.
YP_906822.1	cytoplasmic protein
YP_906823.1	cytoplasmic protein; could cause methylation of unknown substrate.
YP_906824.1	cytoplasmic protein; thioredoxin participates in various redox reactions through the reversible oxidation of its active center dithiol, to a disulfide, & catalyzes dithiol-disulfide exchange reactions.
YP_906825.1	cytoplasmic protein
YP_906826.1	cytoplasmic protein
YP_906827.1	cytoplasmic protein
YP_906829.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; function unknown but contains aminopeptidase domain identity
YP_906830.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; function unknown, probably involved in cellular metabolism
YP_906831.1	cytoplasmic protein
YP_906832.1	membrane protein
YP_906833.1	cytoplasmic protein; involved in transcriptional mechanism.
YP_906834.1	cytoplasmic protein; cytochromes P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
YP_906835.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_906836.1	secreted protein
YP_906837.1	Also detected in the membrane fraction by proteomics (LC-MS/MS); cytoplasmic protein; function unknown, probably involved in cellular metabolism
YP_906838.1	function unknown, lipolytic enzyme probably involved in cellular metabolism.
YP_906839.1	cytoplasmic protein; function unknown but domain identity suggests it may be a signal-transduction protein
YP_906840.1	cytoplasmic protein; function unknown role in cellular metabolism
YP_906841.1	cytoplasmic protein; domain identity suggests this CDS encodes an AraD- like, ribulose-5-phosphate 4-epimerase. this enzyme and related epimerases and aldolases are involved in carbohydrate transport and metabolism.
YP_906842.1	cytoplasmic protein; function unknown but domain identity suggests this CDS is Acs-like, acyl-coenzyme a synthetases/AMP-(fatty) acid ligases involved in lipid metabolism.
YP_906843.1	cytoplasmic protein
YP_906844.1	membrane protein; function unknown but some domain identity with Zn- dependent proteases
YP_906845.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_906846.1	Detected in the membrane fraction by proteomics (LC- MS/MS) Also detected in the cytoplasmic fraction by 2D-LC- MS/MS.; membrane protein; thought to be involved in active transport of undeterminated substrate (possibly lipooligosaccharide) across the membrane. responsible for energy coupling to the transport system and for the translocation of the substrate across the membrane.
YP_906847.1	cytoplasmic protein
YP_906848.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_906849.1	cytoplasmic protein; required for the transposition of the insertion element IS2606.
YP_906850.1	cytoplasmic protein; function unknown, probably involved in cellular metabolism.
YP_906851.1	membrane protein; involved in transport of unknown substrate across the membrane.
YP_906852.1	cytoplasmic protein
YP_906853.1	cytoplasmic protein
YP_906854.1	Detected in the cytoplamic and membrane fractions by LCMSMS; cytoplasmic protein; possibly involved in detoxification reactions following oxidative damage to lipids.
YP_906855.1	cytoplasmic protein
YP_906856.1	cytoplasmic protein
YP_906857.1	Detected in the secreted protein fractions by 2D-LC- MS/MS.; secreted protein
YP_906858.1	membrane protein; H(+)-stimulated, highly selective, divalent cation uptake system. responsible for the translocation of the divalent metal across the membrane.
YP_906859.1	cytoplasmic protein
YP_906860.1	PPE8; membrane protein
YP_906861.1	cytoplasmic protein
YP_906862.1	cytoplasmic protein; involved in the synthesis of decaprenyl diphosphate, a molecule which has a central role in the biosynthesis of most features of the mycobacterial cell wall. adds seven more isoprene units to omega,E, Z- farnesyl diphosphate and releases decaprenyl diphosphate.
YP_906863.1	membrane protein
YP_906864.1	cytoplasmic protein; transfer of electrons from NADH to the respiratory chain. the immediate electron acceptor for the enzyme is believed to be ubiquinone. does not couple the redox reaction to proton translocation.
YP_906865.1	Detected in the membrane fraction by proteomics (2D- LC-MS/MS); secreted protein; function unknown but contains signal peptide
YP_906866.1	cytoplasmic protein; function unknown but may play a role in protein translation
YP_906867.1	membrane protein; part of a potassium transport system.
YP_906868.1	the Vibrio parahaemolyticus gene VP2867 was found to be a potassium/proton antiporter; can rapidly extrude potassium against a potassium gradient at alkaline pH when cloned and expressed in Escherichia coli
YP_906869.1	membrane protein
YP_906870.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_906871.1	Detected in the membrane fraction by proteomics.; membrane protein; involved in signal transduction (via phosphorylation) thought to be involved in membrane transport [catalytic activity: ATP + a protein = ADP + a phosphoprotein]
YP_906872.1	cytoplasmic protein
YP_906873.1	membrane protein; thought to be involved in transport amino acids across the membrane.
YP_906874.1	cytoplasmic protein
YP_906875.1	membrane protein; function unknown. seems to influence both cell surface interactions among mycobacteria and the interactions of bacteria with macrophages.
YP_906876.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; involved in active transport of unknown sugars across the membrane. responsible for the translocation of the substrate across the membrane.
YP_906878.1	Detected in the membrane fraction by proteomics (LC- MS/MS); secreted protein; function unknown but contains signal peptide and domain identity with periplasmic component of the tol biopolymer transport system.
YP_906879.1	NADP-dependent semialdehyde dehydrogenase; part of alternative pathway from alpha-ketoglutarate to succinate
YP_906880.1	cytoplasmic protein; function unknown but domain identity with penicillin V acylase and related amidases
YP_906881.1	secreted protein; function unknown but contains signal peptide
YP_906882.1	membrane protein
YP_906883.1	cytoplasmic protein; function unknown, probably involved in cellular metabolism.
YP_906884.1	cytoplasmic protein
YP_906885.1	cytoplasmic protein; involved in biosynthesis of membrane ether-linked lipids. catalyzes the trans-addition of the three molecules of Ipp onto DMAPP to form geranylgeranyl pyrophosphate which is a precursor of the ether-linked lipids. catalyzes the consecutive condensation of
YP_906886.1	cytoplasmic protein; function unknown but may be involved in inhibition of protein synthesis by cleavage of mRNA
YP_906887.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; membrane protein
YP_906888.1	cytoplasmic protein
YP_906889.1	cytoplasmic protein; involved in transcriptional mechanism.
YP_906890.1	cytoplasmic protein
YP_906891.1	cytoplasmic protein
YP_906892.1	Detected in the membrane fraction by proteomics; cytoplasmic protein; function unknown role in carbohydrate transport and metabolism
YP_906893.1	cytoplasmic protein
YP_906894.1	secreted protein
YP_906895.1	secreted protein
YP_906896.1	membrane protein; this CDS encodes a 3-oxo-5-alpha-steroid 4- dehydrogenase. This family consists of 3-oxo-5-alpha- steroid 4-dehydrogenases. also known as steroid 5-alpha- reductase, the reaction catalysed by this enzyme is: 3-oxo- 5-alpha-steroid + acceptor <=> 3
YP_906897.1	membrane protein
YP_906898.1	cytoplasmic protein
YP_906899.1	cytoplasmic protein; function unknown, has HTH motif of a resolvase
YP_906900.1	cytoplasmic protein; required for the transposition of the insertion element IS2606
YP_906901.1	cytoplasmic protein; TatD related DNAse. this family of proteins are related to a large superfamily of metalloenzymes. TatD, a member of this family has been shown experimentally to be a DNAse enzyme.
YP_906902.1	cytoplasmic protein; function unknown, contains PP-loop ATPase domain
YP_906903.1	cytoplasmic protein
YP_906904.1	Detected in the secreted protein fraction by proteomics.; membrane protein
YP_906905.1	cytoplasmic protein
YP_906906.1	cytoplasmic protein; required for the transposition of the insertion element IS2606.
YP_906907.1	cytoplasmic protein; required for the transposition of the insertion element IS2606.
YP_906908.1	cytoplasmic protein; required for the transposition of the insertion element IS2606.
YP_906909.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_906910.1	cytoplasmic protein; required for the transposition of the insertion element IS2606.
YP_906911.1	cytoplasmic protein; Integration/excision of an unknown mycbacteriophage
YP_906912.1	synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains
YP_906913.1	Catalyzes the formation of (d)CDP from ATP and (d)CMP
YP_906914.1	cytoplasmic protein; possible role in ribosome biogenesis and protein translation
YP_906915.1	cytoplasmic protein
YP_906916.1	cytoplasmic protein
YP_906917.1	cytoplasmic protein; function unknown, possible role in chromosome partioning.
YP_906918.1	cytoplasmic protein
YP_906919.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_906920.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_906921.1	cytoplasmic protein; required for the transposition of the insertion element IS2606.
YP_906922.1	membrane protein
YP_906923.1	cytoplasmic protein
YP_906924.1	Detected in the cytoplasmic and secreted fractions by proteomics.; secreted protein
YP_906925.1	PE_PGRS33; membrane protein; function unknown. seems to influence both cell surface interactions among mycobacteria and the interactions of bacteria with macrophages
YP_906926.1	with PdxST is involved in the biosynthesis of pyridoxal 5'-phosphate; PdxT catalyzes the hydrolysis of glutamine to glutamate and ammonia; PdxS utilizes the ammonia to synthesize pyridoxal 5'-phosphate
YP_906927.1	cytoplasmic protein; function unknown, lipolytic enzyme involved in cellular metabolism. can hydrolyze a broad range of acyl- CoA thioesters.
YP_906928.1	with PdxT forms pyridoxal 5'-phosphate from glutamine, either ribose 5-phosphate or ribulose 5-phosphate, and either glyceraldehyde 3-phosphate or dihydroxyacetone phosphate
YP_906929.1	cytoplasmic protein; function unknown but contains a NUDIX domain
YP_906930.1	membrane protein; involved in the first mannosylation step in phosphatidylinositol mannoside biosynthesis (transfer of mannose residues onto pi, leading to the synthesis of phosphatidylinositol monomannoside)
YP_906931.1	Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA
YP_906932.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; catalyzes the transfer of a free alcohol (inositol) onto CDP-diacylglycerol. the product of this putative ORF seems be essential to mycobacteria [catalytic activity: CDP-diacylglycerol + myo-inositol = CMP + phosphatidyl 1D- myo-inositol]
YP_906933.1	cytoplasmic protein; function unknown, but location and domain identity to hydrlases suggests it could be involved in lipid metabolism.
YP_906934.1	catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr)
YP_906935.1	cytoplasmic protein
YP_906937.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein
YP_906938.1	membrane protein
YP_906939.1	cytoplasmic protein
YP_906940.1	cytoplasmic protein; involved in electron transfer.
YP_906941.1	membrane protein; involved in excretion of nitrite produced by the dissimilatory reduction of nitrate. responsible for the translocation of the substrate across the membrane.
YP_906942.1	cytoplasmic protein; methylation of unknown substrate.
YP_906943.1	cytoplasmic protein
YP_906944.1	membrane protein
YP_906945.1	membrane protein
YP_906946.1	cytoplasmic protein; involved in lipid metabolism.
YP_906947.1	cytoplasmic protein
YP_906948.1	cytoplasmic protein; function unknown but contains phosphoribosyltransferase domain
YP_906949.1	cytoplasmic protein
YP_906950.1	cytoplasmic protein; function unknown, but involved in lipid degradation.
YP_906951.1	membrane protein
YP_906952.1	cytoplasmic protein; function unknown but contains identity with a pfam01740 STAS domain. the STAS (after sulphate transporter and antisigma factor antagonist) domain is found in the C terminal region of sulphate transporters and bacterial antisigma factor antagonists. it has been Sug
YP_906953.1	cytoplasmic protein; it catalyses the conversion of hydrogen peroxide to water and molecular oxygen and is thus involved in the protection of cells from the toxic effects of peroxides.
YP_906954.1	cytoplasmic protein
YP_906955.1	cytoplasmic protein; involved in transcriptional mechanism.
YP_906956.1	cytoplasmic protein; function unknown, in M. tuberculosis H37Rv this gene induced by cadmium (see hotter et al., 2001)
YP_906957.1	cytoplasmic protein; involved in transcriptional mechanism.
YP_906958.1	secreted protein
YP_906959.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_906960.1	membrane protein
YP_906961.1	cytoplasmic protein
YP_906962.1	membrane protein; function unknown but has domain identity with lysophospholipases
YP_906963.1	Detected in the secreted fraction by 2D-LC-MS/MS.; secreted protein
YP_906964.1	cytoplasmic protein; function unknown, possibly hydrolyzes peptides and/or proteins in presence of ATP.
YP_906965.1	secreted protein
YP_906966.1	cytoplasmic protein
YP_906967.1	cytoplasmic protein
YP_906968.1	cytoplasmic protein; involved in riboflavin biosynthesis (at the second and third steps) converts 2,5-diamino-6-(ribosylamino)- 4(3H)-pyrimidinone 5'-phosphate into 5-amino-6- (ribosylamino)-2,4(1H,3H)-pyrimidinedione 5'-phosphate [catalytic activity 1: 2,5-diamino-6-hydroxy-4-(5- phosphoribosylamino)pyrimidine + H(2)O = 5-amino-6-(5- phosphoribosylamino)uracil + NH(3)] [catalytic activity 2: 5-amino-6-(5-phosphoribitylamino)uracil + NADP(+) = 5- amino-6-(5-phosphoribosylamino)uracil + NADPH]
YP_906969.1	Detected in the membrane fraction by proteomics (2D- LC-MS/MS); membrane protein
YP_906970.1	cytoplasmic protein; function unknown but contains a SelR domain. these family of reductases are involved in the reduction of methionine sulfoxides in proteins
YP_906971.1	cytoplasmic protein
YP_906972.1	cytoplasmic protein; function unknown but contains identity to pfam06778, chlorite dismutase. this family contains chlorite dismutase enzymes of bacterial and archaeal origin. this enzyme catalyses the disproportionation of chlorite into chloride and oxygen. note that many family memb
YP_906973.1	catalyzes the formation of protoporphyrin IX from protoporphyrinogen IX
YP_906974.1	catalyzes the formation of coproporphyrinogen from uroporphyrinogen III
YP_906975.1	Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA
YP_906976.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein
YP_906977.1	cytoplasmic protein
YP_906978.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_906979.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; membrane protein
YP_906980.1	catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate
YP_906981.1	cytoplasmic protein
YP_906982.1	membrane protein; thought to be involved in active transport of arsenical compounds across the membrane (export): arsenic resistance by an export mechanism. responsible for the translocation of the substrate across the membrane.
YP_906983.1	membrane protein; thought to be involved in active transport of unidentified antibiotic across the membrane (export): antibiotic resistance by an export mechanism. responsible for the translocation of the substrate across the membrane.
YP_906984.1	cytoplasmic protein; function unknown but domain identity suggests this CDS encodes TrmA, a protein related to tRNA (uracil-5-)- methyltransferases.
YP_906985.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; function unknown but domain identity suggests a role in amino acid transport
YP_906986.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; part of a potassium transport system.
YP_906987.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS; cytoplasmic protein; part of a potassium transport system.
YP_906988.1	membrane protein
YP_906989.1	cytoplasmic protein
YP_906991.1	cytoplasmic protein
YP_906992.1	catalyzes the formation of dUMP from dUTP
YP_906993.1	membrane protein
YP_906994.1	Detected in the secreted fraction by 23D-LC-MS/MS.; cytoplasmic protein
YP_906995.1	secreted protein
YP_906996.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; in E. coli, SuhB mutation (SuhB2) enhances the synthesis of sigma(32) and suppresses temperature- sensitive growth of the RpoH15 mutant. may affect some step(S) of protein synthesis by facilitating the function of GroE or other heat shock proteins.
YP_906997.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; catalyzes the phosphorylation of glucose using polyphosphate or ATP as the phosphoryl donor. GTP, UTP and CTP can replace ATP as phosphoryl donor [catalytic activity: (phosphate)(N) + d-glucose = (phosphate)(N-1) + d-glucose 6-phosphate]
YP_906998.1	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
YP_906999.1	cytoplasmic protein; function unknown but contains pfam01042 domain, endoribonuclease L-PSP. endoribonuclease active on single- stranded mRNA. inhibits protein synthesis by cleavage of mRNA. previously thought to inhibit protein synthesis initiation. this protein may also be involved I
YP_907000.1	cytoplasmic protein
YP_907001.1	cytoplasmic protein
YP_907002.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_907003.1	cytoplasmic protein
YP_907004.1	membrane protein
YP_907005.1	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; sigma factors in this cluster are active during stationary phase
YP_907006.1	cytoplasmic protein; transcriptional regulatory protein (repressor and activator), iron-binding repressor of siderophore biosynthesis and iron uptake. seems to regulate a variety of genes encoding a variety of proteins E.G. transporters, proteins involved in siderophore synthesis and iron storage, members of the PE/PPE family, enzymes involved in lipid metabolism, transcriptional regulatory proteins, etc. also activator of BfrA gene.
YP_907007.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_907008.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_907009.1	membrane protein; function unknown but contains weak similarity to V8- like Glu-specific endopeptidases involved in amino acid transport and metabolism.
YP_907010.1	Also detected in the extracellular matrix by proteomics.; cytoplasmic protein
YP_907011.1	cytoplasmic protein; function unknown, probably involved in cellular metabolism.
YP_907012.1	cytoplasmic protein; function unknown but contains identity to an epimerase involved in phenazine biosynthesis.
YP_907013.1	cytoplasmic protein
YP_907014.1	Also detected in the membrane fraction by proteomics (2D-LC-MS/MS); membrane protein
YP_907015.1	membrane protein; in M. tuberculosis H37Rv thought to be regulated by LexA.
YP_907016.1	Represses a number of genes involved in the response to DNA damage
YP_907017.1	Also detected in the cytoplasmic and membrane fractions by LC-MS/MS.; membrane protein
YP_907018.1	cytoplasmic protein; function unknown, but involved in lipid metabolism.
YP_907019.1	cytoplasmic protein; possibly a GTPase, modulating activity of HflK and HflC proteins.
YP_907020.1	involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate
YP_907021.1	IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity
YP_907022.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.
YP_907023.1	membrane protein
YP_907024.1	membrane protein; involved in signal transduction (via phosphorylation) thought to be involved in arabinan metabolism, phosphorylating perhaps EmbR [catalytic activity: ATP + a protein = ADP + a phosphoprotein]
YP_907025.1	cytoplasmic protein
YP_907026.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_907027.1	catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A)
YP_907028.1	binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities
YP_907029.1	catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs
YP_907030.1	cytoplasmic protein
YP_907031.1	cytoplasmic protein
YP_907032.1	function unknown, probably involved in cellular metabolism.
YP_907033.1	Detected in the membrane fraction by proteomics (LC- MS/MS); cytoplasmic protein; function unknown but contains a LimA, limonene-1,2- epoxide hydrolase domain.
YP_907034.1	membrane protein
YP_907035.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; function unknown but domain identity to COG1842, PspA, phage shock protein a (IM30), suppresses sigma54- dependent transcription
YP_907036.1	cytoplasmic protein; possibly involved in transcriptional mechanism.
YP_907037.1	cytoplasmic protein; involved in acidic phospholipid biosynthesis. this protein probably catalyzes the committed step to the synthesis of the acidic phospholipids [catalytic activity: CDP-diacylglycerol + glycerol-3-phosphate = CMP + 3-(3- phosphatidyl)-glycerol 1-phosphate]
YP_907038.1	catalyzes the conversion of l-glutamate to a-N-acetyl-l-glutamate in arginine biosynthesis
YP_907039.1	membrane protein; possibly involved in cell division processes
YP_907040.1	Detected in the cytoplasmic and secreted fractions by 2D-LC-MS/MS.; cytoplasmic protein
YP_907041.1	catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis
YP_907042.1	Detected in the membrane fraction by proteomics (2D- LC-MS/MS); membrane protein; function unknown domain identity suggests this is a methylase involved in secondary metabolism (polyketides)
YP_907043.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_907044.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_907045.1	cytoplasmic protein; function unknown but domain identity suggests NADPH- dependent FMN reductase
YP_907046.1	cytoplasmic protein; involved in transcriptional mechanism.
YP_907047.1	cytoplasmic protein; function unknown, but similar to various oxidoreductases and enzymes involved in polyketides synthesis
YP_907048.1	cytoplasmic protein; involved in transcriptional mechanism.
YP_907049.1	cytoplasmic protein; cytochromes P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
YP_907050.1	cytoplasmic protein
YP_907051.1	cytoplasmic protein
YP_907052.1	cytoplasmic protein
YP_907053.1	cytoplasmic protein; function unknown, supposed involvement in lipid metabolism.
YP_907054.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_907055.1	cytoplasmic protein; function unknown but potential nucleic-acid-binding domain
YP_907056.1	cytoplasmic protein
YP_907057.1	cytoplasmic protein
YP_907058.1	Detected in the membrane fraction by proteomics; cytoplasmic protein; function unknown, but involved in lipid metabolism.
YP_907059.1	Also detected in the membrane fraction by proteomics (LC-MS/MS); cytoplasmic protein; function unknown, supposed involved in cellular metabolism.
YP_907060.1	catalyzes the ATP-dependent formation of a phosphodiester at the site of a single-strand break in duplex DNA
YP_907061.1	membrane protein
YP_907062.1	cytoplasmic protein; involved in transcriptional mechanism
YP_907063.1	secreted protein
YP_907064.1	cytoplasmic protein; required for the transposition of the insertion element IS2606
YP_907065.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_907066.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; acts as a chaperone. involved in induction by stress conditions E.G. heat shock. possibly has an ATPase activity. in M. tuberculosis H37Rv it is regulated positively by SigH  and negatively by HspR.
YP_907067.1	cytoplasmic protein
YP_907068.1	cytoplasmic protein
YP_907069.1	membrane protein; involved in transport of multidrugs (tetraphenylphosphonium, erythromycin, ethidium bromide, acriflavine, safranin O, pyronin Y, etc) across the membrane (export): multidrugs resistance by an export mechanism (conferes resistance to toxic compounds by removing them for the cells) responsible for the translocation of the substrate across the membrane.
YP_907070.1	cytoplasmic protein; involved in transcriptional mechanism.
YP_907071.1	cytoplasmic protein
YP_907073.1	cytoplasmic protein; function unknown, probably involved in cellular metabolism.
YP_907074.1	Detected in the membrane fraction by proteomics (2D- LC-MS/MS); membrane protein; involved in 4-aminobutyrate (GabA) degradation pathway [catalytic activity: succinate semialdehyde + NAD(P)(+) + H(2)O = succinate + NAD(P)H]
YP_907075.1	cytoplasmic protein; function unknown, but involved in lipid degradation.
YP_907076.1	membrane protein; function unknown but contains Cdd pfam03982, DAGAT, diacylglycerol acyltransferase domain.
YP_907077.1	cytoplasmic protein
YP_907078.1	Good u/s rbs.; function unknown, probably involved in cellular metabolism.
YP_907079.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_907080.1	cytoplasmic protein; required for the transposition of the insertion element IS2606.
YP_907081.1	cytoplasmic protein; function unknown but has domain similarity to quinoprotein amine dehydrogenases
YP_907082.1	catalyzes the interconversion of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate
YP_907083.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_907084.1	cytoplasmic protein
YP_907085.1	cytoplasmic protein
YP_907086.1	cytoplasmic protein
YP_907087.1	cytoplasmic protein
YP_907088.1	cytoplasmic protein; interconversion of acetate and oxaloacetate from citrate [catalytic activity: citrate = acetate + oxaloacetate]
YP_907089.1	cytoplasmic protein; function unknown but domain identity suggests transcriptional regulator
YP_907090.1	membrane protein
YP_907091.1	cytoplasmic protein
YP_907092.1	cytoplasmic protein; function unknown but domain homology to arylsulfatase a ( AslA )and related enzymes.
YP_907093.1	cytoplasmic protein
YP_907094.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_907095.1	cytoplasmic protein
YP_907096.1	cytoplasmic protein; function unknown, first 70 aa missing WRT to orthologues
YP_907097.1	secreted protein
YP_907098.1	cytoplasmic protein
YP_907099.1	membrane protein
YP_907100.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_907101.1	cytoplasmic protein; catalyzes the first step in the biosynthesis of 2- methylthio-N6-(delta(2)-isopentenyl)-adenosine adjacent to the anticodon of several tRNA species [catalytic activity: isopentenyl diphosphate + tRNA = pyrophosphate + tRNA containing 6-isopentenyladenosine]
YP_907102.1	functions in degradation of stringent response intracellular messenger ppGpp; in Escherichia coli this gene is co-transcribed with the toxin/antitoxin genes mazEF; activity of MazG is inhibited by MazEF in vitro; ppGpp inhibits mazEF expression; MazG thus works in limiting the toxic activity of the MazF toxin induced during starvation; MazG also interacts with the GTPase protein Era
YP_907103.1	cytoplasmic protein
YP_907104.1	cytoplasmic protein
YP_907105.1	cytoplasmic protein
YP_907106.1	secreted protein
YP_907107.1	secreted protein
YP_907108.1	secreted protein
YP_907109.1	cytoplasmic protein
YP_907110.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_907111.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_907112.1	cytoplasmic protein; function unknown but has domain similarity to predicted flavin-nucleotide-binding proteins
YP_907113.1	catalyzes the formation of glutamate from glutamine
YP_907114.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_907115.1	cytoplasmic protein; required for the transposition of the insertion element IS2606.
YP_907116.1	cytoplasmic protein; function unknown but contains lysophospholipase domain
YP_907117.1	cytoplasmic protein; function unknown, contains predicted nucleic acid- binding pin domain
YP_907118.1	membrane protein
YP_907119.1	Detected in the membrane and the cytoplamic fractions  by proteomics.; secreted protein; function unknown but corresponds to antigen 84 of mycobacterium tuberculosis (Wag31) (see hermans et al., 1995) predicted to contain significant amount of coiled coil structure.
YP_907120.1	membrane protein
YP_907121.1	cytoplasmic protein
YP_907122.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein
YP_907123.1	Detected in the membrane fraction by proteomics.; membrane protein
YP_907124.1	GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function
YP_907125.1	cytoplasmic protein; this protein may be involved in septum formation (by similarity)
YP_907126.1	Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis
YP_907127.1	UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis
YP_907128.1	membrane protein; function unknown function in cell division
YP_907129.1	UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation
YP_907130.1	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
YP_907131.1	Detected in the membrane fraction by proteomics.; membrane protein; involved in cell wall formation; peptidoglycan biosynthesis.
YP_907132.1	involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate
YP_907133.1	membrane protein
YP_907134.1	membrane protein; involved in peptidoglycan biosynthesis.
YP_907135.1	membrane protein
YP_907136.1	cytoplasmic protein
YP_907137.1	MraZ; UPF0040; crystal structure shows similarity to AbrB
YP_907138.1	membrane protein
YP_907139.1	cytoplasmic protein; function unknown but contains acyl-CoA N- acyltransferase superfamily domain
YP_907140.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_907141.1	cytoplasmic protein
YP_907142.1	Detected in the membrane fraction by proteomics.; cytoplasmic protein; involved in lipid biosynthesis.
YP_907143.1	membrane protein
YP_907144.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein
YP_907145.1	membrane protein; involved in signal transduction (via phosphorylation)
YP_907146.1	cytoplasmic protein; required for the transposition of the insertion element IS2606.
YP_907147.1	cytoplasmic protein; HMGR is a tightly regulated enzyme, which catalyzes the synthesis of coenzyme a and mevalonate in isoprenoid synthesis. in mammals, this is the rate limiting committed step in cholesterol biosynthesis. bacteria, such as pseudomonas mevalonii, which rely solely on mevalonate for their carbon source, catalyze the reverse reaction, using an NAD-dependent HMGR to deacetylate mevalonate into 3- hydroxy-3-methylglutaryl-CoA.
YP_907148.1	membrane protein; part of the mevalonate pathway for isoprenoid synthesis. possible regulatory role in mevalonate metabolism. converts (R)-5-phosphomevalonate to (R)-5- diphosphomevalonate.
YP_907149.1	cytoplasmic protein; key enzyme in isoprenoid synthesis. converts (R)-5- diphosphomevalonate to phosphate + isopentenyl diphosphate +  CO(2)
YP_907150.1	cytoplasmic protein; converts (R)-mevalonate to (R)-5-phosphomevalonate (ATP dependant)
YP_907151.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_907152.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; involved in fatty acid biosynthesis. catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl- acp. kas III catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. possesses both acetoacetyl-acp synthase and acetyl transacylase activities [catalytic activity: acyl- [acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]]
YP_907153.1	cytoplasmic protein; involved in chorismate biosynthesis
YP_907154.1	cytoplasmic protein
YP_907155.1	membrane protein
YP_907156.1	membrane protein
YP_907157.1	Detected in the membrane fraction by proteomics (2D- LC-MS/MS); membrane protein; transfer of fatty acyl groups
YP_907158.1	cytoplasmic protein
YP_907159.1	cytoplasmic protein; function unknown but domain identity suggests it is an anion-transporting ATPase.
YP_907160.1	cytoplasmic protein
YP_907161.1	cytoplasmic protein
YP_907162.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; function unknown, but involved in lipid metabolism.
YP_907163.1	cytoplasmic protein
YP_907164.1	secreted protein
YP_907165.1	cytoplasmic protein
YP_907166.1	Catalyzes the conversion of N-(5-phospho-D-ribosyl)-anthranilate and diphosphate to anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate
YP_907167.1	cytoplasmic protein; thought to be involved in aerobic respiration.
YP_907168.1	membrane protein; plays a role in aerobic respiration
YP_907169.1	Detected in the membrane fraction by proteomics (2D- LC-MS/MS) Also detected in the cytoplasmic fraction by 2D- LC-MS/MS; membrane protein; role in respiration
YP_907170.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; role in respiration
YP_907171.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_907172.1	membrane protein
YP_907173.1	cytoplasmic protein
YP_907174.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; involved in aerobic respiration. subunit I and II form the functional core of the enzyme complex. electrons originating in cytochrome C are transferred via HemE A and Cu(A) to the binuclear center formed by HemE A3 and Cu(B) (by similarity)
YP_907175.1	cytoplasmic protein; asparagine biosynthesis
YP_907176.1	Detected in the cytoplamic fraction by LCMSMS. Also detected in the membrane fraction by proteomics (2D-LC- MS/MS); cytoplasmic protein; phosphorylation of carbohydrates
YP_907177.1	Detected in the membrane fraction by proteomics (LC- MS/MS); cytoplasmic protein
YP_907178.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; function unknown but domain identity shows similarity to the HesB gene (function unknown) but which is expressed only under nitrogen fixation conditions.
YP_907179.1	membrane protein; function unknown role in carbohydrate transport and metabolism
YP_907180.1	membrane protein
YP_907181.1	cytoplasmic protein; involved in cobalamin biosynthesis.
YP_907182.1	catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide and 5,6-dimethylbenzimidazole
YP_907183.1	catalyzes the formation of adenosylcobalamin from Ado-cobinamide-GDP and alpha-ribazole
YP_907184.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_907185.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_907186.1	membrane protein; function unknown but domain identity with chloride channel superfamily
YP_907187.1	catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids
YP_907188.1	catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein
YP_907189.1	catalyzes the removal of N-terminal amino acids preferably leucine from various peptides
YP_907190.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; thought to be involved in detoxification reactions following oxidative damage to lipids.
YP_907191.1	Detected in the cytoplasmic, the extracellular matrix, and the membrane fraction by proteomics.; cytoplasmic protein; involved in tricarboxylic acid cycle; converts 2- oxoglutarate to succinyl-CoA and CO2
YP_907192.1	function unknown but domain identity with NAD dependent sugar epimerases
YP_907193.1	membrane protein; probably involved in active transport of substrate across the membrane (export)  responsible for energy coupling to the transport system.
YP_907194.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_907195.1	cytoplasmic protein; DNA integration. this sequence contains a DNA breaking-rejoining catalytic core found in phage integrase genes.
YP_907196.1	membrane protein
YP_907197.1	cytoplasmic protein
YP_907198.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_907199.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_907200.1	membrane protein
YP_907201.1	membrane protein; function unknown, hydrolyzes peptides and/or proteins.
YP_907202.1	secreted protein; function unknown, possibly hydrolyzes peptides and/or proteins.
YP_907203.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; membrane protein; function unknown, but may be involved in efflux system (probably sugar or drug transport)
YP_907204.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_907205.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_907206.1	cytoplasmic protein; function unknown but contains a N-term CheY-like response regulator receiver domain and C-term adenylyl/guanylyl cyclase catalytic domain.
YP_907207.1	membrane protein
YP_907208.1	membrane protein
YP_907209.1	cytoplasmic protein; function unknown but has two TetR DNA-binding domains
YP_907210.1	catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine
YP_907211.1	required for the synthesis of the hydromethylpyrimidine moiety of thiamine
YP_907212.1	cytoplasmic protein; function unknown but may be involved in signal transduction pathway as it contains a PAS-like central senor domain and an Antar domain.
YP_907213.1	cytoplasmic protein; function unknown but domain identity shared with the anti-sigma factor antagonist superfamily SpoIIAA
YP_907214.1	cytoplasmic protein
YP_907215.1	cytoplasmic protein; required for the transposition of the insertion element IS2606.
YP_907216.1	cytoplasmic protein; required for the transposition of the insertion element IS2606.
YP_907217.1	Catalyzes a two-step reaction, first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
YP_907218.1	cytoplasmic protein; involved in transcriptional mechanism.
YP_907219.1	cytoplasmic protein; acts as a global negative controlling element, employing fe(2+) as a cofactor to bind the operator of the repressed genes. regulates the expression of several outer- membrane proteins including the iron transport operon (by similarity)
YP_907220.1	cytoplasmic protein
YP_907221.1	catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate
YP_907222.1	involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA
YP_907223.1	catalyzes the hydrolysis of a monocarboxylic acid amid to form a monocarboxylate and ammonia
YP_907224.1	Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome
YP_907225.1	cytoplasmic protein
YP_907226.1	cytoplasmic protein
YP_907227.1	cytoplasmic protein
YP_907228.1	cytoplasmic protein; function unknown but contains tetracycline repressor-like C-terminal superfamily domain.
YP_907229.1	cytoplasmic protein
YP_907230.1	in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase
YP_907231.1	chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion
YP_907232.1	Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons
YP_907233.1	cytoplasmic protein
YP_907234.1	cytoplasmic protein; function unknown but contains identity with antioxidant defence protein Ahp
YP_907235.1	cytoplasmic protein; the sigma factor is an initiation factor that promotes attachment of the RNA polymerase to specific initiation sites and then is released. belongs to the sigma-70 factor family, ECF subfamily.
YP_907236.1	cytoplasmic protein; involved in the biogenesis of the hydroxyphenyloxazoline-containing siderophore mycobactins. this peptide synthase forms amide bound between the carboxylic acid of salicylate and the alpha-amino group of serine (serine/threonine ligation)
YP_907237.1	cytoplasmic protein; involved in the biogenesis of the hydroxyphenyloxazoline-containing siderophore mycobactins. activates amino acid residues that are incorporated into mycobactin (ligation)
YP_907238.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; involved in the biogenesis of the hydroxyphenyloxazoline-containing siderophore mycobactins. probably activates the two lysine residues that are incorporated into mycobactin (lysine ligation)
YP_907239.1	cytoplasmic protein; function unknown but contains acyl-CoA N- acetyltransferase superfamily domain
YP_907240.1	cytoplasmic protein; may be required for the addition of the terminal aa in this Nrp operon
YP_907241.1	cytoplasmic protein; involved in the biogenesis of the hydroxyphenyloxazoline-containing siderophore mycobactins.
YP_907242.1	cytoplasmic protein; involved in the biogenesis of the hydroxyphenyloxazoline-containing siderophore mycobactins.
YP_907243.1	cytoplasmic protein; thought to be involved in the biogenesis of the hydroxyphenyloxazoline-containing siderophore mycobactins.
YP_907244.1	cytoplasmic protein; involved in the biogenesis of the hydroxyphenyloxazoline-containing siderophore mycobactins. this hydroxylase is possibly required for N-hydroxylation of the two lysine residues at some stage during mycobactin assembly [catalytic activity: L-lysine + O(2) = N6-hydroxy- L-lysine + H(2)O. no information can be found if this enzyme is NADPH dependent or independent]
YP_907245.1	membrane protein; involved in the biogenesis of the hydroxyphenyloxazoline-containing siderophore mycobactins (initiation step of mycobactin chain growth) activates the mycobactin ACP in two half-reactions: activates salicylic acid as acyladenylate (adenylation step) + transfers activated salicylate to the MbtA ACP as a thioester (arylation step)
YP_907246.1	cytoplasmic protein; involved in the biogenesis of the hydroxyphenyloxazoline-containing siderophore mycobactins. possibly required for N-hydroxylation of the two lysine residues at some stage during mycobactin assembly.
YP_907247.1	membrane protein
YP_907248.1	cytoplasmic protein; function unknown. possibly involved in transcriptional mechanism.
YP_907249.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; catalyzes the principal conversion of saturated fatty acids to unsaturated fatty acids. thought to convert stearoyl-ACP to oleoyl-ACP by introduction of a cis double bond between carbons delta-9 and delta-10 of the acyl chain [catalytic activity: stearoyl-[acyl-carrier protein] + AH2 + O2 = oleoyl-[acyl-carrier protein] + a + 2 H2O]
YP_907250.1	cytoplasmic protein
YP_907251.1	catalyzes conversion of chorismate to salicylate, in mycobactin siderophore construction; requires Mg(2+) for function
YP_907252.1	cytoplasmic protein
YP_907253.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_907254.1	catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III
YP_907255.1	cytoplasmic protein; generates nitrite from ammonia using oxidized ferredoxin [catalytic activity: ammonia + H(2)O + oh(-) + 3 oxidized ferredoxin = nitrite + 3 reduced ferredoxin] can also act as a sulphite reductase. the sulfite reductases catalyze the reduction of sulfite to sulfide, one step in the biosynthesis of sulfur-containing amino acids and cofactors. this appears to be the only intact nitrite reductase in M. ulcerans.
YP_907256.1	catalyzes the reduction of 3'-phosphoadenylyl sulfate into sulfite
YP_907257.1	membrane protein; function unknown but contains a chelatase superfamily domain. given the presence of other heme- associated CDS in this region and the presence of a chelatase superfamily domain, this CDS may encode a ferrochelatase, catalyzing the last step in HemE biosynthesis.
YP_907258.1	membrane protein; involved in the active transport across the membrane of multiple sulfur-containing compounds, including sulfate and thiosulfate (import) responsible for energy coupling to the transport system.
YP_907259.1	membrane protein; involved in the active transport across the membrane of multiple sulfur-containing compounds, including sulfate and thiosulfate (import) responsible for the translocation of the substrate across the membrane.
YP_907260.1	membrane protein; involved in the active transport across the membrane of multiple sulfur-containing compounds, including sulfate and thiosulfate (import) responsible for the translocation of the substrate across the membrane.
YP_907261.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; involved in the active transport across the membrane of multiple sulfur-containing compounds, including sulfate and thiosulfate (import)
YP_907262.1	cytoplasmic protein
YP_907263.1	cytoplasmic protein; function unknown, probably involved in cellular metabolism
YP_907264.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_907265.1	secreted protein
YP_907266.1	secreted protein
YP_907267.1	binds to the ribosome on the universally-conserved alpha-sarcin loop
YP_907268.1	cytoplasmic protein; function unknown but domain identity with plasmid maintenance toxin superfamily
YP_907269.1	cytoplasmic protein; function unknown but contains 2 Cbs domains
YP_907270.1	member of metallo-beta-lactamase family; the purified enzyme from Escherichia coli forms dimeric zinc phosphodiesterase; in Bacillus subtilis this protein is a 3'-tRNA processing endoribonuclease and is essential while in Escherichia coli it is not; associates with two zinc ions
YP_907271.1	PE_PGRS2; membrane protein
YP_907272.1	PE_PGRS25; membrane protein
YP_907273.1	cytoplasmic protein; function unknown but based on domain identity it may cross-link proteins through an acyl-transfer reaction between the gamma-carboxamide group of peptide-bound glutamine and the epsilon-amino group of peptide-bound lysine.
YP_907274.1	cytoplasmic protein
YP_907275.1	cytoplasmic protein; function unknown but contains two glutathione synthetase ATP-binding superfamily domain-like sequences
YP_907276.1	binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase
YP_907277.1	cytoplasmic protein; possible role in DNA replication. two superfamily domains detected. N-term contains P-loop nucleoside triphosphate hydrolase. C-term contains DNA polymerase III, delta subunit.
YP_907278.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_907279.1	membrane protein; function unknown, predicted membrane metal-binding protein
YP_907280.1	membrane protein; function unknown but domain identity suggests ComEA. a family of DNA uptake protein and related DNA- binding proteins involved in DNA replication, recombination, and repair.
YP_907281.1	Detected in the membrane fraction by proteomics, and in the  cytoplamic and extracellular matrix fractions by LCMSMS; cytoplasmic protein; function unknown, but probable involvement in lipid metabolism.
YP_907282.1	cytoplasmic protein; function unknown, but supposed involvement in lipid metabolism.
YP_907283.1	membrane protein; function unknown but contains FAD/NAD(P)-binding superfamily domain
YP_907284.1	cytoplasmic protein; function unknown but contains superfamily NAD(P)- binding Rossmann-fold domains
YP_907285.1	membrane protein
YP_907286.1	membrane protein
YP_907287.1	membrane protein; function unknown. thought to be involved in lipid transport.
YP_907288.1	cytoplasmic protein; function unknown, contains DegV-like superfamily domain
YP_907289.1	cytoplasmic protein; function unknown but contains esterase/acetylhydrolase superfamily domain
YP_907290.1	cytoplasmic protein; involved in glycolysis [catalytic activity: 2- phosphoglycerate + 2,3-diphosphoglycerate = 3- phosphoglycerate + 2,3-diphosphoglycerate]
YP_907291.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; involved in NAD biosynthesis; catalyzes the reversible adenylation of nicotinate mononucleotide [catalytic activity: ATP + nicotinate ribonucleotide = diphosphate + deamido-NAD(+)] this CDS is a combination of NadD translationally fused at the C-term with an orthologue of Rv2420c. this coupling is not seen in M. marinum nor in other mycobacteria although in other species Rv2420c is immediately d/s of NadD. probably caused by mutational loss of a stop codon.
YP_907292.1	cytoplasmic protein; function unknown but contains a von willebrand factor type a conserved domain
YP_907293.1	Also detected in the membrane fraction by proteomics; cytoplasmic protein; function unknown but contains aaa ATPase domain containing von willebrand factor type a (vWA) domain
YP_907294.1	Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway
YP_907295.1	membrane protein
YP_907296.1	membrane protein; generates 3,'5'-cyclic (A/G)mp and diphosphate (or pyrophosphate) from (A/G)tp.
YP_907297.1	cytoplasmic protein; function unknown but domain identity suggests that it may be a mechanosensitive (ms) ion channel protein with a C-term putative cyclic nucleotide (camp or cGMP) binding domain.
YP_907298.1	cytoplasmic protein; required for the transposition of the insertion element IS2606.
YP_907299.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_907300.1	PE_PGRS33_1; membrane protein; function unknown. seems to influence both cell surface interactions among mycobacteria and the interactions of bacteria with macrophages
YP_907301.1	catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers
YP_907302.1	cytoplasmic protein; function unknown, involved in transcriptional mechanism
YP_907303.1	cytoplasmic protein; function unknown. possibly involved in transcriptional mechanism.
YP_907304.1	catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis
YP_907305.1	essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication
YP_907306.1	involved in the peptidyltransferase reaction during translation
YP_907307.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; involved in translation mechanisms.
YP_907308.1	cytoplasmic protein; thought to be involved in several cellular process.
YP_907309.1	catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate
YP_907310.1	membrane protein
YP_907311.1	cytoplasmic protein; conversion of folates to polyglutamate derivatives. bacteria require folate for the biosynthesis of glycine, methionine, formyl-met-tRNA, thymidylates, purines, and pantothenate [catalytic activity: ATP + {tetrahydrofolyl- [Glu]}(N) + L-glutamate = ADP + phosphate + {tetrahydrofolyl-[Glu]}(n+1)]
YP_907312.1	valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain
YP_907313.1	Detected in the cytoplasm and in the extracellular matrix by proteomics.; cytoplasmic protein; function unknown but N-term contains a bulb-type mannose-specific lectin and C-term contains a LysM, a putative peptidoglycan-binding domain.
YP_907314.1	membrane protein
YP_907315.1	Detected in the membrane fraction by proteomics (2D- LC-MS/MS) Also Detected in the extracellular matrix and the cytoplasmic fractions by proteomics.; membrane protein; function unknown but contains potential saccharopine-like dehydrogenase domain
YP_907316.1	secreted protein; thought to promote the resuscitation and growth of dormant, nongrowing cells. could also stimulate the growth of several other high G+C Gram+ organisms, E.G. mycobacterium avium, mycobacterium bovis (BCG), mycobacterium kansasii, mycobacterium smegmatis.
YP_907317.1	MobA; links a guanosine 5'-phosphate to molydopterin to form molybdopterin guanine dinucleotide; involved in molybdenum cofactor biosynthesis
YP_907318.1	catalyzes the coenzyme A dependent formation of succinyl-CoA from 2-oxoglutarate and ferredoxin
YP_907319.1	Also detected in the membrane fraction by proteomics (2D-LC-MS/MS); cytoplasmic protein; function unknown, probably involved in cellular metabolism.
YP_907320.1	membrane protein; thought to be involved in transport of undeterminated substrate (possibly sugar) across the membrane. responsible for the translocation of the substrate across the membrane.
YP_907321.1	binds and unfolds substrates as part of the ClpXP protease
YP_907322.1	membrane protein; thought to be involved in a transport system across the membrane (perhaps drug transport): responsible for the translocation of the substrate across the membrane.
YP_907323.1	hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates
YP_907324.1	hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates
YP_907325.1	Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer
YP_907326.1	cytoplasmic protein; function unknown, lipolytic enzyme involved in cellular metabolism.
YP_907327.1	secreted protein
YP_907328.1	cytoplasmic protein; hydrolyses DNA (this enzyme may play a significant role in processes leading to recovery from mutagenesis and/or cell death by alkylating agents)
YP_907329.1	catalyzes the interconversion of ribose 5-phosphate to ribulose 5-phosphate; enzyme from E. coli shows allose 6-phosphate isomerase activity
YP_907330.1	PE_PGRS59; membrane protein
YP_907331.1	Also detected in the extracellular matrix by proteomics. Also detected in the membrane fraction by proteomics.; cytoplasmic protein; aminopeptidase with broad substrate specificity to several peptides (could preferentially cleave leucine, arginine and lysine in peptide-bond-containing substrates)
YP_907332.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS. Also detected in the membrane fraction by proteomics (LC-MS/MS); cytoplasmic protein
YP_907333.1	cytoplasmic protein
YP_907334.1	cytoplasmic protein; function unknown but contains McrA, restriction endonuclease domain
YP_907335.1	cytoplasmic protein; oxygen carrier, involved in oxygen transport.
YP_907336.1	cytoplasmic protein; involved in cholesterol metabolism [catalytic activity: cholesterol + O(2) = cholest-4-en-3-one + H(2)O(2)]
YP_907337.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_907338.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_907339.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein
YP_907340.1	cytoplasmic protein; function unknown but some identity with thioesterase domains
YP_907341.1	ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence
YP_907342.1	cytoplasmic protein; function unknown but may play a role in DNA replication, recombination, and repair
YP_907343.1	membrane protein; N-terminus: could be generate serine and phosphate from phosphoserine; may catalyze the last step in the biosynthesis of serine from carbohydrates (the reaction mechanism could be proceed via the formation of a phosphoryl-enzyme intermediates) [catalytic activity 1: phosphoserine + H(2)O = serine + phosphate]  mid-section: involved in phospholipid biosynthesis (at the second step); converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating acyl moiety at the 2 position [catalytic activity 2: acyl-CoA + 1-acyl-SN- glycerol 3-phosphate = CoA + 1,2-diacyl-SN-glycerol 3- phosphate]   c-terminus: contains tola protein domain homology. may serve to anchor this protein in the cm.
YP_907344.1	membrane protein; function unknown but N-term contains a CoA- dependanant acyltransferase domain.
YP_907345.1	cytoplasmic protein; function unknown, lipolytic enzyme involved in cellular metabolism.
YP_907346.1	cytoplasmic protein
YP_907347.1	catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation
YP_907348.1	secreted protein
YP_907349.1	Detected in the membrane fraction by proteomics.; membrane protein; involved in mycolic acids modification. catalyzes unusual S-adenosyl-methionine-dependent transformation of a cis-olefin mycolic acid into a secondary alcohol. catalyzes introduction of a hydroxyl group at the distal position on mycolic acid chains to produce the hydroxyl mycolate. mycolic acids represent a major constituent of the mycobacterial cell wall complex. methyl transfer results in formation of a secondary hydroxy group with an adjacent methyl branch; olefinic mycolic acid methyl transferase.
YP_907350.1	cytoplasmic protein; involved in energy metabolism. the pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA & CO(2) it contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) & lipoamide dehydrogenase (E3) [catalytic activity: acetyl-CoA + dihydrolipoamide = CoA + S- acetyldihydrolipoamide]
YP_907351.1	cytoplasmic protein; involved in energy metabolism. the pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA & CO(2) it contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) & lipoamide dehydrogenase (E3) [catalytic activity: acetyl-CoA + dihydrolipoamide = CoA + S- acetyldihydrolipoamide]
YP_907352.1	cytoplasmic protein; involved in energy metabolism. the pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA & CO(2) it contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) & lipoamide dehydrogenase (E3) [catalytic activity: acetyl-CoA + dihydrolipoamide = CoA + S- acetyldihydrolipoamide]
YP_907353.1	cytoplasmic protein; interconversion of acetate and oxaloacetate from citrate [catalytic activity: citrate = acetate + oxaloacetate]
YP_907354.1	Detected in the cytoplamic fraction by LCMSMS; cytoplasmic protein; function unknown but contains a central MaoC, acyl dehydratase domain
YP_907355.1	cytoplasmic protein; function unknown, but seems involved in metabolism of small branched-chain fatty acids and macrolide antibiotic production. catalyses the alpha, beta- dehydrogenetion of acyl-CoA esters and transfer electrons to ETF, the electron transfer protein.
YP_907356.1	cytoplasmic protein; this protein carries two functions: biotin carboxyl carrier protein and biotin carboxyltransferase. involved in the first step of long-chain fatty acid synthesis [catalytic activity: ATP + biotin-carboxyl-carrier protein + CO(2) = ADP + phosphate + carboxybiotin-carboxyl-carrier protein]
YP_907357.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; involved in various degradation and synthesis [catalytic activity: succinyl-CoA + a 3-oxo acid = succinate + a 3-oxo-acyl-CoA]
YP_907358.1	cytoplasmic protein; involved in fatty acid degradation/synthesis [catalytic activity: succinyl-CoA + a 3-oxo acid = succinate + a 3-oxo-acyl-CoA]
YP_907359.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_907360.1	cytoplasmic protein; involved in transcriptional mechanism.
YP_907361.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_907362.1	membrane protein
YP_907363.1	cytoplasmic protein; function unknown, possibly involved in cellular metabolism.
YP_907364.1	3'-5' exoribonuclease specific for small oligoribonuclotides
YP_907365.1	membrane protein
YP_907366.1	cytoplasmic protein; involved in transcriptional mechanism.
YP_907367.1	membrane protein; function unknown, YrbE family protein that is similar to Ttg2B-like ABC-type transport system involved in resistance to organic solvents, permease component.
YP_907368.1	membrane protein; this family of proteins contains the Mce (mycobacterial cell entry) proteins from mycobacterium tuberculosis. the archetype (Rv0169), was isolated as being necessary for colonisation of, and survival within, the macrophage. this family contains proteins of unknown function from other bacteria.
YP_907369.1	membrane protein; this family of proteins contains the Mce (mycobacterial cell entry) proteins from mycobacterium tuberculosis. the archetype (Rv0169), was isolated as being necessary for colonisation of, and survival within, the macrophage. this family contains proteins of unknown function from other bacteria.
YP_907370.1	membrane protein; this family of proteins contains the Mce (mycobacterial cell entry) proteins from mycobacterium tuberculosis. the archetype (Rv0169), was isolated as being necessary for colonisation of, and survival within, the macrophage. this family contains proteins of unknown function from other bacteria.
YP_907371.1	membrane protein; this family of proteins contains the Mce (mycobacterial cell entry) proteins from mycobacterium tuberculosis. the archetype (Rv0169), was isolated as being necessary for colonisation of, and survival within, the macrophage. this family contains proteins of unknown function from other bacteria.
YP_907372.1	membrane protein; this family of proteins contains the Mce (mycobacterial cell entry) proteins from mycobacterium tuberculosis. the archetype (Rv0169), was isolated as being necessary for colonisation of, and survival within, the macrophage. this family contains proteins of unknown function from other bacteria.
YP_907373.1	cytoplasmic protein
YP_907374.1	secreted protein
YP_907375.1	secreted protein
YP_907376.1	secreted protein
YP_907377.1	cytoplasmic protein; function unknown but domain identity suggests PlsC, phosphate acyltransferase. these enzymes function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2- acylglycerolphosphoethanolamine acyltransferase activities.
YP_907378.1	membrane protein
YP_907379.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_907380.1	Detected in the cytoplasmic and membrane fractiond and in the secreted proteins by 2D-LC-MS/MS.; cytoplasmic protein; putative antioxidant protein.
YP_907381.1	cytoplasmic protein; deacetylates acetylornithine and hydrolyses N- acetylmethionine.
YP_907382.1	cytoplasmic protein; regulator part of the two component regulatory system.
YP_907383.1	Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids
YP_907384.1	Detected in the membrane fraction by proteomics (LC- MS/MS) Also detected in the cytoplasm.; membrane protein; involved in lipid metabolism. fatty acid synthase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH
YP_907385.1	secreted protein
YP_907386.1	may act to bind either a ubiquinol or plastoquinol anion, transferring an electron to the 2Fe-2S cluster, then releasing the electron to a cytochrome C or cytochrome F haem iron.
YP_907387.1	cytoplasmic protein; function unknown role in lipid metabolism; contains a thioesterase/thiol ester dehydratase-isomerase superfamily domain
YP_907388.1	cytoplasmic protein; function unknown but like d/s ORF it contains a thioesterase/thiol ester dehydrase-isomerase superfmaily domain.
YP_907389.1	Also detected in the extracellular matrix by proteomics.; cytoplasmic protein
YP_907390.1	membrane protein; function unknown, possibly involved in transport of drug across the membrane. contains AraJ, arabinose efflux permease domain identity.
YP_907391.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_907392.1	cytoplasmic protein; function unknown but acetyl-CoA synthetase-like superfamily domain detected.
YP_907393.1	cytoplasmic protein; function unknown, probably involved in cellular metabolism. contains domain identity to phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases.
YP_907394.1	cytoplasmic protein; ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.
YP_907395.1	cytoplasmic protein; involved in transcriptional mechanism.
YP_907396.1	cytoplasmic protein; required for the transposition of the insertion element IS2606.
YP_907397.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_907398.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_907399.1	cytoplasmic protein
YP_907400.1	cytoplasmic protein; function unknown, but involved in lipid degradation.
YP_907401.1	cytoplasmic protein; function unknown, but supposed involvement in lipid degradation.
YP_907402.1	cytoplasmic protein; function unknown role in lipid metabolism
YP_907403.1	cytoplasmic protein; function unknown, but involved in lipid degradation.
YP_907404.1	secreted protein
YP_907405.1	membrane protein; function unknown but contains a ricin-type beta- trefoil domain.
YP_907406.1	cytoplasmic protein; function unknown. possibly involved in transcriptional mechanism.
YP_907407.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS; cytoplasmic protein
YP_907408.1	cytoplasmic protein; may be involved in regulation of SigG
YP_907409.1	cytoplasmic protein; function unknown, but involved in lipid degradation.
YP_907411.1	cytoplasmic protein
YP_907412.1	cytoplasmic protein; cytochromes P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
YP_907413.1	cytoplasmic protein; thought to catalyze the reversible oxidation of ethanol to acetaldehyde with the concomitant reduction of NAD. probably acts on primary or secondary alcohols or hemiacetals [catalytic activity: an alcohol + NAD+ = an aldehyde or ketone + NADH]
YP_907414.1	cytoplasmic protein; function unknown, probably involved in cellular metabolism.
YP_907415.1	cytoplasmic protein; cytochromes P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
YP_907416.1	cytoplasmic protein; key enzyme in the catabolic pathway of odd-chain fatty acids, isoleucine, threonine, methionine, and valine [catalytic activity: ATP + propionyl-CoA + CO(2) + H(2)O = ADP + orthophosphate + methylmalonyl-CoA]
YP_907417.1	May not be functional. C-term of the dehydrogenase section missing 40 aa. may be site of DNA deletion, resulting in a translation fusion with a d/s ORF . C-term contains full length of an uncharacterized homolog of a gamma-carboxymuconolactone decarboxylase subunit; membrane protein
YP_907418.1	cytoplasmic protein; function unknown, probably involved in cellular metabolism.
YP_907419.1	cytoplasmic protein; function unknown but contains a Ntf2-like superfmaily domain
YP_907420.1	secreted protein
YP_907421.1	cytoplasmic protein; function unknown but contains thioesterase/thiol ester dehydrase-isomerase superfmaily domain
YP_907422.1	activates fatty acids by binding to coenzyme A; in Mycobacterium may be involved in virulence
YP_907423.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_907424.1	cytoplasmic protein; cytochromes P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
YP_907425.1	cytoplasmic protein
YP_907426.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; function unknown, but involved in lipid degradation.
YP_907427.1	cytoplasmic protein
YP_907428.1	cytoplasmic protein
YP_907429.1	Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA
YP_907430.1	cytoplasmic protein
YP_907431.1	cytoplasmic protein
YP_907432.1	cytoplasmic protein; involved in transcriptional mechanism
YP_907433.1	cytoplasmic protein; oxidizes fatty acids using specific components [catalytic activity: (3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H(2)O]
YP_907434.1	cytoplasmic protein
YP_907435.1	cytoplasmic protein; oxidizes fatty acids using specific components (by similarity) [catalytic activity: (3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H(2)O]
YP_907436.1	cytoplasmic protein; oxidizes fatty acids using specific components [catalytic activity: (3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H(2)O]
YP_907437.1	cytoplasmic protein; oxidizes fatty acids using specific components [catalytic activity: (3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H(2)O]
YP_907438.1	cytoplasmic protein; function unknown, but supposed involvement in lipid degradation.
YP_907439.1	secreted protein
YP_907440.1	cytoplasmic protein; possibly involved in transcriptional mechanism.
YP_907441.1	cytoplasmic protein; function unknown, but involved in lipid degradation.
YP_907442.1	function unknown, but supposed involvement in lipid degradation.
YP_907443.1	Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis
YP_907444.1	membrane protein; thought to be involved in active transport of drugs across the membrane (export): multidrugs resistance by an export mechanism. responsible for energy coupling to the transport system and for the translocation of the substrate across the membrane.
YP_907445.1	membrane protein; thought to be involved in active transport of drugs across the membrane (export): multidrugs resistance by an export mechanism. responsible for energy coupling to the transport system and for the translocation of the substrate across the membrane.
YP_907446.1	membrane protein
YP_907447.1	membrane protein
YP_907448.1	HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine
YP_907449.1	membrane protein
YP_907450.1	RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs
YP_907451.1	cytoplasmic protein
YP_907452.1	cytoplasmic protein
YP_907453.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_907454.1	cytoplasmic protein; involved in energy metabolism; contributes to acetyl-CoA production as part of pyruvate dehydrogenase complex [catalytic activity: pyruvate + lipoamide = S- acetyl-dihydro-lipoamide + CO(2)]
YP_907455.1	cytoplasmic protein; involved in transcriptional mechanism.
YP_907456.1	secreted protein
YP_907457.1	membrane protein
YP_907458.1	membrane protein
YP_907459.1	membrane protein; function unknown, but thought to be involved in host cell invasion.
YP_907460.1	membrane protein; function unknown, but thought to be involved in host cell invasion.
YP_907461.1	membrane protein; function unknown, but thought to be involved in host cell invasion.
YP_907462.1	membrane protein; function unknown, but thought to be involved in host cell invasion.
YP_907463.1	membrane protein; function unknown, but thought to be involved in host cell invasion.
YP_907464.1	membrane protein; function unknown, but thought involved in host cell invasion.
YP_907465.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_907466.1	converts L-glutamate to D-glutamate, a component of peptidoglycan
YP_907467.1	secreted protein
YP_907468.1	cytoplasmic protein; function unknown but domain identity suggests this CDS encodes a metal-dependent protease of the Pad1/Jab1 superfamily.
YP_907469.1	membrane protein; function unknown, probable role in amino acid hydrolysis
YP_907470.1	cytoplasmic protein
YP_907471.1	cytoplasmic protein; function unknown but contains a ClpS domain suggesting a function related to ATP-dependent protein degradation.
YP_907472.1	catalyzes the formation of 5-phospho-alpha-D-ribose 1-diphosphate and nicotinate from nicotinate D-ribonucleotide and diphosphate
YP_907473.1	cytoplasmic protein; probable helicase involved in DNA repair and perhaps also replication.
YP_907474.1	cytoplasmic protein; catalytic activity : {(1,4)-alpha-D-glucosyl}(N) + phosphate = {(1,4)-alpha-D-glucosyl}(N-1) + alpha-D- glucose 1-phosphate.
YP_907475.1	also detected in the membrane fraction by proteomics (LC-MS/MS); cytoplasmic protein; function unknown, may be involved in polysaccharide degradation.
YP_907476.1	catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain
YP_907477.1	Also detected in the extracellular matrix and secreted fraction by proteomics.; extracellular matrix protein; thioredoxin participates in various redox reactions through the reversible oxidation of its active center dithiol, to a disulfide, & catalyzes dithiol-disulfide exchange reactions
YP_907478.1	Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; in Rhizobia and Ralstonia is involved in PHB biosynthesis
YP_907479.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; glyoxalase I (lactoylglutathione lyase) catalyzes the first step of the glyoxal pathway.
YP_907480.1	cytoplasmic protein; function unknown but contains a predicted nuclease domain of the RecB family
YP_907481.1	cytoplasmic protein; required for the transposition of the insertion element IS2606.
YP_907482.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_907483.1	membrane protein; thought to play a role in regulation of cellular metabolism by catalysing the synthesis of a second messenger, camp [catalytic activity: ATP = 3',5'-cyclic AMP + pyrophosphate]
YP_907484.1	cytoplasmic protein; involved in damage reversal and in base excision repair. the methylated Ada protein acts as a positive regulator of its own synthesis, as well as that of other proteins. the transcription-activating function of the Ada protein resides in its N-terminus. repair of alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. this is a suicide reaction: the enzyme is irreversibly inactivated. can also repair O-4- methylthymine [catalytic activity: DNA (containing 6-O- methylguanine) + [protein]-L-cysteine = DNA (without 6-O- methylguanine) + protein S-methyl-L-cysteine]
YP_907485.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS. Also detected in the membrane fraction by proteomics (2D-LC-MS/MS); cytoplasmic protein; repair of alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. this is a suicide reaction: the enzyme is irreversibly inactivated [catalytic activity : DNA (containing 6-O-methylguanine) + [protein]-L-cysteine = DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine]
YP_907486.1	adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active
YP_907487.1	Detected in the cytoplamic fraction by LC-MS/MS. Also detected in the membrane fraction by proteomics (2D- LC-MS/MS); membrane protein; these proteins convert inactive cobalamins to AdoCbl for 1,2-propanediol degradation.
YP_907488.1	cytoplasmic protein
YP_907489.1	part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane
YP_907490.1	Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit
YP_907491.1	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit
YP_907492.1	produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit
YP_907493.1	produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex
YP_907494.1	Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel.
YP_907495.1	Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0
YP_907496.1	Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0
YP_907497.1	membrane protein
YP_907498.1	membrane protein; catalysis of the first step of the lipid cycle reactions in the biosynthesis of cell wall peptidoglycan.
YP_907499.1	function unknown but contains YrdC domain. this domain has been shown to preferentially bind to dsRNA.
YP_907500.1	cytoplasmic protein; function unknown but may have S-adenosyl-methionine- dependent methyltransferase activity.
YP_907501.1	recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2
YP_907502.1	RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome
YP_907503.1	An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes
YP_907504.1	catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate
YP_907505.1	catalyzes the formation of L-threonine from O-phospho-L-homoserine
YP_907506.1	catalyzes the formation of L-aspartate 4-semialdehyde from L-homoserine
YP_907507.1	cytoplasmic protein; involved in biosynthesis of lysine (last step) [catalytic activity : meso-2,6-diaminoheptanedioate = L- lysine + CO(2)]
YP_907508.1	catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase
YP_907509.1	cytoplasmic protein
YP_907510.1	membrane protein
YP_907511.1	cytoplasmic protein; this family of dehydrogenases act on aldehyde substrates. members use NADP as a cofactor.
YP_907512.1	cytoplasmic protein; pyridoxamine 5'-phosphate oxidase is a FMN flavoprotein involved in the de novo synthesis of pyridoxine (vitamin B6) and pyridoxal phosphate.
YP_907513.1	cytoplasmic protein; function unknown but contains YCII-related protein domain
YP_907514.1	catalyzes the cleavage of carbon-halogen bonds in aliphatic compounds forming a primary alcohol and a halide
YP_907515.1	cytoplasmic protein; cleaves xaa-pro-releasing N-terminal dipeptides.
YP_907516.1	cytoplasmic protein; function unknown but belongs to the TetR family of bacterial transcriptional regulatory proteins.
YP_907517.1	membrane protein
YP_907518.1	cytoplasmic protein; function unknown, belongs to the LysR family of transcriptional regulators
YP_907519.1	membrane protein; function unknown role in transport. belongs to the DMT superfamily.
YP_907520.1	membrane protein
YP_907521.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; thought to play a role in regulation of cellular metabolism by catalysing the synthesis of a second messenger, camp [catalytic activity: ATP = 3',5'-cyclic AMP + pyrophosphate]
YP_907522.1	secreted protein
YP_907523.1	membrane protein
YP_907524.1	cytoplasmic protein; function unknown, probably involved in cellular metabolism.
YP_907525.1	cytoplasmic protein; catalyzes the first step of the glyoxal pathway
YP_907526.1	cytoplasmic protein; function unknown but contains glyoxalase/bleomycin resistance protein/Dihydroxybiphenyl dioxygenase superfamily domain.
YP_907527.1	cytoplasmic protein
YP_907528.1	in Rhizobium meliloti this protein is involved in the synthesis of nodulation factors that are active on the roots of alfalfa; catalyzes formation of activated sulfate intermediate; converts ATP and sulfate to diphosphate and adenylylsulfate and then ATP and adenylyl sulfate to ADP and 3'-phosphoadenylyl sulfate; the activated intermediate is transferred to the nodulation factors by NodH; may interact with NodP and NodQ; similar to the CysD and CysN proteins from EScherichia coli involved in cysteine biosynthesis
YP_907529.1	with CysN catalyzes the formation of adenylylsulfate from sulfate and ATP
YP_907530.1	cytoplasmic protein; function unknown, contains a thioesterase superfamily domain
YP_907531.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS. Also detected in the extracellular matrix and membrane fraction by proteomics.; membrane protein; domain identity to carbonic anhydrases. these are zinc metalloenzymes which catalyze the reversible hydration of carbon dioxide.
YP_907532.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; involved in active transport of oligopeptide across the membrane (import) responsible for the translocation of the substrate across the membrane.
YP_907533.1	membrane protein; involved in active transport of oligopeptide across the membrane (import) responsible for the translocation of the substrate across the membrane.
YP_907534.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; involved in active transport of oligopeptide across the membrane (import) responsible for energy coupling to the transport system.
YP_907535.1	Also detected in the cytoplasm.; membrane protein; involved in active transport of oligopeptide across the membrane (import) this protein is a component of the oligopeptide permease, a binding protein-dependent transport system; it binds peptides up to five amino acids long with high affinity.
YP_907536.1	cytoplasmic protein; function unknown, probably involved in cellular metabolism, probably electron-transfer-linked.
YP_907537.1	Detected in the cytoplamic fraction by LCMSMS; cytoplasmic protein; function unknown, contains P-loop containing nucleoside triphosphate hydrolase superfamily domain
YP_907538.1	cytoplasmic protein; function unknown: possible role in DNA replication, recombination, and repair.
YP_907539.1	cytoplasmic protein; function unknown, possible role in signal transduction
YP_907540.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_907541.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_907542.1	membrane protein; thought to be involved in active transport of drugs across the membrane (export): multidrugs resistance by an export mechanism. responsible for energy coupling to the transport system and for the translocation of the substrate across the membrane.
YP_907543.1	membrane protein; thought to be involved in active transport of drugs across the membrane (export): multidrugs resistance by an export mechanism. responsible for energy coupling to the transport system and for the translocation of the substrate across the membrane.
YP_907544.1	secreted protein
YP_907545.1	secreted protein
YP_907546.1	membrane protein
YP_907547.1	secreted protein
YP_907548.1	secreted protein
YP_907549.1	cytoplasmic protein; involved in transcriptional mechanism. thought to regulate the biosynthesis of the mycobacterial cell wall arabinan and resistance to ethambutol (Emb; dextro-2,2'- (ethylenediimino)-di-1-butanol), regulating EmbA and EmbB.
YP_907550.1	cytoplasmic protein
YP_907551.1	Detected in the cytoplasmic fraction by LC-MS/MS. Also detected in the extracellular matrix and membrane fraction by proteomics.; cytoplasmic protein; interconversion of acetate and oxaloacetate from citrate [catalytic activity: citrate = acetate + oxaloacetate]
YP_907552.1	Detected in the cytoplasmic fraction by LC-MS/MS. Also detected in the membrane fraction by proteomics (2D- LC-MS/MS); cytoplasmic protein
YP_907553.1	Detected in the membrane fraction by proteomics (LC- MS/MS) Also detected in the cytoplamic fraction by LCMSMS; membrane protein; could be implicated in several pathways involving acetyl-CoA. E.G. acetyl-CoA hydrolase from yeast catalyses the formation of acetate from acetyl-CoA, CoA transferase (CAT1) produces succinyl-CoA, and acetate-CoA transferase utilizes  acyl-CoA and acetate to form acetyl-CoA.
YP_907554.1	Detected in the cytoplasmic and membrane fractionc by proteomics.; cytoplasmic protein; function unknown, but involved in lipid degradation.
YP_907555.1	membrane protein; hydrolyses glycerophosphodiesters such as glycerophosphocholine, glycerophosphoethanolamine, glycerophosphoglycerol, and bis(glycerophosphoglycerol)
YP_907556.1	cytoplasmic protein
YP_907557.1	secreted protein
YP_907558.1	cytoplasmic protein; glyoxalase I (lactoylglutathione lyase) catalyzes the first step of the glyoxal pathway.
YP_907559.1	cytoplasmic protein; required for the transposition of the insertion element IS2606.
YP_907560.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_907561.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_907562.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_907563.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; possibly involved in the uptake of malate and other dicarboxylates by a proton symport mechanism. in E. coli, this protein has been implicated in resistance to tellurite.
YP_907564.1	secreted protein
YP_907565.1	membrane protein
YP_907566.1	membrane protein; function unknown but contains a cell envelope- related transcriptional attenuator domain. CpsA is a domain of unknown function that is found in the predicted extracellular domain of a number of putative membrane- bound proteins. may play a role in regulation of transcription.
YP_907567.1	cytoplasmic protein; function unknown, probably involved in cellular metabolism
YP_907568.1	cytoplasmic protein; function unknown, supposed to be involved in cellular metabolism.
YP_907569.1	cytoplasmic protein; probable role in the biosynthesis of the product from U/S PKS gene, carrying its acyl intermediates.
YP_907570.1	activates fatty acids by binding to coenzyme A
YP_907571.1	cytoplasmic protein; could be involved in biotin biosynthesis (at the first step) [catalytic activity: 6-carboxyhexanoyl-CoA + L- alanine = 8-amino-7-oxononanoate + CoA + CO2]
YP_907572.1	membrane protein; function unknown but domain identity suggests permease component of an uncharacterized ABC-type transport system.
YP_907573.1	membrane protein; involved in active transport of inorganic phosphate across the membrane (import); responsible for energy coupling to the transport system. this is one of the proteins required for binding-protein-mediated phosphate transport. have ATP-binding ability and ATPase activity.
YP_907574.1	cytoplasmic protein; members of the PadR-like family are transcriptional regulators that appear to be related to the pfam01047 family. this family includes PadR, a protein that is involved in negative regulation of phenolic acid metabolism.
YP_907575.1	cytoplasmic protein
YP_907576.1	cytoplasmic protein; involved in osmoregulatory trehalose biosynthesis. mycobacteria can produce trehalose from glucose 6- phosphate and UDP-glucose (the OtsA-OtsB pathway) from glycogen-like alpha(1-->4)-linked glucose polymers (the TreY-TreZ pathway) and from maltose (the TreS pathway) [catalytic activity: trehalose 6-phosphate + H(2)O = trehalose + orthophosphate]
YP_907577.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_907578.1	membrane protein
YP_907579.1	membrane protein; function unknown, but thought involved in host cell invasion.
YP_907580.1	secreted protein; function unknown, but thought to be involved in host cell invasion.
YP_907581.1	membrane protein; function unknown, but thought to be involved in host cell invasion.
YP_907582.1	membrane protein; function unknown, but thought to be involved in host cell invasion.
YP_907583.1	membrane protein; function unknown, but thought to be involved in host cell invasion.
YP_907584.1	membrane protein; function unknown, but thought to be involved in host cell invasion.
YP_907585.1	membrane protein
YP_907586.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_907587.1	Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis
YP_907588.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS. Also detected in the secreted fraction by proteomics.; cytoplasmic protein; ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.
YP_907589.1	Detected in the membrane fraction by proteomics.; membrane protein; function unknown, but involved in lipid degradation.
YP_907590.1	cytoplasmic protein; function unknown, but involved in lipid degradation.
YP_907591.1	activates fatty acids by binding to coenzyme A
YP_907592.1	function unknown but contains beta- lactamase/transpeptidase-like superfamily domain
YP_907593.1	thiamine-pyrophosphate requiring enzyme
YP_907594.1	cytoplasmic protein
YP_907595.1	activates fatty acids by binding to coenzyme A; in Mycobacterium may be involved in virulence
YP_907596.1	Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA
YP_907597.1	cytoplasmic protein; cytochromes P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
YP_907598.1	cytoplasmic protein
YP_907599.1	cytoplasmic protein; function unknown, probably involved in cellular metabolism.
YP_907600.1	cytoplasmic protein; function unknown, contains a C-term predicted nucleic-acid-binding domain
YP_907601.1	cytoplasmic protein; function unknown, probably involved in lipid metabolism.
YP_907602.1	Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation
YP_907603.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; function unknown, probably involved in cellular metabolism.
YP_907604.1	cytoplasmic protein; function unknown, this class of proteins is involved in enzymatic cleavage of a C-H bond adjacent to carbonyl or a carboxyl group, leading to an enol or a enolate intermediate that is subsequently re-protonated at the same or an adjacent carbon.
YP_907605.1	cytoplasmic protein; function unknown, contains carbonic anhydrases/acetyltransferase superfamily domain
YP_907606.1	cytoplasmic protein; function unknown, probably involved in cellular metabolism.
YP_907607.1	cytoplasmic protein
YP_907608.1	cytoplasmic protein; function unknown, contains P-loop containing nucleoside triphosphate hydrolase superfamily domain
YP_907609.1	cytoplasmic protein; function unknown, probably involved in cellular metabolism.
YP_907610.1	cytoplasmic protein
YP_907611.1	cytoplasmic protein; function unknown, this enzyme catalyses the first and rate limiting step in de novo glutathione biosynthesis.
YP_907612.1	catalyzes the formation of pyruvate and acetaldehyde from 4-hydroxy-2-ketovaleric acid; involved in the degradation of phenylpropionate
YP_907613.1	catalyzes the formation of acetyl-CoA from acetalaldehyde
YP_907614.1	cytoplasmic protein; function unknown, probably involved in cellular metabolism.
YP_907615.2	initiates steroid ring degradation; catalyzes the transhydrogenation of 3-keto-4-ene-steroid to 3-keto-1,4-diene-steroid e.g., progesterone to 1,4-androstadiene-3,17-dione
YP_907616.1	cytoplasmic protein; function unknown, probably involved in cellular metabolism.
YP_907617.1	cytoplasmic protein; function unknown, contains restriction endonuclease- like superfamily domain
YP_907618.1	cytoplasmic protein; function unknown, supposed involvement in lipid metabolism.
YP_907619.1	cytoplasmic protein; function unknown, potential role in lipid metabolism. contains thioesterase/thiol ester dehydrase- isomerase superfamily domain.
YP_907620.1	cytoplasmic protein; function unknown, contains a predicted C-term nucleic-acid-binding protein
YP_907621.1	Detected in the cytoplasmic fraction by proteomics.; cytoplasmic protein; function unknown, but involved in lipid degradation.
YP_907622.1	cytoplasmic protein; function unknown, but involved in lipid degradation.
YP_907623.1	cytoplasmic protein; cytochromes P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
YP_907624.1	Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation
YP_907625.1	cytoplasmic protein; function unknown, contains a FMN-binding split barrel domain. possible role in the electron-transfer pathway. the FMN-binding split barrel is related to the ferredoxin reductase-like FAD-binding domain. flavodoxins are an example of a group of proteins with a tightly bound flavin mononucleotide (FMN) that mediate electron transfer at low redox potential.
YP_907626.1	cytoplasmic protein; function unknown, supposed involvement in cellular metabolism.
YP_907627.1	cytoplasmic protein; function unknown, supposed involvement in cellular metabolism.
YP_907628.1	Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA
YP_907629.1	cytoplasmic protein; function unknown. possible subunit of a CoA- transferase, catalyzing the reversible of CoA from one carboxylic acid to another.
YP_907630.1	cytoplasmic protein; function unknown. possible subunit of a CoA- transferase, catalyzing the reversible of CoA from one carboxylic acid to another.
YP_907631.1	cytoplasmic protein; function unknown, members of this family catalyse the denitrification of a number of nitroalkanes using either fad or FMN as a cofactor.
YP_907632.1	membrane protein; function unknown, c-terminus probably involved in electron transfer in one or several metabolic reactions.
YP_907633.1	Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation
YP_907634.1	cytoplasmic protein; involved in transcriptional mechanism.
YP_907635.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_907636.1	cytoplasmic protein; function unknown, probably involved in cellular metabolism.
YP_907637.1	cytoplasmic protein; function unknown, but involved in lipid degradation.
YP_907638.1	activates fatty acids by binding to coenzyme A
YP_907639.1	cytoplasmic protein; function unknown, but involved in lipid degradation.
YP_907640.1	cytoplasmic protein; function unknown, but involved in lipid degradation.
YP_907641.1	cytoplasmic protein; function unknown, but involved in lipid degradation.
YP_907642.1	catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate
YP_907643.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; could have a role in acetylating, and hence inactivating, the antitubercular drug isoniazid [catalytic activity: acetyl-CoA + arylamine = CoA + N- acetylarylamine]
YP_907644.1	cytoplasmic protein; function unknown.
YP_907645.1	Detected in the secreted fraction by proteomics.; secreted protein; function unknown, possibly involved in thiol:disulfide interchange.  contains PS00013 prokaryotic membrane lipoprotein lipid attachment site, N-term signal pepitde sequence and PS00194 thioredoxin family active site.
YP_907646.1	membrane protein; function unknown, but domain identity suggests this protein may have metalloendopeptidase activity.
YP_907647.1	cytoplasmic protein; involved in transcriptional mechanism.
YP_907648.1	secreted protein
YP_907649.1	cytoplasmic protein; function unknown, probably involved in cellular metabolism.
YP_907650.1	cytoplasmic protein; involved in the degradation of biphenyl [catalytic activity: biphenyl-2,3-diol + O(2) = 2-hydroxy-6-oxo-6- phenylhexa-2,4-dienoate + H(2)O]
YP_907651.1	cytoplasmic protein; involved in the degradation of biphenyl.
YP_907652.1	cytoplasmic protein; function unknown, probably involved in cellular metabolism.
YP_907653.1	cytoplasmic protein; may play a role in protection from oxidative (nitric oxide) and nitrosative stress. may also be involved in anaerobic metabolism. could have nitric oxide dioxygenase activity.
YP_907654.1	secreted protein
YP_907655.1	cytoplasmic protein; function unknown, but involved in lipid degradation.
YP_907656.1	cytoplasmic protein; involved in transcriptional mechanism.
YP_907657.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; involved in transcriptional mechanism.
YP_907658.1	membrane protein; function unknown, domain identity suggests periplasmic solute binding protein, containing an ATP- binding cassette transport system
YP_907659.1	membrane protein; function unknown, part of a binding-protein- dependent ABC transport system
YP_907660.1	membrane protein; part of an ABC transport system
YP_907661.1	secreted protein
YP_907662.1	membrane protein
YP_907663.1	cytoplasmic protein; function unknown, the lam locus of aspergillus nidulans consists of two divergently transcribed genes, lama and Lamb, involved in the utilization of lactams such as 2-pyrrolidinone. both genes are under the control of the positive regulatory gene AmdR and are subject to carbon and nitrogen metabolite repression. the exact molecular function of the proteins in this family is unknown.
YP_907664.1	cytoplasmic protein
YP_907665.1	membrane protein; thought to be involved in transport of arsenic across the membrane (export): arsenic resistance by an export mechanism. form the channel of an arsenite pump responsible for the translocation of the substrate across the membrane.
YP_907666.1	Detected in the membrane fraction by proteomics.; cytoplasmic protein; function unknown role in tRNA and rRNA base modification by methylation.
YP_907667.1	catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA
YP_907668.1	catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate
YP_907669.1	4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers
YP_907670.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; function unknown role in regulation
YP_907671.1	membrane protein
YP_907672.1	non-specific DNA-binding; scans chromosomes during sporulation for DNA-damage; delays initiation of sporulation; participates in a checkpoint signaling cascade for cell-cycle progression and DNA repair
YP_907673.1	Detected in the membrane fraction by proteomics (LC- MS/MS) Also detected in the secreted protein fraction; membrane protein
YP_907674.1	cytoplasmic protein; catalyzes the reversible hydratation of carbon dioxide [catalytic activity: H(2)CO(3) = CO(2) + H(2)O]
YP_907675.1	cytoplasmic protein; involved in base excision repair. removes adenine mispaired with 8-OXOG. may repair a.G and a.C mismatches by adenine excision.
YP_907676.1	cytoplasmic protein; function unknown, probably involved in cellular metabolism.
YP_907677.1	membrane protein
YP_907678.1	cytoplasmic protein; transfers mannose from GDP-mannose to all endogenous polyprenol-phosphates.
YP_907679.1	membrane protein; thought to be involved in a transport system across the membrane (perhaps drug transport): responsible for the translocation of the substrate across the membrane.
YP_907680.1	cytoplasmic protein; may be involved in the catalysis of both the synthesis and the degradation of fructose-2,6- bisphosphate. beta-D-fructose 2,6-bisphosphate + H(2)O <=> D-fructose 6-phosphate +  phosphate.
YP_907681.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_907682.1	membrane protein
YP_907683.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_907684.1	Also detected in the extracellular matrix by proteomics.; cytoplasmic protein; hydrolyses proteins in presence of ATP. may interact with a ClpP-like protease involved in degradation of denatured proteins.
YP_907685.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_907686.1	Detected in the cytoplasmic and the extracellular matrix fractions by proteomics.; extracellular matrix protein; dominant T-cell antigen and may stimulate lymphocyte proliferation.
YP_907687.1	class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1
YP_907688.1	type III; catalyzes the formation of (R)-4'-phosphopantothenate from (R)-pantothenate in coenzyme A biosynthesis; type III pantothenate kinases are not subject to feedback inhibition from coenzyme A and have a high Km for ATP
YP_907689.1	Converts L-aspartate to beta-alanine and provides the major route of beta-alanine production in bacteria. Beta-alanine is essential for the biosynthesis of pantothenate (vitamin B5)
YP_907690.1	catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine
YP_907691.1	function unknown contains NAD(P)-binding Rossmann- fold superfamily domains
YP_907692.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_907693.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_907694.1	cytoplasmic protein; involved in dihydrofolate biosynthesis (at the first step) [catalytic activity: ATP + 2-amino-4-hydroxy-6- hydroxymethyl-7,8-dihydropteridine = AMP + 2-amino-7,8- dihydro-4-hydroxy-6-(diphosphooxymethyl)pteri di ne]
YP_907695.1	cytoplasmic protein; involved in folate biosynthesis. catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8- dihydropterin (by similarity) [catalytic activity: 2-amino- 4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7, 8- dihydropteridine = 2-amino-4-hydroxy-6-hydroxymethyl-7,8- dihydropteridine + glycolaldehyde]
YP_907696.1	cytoplasmic protein; involved in dihydrofolate biosynthesis (at the second step) catalyzes the formation of the immediate precursor of folic acid. it is implicated in resistance to sulfonamide [catalytic activity: 2-amino-4-hydroxy-6- hydroxymethyl-7,8-dihydropteridine diphosphate + 4- aminobenzoate = pyrophosphate + dihydropteroate]
YP_907697.1	involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer
YP_907698.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS. Also detected in the membrane fraction by proteomics (LC-MS/MS); membrane protein; thought to act as an ATP-dependent zinc metallopeptidase, with ATPase and proteolytic activities. probably has a regulatory role in stress response and specific proteins secretion for adaptation to host environment.
YP_907699.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; biotransformation enzyme that catalyzes the hydrolysis of epoxides (alkene oxides, oxiranes) and Arene oxides to less reactive and more water soluble dihydrodiols by the trans addition of water. thought to be involved in detoxification reactions following oxidative damage to lipids [catalytic activity: an epoxide + H(2)O = a glycol]
YP_907700.1	potential pseudogene as C-term extension caused by removal of stop codon and additional 170 aa added.; cytoplasmic protein
YP_907701.1	PPE65; membrane protein
YP_907702.1	PE32; membrane protein
YP_907703.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_907704.1	membrane protein
YP_907705.1	cytoplasmic protein; involved in purine salvage [catalytic activity: imp + pyrophosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate (guanine can replace hypoxanthine to produce GMP)]
YP_907706.1	cytoplasmic protein; predicted ATPase of the PP-loop superfamily implicated in cell cycle control
YP_907707.1	cytoplasmic protein
YP_907708.1	membrane protein; involved in peptidoglycan synthesis (at final stages) hydrolyzes the bound D-alanyl-D-alanine [catalytic activity: D-alanyl-D-alanine + H(2)O = 2 D- alanine]
YP_907709.1	Also detected in the extracellular matrix by proteomics.; cytoplasmic protein; involved in the function of cellular bioenergetics [catalytic activity: pyrophosphate + H(2)O = 2 orthophosphate]
YP_907710.1	membrane protein
YP_907711.1	cytoplasmic protein; required for the transposition of the insertion element IS2606.
YP_907712.1	membrane protein
YP_907713.1	cytoplasmic protein; function unknown, the domain detected in this CDS is found in a diverse family of glycosyl transferases that transfer the sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.
YP_907714.1	membrane protein
YP_907715.1	cytoplasmic protein; involved in galactofuranosyl biosynthesis: converts UDO-GlcP to UDP-GalP [catalytic activity: UDP- glucopyranose = UDP-galactopyranose]
YP_907716.1	membrane protein
YP_907717.1	cytoplasmic protein
YP_907718.1	cytoplasmic protein; required for the transposition of the insertion element IS2606.
YP_907719.1	cytoplasmic protein
YP_907720.1	cytoplasmic protein
YP_907721.1	cytoplasmic protein
YP_907722.1	catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA
YP_907723.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; C-term contains an adenylyl/guanylyl cyclase domain. may catalyze the formation of cyclic AMP/GMP from ATP/GTP.
YP_907724.1	catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity
YP_907725.1	cytoplasmic protein
YP_907726.1	Detected in the cytoplamic and the secreted fractions by proteomics.; cytoplasmic protein; possibly involved in cold acclimatization processes (the production of the protein is supposed predominantly induced at low temperatures)
YP_907727.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein
YP_907728.1	cytoplasmic protein
YP_907729.1	membrane protein
YP_907730.1	membrane protein
YP_907731.1	membrane protein; function unknown, contains domain identity to Flp pilus assembly protein TadB
YP_907732.1	cytoplasmic protein; function unknown, contains domain identity with Flp pilus assembly protein, ATPase CpaF
YP_907733.1	cytoplasmic protein; function unknown, has a P-loop containing nucleoside triphosphate hydrolase superfamily domain.
YP_907734.1	membrane protein; phosphoserine + H(2)O <=> serine + phosphate
YP_907735.1	cytoplasmic protein
YP_907736.1	cytoplasmic protein
YP_907737.1	membrane protein; involved in active transport of dipeptides across the membrane (import) responsible for energy coupling to the transport system.
YP_907738.1	membrane protein; involved in active transport of dipeptide across the membrane (import) responsible for the translocation of the substrate across the membrane.
YP_907739.1	membrane protein; involved in active transport of dipeptide across the membrane (import) responsible for the translocation of the substrate across the membrane.
YP_907740.1	membrane protein; thought to be involved in active transport of dipeptide across the membrane (import)
YP_907741.1	Acs; catalyzes the conversion of acetate and CoA to acetyl-CoA
YP_907742.1	membrane protein; function unknown, domain identity suggests peptidase, trypsin-like serine or cysteine protease. contains peptidase S1B, active site.
YP_907743.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_907744.1	thought to be involved in detoxification reactions following oxidative damage to lipids. biotransformation enzyme that catalyzes the hydrolysis of epoxides: aromatic hydrocarbons catabolism [catalytic activity: an epoxide + H(2)O = a glycol]
YP_907745.1	membrane protein; function unknown, hydrolyses of peptides and/or proteins (possibly cleaved preferentially after serine residue) contains peptidase S1B, active site
YP_907746.1	membrane protein; function unknown, contains a N-term thioredoxin domain. may serve as a general protein disulphide oxidoreductase.
YP_907747.1	cytoplasmic protein; has both an apurinic and/or apyrimidinic endonuclease activity and a DNA N-glycosylase activity. incises damaged DNA at cytosines, thymines and guanines. acts on a damaged strand (oxidized pyrimidines), 5' from the damaged site [catalytic activity: endonucleolytic cleavage near apurinic or apyrimidinic sites to products with 5'-phosphate]
YP_907748.1	membrane protein
YP_907749.1	Detected in the cytoplasmic and membrane fractions by proteomics.; cytoplasmic protein; involved in transcriptional mechanism.
YP_907750.1	cytoplasmic protein; function unknown, probably involved in cellular metabolism.
YP_907751.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; function unknown, this endoribonuclease domain is active on single-stranded mRNA and inhibits protein synthesis by cleavage of mRNA.
YP_907753.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; membrane protein; function unknown, may catalyze the extrusion of undeterminated anions [catalytic activity: ATP + H(2)O + undeterminated anion(in) = ADP + phosphate + undeterminated anion(out)]
YP_907754.1	membrane protein; anion-transporting ATPase; supposed catalyzes the extrusion of undeterminated anions [catalytic activity: ATP + H(2)O + undeterminated anion(in) = ADP + phosphate + undeterminated anion(out)]
YP_907755.1	potential pseudogene as N-term truncated due to mutation of original start codon; cytoplasmic protein; involved in a transcriptional mechanism.
YP_907756.1	membrane protein; involved in peptidoglycan synthesis (at the final stages), cell wall formation. synthesis of cross-linked peptidoglycan from the lipid intermediates. the enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits)
YP_907757.1	Detected in the cytoplasmic and membrane fractions by proteomics; membrane protein; function unknown, contains metallophosphoesterase domain
YP_907758.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; function unknown, probably involved in cellular metabolism. reaction catalysed: O(3)-acetyl-L-serine + H(2)S <=> L-cysteine + acetate.
YP_907759.1	cytoplasmic protein
YP_907760.1	cytoplasmic protein
YP_907761.1	membrane protein
YP_907762.1	membrane protein; NrfD is an integral transmembrane protein with loops in both the periplasm and the cytoplasm. NrfD is thought to participate in the transfer of electrons, from the quinone pool into the terminal components of the Nrf pathway.
YP_907763.1	cytoplasmic protein; function unknown, contains GatB/Yqey domain. this domain is found at the C terminus of GatB which transamidates glu-tRNA to Gln-tRNA.
YP_907764.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_907765.1	cytoplasmic protein
YP_907766.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein
YP_907767.1	Detected in the cytoplasmic fraction by LC-MS/MS. Also detected in the extracellular matrix and membrane fraction by proteomics.; cytoplasmic protein; involved in transcriptional mechanism; regulates methanol dehydrogenase.
YP_907768.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; membrane protein; function unknown, contains N-term signal peptide
YP_907769.1	membrane protein
YP_907770.1	membrane protein; function unknown, contains RDD domain RDD family. the molecular function of this region is unknown. however this region may be involved in transport of an as yet unknown set of ligands.
YP_907771.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein
YP_907772.1	PE_PGRS9_2; membrane protein
YP_907773.1	Converts glycerol and ADP to glycerol-3-phosphate and ADP
YP_907774.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; probable role in the metabolism of proteins containing the rare amino acid selenocysteine
YP_907775.1	cytoplasmic protein
YP_907776.1	cytoplasmic protein; function unknown, contains N-terminal nucleophile aminohydrolase superfamily domain
YP_907777.1	cytoplasmic protein
YP_907778.1	secreted protein
YP_907779.1	Also detected in the membrane fraction by proteomics (LC-MS/MS); cytoplasmic protein; protects against oxidative stress. converts hydrogen peroxide to water and molecular oxygen.
YP_907780.1	cytoplasmic protein; function unknown, rich in short repeat motifs.
YP_907781.1	cytoplasmic protein; function unknown, rich in short repeat motifs.
YP_907782.1	secreted protein
YP_907783.1	catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde
YP_907784.1	catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP, in Bacillus, lysine sensitive; regulated by response to starvation.
YP_907785.1	cytoplasmic protein
YP_907786.1	cytoplasmic protein; involved in leucine biosynthesis (at the first step) catalyzes condensation of acetyl-CoA and 2- oxoisovalerate to form 2-isopropylmalate synthase [catalytic activity: 3-carboxy-3-hydroxy-4- methylpentanoate + CoA = acetyl-CoA + 3-methyl-2- oxobutanoate + H(2)O]
YP_907787.1	cytoplasmic protein; involved in transcriptional mechanism.
YP_907788.1	membrane protein; function unknown, contains multidrug efflux transporter AcrB transmembrane superfamily domain
YP_907789.1	3'-5' exonuclease of DNA polymerase III
YP_907790.1	membrane protein; possible role in cell wall peptidoglycan biogenesis. contains Mur ligase family catalytic domain. possible UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D- alanine ligase, required for the formation of the UDP- MurNAc-linked pentapeptide by addition of the D-Ala-D-Ala subgroup.
YP_907791.1	cytoplasmic protein; involved in cobalamin biosynthesis. catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic a,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (by similarity)
YP_907792.1	involved in a recombinational process of DNA repair, independent of the recBC complex
YP_907793.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein
YP_907794.1	membrane protein; hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain bacterial cell-wall glycopeptides.
YP_907795.1	Detected in the membrane fraction by proteomics (LC- MS/MS); cytoplasmic protein; function unknown, contains bet v1-like superfamily domain
YP_907796.1	cytoplasmic protein
YP_907797.1	membrane protein
YP_907798.1	cytoplasmic protein
YP_907799.1	cytoplasmic protein
YP_907800.1	catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA
YP_907801.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS. Also detected in the extracellular matrix and the membrane fractions by proteomics.; cytoplasmic protein
YP_907802.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_907803.1	Detected in the cytoplasmic fraction by proteomics; cytoplasmic protein; oxidizes fatty acids using specific components [catalytic activity: (3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H(2)O]
YP_907804.1	membrane protein
YP_907805.1	cytoplasmic protein
YP_907806.1	cytoplasmic protein
YP_907807.1	secreted protein; hydrolysis of cutin (a polyester that forms the structure of plant cuticle)
YP_907808.1	membrane protein; function unknown, probably involved in cellular metabolism.
YP_907809.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_907810.1	cytoplasmic protein
YP_907811.1	cytoplasmic protein
YP_907812.1	PE5_1; Detected in the membrane fraction by proteomics.; membrane protein
YP_907813.1	cytoplasmic protein
YP_907814.1	cytoplasmic protein
YP_907815.1	catalyzes the ATP-dependent formation of a phosphodiester at the site of a single-strand break in duplex DNA; in mycobacteria LigC has weak intrinsic nick joining activities and is not essential for growth
YP_907816.1	cytoplasmic protein
YP_907817.1	membrane protein
YP_907818.1	cytoplasmic protein
YP_907819.1	cytoplasmic protein; function unknown, involved in cellular metabolism
YP_907820.1	cytoplasmic protein
YP_907821.1	membrane protein
YP_907822.1	cytoplasmic protein; function unknown, but involved in lipid degradation.
YP_907823.1	cytoplasmic protein; involved in transcriptional mechanism.
YP_907824.1	membrane protein
YP_907825.1	Detected in the secreted fraction by proteomics.; secreted protein; function unknown role in oxidoreduction
YP_907826.1	cytoplasmic protein
YP_907827.1	cytoplasmic protein
YP_907828.1	cytoplasmic protein; involved at the first committed step in the 'phosphorylated' pathway of L-serine biosynthesis [catalytic activity: 3-phosphoglycerate + NAD(+) = 3- phosphohydroxypyruvate + NADH]
YP_907829.1	membrane protein; involved in lipid metabolism.
YP_907830.1	cytoplasmic protein; aminopeptidase with broad substrate specificity to several peptides (could preferentially cleave leucine, arginine and lysine in peptide-bond-containing substrates)
YP_907831.1	cytoplasmic protein
YP_907832.1	PE34; membrane protein
YP_907833.1	cytoplasmic protein
YP_907834.1	cytoplasmic protein; function unknown, supposed involvement in cellular metabolism.
YP_907835.1	cytoplasmic protein; function unknown, probably involved in cellular metabolism.
YP_907836.1	cytoplasmic protein
YP_907837.1	membrane protein
YP_907838.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; unknwon
YP_907839.1	cytoplasmic protein
YP_907840.1	membrane protein
YP_907841.1	cytoplasmic protein; required for the transposition of the insertion element IS2606.
YP_907842.1	cytoplasmic protein; function unknown, probably involved in deamination of specific substrate.
YP_907843.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein
YP_907844.1	catalyzes the formation of 4-hydroxyphenylpyruvate from prephenate
YP_907845.1	cytoplasmic protein
YP_907846.1	membrane protein; thought to be involved in active transport of osmoprotectant (glycine betaine/carnitine/choline/L- proline) across the membrane (import) responsible for the translocation of the substrate across the membrane.
YP_907847.1	membrane protein; thought to be involved in active transport of osmoprotectant (glycine betaine/carnitine/choline/L- proline) across the membrane (import) responsible for the translocation of the substrate across the membrane.
YP_907848.1	secreted protein; thought to be involved in active transport of osmoprotectant (glycine betaine/carnitine/choline/L- proline) across the membrane (import)
YP_907849.1	membrane protein
YP_907850.1	cytoplasmic protein
YP_907851.1	secreted protein
YP_907852.1	cytoplasmic protein
YP_907853.1	cytoplasmic protein; function unknown, possibly involved in cellular metabolism.
YP_907854.1	cytoplasmic protein; function unknown, but involved in lipid degradation.
YP_907855.1	cytoplasmic protein
YP_907856.1	membrane protein; possibly binds NADP and acts through a one-electron transfer process. quinones are supposed to be the best substrates. may act in the detoxification of xenobiotics [catalytic activity: NADPH + quinone = NADP+ + semiquinone]
YP_907857.1	cytoplasmic protein; function unknown, probably involved in cellular metabolism.
YP_907858.1	secreted protein
YP_907859.1	cytoplasmic protein; sensor part of a two component regulatory system.
YP_907860.1	cytoplasmic protein; required for the transposition of the insertion element IS2606.
YP_907861.1	membrane protein
YP_907862.1	cytoplasmic protein; required for the transposition of the insertion element IS2606.
YP_907863.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_907864.1	membrane protein
YP_907865.1	membrane protein
YP_907866.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_907867.1	cytoplasmic protein; function unknown, may play a role in secondary metabolites biosynthesis, transport, and catabolism.
YP_907868.1	cytoplasmic protein
YP_907869.1	cytoplasmic protein
YP_907870.1	cytoplasmic protein; involved in histidine biosynthetic pathway (at the eighth step) [catalytic activity: L-histidinol-phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + glutamate]
YP_907871.1	cytoplasmic protein
YP_907872.1	cytoplasmic protein
YP_907873.1	Point mutation has removed stop codon and translationally coupled EchA21 with LipE; Detected in the cytoplasmic fraction by 2D-LC- MS/MS. Also detected in the membrane fraction by proteomics (2D-LC-MS/MS); cytoplasmic protein; function unknown, lipolytic enzyme probably involved in lipid metabolism.
YP_907874.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_907875.1	cytoplasmic protein
YP_907876.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_907877.1	functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family
YP_907878.1	Also detected in the membrane and the cytoplasmic fractions by proteomics; secreted protein; function unknown, possibly involved in cellular metabolism.
YP_907879.1	Detected in the cytoplamic fraction by LCMSMS; cytoplasmic protein; this enzyme may play a significant role in processes leading to recovery from mutagenesis and/or cell death by alkylating agents [catalytic activity: hydrolysis of DNA containing ring-opened N7-methylguanine residues, releasing 2,6-diamino-4-hydroxy-5-(N- methyl)formamidopyrimide]
YP_907880.1	membrane protein
YP_907881.1	catalyzes the formation of precorrin 6x from precorrin 5
YP_907882.1	membrane protein
YP_907883.1	cytoplasmic protein; function unknown, probably involved in cellular metabolism.
YP_907884.1	membrane protein
YP_907885.1	cytoplasmic protein; oxidizes fatty acids using specific components (by similarity) [catalytic activity: (3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H(2)O]
YP_907886.1	cytoplasmic protein
YP_907887.1	membrane protein
YP_907888.1	catalyzes the ATP-dependent formation of a phosphodiester at the site of a single-strand break in duplex DNA and has been shown to have polymerase activity
YP_907889.1	membrane protein; ATP + D-fructose = ADP + D-fructose 6-phosphate
YP_907890.1	cytoplasmic protein
YP_907891.1	Detected in the membrane fraction by proteomics.; membrane protein; involved in active transport of inorganic phosphate across the membrane (import) this is one of the proteins required for binding-protein-mediated phosphate transport.
YP_907892.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; involved in active transport of inorganic phosphate across the membrane (import); responsible for the translocation of the substrate across the membrane. this is one of the proteins required for binding-protein- mediated phosphate transport.
YP_907893.1	membrane protein; involved in active transport of inorganic phosphate across the membrane (import); responsible for the translocation of the substrate across the membrane. this is one of the proteins required for binding-protein- mediated phosphate transport.
YP_907894.1	Detected in the membrane and the secreted protein fractions by proteomics.; secreted protein; involved in active transport of inorganic phosphate across the membrane (import) this is one of the proteins required for binding-protein-mediated phosphate transport.
YP_907895.1	cytoplasmic protein; function unknown, possibly involved in cellular metabolism.
YP_907897.1	membrane protein; H(+)-stimulated, highly selective, divalent cation uptake system. responsible for the translocation of the divalent metal across the membrane.
YP_907898.1	secreted protein
YP_907899.1	CDS appears to have been formed by a DNA deletion that fused the N-term of a conserved hypothetical protein with the C-term of a putative oxidoreductase (MON4219); cytoplasmic protein
YP_907900.1	cytoplasmic protein
YP_907901.1	cytoplasmic protein
YP_907902.1	cytoplasmic protein
YP_907903.1	cytoplasmic protein
YP_907904.1	cytoplasmic protein; transposition of an insertion sequence. possibly IS200 family.
YP_907905.1	membrane protein
YP_907906.1	membrane protein
YP_907907.1	membrane protein
YP_907908.1	membrane protein
YP_907909.1	cytoplasmic protein
YP_907910.1	membrane protein
YP_907911.1	membrane protein
YP_907912.1	membrane protein; function unknown. possibly a protective antigen involved with the early control of infection.
YP_907913.1	cytoplasmic protein; required for the transposition of the insertion element IS2606.
YP_907914.1	cytoplasmic protein; function unknown. seems to be expressed during macrophage infection.
YP_907915.1	cytoplasmic protein; possibly involved in camp synthesis [catalytic activity: ATP = 3',5'-cyclic AMP + diphosphate]
YP_907916.1	cytoplasmic protein; involved in signal transduction (via phosphorylation) thought to be involved in membrane transport. phosphorylates the peptide substrate myelin basic protein (MBP) at serine and threonine residues [catalytic activity: ATP + a protein = ADP + a phosphoprotein]
YP_907917.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_907918.1	cytoplasmic protein; required for the transposition of the insertion element IS2606.
YP_907919.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_907920.1	catalyzes the hydrolysis of a monocarboxylic acid amid to form a monocarboxylate and ammonia
YP_907921.1	cytoplasmic protein
YP_907923.1	cytoplasmic protein
YP_907924.1	cytoplasmic protein; function unknown, probably involved in cellular metabolism.
YP_907925.1	cytoplasmic protein
YP_907926.1	cytoplasmic protein; function unknown, probably involved in cellular metabolism
YP_907927.1	cytoplasmic protein; involved in transcriptional mechanism.
YP_907928.1	membrane protein
YP_907929.1	cytoplasmic protein
YP_907930.1	membrane protein
YP_907931.1	membrane protein; catalyzes the acylation of the mycaminose sugar during midecamycin biosynthesis
YP_907932.1	membrane protein
YP_907933.1	cytoplasmic protein
YP_907934.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_907935.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_907936.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_907937.1	kgd; produces succinic semialdehyde; part of alternative pathway from alpha-ketoglutarate to succinate; essential for normal growth
YP_907938.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS. Also detected in the membrane fraction by proteomics (LC-MS/MS); cytoplasmic protein; function unknown, supposed involved in cellular metabolism.
YP_907939.1	secreted protein
YP_907940.1	membrane protein; catalizes the oxidative decarboxylation of malate into pyruvate, important for a wide range of metabolic pathways [catalytic activity: (S)-malate + NAD(+) = pyruvate + CO(2) + NADH]
YP_907941.1	catalyzes the oxidation of malate to oxaloacetate
YP_907942.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_907943.1	cytoplasmic protein; catalyzes oxidation of glucose-6-phosphate to 6- phosphogluconolactone using coenzyme F420 (an *-hydroxy-5- deazaflavin derivative) as the electron acceptor.
YP_907944.1	membrane protein; involved in 4-aminobutyrate (GabA) degradation pathway. transporter for GabA. responsible for the translocation of the substrate across the membrane.
YP_907945.1	membrane protein
YP_907946.1	membrane protein; involved in active transport of sugar across the membrane (import) responsible for the translocation of the substrate across the membrane.
YP_907947.1	secreted protein; involved in active transport of sugar across the membrane (import) responsible for the translocation of the substrate across the membrane.
YP_907949.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; function unknown: thought to be an ATP-binding protein.
YP_907950.1	mediates the export of protein precursors bearing twin-arginine signal peptides
YP_907951.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; possibly hydrolyzes peptides and/or proteins (seems to cleave preferentially after serine residue)
YP_907952.1	cytoplasmic protein
YP_907953.1	Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; in M. tuberculosis this protein is involved in heat shock, oxidative stress and virulence
YP_907954.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; function unknown, involved in cellular metabolism
YP_907955.1	membrane protein
YP_907956.1	membrane protein
YP_907957.1	catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate
YP_907958.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_907959.1	cytoplasmic protein; required for the transposition of the insertion element IS2606.
YP_907960.1	Detected in the membrane fraction by proteomics (LC- MS/MS); cytoplasmic protein
YP_907961.1	cytoplasmic protein; possibly involved in transcriptional mechanism.
YP_907962.1	cytoplasmic protein
YP_907963.1	Also detected in the membrane fraction by proteomics (2D-LC-MS/MS); cytoplasmic protein; involved in glyoxylate bypass (at the first step), an alternative to the tricarboxylic acid cycle (in bacteria, plants, and fungi) [catalytic activity: isocitrate = succinate + glyoxylate] involved in the persistence in the host.
YP_907964.1	converts (S)-3-hydroxybutanoyl-CoA to 3-acetoacetyl-CoA
YP_907965.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS. Also detected in the membrane fraction by proteomics (LC-MS/MS); cytoplasmic protein; involved in mycolic acid modification or synthesis.
YP_907966.1	cytoplasmic protein; involved in the mycolic acid modification or synthesis; essential for the cyclopropanation function. required for cording and mycolic acid cyclopropane ring synthesis in the cell wall.
YP_907967.1	cytoplasmic protein; possibly involved in transcriptional mechanism.
YP_907968.1	membrane protein
YP_907969.1	cytoplasmic protein; possibly involved in transcriptional mechanism.
YP_907970.1	Also detected in the cytoplasmic fraction y proteomics; membrane protein; required for extrapulmonary dissemination. mediates adherence to epithelial cells by binding to sulfated glycoconjugates present at the surface of these cells; binds heparin, dextran sulfate, fucoidan and chondroitin sulfate. promotes hemagglutination of erythrocytes of certain host species. induces mycobacterial aggregation.
YP_907971.1	membrane protein
YP_907972.1	secreted protein
YP_907973.1	catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate
YP_907974.1	Mutation has removed potential u/s start codon; Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_907975.1	cytoplasmic protein; function unknown, hydrolytic enzyme probably involved in cellular metabolism.
YP_907976.1	cytoplasmic protein
YP_907977.1	catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis
YP_907978.1	membrane protein
YP_907979.1	cytoplasmic protein; function unknown, possibly involved in cellular metabolism.
YP_907980.1	cytoplasmic protein; possibly involved in transcriptional mechanism.
YP_907981.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS; cytoplasmic protein; thought to be involved in polyprenolmannose synthesis.
YP_907982.1	cytoplasmic protein
YP_907983.1	2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate
YP_907984.1	membrane protein; sensor part of a two component regulatory system. probably forms part of a two-component regulatory system SenX3/RegX3; phosphorylates RegX3.
YP_907985.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; transcriptional regulatory protein part of the two component regulatory system RegX3/SenX3.
YP_907986.1	membrane protein; function unknown, probably involved in cellular metabolism.
YP_907987.1	membrane protein
YP_907988.1	cytoplasmic protein; involved in transcriptional mechanism.
YP_907989.1	cytoplasmic protein
YP_907990.1	cytoplasmic protein
YP_907991.1	Also detected in the cytoplasmic fraction by 2D-LC- MS/MS.; membrane protein
YP_907992.1	cytoplasmic protein
YP_907993.1	cytoplasmic protein
YP_907994.1	catalyzes the formation of L-proline from pyrroline-5-carboxylate
YP_907995.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS. Also detected in the membrane fraction by proteomics (LC-MS/MS); cytoplasmic protein
YP_907996.1	cytoplasmic protein
YP_907997.1	cytoplasmic protein; involved in galactose metabolism [catalytic activity: UDP-glucose = UDP-galactose]
YP_907998.1	Detected in the secreted fraction by proteomics.; cytoplasmic protein
YP_907999.1	cytoplasmic protein; essential for the cyclopropanation function. transfers a methylene group from S-adenosyl-L-methionine to the cis double bond of an unsaturated fatty acid chain resulting in the replacement of the double bond with a methylene bridge. mycolic acids, which represent the major constituent of mycobacterial cell wall complex, act as substrates [catalytic activity: S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L- homocysteine + phospholipid cyclopropane fatty acid]
YP_908000.1	cytoplasmic protein
YP_908001.1	Detected in the membrane fraction by proteomics (LC- MS/MS); cytoplasmic protein; removes a phosphate from phosphoserine [catalytic activity: phosphoserine + H2O = serine + phosphate]
YP_908002.1	cytoplasmic protein; involved in cellular metabolism [catalytic activity: CO + H(2)O + acceptor = CO(2) + reduced acceptor]
YP_908003.1	cytoplasmic protein; function unknown, probably involved in cellular metabolism [catalytic activity: CO + H(2)O + acceptor = CO(2) + reduced acceptor]
YP_908004.1	membrane protein; involved in cellular metabolism [catalytic activity: CO + H(2)O + acceptor = CO(2) + reduced acceptor]
YP_908005.1	membrane protein
YP_908006.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_908007.1	cytoplasmic protein; required for the transposition of the insertion element IS2606.
YP_908008.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_908009.1	cytoplasmic protein; required for the transposition of the insertion element IS2606.
YP_908010.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_908011.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_908012.1	cytoplasmic protein
YP_908013.1	cytoplasmic protein
YP_908014.1	cytoplasmic protein
YP_908015.1	cytoplasmic protein
YP_908016.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_908017.1	cytoplasmic protein
YP_908018.1	catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins
YP_908019.1	transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis
YP_908020.1	cytoplasmic protein; possibly involved in the biosynthesis of siroheme and cobalamin [catalytic activity: 2 S-adenosyl-L- methionine + uroporphyrin III = 2 S-adenosyl-L- homocysteine + sirohydrochlorin]
YP_908021.1	catalyzes the formation of porphobilinogen from 5-aminolevulinate
YP_908022.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_908023.1	membrane protein
YP_908025.1	cytoplasmic protein; required for the transposition of the insertion element IS2606.
YP_908026.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_908027.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_908028.1	membrane protein
YP_908029.1	cytoplasmic protein; required for the transposition of the insertion element IS2606.
YP_908030.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_908031.1	membrane protein
YP_908032.1	membrane protein
YP_908033.1	membrane protein
YP_908034.1	PE8; membrane protein
YP_908035.1	PPE15; membrane protein
YP_908036.1	Detected in the membrane fraction by proteomics (2D- LC-MS/MS); membrane protein
YP_908037.1	Also detected in the cytoplasmic fraction by 2D-LC- MS/MS.; membrane protein
YP_908038.1	cytoplasmic protein; sensor part of the two component regulatory system TrcS/TrcR. involved in transcriptional autoactivation: TrcR activates its own expression by interacting with the AT-rich sequence of the TrcR promoter.
YP_908039.1	membrane protein; sensor part of the two component regulatory system TrcS/TrcR.
YP_908040.1	cytoplasmic protein; function unknown, possibly involved in amino acid transport and metabolism.
YP_908041.1	cytoplasmic protein
YP_908042.1	cytoplasmic protein; function unknown; identity to GppA, exopolyphosphatase [nucleotide transport and metabolism / inorganic ion transport and metabolism]
YP_908043.1	cytoplasmic protein
YP_908044.1	membrane protein
YP_908045.1	enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis
YP_908046.1	secreted protein
YP_908047.1	functions in degradation of stringent response intracellular messenger ppGpp; in Escherichia coli this gene is co-transcribed with the toxin/antitoxin genes mazEF; activity of MazG is inhibited by MazEF in vitro; ppGpp inhibits mazEF expression; MazG thus works in limiting the toxic activity of the MazF toxin induced during starvation; MazG also interacts with the GTPase protein Era
YP_908048.1	cytoplasmic protein; involved in nucleotide excision repair. necessary for strand-specific repair. a lesion in the template strand blocks the RNA polymerase complex (RNAP) the RNAP- DNA-RNA complex is specifically recognized by TrcF which releases RNAP and the truncated transcript; the TcrF may replace RNAP at the lesion site and then recruit the UvrA/B/C repair system.
YP_908049.1	cytoplasmic protein; involved in transcriptional mechanism.
YP_908050.1	forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis
YP_908051.1	catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP
YP_908052.1	cytoplasmic protein
YP_908053.1	Also detected in the membrane fraction by proteomics (LC-MS/MS); secreted protein
YP_908054.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_908055.1	the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response
YP_908056.1	Enables the recycling of peptidyl-tRNAs produced at termination of translation
YP_908057.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_908058.1	activates fatty acids by binding to coenzyme A
YP_908059.1	catalyzes the phosphorylation of 4-diphosphocytidyl-2-C-methyl-D-erythritol in the nonmevalonate pathway of isoprenoid biosynthesis
YP_908060.1	catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin
YP_908061.1	secreted protein; thought to promote the resuscitation and growth of dormant, nongrowing cell. could also stimulates the growth of several other high G+C Gram+ organisms, E.G. mycobacterium avium, mycobacterium bovis (BCG), mycobacterium kansasii, mycobacterium smegmatis.
YP_908062.1	membrane protein; DNAse involved in proteins export. this sec- independent pathway is termed tat for twin-arginine translocation system. this system mainly transports proteins with bound cofactors that require folding prior to export (by similarity)
YP_908063.1	methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content
YP_908064.1	cytoplasmic protein; involved in cysteine biosynthesis [catalytic activity: acetyl-CoA + L-serine = CoA + O-acetyl-L- serine]
YP_908065.1	cytoplasmic protein; function unknown, probably involved in cellular metabolism
YP_908066.1	catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine
YP_908067.1	cytoplasmic protein
YP_908068.1	membrane protein
YP_908069.1	catalyzes the degradation of arginine to citruline and ammonia
YP_908070.1	cytoplasmic protein
YP_908071.1	secreted protein
YP_908072.1	secreted protein
YP_908073.1	cytoplasmic protein
YP_908074.1	cytoplasmic protein; thought to cause methylation.
YP_908075.1	cytoplasmic protein
YP_908076.1	membrane protein
YP_908077.1	membrane protein
YP_908078.1	membrane protein
YP_908079.1	cytoplasmic protein; function unknown, possibly involved in cell envelope biogenesis, outer membrane
YP_908080.1	membrane protein; function unknown, possibly involved in lipopolysaccharide synthesis.
YP_908081.1	membrane protein; function unknown, possible membrane protein involved in the export of O-antigen and teichoic acid.
YP_908082.1	cytoplasmic protein; probably involved in cell wall synthesis
YP_908083.1	cytoplasmic protein; function unknown, contains RfaG, glycosyltransferase domain. may be involved in cell envelope biogenesis, outer membrane.
YP_908084.1	cytoplasmic protein
YP_908085.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_908086.1	cytoplasmic protein
YP_908087.1	cytoplasmic protein
YP_908088.1	cytoplasmic protein
YP_908089.1	cytoplasmic protein; function unknown; hydrolytic enzyme probably involved in cellular metabolism.
YP_908090.1	cytoplasmic protein
YP_908091.1	membrane protein
YP_908092.1	cytoplasmic protein
YP_908093.1	membrane protein
YP_908094.1	cytoplasmic protein; this enzyme acetylates the N-terminal alanine of ribosomal protein S5 [catalytic activity: acetyl-CoA + ribosomal-protein L-alanine = CoA + ribosomal-protein N- acetyl-L-alanine]
YP_908095.1	cytoplasmic protein; involved in molybdenum cofactor biosynthesis: involved in the biosynthesis of a demolybdo-cofactor (molybdopterin), necessary for molybdo-enzymes.
YP_908096.1	cytoplasmic protein; may play a role in stationary phase survival [catalytic activity: UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose]
YP_908097.1	cytoplasmic protein
YP_908098.1	cytoplasmic protein
YP_908099.1	membrane protein
YP_908100.1	forms homopentamer; channel that opens in response to pressure or hypoosmotic shock
YP_908101.1	Detected in the cytoplasmic and secreted fractions by proteomics.; cytoplasmic protein; thought to be involved in molybdopterin biosynthesis. catalyzes the dehydratation of 4A- hydroxytetrahydropterins [catalytic activity: (6R)-6-(L- erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro -4 A- hydroxypterin = (6R)-6-(L-erythro-1,2- dihydroxypropyl)- 7,8-dihydro-6H-pterin + H(2)O]
YP_908102.1	Non-secretory protein; membrane protein; function unknown, possibly hydrolyzes peptides and/or proteins (seems to cleave preferentially after serine residues)
YP_908103.1	membrane protein; sensor part of a two component regulatory system (supposed MprAB system)
YP_908104.1	cytoplasmic protein; regulator part of a two component regulatory system (supposed MprAB system)
YP_908105.1	some L32 proteins have zinc finger motifs consisting of CXXC while others do not
YP_908106.1	cytoplasmic protein
YP_908107.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; function unknown, but involved in lipid degradation.
YP_908108.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; involved in fatty acid metabolism.
YP_908109.1	Detected in the membrane fraction by proteomics (2D- LC-MS/MS); cytoplasmic protein; this protein carries two functions: biotin carboxyl carrier protein and biotin carboxyltransferase. involved in the first step of long-chain fatty acid synthesis [catalytic activity: ATP + biotin-carboxyl-carrier protein + CO(2) = ADP + phosphate + carboxybiotin-carboxyl-carrier protein]
YP_908110.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; function unknown, but involved in lipid metabolism.
YP_908111.1	Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA
YP_908112.1	cytoplasmic protein
YP_908113.1	cytoplasmic protein
YP_908114.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; chelation, introducing a magnesium ion into specific substrate.
YP_908115.1	involved in de novo purine biosynthesis
YP_908116.1	glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate
YP_908117.1	membrane protein
YP_908118.1	membrane protein
YP_908119.1	Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation
YP_908120.1	Catalyzes the only substrate-level phosphorylation in the TCA cycle
YP_908121.1	catalyzes the interconversion of succinyl-CoA and succinate
YP_908122.1	cytoplasmic protein
YP_908123.1	membrane protein
YP_908124.1	cytoplasmic protein; involved in nucleotide excision repair. has a 3'-5' helicase activity in presence of ATP. preferred substrate being one with both single and double stranded regions of DNA.
YP_908125.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_908126.1	cytoplasmic protein; required for the transposition of the insertion element IS2606.
YP_908127.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_908128.1	cytoplasmic protein; involved in transcriptional mechanism.
YP_908129.1	fragment; cytoplasmic protein
YP_908130.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; the transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane [catalytic activity: NADPH + NAD+ = NADP+ + NADH]
YP_908131.1	membrane protein; the transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane [catalytic activity: NADPH + NAD+ = NADP+ + NADH]
YP_908132.1	Detected in the cytoplasmic and secreted  fractions by 2D-LC-MS/MS.; cytoplasmic protein; the transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane [catalytic activity: NADPH + NAD+ = NADP+ + NADH]
YP_908133.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein
YP_908134.1	cytoplasmic protein
YP_908135.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; involved in signal transduction (via dephosphorylation) can dephosphorylated in vitro the phosphotyrosine residue of myelin basic protein (MBP) at ph 7.0. could be involved in virulence by interfering with phosphotyrosine-mediated signals in macrophages [catalytic activity: protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate]
YP_908136.1	cytoplasmic protein
YP_908137.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_908138.1	predicted by Cello and psort. Detected in the secreted fraction by 2D-LC-MS-MS.; secreted protein; possibly hydrolyzes specific sugar (hydrolyzation of glycosidic bond) and could be involved in exopolysaccharide biosynthesis/degradation. could also have a lytic activity against cell walls.
YP_908139.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_908140.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_908141.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_908142.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_908143.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_908144.1	membrane protein; involved in signal transduction (via phosphorylation) involved in transcriptional regulatory mechanism and in the regulation of secondary metabolites [catalytic activity: ATP + a protein = ADP + a phosphoprotein]
YP_908145.1	membrane protein; involved in signal transduction (via phosphorylation) involved in transcriptional regulatory mechanism and in the regulation of secondary metabolites [catalytic activity: ATP + a protein = ADP + a phosphoprotein]
YP_908146.1	cytoplasmic protein
YP_908147.1	membrane protein
YP_908148.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein
YP_908149.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; possibly binds NADP and acts through a one-electron transfer process. quinones are supposed to be the best substrates. may act in the detoxification of xenobiotics [catalytic activity: NADPH + quinone = NADP+ + semiquinone]
YP_908150.1	Found in the cytoplasmic and membrane fractions by LC-MS/MS. Also detected in the secreted protein and extracellular matrix fractions by proteomics.; cytoplasmic protein; function unknown, possibly involved in cellular metabolism.
YP_908151.1	Detected in the membrane and the cytoplasmic fractions by proteomics.; cytoplasmic protein; function unknown, probably involved in cellular metabolism [catalytic activity: an aldehyde + NAD+ + H2O = an acid + NADH]
YP_908152.1	cytoplasmic protein
YP_908153.1	cytoplasmic protein
YP_908154.1	cytoplasmic protein
YP_908155.1	cytoplasmic protein
YP_908156.1	cytoplasmic protein; involved in transcriptional mechanism.
YP_908157.1	Detected in the cytoplasmic fraction by proteomics.; cytoplasmic protein
YP_908158.1	cytoplasmic protein
YP_908159.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein
YP_908160.1	cytoplasmic protein; function unknown, probably involved in cellular metabolism.
YP_908161.1	cytoplasmic protein
YP_908162.1	this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; provides protection against oxidative stress
YP_908163.1	cytoplasmic protein; could be involved in transcriptional mechanism.
YP_908164.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.Also detected in the membrane fraction by proteomics (2D-LC-MS/MS); cytoplasmic protein
YP_908165.1	cytoplasmic protein; oxido-reduction
YP_908166.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; thought to be involved in detoxification reactions following oxidative damage to lipids [catalytic activity: an epoxide + H(2)O = a glycol]
YP_908167.1	cytoplasmic protein; involved in transcriptional mechanism.
YP_908168.1	cytoplasmic protein
YP_908169.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; function unknown, probably involved in cellular metabolism.
YP_908170.1	cytoplasmic protein
YP_908171.1	membrane protein; thought to be involved in lipid metabolism [catalytic activity: linoleoyl-CoA + ah(2) + O(2) = gamma- linolenoyl-CoA + a + 2 H(2)O]
YP_908172.1	cytoplasmic protein; function unknown, contains flavodoxin reductases (ferredoxin-NADPH reductases) family 1 domain. [energy production and conversion]
YP_908173.1	cytoplasmic protein; involved in transcriptional mechanism.
YP_908174.1	cytoplasmic protein; function unknown, probably involved in cellular metabolism.
YP_908175.1	Detected in the cytoplamic fraction by LC-MS/MS. Also detected in the membrane fraction by proteomics (2D- LC-MS/MS); cytoplasmic protein; function unknown, but involved in lipid degradation.
YP_908176.1	cytoplasmic protein
YP_908177.1	cytoplasmic protein
YP_908178.1	Also detected in the cytoplasm and the membrane fractions by proteomics.; secreted protein; proteins of the antigen 85 complex are responsible for the high affinity of mycobacteria to fibronectin. possesses a mycolyltransferase activity required for the biogenesis of trehalose dimycolate (cord factor), a dominant structure necessary for maintaining cell wall integrity.
YP_908179.1	Detected in the extracellular matrix and the cytoplasmic fractions by proteomics.; cytoplasmic protein
YP_908180.1	Detected in the membrane fraction by proteomics (2D- LC-MS/MS); cytoplasmic protein; involved in trehalose biosynthesis (protective effect) converts maltose to trehalose. mycobacteria can produce trehalose from glucose 6-phosphate and UDP-glucose (the OtsA-OtsB pathway) from glycogen-like alpha(1-->4)- linked glucose polymers (the TreY-TreZ pathway) and from maltose (the TreS pathway)
YP_908181.1	Three isoforms were also detected in the cytoplasm.; secreted protein; function unknown, possibly hydrolyzes peptides and/or proteins (seems to cleave preferentially after serine residues)
YP_908182.1	cytoplasmic protein; maybe involved in oxidization of aromatic hydrocarbons
YP_908183.1	cytoplasmic protein
YP_908184.1	membrane protein
YP_908185.1	activates fatty acids by binding to coenzyme A
YP_908186.1	catalyzes the formation of formyl-CoA from oxalyl-CoA
YP_908187.1	cytoplasmic protein; could effect functions of OxyR during evolution.
YP_908188.1	secreted protein
YP_908189.1	membrane protein; H(+)-stimulated, highly selective, divalent cation uptake system. responsible for the translocation of the divalent metal across the membrane.
YP_908191.1	cytoplasmic protein; thought to be involved in transfer of methyl group.
YP_908192.1	membrane protein; function unknown, probably involved in cellular metabolism.
YP_908193.1	cytoplasmic protein; function unknown.  possibly involved in energy production and conversion.
YP_908194.1	cytoplasmic protein; function unknown, possibly involved in cellular metabolism.
YP_908195.1	cytoplasmic protein; function unknown, probably involved in cellular metabolism
YP_908196.1	cytoplasmic protein; function unknown, probably involved in cellular metabolism
YP_908197.1	cytoplasmic protein
YP_908198.1	cytoplasmic protein; involved in transcriptional mechanism.
YP_908199.1	cytoplasmic protein; function unknown, possibly involved in cellular metabolism.
YP_908200.1	membrane protein
YP_908201.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_908202.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS, and also in the membrane fraction by proteomics (LC- MS/MS); cytoplasmic protein
YP_908203.1	Detected in the membrane fraction by proteomics (LC- MS/MS) Also detected in the cytoplasmic fraction by 2D-LC- MS/MS.; membrane protein; cation-transporting ATPase; possibly catalyzes the transport of a cation (possibly magnesium) with the hydrolyse of ATP [catalytic activity: ATP + H(2)O + cation(in) = ADP + phosphate + cation(out)]
YP_908204.1	activates fatty acids by binding to coenzyme A
YP_908205.1	cytoplasmic protein; function unknown; supposed involved in cellular metabolism.
YP_908206.1	RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome
YP_908207.1	Detected in the membrane fraction by proteomics.; cytoplasmic protein
YP_908208.1	cytoplasmic protein; involved in ribosome activity
YP_908209.1	in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif
YP_908210.1	located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif
YP_908211.1	binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit
YP_908212.1	cytoplasmic protein
YP_908213.1	cytoplasmic protein; involved in transcriptional mechanism.
YP_908214.1	cytoplasmic protein; function unknown, probably involved in cellular metabolism
YP_908215.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_908216.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; function unknown, probably involved in cellular metabolism
YP_908217.1	membrane protein; cation-transporting ATPase; possibly catalyzes the transport of a cation (possibly coopper) with the hydrolyse of ATP [catalytic activity: ATP + H(2)O + cation(in) = ADP + orthophosphate + cation(out)]
YP_908218.1	Detected in the cytoplasmic and secreted protein fractions by 2D-LC-MS/MS.; secreted protein
YP_908219.1	membrane protein
YP_908220.1	secreted protein
YP_908221.1	cytoplasmic protein; involved in promoter recognition, transcription initiation.
YP_908222.1	membrane protein; cation-transporting ATPase; possibly catalyzes the transport of a cation (possibly copper) with the hydrolyse of ATP [catalytic activity: ATP + H(2)O + cation(in) = ADP + phosphate + cation(out)]
YP_908223.1	membrane protein
YP_908224.1	cytoplasmic protein; function unknown, but supposed involved in lipid metabolism
YP_908225.1	PPE1; membrane protein
YP_908226.1	cytoplasmic protein; function unknown, probably involved in cellular metabolism.
YP_908227.1	cytoplasmic protein
YP_908228.1	activates fatty acids by binding to coenzyme A
YP_908229.1	cytoplasmic protein
YP_908230.1	membrane protein; involved in lipid metabolism.
YP_908231.1	cytoplasmic protein; function unknown, but possibly involvement in lipid metabolism.
YP_908232.1	cytoplasmic protein
YP_908233.1	cytoplasmic protein; responsible for cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and s- adenosylhomocysteine (sah) [catalytic activity 1: methylthioadenosine + H2O = adenine + 5-methylthio-D- ribose] [catalytic activity 2: S-adenosyl-L-homocysteine + H2O = adenine + S-D-ribosyl-L-homocysteine]
YP_908234.1	cytoplasmic protein
YP_908235.1	cytoplasmic protein; possibly involved in transcriptional mechanism.
YP_908236.1	cytoplasmic protein; function unknown, possibly involved in cellular metabolism.
YP_908237.1	cytoplasmic protein
YP_908238.1	membrane protein
YP_908239.1	cytoplasmic protein; oxidizes fatty acids using specific components (by similarity) [catalytic activity: (3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H(2)O]
YP_908240.1	cytoplasmic protein; thought to cause methylation.
YP_908241.1	cytoplasmic protein; function unknown, possibly involved in cellular metabolism.
YP_908242.1	cytoplasmic protein; function unknown, generates an aldehyde (or perhaps a ketone) from an alcohol.
YP_908243.1	membrane protein; function unknown, involved in cellular metabolism.
YP_908244.1	Detected in the cytoplasmic and membrane fractions by proteomics.; cytoplasmic protein; involved in transcriptional mechanism.
YP_908245.1	cytoplasmic protein; involved in transcriptional mechanism.
YP_908246.1	cytoplasmic protein; function unknown.  possibly involved in cellular metabolism.
YP_908247.1	cytoplasmic protein
YP_908248.1	cytoplasmic protein; function unknown, contains copper chaperone domain.
YP_908249.1	secreted protein
YP_908250.1	membrane protein; function unknown, involved in cellular metabolism.
YP_908251.1	cytoplasmic protein
YP_908252.1	cytoplasmic protein; function unknown.  contains HTH motif. may be involved in transcription regulation.
YP_908253.1	cytoplasmic protein
YP_908254.1	secreted protein
YP_908255.1	cytoplasmic protein; possibly involved in transcriptional mechanism.
YP_908256.1	cytoplasmic protein; function unknown, probably involved in cellular metabolism.
YP_908257.1	cytoplasmic protein; involved in transcriptional mechanism.
YP_908258.1	cytoplasmic protein
YP_908259.1	cytoplasmic protein; required for the transposition of the insertion element IS2606.
YP_908260.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_908261.1	cytoplasmic protein
YP_908262.1	membrane protein; function unknown, probably involved in cellular metabolism
YP_908263.1	cytoplasmic protein; involved in gluconeogenesis from serine [catalytic activity: L-serine + H2O = pyruvate + NH3 + H2O]
YP_908264.1	catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate
YP_908265.1	cytoplasmic protein; the glycine cleavage system catalyses the degradation of glycine. the H protein shuttles the methylamine group of glycine from the P protein to the T protein
YP_908267.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_908268.1	membrane protein
YP_908269.1	disruption by insertion sequence (missing 11 aa); secreted protein
YP_908270.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_908271.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_908272.1	membrane protein; function unknown, but thought involved in host cell invasion.
YP_908273.1	membrane protein; function unknown, but thought to be involved in host cell invasion.
YP_908274.1	Detected in the membrane fraction by proteomics (2D- LC-MS/MS); membrane protein; function unknown, but thought to be involved in host cell invasion.
YP_908275.1	membrane protein; function unknown, but thought to be involved in host cell invasion.
YP_908276.1	membrane protein; function unknown, but thought to be involved in host cell invasion.
YP_908277.1	membrane protein; function unknown, but thought to be involved in host cell invasion.
YP_908278.1	membrane protein
YP_908279.1	membrane protein
YP_908280.1	activates fatty acids by binding to coenzyme A
YP_908281.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; thought to be involved in de novo fatty acid biosynthesis; this protein is the carrier of the growing fatty acid chain in fatty acid biosynthesis
YP_908282.1	Detected in the membrane fraction by proteomics (2D- LC-MS/MS); membrane protein
YP_908283.1	Detected in the membrane fraction by proteomics (LC- MS/MS) Also detected in the cytoplamic and extracellular matrix fractions.; membrane protein; probably involved in active transport of substrate across the membrane (export) responsible for energy coupling to the transport system.
YP_908284.1	Also detected in the cytoplamic, the extracellular matrix and the membrane fractions by proteomics.; membrane protein
YP_908285.1	Detected in cytoplasmic and membrane fraction by proteomics.; cytoplasmic protein
YP_908286.1	Detected in the membrane fraction by proteomics (2D- LC-MS/MS); cytoplasmic protein
YP_908287.1	Detected in the cytoplamic fraction by LC-MS/MS. Also detected in the extracellular matrix  and membrane fraction by proteomics.; cytoplasmic protein; catalyzes the production of GabA [catalytic activity: L-glutamate = 4-aminobutanoate + CO(2)]
YP_908288.1	Detected in the membrane fraction by proteomics.; cytoplasmic protein
YP_908289.1	membrane protein; function unknown.
YP_908290.1	Detected in the membrane fraction by proteomics.; membrane protein; function unknown, probably involved in cellular metabolism.
YP_908291.1	Also detected in the membrane fraction by proteomics.; cytoplasmic protein
YP_908292.1	membrane protein
YP_908293.1	membrane protein
YP_908294.1	secreted protein; function unknown.  possibly secreted.
YP_908295.1	membrane protein
YP_908296.1	Also detected in the membrane fraction by proteomics (LC-MS/MS); cytoplasmic protein; involved in the krebs cycle [catalytic activity: isocitrate + NADP+ = 2-oxoglutarate + CO(2) + NADPH]
YP_908297.1	cytoplasmic protein; possibly involved in camp synthesis [catalytic activity: ATP = 3',5'-cyclic AMP + diphosphate]
YP_908298.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS.; cytoplasmic protein; function unknown, but possibly involvement in lipid degradation.
YP_908299.1	cytoplasmic protein; function unknown, probably involved in cellular metabolism.
YP_908300.1	cytoplasmic protein
YP_908301.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_908302.1	cytoplasmic protein; involved in transcriptional mechanism.
YP_908303.1	Detected in the cytoplasmic fraction by proteomics. Also detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; function unknown, but involved in lipid degradation [catalytic activity: acyl-CoA + ETF = 2,3-dehydroacyl-CoA + reduced ETF]
YP_908304.1	membrane protein; function unknown, glycosyltransferases, related to UDP-glucuronosyltransferase
YP_908305.1	secreted protein; function unknown.
YP_908306.1	cytoplasmic protein
YP_908307.1	cytoplasmic protein
YP_908308.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_908309.1	cytoplasmic protein
YP_908310.1	membrane protein; possibly catalyzes the transfer of a great variety of lipids between membranes.
YP_908311.1	Detected in the membrane fraction by proteomics (2D- LC-MS/MS); cytoplasmic protein; involved in transcriptional mechanism.
YP_908312.1	cytoplasmic protein
YP_908313.1	membrane protein; function unknown, but involved in lipid degradation.
YP_908314.1	cytoplasmic protein
YP_908315.1	cytoplasmic protein
YP_908316.1	membrane protein
YP_908317.1	cytoplasmic protein
YP_908318.1	cytoplasmic protein
YP_908319.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_908320.1	Regulates the synthesis of nucleoside triphosphates for nucleic acid synthesis, CTP for lipid synthesis, and GTP for protein elongation
YP_908321.1	membrane protein
YP_908322.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; function unknown, probably involved in cellular metabolism.
YP_908323.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; function unknown, supposed involved in cellular metabolism.
YP_908324.1	membrane protein
YP_908325.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; involved in the biosynthesis of the mycobacterial cell wall arabinan and resistance to ethambutol (Emb; dextro-2,2'-(ethylenediimino)-di-1-butanol) polymerizes arabinose into the arabinan of arabiogalactan [catalytic activity: UDP-L-arabinose + indol-3-ylacetyl-myo-inositol = UDP + indol-3-ylacetyl-myo-inositol L-arabinoside]
YP_908326.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; involved in the biosynthesis of the mycobacterial cell wall arabinan and resistance to ethambutol (Emb; dextro-2,2'-(ethylenediimino)-di-1-butanol) polymerizes arabinose into the arabinan of arabiogalactan [catalytic activity: UDP-L-arabinose + indol-3-ylacetyl-myo-inositol = UDP + indol-3-ylacetyl-myo-inositol L-arabinoside]
YP_908327.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; involved in the biosynthesis of the mycobacterial cell wall arabinan and resistance to ethambutol (Emb; dextro-2,2'-(ethylenediimino)-di-1-butanol) polymerizes arabinose into the arabinan of arabiogalactan [catalytic activity: UDP-L-arabinose + indol-3-ylacetyl-myo-inositol = UDP + indol-3-ylacetyl-myo-inositol L-arabinoside]
YP_908328.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_908329.1	secreted protein
YP_908330.1	membrane protein
YP_908331.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; key enzyme in the catabolic pathway of odd-chain fatty acids, isoleucine, threonine, methionine, and valine [catalytic activity: ATP + propionyl-CoA + CO(2) + H(2)O = ADP + orthophosphate + methylmalonyl-CoA]
YP_908332.1	cytoplasmic protein; the enzyme responsible for the final condensation step in mycolic acid biosynthesis, bringing the short and long (mero) chains together.
YP_908333.1	activates fatty acids by binding to coenzyme A
YP_908334.1	Detected in the membrane fraction by proteomics (LC- MS/MS); secreted protein
YP_908335.1	Also detected in the membrane fraction by proteomics (2D-LC-MS/MS); secreted protein; involved in cell wall mycoloylation. proteins of the antigen 85 complex are responsible for the high affinity of mycobacteria to fibronectin. possesses a mycolyltransferase activity required for the biogenesis of trehalose dimycolate (cord factor), a dominant structure necessary for maintaining cell wall integrity.
YP_908336.1	Also detected in the membrane fraction by proteomics (2D-LC-MS/MS); secreted protein; involved in cell wall mycoloylation. proteins of the antigen 85 complex are responsible for the high affinity of mycobacteria to fibronectin. possesses a mycolyltransferase activity required for the biogenesis of trehalose dimycolate (cord factor), a dominant structure necessary for maintaining cell wall integrity.
YP_908337.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_908338.1	catalyzes the formation of decaprenylphosphoryl-5-phosphoribose from phosphoribose diphosphate and decaprenyl phosphate
YP_908339.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_908340.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; converts UDP-galactofuranose in cell wall galactan polymerization. has UDP-GalF:beta-D-(1->5) and UDP- GalF:beta-D-(1->6) galactofuranosyltransferase activities.
YP_908341.1	cytoplasmic protein; involved in lipopolysaccharide biosynthesis, in the conversion of UDP-galactopyranose into UDP-galactofuranose through a 2-keto intermediate [catalytic activity: UDP-D- galactopyranose = UDP-D-galacto-1,4-furanose]
YP_908342.1	secreted protein; surface-exposed protein required for multiplication and intracellular growth. seems to play a role in virulence.
YP_908343.1	secreted protein
YP_908344.1	cytoplasmic protein
YP_908345.1	cytoplasmic protein; function unknown, probably involved in cellular metabolism.
YP_908346.1	cytoplasmic protein; function unknown, probably involved in cellular metabolism.
YP_908347.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein; function unknown, probably involved in cellular metabolism.
YP_908348.1	cytoplasmic protein; function unknown, probably involved in cellular metabolism [catalytic activity: ATP + substrate = ADP + substrate 3'-phosphate]
YP_908349.1	cytoplasmic protein
YP_908350.1	cytoplasmic protein
YP_908351.1	cytoplasmic protein; involved in transcriptional mechanism.
YP_908352.1	membrane protein
YP_908353.1	catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
YP_908354.1	membrane protein
YP_908355.1	cytoplasmic protein
YP_908356.1	cytoplasmic protein; thought to be involved in glycolisis and perhaps glycogen metabolism [catalytic activity: 3- phosphoglycerate = 2-phosphoglycerate]
YP_908357.1	catalyzes the formation of phenylpyruvate from prephenate in phenylalanine biosynthesis
YP_908358.1	cytoplasmic protein
YP_908359.1	membrane protein; supposed involved in transcriptional mechanism.
YP_908360.1	Also detected in the extracellular matrix and the membrane fraction by proteomics.; cytoplasmic protein; involved in iron storage; ferritin is an intracellular molecule that stores iron in a soluble, nontoxic, readily available form. the functional molecule, which is composed of 24 chains, is roughly spherical and contains a central cavity in which the polymeric ferric iron core is deposited.
YP_908361.1	cytoplasmic protein; glycerophosphoryl diester phosphodiesterase hydrolyzes deacylated phospholipids to G3P and the corresponding alcohols [catalytic activity: a glycerophosphodiester + H(2)O = an alcohol + SN-glycerol 3- phosphate]
YP_908362.1	membrane protein
YP_908364.1	Three isoforms were detected in the cytoplasm. Also detected in the extracellular matrix and the membrane fraction by proteomics.; cytoplasmic protein; destroys radicals which are normally produced within the cells and are toxic to biological systems [catalytic activity: 2 peroxide radical + 2 H(+) = O(2) + H(2)O(2)]
YP_908365.1	membrane protein
YP_908366.1	membrane protein
YP_908367.1	Also detected in the membrane fraction by proteomics (2D-LC-MS/MS); cytoplasmic protein
YP_908368.1	Detected in the membrane fraction by proteomics (LC- MS/MS); membrane protein
YP_908369.1	secreted protein
YP_908370.1	cytoplasmic protein
YP_908371.1	regulator of RNase E; increases half-life and abundance of RNAs; interacts with RNase E possibly inhibiting catalytic activity
YP_908372.1	cytoplasmic protein; activates the pro-drug ethionamide (eth); induced eth sensitivity when overexpressed in mycobacterium tuberculosis.
YP_908373.1	cytoplasmic protein; regulates negatively the production of EthA. induced eth resistance when overexpressed in mycobacterium tuberculosis.
YP_908374.1	involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function
YP_908375.1	cytoplasmic protein
YP_908376.1	secreted protein
YP_908377.1	Also detected in the cytoplasm by proteomics.; secreted protein
YP_908378.1	cytoplasmic protein
YP_908379.1	cytoplasmic protein
YP_908381.1	glutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate
YP_908382.1	cytoplasmic protein; probably involved in glutamate biosynthesis [catalytic activity: 2 L-glutamate + NADP(+) = L-glutamine + 2-oxoglutarate + NADPH]
YP_908383.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_908384.1	cytoplasmic protein; required for the transposition of the insertion element IS2606.
YP_908385.1	membrane protein
YP_908386.1	cytoplasmic protein; required for the transposition of insertion element IS2404.
YP_908387.1	cytoplasmic protein
YP_908388.1	cytoplasmic protein
YP_908389.1	membrane protein
YP_908390.1	membrane protein
YP_908391.1	membrane protein
YP_908392.1	cytoplasmic protein
YP_908393.1	cytoplasmic protein
YP_908394.1	cytoplasmic protein; involved in transcription mechanism [catalytic activity: N ATP + (nucleotide)(M) = N diphosphate + (nucleotide)(M+N)]
YP_908395.1	cytoplasmic protein
YP_908396.1	secreted protein
YP_908397.1	Detected in the membrane fraction by proteomics (LC- MS/MS) Also detected in the cytoplasmic fraction by 2D-LC- MS/MS.; membrane protein
YP_908398.1	Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription: in Mycobacterium bovis this protein has been shown to be active at high temperatures and during stationary phase
YP_908399.1	membrane protein
YP_908400.1	Detected in the cytoplasmic fraction by 2D-LC- MS/MS. Also detected in the extracellular matrix and membrane fraction by proteomics.; cytoplasmic protein; enzyme that catalyse the reduction of disulphides by pyridine nucleotides through an enzyme disulphide and a flavin. seems regulated by SigH. [catalytic activity: NADPH + oxidized thioredoxin = NADP(+) + reduced thioredoxin]
YP_908401.1	Detected in the cytoplamic, extracellular matrix and secreted fractions by proteomics.; cytoplasmic protein; thioredoxin participates in various redox reactions through the reversible oxidation of its active center dithiol, to a disulfide, & catalyzes dithiol-disulfide exchange reactions. forms together with thioredoxin reductase and NADPH a redox active system which donates electrons to a wide variety of different metabolic process (by similarity) seems regulated by SigH.
YP_908402.1	cytoplasmic protein; function unknown, probably involved in cellular metabolism.
YP_908403.1	cytoplasmic protein
YP_908404.1	Detected in the membrane fraction by proteomics. Also detected in the cytoplasmic fraction by 2D-LC-MS/MS.; secreted protein; involved in chromosome partition. localize to both poles of the predivisional cell following completion of DNA replication. binds to the DNA origin of replication (by similarity)
YP_908405.1	membrane protein; involved in chromosome partition. localize to both poles of the predivisional cell following completion of DNA replication (by similarity)
YP_908406.1	cytoplasmic protein
YP_908407.1	domain identity suggests it is a Jag RNA-binding protein; Detected in the cytoplasmic fraction by 2D-LC- MS/MS. Also detected in the membrane fraction by proteomics (2D-LC-MS/MS); membrane protein
YP_908408.1	functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria
YP_908409.1	cytoplasmic protein
YP_908410.1	protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates
YP_908411.1	in Escherichia coli transcription of this gene is enhanced by polyamines