-- dump date   	20140619_155355
-- class       	Genbank::Gene
-- table       	gene_note
-- id	note
4552757	conserved hypothetical secreted protein
4550143	glutamine ABC transporter, ATP-binding protein; Frame shift mutation; involved in amino acid transport and metabolism
4550144	ABC transporter permease protein, GlnQ; Frame shift mutation; amino acid transport and metabolism
4551756	non-ribosomal peptide synthetase; frame shift mutation; involved in lipid metabolism.
4551759	integral membrane efflux protein EmrB; Frame shift mutation; translocase that confers resistance to substances of high hydrophobicity. involved in transport of multidrug across the membrane (export): multidrug resistance by an export mechanism. responsible for the translocation of the substrate across the membrane.
4551760	C-term conserved transmembrane transport protein MmpL5_3; DNA deletion; function unknown. thought to be involved in fatty acid transport.
4551762	PE-PGRS family protein; Frame shift mutation
4551765	PE-PGRS family protein; frame shift mutation
4549593	N-term transposase for IS2606; disruption by insertion sequence; required for the transposition of the insertion element IS2606.
4551432	Mg2+ transport transmembrane protein MgtE; frame shift mutation; thought to be involved in Mg2+ transport. responsible for the translocation of the substrate across the membrane.
4551436	membrane-anchored adenylyl cyclase Cya_1; Frame shift mutation; involved in camp synthesis [catalytic activity: ATP = 3',5'-cyclic AMP + diphosphate]
4551437	ethanolamine transporter; stop codon; thought to be involved in cationic amino acid transport across the membrane. responsible for the translocation of the substrate across the membrane.
4551438	ethanolamine ammonia-lyase large subunit; frame shift mutation; cellular metabolism
4551447	carbon monoxyde dehydrogenase (medium chain) - pseudogene, CoxM; Frame shift mutation; function unknown, probably involved in cellular metabolism [catalytic activity: CO + H(2)O + acceptor = CO(2) + reduced acceptor]
4551448	conserved hypothetical protein; Frame shift mutation
4552857	PPE family protein; stop codon
4552866	conserved hypothetical protein; Frame shift mutation
4552878	C-term transposase for IS2606; DNA deletion; required for the transposition of the insertion element IS2606.
4552680	conserved hypothetical protein; N-term frame shift mutation
4552683	PPE family protein; Frame shift mutation
4552685	N-term transposase for IS2606; disruption by insertion sequence; required for the transposition of the insertion element IS2606.
4553969	hypothetical carboxylesterase; Frame shift mutation.; function unknown, possible carboxylesterase type B (lipid metabolism) domain
4553976	conserved hypothetical transmembrane protein; Frame shift mutation
4553978	PhoH-like protein PhoH2; Frame shift mutation
4553916	PE-PGRS family protein; Frame shift mutation
4553922	conserved hypothetical protein; Frame shift mutation
4553925	PE-PGRS family protein; C-term truncated fragment. Internal stop codon.
4549636	C-term conserved hypothetical protein; Truncated. Suspect frame shift mutation
4549639	C-term conserved hypothetical protein; C-term fragment.  Disruption by insertion element IS2404.
4549642	conserved hypothetical protein; C-term fragment. Possible internal stop codon.; function unknown, possibly involved in cell wall biosynthesis.
4549649	membrane-bound C-5 sterol desaturase Erg3_1; Frame shift mutation; involved in lipid desaturation
4549941	conserved exported or membrane protein; Frame shift mutation
4549949	C-term transposase for IS2404; DNA deletion - missing first 60 aa.; required for the transposition of insertion element IS2404.
4549953	transposase for IS2606; frame shift mutation; required for the transposition of the insertion element IS2606.
4554366	conserved hypothetical protein; Frame shift mutation
4554368	C-term fatty-acid-CoA racemase Far; N-term truncated fragment - missing first 139aa.; function unknown, but involvement in lipid degradation (racemization)
4549596	C-term fatty-acid-CoA ligase FadD16; Truncated N-term.; function unknown, but involved in lipid degradation.
4549599	fatty-acid-CoA ligase FadD3_2; Frame shift mutation.; function unknown, but involved in lipid degradation.
4549605	mid-section cytochrome C oxidase subunit III; DNA deletion; function unknown, domain homology to cytochrome C oxidase subunit III
4549611	acyl-CoA dehydrogenase; Frame shift; function unknown, but involved in lipid degradation.
4552644	short-chain type dehydrogenase/reductase; Frame shift mutation; function unknown, possibly involved in cellular metabolism.
4552648	enoyl-CoA hydratase, EchA4_1; Truncated N-term.  Internal stop codon; oxidizes fatty acids using specific components [catalytic activity: (3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H(2)O]
4552651	conserved hypothetical protein; Frame shift mutation
4552656	conserved hypothetical protein; Frame shift mutation; function unknown, domain homology to nucleoside- diphosphate-sugar epimerases
4550870	cysteine synthase a CysK2; Truncated N-term. Frame shift mutation; thought to be involved in cysteine biosynthesis [catalytic activity: O3-acetyl-L-serine + H(2)S = L- cysteine + acetate]
4550883	two component sensor kinase; frame shift mutation; involved in signal transduction mechanism
4550884	dehydrogenase; frame shift mutation
4554401	hypothetical membrane protein; frame shift mutation
4554405	phytoene dehydrogenase CrtI; stop codon; part of a carotenoid biosynthetic gene cluster
4552711	conserved transmembrane transport protein, MmpL13_1; frame shift mutation
4552719	short chain dehydrogenase/reductase; frame-shift
4552721	conserved hypothetical protein; frame-shift
4552723	conserved hypothetical protein; frame shift mutation
4553958	aminopeptidase PepC; stop codon; function unknown, probable involvement in protein or peptide hydrolysis. the catalysed reaction for this class of peptidases (M18 family) involves the release of an N-terminal aminoacid, usually neutral or hydrophobic, from a polypeptide.
4553959	conserved hypothetical protein; Frameshift
4551767	lipoprotein; frame shift mutation
4551774	hypothetical membrane protein; frame-shift
4551779	conserved hypothetical protein; frame shift mutation; function unknown, contains a RyR domain. this domain is called RyR for ryanodine receptor. the domain is found in four copies in the ryanodine receptor. the function of this domain is unknown.
4549977	phosphate-transport integral membrane ABC transporter PstC2_1; Frame-shift mutation.; involved in active transport of inorganic phosphate across the membrane (import); responsible for the translocation of the substrate across the membrane. this is one of the proteins required for binding-protein- mediated phosphate transport
4549981	conserved hypothetical protein; domain conservation - LytR, transcriptional regulator
4549986	hypothetical protein; frame shift mutation, DNA deletion
4549990	C-term conserved hypothetical protein; N-term encoded by MUL_0534 elsewhere on chromosome
4552779	xanthine/uracil permease; frame shift mutation; permease family. this family includes permeases for diverse substrates such as xanthine, uracil and vitamin C. however many members of this family are functionally uncharacterised and may transport other substrates. members of this family have ten predicted transmembrane helices.
4552790	PE_PGRS family protein; frame shift
4550685	dehydrogenase/reductase; frame-shift
4550755	C-term transposase; transposition of an insertion sequence
4550760	C-term helicase; Could be a frameshift mutant with previous orf or truncated by insertion or deletion of DNA or both. Where is N-term?
4552237	C-term helicase; Interrupted by IS2404 and IS2606 insertion
4552249	N-term conserved hypothetical protein; C-term encoded by MUL_451 elsewhere on chromosome.
4549993	PE-PGRS family protein; IS2404 insertion
4549996	conserved hypothetical protein; stop codon
4549998	C-term 3-dehydroquinate synthase AroB_1; DNA deletion; 3-dehydroquinate (DHQ) synthase catalyses the formation of dehydroquinate (DHQ) and orthophosphate from 3-deoxy-D-arabino heptulosonic 7 phosphate. this reaction is part of the shikimate pathway which is involved in the biosynthesis of aromatic amino acids.
4550002	dehydrogenase; frame shift mutation; function unknown, similarity to cyclitol dehydrogenase from actinoplanes sp. 50/110
4550006	C-term conserved hypothetical protein; disruption by insertion sequence
4550698	conserved integral membrane transport protein; Frameshift
4550700	pyrrolidone-carboxylate peptidase Pcp; frame shift mutation; removes 5-oxoproline from various penultimate amino acid residues except L-proline [catalytic activity: 5- oxoprolyl-peptide + H2O = 5-oxoproline + peptide]
4550703	N-term conserved hypothetical membrane protein
4550705	conserved hypothetical membrane protein
4550706	UDP-glucose 6-dehydrogenase UdgA; frame shift mutation; involved in polysaccharide biosynthesis [catalytic activity: UDP-glucose + 2 NAD+ + H2O = UDP-glucuronate + 2 NADH]
4552736	transcriptional regulatory protein; frame shift mutation; involved in transcriptional mechanism.
4553501	carbon monoxide dehydrogenase; stop codon
4553505	PE family protein; frame shift mutation
4553506	L-asparagine permease, AroP2; thought to be involved in transport of L-asparagine across the membrane. responsible for the translocation of the substrate across the membrane.
4553511	mid-section PPE protein; Truncated at N-term by IS2606 insertion
4553513	non-ribosomal peptide synthetase; Frameshift
4550772	glycine-sarcosine methyltransferase; disruption by insertion sequence; contains a UbiE domain: methylase involved in ubiquinone/menaquinone biosynthesis
4550774	GabA permease (gamma-aminobutyrate permease) GabP; frame shift mutation; involved in 4-aminobutyrate (GabA) degradation pathway. transporter for GabA. responsible for the translocation of the substrate across the membrane.
4550776	mandelate racemase; Frameshift
4550779	conserved hypothetical protein; frame shift mutation
4551619	amino acid permease; frame shift mutation
4551626	conserved hypothetical protein; frame shift mutation
4551808	low-affinity inorganic phosphate transporter, PitA; stop codon; involved in low-affinity inorganic phosphate transport across the membrane. responsible for the translocation of the substrate across the membrane.
4553392	lantibiotic modifying enzyme; Frameshift
4554464	cytochrome P450 275B1 Cyp275B1P; frameshift
4554466	C-term transcriptional regulatory protein EmbR_2; Disrupted by IS2404 insertion; involved in transcriptional mechanism.
4554467	transposase for IS2404; frameshift; required for the transposition of insertion element IS2404.
4554468	C-term PPE protein; Truncated by IS2404 insertion
4554472	arylsulfatase AtsA_1; Frame shift; thought to play an important role in the mineralization of sulfates [catalytic activity: a phenol sulfate + H2O = a phenol + sulfate]
4554478	PE-PGRS; frame shift mutation
4553824	conserved hypothetical membrane protein; Frame shift
4553825	conserved hypothetical protein; stop codon
4553831	conserved hypothetical secreted protein; Internal stop codon
4553840	conserved hypothetical transmembrane protein; Internal stop. Predicted esterase domains
4552586	C-term RNA polymerase sigma factor; frame shift mutation
4552127	conserved hypothetical protein; This CDS appears to be the product of two CDS, the second CDS encoding a sigma factor, truncated by a frameshift mutation.; frame shift mutation
4552131	methoxy mycolic acid synthase 1, MmaA1; frame shift mutation; involved in mycolic acids modification. catalyzes unusual S-adenosyl-methionine-dependent transformation of a cis-olefin mycolic acid into a secondary alcohol. catalyzes introduction of a hydroxyl group at the distal position on mycolic acid chains to produce the hydroxyl mycolate. mycolic acids represent a major constituent of the mycobacterial cell wall complex. methyl transfer results in formation of a secondary hydroxy group with an adjacent methyl branch; olefinic mycolic acid methyl transferase.
4552135	amidase, AmiD; Frame-shift
4552037	ceramidase; Frame-shift
4552038	conserved hypothetical protein; Frame-shift
4551907	PPE family protein; stop codon
4551527	N-term transposase for IS2606; disruption by insertion sequence; required for the transposition of the insertion element IS2606.
4551530	C-term PPE family protein; Truncated by IS2606 and IS2404 insertion
4551544	arylsulfatase AtsA; stop codon, frame shift mutation; thought to play an important role in the mineralization of sulfates [catalytic activity: a phenol sulfate + H2O = a phenol + sulfate]
4551339	conserved hypothetical protein; Frame shift
4550178	O-methyltransferase; Frame-shift
4550179	O-methyltransferase; stop codon; cellular metabolism
4553563	PPE family protein; Frame shift
4553564	conserved hypothetical membrane protein; stop codon; similar to other proteins involved in nucleotide transport
4553775	coenzyme F420-dependent oxidoreductase; frame shift mutation
4553777	C-term conserved hypothetical transmembrane protein; frame shift mutation
4553779	conserved hypothetical transmembrane protein; disruption by insertion sequence
4550861	conserved hypothetical protein; Truncated by IS2404 insertion; possible transcriptional regulator
4550866	PPE family protein; frameshift
4551639	inosine-uridine nucleoside hydrolase, IunH; Frame-shift; involved in purine salvage. catalyzes the hydrolysis of all of the commonly occurring purine and pyrimidine nucleosides into ribose and the associated base, and could have a preference for inosine and uridine as substrates [catalytic activity: a N-D-ribosylpurine + H(2)O = a purine + d- ribose]
4551644	conserved hypothetical protein; Frame-shift
4551646	conserved hypothetical protein; Frame-shift
4551647	conserved hypothetical membrane protein; disruption by insertion sequence and DNA deletion
4551653	conserved hypothetical protein; Frame-shift
4552191	conserved hypothetical protein
4552212	C-term glycosyl transferase; N-term at MUL_4527; Truncated N-term.  Missing first 189aa.; function unknown, probably involved in cellular metabolism
4552217	aldehyde dehydrogenase NAD dependent AldA_2; Frame shift mutation.; oxidizes a variety of aldehydes [catalytic activity: an aldehyde + NAD+ + H2O = an acid + NADH]
4552218	C-term transposase for IS2404; DNA deletion - missing the first 80 aa.; required for the transposition of insertion element IS2404.
4552795	PE-PGRS family protein; C-term truncated.  Missing approx 480aa.
4552797	Mid-section PE-PGRS family protein; disruption by insertion sequence
4552800	PE-PGRS family protein; N-term absent and C-term disrupted by premature stop codon and multiple IS insertions.
4552803	chalcone synthase Pks10_1; Frame shift mutation.  N-term truncated.; possibly involved in the biosynthesis of secondary metabolites [catalytic activity: 3 malonyl-CoA + 4- coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2]
4552806	oxidoreductase; N-term truncated. Frame shift mutation.
4552816	O-methyltransferase Omt_2; Frame shift mutation; function unknown, but supposed involved in lipid metabolism
4552835	PE-PGRS family protein; frame shift mutation
4552836	N-term PE-PGRS family protein; DNA deletion; function unknown. seems to influence both cell surface interactions among mycobacteria and the interactions of bacteria with macrophages.
4552837	transcriptional regulatory protein; N-term truncated.  Internal stop codon.; involved in transcriptional mechanism.
4552697	conserved hypothetical membrane protein; Frame shift mutation
4552698	conserved hypothetical protein; Truncated N-term (missing first 50aa) and truncated C-term (interupted by internal stop codon)
4552700	mid-section integral membrane nitrite extrusion protein NarK3_1; N-term disrupted by insertion element IS2606. Truncated c-term (missing last 200aa); involved in excretion of nitrite produced by the dissimilatory reduction of nitrate. responsible for the translocation of the substrate across the membrane.
4552701	N-term transposase for IS2404; DNA deletion - N-term 64 aa only.; required for the transposition of insertion element IS2404.
4552702	N-term PE family protein; Disrupted by IS2404 insertion
4552705	conserved hypothetical protein; Frame shift mutation
4553191	conserved hypothetical protein; N-term truncated due to internal stop codon.
4553192	conserved hypothetical protein; Frame shift mutation
4553193	conserved hypothetical protein; C-term truncated (missing last 50aa)  Frame shift muatation.
4553199	conserved hypothetical protein; Frame shift muatation.
4553201	dehydrogenase; C-term truncated by internal stop codon.; function unknown, probably involved in cellular metabolism
4553206	C-term zinc-type alcohol dehydrogenase (E subunit) AdhE; Truncated N-term.  Missing first 100aa.; dehydrogeneses a alcohol (oxido-reduction) [catalytic activity: an alcohol + NAD+ = an aldehyde or ketone + NADH]
4553210	fatty-acid-CoA ligase FadD5; Frame shift mutation.; function unknown, but involved in lipid degradation.
4553223	lipoprotein LprO; N-term truncated by internal stop codon.
4553225	conserved hypothetical protein; Frame shift mutation.
4553232	PE-PGRS family protein; frame shift mutation
4553238	oxidoreductase; Frame shift mutation; function unknown, probably involved in cellular metabolism.
4553515	conserved transmembrane protein; Frame shift mutation
4553522	fatty-acid-CoA ligase FadD4; C-term truncated by internal stop codon.; function unknown, but involved in lipid degradation.
4553525	acyl-CoA dehydrogenase FadE3_2; Disrupted N-term due to insertion element IS2404 (Missing 44aa)  Frame shift mutation; function unknown, but involved in lipid degradation.
4553528	conserved hypothetical protein; Truncated C-term due to internal stop codon.
4553530	conserved hypothetical membrane protein; frame shift mutation
4553534	conserved hypothetical protein; Truncated C-term due to internal stop codon. (First 77aa. only)
4553539	peptide synthetase Nrp; stop codon; involved in lipid metabolism.
4553548	PE-PGRS family protein; N-term disrupted by insertion element IS2404.; function unknown. seems to influence both cell surface interactions among mycobacteria and the interactions of bacteria with macrophages.
4553458	N-term transposase for IS2404; disruption by insertion sequence - N-term fragment of 64aa. only; required for the transposition of insertion element IS2404.
4553460	N-term cytochrome P450 125A6 Cyp125A6P; Disrupted C-term due to insertion sequence IS2404. See MUL_2964 for C-term.; cytochromes P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. note that C-term elsewhere on the chromosome (202aa) due to DNA rearrangement
4554018	N-term monooxygenase; see MUL_2963 for C-term; disruption by insertion sequence
4554042	C-term conserved integral membrane protein; N-term truncated by 126aa.
4554052	nitrite reductase [NAD(P)H] large subunit [fad flavoprotein] NirB; C-term truncated by internal stop codon.; involved in nitrate assimilation (denitrification) (at the second step) this enzyme is a fad flavoprotein that also contains a siroheme and one 2Fe-2S iron-sulfur center [catalytic activity: 3 NAD(P)H + nitrite = 3 NAD(P)+ + NH4OH + H2O]
4554057	integral membrane nitrite extrusion protein NarK3_2; Frame shift mutation; involved in excretion of nitrite produced by the dissimilatory reduction of nitrate. responsible for the translocation of the substrate across the membrane.
4554410	O-Methyltransferase; C-term disrupted by two internal stop codons (missing 111aa)
4554436	peptide synthetase; C-term is fused with a CDS encoding a hypothetical oxidase (In M. marinum M MMAR_3634, MON6242); frame shift mutation; function unknown role in production of a secondary metabolite
4554438	tryptophan halogenase; C-term truncated by internal stop codon.; tryptophan halogenase catalyses the chlorination of tryptophan to form 7-chlorotryptophan. this is the first step in the biosynthesis of pyrrolnitrin, an antibiotic with broad-spectrum anti-fungal activity. tryptophan halogenase is NADH-dependent.
4554441	conserved hypothetical membrane protein; C-term disrupted by insertion element IS2404. Frame shift mutation.
4554521	conserved hypothetical protein; C-term truncated.  Frame shift mutation
4554527	mid-section conserved transmembrane transport protein MmpL4; disruption by insertion sequence
4550123	N-term conserved transmembrane protein, MmpS5_2; stop codon
4550124	conserved hypothetical protein; C-term truncated (missing 114aa)  Frame shift mutation.
4550125	conserved hypothetical proline rich protein; Frame shift mutation.
4550709	C-term secreted unknown protein; N-term truncated (missing first 78aa)
4550727	C-term conserved hypothetical protein; N-term truncated by 281aa.
4551388	PE-PGRS family protein; Frame shift mutation; function unknown. seems to influence both cell surface interactions among mycobacteria and the interactions of bacteria with macrophages.
4551389	conserved hypothetical protein; N-term truncated by frame shift mutation (missing first 49aa)
4551393	conserved hypothetical protein; C-term truncated by 315aa.  Frame shift mutation.
4554077	N-term conserved hypothetical protein; C-term truncated (missing last 84aa)
4554086	drugs-transport transmembrane ATP-binding protein ABC transporter; C-term truncated by 415aa.  Frame shift mutation.; thought to be involved in active transport of drugs across the membrane (export): multidrugs resistance by an export mechanism. responsible for energy coupling to the transport system and for the translocation of the substrate across the membrane.
4551948	conserved hypothetical protein; N-term truncated by frame shift mutation.
4551954	transposase for IS2404; frame shift mutation; required for the transposition of insertion element IS2404.
4551956	mid-section peptide synthetase; Fragment.  C-term disrupted by insertion element IS2606. N-term truncated.; involved in lipid metabolism.
4551958	mid-section conserved MmpL4-like transmembrane transport protein; N-term truncated by 150aa. C-term disrupted by ISE; function unknown. thought to be involved in fatty acid transport.
4551959	C-term transposase for IS2404; DNA deletion - N-term truncated (missing 234 aa); required for the transposition of insertion element IS2404.
4552562	conserved hypothetical protein; N-term truncated (missing 63aa) by frame shift mutation.
4552537	PE-PGRS family protein; N-term (38aa) disrupted by insertion element IS2404. Frame shift mutation.
4552520	C-term conserved transmembrane transport protein MmpL4; N-term disrupted by insertion element IS2606 (missing 717aa); function unknown. thought to be involved in fatty acid transport.
4552524	conserved MmpL4-like transmembrane transport protein; Predicted to be a pseudogene but proteomic analysis of MU1615 suggests that the predicted 21.5 kDa protein is made.; N-term disrupted by insertion element ISE.  C-term disrupted by internal stop codon and ISE.; function unknown. thought to be involved in fatty acid transport. predicted to be a pseudogene but proteomic analysis of MU1615 suggests that the predicted 21.5 kDa protein is made.
4552529	peptidase; N-term interupted by internal stop codon.; function unknown, hydrolyzes peptides and/or proteins.
4552485	8-amino-7-oxononanoate synthase BioF2_4; N-term disrupted by insertion element IS2404 (missing 708aa); could be involved in biotin biosynthesis (at the first step) [catalytic activity: 6-carboxyhexanoyl-CoA + L- alanine = 8-amino-7-oxononanoate + CoA + CO2]
4552487	8-amino-7-oxononanoate synthase BioF1_1; N-term disrupted by IS2404 (missing 676aa)  C- term disrupted by frame shift mutation.; involved in biotin biosynthesis (at the first step) [catalytic activity: 6-carboxyhexanoyl-CoA + L-alanine = 8- amino-7-oxononanoate + CoA + CO2]
4552490	conserved transmembrane ATP-binding protein ABC transporter; N-term disrupted by frame shift mutation.; thought to be involved in active transport of undeterminated substrate (possibly lipooligosaccharide) across the membrane. responsible for energy coupling to the transport system and for the translocation of the substrate across the membrane.
4552491	oxidoreductase; N-term truncated (missing 118aa); function unknown, probably involved in cellular metabolism.
4552497	polyketide synthase; Frame shift; involved in unknown polyketide synthesis.
4552469	isocitrate dehydrogenase [NADP] Icd1; C-term truncated by frame shift mutation.; involved in the krebs cycle [catalytic activity: isocitrate + NADP(+) = 2-oxoglutarate + CO(2) + NADPH]
4552478	N-term PE-PGRS family protein; C-term truncated (missing 400aa)
4552479	alternative RNA polymerase sigma factor SigJ; C-term truncated by frame shift mutation.; the sigma factor is an initiation factor that promotes attachment of the RNA polymerase to specific initiation sites and then is released.
4552481	conserved hypothetical protein; N-term truncated by frame shift mutation.
4552482	C-term conserved hypothetical protein; disruption by insertion sequence - N-term missing 148 aa.
4552483	PE-PGRS family protein; C-term truncated by frame shift mutation.
4552455	conserved transmembrane protein; N-term truncated by internal stop codon.
4552468	PPE family protein; N-term disrupted by IS2606.  C-term truncated by IS2404 (missing last 94aa)
4552437	N-term nitrite extrusion protein 1 NarK1; C-term truncated (missing 437aa); involved in excretion of nitrite produced by the dissimilatory reduction of nitrate.
4552381	conserved hypothetical protein; FUNCTION UNKNOWN- frameshift. POSSIBLE EXPORTED CONSERVED PROTEIN
4552392	esterase, LipL; stop codon
4552363	glycosyl transferase; frame shift mutation; function unknown, contains partial Cdd pfam01209 ubiE/COQ5 methyltransferase family
4552364	nucleoside-diphosphate-sugar epimerase; contains Cdd COG0451 nucleoside-diphosphate-sugar epimerases [cell envelope biogenesis, outer membrane - carbohydrate transport and metabolism]
4552369	conserved hypothetical; frame shift mutation
4552373	methylase; stop codon; function unknown, domain identity to UbiG, 2- polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylases
4552345	conserved hypothetical protein; frame shift mutation; function unknown.
4552354	fatty acyl-CoA reductase; frame shift mutation; thought to reduce acyl-CoA esters of fatty acids to fatty aldehydes.
4552317	conserved hypothetical protein; N-term disrupted by insertion element IS2606.
4552319	cyanophycinase CphB; N-term disrupted by insertion element IS2404.; function unknown, possibly involved in secondary metabolites biosynthesis, transport, and catabolism / inorganic ion transport and metabolism.
4552108	UDP-N-acetylmuramyl tripeptide synthase; frame shift mutation
4552109	anchored-membrane serine/threonine-protein kinase PknF_1; N-term disrupted by 2 internal stop codons.; involved in signal transduction (via phosphorylation) thought to be involved in membrane transport. phosphorylates the peptide substrate myelin basic protein (MBP) at serine and threonine residues [catalytic activity: ATP + a protein = ADP + a phosphoprotein]
4552110	ionic transporter integral membrane protein ChaA; C-term interupted (missing 53aa) by internal stop codon.; involved in transport of ions (presumably calcium) across the membrane. responsible for the translocation of the substrate across the membrane.
4552117	prolipoprotein diacylglyceryl transferases Lgt; Frame shift mutation.; prolipoprotein modification
4552090	integral membrane cytochrome D ubiquinol oxidase (subunit I) CydA; N-term disrupted by internal stop codon.; involved in the respiratory chain (at the terminal step): aerobic respiration. cytochrome D terminal oxidase complex is the component of the aerobic respiratory chain that is supposed predominated when cells are grown at low aeration [catalytic activity: ubiquinol-8 + O(2) = ubiquinone-8 + H(2)O]
4552092	membrane-anchored adenylyl cyclase Cya; Frame shift mutation.; involved in camp synthesis [catalytic activity: ATP = 3',5'-cyclic AMP + diphosphate]
4552095	nonspecific lipid-transfer protein; Frame shift mutation; thought to be involved in lipid metabolism.
4552072	transmembrane serine/threonine-protein kinase; N-term disrupted by internal stop codon.; involved in signal transduction (via phosphorylation) [catalytic activity: ATP + a protein = ADP + a phosphoprotein]
4552086	PE-PGRS family protein; C-term disrupted by insertion element IS2404 (missing 377aa)
4552065	chalcone synthase, Pks10; frame shift mutation; possibly involved in the biosynthesis of secondary metabolites [catalytic activity: 3 malonyl-CoA + 4- coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2]
4552066	polyketide synthase Pks7; stop codon, frame shift mutation; function unknown, contains partial Cdd pfam00109, ketoacyl-synt, beta-ketoacyl synthase, N-terminal domain.
4552067	polyketide synthase, Pks8; frame shift mutation; function unknown. mycocerosic acid synthase like. contains partial Cdd pfam00109, ketoacyl-synt, beta- ketoacyl synthase, N-terminal domain.
4552070	cytochrome P450 139A3 Cyp139A3P; frame shift mutation; cytochromes P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics
4551935	PE-PGRS family protein; frame shift mutation
4551944	PE-PGRS family protein; frame shift mutation
4551946	PE_PGRS family protein; frame shift mutation
4551912	N-term conserved hypothetical protein; DNA deletion; function unknown, appears to be truncated at both N- terminal and C-terminal ends compared with Rv1375 and M. marinum orthologue
4551877	conserved hypothetical protein; frame shift mutation
4551881	multidrug resistance membrane efflux protein EmrB_2; frame shift mutation; involved in transport of multidrug across the membrane (export): multidrug resistance by an export mechanism. responsible for the translocation of the substrate across the membrane.
4551884	nonribosomal peptide synthetase; frame shift mutation; involved in the non-ribosomal synthesis of peptides. contains Cdd pfam00975, thioesterase; pfam00550,phosphopantetheine attachment site and C- terminal partial Cdd pfam00501, AMP-binding, AMP-binding enzyme.
4551866	PE-PGRS family protein; Unknown. Contains signal peptide
4551829	conserved 13E12 repeat family protein; May be regulated by LexA; frame shift mutation
4551831	conserved hypothetical protein; stop codon
4551834	conserved hypothetical protein; frame shift mutation; contains partial (N-terminal) Cdd pfam00596, aldolase_II, class II aldolase and adducin N-terminal domain.
4551840	conserved hypothetical protein; stop codon
4551841	transmembrane alanine and valine and leucine rich protein; frame shift mutation
4551797	conserved hypothetical protein; frame shift mutation
4551732	amino acid decarboxylase; frame shift mutation; function unknown. could be an ornithine/arginine/lysine decarboxylase involved in the biosynthesis of spermidine from arginine.
4551741	NodS-like (SAM)-dependent methyltransferase; DNA deletion; function unknown, first 35 aa absent WRT to M. marinum orthologue, possibly due to DNA deletion
4551707	long-chain-fatty-acid--CoA ligase FadD12; Frame shift mutation.; function unknown, but supposed involvement in lipid degradation.
4551676	conserved hypothetical membrane protein; Frame shift mutation
4551682	4-aminobutyrate aminotransferase GabT_1; Frame shift mutation.; involved in 4-aminobutyrate (GabA) degradation pathway [catalytic activity: 4-aminobutanoate + 2- oxoglutarate = succinate semialdehyde + L-glutamate]
4551683	cationic amino acid transport integral membrane protein; N-term interupted by an internal stop codon.; thought to be involved in cationic amino acid transport across the membrane. responsible for the translocation of the substrate across the membrane.
4551667	C-term transposase for IS2404; DNA deletion - N-term truncated by 153 aa.; required for the transposition of insertion element IS2404.
4551670	transposase for IS2404; Frame shift mutation; required for the transposition of insertion element IS2404.
4551671	trehalose-6-phosphate phosphatase OtsB1; C-term disrupted by insertion element IS2404.; involved in trehalose biosynthesis (protective effect) mycobacteria can produce trehalose from glucose 6- phosphate and UDP-glucose (the OtsA-OtsB pathway) from glycogen-like alpha(1-->4)-linked glucose polymers (the TreY-TreZ pathway) and from maltose (the TreS pathway) seems to have additional alpha-glucosidase activity.
4551575	PE-PGRS family protein; frame shift mutation
4551578	N-term conserved hypothetical protein; C-term truncated by 50 aa.
4551579	C-term conserved hypothetical protein; N-term truncated by insertion element IS2404 (missing 28aa)
4551545	C-term PPE family protein; disruption by insertion sequence
4551559	N-term transcriptional regulatory protein; C-term disrupted by IS2404 (missing last 22aa); involved in transcriptional mechanism.
4551510	formate hydrogenase HycE; C-term truncated (missing 317aa) Involved in a 3 part frame shift mutation.; involved in hydrogen metabolism; FHL pathway.
4551525	penicillin-binding protein; stop codon; thought to be involved in cell wall biosynthesis and may also act as a sensor of external penicillins
4551492	conserved hypothetical protein; frame shift mutation
4551494	N-term conserved hypothetical membrane protein; DNA deletion
4551503	conserved hypothetical protein; stop codon
4551272	methyltransferase; disruption by insertion sequence; causes methylation.
4551277	transmembrane transport protein MmpL4_9; stop codon; function unknown. thought to be involved in fatty acid transport.
4551283	C-term oxidoreductase; DNA deletion; function unknown, probably involved in cellular metabolism.
4551259	alanine rich dehydrogenase; frame shift mutation; function unknown, probably involved in cellular metabolism.
4551262	C-term conserved integral membrane transport protein; DNA deletion?; function unknown, missing first 25 aa; contains major facilitator superfamily (MFS) the MFS transporters are single-polypeptide secondary carriers capable only of transporting small solutes in response to chemiosmotic ion gradients.
4551269	C-term conserved transmembrane transport protein MmpL1; disruption by insertion sequence; function unknown. thought to be involved in fatty acid transport.
4551200	N-term oxidoreductase; DNA deletion; thought to be involved in fatty acid degradation. FadB and FadA are the alpha and BetA subunits of the multifunctional enzyme complex of the fatty acid degradation cycle.
4551203	C-term conserved hypothetical alanine rich membrane protein; DNA deletion
4551167	conserved hypothetical secreted protein; stop codon
4551174	C-term methyltransferase; DNA deletion; thought to cause methylation.
4551177	C-term formyltetrahydrofolate deformylase PurU; DNA deletion; involved in de novo purine biosynthesis [catalytic activity: 10-formyltetrahydrofolate + H(2)O = formate + tetrahydrofolate]
4551179	glycosyl transferase; stop codon; involved in PGL biosynthesis. in M. tuberculosis H37Rv, the product of the mu orthologue (Rv2962c) catalyzes the transfer of a rhamnosyl residue onto p- hydroxybenzoic acid ethyl ester or phenolphthiocerol dimycocerosates.
4551182	ketoreductase; stop codon; KR involved in the conversion of phthiodiolones to phthiocerols
4551086	ammonium-transport integral membrane protein Amt; frame shift mutation; thought to be involved in transport of ammonium across the membrane (export) responsible for the translocation of the substrate across the membrane.
4551088	[protein-PII] uridylyltransferase GlnD; frame shift mutation; modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein [catalytic activity: UTP + [protein-PII] = diphosphate + uridylyl-[protein-PII]]
4551070	conserved hypothetical protein; frame shift mutation
4551020	conserved hypothetical protein; stop codon
4551023	L-lactate dehydrogenase (cytochrome) LldD1_1; frame shift mutation; involved in respiration; catalyzes conversion of lactate into pyruvate [catalytic activity: (S)-lactate + 2 ferricytochrome C = pyruvate + 2 ferrocytochrome C]
4551025	C-term conserved hypothetical protein; DNA deletion
4551036	C-term transposase for IS2404; DNA deletion - N-term truncated by 112 aa.; required for the transposition of insertion element IS2404.
4551005	major secreted immunogenic protein Mpt70; disruption by insertion sequence
4550984	PPE family protein; stop codon
4550985	C-term PE-PGRS family protein; DNA deletion
4550986	C-term 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase AroG; DNA deletion; chorismate biosynthesis
4550988	pseudogene; N terminal 44aa of 8-amino-7-oxononanoate synthase BioF2_3 {MMAR_1852}
4550989	N-term conserved transmembrane transport protein MmpL4_8; DNA deletion; function unknown. thought to be involved in fatty acid transport.
4550991	drug-transport integral membrane protein; frame shift mutation; thought to be involved in transport of drug across the membrane (export): drug resistance by an export mechanism (conferes resistance to toxic compounds by removing them for the cells) responsible for the translocation of the substrate across the membrane.
4550955	N-term SN-glycerol-3-phosphate transport integral membrane protein ABC transporter UgpE; disruption by insertion sequence; involved in active transport of SN-glycerol-3- phosphate across the membrane (import) responsible for the translocation of the substrate across the membrane.
4550958	C-term conserved hypothetical protein; DNA deletion
4550959	conserved hypothetical protein; frame shift mutation
4550960	trehalose and maltose hydrolases; stop codon; function unknown but may be involved in trehalose biosynthesis. mycobacteria can produce trehalose from glucose 6-phosphate and UDP-glucose (the OtsA-OtsB pathway) from glycogen-like alpha(1-->4)-linked glucose polymers (the TreY-TreZ pathway) and from maltose (the TreS pathway) seems to have additional alpha-glucosidase activity.
4550928	conserved hypothetical protein; stop codon
4550942	zinc protease PepR; disruption by insertion sequence; function unknown, possibly hydrolyzes peptides and/or proteins
4550820	short-chain dehydrogenase EphD_1; frame shift mutation; thought to be involved in detoxification reactions following oxidative damage to lipids.
4550825	conserved hypothetical protein; stop codon
4550829	C-term conserved hypothetical dehydrogenase; DNA deletion
4550831	chain-fatty-acid-CoA ligase FadD13_1; frame shift mutation; function unknown, but involved in lipid degradation.
4550832	N-term PPE family protein; disruption by insertion sequence
4550640	bifunctional protein acetyl-/propionyl-coenzyme a carboxylase (alpha chain) AccA3_1; frame shift mutation; involved in long-chain fatty acid synthesis (at the first step) carries two functions: biotin carboxyl carrier protein and biotin carboxyltransferase [catalytic activity: ATP + biotin-carboxyl-carrier protein + CO(2) = ADP + orthophosphate + carboxybiotin-carboxyl-carrier protein]
4550641	PE-PGRS family protein
4550643	acyl-CoA dehydrogenase FadE34_1; disruption by insertion sequence; function unknown, but involved in lipid degradation.
4550650	type I restriction/modification system DNA methylase HsdM; frame shift mutation; implicated in methylation of DNA. component of type I restriction/modification system. it is possible that the M and S subunits together form a methyltransferase (MTase) that methylates two adenine residues in complementary strands of bipartite DNA recognition sequence.
4550651	type I restriction/modification system specificity determinant HsdS (S protein); stop codon; implicated in restriction/modification of DNA. component of type I restriction/modification system. it is thought that the M and S subunits together form a methyltransferase (MTase) that methylates two adenine residues in complementary strands of bipartite DNA recognition sequence.
4550656	N-term conserved hypothetical membrane protein; disruption by insertion sequence
4550628	N-term conserved hypothetical protein; disruption by insertion sequence
4550629	fatty-acid-CoA ligase FadD9; disruption by insertion sequence; function unknown, but involved in lipid degradation.
4550633	C-term conserved hypothetical protein; DNA deletion
4550637	PPE family protein; frame shift mutation
4550638	1-aminocyclopropane-1-carboxylate deaminase; frame shift mutation; amino acid transport and metabolism
4550606	HrpA-like helicases; N-term missing first 90aa.  C-term disrupted by internal stop.; possibly has helicase activity.
4550607	N-term PE-PGRS family protein; DNA deletion
4550611	C-term carbohydrate kinase; DNA deletion; phosphorylation of carbohydrates
4550612	conserved hypothetical transmembrane protein; frame shift mutation
4550618	conserved hypothetical protein; disruption by insertion sequence
4550621	C-term dehydrogenase fad flavoprotein Gmc oxidoreductase; DNA deletion; function unknown, probably involved in cellular metabolism, probably electron-transfer-linked.
4550622	C-term conserved two-domain membrane protein; DNA deletion; function unknown, but seems involved in efflux system (probably sugar or drug transport)
4550590	O-methyltransferase; DNA deletion,frame shift mutation
4550591	conserved hypothetical membrane protein; frame shift mutation; function unknown. thought to be involved in virulence.
4550593	C-term heat shock protein transcriptional repressor HspR_2; disruption by insertion sequence; involved in transcriptional regulation (repression) of heat shock proteins E.G. DnaK, GrpE, DnaJ. binds to three inverted repeats (IR1-IR3) in the promoter region of the DnaK operon. induction: by heat shock.
4550599	C-term ferredoxin FdxA; DNA deletion; involved in electron transfer.
4550571	EsaT-6 family, EsxS; frame shift mutation
4550575	PPE family protein; frame shift mutation
4550582	sugar-binding lipoprotein; frame shift mutation
4550583	conserved hypothetical protein; Frame-shift
4550587	conserved hypothetical protein; Frame-shift
4550525	adenylate cyclase; frame shift mutation
4550530	conserved transmembrane transport protein MmpL4_7; Frame-shift. Belongs to the drug export RND superfamily
4550484	C-term PPE family protein
4550485	conserved hypothetical protein; Interrupted by IS2404
4550493	conserved hypothetical protein; frame shift mutation
4550455	peptide synthetase; disruption by insertion sequence
4550458	polyketide synthase; IS insertion and frame-shift mutation
4550459	N-term polyketide synthase and peptide synthetase; DNA deletion; function unknown: a single module PKS/NRP that may have been part of a larger NRP-PKS-NRP fusion synthase complex. The predicted module and domain arrangement of this hybrid synthase is:    M1: Nrp (condensation domain, adenylation/substrate domain, ACP)  M2: PKS (KS, ATProp, DH, ER, KR, ACP)  M3: NRP (condensation domain, adenylation/substrate domain, ACP, TE)
4550431	PPE family protein; frame shift mutation
4550432	C-term 5-methyltetrahydrofolate--homocysteine methyltransferase MetH_1; DNA deletion, last 40 aa only; involved in biosynthesis of methionine (at the terminal step) [catalytic activity: 5- methyltetrahydrofolate + L-homocysteine = tetrahydrofolate + L-methionine]
4550415	C-term integrase; DNA deletion; remnant of prophage integrase, element still present in M. marinum 'M' strain.
4550418	C-term transposase (IS3 family); Partial sequence only
4550420	transposase; Partial sequence
4550422	conserved transmembrane transport protein MmpL4_5; stop codon; function unknown. thought to be involved in fatty acid transport.
4550425	non-ribosomal peptide synthetase fragment
4550376	conserved hypothetical protein; Product confirmed by proteomics in M. ulcerans strain 1615.
4550356	alkyldihydroxyacetonephosphate synthase AgpS; Frame-shift mutation; involved in ether lipid biosynthesis [catalytic activity: 1-acyl-glycerone 3-phosphate + a long-chain alcohol = 1-alkyl-glycerone 3-phosphate + a long-chain acid anion]
4550316	conserved hypothetical protein; frame shift mutation
4550320	acyl-CoA dehydrogenase FadE12_3; Frame-shift; function unknown, but involved in lipid degradation.
4550326	membrane-associated phospholipase C PlcB_2; Frame shift mutation; hydrolyzes sphingomyelin in addition to phosphatidylcholine. probable virulence factor implicated in the pathogenesis of mycobacterium tuberculosis at the level of intracellular survival, by the alteration of cell signaling events or by direct cytotoxicity [catalytic activity: a phosphatidylcholine + H(2)O = 1,2- diacylglycerol + choline phosphate]
4550310	PPE family protein; disruption by insertion sequence
4550260	conserved hypothetical protein
4550277	methylisocitrate lyase 2; Frame shift mutation
4550076	conserved hypothetical protein; frame shift mutation
4550058	conserved hypothetical protein
4550059	conserved hypothetical protein; frame shift mutation
4550028	conserved transmembrane transport protein; Frame shift mutation; function unknown, but seems involved in efflux system (probably sugar or drug transport)
4550037	PPE family protein; Disrupted by IS2404 insertion
4550040	C-term PE family protein; DNA deletion
4550041	C-term PE_PGRS protein; DNA deletion
4549872	transmembrane alkane 1-monooxygenase AlkB; Potential pseudogene due to frame-shift mutation; thought to be involved in fatty acid metabolism. generates octanol and oxidized rubredoxin from octane and reduced rubredoxin. also hydroxylates fatty acids in the omega-position [catalytic activity: octane + reduced rubredoxin + (O)2 = 1-octanol + oxidized rubredoxin + H(2)O]
4549856	acyl esterase; stop codon
4549859	transmembrane carbonic anhydrase; Frame shift mutation; generates CO(2) and H(2)O from H(2)CO(3), and possibly involved in transport of sulfate across the membrane.
4549848	ATP-dependent helicase Lhr; LARGE HELICASE-RELATED PROTEIN. FRAME SHIFT; function unknown but has both ATPase and helicase activities.
4549784	magnesium and cobalt transport transmembrane protein CorA_1; stop codon; thought to be involved in transport of magnesium and cobalt ions across the membrane. responsible for the translocation of the substrate across the membrane.
4549786	metal cation transporting p-type ATPase CtpH_1; Frame shift mutation; metal cation-transporting ATPase; possibly catalyzes the transport of undeterminated metal cation with hydrolyse of ATP [catalytic activity: ATP + H(2)O + undeterminated metal cation(in) = ADP + phosphate + undeterminated metal cation(out)]
4549787	N-terminal conserved hypothetical protein
4549788	C-terminal conserved hypothetical protein
4549772	PE-PGRS family protein; frame shift mutation
4549695	C-term ferredoxin-dependent nitrite/sulphite reductase NirA; DNA deletion; N-term truncated compared with orthologues (missing 80 aa lost by DNA deletion) generates nitrite from ammonia using oxidized ferredoxin. [catalytic activity: ammonia + H(2)O + oh(-) + 3 oxidized ferredoxin = nitrite + 3 reduced ferredoxin] the sulfite reductases catalyze the reduction of sulfite to sulfide, one step in the biosynthesis of sulfur-containing amino acids and cofactors.
4549673	conserved hypothetical protein; Frame-shift
4549674	conserved integral membrane transport protein YjcE; Disrupted by IS2404 insertion; possibly involved in transport of Na+/H+ across the membrane.
4549677	hydroxylase; Frame shift; function unknown but contains identity with hydroxylase domain
4549680	C-term hypothetical protein; DNA deletion
4552885	conserved hypothetical protein; stop codon, frame shift mutation
4552886	transposase; frame shift mutation; involved in the transposition of an insertion sequence. transposase, possibly made by frameshifting.
4552887	transposase; stop codon
4552888	conserved hypothetical protein; Disrupted by IS2404 insertion
4552894	C-term conserved hypothetical protein; DNA deletion, stop codon
4552897	conserved hypothetical membrane protein
4552906	maltooligosyltrehalose synthase TreX_1; disruption by insertion sequence; possibly involved in trehalose biosynthesis (protective effect) mycobacteria can produce trehalose from glucose 6-phosphate and UDP-glucose (the OtsA-OtsB pathway) from glycogen-like alpha(1-->4)-linked glucose polymers (the TreY-TreZ pathway) and from maltose (the TreS pathway) C-term truncated by IS2606 insertion
4552913	short-chain dehydrogenase; Frame shift mutation
4552916	N-term conserved hypothetical membrane protein; DNA deletion
4552918	C-term amidotransferase family protein; DNA deletion
4552925	N-terminal conserved hypothetical membrane protein
4552930	transcriptional regulatory protein EmbR_1; Frameshift mutation; involved in transcriptional mechanism. thought to regulate the biosynthesis of the mycobacterial cell wall arabinan and resistance to ethambutol (Emb; dextro-2,2'- (ethylenediimino)-di-1-butanol), regulating EmbA and EmbB.
4552931	C-term PPE family protein; Truncated by IS2404 insertion
4552948	C-term regulatory protein; Truncated by IS2404 insertion
4552953	conserved hypothetical membrane protein; Frame shift mutation
4552968	N-term conserved hypothetical proline-rich protein; DNA deletion
4552969	C-term conserved hypothetical protein; Fragment only. Partial match to MAP3903c
4552981	phosphate acetyltransferase Pta; Frame shift mutation (PHOSPHOTRANSACETYLASE); involved at the last step (of two) in the conversion of acetate to acetyl-CoA [catalytic activity: acetyl-CoA + phosphate = CoA + acetyl phosphate]
4552984	polyketide synthase Pks6; Frame-shift mutation; polyketide synthase involved in synthesis of unknown polar lipid
4552985	C-term conserved transmembrane transport protein MmpL1_1; Site of a genome deletion that removed the N-term of this orf and that of the adjacent, divergently transcribed pks6; function unknown. thought to be involved in fatty acid transport.
4552986	FMNH2-utilizing oxygenase; frame shift mutation; function unknown: involved in energy production and conversion
4552987	coenzyme F420-dependent reductase; frame shift mutation
4552988	C-term conserved hypothetical oxidoreductase; Disrupted by IS2404 insertion
4552990	mid-term conserved hypothetical oxidoreductase; Disrupted by IS2404 insertion; function unknown, probably involved in cellular metabolism.
4552994	acyl-CoA dehydrogenase FadE20_1; frame shift mutation; function unknown, but involved in lipid degradation.
4552997	N-term flavin-containing (mono)amine oxidase AofH_2; Truncated by IS2404 insertion; possibly catalyzes the oxidative deamination: oxidize on primary amines, and perhaps on secondary and tertiary amines [catalytic activity: RCH(2)NH(2) + H(2)O + O(2) = RchO + NH(3) + H(2)O(2)] must have important function in metabolism. supposed involved in stationary- phase survival.
4553030	N-term fatty-acid-CoA ligase FadD29_1; C-term truncated by IS2404 insertion; function unknown, but involved in lipid degradation.
4553041	C-term conserved hypothetical membrane protein; disruption by insertion sequence; function unknown; some similarity to MUP015c from pMUM001
4553045	beta-1,3-glucanase precursor; stop codon; possibly hydrolyzes specific sugar (hydrolyzation of glycosidic bond) and could be involved in exopolysaccharide biosynthesis/degradation. could also have a lytic activity against cell walls.
4553048	conserved hypothetical protein; frame shift mutation
4553100	MCE-family protein Mce3C; stop codon; function unknown, but thought to be involved in host cell invasion.
4553102	MCE-family protein Mce3A; stop codon; function unknown, but thought to be involved in host cell invasion.
4553107	cytochrome P450 278A1 Cyp278A1P; Detected in the membtrane fraction by proteomics in strain MU 1615; frame shift mutation; cytochromes P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
4553313	conserved hypothetical membrane protein
4553320	enoyl-CoA hydratase EchA13; stop codon; may oxidize fatty acids using specific components (by similarity) [catalytic activity: (3S)-3-hydroxyacyl- CoA = trans-2(or 3)-enoyl-CoA + H(2)O]
4553326	mid section conserved hypothetical protein; Similar to MUL2218
4553329	short-chain fatty acid transporter; Disrupted by IS2404 insertion
4553332	conserved hypothetical protein; Frame shift mutation
4553337	short-chain type dehydrogenase/reductase; Frame shift mutation; function unknown, probably involved in cellular metabolism.
4553347	phosphotransferase; frame shift mutation; this family consists of bacterial antibiotic resistance proteins, which confer resistance to various aminoglycosides.
4553349	conserved hypothetical protein; Frame shift mutation
4553351	C-term conserved hypothetical protein; Missing N-term (280aa) based on match with MAP1627
4553418	C-term conserved hypothetical protein; N-term missing 60aa compared with orthologues
4553422	PPE family protein; frame shift mutation
4553423	conserved hypothetical membrane protein; Frame shift
4553426	C-term conserved lipoprotein; Missing first 150aa
4553429	conserved hypothetical protein; frame shift mutation
4553438	C-term monooxygenase; see MUL_1146 for N-term; disruption by insertion sequence; function unknown, involved in cellular metabolism.
4553439	C-term cytochrome P450 125A6 Cyp125A6P; Disrupted N-term due to insertion sequence IS2404. See MUL_1139 for N-term.; cytochromes P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
4553445	hypothetical protein; stop codon
4553579	amidase; stop codon; function unknown, involved in cellular metabolism.
4553581	glutamine synthetase GlnA3; Disrupted by IS2404 insertion; involved in glutamine biosynthesis [catalytic activity: ATP + L-glutamate + NH(3) = ADP + glutamine + orthophosphate]
4553582	transposase for IS2404; frame shift mutation; required for the transposition of insertion element IS2404.
4553620	acyl-CoA transferase/dehydratase; stop codon; function unknown, but supposed involvement in lipid metabolism.
4553641	conserved hypothetical membrane protein; N-term truncated, missing first 60aa compared with orthologues and frame shift mutation
4553665	conserved hypothetical membrane protein; stop codon
4553666	N-term conserved hypothetical membrane protein; C-terminal (260aa) encoded by MUL_3057; DNA deletion
4553679	PE-PGRS family protein; stop codon
4553685	C-term conserved hypothetical protein; disruption by insertion sequence
4553686	N-term transposase for IS2404; DNA deletion; required for the transposition of insertion element IS2404.
4553692	conserved hypothetical protein; Disrupted by IS2404 insertion
4553702	PPE family protein; Frame-shift mutation
4553735	hypothetical protein; frame shift mutation
4553741	mid-section conserved hypothetical protein; DNA deletion
4553743	conserved hypothetical protein; stop codon
4553745	C-term isochorismatase family protein; First 125aa of 215aa absent; function unknown but this protein family are hydrolase enzymes
4553746	PE-PGRS family protein; Frame shift
4553748	oxidoreductase; Internal stop codon; function unknown, probably involved in cellular metabolism
4553809	conserved hypothetical protein; Frame shift mutation
4553812	conserved hypothetical protein; Frame-shift
4553820	PE-PGRS family protein; frame shift mutation
4553845	PE-PGRS family protein; Frame shift mutation
4553847	transcriptional regulatory protein; Frame shift mutation; involved in transcriptional mechanism.
4553849	mid portion conserved hypothetical secreted protein; function unknown but contains signal peptide sequence
4553850	fatty-acid-CoA ligase FadD1; frame shift mutation; function unknown, but supposed involvement in lipid metabolism.
4553853	flavin-binding monooxygenase; stop codon; function unknown, involved in cellular metabolism.
4553871	of conserved hypothetical protein
4553875	N-term fatty-acid-CoA ligase FadD13; Site of DNA deletion causing loss of 70 aa (C-term) and in-frame couplingwith adjacent d/s sequence. This has resulted in overlapping, divergently transcribed CDS. Both of these CDS have been annotated as pseudogenes; function unknown, but involved in lipid degradation.
4553876	N-term PE-PGRS family protein; Site of possible DNA deletion. First 195 aa of 500 aa protein present only.
4553877	conserved hypothetical membrane protein; frame shift mutation
4554110	metal cation transporter p-type ATPase a, CtpF; stop codon; metal cation-transporting ATPase; possibly catalyzes the transport of a undeterminated metal cation with the hydrolyse of ATP [catalytic activity: ATP + H(2)O + undeterminated metal cation(in) = ADP + phosphate + undeterminated metal cation(out)]
4554112	serine/threonine-protein kinase transcriptional regulatory protein PknK; Frame shift mutation; involved in signal transduction (via phosphorylation) involved in transcriptional regulatory mechanism and in the regulation of secondary metabolites [catalytic activity: ATP + a protein = ADP + a phosphoprotein]
4554120	carbohydrate phosphorylase; Frame shift; the members of this family catalyse the formation of glucose 1-phosphate from one of the following polyglucoses; glycogen, starch, glucan or maltodextrin.
4554163	conserved hypothetical protein; Frame shift
4554167	PE-PGRS family protein; Frame shift
4554169	C-term conserved transmembrane protein; disruption by insertion sequence
4554196	type I restriction-modification system restriction subunit; Frame-shift
4554199	C-term restriction endonuclease S subunit; N-term absent
4554200	type I restriction/modification system DNA methylase; Possible frame shift mutation
4554202	N-term fragment of type I restriction/modification system DNA methylase; Disrupted by IS2606
4554204	N-term transposase for IS2404; C-term truncated by second IS2404 insertion; required for the transposition of insertion element IS2404.
4554205	C-term conserved hypothetical protein; N-term (330 aa) absent of a putative protein (MUP070c) that is present in full on the MU plasmid, pMUM001.
4554219	PE-PGRS family protein; Frame shift
4554221	PE-PGRS family protein; frame shift mutation
4554235	C-term oxidoreductase; Missing at least 60 aa (N-term) wrt orthologues
4554237	conserved hypothetical protein; stop codon; function unknown but contains pfam03060 domain, NPD, 2-nitropropane dioxygenase. members of this family catalyse the denitrification of a number of nitroalkanes using either fad or FMN as a cofactor.
4554245	C-term conserved hypothetical protein; DNA deletion
4554247	hypothetical protein; stop codon
4554249	C-term conserved hypothetical protein; N-term missing 136 aa wrt Rv2627c. Site of possible DNA deletion.
4554273	N-terminal PE-PGRS family protein; DNA deletion
4554276	conserved hypothetical protein; Frame shift mutation
4554283	arsenic-transport integral membrane protein ArsC; Frame-shift; involved in transport of arsenic compounds across the membrane (export): arsenic resistance by an export mechanism. responsible for the translocation of the substrate across the membrane.
4554285	C-term transposase for IS2404; Missing N-term (63 aa) Truncated by second IS2404 insertion.; required for the transposition of insertion element IS2404.
4554292	amino acid transporter; Frame shift; thought to be involved in transport of amino acids across the membrane.
4554320	C-term conserved hypothetical membrane protein; N-term absent (116 aa) probably due to u/s DNA deletion (first 30 aa) and subsequent mutations in remaining sequence; therefore potential pseudogene
4554330	1-deoxy-D-xylulose 5-phosphate synthase Dxs1A; Frame shift mutation; involved in the deoxyxylulose-5-phosphate pathway (DXP) of isoprenoid biosynthesis (at the first step), and in the biosynthetic pathway to thiamine and pyridoxol (at the first step) catalyzes the acyloin condensation reaction between atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5- phosphate (DXP)
4554448	arsenic-transport integral membrane protein ArsB1; stop codon; thought to be involved in transport of arsenical compounds across the membrane (export): arsenic resistance by an export mechanism. responsible for the translocation of the substrate across the membrane.
4554449	antibiotic-transport integral membrane leucine, alanine and valine rich protein ABC transporter; Frame shift; thought to be involved in active transport of unidentified antibiotic across the membrane (export): antibiotic resistance by an export mechanism. responsible for the translocation of the substrate across the membrane.
4554451	antibiotic-transport ATP-binding protein ABC transporter; Premature stop codon in u/s orf has split this CDS into 2 parts.; thought to be involved in active transport of unidentified antibiotic across the membrane (export): antibiotic resistance by an export mechanism. responsible for energy coupling to the transport system.
4553177	PE-PGRS family protein; frame shift mutation
4553186	conserved hypothetical protein; Premature stop codon in u/s orf has split this into a second orf (wrt orthologues)
4553488	conserved hypothetical integral membrane protein; Disrupted by IS2404 insertion - removed C-term 122 aa.
4553489	transposase for IS2404; Two internal stop codons have split this orf into three parts; required for the transposition of insertion element IS2404.
4553496	conserved hypothetical membrane protein; Frame shift
4551980	C-term conserved hypothetical protein; Disrupted by IS2404 insertion
4553984	N-term PPE family protein; disruption by insertion sequence
4553993	transcriptional regulatory protein; Frame shift; involved in transcriptional mechanism.
4554094	N-term conserved hypothetical protein; frame shift mutation
4554099	carbon starvation protein a homolog CstA; Frame shift has removed 16 aa from N-term; peptide utilization during carbon starvation.
4554481	conserved hypothetical protein; Premature stop codon wrt to MTB orthologue
4554485	N-term PE-PGRS family protein; disruption by insertion sequence
4554488	PE-PGRS family protein; stop codon, frame shift mutation
4554490	hypothetical protein; frame shift mutation
4553261	conserved hypothetical membrane protein; N-term also truncated by IS insertion; disruption by insertion sequence, frame shift mutation; May play a role in cell division and chromosome partitioning
4553266	conserved hypothetical protein; Frame-shift
4553270	dehydrogenase; frame shift mutation; function unknown, probably involved in cellular metabolism
4553271	conserved hypothetical protein; Frame shift
4553274	hypothetical protein; frame shift mutation
4552760	conserved hypothetical protein; stop codon; function unknown but shares esterase domain identity
4552763	short-chain type dehydrogenase/reductase; N-term missing (70 aa); function unknown, possibly involved in cellular metabolism.
4552766	C-term conserved hypothetical protein; Unknown contains C-term of lysine decarboxylase domain
4552769	conserved hypothetical protein; Frame shift
4552771	conserved hypothetical oxidoreductase; frame shift mutation
4552254	PPE family protein; Frame shift
4552257	C-term PE-PGRS family protein; Disrupted by IS2404 insertion; may have triacylglycerol lipase activity. generates diacylglycerol and a fatty acid anion from triacylglycerol [catalytic activity: triacylglycerol + H(2)O = diacylglycerol + a fatty acid anion]
4552260	N-term transposase
4552261	transposase; frame shift mutation
4552262	transposase; involved in the transposition of an insertion sequence.
4552668	hydroxymethylglutaryl-coenzyme a synthase, PksG; Stop codon; part of the mevalonate pathway for isoprenoid synthesis: conversion: acetyl-CoA + H(2)O + acetoacetyl- CoA <=> (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
4552673	isopentenyl-diphosphate delta-isomerase Idi; Disrupted by IS2404 insertion; isoprenoid synthesis: converts isopentenyl diphosphate to dimethylallyl diphosphate
4552675	polyprenyl synthetase IdsB_1; stop codon; involved in biosynthesis of membrane ether-linked lipids. catalyzes the trans-addition of the three molecules of Ipp onto DMAPP to form geranylgeranyl pyrophosphate which is a precursor of the ether-linked lipids. catalyzes the consecutive condensation of homoallylic diphosphate of isopentenyl diphosphates (Ipp, C5) with allylic diphosphates to synthesize prenyl diphosphates of various chain lengths.
4553927	terpene cyclase; stop codon; function unknown but possibly involved in catalysis of cyclisation cascades involving polyisoprene substrates.
4553929	transposase for IS2606; frame shift mutation; required for the transposition of the insertion element IS2606.
4553941	conserved hypothetical secreted protein; Frame shift
4553944	conserved hypothetical protein; Disrupted by IS2404 insertion; function unknown; contains a ribonuclease H-like motif
4554544	N-term transposase for IS2404; Site of possible DNA deletion, resulting in the apparent divergent transcription of the overlapping orfs in this region; required for the transposition of insertion element IS2404.
4553406	adenylate cyclase; frameshift mutation
4553412	transposase for IS2606; stop codon; required for the transposition of the insertion element IS2606.
4553415	phage-related integrase; frame shift mutation
4553370	C-term hypothetical protein; Putative start codon mutated
4553374	lipoprotein aminopeptidase LpqL_1 - pseudogene  - pseudogene, pseudogene, pseudogene; Frame shift; function unknown, hydrolyzes peptides and/or proteins.
4553378	transposase for IS2606; Frame shift; required for the transposition of the insertion element IS2606.
4553299	conserved hypothetical protein; Frame shift
4553304	two-component hybrid sensor and regulator; frame shift mutation
4553306	metal cation transporting p-type ATPase CtpH; disruption by insertion sequence; metal cation-transporting ATPase; may catalyze the transport of undeterminaed metal cation with hydrolyse of ATP [catalytic activity: ATP + H(2)O + undeterminted metal cation (in) = ADP + phosphate + undeterminaed metal cation (out)]
4553308	transposase for IS2404; stop codon; required for the transposition of insertion element IS2404.
4553309	N-term PPE family protein; Disruption by insertion sequence and/or DNA deletion
4553284	conserved hypothetical membrane protein; frame shift mutation
4553288	conserved hypothetical protein; frame shift mutation; function unknown but contains alpha/beta-hydrolase superfamily domain
4553296	low molecular weight antigen Cfp2; frame shift mutation; function not known (putative secreted protein); may play a role in the development of protective immune responses.
4553165	conserved hypothetical protein; frame shift mutation; function unknown but contains ferritin/ribonucleotide reductase-like superfamily domain
4553118	gamma-glutamyltranspeptidase precursor GgtB; frame shift mutation; plays a key role in the gamma-glutamyl cycle, a pathway for the synthesis and degradation of glutathione [catalytic activity: 5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl-amino acid]
4553119	conserved hypothetical membrane protein; frame shift mutation; function unknown but domain identity suggests a role in transporting oligopeptides as signals across the membrane.
4553091	enhanced intracellular survival protein Eis; frame shift mutation; supposed involved in intracellular survival. possibly associated with the cell surface and secreted.
4553055	conserved hypothetical protein; stop codon
4553062	adenylate and guanylate cyclase; frame shift mutation; generates 3,'5'-cyclic (A/G)mp and diphosphate (or pyrophosphate) from (A/G)tp.
4553001	cytochrome P450 268A2 Cyp268A2P; frame shift mutation; cytochromes P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
4553003	PE-PGRS family protein; frame shift mutation
4549707	C4-dicarboxylate-transport transmembrane protein DctA; stop codon; involved in the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the inner membrane. responsible for the translocation of the substrate across the membrane.
4549708	conserved hypothetical protein; frame shift mutation; function unknown.
4549715	alpha-glucosidase AglA; frame shift mutation
4549716	membrane-associated phospholipase C 2 PlcB_1; frame shift mutation; hydrolyzes sphingomyelin in addition to phosphatidylcholine. probable virulence factor implicated in the pathogenesis of mycobacterium tuberculosis at the level of intracellular survival, by the alteration of cell signaling events or by direct cytotoxicity [catalytic activity: a phosphatidylcholine + H(2)O = 1,2- diacylglycerol + choline phosphate]
4549718	drug-transport integral membrane protein; frame shift mutation, stop codon; thought to be involved in transport of drug across the membrane (export): drug resistance by an export mechanism (conferes resistance to toxic compounds by removing them for the cells) responsible for the translocation of the substrate across the membrane.
4549719	molybdopterin biosynthesis protein MoeY_1; frame shift mutation; involved in biosynthesis of a demolybdo cofactor (molybdopterin), necessary for molybdoenzymes. plays a role in the activation of the small subunit of the molybdopterin converting factor (MoaD)
4549724	NAD-dependent glutamate dehydrogenase Gdh; frame shift mutation; catabolic GlutDH involved in the utilization of glutamate and other amino acids of the glutamate family. generates 2-oxoglutarate from L-glutamate [catalytic activity: L-glutamate + H(2)O + NAD(+) = 2-oxoglutarate + NH(3) + NADH]
4549727	transposase for IS2404; stop codon; required for the transposition of insertion element IS2404.
4549728	membrane-bound C-5 sterol desaturase Erg3_2; frame shift mutation; involved in lipid desaturation
4549729	glycerol-3-phosphate acyltransferase PlsB2; frame shift mutation; involved in phospholipid biosynthesis (at the first step) may also function in the regulation of membrane biogenesis [catalytic activity: acyl-CoA + SN-glycerol 3- phosphate = CoA + 1-acyl-SN-glycerol 3-phosphate]
4549734	cutinase precursor; frame shift mutation; hydrolyzes cutin.
4553470	acetyl-/propionyl-CoA carboxylase (beta subunit) AccD1; frame shift mutation; provides the activated intermediates for fatty acid biosythensis E.G. malonyl CoA from acetyl CoA
4553473	fatty-acid-CoA ligase FadD35; disruption by insertion sequence; function unknown, but involved in lipid degradation.
4553479	conserved hypothetical protein; frame shift mutation
4554338	YrbE family protein YrbE5B; frame shift mutation; function unknown but similar to Ttg2B-like ABC-type transport system involved in resistance to organic solvents, permease component.
4554342	Mce family protein Mce5D, pseudogene.; stop codon; this family of proteins contains the Mce (mycobacterial cell entry) proteins from mycobacterium tuberculosis. the archetype (Rv0169), was isolated as being necessary for colonisation of, and survival within, the macrophage. this family contains proteins of unknown function from other bacteria.
4554251	conserved hypothetical regulatory protein; frame shift mutation
4554257	two component sensor kinase; stop codon; involved in unknown signal transduction mechanism.
4554259	N-term conserved membrane hypothetical protein; frame shift mutation
4554260	C-term conserved hypothetical membrane protein; frame shift mutation
4554265	NAD-dependent aldehyde dehydrogenase; stop codon; thought to oxidize a wide variety of aliphatic and aromatic aldehydes.
4554269	cytochrome P450 269A1 Cyp269A1P; frame shift mutation; cytochromes P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
4554150	conserved hypothetical protein; stop codon; function unknown but contains acyl-CoA transferases/carnitine dehydratase domain homology
4554154	cytochrome P450 138A4 Cyp138A4P; frame shift mutation; cytochromes P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
4554155	transposase for IS2606; frame shift mutation; required for the transposition of the insertion element IS2606.
4554157	drug-transport integral membrane protein; frame shift mutation; thought to be involved in transport of drug across the membrane (export): drug resistance by an export mechanism (conferes resistance to toxic compounds by removing them for the cells) responsible for the translocation of the substrate across the membrane.
4554130	acyl-CoA dehydrogenase; frame shift mutation; function unknown, but involved in lipid degradation.
4554134	PE family protein; stop codon
4554139	PPE family protein; stop codon
4554140	PE-PGRS family protein; stop codon
4554143	acyl-CoA dehydrogenase; disruption by insertion sequence; function unknown, but supposed involvement in lipid degradation.
4554144	transposase for IS2404; required for the transposition of insertion element IS2404.
4553910	acyl-CoA dehydrogenase; stop codon; function unknown, but involved in lipid degradation.
4553784	fatty-acid-CoA ligase; stop codon; function unknown, but involved in lipid degradation.
4553787	conserved hypothetical protein; stop codon; function unknown.
4553797	fatty-acid-CoA ligase FadD35_1; frame shift mutation; function unknown, but involved in lipid degradation.
4553798	fatty-acid-CoA ligase; stop codon; function unknown, but involved in lipid degradation.
4553713	beta-ketoacyl CoA thiolase; frame shift mutation; function unknown, but supposed involved in lipid degradation (BetA oxidation)
4553715	C-term acyl-CoA dehydrogenase FadE25_3; DNA deletion; function unknown, but involved in lipid degradation [catalytic activity: acyl-CoA + ETF = 2,3-dehydroacyl-CoA + reduced ETF]
4553716	conserved hypothetical protein; stop codon; function unknown but contains a protein-kinase superfamily domain
4553595	integral membrane protein; stop codon
4552509	adenylate cyclase; N-term disrupted by IS2606 insertion. C-term disrupted by IS2404 insertion.; thought to play a role in regulation of cellular metabolism by catalysing the synthesis of a second messenger, camp [catalytic activity: ATP = 3',5'-cyclic AMP + pyrophosphate]
4550728	conserved hypothetical membrane protein; frame shift mutation
4550729	conserved hypothetical transport protein; DNA deletion; function unknown but contains TrkA domain. this domain is found in a wide variety of proteins. these protein include potassium channels P31069, phosphoesterases Q59027, and various other transporters. this domain binds to NAD.
4550743	conserved hypothetical protein; frame shift mutation; function unknown but contains alpha/beta-hydrolase superfamily domain
4549959	PE-PGRS family protein; frame shift mutation
4549966	transmembrane serine/threonine-protein kinase H PknH; frame shift mutation; involved in signal transduction (via phosphorylation) thought to be involved in arabinan metabolism, phosphorylating perhaps EmbR [catalytic activity: ATP + a protein = ADP + a phosphoprotein]
4550087	conserved hypothetical protein; stop codon
4550088	peroxidase BpoA; stop codon; supposed involved in detoxification reactions.
4550092	onserved hypothetical membrane protein; frame shift mutation
4550100	enoyl-CoA hydratase EchA13_1; frame shift mutation; oxidizes fatty acids using specific components (by similarity) [catalytic activity: (3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H(2)O]
4550103	C-term conserved transmembrane transport protein; DNA deletion; function unknown. belongs to the predicted drug exporters of the Rnd superfamily
4550107	conserved hypothetical secreted protein; frame shift mutation
4552611	N-term PE-PGRS family protein; DNA deletion
4552614	amidohydrolase 2-like conserved hypothetical protein; stop codon; function unknown. these proteins are related to the metal-dependent hydrolase superfamily.
4551361	conserved hypothetical membrane protein; N-term truncated, missing 70 aa wrt orthologues. Frame shift mutation.
4551362	PE-PGRS family protein, potential pseudogene; frame shift mutation; function unknown. seems to influence both cell surface interactions among mycobacteria and the interactions of bacteria with macrophages.
4552420	N-term conserved hypothetical protein; DNA deletion
4552424	PE-PGRS family protein; frame shift mutation
4552430	PE-PGRS family protein; frame shift mutation
4552285	C-term PPE family protein; disruption by insertion sequence
4552287	C-term PPE family protein; disruption by insertion sequence
4552298	conserved hypothetical membrane protein; frame shift mutation
4551585	DNA repair protein RadA; frame shift mutation; involved in genetic recombination. may play a role in the repair of endogenous alkylation damage.
4551591	N-term conserved hypothetical protein, TB11.2; stop codon
4551595	multifunctional geranylgeranyl pyrophosphate synthetase IdsA1; stop codon; involved in the biosynthesis of membrane ether- linked lipids. catalyzes the trans-addition of the three molecules of Ipp onto DMAPP to form geranylgeranyl pyrophosphate which is a precursor of the ether-linked lipids [catalytic activity1: dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate] [catalytic activity2: geranyl diphosphate + isopentenyl diphosphate = diphosphate + trans,trans- farnesyl diphosphate] [catalytic activity3: trans-trans- farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate]
4551599	C-term PE-PGRS family protein; disruption by insertion sequence
4549742	C-term PE-PGRS family protein; disruption by insertion sequence
4551223	PE-PGRS family protein; frame shift mutation
4551226	N-term cell filamentation protein Fic; disruption by insertion sequence; could be involved in cell filamentation induced by cyclic AMP and may have some role in cell division.
4551236	DEAD/DEAH box helicase; frame shift mutation; function unknown. helicases are involved in unwinding nucleic acids. the DeaD box helicases are involved in various aspects of RNA metabolism
4551146	conserved hypothetical membrane protein; frame shift mutation
4551165	conserved hypothetical protein; frame shift mutation
4551253	cytochrome P450 137A2 Cyp137A2P; frame shift mutation; cytochromes P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
4551110	conserved hypothetical response regulatory protein; frame shift mutation; function unknown: contains AmiR and NasR transcription antitermination regulatory domain. these are RNA-binding domains found in the response regulators of two-component systems
4551111	C-term conserved hypothetical protein; N-term missing 35 aa
4551112	formate dehydrogenase, alpha subunit, selenocysteine-containing; frame shift mutation; function unknown, potential role in anaerobic electron transport chain. contains formate dehydrogenase/DMSO reductase superfamily domain
4551113	formate dehydrogenase, beta subunit, selenocysteine- containing; frame shift mutation; function unknown, potential role in anaerobic electron transport chain. contains formate dehydrogenase/DMSO reductase superfamily domain
4551114	Fe-S-cluster-containing hydrogenase, HybA; stop codon
4551092	conserved hypothetical protein; frame shift mutation
4551093	conserved hypothetical protein; stop codon; function unknown, contains thiopurine S- methyltransferase domain. this is a cytosolic enzyme that catalyses S-methylation of aromatic and heterocyclic sulfhydryl compounds
4551098	glutamate--cysteine ligase GshA; frame shift mutation; involved in glutathione biosynthesis (at the first step) [catalytic activity: ATP + L-glutamate + L-cysteine = ADP + orthophosphate + gamma-L-glutamyl-L-cysteine]
4551103	C-term PE-PGRS family protein; DNA deletion
4551107	drugs-transport transmembrane ATP-binding protein ABC transporter; stop codon; thought to be involved in active transport of drugs across the membrane (export): multidrugs resistance by an export mechanism. responsible for energy coupling to the transport system and for the translocation of the substrate across the membrane.
4551314	cyclopropane-fatty-acyl-phospholipid synthase; frame shift mutation; cyclopropane-fatty-acyl-phospholipid synthase or Cfa synthase  catalyses the reaction:  S-adenosyl-L- methionine + phospholipid olefinic fatty acid -> S- adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid. Cfa synthase is closely related to methyltransferases.
4550281	conserved hypothetical protein; frame shift mutation
4550282	conserved hypothetical protein; frame shift mutation
4550283	C-term conserved hypothetical protein; First 50 aa missing
4550286	conserved hypothetical membrane protein; frame shift mutation
4550290	membrane-anchored adenylyl cyclase; frame shift mutation; involved in camp synthesis [catalytic activity: ATP = 3',5'-cyclic AMP + diphosphate] also acts on dATP to form 3',5'-cyclic damp. requires pyruvate. activated by NAD(+) in presence of NAD(P)(+)--arginine ADP- ribosyltransferase.
4550293	adenylyl cyclase; frame shift mutation
4550295	PPE family protein; stop codon
4550502	cytochrome P450 157A4 Cyp157A4P; frame shift mutation; cytochromes P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
4550505	conserved hypothetical protein; frame shift mutation
4550384	osmoprotectant transport ATP-binding protein ABC transporter ProV; frame shift mutation; thought to be involved in active transport of osmoprotectant (glycine betaine/carnitine/choline/L- proline) across the membrane (import) responsible for energy coupling to the transport system.
4550387	acyl-CoA dehydrogenase FadE36; stop codon; function unknown, but possibly involvement in lipid degradation.
4550390	N-term PE-PGRS family protein; DNA deletion
4550398	two component sensor kinase TcrY; frame shift mutation; sensor part of a two component regulatory system.
4550559	transposase for IS2404; frame shift mutation; required for the transposition of insertion element IS2404.
4550561	mid-section conserved hypothetical membrane protein; DNA deletion
4549894	C-term PPE family protein; disruption by insertion sequence
4549896	PPE family protein; disruption by insertion sequence, frame shift mutation
4549898	secreted antigen 85-C FbpC_2; disruption by insertion sequence; proteins of the antigen 85 complex are responsible for the high affinity of mycobacteria to fibronectin. possesses a mycolyltransferase activity required for the biogenesis of trehalose dimycolate (cord factor), a dominant structure necessary for maintaining cell wall integrity.
4550211	PE-PGRS family protein; DNA deletion, frame shift mutation
4550212	N-term PE-PGRS family protein; DNA deletion
4550217	oxidoreductase; frame shift mutation; function unknown, probably involved in cellular metabolism.
4550221	bifunctional enzyme: 2-hydroxyhepta-2,4-diene-1,7- dioate isomerase (HHDD isomerase) + cyclase/dehydrase; frame shift mutation; function unknown, probably involved in cellular metabolism, possibly in a degradation pathway.
4550226	transmembrane serine/threonine-protein kinase D PknD; frame shift mutation; involved in signal transduction (via phosphorylation) thought to regulate phosphate transport. can phosphorylate the peptide substrate myelin basic protein (MBP) at serine and threonine residues. can be autophosphorylated on threonine residues [catalytic activity: ATP + a protein = ADP + a phosphoprotein]
4550231	conserved hypothetical protein; frame shift mutation
4550240	N-term PE-PGRS family protein; DNA deletion
4550200	N-term lipid carrier protein or keto acyl-CoA thiolase; disruption by insertion sequence; thought to be involved in degradative pathways such as fatty acid beta_oxidation.
4550202	conserved transmembrane ATP-binding protein ABC transporter; stop codon - missing C-term 180 aa.; thought to be involved in active transport of undeterminated substrate (possibly lipooligosaccharide) across the membrane. responsible for energy coupling to the transport system and for the translocation of the substrate across the membrane.
4550203	transmembrane serine/threonine-protein kinase; frame shift mutation; involved in signal transduction (via phosphorylation) [catalytic activity: ATP + a protein = ADP + a phosphoprotein]
4550207	N-term conserved hypothetical membrane protein; disruption by insertion sequence
4549794	C-term conserved hypothetical exported protein; disruption by insertion sequence
4549795	conserved hypothetical membrane protein; disruption by insertion sequence
4549803	C-term conserved hypothetical integral membrane protein; DNA deletion - missing N-term 75 aa.; thought to be involved in transport of undeterminated substrate (possibly macrolide) across the membrane (export) responsible for the translocation of the undeterminated substrate across the membrane.
4549805	cytochrome P450 130A4 Cyp130A4P; frame shift mutation; cytochromes P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
4549920	cold-shock DEAD-Box protein a homolog DeaD; frame shift mutation; has a helix-destabilizing activity
4549932	magnesium and cobalt transport transmembrane protein CorA; C-term disrupted by insertion elemnet IS2404.; thought to be involved in transport of magnesium and cobalt ions across the membrane. responsible for the translocation of the substrate across the membrane.
4549902	sugar-transport ATP-binding protein ABC transporter SugC; N-term interupted by internal stop codon.; involved in active transport of sugar across the membrane (import) responsible for energy coupling to the transport system.
4549905	C-term sugar-binding lipoprotein LpqY; N-term truncated by 244aa.; thought to be involved in active transport of sugar across the membrane (import)
4549913	PPE family protein; Frame shift mutation.
4549914	tetronasin-transport integral membrane protein ABC transporter; C-term interupted by internal stop codon.; thought to be involved in active transport of tetronasin across the membrane (export): tetronasin resistance by an export mechanism. responsible for the translocation of the substrate across the membrane.
4549917	PE-PGRS family protein; C-term disrupted by frame shift mutation.
4549919	N-term glycosyl transferase; C-term at MUL_0963; C-term disrupted by IS2404 insertion element (missing 190aa); function unknown, probably involved in cellular metabolism
4549811	transposase for IS2404; frame shift mutation; required for the transposition of insertion element IS2404.
4549813	N-term PPE family protein; C-term truncated by IS2606
4549815	N-term PPE family protein; C-term truncated by insertion element IS2606
4554003	PE-PGRS family protein; frame shift mutation
4551450	conserved hypothetical protein; N-term interupted by internal stop codon.
4553068	C-term transposase for IS2606; disruption by insertion sequence; required for the transposition of the insertion element IS2606.
4553073	N-term conserved hypothetical alanine and glycine rich protein; C-term disrupted by insertion element IS2404
4553078	conserved hypothetical alanine and proline rich protein; Frame shift mutation.
4554530	C-term conserved transmembrane transport protein MmpL2; N-term disrupted by insertion element IS2404 (missing 695aa); function unknown. thought to be involved in fatty acid transport.
4554541	conserved integral membrane transport protein; frame shift mutation; function unknown, belongs to the major facilitator superfamily (MFS)
4554542	monoxygenase; Frame shift mutation; function unknown, probably involved in cellular metabolism
4554543	N-term conserved hypothetical protein; C-term disrupted by IS2404.
4550812	oxidoreductase; C-term disrupted by IS2404 insertion element (missing 50aa); function unknown, probably involved in cellular metabolism.
4554493	PE-PGRS family protein; frame shift mutation
4554501	conserved hypothetical secreted protein; N-term interupted by internal stop codon (missing first 215aa)
4554503	alternative RNA polymerase sigma factor; frame shift mutation; the sigma factor is an initiation factor that promotes attachment of the RNA polymerase to specific initiation sites and then is released.
4554505	C-term membrane protein; N-term truncated by 90aa.
4554372	glycosyl transferase; Frame shift mutation.; function unknown; probably involved in cellular metabolism
4554374	conserved hypothetical membrane protein; Frame shift mutation.; function unknown, possibly involved in cell envelope biogenesis, outer membrane.
4554306	hypothetical protein; frame shift mutation
4554314	oxidoreductase; stop codon; similar to coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin- dependent oxidoreductases but has in-frame stop codon
4554316	PE-PGRS family protein; frame shift mutation
4551294	C-term PPE family protein; disruption by insertion sequence
4551298	C-term transposase; DNA deletion; required for the transposition of the insertion element IS1554.
4551325	acyl-CoA dehydrogenase FadE2; frame shift mutation; function unknown, but involved in lipid degradation.
4551329	conserved hypothetical protein; frame shift mutation
4551331	N-term muconolactone isomerase; disruption by insertion sequence; could be involved in the catabolism of catechol to succinate- and acetyl-CoA in the beta-ketoadipate pathway (at the third step) [catalytic activity: 2,5-dihydro-5- oxofuran-2-acetate = 3,4-dihydro-5-oxofuran-2-acetate]
4551334	peptide synthetase; stop codon
4550904	conserved hypothetical transmembrane protein; frame shift mutation; function unknown, possibly ion channel involved in transport of chloride across the membrane.
4550905	DNA glycosylase; frame shift mutation
4550009	cytochrome P450 138A3 Cyp138A3P; frame shift mutation; cytochromes P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
4550014	conserved hypothetical protein; frame shift mutation
4550022	conserved hypothetical transmembrane protein; stop codon
4552148	conserved hypothetical transmembrane protein; frame shift mutation
4552154	elongation factor G FusA2; frame shift mutation; involved in translation mechanism. this protein may promote the GTP-dependent translocation of the nascent protein chain from the A-site to the P-site of the ribosome.
4550661	dioxygenase; stop codon; function unknown, involved in cellular metabolism.
4550662	short-chain type dehydrogenase/reductase; frame shift mutation; function unknown, probably involved in cellular metabolism.
4550665	fatty-acid-CoA ligase; stop codon; function unknown, but involved in lipid degradation.
4550667	conserved hypothetical protein; stop codon
4550669	PE-PGRS family protein; disruption by insertion sequence
4552025	C-term conserved hypothetical protein; DNA deletion
4552026	membrane-associated phospholipase C 2 PlcB_3; stop codon, frame shift mutation; hydrolyzes sphingomyelin in addition to phosphatidylcholine. probable virulence factor implicated in the pathogenesis of mycobacterium tuberculosis at the level of intracellular survival, by the alteration of cell signaling events or by direct cytotoxicity [catalytic activity: a phosphatidylcholine + H(2)O = 1,2- diacylglycerol + choline phosphate]
4552027	C-term cytochrome P450 274A1 Cyp274A1P; disruption by insertion sequence; cytochromes P450 are a group of heme-thiolate monooxygenases. it oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
4552029	C-term cytochrome P450 226B1 Cyp226B1P; disruption by insertion sequence; cytochromes P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
4549623	conserved transmembrane transport protein MmpL4_6; stop codon; function unknown. thought to be involved in fatty acid transport.
4550837	PE-PGRS family protein; frame shift mutation, DNA deletion
4550840	monoxygenase; stop codon; function unknown, probably involved in cellular metabolism
4550844	conserved hypothetical protein; stop codon
4550848	cation transporter p-type ATPase a CtpA_1; stop codon; cation-transporting ATPase; possibly catalyzes the transport of a cation (possibly copper) with the hydrolyse of ATP [catalytic activity: ATP + H(2)O + cation(in) = ADP + phosphate + cation(out)]
4550852	conserved lipoprotein LpqP_1; frame shift mutation
4554178	conserved hypothetical protein; disruption by insertion sequence
4554181	conserved hypothetical alanine and glycine rich protein; disruption by insertion sequence
4554182	C-term conserved hypothetical alanine and glycine rich protein; DNA deletion
4554188	aminomethyltransferase GcvT_1; frame shift mutation; the glycine cleavage system catalyzes the degradation of glycine [catalytic activity: (6S)- tetrahydrofolate + s-aminomethyldihydrolipoylprotein = (6R)-5,10-methylenetetrahydrofolate + NH3 + dihydrolipoylprotein]
4554189	glycine dehydrogenase GcvB1; frame shift mutation; this family consists of glycine cleavage system P- proteins from bacterial, mammalian and plant sources. the P protein is part of the glycine decarboxylase multienzyme complex also annotated as glycine cleavage system or glycine synthase. the P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor, carbon dioxide is released and the remaining methylamin moiety is then transferred to the lipoamide cofactor of the H protein. GDC consists of four proteins P, H, L and T. the reaction catalysed by this protein is: glycine + lipoylprotein = s-aminomethyldihydrolipoylprotein + CO2
4553750	C-term conserved hypothetical protein; disruption by insertion sequence; function unknown, involved in cellular metabolism.
4553756	N-term PE-PGRS family protein; disruption by insertion sequence
4551487	acyl-CoA dehydrogenase FadE2_1; frame shift mutation; function unknown, but involved in lipid degradation.
4552269	enhanced intracellular survival protein Eis1; frame shift mutation; supposed involved in intracellular survival. possibly associated with the cell surface and secreted.
4551040	conserved hypothetical protein; frame shift mutation, insertion sequence
4551041	hypothetical protein; frame shift mutation
4551042	conserved hypothetical protein; frame shift mutation
4551052	C-term conserved hypothetical protein; disruption by insertion sequence
4552623	acyl-CoA dehydrogenase FadE35; frame shift mutation; function unknown, but involved in lipid degradation.
4552624	PE-PGRS family protein; frame shift mutation
4552400	dehydrogenase; frame shift mutation; function unknown, probably involved in cellular metabolism.
4549662	conserved hypothetical membrane protein; frame shift mutation
4553629	conserved hypothetical transmembrane protein; frame shift mutation
4553630	C-term conserved hypothetical alanine and proline rich membrane protein; DNA deletion; function unknown, appears to be gene created following DNA deletion, creating a translational fusion between two unrelated sequences. C-term 260aa match a CHP alanine-rich CDS predicted in M. marinum.
4553631	conserved hypothetical transmembrane protein; frame shift mutation
4553632	C-term conserved hypothetical alanine rich secreted protein; DNA deletion
4553635	N-term conserved hypothetical membrane protein; disruption by insertion sequence
4553638	conserved hypothetical protein; frame shift mutation
4553639	conserved hypothetical secreted protein; frame shift mutation
4553134	N-term ADP-ribosyltransferase; DNA deletion
4553140	N-term conserved hypothetical protein; DNA deletion