-- dump date   	20140619_155358
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
362242000001	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
362242000002	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
362242000003	P-loop; other site
362242000004	Magnesium ion binding site [ion binding]; other site
362242000005	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
362242000006	Magnesium ion binding site [ion binding]; other site
362242000007	Pfam match to entry PF00991 ParA, ParA family ATPase, E value = 0.00082
362242000008	NusA-like KH domain; Region: KH_5; pfam13184
362242000009	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
362242000010	G-X-X-G motif; other site
362242000011	Prosite match to entry PS50084 KH_TYPE_1 Type-1 KH domain
362242000012	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
362242000013	Catalytic domain of Protein Kinases; Region: PKc; cd00180
362242000014	active site
362242000015	ATP binding site [chemical binding]; other site
362242000016	substrate binding site [chemical binding]; other site
362242000017	activation loop (A-loop); other site
362242000018	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
362242000019	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
362242000020	intersubunit interface [polypeptide binding]; other site
362242000021	Prosite match to entry PS50011 Protein kinase domain, E-value= 8.3e-49
362242000022	Prosite match to entry PS00108, Serine/Threonine protein kinases active-site signature pattern
362242000023	DivIVA domain; Region: DivI1A_domain; TIGR03544
362242000024	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
362242000025	Prosite match to entry PS00152 ATPASE_ALPHA_BETA ATP synthase alpha and beta subunits signature
362242000026	Prosite match to entry PS50099 PRO_RICH Proline-rich region
362242000027	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
362242000028	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
362242000029	phosphopeptide binding site; other site
362242000030	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
362242000031	non-specific DNA binding site [nucleotide binding]; other site
362242000032	salt bridge; other site
362242000033	sequence-specific DNA binding site [nucleotide binding]; other site
362242000034	Prosite match to entry PS50310 ALA_RICH Alanine-rich region.
362242000035	Pfam match to entry PF01381, HTH_3 Helix-turn-helix, E value = 2e-05.
362242000036	Prosite match to entry PS50006 FHA_DOMAIN Forkhead-associated (FHA) domain, Pfam PF00498, FHA, E value = 4.7e-16
362242000037	PknH-like extracellular domain; Region: PknH_C; pfam14032
362242000038	Prosite match to entry PS50099 PRO_RICH Proline-rich region
362242000039	Transcription factor WhiB; Region: Whib; pfam02467
362242000040	Pfam match to entry PF02467 Transcription factor WhiB, E value = 0.00057
362242000041	Transposase, Mutator family; Region: Transposase_mut; pfam00872
362242000042	MULE transposase domain; Region: MULE; pfam10551
362242000043	RES domain; Region: RES; pfam08808
362242000044	Helix-turn-helix domain; Region: HTH_17; pfam12728
362242000045	Transposase [DNA replication, recombination, and repair]; Region: COG5421
362242000046	Transposase [DNA replication, recombination, and repair]; Region: COG5421
362242000047	Transposase, Mutator family; Region: Transposase_mut; pfam00872
362242000048	MULE transposase domain; Region: MULE; pfam10551
362242000049	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
362242000050	Pfam match to entry PF02371, Transposase IS116/IS110/IS902 family, E value = 4.7e-18
362242000051	Transposase [DNA replication, recombination, and repair]; Region: COG5421
362242000052	Transposase [DNA replication, recombination, and repair]; Region: COG5421
362242000053	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242000054	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242000055	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242000056	Transposase, Mutator family; Region: Transposase_mut; pfam00872
362242000057	MULE transposase domain; Region: MULE; pfam10551
362242000058	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
362242000059	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
362242000060	active site
362242000061	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
362242000062	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
362242000063	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956
362242000064	putative NADP binding site [chemical binding]; other site
362242000065	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
362242000066	active site
362242000067	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
362242000068	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
362242000069	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
362242000070	active site
362242000071	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
362242000072	ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952
362242000073	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
362242000074	NADP binding site [chemical binding]; other site
362242000075	active site
362242000076	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
362242000077	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
362242000078	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
362242000079	active site
362242000080	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
362242000081	ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952
362242000082	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
362242000083	NADP binding site [chemical binding]; other site
362242000084	active site
362242000085	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
362242000086	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
362242000087	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
362242000088	active site
362242000089	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
362242000090	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
362242000091	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956
362242000092	putative NADP binding site [chemical binding]; other site
362242000093	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
362242000094	active site
362242000095	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
362242000096	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
362242000097	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
362242000098	active site
362242000099	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
362242000100	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
362242000101	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956
362242000102	putative NADP binding site [chemical binding]; other site
362242000103	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
362242000104	active site
362242000105	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
362242000106	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
362242000107	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
362242000108	active site
362242000109	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
362242000110	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
362242000111	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956
362242000112	putative NADP binding site [chemical binding]; other site
362242000113	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
362242000114	active site
362242000115	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
362242000116	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
362242000117	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
362242000118	active site
362242000119	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
362242000120	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
362242000121	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956
362242000122	putative NADP binding site [chemical binding]; other site
362242000123	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
362242000124	active site
362242000125	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
362242000126	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
362242000127	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
362242000128	active site
362242000129	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
362242000130	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
362242000131	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956
362242000132	putative NADP binding site [chemical binding]; other site
362242000133	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
362242000134	active site
362242000135	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
362242000136	Thioesterase; Region: PKS_TE; smart00824
362242000137	Pfam match to entry PF00550 pp-binding: Phosphopantetheine attachment site - domain 8 of 8, E value = 4.2e-18
362242000138	Pfam match to entry PF00698 Acyl_transf: Acyl transferase domain - domain 8 of 8, E value = 2.6e-88.
362242000139	Pfam match to entry PF02801 ketoacyl-synt_C: Beta-ketoacyl synthase, C-terminal domain - domain 8 of 8, E value = 3e-95
362242000140	Pfam match to entry PF00109 ketoacyl-synt: Beta-ketoacyl synthase, N-terminal domain - domain 8 of 8, E value = 6.8e-138
362242000141	Pfam match to entry PF00550 pp-binding: Phosphopantetheine attachment site - domain 7 of 8, E value = 1.7e-18
362242000142	Pfam match to entry PF00698 Acyl_transf: Acyl transferase domain - domain 7 of 8, E value = 1e-133
362242000143	Pfam match to entry PF02801 ketoacyl-synt_C: Beta-ketoacyl synthase, C-terminal domain - domain 7 of 8, E value = 3e-95
362242000144	Pfam match to entry PF00109 ketoacyl-synt: Beta-ketoacyl synthase, N-terminal domain - domain 7 of 8, E value = 6.8e-138.
362242000145	Pfam match to entry PF00550 pp-binding: Phosphopantetheine attachment site - domain 6 of 8, E value = 1.7e-18
362242000146	Pfam match to entry PF00698 Acyl_transf: Acyl transferase domain - domain 6 of 8, E value = 1e-133
362242000147	Pfam match to entry PF02801 ketoacyl-synt_C: Beta-ketoacyl synthase, C-terminal domain - domain 6 of 8, E value = 3e-95
362242000148	Pfam match to entry PF00109 ketoacyl-synt: Beta-ketoacyl synthase, N-terminal domain - domain 6 of 8, E value = 6.8e-138
362242000149	Pfam match to entry PF00550 pp-binding: Phosphopantetheine attachment site - domain 5 of 8, E value = 1.7e-18
362242000150	Pfam match to entry PF00698 Acyl_transf: Acyl transferase domain - domain 5 of 8, E value = 2.6e-88
362242000151	Pfam match to entry PF02801 ketoacyl-synt_C: Beta-ketoacyl synthase, C-terminal domain - domain 5 of 8, E value = 3e-95
362242000152	Pfam match to entry PF00109 ketoacyl-synt: Beta-ketoacyl synthase, N-terminal domain - domain 5 of 8, E value = 4.1e-138
362242000153	Pfam match to entry PF00550 pp-binding: phosphopantetheine attachment site - domain 4 of 8, E value = 1.7e-18.
362242000154	Pfam match to entry PF00698 Acyl_transf: Acyl transferase domain - domain 4 of 8, E value = 1e-133
362242000155	Pfam match to entry PF02801 ketoacyl-synt_C: Beta-ketoacyl synthase, C-terminal domain - domain 4 of 8, E value = 3e-95
362242000156	Pfam match to entry PF00109 ketoacyl-synt: Beta-ketoacyl synthase, N-terminal domain - domain 4 of 8, E value = 4.9e-138
362242000157	Pfam match to entry PF00550 pp-binding: Phosphopantetheine attachment site - domain 3 of 8, E value = 1.8e-15
362242000158	Pfam match to entry PF00698 Acyl_transf: Acyl transferase domain - domain 3 of 8, E value = 6.1e-83
362242000159	Pfam match to entry PF02801 ketoacyl-synt_C: Beta-ketoacyl synthase, C-terminal domain - domain 3 of 8, E value = 3e-95
362242000160	Pfam match to entry PF00109 ketoacyl-synt: Beta-ketoacyl synthase, N-terminal domain - domain 3 of 8, E value = 4.2e-139
362242000161	Pfam match to entry PF00550 pp-binding: Phosphopantetheine attachment site - domain 2 of 8, E value = 1.8e-15
362242000162	Pfam match to entry PF00698 Acyl_transf: Acyl transferase domain - domain 2 of 8, E value = 6.1e-83
362242000163	Pfam match to entry PF02801 ketoacyl-synt_C: Beta-ketoacyl synthase, C-terminal domain - domain 2 of 8, E value = 3e-95
362242000164	Pfam match to entry PF00109 ketoacyl-synt: Beta-ketoacyl synthase, N-terminal domain - domain 2 of 8, E value = 4.2e-139
362242000165	Pfam match to entry PF00550 pp-binding: Phosphopantetheine attachment site - domain 1 of 8, E value = 7.1e-17
362242000166	Pfam match to entry PF00698 Acyl_transf: Acyl transferase domain - domain 1 of 8, E value = 2.6e-88
362242000167	Pfam match to entry PF02801 ketoacyl-synt_C: Beta-ketoacyl synthase, C-terminal domain - domain 1 of 8, E value = 8.7e-86
362242000168	Pfam match to entry PF00109 ketoacyl-synt: Beta-ketoacyl synthase, N-terminal domain, domain 1 of 8, from aa 26 to 273 E value = 1.7e-98.
362242000169	DDE domain; Region: DDE_Tnp_IS240; pfam13610
362242000170	Integrase core domain; Region: rve; pfam00665
362242000171	Pfam match to entry PF00665 rve Integrase core domain, E value = 0.0068.
362242000172	Transposase; Region: DEDD_Tnp_IS110; pfam01548
362242000173	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
362242000174	Pfam match to entry PF01548 Transposase_9, Transposase, E value = 0.0048.
362242000175	Transposase, Mutator family; Region: Transposase_mut; pfam00872
362242000176	MULE transposase domain; Region: MULE; pfam10551
362242000177	Transposase [DNA replication, recombination, and repair]; Region: COG5421
362242000178	Transposase [DNA replication, recombination, and repair]; Region: COG5421
362242000179	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
362242000180	Erythronolide synthase docking; Region: Docking; pfam08990
362242000181	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
362242000182	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
362242000183	active site
362242000184	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
362242000185	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
362242000186	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
362242000187	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
362242000188	Enoylreductase; Region: PKS_ER; smart00829
362242000189	NAD(P) binding site [chemical binding]; other site
362242000190	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956
362242000191	putative NADP binding site [chemical binding]; other site
362242000192	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
362242000193	active site
362242000194	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
362242000195	Thioesterase; Region: PKS_TE; smart00824
362242000196	Pfam match to entry PF00550 pp-binding: hosphopantetheine attachment site - domain 1 of 1, E value = 4.2e-18.
362242000197	Pfam match to entry PF00698 Acyl_transf: Acyl transferase domain - domain 1 of 1, E value = 2.6e-88.
362242000198	Pfam match to entry PF02801 ketoacyl-synt_C: Beta-ketoacyl synthase, C-terminal domain - domain 1 of 1, E value = 3e-95.
362242000199	Pfam match to entry PF00109 ketoacyl-synt: Beta-ketoacyl synthase, N-terminal domain - domain 1 of 1, E value = 6.5e-139.
362242000200	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
362242000201	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
362242000202	active site
362242000203	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
362242000204	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
362242000205	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956
362242000206	putative NADP binding site [chemical binding]; other site
362242000207	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
362242000208	active site
362242000209	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
362242000210	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
362242000211	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
362242000212	active site
362242000213	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
362242000214	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
362242000215	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956
362242000216	putative NADP binding site [chemical binding]; other site
362242000217	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
362242000218	active site
362242000219	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
362242000220	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
362242000221	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
362242000222	active site
362242000223	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
362242000224	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
362242000225	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
362242000226	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
362242000227	Enoylreductase; Region: PKS_ER; smart00829
362242000228	NAD(P) binding site [chemical binding]; other site
362242000229	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956
362242000230	putative NADP binding site [chemical binding]; other site
362242000231	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
362242000232	active site
362242000233	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
362242000234	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
362242000235	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
362242000236	active site
362242000237	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
362242000238	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
362242000239	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956
362242000240	putative NADP binding site [chemical binding]; other site
362242000241	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
362242000242	active site
362242000243	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
362242000244	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
362242000245	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
362242000246	active site
362242000247	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
362242000248	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
362242000249	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
362242000250	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
362242000251	Enoylreductase; Region: PKS_ER; smart00829
362242000252	NAD(P) binding site [chemical binding]; other site
362242000253	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956
362242000254	putative NADP binding site [chemical binding]; other site
362242000255	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
362242000256	active site
362242000257	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
362242000258	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
362242000259	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
362242000260	active site
362242000261	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
362242000262	ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952
362242000263	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
362242000264	NADP binding site [chemical binding]; other site
362242000265	active site
362242000266	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
362242000267	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
362242000268	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
362242000269	active site
362242000270	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
362242000271	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
362242000272	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956
362242000273	putative NADP binding site [chemical binding]; other site
362242000274	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
362242000275	active site
362242000276	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
362242000277	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
362242000278	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
362242000279	active site
362242000280	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
362242000281	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
362242000282	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
362242000283	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
362242000284	Enoylreductase; Region: PKS_ER; smart00829
362242000285	NAD(P) binding site [chemical binding]; other site
362242000286	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956
362242000287	putative NADP binding site [chemical binding]; other site
362242000288	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
362242000289	active site
362242000290	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
362242000291	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
362242000292	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
362242000293	active site
362242000294	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
362242000295	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
362242000296	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956
362242000297	putative NADP binding site [chemical binding]; other site
362242000298	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
362242000299	active site
362242000300	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
362242000301	Pfam match to entry PF00550 pp-binding: Phosphopantetheine attachment site - domain 9 of 9, E value = 7.6e-19
362242000302	Pfam match to entry PF00698 Acyl_transf: Acyl transferase domain - domain 9 of 9, E value = 2.6e-88
362242000303	Pfam match to entry PF02801 ketoacyl-synt_C: Beta-ketoacyl synthase, C-terminal domain, domain 9 of 9, E value = 3e-95.
362242000304	Pfam match to entry PF00109 ketoacyl-synt: Beta-ketoacyl synthase, N-terminal domain - domain 9 of 9, from aa 15116 to 15363: E value = 3.2e-137
362242000305	Pfam match to entry PF00550 pp-binding: Phosphopantetheine attachment site - domain 8 of 9, E value = 7.6e-19
362242000306	Pfam match to entry PF00698 Acyl_transf: Acyl transferase domain - domain 8 of 9, E value = 1e-133
362242000307	Pfam match to entry PF02801 ketoacyl-synt_C: Beta-ketoacyl synthase, C-terminal domain - domain 8 of 9, E value = 3e-95
362242000308	Pfam match to entry PF00109 ketoacyl-synt: Beta-ketoacyl synthase, N-terminal domain - domain 8 of 9, E value = 4.1e-138
362242000309	Pfam match to entry PF00550 pp-binding: Phosphopantetheine attachment site - domain 7 of 9, E value = 1.7e-18
362242000310	Pfam match to entry PF00698 Acyl_transf: Acyl transferase domain - domain 7 of 9, E value = 1e-133
362242000311	Pfam match to entry PF02801 ketoacyl-synt_C: Beta-ketoacyl synthase, C-terminal domain - domain 7 of 9, E value = 3e-95
362242000312	Pfam match to entry PF00109 ketoacyl-synt: Beta-ketoacyl synthase, N-terminal domain - domain 7 of 9, E value = 5.7e-138.
362242000313	Pfam match to entry PF00550 pp-binding: Phosphopantetheine attachment site - domain 6 of 9, E value = 1.8e-15.
362242000314	Pfam match to entry PF00698 Acyl_transf: Acyl transferase domain - domain 6 of 9, E value = 6.1e-83
362242000315	Pfam match to entry PF02801 ketoacyl-synt_C: Beta-ketoacyl synthase, C-terminal domain - domain 6 of 9, E value = 5.5e-95.
362242000316	Pfam match to entry PF00109 ketoacyl-synt: Beta-ketoacyl synthase, N-terminal domain - domain 6 of 9, E value = 1.7e-138
362242000317	Pfam match to entry PF00550 pp-binding: Phosphopantetheine attachment site - domain 5 of 9, E value = 7.1e-17.
362242000318	Pfam match to entry PF00698 Acyl_transf: Acyl transferase domain - domain 5 of 9, E value = 1e-133
362242000319	Pfam match to entry PF02801 ketoacyl-synt_C: Beta-ketoacyl synthase, C-terminal domain - domain 5 of 9, E value = 5.5e-95.
362242000320	Pfam match to entry PF00109 ketoacyl-synt: Beta-ketoacyl synthase, N-terminal domain - domain 5 of 9, E value = 1.6e-137
362242000321	Pfam match to entry PF00550 pp-binding: Phosphopantetheine attachment site - domain 4 of 9, E value = 7.6e-19
362242000322	Pfam match to entry PF00698 Acyl_transf: Acyl transferase domain - domain 4 of 9, E value = 1e-133
362242000323	Pfam match to entry PF02801 ketoacyl-synt_C: Beta-ketoacyl synthase, C-terminal domain - domain 4 of 9, E value = 3e-95.
362242000324	Pfam match to entry PF00109 ketoacyl-synt: Beta-ketoacyl synthase, N-terminal domain - domain 4 of 9, E value = 6.1e-138.
362242000325	Pfam match to entry PF00550 pp-binding: Phosphopantetheine attachment site - domain 3 of 9, E value = 7.1e-17.
362242000326	Pfam match to entry PF00698 Acyl_transf: Acyl transferase domain - domain 3 of 9, E value = 1e-133
362242000327	Pfam match to entry PF02801 ketoacyl-synt_C: Beta-ketoacyl synthase, C-terminal domain - domain 3 of 9, E value = 5.5e-95
362242000328	Pfam match to entry PF00109 ketoacyl-synt: Beta-ketoacyl synthase, N-terminal domain - domain 3 of 9, E value = 4.4e-139
362242000329	Pfam match to entry PF00550 pp-binding: Phosphopantetheine attachment site - domain 2 of 9, E value = 7.1e-17.
362242000330	Pfam match to entry PF00698 Acyl_transf: Acyl transferase domain - domain 2 of 9, E value = 2.6e-88
362242000331	Pfam match to entry PF02801 ketoacyl-synt_C: Beta-ketoacyl synthase, C-terminal domain - domain 2 of 9, E value = 5.5e-95.
362242000332	Pfam match to entry PF00109 ketoacyl-synt: Beta-ketoacyl synthase, N-terminal domain - domain 2 of 9, E value = 1.7e-138.
362242000333	Pfam match to entry PF00550 pp-binding: Phosphopantetheine attachment site - domain 1 of 9, E value = 7.1e-17.
362242000334	Pfam match to entry PF00698 Acyl_transf: Acyl transferase domain - domain 1 of 9, E value = 2.6e-88
362242000335	Pfam match to entry PF02801 ketoacyl-synt_C: Beta-ketoacyl synthase, C-terminal domain - domain 1 of 8, E value = 8.7e-86
362242000336	Pfam match to entry PF00109 ketoacyl-synt: Beta-ketoacyl synthase, N-terminal domain - domain 1 of 9, E value = 1.7e-98
362242000337	DDE domain; Region: DDE_Tnp_IS240; pfam13610
362242000338	Integrase core domain; Region: rve; pfam00665
362242000339	Pfam match to entry PF00665 rve Integrase core domain, E value = 0.0068.
362242000340	Transposase; Region: DEDD_Tnp_IS110; pfam01548
362242000341	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
362242000342	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
362242000343	Pfam match to entry PF02371, Transposase_20, Transposase IS116/IS110/IS902 family, E value = 6.9e-11.
362242000344	"initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827
362242000345	3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332
362242000346	dimer interface [polypeptide binding]; other site
362242000347	active site
362242000348	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242000349	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242000350	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242000351	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
362242000352	Transposase; Region: HTH_Tnp_1; pfam01527
362242000353	Pfam match to entry PF01527 Transposase_8, Transposase, E value = 5.4e-22. This family consists of various E. coli insertion elements and other bacterial transposases some of which are members of the IS3 family.
362242000354	Transposase, Mutator family; Region: Transposase_mut; pfam00872
362242000355	MULE transposase domain; Region: MULE; pfam10551
362242000356	Transposase; Region: HTH_Tnp_1; pfam01527
362242000357	Pfam match to entry PF01527, Transposase_8, Transposase, E value = 2.4e-20. This family consists of various E. coli insertion elements and other bacterial transposases some of which are members of the IS3 family.
362242000358	putative transposase OrfB; Reviewed; Region: PHA02517
362242000359	HTH-like domain; Region: HTH_21; pfam13276
362242000360	Integrase core domain; Region: rve; pfam00665
362242000361	Integrase core domain; Region: rve_3; pfam13683
362242000362	Pfam match to entry PF00665 rve, Integrase core domain, E value = 1.3e-23.
362242000363	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
362242000364	Cytochrome P450; Region: p450; cl12078
362242000365	Pfam match to entry PF00067, Cytochrome P450, E value = 1.2e-20.
362242000366	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
362242000367	Pfam match to entry PF00589 Phage_integrase Phage integrase family, E value = 0.018.
362242000368	Transposase, Mutator family; Region: Transposase_mut; pfam00872
362242000369	MULE transposase domain; Region: MULE; pfam10551
362242000370	Protein of unknown function (DUF2511); Region: DUF2511; pfam10709
362242000371	Protein of unknown function (DUF2511); Region: DUF2511; pfam10709
362242000372	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
362242000373	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
362242000374	active site
362242000375	DNA binding site [nucleotide binding]
362242000376	Int/Topo IB signature motif; other site
362242000377	Pfam match to entry PF00589, Phage_integrase, Phage integrase family, E value = 6e-26
362242000378	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242000379	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242000380	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242000381	Transposase, Mutator family; Region: Transposase_mut; pfam00872
362242000382	Transposase, Mutator family; Region: Transposase_mut; pfam00872
362242000383	MULE transposase domain; Region: MULE; pfam10551
362242000384	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242000385	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242000386	DEAD-like helicases superfamily; Region: DEXDc; smart00487
362242000387	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
362242000388	ATP binding site [chemical binding]; other site
362242000389	putative Mg++ binding site [ion binding]; other site
362242000390	Pfam match to entry PF00270, DEAD/DEAH box helicase, E value = 0.0071.
362242000391	Prosite match to entry PS00029 LEUCINE_ZIPPER Leucine zipper pattern
362242000392	Protein of unknown function (DUF690); Region: DUF690; cl04939
362242000393	Pfam match to entry PF05108, DUF690, Protein of unknown function (DUF690) - this family contains several uncharacterised bacterial membrane proteins, E value = 2.2e-49.
362242000394	Transposase, Mutator family; Region: Transposase_mut; pfam00872
362242000395	MULE transposase domain; Region: MULE; pfam10551
362242000396	Prosite match to entry PS50310 ALA_RICH Alanine-rich region
362242000397	Prosite match to entry PS00015 NUCLEAR Bipartite nuclear targeting sequence
362242000398	Prosite match to entry PS50310 ALA_RICH Alanine-rich region
362242000399	Prosite match to entry PS50310 ALA_RICH Alanine-rich region.
362242000400	Prosite match to entry PS50099 PRO_RICH Proline-rich region
362242000401	Protein of unknown function (DUF2710); Region: DUF2710; pfam10921
362242000402	Prosite match to entry PS00029 LEUCINE_ZIPPER Leucine zipper pattern
362242000403	Protein of unknown function (DUF2580); Region: DUF2580; pfam10824
362242000404	Domain of unknown function (DUF4226); Region: DUF4226; pfam10774
362242000405	Prosite match to entry PS00017 ATP_GTP_A- ATP/GTP-binding site motif A (P-loop)
362242000406	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
362242000407	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
362242000408	Walker A motif; other site
362242000409	ATP binding site [chemical binding]; other site
362242000410	Walker B motif; other site
362242000411	arginine finger; other site
362242000412	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
362242000413	DnaA box-binding interface [nucleotide binding]; other site
362242000414	DNA polymerase III subunit beta; Validated; Region: PRK07761
362242000415	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
362242000416	putative DNA binding surface [nucleotide binding]; other site
362242000417	dimer interface [polypeptide binding]; other site
362242000418	beta-clamp/clamp loader binding surface; other site
362242000419	beta-clamp/translesion DNA polymerase binding surface; other site
362242000420	recF protein; Region: recf; TIGR00611
362242000421	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
362242000422	Walker A/P-loop; other site
362242000423	ATP binding site [chemical binding]; other site
362242000424	Q-loop/lid; other site
362242000425	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
362242000426	ABC transporter signature motif; other site
362242000427	Walker B; other site
362242000428	D-loop; other site
362242000429	H-loop/switch region; other site
362242000430	hypothetical protein; Provisional; Region: PRK03195
362242000431	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
362242000432	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
362242000433	Mg2+ binding site [ion binding]; other site
362242000434	G-X-G motif; other site
362242000435	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
362242000436	anchoring element; other site
362242000437	dimer interface [polypeptide binding]; other site
362242000438	ATP binding site [chemical binding]; other site
362242000439	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
362242000440	active site
362242000441	putative metal-binding site [ion binding]; other site
362242000442	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
362242000443	DNA gyrase subunit A; Validated; Region: PRK05560
362242000444	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
362242000445	CAP-like domain; other site
362242000446	active site
362242000447	primary dimer interface [polypeptide binding]; other site
362242000448	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
362242000449	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
362242000450	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
362242000451	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
362242000452	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
362242000453	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
362242000454	Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089
362242000455	Methyltransferase domain; Region: Methyltransf_23; pfam13489
362242000456	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
362242000457	S-adenosylmethionine binding site [chemical binding]; other site
362242000458	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
362242000459	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
362242000460	DNA binding residues [nucleotide binding]
362242000461	dimer interface [polypeptide binding]; other site
362242000462	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
362242000463	Protein of unknown function (DUF2562); Region: DUF2562; pfam10814
362242000464	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
362242000465	active site
362242000466	Protein of unknown function (DUF2581); Region: DUF2581; pfam10756
362242000467	putative septation inhibitor protein; Reviewed; Region: PRK00159
362242000468	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879
362242000469	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
362242000470	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
362242000471	Glutamine amidotransferase class-I; Region: GATase; pfam00117
362242000472	glutamine binding [chemical binding]; other site
362242000473	catalytic triad [active]
362242000474	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
362242000475	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
362242000476	active site
362242000477	ATP binding site [chemical binding]; other site
362242000478	substrate binding site [chemical binding]; other site
362242000479	activation loop (A-loop); other site
362242000480	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
362242000481	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
362242000482	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
362242000483	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
362242000484	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
362242000485	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
362242000486	Catalytic domain of Protein Kinases; Region: PKc; cd00180
362242000487	active site
362242000488	ATP binding site [chemical binding]; other site
362242000489	substrate binding site [chemical binding]; other site
362242000490	activation loop (A-loop); other site
362242000491	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
362242000492	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
362242000493	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
362242000494	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
362242000495	active site
362242000496	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
362242000497	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
362242000498	phosphopeptide binding site; other site
362242000499	Protein of unknown function (DUF2662); Region: DUF3662; pfam12401
362242000500	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
362242000501	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
362242000502	phosphopeptide binding site; other site
362242000503	Transposase, Mutator family; Region: Transposase_mut; pfam00872
362242000504	MULE transposase domain; Region: MULE; pfam10551
362242000506	Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cd09593
362242000507	ligand binding site [chemical binding]; other site
362242000508	active site
362242000509	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
362242000510	NAD(P) binding site [chemical binding]; other site
362242000511	active site
362242000512	hypothetical protein; Validated; Region: PRK02101
362242000513	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
362242000514	ABC-ATPase subunit interface; other site
362242000515	putative PBP binding loops; other site
362242000516	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
362242000517	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
362242000518	Walker A/P-loop; other site
362242000519	ATP binding site [chemical binding]; other site
362242000520	Q-loop/lid; other site
362242000521	ABC transporter signature motif; other site
362242000522	Walker B; other site
362242000523	D-loop; other site
362242000524	H-loop/switch region; other site
362242000525	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
362242000526	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
362242000527	putative PBP binding loops; other site
362242000528	dimer interface [polypeptide binding]; other site
362242000529	ABC-ATPase subunit interface; other site
362242000530	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
362242000531	DNA-binding site [nucleotide binding]; DNA binding site
362242000532	RNA-binding motif; other site
362242000533	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
362242000534	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
362242000535	active site
362242000536	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
362242000537	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
362242000538	Coenzyme A binding pocket [chemical binding]; other site
362242000539	Pirin; Region: Pirin; pfam02678
362242000540	Pirin-related protein [General function prediction only]; Region: COG1741
362242000541	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
362242000542	Transcription factor WhiB; Region: Whib; pfam02467
362242000543	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
362242000544	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
362242000545	non-specific DNA binding site [nucleotide binding]; other site
362242000546	salt bridge; other site
362242000547	sequence-specific DNA binding site [nucleotide binding]; other site
362242000548	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
362242000549	NlpC/P60 family; Region: NLPC_P60; pfam00877
362242000550	Domain of unknown function (DUF4226); Region: DUF4226; pfam10774
362242000551	Domain of unknown function (DUF4226); Region: DUF4226; pfam10774
362242000552	Protein of unknown function (DUF2580); Region: DUF2580; pfam10824
362242000553	Protein of unknown function (DUF2694); Region: DUF2694; pfam10904
362242000554	Protein of unknown function (DUF2710); Region: DUF2710; pfam10921
362242000555	TIGR03084 family protein; Region: TIGR03084
362242000556	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
362242000557	Wyosine base formation; Region: Wyosine_form; pfam08608
362242000558	hypothetical protein; Validated; Region: PRK00228
362242000559	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
362242000560	SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593
362242000561	Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738
362242000562	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
362242000563	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
362242000564	active site
362242000565	HIGH motif; other site
362242000566	nucleotide binding site [chemical binding]; other site
362242000567	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
362242000568	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
362242000569	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
362242000570	active site
362242000571	KMSKS motif; other site
362242000572	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
362242000573	tRNA binding surface [nucleotide binding]; other site
362242000574	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
362242000575	short chain dehydrogenase; Provisional; Region: PRK08219
362242000576	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
362242000577	NAD(P) binding site [chemical binding]; other site
362242000578	active site
362242000579	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
362242000580	MarR family; Region: MarR; pfam01047
362242000581	Transcriptional regulators [Transcription]; Region: GntR; COG1802
362242000582	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
362242000583	DNA-binding site [nucleotide binding]; DNA binding site
362242000584	FCD domain; Region: FCD; cl11656
362242000585	probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856
362242000586	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
362242000587	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
362242000588	Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260
362242000589	Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554
362242000590	Predicted transcriptional regulators [Transcription]; Region: COG1695
362242000591	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
362242000592	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
362242000593	Transglycosylase; Region: Transgly; pfam00912
362242000594	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
362242000595	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
362242000596	Predicted integral membrane protein [Function unknown]; Region: COG5650
362242000597	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
362242000598	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
362242000599	conserved cys residue [active]
362242000600	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
362242000601	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
362242000602	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
362242000603	dimer interface [polypeptide binding]; other site
362242000604	ssDNA binding site [nucleotide binding]; other site
362242000605	tetramer (dimer of dimers) interface [polypeptide binding]; other site
362242000606	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
362242000607	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
362242000608	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
362242000609	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
362242000610	replicative DNA helicase; Region: DnaB; TIGR00665
362242000611	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
362242000612	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
362242000613	Walker A motif; other site
362242000614	ATP binding site [chemical binding]; other site
362242000615	Walker B motif; other site
362242000616	DNA binding loops [nucleotide binding]
362242000618	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
362242000619	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
362242000620	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
362242000621	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
362242000622	active site
362242000625	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
362242000626	dimerization interface [polypeptide binding]; other site
362242000627	putative DNA binding site [nucleotide binding]; other site
362242000628	putative Zn2+ binding site [ion binding]; other site
362242000629	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
362242000630	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
362242000633	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
362242000634	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
362242000635	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
362242000636	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
362242000637	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
362242000638	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
362242000639	active site
362242000640	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
362242000641	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
362242000642	Walker A/P-loop; other site
362242000643	ATP binding site [chemical binding]; other site
362242000644	Q-loop/lid; other site
362242000645	ABC transporter signature motif; other site
362242000646	Walker B; other site
362242000647	D-loop; other site
362242000648	H-loop/switch region; other site
362242000649	Protein of unknown function (DUF2587); Region: DUF2587; pfam10759
362242000650	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
362242000651	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
362242000652	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
362242000653	catalytic residue [active]
362242000654	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
362242000655	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
362242000656	NAD(P) binding site [chemical binding]; other site
362242000657	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
362242000658	PPE family; Region: PPE; pfam00823
362242000659	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
362242000660	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242000661	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242000662	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242000664	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242000665	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242000666	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242000667	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
362242000668	Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181
362242000669	active site
362242000670	intersubunit interface [polypeptide binding]; other site
362242000671	zinc binding site [ion binding]; other site
362242000672	Na+ binding site [ion binding]; other site
362242000673	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
362242000674	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
362242000675	Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996
362242000676	ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465
362242000677	Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552
362242000678	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
362242000679	metal ion-dependent adhesion site (MIDAS); other site
362242000680	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823
362242000681	putative hydrophobic ligand binding site [chemical binding]; other site
362242000682	MoxR-like ATPases [General function prediction only]; Region: COG0714
362242000683	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
362242000684	Ligand binding site; other site
362242000685	metal-binding site
362242000686	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
362242000687	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
362242000688	XdhC Rossmann domain; Region: XdhC_C; pfam13478
362242000689	carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416
362242000690	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315
362242000691	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
362242000692	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
362242000693	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
362242000694	catalytic loop [active]
362242000695	iron binding site [ion binding]; other site
362242000696	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
362242000697	Transcriptional regulator [Transcription]; Region: LysR; COG0583
362242000698	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
362242000699	LysR substrate binding domain; Region: LysR_substrate; pfam03466
362242000700	dimerization interface [polypeptide binding]; other site
362242000701	Uncharacterized conserved protein [Function unknown]; Region: COG3360
362242000702	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
362242000703	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
362242000704	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
362242000705	active site
362242000706	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
362242000707	classical (c) SDRs; Region: SDR_c; cd05233
362242000708	NAD(P) binding site [chemical binding]; other site
362242000709	active site
362242000710	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
362242000711	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
362242000712	substrate binding site [chemical binding]; other site
362242000713	oxyanion hole (OAH) forming residues; other site
362242000714	trimer interface [polypeptide binding]; other site
362242000715	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
362242000716	Clp amino terminal domain; Region: Clp_N; pfam02861
362242000717	Clp amino terminal domain; Region: Clp_N; pfam02861
362242000718	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
362242000719	Walker A motif; other site
362242000720	ATP binding site [chemical binding]; other site
362242000721	Walker B motif; other site
362242000722	arginine finger; other site
362242000723	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
362242000724	Walker A motif; other site
362242000725	ATP binding site [chemical binding]; other site
362242000726	Walker B motif; other site
362242000727	arginine finger; other site
362242000728	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
362242000729	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
362242000730	heme-binding site [chemical binding]; other site
362242000731	2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543
362242000732	The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187
362242000733	FAD binding pocket [chemical binding]; other site
362242000734	FAD binding motif [chemical binding]; other site
362242000735	phosphate binding motif [ion binding]; other site
362242000736	beta-alpha-beta structure motif; other site
362242000737	NAD binding pocket [chemical binding]; other site
362242000738	aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081
362242000739	active site
362242000740	catalytic residues [active]
362242000741	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242000742	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242000743	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242000744	Transposase, Mutator family; Region: Transposase_mut; pfam00872
362242000745	MULE transposase domain; Region: MULE; pfam10551
362242000746	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242000747	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242000748	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242000749	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
362242000750	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
362242000751	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
362242000752	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
362242000753	short chain dehydrogenase; Provisional; Region: PRK12829
362242000754	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
362242000755	NAD(P) binding site [chemical binding]; other site
362242000756	active site
362242000757	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
362242000758	NADH(P)-binding; Region: NAD_binding_10; pfam13460
362242000759	NAD(P) binding site [chemical binding]; other site
362242000760	putative active site [active]
362242000761	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
362242000762	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
362242000763	THF binding site; other site
362242000764	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
362242000765	substrate binding site [chemical binding]; other site
362242000766	THF binding site; other site
362242000767	zinc-binding site [ion binding]; other site
362242000768	Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077
362242000769	Predicted membrane protein [Function unknown]; Region: COG2259
362242000770	pyruvate phosphate dikinase; Provisional; Region: PRK05878
362242000771	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
362242000772	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
362242000773	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
362242000774	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
362242000775	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
362242000776	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
362242000777	dimer interface [polypeptide binding]; other site
362242000778	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
362242000779	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
362242000780	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
362242000781	Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023
362242000782	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
362242000783	glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853
362242000784	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
362242000785	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
362242000786	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
362242000787	cyclase homology domain; Region: CHD; cd07302
362242000788	nucleotidyl binding site; other site
362242000789	metal binding site [ion binding]; metal-binding site
362242000790	dimer interface [polypeptide binding]; other site
362242000791	Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998
362242000792	Uncharacterized conserved protein [Function unknown]; Region: COG1359
362242000793	OsmC-like protein; Region: OsmC; pfam02566
362242000794	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
362242000795	Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055
362242000796	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
362242000797	active site
362242000798	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
362242000799	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
362242000800	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
362242000801	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
362242000802	hydrophobic ligand binding site; other site
362242000803	MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013
362242000804	Transposase, Mutator family; Region: Transposase_mut; pfam00872
362242000805	MULE transposase domain; Region: MULE; pfam10551
362242000806	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242000807	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242000808	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242000809	GTP-binding protein YchF; Reviewed; Region: PRK09601
362242000810	YchF GTPase; Region: YchF; cd01900
362242000811	G1 box; other site
362242000812	GTP/Mg2+ binding site [chemical binding]; other site
362242000813	Switch I region; other site
362242000814	G2 box; other site
362242000815	Switch II region; other site
362242000816	G3 box; other site
362242000817	G4 box; other site
362242000818	G5 box; other site
362242000819	Protein of unknown function (DUF933); Region: YchF-GTPase_C; pfam06071
362242000820	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
362242000821	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
362242000822	Exonuclease VII, large subunit [DNA replication, recombination, and repair]; Region: XseA; COG1570
362242000823	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
362242000824	generic binding surface II; other site
362242000825	generic binding surface I; other site
362242000826	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
362242000827	3beta-hydroxysteroid dehydrogenases (3b-HSD)-like, extended (e) SDRs; Region: 3b-HSD-like_SDR_e; cd05241
362242000828	3-beta hydroxysteroid dehydrogenase/isomerase family; Region: 3Beta_HSD; pfam01073
362242000829	putative NAD(P) binding site [chemical binding]; other site
362242000830	active site
362242000831	putative substrate binding site [chemical binding]; other site
362242000832	Rho termination factor, N-terminal domain; Region: Rho_N; cl06505
362242000833	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242000834	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242000835	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242000836	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
362242000837	Domain of unknown function DUF20; Region: UPF0118; pfam01594
362242000838	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
362242000839	Protein of unknown function (DUF4245); Region: DUF4245; pfam14030
362242000840	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
362242000841	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
362242000842	putative active site [active]
362242000843	fumarate hydratase; Reviewed; Region: fumC; PRK00485
362242000844	Class II fumarases; Region: Fumarase_classII; cd01362
362242000845	active site
362242000846	tetramer interface [polypeptide binding]; other site
362242000847	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
362242000848	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
362242000849	NodB motif; other site
362242000850	active site
362242000851	catalytic site [active]
362242000852	metal binding site [ion binding]; metal-binding site
362242000853	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
362242000854	dinuclear metal binding motif [ion binding]; other site
362242000855	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
362242000856	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
362242000857	dimer interface [polypeptide binding]; other site
362242000858	active site
362242000859	glycine-pyridoxal phosphate binding site [chemical binding]; other site
362242000860	folate binding site [chemical binding]; other site
362242000861	pantothenate kinase; Provisional; Region: PRK05439
362242000862	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
362242000863	ATP-binding site [chemical binding]; other site
362242000864	CoA-binding site [chemical binding]; other site
362242000865	Mg2+-binding site [ion binding]; other site
362242000866	PE family; Region: PE; pfam00934
362242000867	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
362242000868	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
362242000869	catalytic residue [active]
362242000870	putative FPP diphosphate  binding site; other site
362242000871	putative FPP binding hydrophobic cleft; other site
362242000872	dimer interface [polypeptide binding]; other site
362242000873	putative IPP diphosphate binding site; other site
362242000874	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
362242000875	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
362242000876	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
362242000877	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
362242000878	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
362242000879	catalytic residues [active]
362242000880	mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446
362242000881	Domain of unknown function (DUF4307); Region: DUF4307; pfam14155
362242000882	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
362242000883	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
362242000884	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
362242000885	cystathionine gamma-synthase; Provisional; Region: PRK07811
362242000886	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
362242000887	homodimer interface [polypeptide binding]; other site
362242000888	substrate-cofactor binding pocket; other site
362242000889	pyridoxal 5'-phosphate binding site [chemical binding]; other site
362242000890	catalytic residue [active]
362242000891	RDD family; Region: RDD; pfam06271
362242000893	cystathionine beta-synthase; Region: cysta_beta; TIGR01137
362242000894	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
362242000895	dimer interface [polypeptide binding]; other site
362242000896	pyridoxal 5'-phosphate binding site [chemical binding]; other site
362242000897	catalytic residue [active]
362242000898	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream.   The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609
362242000899	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
362242000900	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
362242000901	substrate binding pocket [chemical binding]; other site
362242000902	SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836
362242000903	active site
362242000904	oxyanion hole [active]
362242000905	acetyl-CoA acetyltransferase; Provisional; Region: PRK07851
362242000906	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
362242000907	dimer interface [polypeptide binding]; other site
362242000908	active site
362242000909	Predicted membrane protein [Function unknown]; Region: COG4760
362242000910	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
362242000911	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
362242000912	substrate binding site [chemical binding]; other site
362242000913	oxyanion hole (OAH) forming residues; other site
362242000914	trimer interface [polypeptide binding]; other site
362242000915	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
362242000916	enoyl-CoA hydratase; Provisional; Region: PRK05862
362242000917	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
362242000918	substrate binding site [chemical binding]; other site
362242000919	oxyanion hole (OAH) forming residues; other site
362242000920	trimer interface [polypeptide binding]; other site
362242000921	Predicted membrane protein [Function unknown]; Region: COG4425
362242000922	Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081
362242000923	PE family; Region: PE; pfam00934
362242000925	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242000926	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242000927	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242000929	Rhodanese Homology Domain; Region: RHOD; smart00450
362242000930	active site residue [active]
362242000931	Cysteine dioxygenase type I; Region: CDO_I; pfam05995
362242000932	hypothetical protein; Provisional; Region: PRK10279
362242000933	Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228
362242000934	active site
362242000935	nucleophile elbow; other site
362242000936	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
362242000937	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
362242000938	putative active site [active]
362242000939	putative dimer interface [polypeptide binding]; other site
362242000940	Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604
362242000941	hydrophobic ligand binding site; other site
362242000943	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242000944	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242000945	Uncharacterized conserved protein [Function unknown]; Region: COG1262
362242000946	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
362242000947	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
362242000948	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
362242000949	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
362242000950	Sulfatase; Region: Sulfatase; pfam00884
362242000951	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
362242000952	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119
362242000953	dimer interface [polypeptide binding]; other site
362242000954	acyl-activating enzyme (AAE) consensus motif; other site
362242000955	putative active site [active]
362242000956	AMP binding site [chemical binding]; other site
362242000957	putative CoA binding site [chemical binding]; other site
362242000958	Uncharacterized conserved protein [Function unknown]; Region: COG3391
362242000959	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242000960	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242000961	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242000962	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
362242000963	ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494
362242000964	Soluble P-type ATPase [General function prediction only]; Region: COG4087
362242000965	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
362242000966	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
362242000967	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
362242000968	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
362242000969	substrate binding site [chemical binding]; other site
362242000970	oxyanion hole (OAH) forming residues; other site
362242000971	trimer interface [polypeptide binding]; other site
362242000972	Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039
362242000973	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
362242000974	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
362242000975	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
362242000976	putative substrate translocation pore; other site
362242000977	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
362242000978	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
362242000979	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
362242000980	catalytic residue [active]
362242000981	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
362242000982	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
362242000983	dimer interface [polypeptide binding]; other site
362242000984	pyridoxal 5'-phosphate binding site [chemical binding]; other site
362242000985	catalytic residue [active]
362242000986	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
362242000987	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
362242000988	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
362242000989	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
362242000990	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
362242000991	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
362242000992	active site
362242000993	phosphorylation site [posttranslational modification]
362242000994	intermolecular recognition site; other site
362242000995	dimerization interface [polypeptide binding]; other site
362242000996	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
362242000997	DNA binding site [nucleotide binding]
362242000998	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
362242000999	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
362242001000	dimerization interface [polypeptide binding]; other site
362242001001	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
362242001002	dimer interface [polypeptide binding]; other site
362242001003	phosphorylation site [posttranslational modification]
362242001004	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
362242001005	ATP binding site [chemical binding]; other site
362242001006	Mg2+ binding site [ion binding]; other site
362242001007	G-X-G motif; other site
362242001008	BON domain; Region: BON; pfam04972
362242001009	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
362242001010	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
362242001011	ligand binding site [chemical binding]; other site
362242001012	Protein of unknown function (DUF2630); Region: DUF2630; pfam10944
362242001013	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
362242001014	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
362242001015	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
362242001016	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
362242001017	dimer interface [polypeptide binding]; other site
362242001018	active site
362242001019	citrylCoA binding site [chemical binding]; other site
362242001020	NADH binding [chemical binding]; other site
362242001021	cationic pore residues; other site
362242001022	oxalacetate/citrate binding site [chemical binding]; other site
362242001023	coenzyme A binding site [chemical binding]; other site
362242001024	catalytic triad [active]
362242001025	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
362242001026	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
362242001027	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
362242001028	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
362242001029	citrate synthase 2; Provisional; Region: PRK12350
362242001030	Citrate synthase; Region: Citrate_synt; pfam00285
362242001031	oxalacetate binding site [chemical binding]; other site
362242001032	citrylCoA binding site [chemical binding]; other site
362242001033	coenzyme A binding site [chemical binding]; other site
362242001034	catalytic triad [active]
362242001035	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242001036	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242001037	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242001038	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
362242001039	putative dimer interface [polypeptide binding]; other site
362242001040	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
362242001041	Ferredoxin [Energy production and conversion]; Region: COG1146
362242001042	4Fe-4S binding domain; Region: Fer4; pfam00037
362242001043	ferredoxin-NADP+ reductase; Region: PLN02852
362242001044	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
362242001045	P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583
362242001046	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
362242001047	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
362242001048	catalytic residue [active]
362242001049	Protein of unknown function (DUF3071); Region: DUF3071; pfam11268
362242001050	Protein of unknown function (DUF2537); Region: DUF2537; pfam10801
362242001051	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
362242001052	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
362242001053	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
362242001054	MarR family; Region: MarR; pfam01047
362242001055	Protein of unknown function (DUF2530); Region: DUF2530; pfam10745
362242001056	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
362242001057	hydrophobic ligand binding site; other site
362242001058	Protein of unknown function (DUF3027); Region: DUF3027; pfam11228
362242001059	H+ Antiporter protein; Region: 2A0121; TIGR00900
362242001060	Protein of unknown function (DUF2771); Region: DUF2771; pfam10969
362242001061	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
362242001062	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
362242001063	putative dimer interface [polypeptide binding]; other site
362242001064	N-terminal domain interface [polypeptide binding]; other site
362242001065	putative substrate binding pocket (H-site) [chemical binding]; other site
362242001066	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
362242001067	cyclohexanecarboxyl-CoA dehydrogenase; Region: cyc_hxne_CoA_dh; TIGR03207
362242001068	active site
362242001069	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
362242001070	DNA-binding site [nucleotide binding]; DNA binding site
362242001071	RNA-binding motif; other site
362242001072	hypothetical protein; Provisional; Region: PRK11770
362242001073	Domain of unknown function (DUF307); Region: DUF307; pfam03733
362242001074	Domain of unknown function (DUF307); Region: DUF307; pfam03733
362242001075	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
362242001076	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
362242001077	FeS/SAM binding site; other site
362242001078	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
362242001079	Ubiquitin-like proteins; Region: UBQ; cl00155
362242001080	charged pocket; other site
362242001081	hydrophobic patch; other site
362242001082	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
362242001083	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cl00399
362242001084	MoaE homodimer interface [polypeptide binding]; other site
362242001085	MoaD interaction [polypeptide binding]; other site
362242001086	active site residues [active]
362242001087	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
362242001088	MPT binding site; other site
362242001089	trimer interface [polypeptide binding]; other site
362242001090	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
362242001091	trimer interface [polypeptide binding]; other site
362242001092	dimer interface [polypeptide binding]; other site
362242001093	putative active site [active]
362242001094	Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625
362242001095	WYL domain; Region: WYL; pfam13280
362242001096	Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625
362242001097	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
362242001098	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
362242001099	ATP binding site [chemical binding]; other site
362242001100	putative Mg++ binding site [ion binding]; other site
362242001101	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
362242001102	nucleotide binding region [chemical binding]; other site
362242001103	ATP-binding site [chemical binding]; other site
362242001104	probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560
362242001105	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
362242001106	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
362242001107	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
362242001108	hypothetical protein; Validated; Region: PRK05868
362242001109	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
362242001110	hypothetical protein; Provisional; Region: PRK07236
362242001111	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730
362242001112	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
362242001113	substrate binding site [chemical binding]; other site
362242001114	oxyanion hole (OAH) forming residues; other site
362242001115	trimer interface [polypeptide binding]; other site
362242001116	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
362242001117	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
362242001118	acetyl-CoA acetyltransferase; Validated; Region: PRK08242
362242001119	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
362242001120	dimer interface [polypeptide binding]; other site
362242001121	active site
362242001122	aminotransferase; Validated; Region: PRK07777
362242001123	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
362242001124	pyridoxal 5'-phosphate binding site [chemical binding]; other site
362242001125	homodimer interface [polypeptide binding]; other site
362242001126	catalytic residue [active]
362242001127	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819
362242001128	putative hydrophobic ligand binding site [chemical binding]; other site
362242001129	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819
362242001130	putative hydrophobic ligand binding site [chemical binding]; other site
362242001131	Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961
362242001132	Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038
362242001133	dimer interface [polypeptide binding]; other site
362242001134	PYR/PP interface [polypeptide binding]; other site
362242001135	TPP binding site [chemical binding]; other site
362242001136	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
362242001137	Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005
362242001138	TPP-binding site [chemical binding]; other site
362242001139	dimer interface [polypeptide binding]; other site
362242001140	Amidohydrolase; Region: Amidohydro_2; pfam04909
362242001141	Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481
362242001142	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
362242001143	enoyl-CoA hydratase; Provisional; Region: PRK06688
362242001144	substrate binding site [chemical binding]; other site
362242001145	oxyanion hole (OAH) forming residues; other site
362242001146	trimer interface [polypeptide binding]; other site
362242001147	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
362242001148	Cytochrome P450; Region: p450; cl12078
362242001149	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
362242001150	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
362242001151	NAD(P) binding site [chemical binding]; other site
362242001152	active site
362242001153	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
362242001154	Cytochrome P450; Region: p450; cl12078
362242001155	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
362242001156	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
362242001157	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
362242001158	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
362242001159	active site
362242001160	SnoaL-like domain; Region: SnoaL_4; pfam13577
362242001161	high affinity sulphate transporter 1; Region: sulP; TIGR00815
362242001162	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
362242001163	Sulfate transporter family; Region: Sulfate_transp; pfam00916
362242001164	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
362242001165	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
362242001166	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
362242001167	active site
362242001168	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
362242001169	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
362242001170	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
362242001171	Cytochrome P450; Region: p450; cl12078
362242001172	short chain dehydrogenase; Provisional; Region: PRK05876
362242001173	classical (c) SDRs; Region: SDR_c; cd05233
362242001174	NAD(P) binding site [chemical binding]; other site
362242001175	active site
362242001176	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
362242001177	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
362242001178	NAD(P) binding site [chemical binding]; other site
362242001179	active site
362242001180	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
362242001181	CoA-transferase family III; Region: CoA_transf_3; pfam02515
362242001182	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
362242001183	CoA-transferase family III; Region: CoA_transf_3; pfam02515
362242001184	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
362242001185	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
362242001186	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
362242001187	active site
362242001188	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
362242001189	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
362242001190	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
362242001191	active site
362242001192	Cytochrome P450; Region: p450; cl12078
362242001193	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
362242001194	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
362242001195	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
362242001196	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
362242001197	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
362242001198	NAD(P) binding site [chemical binding]; other site
362242001199	active site
362242001200	multidrug resistance protein MdtH; Provisional; Region: PRK11646
362242001201	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
362242001202	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
362242001203	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
362242001204	Multicopper oxidase; Region: Cu-oxidase; pfam00394
362242001205	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
362242001206	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
362242001207	TAP-like protein; Region: Abhydrolase_4; pfam08386
362242001208	Putative cyclase; Region: Cyclase; pfam04199
362242001209	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
362242001210	NAD(P) binding site [chemical binding]; other site
362242001211	3-alpha-hydroxysteroid dehydrogenase; Provisional; Region: PRK12428
362242001212	active site
362242001213	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
362242001214	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
362242001215	3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12835
362242001216	3-(2,3-dihydroxyphenyl)propionate dioxygenase; Provisional; Region: mhpB; PRK13370
362242001217	active site
362242001218	metal binding site [ion binding]; metal-binding site
362242001219	Transcriptional regulator [Transcription]; Region: IclR; COG1414
362242001220	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
362242001221	3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12844
362242001222	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
362242001223	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
362242001224	ATP binding site [chemical binding]; other site
362242001225	Mg2+ binding site [ion binding]; other site
362242001226	G-X-G motif; other site
362242001227	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
362242001228	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
362242001229	active site
362242001230	phosphorylation site [posttranslational modification]
362242001231	intermolecular recognition site; other site
362242001232	dimerization interface [polypeptide binding]; other site
362242001233	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
362242001234	DNA binding residues [nucleotide binding]
362242001235	dimerization interface [polypeptide binding]; other site
362242001236	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
362242001237	Major Facilitator Superfamily; Region: MFS_1; pfam07690
362242001238	putative substrate translocation pore; other site
362242001239	PE family; Region: PE; pfam00934
362242001240	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
362242001241	Walker A; other site
362242001242	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
362242001243	acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930
362242001244	dimer interface [polypeptide binding]; other site
362242001245	active site
362242001246	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
362242001247	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
362242001248	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
362242001249	substrate binding site [chemical binding]; other site
362242001250	oxyanion hole (OAH) forming residues; other site
362242001251	trimer interface [polypeptide binding]; other site
362242001252	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
362242001253	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
362242001254	active site
362242001255	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
362242001256	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
362242001257	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
362242001258	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
362242001259	acyl-activating enzyme (AAE) consensus motif; other site
362242001260	AMP binding site [chemical binding]; other site
362242001261	active site
362242001262	CoA binding site [chemical binding]; other site
362242001263	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
362242001264	catalytic loop [active]
362242001265	iron binding site [ion binding]; other site
362242001266	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
362242001267	CoA-transferase family III; Region: CoA_transf_3; pfam02515
362242001268	F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564
362242001269	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
362242001270	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
362242001271	B12 binding site [chemical binding]; other site
362242001272	cobalt ligand [ion binding]; other site
362242001273	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817
362242001274	Methyltransferase domain; Region: Methyltransf_31; pfam13847
362242001275	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
362242001276	S-adenosylmethionine binding site [chemical binding]; other site
362242001277	D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813
362242001278	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242001279	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242001280	Cellulose binding domain; Region: CBM_2; pfam00553
362242001281	CBD_II domain; Region: CBD_II; smart00637
362242001282	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
362242001283	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
362242001284	substrate binding pocket [chemical binding]; other site
362242001285	chain length determination region; other site
362242001286	substrate-Mg2+ binding site; other site
362242001287	catalytic residues [active]
362242001288	aspartate-rich region 1; other site
362242001289	active site lid residues [active]
362242001290	aspartate-rich region 2; other site
362242001291	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
362242001292	active site lid residues [active]
362242001293	substrate binding pocket [chemical binding]; other site
362242001294	catalytic residues [active]
362242001295	substrate-Mg2+ binding site; other site
362242001296	aspartate-rich region 1; other site
362242001297	aspartate-rich region 2; other site
362242001298	lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462
362242001299	lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462
362242001300	Transcriptional regulators [Transcription]; Region: MarR; COG1846
362242001301	MarR family; Region: MarR_2; pfam12802
362242001302	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
362242001303	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
362242001304	homotetramer interface [polypeptide binding]; other site
362242001305	FMN binding site [chemical binding]; other site
362242001306	homodimer contacts [polypeptide binding]; other site
362242001307	putative active site [active]
362242001308	putative substrate binding site [chemical binding]; other site
362242001309	RES domain; Region: RES; pfam08808
362242001310	Helix-turn-helix domain; Region: HTH_17; pfam12728
362242001311	L-asparagine permease; Provisional; Region: PRK15049
362242001312	threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672
362242001313	Predicted ATPase [General function prediction only]; Region: COG3911
362242001314	AAA domain; Region: AAA_28; pfam13521
362242001315	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242001316	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242001317	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242001318	Amidohydrolase; Region: Amidohydro_2; pfam04909
362242001319	PE family; Region: PE; pfam00934
362242001320	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
362242001321	DNA-binding site [nucleotide binding]; DNA binding site
362242001322	RNA-binding motif; other site
362242001323	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
362242001324	DEAD-like helicases superfamily; Region: DEXDc; smart00487
362242001325	ATP binding site [chemical binding]; other site
362242001326	putative Mg++ binding site [ion binding]; other site
362242001327	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
362242001328	nucleotide binding region [chemical binding]; other site
362242001329	ATP-binding site [chemical binding]; other site
362242001330	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
362242001331	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
362242001332	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
362242001333	substrate binding pocket [chemical binding]; other site
362242001334	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
362242001335	B12 binding site [chemical binding]; other site
362242001336	cobalt ligand [ion binding]; other site
362242001337	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
362242001338	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
362242001339	active site
362242001340	NTP binding site [chemical binding]; other site
362242001341	metal binding triad [ion binding]; metal-binding site
362242001342	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
362242001343	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242001344	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242001345	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
362242001346	PPE family; Region: PPE; pfam00823
362242001347	phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974
362242001348	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
362242001349	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
362242001350	putative active site [active]
362242001351	catalytic triad [active]
362242001352	Cupin domain; Region: Cupin_2; cl17218
362242001353	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
362242001354	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
362242001355	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
362242001356	Encapsulating protein for peroxidase; Region: Linocin_M18; cl17804
362242001357	Dyp-type peroxidase family; Region: Dyp_perox; pfam04261
362242001358	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
362242001359	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
362242001360	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
362242001361	dimerization interface [polypeptide binding]; other site
362242001362	ATP binding site [chemical binding]; other site
362242001363	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
362242001364	dimerization interface [polypeptide binding]; other site
362242001365	ATP binding site [chemical binding]; other site
362242001366	CAAX protease self-immunity; Region: Abi; pfam02517
362242001367	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
362242001368	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
362242001369	active site
362242001370	metal binding site [ion binding]; metal-binding site
362242001371	hexamer interface [polypeptide binding]; other site
362242001372	Protein of unknown function (DUF3184); Region: DUF3184; pfam11380
362242001373	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
362242001374	mce related protein; Region: MCE; pfam02470
362242001375	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
362242001376	amidophosphoribosyltransferase; Provisional; Region: PRK07847
362242001377	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
362242001378	active site
362242001379	tetramer interface [polypeptide binding]; other site
362242001380	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
362242001381	active site
362242001382	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
362242001383	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
362242001384	dimerization interface [polypeptide binding]; other site
362242001385	putative ATP binding site [chemical binding]; other site
362242001386	Protein of unknown function (DUF3073); Region: DUF3073; pfam11273
362242001387	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
362242001388	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
362242001389	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
362242001390	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
362242001391	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
362242001392	Soluble P-type ATPase [General function prediction only]; Region: COG4087
362242001393	Protein of unknown function (DUF1490); Region: DUF1490; pfam07371
362242001394	Thermus thermophilus CsoR, a Cu(I)-sensing transcriptional regulator, and related domains; this domain family was previously known as part of DUF156; Region: TthCsoR-like_DUF156; cd10151
362242001395	putative homodimer interface [polypeptide binding]; other site
362242001396	putative homotetramer interface [polypeptide binding]; other site
362242001397	allosteric switch controlling residues; other site
362242001398	putative metal binding site [ion binding]; other site
362242001399	putative homodimer-homodimer interface [polypeptide binding]; other site
362242001400	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
362242001401	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
362242001402	pyridoxal 5'-phosphate binding site [chemical binding]; other site
362242001403	catalytic residue [active]
362242001404	nitrobindin heme-binding domain; Region: nitrobindin; cd07828
362242001405	heme-binding site [chemical binding]; other site
362242001406	Protein of unknown function (DUF1416); Region: DUF1416; pfam07210
362242001407	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
362242001408	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
362242001409	active site residue [active]
362242001410	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
362242001411	active site residue [active]
362242001412	Domain of unknown function (DUF4395); Region: DUF4395; pfam14340
362242001413	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
362242001414	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
362242001415	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
362242001416	DNA binding site [nucleotide binding]
362242001417	mycothiol synthase; Region: mycothiol_MshD; TIGR03448
362242001418	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
362242001419	Coenzyme A binding pocket [chemical binding]; other site
362242001420	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
362242001421	Coenzyme A binding pocket [chemical binding]; other site
362242001422	PBP superfamily domain; Region: PBP_like_2; cl17296
362242001423	phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974
362242001424	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
362242001425	dimer interface [polypeptide binding]; other site
362242001426	conserved gate region; other site
362242001427	putative PBP binding loops; other site
362242001428	ABC-ATPase subunit interface; other site
362242001429	phosphate transporter ATP-binding protein; Provisional; Region: PRK14241
362242001430	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
362242001431	Walker A/P-loop; other site
362242001432	ATP binding site [chemical binding]; other site
362242001433	Q-loop/lid; other site
362242001434	ABC transporter signature motif; other site
362242001435	Walker B; other site
362242001436	D-loop; other site
362242001437	H-loop/switch region; other site
362242001438	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
362242001439	PhoU domain; Region: PhoU; pfam01895
362242001440	PhoU domain; Region: PhoU; pfam01895
362242001441	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
362242001442	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
362242001443	FMN binding site [chemical binding]; other site
362242001444	active site
362242001445	catalytic residues [active]
362242001446	substrate binding site [chemical binding]; other site
362242001447	Fatty acid desaturase; Region: FA_desaturase_2; pfam03405
362242001448	Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050
362242001449	homodimer interface [polypeptide binding]; other site
362242001450	putative substrate binding pocket [chemical binding]; other site
362242001451	diiron center [ion binding]; other site
362242001452	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
362242001453	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662
362242001454	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
362242001455	dimerization interface [polypeptide binding]; other site
362242001456	putative DNA binding site [nucleotide binding]; other site
362242001457	putative Zn2+ binding site [ion binding]; other site
362242001458	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
362242001459	nucleoside/Zn binding site; other site
362242001460	dimer interface [polypeptide binding]; other site
362242001461	catalytic motif [active]
362242001462	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
362242001463	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
362242001464	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242001465	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242001466	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242001467	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
362242001468	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
362242001469	Sulfatase; Region: Sulfatase; pfam00884
362242001470	putative OHCU decarboxylase; Provisional; Region: PRK13798
362242001471	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
362242001472	active site
362242001473	homotetramer interface [polypeptide binding]; other site
362242001474	FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941
362242001475	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
362242001476	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
362242001477	catalytic loop [active]
362242001478	iron binding site [ion binding]; other site
362242001479	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
362242001480	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
362242001481	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
362242001482	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
362242001483	hypothetical protein; Provisional; Region: PRK07236
362242001484	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
362242001485	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
362242001486	active site
362242001487	phosphorylation site [posttranslational modification]
362242001488	intermolecular recognition site; other site
362242001489	dimerization interface [polypeptide binding]; other site
362242001490	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
362242001491	DNA binding site [nucleotide binding]
362242001492	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
362242001493	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
362242001494	dimerization interface [polypeptide binding]; other site
362242001495	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
362242001496	dimer interface [polypeptide binding]; other site
362242001497	phosphorylation site [posttranslational modification]
362242001498	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
362242001499	ATP binding site [chemical binding]; other site
362242001500	Mg2+ binding site [ion binding]; other site
362242001501	G-X-G motif; other site
362242001502	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
362242001503	nucleotide binding site/active site [active]
362242001504	HIT family signature motif; other site
362242001505	catalytic residue [active]
362242001507	Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136
362242001508	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
362242001509	oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989
362242001510	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
362242001511	NAD binding site [chemical binding]; other site
362242001512	catalytic Zn binding site [ion binding]; other site
362242001513	substrate binding site [chemical binding]; other site
362242001514	structural Zn binding site [ion binding]; other site
362242001515	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
362242001516	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
362242001517	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
362242001518	Cytochrome P450; Region: p450; cl12078
362242001519	short chain dehydrogenase; Provisional; Region: PRK07775
362242001520	classical (c) SDRs; Region: SDR_c; cd05233
362242001521	NAD(P) binding site [chemical binding]; other site
362242001522	active site
362242001523	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
362242001524	Cytochrome P450; Region: p450; cl12078
362242001525	aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284
362242001526	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089
362242001527	NAD binding site [chemical binding]; other site
362242001528	catalytic residues [active]
362242001529	short chain dehydrogenase; Provisional; Region: PRK07774
362242001530	classical (c) SDRs; Region: SDR_c; cd05233
362242001531	NAD(P) binding site [chemical binding]; other site
362242001532	active site
362242001533	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
362242001534	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
362242001535	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
362242001536	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
362242001537	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
362242001538	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
362242001539	Catalytic domain of Protein Kinases; Region: PKc; cd00180
362242001540	active site
362242001541	ATP binding site [chemical binding]; other site
362242001542	substrate binding site [chemical binding]; other site
362242001543	activation loop (A-loop); other site
362242001544	Protein of unknown function (DUF732); Region: DUF732; pfam05305
362242001545	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
362242001546	Ligand Binding Site [chemical binding]; other site
362242001547	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
362242001548	Ligand Binding Site [chemical binding]; other site
362242001549	hypothetical protein; Provisional; Region: PRK07877
362242001550	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483
362242001551	ATP binding site [chemical binding]; other site
362242001552	substrate interface [chemical binding]; other site
362242001553	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242001554	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242001555	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242001556	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
362242001557	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
362242001558	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226
362242001559	Predicted nuclease (RNAse H fold) [General function prediction only]; Region: COG4328
362242001560	Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013
362242001561	Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015
362242001562	tetramer interface [polypeptide binding]; other site
362242001563	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
362242001564	Cytochrome P450; Region: p450; cl12078
362242001565	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
362242001566	PPE family; Region: PPE; pfam00823
362242001567	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
362242001568	Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116
362242001569	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
362242001570	NAD(P) binding site [chemical binding]; other site
362242001571	catalytic residues [active]
362242001572	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
362242001573	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
362242001574	NAD binding site [chemical binding]; other site
362242001575	substrate binding site [chemical binding]; other site
362242001576	catalytic Zn binding site [ion binding]; other site
362242001577	tetramer interface [polypeptide binding]; other site
362242001578	structural Zn binding site [ion binding]; other site
362242001579	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
362242001580	ATP binding site [chemical binding]; other site
362242001581	active site
362242001582	substrate binding site [chemical binding]; other site
362242001583	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
362242001584	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
362242001585	Predicted membrane protein [Function unknown]; Region: COG4270
362242001586	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
362242001587	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
362242001588	WHG domain; Region: WHG; pfam13305
362242001589	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
362242001590	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
362242001591	putative substrate translocation pore; other site
362242001592	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
362242001593	Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374
362242001594	Predicted deacetylase [General function prediction only]; Region: COG3233
362242001595	putative active site [active]
362242001596	putative Zn binding site [ion binding]; other site
362242001597	EamA-like transporter family; Region: EamA; pfam00892
362242001598	EamA-like transporter family; Region: EamA; pfam00892
362242001599	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242001600	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242001601	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242001604	Helix-turn-helix domain; Region: HTH_17; pfam12728
362242001605	PIN domain; Region: PIN_3; pfam13470
362242001606	Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400
362242001607	active site
362242001608	NTP binding site [chemical binding]; other site
362242001609	metal binding triad [ion binding]; metal-binding site
362242001610	Transposase, Mutator family; Region: Transposase_mut; pfam00872
362242001611	MULE transposase domain; Region: MULE; pfam10551
362242001612	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242001613	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242001614	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242001615	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
362242001616	nudix motif; other site
362242001617	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
362242001618	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
362242001619	DNA-binding site [nucleotide binding]; DNA binding site
362242001620	UTRA domain; Region: UTRA; pfam07702
362242001621	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
362242001622	Helix-turn-helix domain; Region: HTH_17; pfam12728
362242001623	Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973
362242001624	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
362242001625	active site
362242001626	DNA binding site [nucleotide binding]
362242001627	Int/Topo IB signature motif; other site
362242001628	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242001629	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242001630	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242001631	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
362242001632	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
362242001633	substrate binding site [chemical binding]; other site
362242001634	oxyanion hole (OAH) forming residues; other site
362242001635	trimer interface [polypeptide binding]; other site
362242001636	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242001637	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242001638	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242001640	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
362242001641	Amidase; Region: Amidase; cl11426
362242001642	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
362242001643	putative substrate translocation pore; other site
362242001644	Major Facilitator Superfamily; Region: MFS_1; pfam07690
362242001645	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
362242001646	2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832
362242001647	classical (c) SDRs; Region: SDR_c; cd05233
362242001648	NAD(P) binding site [chemical binding]; other site
362242001649	active site
362242001650	haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509
362242001651	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
362242001652	active site
362242001653	motif I; other site
362242001654	motif II; other site
362242001655	Methyltransferase domain; Region: Methyltransf_31; pfam13847
362242001656	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
362242001657	S-adenosylmethionine binding site [chemical binding]; other site
362242001658	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
362242001659	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242001660	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242001662	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
362242001663	trimer interface [polypeptide binding]; other site
362242001664	active site
362242001666	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
362242001667	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
362242001668	MDMPI C-terminal domain; Region: MDMPI_C; pfam07398
362242001669	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
362242001670	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
362242001671	substrate binding site; other site
362242001672	tetramer interface; other site
362242001673	PE family; Region: PE; pfam00934
362242001674	PE family; Region: PE; pfam00934
362242001675	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242001676	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242001677	PE family; Region: PE; pfam00934
362242001680	aminotransferase AlaT; Validated; Region: PRK09265
362242001681	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
362242001682	pyridoxal 5'-phosphate binding site [chemical binding]; other site
362242001683	homodimer interface [polypeptide binding]; other site
362242001684	catalytic residue [active]
362242001685	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
362242001686	4Fe-4S binding domain; Region: Fer4; pfam00037
362242001687	Cysteine-rich domain; Region: CCG; pfam02754
362242001688	Cysteine-rich domain; Region: CCG; pfam02754
362242001689	Transposase, Mutator family; Region: Transposase_mut; pfam00872
362242001690	MULE transposase domain; Region: MULE; pfam10551
362242001691	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242001692	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242001693	Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699
362242001694	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
362242001695	G1 box; other site
362242001696	GTP/Mg2+ binding site [chemical binding]; other site
362242001697	G2 box; other site
362242001698	Switch I region; other site
362242001699	G3 box; other site
362242001700	Switch II region; other site
362242001701	G4 box; other site
362242001702	G5 box; other site
362242001703	Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699
362242001704	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
362242001705	G1 box; other site
362242001706	GTP/Mg2+ binding site [chemical binding]; other site
362242001707	G2 box; other site
362242001708	Switch I region; other site
362242001709	G3 box; other site
362242001710	Switch II region; other site
362242001711	G4 box; other site
362242001712	G5 box; other site
362242001713	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
362242001716	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
362242001717	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
362242001718	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
362242001719	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
362242001720	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
362242001721	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
362242001722	active site
362242001723	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
362242001724	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
362242001725	nucleotide binding site [chemical binding]; other site
362242001726	NEF interaction site [polypeptide binding]; other site
362242001727	SBD interface [polypeptide binding]; other site
362242001728	GrpE; Region: GrpE; pfam01025
362242001729	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
362242001730	dimer interface [polypeptide binding]; other site
362242001731	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
362242001732	chaperone protein DnaJ; Provisional; Region: PRK14279
362242001733	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
362242001734	HSP70 interaction site [polypeptide binding]; other site
362242001735	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
362242001736	Zn binding sites [ion binding]; other site
362242001737	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
362242001738	dimer interface [polypeptide binding]; other site
362242001739	Helix-Turn-Helix DNA binding domain of HspR-like transcription regulators; Region: HTH_HspR-like; cd01279
362242001740	DNA binding residues [nucleotide binding]
362242001741	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
362242001742	putative dimer interface [polypeptide binding]; other site
362242001743	Transposase, Mutator family; Region: Transposase_mut; pfam00872
362242001744	MULE transposase domain; Region: MULE; pfam10551
362242001745	Transposase, Mutator family; Region: Transposase_mut; pfam00872
362242001746	MULE transposase domain; Region: MULE; pfam10551
362242001747	Cytochrome P450; Region: p450; cl12078
362242001748	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
362242001749	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
362242001750	anti sigma factor interaction site; other site
362242001751	regulatory phosphorylation site [posttranslational modification]; other site
362242001752	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
362242001753	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
362242001754	active site
362242001755	catalytic triad [active]
362242001756	oxyanion hole [active]
362242001757	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
362242001758	Putative esterase; Region: Esterase; pfam00756
362242001759	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
362242001760	Ligand Binding Site [chemical binding]; other site
362242001761	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
362242001762	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
362242001763	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
362242001764	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
362242001765	Soluble P-type ATPase [General function prediction only]; Region: COG4087
362242001766	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
362242001767	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242001768	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242001769	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242001770	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
362242001771	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
362242001772	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
362242001773	Domain of unknown function (DUF427); Region: DUF427; pfam04248
362242001774	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
362242001775	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
362242001776	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
362242001777	inhibitor-cofactor binding pocket; inhibition site
362242001778	pyridoxal 5'-phosphate binding site [chemical binding]; other site
362242001779	catalytic residue [active]
362242001780	Broad specificity phosphatase PhoE and related phosphatases [General function prediction only]; Region: phoE; COG0406
362242001781	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
362242001782	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
362242001783	catalytic residues [active]
362242001784	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
362242001785	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
362242001786	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333
362242001787	ResB-like family; Region: ResB; pfam05140
362242001788	cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144
362242001789	Protein of unknown function (DUF4229); Region: DUF4229; pfam14012
362242001790	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
362242001791	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
362242001792	dimer interface [polypeptide binding]; other site
362242001793	active site
362242001794	CoA binding pocket [chemical binding]; other site
362242001795	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
362242001796	UbiA prenyltransferase family; Region: UbiA; pfam01040
362242001797	5'-methylthioadenosine phosphorylase; Validated; Region: PRK07823
362242001798	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
362242001799	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
362242001800	NAD(P) binding site [chemical binding]; other site
362242001801	active site
362242001802	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
362242001803	Ligand binding site; other site
362242001804	Putative Catalytic site; other site
362242001805	DXD motif; other site
362242001806	Uncharacterized protein conserved in bacteria (DUF2064); Region: DUF2064; cl17492
362242001807	O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824
362242001808	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
362242001809	acyl-activating enzyme (AAE) consensus motif; other site
362242001810	AMP binding site [chemical binding]; other site
362242001811	active site
362242001812	CoA binding site [chemical binding]; other site
362242001813	Protein of unknown function (DUF3349); Region: DUF3349; pfam11829
362242001814	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
362242001815	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
362242001816	active site
362242001817	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
362242001818	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
362242001819	short chain dehydrogenase; Provisional; Region: PRK05866
362242001820	classical (c) SDRs; Region: SDR_c; cd05233
362242001821	NAD(P) binding site [chemical binding]; other site
362242001822	active site
362242001823	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
362242001824	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
362242001825	substrate binding site [chemical binding]; other site
362242001826	oxyanion hole (OAH) forming residues; other site
362242001827	trimer interface [polypeptide binding]; other site
362242001828	acyl-CoA synthetase; Validated; Region: PRK06188
362242001829	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
362242001830	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
362242001831	putative active site [active]
362242001832	putative CoA binding site [chemical binding]; other site
362242001833	putative AMP binding site [chemical binding]; other site
362242001834	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
362242001835	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
362242001836	active site
362242001837	O-succinylbenzoate synthase; Provisional; Region: PRK02901
362242001838	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
362242001839	metal binding site [ion binding]; metal-binding site
362242001840	substrate binding pocket [chemical binding]; other site
362242001841	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
362242001842	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
362242001843	TAP-like protein; Region: Abhydrolase_4; pfam08386
362242001844	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449
362242001845	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
362242001846	dimer interface [polypeptide binding]; other site
362242001847	tetramer interface [polypeptide binding]; other site
362242001848	PYR/PP interface [polypeptide binding]; other site
362242001849	TPP binding site [chemical binding]; other site
362242001850	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
362242001851	TPP-binding site; other site
362242001852	Protein of unknown function (DUF3592); Region: DUF3592; pfam12158
362242001853	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
362242001854	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
362242001855	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
362242001856	MarR family; Region: MarR; pfam01047
362242001857	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
362242001858	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
362242001859	S-adenosylmethionine binding site [chemical binding]; other site
362242001860	Protein of unknown function (DUF732); Region: DUF732; pfam05305
362242001861	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
362242001862	S-adenosylmethionine binding site [chemical binding]; other site
362242001863	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
362242001864	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
362242001865	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
362242001866	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
362242001867	substrate binding pocket [chemical binding]; other site
362242001868	chain length determination region; other site
362242001869	substrate-Mg2+ binding site; other site
362242001870	catalytic residues [active]
362242001871	aspartate-rich region 1; other site
362242001872	active site lid residues [active]
362242001873	aspartate-rich region 2; other site
362242001874	heat shock protein HtpX; Provisional; Region: PRK03072
362242001875	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
362242001876	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
362242001877	Sulfate transporter family; Region: Sulfate_transp; pfam00916
362242001878	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
362242001879	Sulfate transporter family; Region: Sulfate_transp; pfam00916
362242001880	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK12439
362242001881	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
362242001882	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
362242001883	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
362242001884	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
362242001885	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
362242001886	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
362242001887	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
362242001888	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
362242001889	FtsX-like permease family; Region: FtsX; pfam02687
362242001890	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
362242001891	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
362242001892	Walker A/P-loop; other site
362242001893	ATP binding site [chemical binding]; other site
362242001894	Q-loop/lid; other site
362242001895	ABC transporter signature motif; other site
362242001896	Walker B; other site
362242001897	D-loop; other site
362242001898	H-loop/switch region; other site
362242001899	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
362242001900	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
362242001901	oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971
362242001902	classical (c) SDRs; Region: SDR_c; cd05233
362242001903	NAD(P) binding site [chemical binding]; other site
362242001904	active site
362242001905	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
362242001906	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242001907	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242001908	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242001909	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
362242001910	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
362242001911	O-methyltransferase; Region: Methyltransf_2; pfam00891
362242001912	LIM is a small protein-protein interaction domain, containing two zinc fingers; Region: LIM; cl02475
362242001913	Zn binding site [ion binding]; other site
362242001914	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
362242001915	cyclase homology domain; Region: CHD; cd07302
362242001916	nucleotidyl binding site; other site
362242001917	metal binding site [ion binding]; metal-binding site
362242001918	dimer interface [polypeptide binding]; other site
362242001919	amidase; Provisional; Region: PRK08137
362242001920	Amidase; Region: Amidase; cl11426
362242001921	hypothetical protein; Provisional; Region: PRK07588
362242001922	Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085
362242001923	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
362242001924	nucleotide binding site/active site [active]
362242001925	HIT family signature motif; other site
362242001926	catalytic residue [active]
362242001927	galactokinase; Provisional; Region: PRK00555
362242001928	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
362242001929	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
362242001930	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
362242001931	putative hydrophobic ligand binding site [chemical binding]; other site
362242001932	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
362242001933	TIGR03086 family protein; Region: TIGR03086
362242001936	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
362242001937	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
362242001938	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
362242001939	Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738
362242001940	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
362242001941	Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299
362242001942	Amidohydrolase; Region: Amidohydro_4; pfam13147
362242001943	active site
362242001944	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
362242001945	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
362242001946	exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447
362242001947	AAA domain; Region: AAA_30; pfam13604
362242001948	Family description; Region: UvrD_C_2; pfam13538
362242001949	exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609
362242001950	Part of AAA domain; Region: AAA_19; pfam13245
362242001951	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
362242001952	exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450
362242001953	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
362242001954	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
362242001955	FMN binding site [chemical binding]; other site
362242001956	dimer interface [polypeptide binding]; other site
362242001957	cyanate hydratase; Validated; Region: PRK02866
362242001958	Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate.  It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559
362242001959	oligomer interface [polypeptide binding]; other site
362242001960	active site
362242001961	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
362242001962	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
362242001963	substrate binding site [chemical binding]; other site
362242001964	oxyanion hole (OAH) forming residues; other site
362242001965	trimer interface [polypeptide binding]; other site
362242001966	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
362242001967	Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957
362242001968	50S ribosomal protein L33; Validated; Region: rpmG; PRK00504
362242001969	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
362242001970	active site
362242001971	catalytic site [active]
362242001972	SAV4209_like.  Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453
362242001973	active site
362242001974	catalytic site [active]
362242001975	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
362242001976	active site
362242001977	catalytic site [active]
362242001978	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
362242001979	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
362242001980	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
362242001981	putative homodimer interface [polypeptide binding]; other site
362242001982	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
362242001983	heterodimer interface [polypeptide binding]; other site
362242001984	homodimer interface [polypeptide binding]; other site
362242001985	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
362242001986	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
362242001987	23S rRNA interface [nucleotide binding]; other site
362242001988	L7/L12 interface [polypeptide binding]; other site
362242001989	putative thiostrepton binding site; other site
362242001990	L25 interface [polypeptide binding]; other site
362242001991	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
362242001992	mRNA/rRNA interface [nucleotide binding]; other site
362242001993	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
362242001994	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
362242001995	S-adenosylmethionine binding site [chemical binding]; other site
362242001996	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
362242001997	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
362242001998	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
362242001999	S-adenosylmethionine binding site [chemical binding]; other site
362242002000	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
362242002001	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
362242002002	S-adenosylmethionine binding site [chemical binding]; other site
362242002003	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
362242002004	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
362242002005	ABC1 family; Region: ABC1; pfam03109
362242002006	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
362242002007	active site
362242002008	ATP binding site [chemical binding]; other site
362242002009	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
362242002010	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
362242002011	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
362242002012	TAP-like protein; Region: Abhydrolase_4; pfam08386
362242002013	N-terminal catalytic domain of class II alpha-mannosidases and similar proteins; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_like; cd10786
362242002014	active site
362242002015	catalytic site [active]
362242002016	Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383
362242002017	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872
362242002018	NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633
362242002019	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
362242002020	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
362242002021	nucleotide binding site [chemical binding]; other site
362242002022	PE family; Region: PE; pfam00934
362242002023	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
362242002024	23S rRNA interface [nucleotide binding]; other site
362242002025	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
362242002026	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
362242002027	core dimer interface [polypeptide binding]; other site
362242002028	peripheral dimer interface [polypeptide binding]; other site
362242002029	L10 interface [polypeptide binding]; other site
362242002030	L11 interface [polypeptide binding]; other site
362242002031	putative EF-Tu interaction site [polypeptide binding]; other site
362242002032	putative EF-G interaction site [polypeptide binding]; other site
362242002033	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
362242002034	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
362242002035	WHG domain; Region: WHG; pfam13305
362242002036	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
362242002037	Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055
362242002038	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
362242002039	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
362242002040	Walker A/P-loop; other site
362242002041	ATP binding site [chemical binding]; other site
362242002042	Q-loop/lid; other site
362242002043	ABC transporter signature motif; other site
362242002044	Walker B; other site
362242002045	D-loop; other site
362242002046	H-loop/switch region; other site
362242002047	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
362242002048	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
362242002049	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
362242002050	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
362242002051	RPB10 interaction site [polypeptide binding]; other site
362242002052	RPB1 interaction site [polypeptide binding]; other site
362242002053	RPB11 interaction site [polypeptide binding]; other site
362242002054	RPB3 interaction site [polypeptide binding]; other site
362242002055	RPB12 interaction site [polypeptide binding]; other site
362242002056	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
362242002057	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
362242002058	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
362242002059	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
362242002060	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
362242002061	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
362242002062	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
362242002063	G-loop; other site
362242002064	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
362242002065	DNA binding site [nucleotide binding]
362242002066	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
362242002067	endonuclease IV; Provisional; Region: PRK01060
362242002068	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
362242002069	AP (apurinic/apyrimidinic) site pocket; other site
362242002070	DNA interaction; other site
362242002071	Metal-binding active site; metal-binding site
362242002072	Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509
362242002073	isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561
362242002074	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
362242002075	active site
362242002076	enoyl-CoA hydratase; Provisional; Region: PRK12478
362242002077	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
362242002078	substrate binding site [chemical binding]; other site
362242002079	oxyanion hole (OAH) forming residues; other site
362242002080	trimer interface [polypeptide binding]; other site
362242002081	PaaX-like protein; Region: PaaX; pfam07848
362242002082	PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223
362242002083	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
362242002084	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
362242002085	substrate binding site [chemical binding]; other site
362242002086	oxyanion hole (OAH) forming residues; other site
362242002087	trimer interface [polypeptide binding]; other site
362242002088	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
362242002089	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
362242002090	Protein of unknown function (DUF3060); Region: DUF3060; pfam11259
362242002091	Protein of unknown function (DUF3060); Region: DUF3060; pfam11259
362242002092	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
362242002093	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
362242002094	WHG domain; Region: WHG; pfam13305
362242002095	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
362242002096	S17 interaction site [polypeptide binding]; other site
362242002097	S8 interaction site; other site
362242002098	16S rRNA interaction site [nucleotide binding]; other site
362242002099	streptomycin interaction site [chemical binding]; other site
362242002100	23S rRNA interaction site [nucleotide binding]; other site
362242002101	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
362242002102	30S ribosomal protein S7; Validated; Region: PRK05302
362242002103	elongation factor G; Reviewed; Region: PRK00007
362242002104	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
362242002105	G1 box; other site
362242002106	putative GEF interaction site [polypeptide binding]; other site
362242002107	GTP/Mg2+ binding site [chemical binding]; other site
362242002108	Switch I region; other site
362242002109	G2 box; other site
362242002110	G3 box; other site
362242002111	Switch II region; other site
362242002112	G4 box; other site
362242002113	G5 box; other site
362242002114	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
362242002115	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
362242002116	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
362242002117	elongation factor Tu; Reviewed; Region: PRK00049
362242002118	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
362242002119	G1 box; other site
362242002120	GEF interaction site [polypeptide binding]; other site
362242002121	GTP/Mg2+ binding site [chemical binding]; other site
362242002122	Switch I region; other site
362242002123	G2 box; other site
362242002124	G3 box; other site
362242002125	Switch II region; other site
362242002126	G4 box; other site
362242002127	G5 box; other site
362242002128	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
362242002129	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
362242002130	Antibiotic Binding Site [chemical binding]; other site
362242002131	Short C-terminal domain; Region: SHOCT; pfam09851
362242002132	oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971
362242002133	classical (c) SDRs; Region: SDR_c; cd05233
362242002134	NAD(P) binding site [chemical binding]; other site
362242002135	active site
362242002136	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
362242002137	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
362242002138	Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; pfam10094
362242002139	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
362242002140	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
362242002141	putative mycofactocin binding protein MftB; Region: mycofact_MftB; TIGR03967
362242002142	mycofactocin radical SAM maturase; Region: mycofact_rSAM; TIGR03962
362242002143	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
362242002144	FeS/SAM binding site; other site
362242002145	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
362242002146	heme/flavin dehydrogenase, mycofactocin system; Region: actino_HemFlav; TIGR03966
362242002147	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
362242002148	phosphate binding site [ion binding]; other site
362242002149	mycofactocin system creatininase family protein; Region: mycofact_creat; TIGR03964
362242002150	mycofactocin system glycosyltransferase; Region: mycofact_glyco; TIGR03965
362242002151	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
362242002152	active site
362242002153	dehydrogenase, Rv0697 family; Region: Rv0697; TIGR03970
362242002154	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
362242002155	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
362242002156	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
362242002157	sequence-specific DNA binding site [nucleotide binding]; other site
362242002158	salt bridge; other site
362242002159	Transposase, Mutator family; Region: Transposase_mut; pfam00872
362242002160	MULE transposase domain; Region: MULE; pfam10551
362242002161	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242002162	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242002163	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242002164	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
362242002165	PPE family; Region: PPE; pfam00823
362242002166	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
362242002167	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
362242002168	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
362242002169	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242002170	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242002171	Secretory lipase; Region: LIP; pfam03583
362242002172	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
362242002173	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
362242002174	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
362242002175	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
362242002176	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
362242002177	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
362242002178	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
362242002179	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
362242002180	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
362242002181	putative translocon binding site; other site
362242002182	protein-rRNA interface [nucleotide binding]; other site
362242002183	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
362242002184	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
362242002185	G-X-X-G motif; other site
362242002186	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
362242002187	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
362242002188	23S rRNA interface [nucleotide binding]; other site
362242002189	5S rRNA interface [nucleotide binding]; other site
362242002190	putative antibiotic binding site [chemical binding]; other site
362242002191	L25 interface [polypeptide binding]; other site
362242002192	L27 interface [polypeptide binding]; other site
362242002193	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
362242002194	L23 interface [polypeptide binding]; other site
362242002195	signal recognition particle (SRP54) interaction site; other site
362242002196	trigger factor interaction site; other site
362242002197	23S rRNA interface [nucleotide binding]; other site
362242002198	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
362242002199	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
362242002200	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
362242002201	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
362242002202	RNA binding site [nucleotide binding]; other site
362242002203	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
362242002204	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
362242002205	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
362242002206	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
362242002207	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
362242002208	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
362242002209	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
362242002210	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
362242002211	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
362242002212	5S rRNA interface [nucleotide binding]; other site
362242002213	23S rRNA interface [nucleotide binding]; other site
362242002214	L5 interface [polypeptide binding]; other site
362242002215	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
362242002216	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
362242002217	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
362242002218	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
362242002219	23S rRNA binding site [nucleotide binding]; other site
362242002220	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
362242002221	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
362242002222	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
362242002223	tandem repeat interface [polypeptide binding]; other site
362242002224	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
362242002225	oligomer interface [polypeptide binding]; other site
362242002226	active site residues [active]
362242002227	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
362242002228	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
362242002229	tandem repeat interface [polypeptide binding]; other site
362242002230	oligomer interface [polypeptide binding]; other site
362242002231	active site residues [active]
362242002232	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
362242002233	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
362242002234	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
362242002235	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
362242002236	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
362242002237	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
362242002238	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
362242002239	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
362242002240	NAD(P) binding site [chemical binding]; other site
362242002241	active site
362242002242	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
362242002243	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
362242002244	NAD(P) binding site [chemical binding]; other site
362242002245	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
362242002246	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
362242002247	S-adenosylmethionine binding site [chemical binding]; other site
362242002248	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
362242002249	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
362242002250	L-fuculose-phosphate aldolase; Validated; Region: PRK05874
362242002251	intersubunit interface [polypeptide binding]; other site
362242002252	active site
362242002253	Zn2+ binding site [ion binding]; other site
362242002254	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
362242002255	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
362242002256	NAD binding site [chemical binding]; other site
362242002257	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
362242002258	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
362242002259	nucleotide binding site [chemical binding]; other site
362242002260	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
362242002261	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
362242002262	Coenzyme A binding pocket [chemical binding]; other site
362242002263	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
362242002264	SecY translocase; Region: SecY; pfam00344
362242002265	adenylate kinase; Reviewed; Region: adk; PRK00279
362242002266	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
362242002267	AMP-binding site [chemical binding]; other site
362242002268	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
362242002269	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
362242002270	active site
362242002271	RNA polymerase sigma factor SigL; Provisional; Region: PRK09645
362242002272	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
362242002273	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
362242002274	DNA binding residues [nucleotide binding]
362242002275	Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662
362242002276	Putative zinc-finger; Region: zf-HC2; pfam13490
362242002277	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
362242002278	MarR family; Region: MarR; pfam01047
362242002279	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
362242002280	TIGR03086 family protein; Region: TIGR03086
362242002281	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
362242002282	3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692
362242002283	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
362242002284	Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162
362242002285	substrate binding pocket [chemical binding]; other site
362242002286	FAD binding site [chemical binding]; other site
362242002287	catalytic base [active]
362242002288	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
362242002289	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
362242002290	tetrameric interface [polypeptide binding]; other site
362242002291	NAD binding site [chemical binding]; other site
362242002292	catalytic residues [active]
362242002293	methyl viologen resistance protein SmvA; Provisional; Region: PRK14995
362242002294	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
362242002295	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
362242002296	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
362242002297	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
362242002298	NAD binding site [chemical binding]; other site
362242002299	substrate binding site [chemical binding]; other site
362242002300	homodimer interface [polypeptide binding]; other site
362242002301	active site
362242002302	probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620
362242002303	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
362242002304	probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620
362242002305	F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564
362242002306	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
362242002307	rRNA binding site [nucleotide binding]; other site
362242002308	predicted 30S ribosome binding site; other site
362242002309	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
362242002310	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
362242002311	30S ribosomal protein S13; Region: bact_S13; TIGR03631
362242002312	30S ribosomal protein S11; Validated; Region: PRK05309
362242002313	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
362242002314	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
362242002315	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
362242002316	RNA binding surface [nucleotide binding]; other site
362242002317	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
362242002318	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
362242002319	alphaNTD homodimer interface [polypeptide binding]; other site
362242002320	alphaNTD - beta interaction site [polypeptide binding]; other site
362242002321	alphaNTD - beta' interaction site [polypeptide binding]; other site
362242002322	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
362242002323	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
362242002324	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
362242002325	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
362242002326	active site
362242002327	dimerization interface 3.5A [polypeptide binding]; other site
362242002328	D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049
362242002329	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
362242002330	PPE family; Region: PPE; pfam00823
362242002331	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
362242002332	Cutinase; Region: Cutinase; pfam01083
362242002333	Cutinase; Region: Cutinase; pfam01083
362242002334	type VII secretion protein EccB, Actinobacterial; Region: T7SS_EccB; TIGR03919
362242002335	type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921
362242002336	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
362242002337	active site
362242002338	catalytic residues [active]
362242002339	WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489
362242002340	type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924
362242002341	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
362242002342	type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925
362242002343	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
362242002344	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
362242002345	type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931
362242002346	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842
362242002347	Proteins of 100 residues with WXG; Region: WXG100; cl02005
362242002348	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
362242002349	23S rRNA interface [nucleotide binding]; other site
362242002350	L3 interface [polypeptide binding]; other site
362242002351	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
362242002352	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318
362242002353	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
362242002354	active site
362242002355	substrate binding site [chemical binding]; other site
362242002356	metal binding site [ion binding]; metal-binding site
362242002357	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
362242002358	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
362242002359	glutaminase active site [active]
362242002360	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
362242002361	dimer interface [polypeptide binding]; other site
362242002362	active site
362242002363	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
362242002364	dimer interface [polypeptide binding]; other site
362242002365	active site
362242002366	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242002367	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242002368	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242002369	Uncharacterized conserved protein [Function unknown]; Region: COG0062
362242002370	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
362242002371	putative substrate binding site [chemical binding]; other site
362242002372	putative ATP binding site [chemical binding]; other site
362242002373	DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450
362242002374	pyridoxal 5'-phosphate binding site [chemical binding]; other site
362242002375	catalytic residue [active]
362242002376	alanine racemase; Reviewed; Region: alr; PRK00053
362242002377	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
362242002378	active site
362242002379	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
362242002380	dimer interface [polypeptide binding]; other site
362242002381	substrate binding site [chemical binding]; other site
362242002382	catalytic residues [active]
362242002383	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
362242002384	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
362242002385	Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; pfam02367
362242002386	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214
362242002387	Glycoprotease family; Region: Peptidase_M22; pfam00814
362242002388	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
362242002389	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
362242002390	Coenzyme A binding pocket [chemical binding]; other site
362242002391	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
362242002392	UGMP family protein; Validated; Region: PRK09604
362242002393	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
362242002394	oligomerisation interface [polypeptide binding]; other site
362242002395	mobile loop; other site
362242002396	roof hairpin; other site
362242002397	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
362242002398	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
362242002399	ring oligomerisation interface [polypeptide binding]; other site
362242002400	ATP/Mg binding site [chemical binding]; other site
362242002401	stacking interactions; other site
362242002402	hinge regions; other site
362242002403	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242002404	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242002405	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242002406	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
362242002407	PPE family; Region: PPE; pfam00823
362242002408	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
362242002409	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
362242002410	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
362242002411	active site
362242002412	Transcription factor WhiB; Region: Whib; pfam02467
362242002413	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242002414	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242002415	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242002416	RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648
362242002417	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
362242002418	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
362242002419	DNA binding residues [nucleotide binding]
362242002420	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
362242002421	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
362242002422	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
362242002423	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
362242002424	active site
362242002425	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649
362242002426	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
362242002427	phosphate binding site [ion binding]; other site
362242002428	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
362242002429	PPE family; Region: PPE; pfam00823
362242002430	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
362242002431	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
362242002432	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
362242002433	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
362242002434	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
362242002435	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
362242002436	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
362242002437	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
362242002438	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
362242002439	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
362242002440	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
362242002441	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
362242002442	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242002443	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242002444	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242002445	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
362242002446	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
362242002447	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
362242002448	methyl viologen resistance protein SmvA; Provisional; Region: PRK14995
362242002449	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
362242002450	putative substrate translocation pore; other site
362242002451	Predicted transcriptional regulators [Transcription]; Region: COG1733
362242002452	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
362242002453	dimerization interface [polypeptide binding]; other site
362242002454	putative DNA binding site [nucleotide binding]; other site
362242002455	putative Zn2+ binding site [ion binding]; other site
362242002456	GMP synthase; Reviewed; Region: guaA; PRK00074
362242002457	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
362242002458	AMP/PPi binding site [chemical binding]; other site
362242002459	candidate oxyanion hole; other site
362242002460	catalytic triad [active]
362242002461	potential glutamine specificity residues [chemical binding]; other site
362242002462	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
362242002463	ATP Binding subdomain [chemical binding]; other site
362242002464	Ligand Binding sites [chemical binding]; other site
362242002465	Dimerization subdomain; other site
362242002466	DNA Polymerase Y-family; Region: PolY_like; cd03468
362242002467	active site
362242002468	DNA binding site [nucleotide binding]
362242002469	short chain dehydrogenase; Provisional; Region: PRK07201
362242002470	Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263
362242002471	putative NAD(P) binding site [chemical binding]; other site
362242002472	active site
362242002473	putative substrate binding site [chemical binding]; other site
362242002474	classical (c) SDRs; Region: SDR_c; cd05233
362242002475	NAD(P) binding site [chemical binding]; other site
362242002476	active site
362242002477	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
362242002478	catalytic core [active]
362242002479	enoyl-CoA hydratase; Region: PLN02864
362242002480	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
362242002481	HDE_HSD  The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins.  Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448
362242002482	dimer interaction site [polypeptide binding]; other site
362242002483	substrate-binding tunnel; other site
362242002484	active site
362242002485	catalytic site [active]
362242002486	substrate binding site [chemical binding]; other site
362242002487	Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877
362242002488	trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105
362242002489	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
362242002490	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
362242002491	active site
362242002492	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
362242002493	generic binding surface II; other site
362242002494	generic binding surface I; other site
362242002495	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242002496	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242002497	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242002498	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
362242002499	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
362242002500	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
362242002501	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
362242002502	Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123
362242002503	delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236
362242002504	Glutamate binding site [chemical binding]; other site
362242002505	NAD binding site [chemical binding]; other site
362242002506	catalytic residues [active]
362242002507	Proline dehydrogenase; Region: Pro_dh; cl03282
362242002508	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
362242002509	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
362242002510	lipid-transfer protein; Provisional; Region: PRK07855
362242002511	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
362242002512	active site
362242002513	SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  The alpha- and...; Region: SAV4209; cd03455
362242002514	putative active site [active]
362242002515	putative catalytic site [active]
362242002516	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
362242002517	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
362242002518	DUF35 OB-fold domain; Region: DUF35; pfam01796
362242002519	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
362242002520	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
362242002521	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
362242002522	NAD(P) binding site [chemical binding]; other site
362242002523	catalytic residues [active]
362242002524	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
362242002525	PGAP1-like protein; Region: PGAP1; pfam07819
362242002526	acyl-CoA synthetase; Validated; Region: PRK07787
362242002527	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
362242002528	acyl-activating enzyme (AAE) consensus motif; other site
362242002529	AMP binding site [chemical binding]; other site
362242002530	active site
362242002531	CoA binding site [chemical binding]; other site
362242002532	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
362242002533	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
362242002534	PE family; Region: PE; pfam00934
362242002535	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
362242002536	PPE family; Region: PPE; pfam00823
362242002537	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
362242002538	metabolite-proton symporter; Region: 2A0106; TIGR00883
362242002539	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
362242002540	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242002541	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242002542	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242002543	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
362242002544	putative DNA binding site [nucleotide binding]; other site
362242002545	putative Zn2+ binding site [ion binding]; other site
362242002546	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535
362242002547	Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649
362242002548	putative trimer interface [polypeptide binding]; other site
362242002549	putative CoA binding site [chemical binding]; other site
362242002550	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007
362242002551	M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647
362242002552	metal binding site [ion binding]; metal-binding site
362242002553	putative dimer interface [polypeptide binding]; other site
362242002554	AAA ATPase domain; Region: AAA_16; pfam13191
362242002555	TIGR00730 family protein; Region: TIGR00730
362242002556	long-chain-acyl-CoA synthetase; Validated; Region: PRK08279
362242002557	Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940
362242002558	acyl-activating enzyme (AAE) consensus motif; other site
362242002559	putative AMP binding site [chemical binding]; other site
362242002560	putative active site [active]
362242002561	putative CoA binding site [chemical binding]; other site
362242002562	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
362242002563	dihydropteroate synthase; Region: DHPS; TIGR01496
362242002564	substrate binding pocket [chemical binding]; other site
362242002565	dimer interface [polypeptide binding]; other site
362242002566	inhibitor binding site; inhibition site
362242002567	putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915
362242002568	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
362242002569	DivIVA domain; Region: DivI1A_domain; TIGR03544
362242002570	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
362242002571	Protein of unknown function (DUF3117); Region: DUF3117; pfam11314
362242002572	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
362242002573	PPE family; Region: PPE; pfam00823
362242002574	PPE family; Region: PPE; pfam00823
362242002575	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
362242002576	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
362242002577	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
362242002578	Transposase, Mutator family; Region: Transposase_mut; pfam00872
362242002579	MULE transposase domain; Region: MULE; pfam10551
362242002580	PE family; Region: PE; pfam00934
362242002581	PE-PPE domain; Region: PE-PPE; pfam08237
362242002582	acetyl-CoA acetyltransferase; Provisional; Region: PRK07801
362242002583	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
362242002584	dimer interface [polypeptide binding]; other site
362242002585	active site
362242002586	enoyl-CoA hydratase; Provisional; Region: PRK08252
362242002587	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
362242002588	substrate binding site [chemical binding]; other site
362242002589	oxyanion hole (OAH) forming residues; other site
362242002590	trimer interface [polypeptide binding]; other site
362242002592	Transposase, Mutator family; Region: Transposase_mut; pfam00872
362242002593	MULE transposase domain; Region: MULE; pfam10551
362242002594	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242002595	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242002596	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242002597	Transposase, Mutator family; Region: Transposase_mut; pfam00872
362242002598	MULE transposase domain; Region: MULE; pfam10551
362242002599	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
362242002600	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755
362242002601	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
362242002602	NADH(P)-binding; Region: NAD_binding_10; pfam13460
362242002603	NAD(P) binding site [chemical binding]; other site
362242002604	active site
362242002605	CAAX protease self-immunity; Region: Abi; pfam02517
362242002606	enoyl-CoA hydratase; Provisional; Region: PRK06688
362242002607	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
362242002608	substrate binding site [chemical binding]; other site
362242002609	oxyanion hole (OAH) forming residues; other site
362242002610	trimer interface [polypeptide binding]; other site
362242002611	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
362242002612	CoA-transferase family III; Region: CoA_transf_3; pfam02515
362242002613	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217
362242002614	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
362242002615	NAD(P) binding site [chemical binding]; other site
362242002616	active site
362242002617	MMPL family; Region: MMPL; pfam03176
362242002618	MMPL family; Region: MMPL; pfam03176
362242002619	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
362242002620	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
362242002621	WHG domain; Region: WHG; pfam13305
362242002622	Methyltransferase domain; Region: Methyltransf_23; pfam13489
362242002623	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
362242002624	S-adenosylmethionine binding site [chemical binding]; other site
362242002625	NAD-dependent deacetylase; Provisional; Region: PRK00481
362242002626	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
362242002627	NAD+ binding site [chemical binding]; other site
362242002628	substrate binding site [chemical binding]; other site
362242002629	Zn binding site [ion binding]; other site
362242002630	Predicted transcriptional regulators [Transcription]; Region: COG1725
362242002631	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
362242002632	DNA-binding site [nucleotide binding]; DNA binding site
362242002633	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797
362242002634	PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618
362242002636	Protein of unknown function (DUF2510); Region: DUF2510; pfam10708
362242002637	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242002638	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242002639	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242002641	uncharacterized HhH-GPD family protein; Region: TIGR03252
362242002642	minor groove reading motif; other site
362242002643	helix-hairpin-helix signature motif; other site
362242002645	mannosyltransferase; Provisional; Region: pimE; PRK13375
362242002646	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488
362242002647	aromatic arch; other site
362242002648	DCoH dimer interaction site [polypeptide binding]; other site
362242002649	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
362242002650	DCoH tetramer interaction site [polypeptide binding]; other site
362242002651	substrate binding site [chemical binding]; other site
362242002652	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
362242002653	active site
362242002654	8-oxo-dGMP binding site [chemical binding]; other site
362242002655	nudix motif; other site
362242002656	metal binding site [ion binding]; metal-binding site
362242002657	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
362242002658	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
362242002659	G1 box; other site
362242002660	putative GEF interaction site [polypeptide binding]; other site
362242002661	GTP/Mg2+ binding site [chemical binding]; other site
362242002662	Switch I region; other site
362242002663	G2 box; other site
362242002664	G3 box; other site
362242002665	Switch II region; other site
362242002666	G4 box; other site
362242002667	G5 box; other site
362242002668	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
362242002669	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
362242002670	The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501
362242002671	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
362242002672	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242002673	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242002674	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242002675	Transposase, Mutator family; Region: Transposase_mut; pfam00872
362242002676	MULE transposase domain; Region: MULE; pfam10551
362242002677	N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D- glucopyranoside deacetylase; Region: mycothiol_MshB; TIGR03445
362242002678	PE family; Region: PE; pfam00934
362242002679	FO synthase; Reviewed; Region: fbiC; PRK09234
362242002680	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
362242002681	FeS/SAM binding site; other site
362242002682	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
362242002683	FeS/SAM binding site; other site
362242002684	PE family; Region: PE; pfam00934
362242002685	Cellulose binding domain; Region: CBM_2; pfam00553
362242002686	Cellulose binding domain; Region: CBM_2; pfam00553
362242002687	PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain.  Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543
362242002688	active site
362242002689	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
362242002690	2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli  is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930
362242002691	active site
362242002692	FMN binding site [chemical binding]; other site
362242002693	2,4-decadienoyl-CoA binding site; other site
362242002694	catalytic residue [active]
362242002695	4Fe-4S cluster binding site [ion binding]; other site
362242002696	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
362242002697	Predicted transcriptional regulators [Transcription]; Region: COG1695
362242002698	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
362242002699	Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400
362242002700	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
362242002701	4Fe-4S binding domain; Region: Fer4; pfam00037
362242002702	N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865
362242002703	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
362242002704	pyridoxal 5'-phosphate binding site [chemical binding]; other site
362242002705	homodimer interface [polypeptide binding]; other site
362242002706	catalytic residue [active]
362242002707	Transposase, Mutator family; Region: Transposase_mut; pfam00872
362242002708	MULE transposase domain; Region: MULE; pfam10551
362242002709	PE family; Region: PE; pfam00934
362242002710	PE-PPE domain; Region: PE-PPE; pfam08237
362242002711	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
362242002712	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
362242002713	3beta17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 3beta-17beta-HSD_like_SDR_c; cd05341
362242002714	homotetramer interface [polypeptide binding]; other site
362242002715	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
362242002716	NAD binding site [chemical binding]; other site
362242002717	homodimer interface [polypeptide binding]; other site
362242002718	active site
362242002719	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
362242002720	FAD binding domain; Region: FAD_binding_4; pfam01565
362242002721	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
362242002722	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
362242002723	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
362242002724	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
362242002725	Domain of unknown function (DUF427); Region: DUF427; cl00998
362242002726	Domain of unknown function (DUF427); Region: DUF427; pfam04248
362242002727	Ecdysteroid kinase; Region: EcKinase; cl17738
362242002728	Phosphotransferase enzyme family; Region: APH; pfam01636
362242002729	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
362242002730	CoA-transferase family III; Region: CoA_transf_3; pfam02515
362242002731	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
362242002732	Cytochrome P450; Region: p450; cl12078
362242002733	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
362242002734	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
362242002735	classical (c) SDRs; Region: SDR_c; cd05233
362242002736	NAD(P) binding site [chemical binding]; other site
362242002737	active site
362242002738	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
362242002739	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
362242002740	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
362242002741	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
362242002742	active site
362242002743	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819
362242002744	putative hydrophobic ligand binding site [chemical binding]; other site
362242002745	Transcriptional regulators [Transcription]; Region: FadR; COG2186
362242002746	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
362242002747	DNA-binding site [nucleotide binding]; DNA binding site
362242002748	FCD domain; Region: FCD; pfam07729
362242002749	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
362242002750	Permease; Region: Permease; pfam02405
362242002751	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
362242002752	Permease; Region: Permease; pfam02405
362242002753	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
362242002754	mce related protein; Region: MCE; pfam02470
362242002755	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
362242002756	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
362242002757	mce related protein; Region: MCE; pfam02470
362242002758	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
362242002759	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
362242002760	mce related protein; Region: MCE; pfam02470
362242002761	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
362242002762	mce related protein; Region: MCE; pfam02470
362242002763	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
362242002764	mce related protein; Region: MCE; pfam02470
362242002765	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
362242002766	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
362242002767	mce related protein; Region: MCE; pfam02470
362242002768	Predicted membrane protein [Function unknown]; Region: COG1511
362242002769	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
362242002770	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
362242002771	RNA polymerase factor sigma-70; Validated; Region: PRK08241
362242002772	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
362242002773	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
362242002774	DNA binding residues [nucleotide binding]
362242002775	SnoaL-like domain; Region: SnoaL_2; pfam12680
362242002776	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
362242002777	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
362242002778	Protein of unknown function (DUF2786); Region: DUF2786; pfam10979
362242002779	putative metallohydrolase, TIGR04338 family; Region: HEXXH_Rv0185
362242002780	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
362242002781	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
362242002782	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
362242002783	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
362242002789	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
362242002790	6-phosphogluconate dehydratase; Region: edd; TIGR01196
362242002791	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
362242002792	putative homodimer interface [polypeptide binding]; other site
362242002793	putative homotetramer interface [polypeptide binding]; other site
362242002794	putative allosteric switch controlling residues; other site
362242002795	putative metal binding site [ion binding]; other site
362242002796	putative homodimer-homodimer interface [polypeptide binding]; other site
362242002797	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
362242002798	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
362242002799	putative substrate translocation pore; other site
362242002800	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
362242002801	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431
362242002802	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
362242002803	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
362242002804	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
362242002805	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
362242002806	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
362242002807	active site
362242002808	Zn binding site [ion binding]; other site
362242002809	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
362242002810	non-specific DNA binding site [nucleotide binding]; other site
362242002811	salt bridge; other site
362242002812	sequence-specific DNA binding site [nucleotide binding]; other site
362242002813	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
362242002814	Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349
362242002815	Predicted integral membrane protein [Function unknown]; Region: COG0392
362242002816	MMPL family; Region: MMPL; pfam03176
362242002817	MMPL family; Region: MMPL; pfam03176
362242002818	LabA_like proteins; Region: LabA_like; cd06167
362242002819	putative metal binding site [ion binding]; other site
362242002820	tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121
362242002821	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819
362242002822	active site
362242002823	substrate-binding site [chemical binding]; other site
362242002824	metal-binding site [ion binding]
362242002825	GTP binding site [chemical binding]; other site
362242002826	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
362242002827	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
362242002828	substrate binding site [chemical binding]; other site
362242002829	oxyanion hole (OAH) forming residues; other site
362242002830	trimer interface [polypeptide binding]; other site
362242002831	Interferon-induced transmembrane protein; Region: CD225; pfam04505
362242002832	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242002833	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242002834	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242002835	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
362242002836	putative active site [active]
362242002837	putative catalytic site [active]
362242002838	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
362242002839	active site 2 [active]
362242002840	active site 1 [active]
362242002841	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
362242002842	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
362242002843	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
362242002844	active site
362242002845	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
362242002846	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cd00321
362242002847	Moco binding site; other site
362242002848	metal coordination site [ion binding]; other site
362242002849	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
362242002850	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
362242002851	enoyl-CoA hydratase; Provisional; Region: PRK08252
362242002852	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
362242002853	substrate binding site [chemical binding]; other site
362242002854	oxyanion hole (OAH) forming residues; other site
362242002855	trimer interface [polypeptide binding]; other site
362242002856	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
362242002857	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
362242002858	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
362242002859	acyl-activating enzyme (AAE) consensus motif; other site
362242002860	acyl-activating enzyme (AAE) consensus motif; other site
362242002861	AMP binding site [chemical binding]; other site
362242002862	active site
362242002863	CoA binding site [chemical binding]; other site
362242002864	acyl-CoA synthetase; Validated; Region: PRK05850
362242002865	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
362242002866	acyl-activating enzyme (AAE) consensus motif; other site
362242002867	active site
362242002868	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
362242002869	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
362242002870	enoyl-CoA hydratase; Provisional; Region: PRK06563
362242002871	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
362242002872	substrate binding site [chemical binding]; other site
362242002873	oxyanion hole (OAH) forming residues; other site
362242002874	trimer interface [polypeptide binding]; other site
362242002875	Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139
362242002876	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
362242002877	NAD binding site [chemical binding]; other site
362242002878	catalytic residues [active]
362242002879	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
362242002880	S-adenosylmethionine binding site [chemical binding]; other site
362242002881	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
362242002882	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
362242002883	Protein of unknown function (DUF3068); Region: DUF3068; pfam11271
362242002884	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
362242002885	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242002886	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242002887	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242002892	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242002893	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242002894	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242002895	Nitronate monooxygenase; Region: NMO; pfam03060
362242002896	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
362242002897	FMN binding site [chemical binding]; other site
362242002898	substrate binding site [chemical binding]; other site
362242002899	putative catalytic residue [active]
362242002901	PE family; Region: PE; pfam00934
362242002902	Transposase, Mutator family; Region: Transposase_mut; pfam00872
362242002903	MULE transposase domain; Region: MULE; pfam10551
362242002904	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
362242002905	active site
362242002906	catalytic site [active]
362242002907	substrate binding site [chemical binding]; other site
362242002908	Tellurite resistance protein TerB; Region: TerB; cl17311
362242002909	PE family; Region: PE; pfam00934
362242002910	Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530
362242002911	active site
362242002912	substrate binding pocket [chemical binding]; other site
362242002913	homodimer interaction site [polypeptide binding]; other site
362242002914	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
362242002915	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
362242002916	active site
362242002917	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
362242002918	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
362242002919	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
362242002920	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
362242002921	NAD(P) binding site [chemical binding]; other site
362242002922	catalytic residues [active]
362242002923	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
362242002924	PPE family; Region: PPE; pfam00823
362242002925	PE family; Region: PE; pfam00934
362242002926	Lipase maturation factor; Region: LMF1; pfam06762
362242002927	Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561
362242002928	Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009
362242002929	putative active site [active]
362242002930	catalytic site [active]
362242002931	putative metal binding site [ion binding]; other site
362242002932	Domain of unknown function (DUF3367); Region: DUF3367; pfam11847
362242002933	Protein of unknown function (DUF2613); Region: DUF2613; pfam11021
362242002934	Protein of unknown function (DUF2613); Region: DUF2613; pfam11021
362242002935	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
362242002936	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
362242002937	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
362242002938	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
362242002939	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915
362242002940	Cl- selectivity filter; other site
362242002941	Cl- binding residues [ion binding]; other site
362242002942	pore gating glutamate residue; other site
362242002943	dimer interface [polypeptide binding]; other site
362242002944	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
362242002945	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
362242002946	active site 2 [active]
362242002947	active site 1 [active]
362242002948	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261
362242002949	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
362242002950	NAD(P) binding site [chemical binding]; other site
362242002951	active site
362242002952	acetyl-CoA acetyltransferase; Provisional; Region: PRK09268
362242002953	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
362242002954	dimer interface [polypeptide binding]; other site
362242002955	active site
362242002956	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
362242002957	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
362242002958	Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153
362242002959	FAD binding site [chemical binding]; other site
362242002960	substrate binding site [chemical binding]; other site
362242002961	catalytic residues [active]
362242002962	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
362242002963	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
362242002964	fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386
362242002965	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
362242002966	catalytic loop [active]
362242002967	iron binding site [ion binding]; other site
362242002968	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803
362242002969	L-aspartate oxidase; Provisional; Region: PRK06175
362242002970	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
362242002971	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242002972	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242002973	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242002974	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
362242002975	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
362242002976	tetramer interface [polypeptide binding]; other site
362242002977	active site
362242002978	Mg2+/Mn2+ binding site [ion binding]; other site
362242002979	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
362242002980	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
362242002981	putative dimer interface [polypeptide binding]; other site
362242002982	Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529
362242002983	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
362242002984	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
362242002985	putative active site [active]
362242002986	Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784
362242002987	active site
362242002988	bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239
362242002989	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
362242002990	active site
362242002991	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
362242002992	DNA binding site [nucleotide binding]
362242002993	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
362242002994	Coenzyme A binding pocket [chemical binding]; other site
362242002995	Allophanate hydrolase subunit 2; Region: AHS2; cl00865
362242002996	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
362242002997	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
362242002998	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
362242002999	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
362242003000	intersubunit interface [polypeptide binding]; other site
362242003001	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
362242003002	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
362242003003	LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865
362242003004	nucleotide binding site [chemical binding]; other site
362242003005	acyl-CoA synthetase; Validated; Region: PRK07788
362242003006	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
362242003007	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
362242003008	active site
362242003009	CoA binding site [chemical binding]; other site
362242003010	AMP binding site [chemical binding]; other site
362242003011	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
362242003012	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
362242003013	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
362242003014	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
362242003015	active site
362242003016	Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152
362242003017	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
362242003018	FAD binding site [chemical binding]; other site
362242003019	substrate binding site [chemical binding]; other site
362242003020	catalytic base [active]
362242003021	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
362242003022	Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_11; cd12175
362242003023	putative ligand binding site [chemical binding]; other site
362242003024	putative NAD binding site [chemical binding]; other site
362242003025	catalytic site [active]
362242003026	Esterase/lipase [General function prediction only]; Region: COG1647
362242003027	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
362242003028	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
362242003029	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
362242003030	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
362242003031	Zn binding site [ion binding]; other site
362242003032	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
362242003033	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472
362242003034	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
362242003035	PPE family; Region: PPE; pfam00823
362242003036	type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922
362242003037	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
362242003038	Walker A motif; other site
362242003039	ATP binding site [chemical binding]; other site
362242003040	Walker B motif; other site
362242003041	arginine finger; other site
362242003042	Protein of unknown function (DUF690); Region: DUF690; pfam05108
362242003043	type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924
362242003044	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
362242003045	type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925
362242003046	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
362242003047	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
362242003048	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
362242003049	PPE family; Region: PPE; pfam00823
362242003050	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842
362242003051	EspG family; Region: ESX-1_EspG; pfam14011
362242003052	WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489
362242003053	WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489
362242003054	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
362242003055	type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921
362242003056	active site
362242003057	catalytic residues [active]
362242003058	type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923
362242003059	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
362242003060	Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752
362242003061	Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106
362242003062	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
362242003063	S-adenosylmethionine binding site [chemical binding]; other site
362242003064	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
362242003065	Sulfatase; Region: Sulfatase; pfam00884
362242003066	Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145
362242003067	putative FMN binding site [chemical binding]; other site
362242003068	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
362242003069	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
362242003070	active site
362242003071	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786
362242003072	SnoaL-like domain; Region: SnoaL_4; pfam13577
362242003073	SnoaL-like domain; Region: SnoaL_3; pfam13474
362242003074	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
362242003075	nucleotide binding site [chemical binding]; other site
362242003076	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
362242003077	acyl-coenzyme A oxidase; Region: PLN02636
362242003078	active site
362242003079	CCC1-related family of proteins; Region: CCC1_like; cl00278
362242003080	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242003081	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242003082	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242003083	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
362242003084	ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864
362242003085	Walker A/P-loop; other site
362242003086	ATP binding site [chemical binding]; other site
362242003087	Q-loop/lid; other site
362242003088	ABC transporter signature motif; other site
362242003089	Walker B; other site
362242003090	D-loop; other site
362242003091	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
362242003092	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
362242003093	Transcriptional regulators [Transcription]; Region: MarR; COG1846
362242003094	MarR family; Region: MarR; pfam01047
362242003095	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13644
362242003096	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
362242003097	Walker A/P-loop; other site
362242003098	ATP binding site [chemical binding]; other site
362242003099	Q-loop/lid; other site
362242003100	ABC transporter signature motif; other site
362242003101	Walker B; other site
362242003102	D-loop; other site
362242003103	H-loop/switch region; other site
362242003104	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
362242003105	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
362242003106	Walker A/P-loop; other site
362242003107	ATP binding site [chemical binding]; other site
362242003108	Q-loop/lid; other site
362242003109	ABC transporter signature motif; other site
362242003110	Walker B; other site
362242003111	D-loop; other site
362242003112	H-loop/switch region; other site
362242003113	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
362242003114	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
362242003115	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
362242003116	putative DNA binding site [nucleotide binding]; other site
362242003117	putative Zn2+ binding site [ion binding]; other site
362242003118	AsnC family; Region: AsnC_trans_reg; pfam01037
362242003119	N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834
362242003120	Amidinotransferase; Region: Amidinotransf; pfam02274
362242003121	ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073
362242003122	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
362242003123	inhibitor-cofactor binding pocket; inhibition site
362242003124	pyridoxal 5'-phosphate binding site [chemical binding]; other site
362242003125	catalytic residue [active]
362242003126	amino acid transporter; Region: 2A0306; TIGR00909
362242003127	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
362242003128	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
362242003129	Ligand Binding Site [chemical binding]; other site
362242003130	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
362242003131	Ligand Binding Site [chemical binding]; other site
362242003132	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
362242003133	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
362242003134	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
362242003135	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
362242003136	dimer interface [polypeptide binding]; other site
362242003137	conserved gate region; other site
362242003138	putative PBP binding loops; other site
362242003139	ABC-ATPase subunit interface; other site
362242003140	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
362242003141	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
362242003142	dimer interface [polypeptide binding]; other site
362242003143	conserved gate region; other site
362242003144	putative PBP binding loops; other site
362242003145	ABC-ATPase subunit interface; other site
362242003146	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
362242003147	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
362242003148	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
362242003149	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
362242003150	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
362242003151	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
362242003152	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
362242003153	motif II; other site
362242003154	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
362242003155	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242
362242003156	putative dimer interface [polypeptide binding]; other site
362242003157	ligand binding site [chemical binding]; other site
362242003158	Zn binding site [ion binding]; other site
362242003159	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242003160	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242003161	Transposase, Mutator family; Region: Transposase_mut; pfam00872
362242003162	MULE transposase domain; Region: MULE; pfam10551
362242003163	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
362242003164	active site
362242003165	probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560
362242003166	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
362242003167	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
362242003168	(p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691
362242003169	Transposase, Mutator family; Region: Transposase_mut; pfam00872
362242003170	MULE transposase domain; Region: MULE; pfam10551
362242003171	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
362242003172	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
362242003173	motif II; other site
362242003174	Ion channel; Region: Ion_trans_2; pfam07885
362242003175	Domain of unknown function (DUF202); Region: DUF202; pfam02656
362242003176	Predicted membrane protein [Function unknown]; Region: COG2149
362242003177	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
362242003178	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242003179	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242003180	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
362242003181	S-adenosylmethionine binding site [chemical binding]; other site
362242003182	Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231
362242003183	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
362242003184	hydroxyglutarate oxidase; Provisional; Region: PRK11728
362242003185	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
362242003186	Cytochrome P450; Region: p450; cl12078
362242003187	SAM dependent carboxyl methyltransferase; Region: Methyltransf_7; cl04109
362242003188	short chain dehydrogenase; Provisional; Region: PRK05854
362242003189	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
362242003190	putative NAD(P) binding site [chemical binding]; other site
362242003191	active site
362242003192	Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815
362242003193	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
362242003194	putative active site [active]
362242003195	catalytic triad [active]
362242003196	putative dimer interface [polypeptide binding]; other site
362242003197	Short C-terminal domain; Region: SHOCT; pfam09851
362242003198	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
362242003199	S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451
362242003200	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
362242003201	NAD binding site [chemical binding]; other site
362242003202	catalytic Zn binding site [ion binding]; other site
362242003203	substrate binding site [chemical binding]; other site
362242003204	structural Zn binding site [ion binding]; other site
362242003205	Methyltransferase domain; Region: Methyltransf_31; pfam13847
362242003206	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
362242003207	S-adenosylmethionine binding site [chemical binding]; other site
362242003208	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
362242003209	Beta-lactamase; Region: Beta-lactamase; pfam00144
362242003210	Protein of unknown function (DUF3145); Region: DUF3145; pfam11343
362242003211	diacylglycerol kinase; Reviewed; Region: PRK11914
362242003212	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
362242003213	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
362242003214	FAD binding domain; Region: FAD_binding_4; pfam01565
362242003215	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
362242003216	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
362242003217	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
362242003218	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
362242003219	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
362242003220	putative active site [active]
362242003221	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
362242003222	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
362242003223	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
362242003224	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910
362242003225	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
362242003226	dimer interface [polypeptide binding]; other site
362242003227	active site
362242003228	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910
362242003229	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
362242003230	dimer interface [polypeptide binding]; other site
362242003231	active site
362242003232	acyl carrier protein; Provisional; Region: acpP; PRK00982
362242003233	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
362242003234	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
362242003235	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
362242003236	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
362242003237	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
362242003238	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
362242003239	dimer interface [polypeptide binding]; other site
362242003240	TPP-binding site [chemical binding]; other site
362242003241	Protein of unknown function (DUF3052); Region: DUF3052; pfam11253
362242003242	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
362242003243	Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018
362242003244	dimer interface [polypeptide binding]; other site
362242003245	catalytic triad [active]
362242003246	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
362242003247	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
362242003248	Cation efflux family; Region: Cation_efflux; cl00316
362242003249	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
362242003250	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472
362242003251	cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209
362242003252	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
362242003253	Low molecular weight phosphatase family; Region: LMWPc; cd00115
362242003254	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
362242003255	active site
362242003256	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
362242003257	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
362242003258	motif II; other site
362242003259	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
362242003260	hypothetical protein; Provisional; Region: PRK07908
362242003261	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
362242003262	pyridoxal 5'-phosphate binding site [chemical binding]; other site
362242003263	homodimer interface [polypeptide binding]; other site
362242003264	catalytic residue [active]
362242003265	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
362242003266	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
362242003267	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
362242003268	Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
362242003269	Putative zinc ribbon domain; Region: DUF164; pfam02591
362242003270	bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238
362242003271	RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
362242003272	RNA/DNA hybrid binding site [nucleotide binding]; other site
362242003273	active site
362242003274	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
362242003275	catalytic core [active]
362242003277	CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374
362242003278	putative active site; other site
362242003279	putative metal binding residues [ion binding]; other site
362242003280	signature motif; other site
362242003281	putative triphosphate binding site [ion binding]; other site
362242003282	CHAD domain; Region: CHAD; pfam05235
362242003283	The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880
362242003284	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
362242003285	oligomerization interface [polypeptide binding]; other site
362242003286	active site
362242003287	metal binding site [ion binding]; metal-binding site
362242003288	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
362242003289	TAP-like protein; Region: Abhydrolase_4; pfam08386
362242003290	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
362242003291	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
362242003292	D-pathway; other site
362242003293	Putative ubiquinol binding site [chemical binding]; other site
362242003294	Low-spin heme (heme b) binding site [chemical binding]; other site
362242003295	Putative water exit pathway; other site
362242003296	Binuclear center (heme o3/CuB) [ion binding]; other site
362242003297	K-pathway; other site
362242003298	Putative proton exit pathway; other site
362242003299	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
362242003300	TAP-like protein; Region: Abhydrolase_4; pfam08386
362242003301	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
362242003302	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
362242003303	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
362242003304	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109
362242003305	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
362242003306	metal binding triad; other site
362242003307	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
362242003308	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
362242003309	metal binding triad; other site
362242003310	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
362242003311	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
362242003312	PE family; Region: PE; pfam00934
362242003315	glutamine synthetase, type I; Region: GlnA; TIGR00653
362242003316	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
362242003317	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
362242003318	RDD family; Region: RDD; pfam06271
362242003319	Domain of unknown function (DUF4191); Region: DUF4191; pfam13829
362242003320	lipoyl synthase; Provisional; Region: PRK05481
362242003321	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
362242003322	FeS/SAM binding site; other site
362242003323	lipoate-protein ligase B; Provisional; Region: PRK14345
362242003324	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
362242003325	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
362242003326	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
362242003327	Walker A/P-loop; other site
362242003328	ATP binding site [chemical binding]; other site
362242003329	Q-loop/lid; other site
362242003330	ABC transporter signature motif; other site
362242003331	Walker B; other site
362242003332	D-loop; other site
362242003333	H-loop/switch region; other site
362242003334	Protein of unknown function (DUF1622); Region: DUF1622; pfam07784
362242003335	acetolactate synthase; Reviewed; Region: PRK08322
362242003336	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
362242003337	PYR/PP interface [polypeptide binding]; other site
362242003338	dimer interface [polypeptide binding]; other site
362242003339	TPP binding site [chemical binding]; other site
362242003340	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
362242003341	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
362242003342	TPP-binding site [chemical binding]; other site
362242003343	Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480
362242003344	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
362242003345	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
362242003346	Putative zinc-finger; Region: zf-HC2; pfam13490
362242003347	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
362242003348	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
362242003349	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
362242003350	DNA binding residues [nucleotide binding]
362242003351	PA26 p53-induced protein (sestrin); Region: PA26; pfam04636
362242003352	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
362242003353	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
362242003354	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
362242003355	Transposase, Mutator family; Region: Transposase_mut; pfam00872
362242003356	MULE transposase domain; Region: MULE; pfam10551
362242003357	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242003358	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242003359	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242003361	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
362242003362	adenosine deaminase; Provisional; Region: PRK09358
362242003363	active site
362242003364	thymidine phosphorylase; Reviewed; Region: deoA; PRK05820
362242003365	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
362242003366	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
362242003367	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941
362242003368	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
362242003369	active site
362242003370	catalytic motif [active]
362242003371	Zn binding site [ion binding]; other site
362242003372	Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501
362242003373	putative Iron-sulfur protein interface [polypeptide binding]; other site
362242003374	putative proximal heme binding site [chemical binding]; other site
362242003375	putative SdhD-like interface [polypeptide binding]; other site
362242003376	putative distal heme binding site [chemical binding]; other site
362242003377	Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500
362242003378	putative Iron-sulfur protein interface [polypeptide binding]; other site
362242003379	putative proximal heme binding site [chemical binding]; other site
362242003380	putative SdhC-like subunit interface [polypeptide binding]; other site
362242003381	putative distal heme binding site [chemical binding]; other site
362242003382	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205
362242003383	L-aspartate oxidase; Provisional; Region: PRK06175
362242003384	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
362242003385	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
362242003386	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
362242003387	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242003388	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242003389	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
362242003390	active site
362242003391	metal binding site A [ion binding]; metal-binding site
362242003392	DNA binding site [nucleotide binding]
362242003393	putative catalytic site [active]
362242003394	putative phosphate binding site [ion binding]; other site
362242003395	putative AP binding site [nucleotide binding]; other site
362242003396	putative metal binding site B [ion binding]; other site
362242003397	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
362242003398	active site
362242003399	catalytic residues [active]
362242003400	metal binding site [ion binding]; metal-binding site
362242003401	Protein of unknown function (DUF3263); Region: DUF3263; pfam11662
362242003402	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
362242003403	Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032
362242003404	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
362242003405	E-class dimer interface [polypeptide binding]; other site
362242003406	P-class dimer interface [polypeptide binding]; other site
362242003407	active site
362242003408	Cu2+ binding site [ion binding]; other site
362242003409	Zn2+ binding site [ion binding]; other site
362242003410	carboxylate-amine ligase; Provisional; Region: PRK13517
362242003411	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
362242003412	Transcriptional regulators [Transcription]; Region: FadR; COG2186
362242003413	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
362242003414	DNA-binding site [nucleotide binding]; DNA binding site
362242003415	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
362242003416	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
362242003417	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
362242003418	putative substrate translocation pore; other site
362242003419	Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802
362242003420	AAA family ATPase, CDC48 subfamily; Region: CDC48; TIGR01243
362242003421	Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359
362242003422	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
362242003423	Walker A motif; other site
362242003424	ATP binding site [chemical binding]; other site
362242003425	Walker B motif; other site
362242003426	arginine finger; other site
362242003427	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
362242003428	Walker A motif; other site
362242003429	ATP binding site [chemical binding]; other site
362242003430	Walker B motif; other site
362242003431	arginine finger; other site
362242003432	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
362242003433	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
362242003434	phosphatidylserine decarboxylase; Provisional; Region: PRK05305
362242003436	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242003437	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242003438	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242003439	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
362242003440	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
362242003441	dimer interface [polypeptide binding]; other site
362242003442	putative functional site; other site
362242003443	putative MPT binding site; other site
362242003444	short chain dehydrogenase; Provisional; Region: PRK06197
362242003445	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
362242003446	putative NAD(P) binding site [chemical binding]; other site
362242003447	active site
362242003448	Cupin domain; Region: Cupin_2; pfam07883
362242003449	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
362242003450	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
362242003451	ring oligomerisation interface [polypeptide binding]; other site
362242003452	ATP/Mg binding site [chemical binding]; other site
362242003453	stacking interactions; other site
362242003454	hinge regions; other site
362242003455	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
362242003456	PPE family; Region: PPE; pfam00823
362242003457	N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653
362242003458	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
362242003459	active site
362242003460	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
362242003461	Protein of unknown function (DUF664); Region: DUF664; pfam04978
362242003462	DinB superfamily; Region: DinB_2; pfam12867
362242003463	Anti-sigma-K factor rskA; Region: RskA; pfam10099
362242003464	RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646
362242003465	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
362242003466	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
362242003467	DNA binding residues [nucleotide binding]
362242003468	Protein of unknown function (DUF1295); Region: DUF1295; cl17837
362242003469	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
362242003470	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
362242003471	S-adenosylmethionine binding site [chemical binding]; other site
362242003472	Protein of unknown function (DUF1365); Region: DUF1365; cl17838
362242003473	Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907
362242003474	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
362242003475	Transposase, Mutator family; Region: Transposase_mut; pfam00872
362242003476	MULE transposase domain; Region: MULE; pfam10551
362242003477	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242003478	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242003479	Transposase, Mutator family; Region: Transposase_mut; pfam00872
362242003480	MULE transposase domain; Region: MULE; pfam10551
362242003481	Protein of unknown function (DUF2782); Region: DUF2782; pfam11191
362242003482	enoyl-CoA hydratase; Provisional; Region: PRK12478
362242003483	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
362242003484	substrate binding site [chemical binding]; other site
362242003485	oxyanion hole (OAH) forming residues; other site
362242003486	trimer interface [polypeptide binding]; other site
362242003487	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
362242003488	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
362242003489	NAD(P) binding site [chemical binding]; other site
362242003490	catalytic residues [active]
362242003491	Protein of unknown function (DUF779); Region: DUF779; pfam05610
362242003492	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242003493	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242003494	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242003495	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
362242003496	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
362242003497	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062
362242003498	phosphopeptide binding site; other site
362242003499	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
362242003500	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
362242003501	phosphopeptide binding site; other site
362242003502	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
362242003503	Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213
362242003504	Walker A/P-loop; other site
362242003505	ATP binding site [chemical binding]; other site
362242003506	Q-loop/lid; other site
362242003507	ABC transporter signature motif; other site
362242003508	Walker B; other site
362242003509	D-loop; other site
362242003510	H-loop/switch region; other site
362242003511	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
362242003512	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193
362242003513	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
362242003514	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
362242003515	homodimer interface [polypeptide binding]; other site
362242003516	NADP binding site [chemical binding]; other site
362242003517	substrate binding site [chemical binding]; other site
362242003518	Protein of unknown function (DUF3017); Region: DUF3017; pfam11222
362242003519	Protein of unknown function (DUF732); Region: DUF732; pfam05305
362242003520	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
362242003521	FAD binding domain; Region: FAD_binding_4; pfam01565
362242003522	Berberine and berberine like; Region: BBE; pfam08031
362242003523	acyl-CoA synthetase; Validated; Region: PRK05850
362242003524	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
362242003525	acyl-activating enzyme (AAE) consensus motif; other site
362242003526	active site
362242003527	TcdA/TcdB pore forming domain; Region: TcdA_TcdB_pore; pfam12920
362242003528	Methyltransferase domain; Region: Methyltransf_23; pfam13489
362242003529	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
362242003530	S-adenosylmethionine binding site [chemical binding]; other site
362242003531	Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021
362242003532	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
362242003533	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812
362242003534	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
362242003535	homodimer interface [polypeptide binding]; other site
362242003536	substrate-cofactor binding pocket; other site
362242003537	pyridoxal 5'-phosphate binding site [chemical binding]; other site
362242003538	catalytic residue [active]
362242003539	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
362242003540	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
362242003541	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
362242003542	active site
362242003543	HIGH motif; other site
362242003544	dimer interface [polypeptide binding]; other site
362242003545	KMSKS motif; other site
362242003546	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
362242003547	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
362242003548	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
362242003549	active site
362242003550	dimer interface [polypeptide binding]; other site
362242003551	MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879
362242003552	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
362242003553	putative substrate translocation pore; other site
362242003554	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
362242003555	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
362242003556	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
362242003557	DNA binding residues [nucleotide binding]
362242003558	Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699
362242003559	marine proteobacterial sortase target protein; Region: marine_srt_targ; TIGR03788
362242003560	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
362242003561	metal ion-dependent adhesion site (MIDAS); other site
362242003563	PE family; Region: PE; pfam00934
362242003566	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242003567	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242003568	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242003569	WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930
362242003570	Proteins of 100 residues with WXG; Region: WXG100; pfam06013
362242003571	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007
362242003572	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
362242003573	Zn2+ binding site [ion binding]; other site
362242003574	Mg2+ binding site [ion binding]; other site
362242003575	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
362242003576	DNA primase; Validated; Region: dnaG; PRK05667
362242003577	CHC2 zinc finger; Region: zf-CHC2; cl17510
362242003578	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
362242003579	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
362242003580	active site
362242003581	metal binding site [ion binding]; metal-binding site
362242003582	interdomain interaction site; other site
362242003583	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
362242003584	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766
362242003585	Domain of unknown function (DUF4395); Region: DUF4395; pfam14340
362242003586	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
362242003587	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
362242003588	catalytic residues [active]
362242003589	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
362242003590	trimer interface [polypeptide binding]; other site
362242003591	active site
362242003592	substrate binding site [chemical binding]; other site
362242003593	CoA binding site [chemical binding]; other site
362242003594	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
362242003595	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
362242003596	dimer interface [polypeptide binding]; other site
362242003597	pyridoxal 5'-phosphate binding site [chemical binding]; other site
362242003598	catalytic residue [active]
362242003599	malate dehydrogenase; Provisional; Region: PRK13529
362242003600	Malic enzyme, N-terminal domain; Region: malic; pfam00390
362242003601	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
362242003602	NAD(P) binding pocket [chemical binding]; other site
362242003603	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
362242003604	putative substrate translocation pore; other site
362242003605	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242003606	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242003607	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242003608	Transposase, Mutator family; Region: Transposase_mut; pfam00872
362242003609	MULE transposase domain; Region: MULE; pfam10551
362242003610	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
362242003611	dimerization interface [polypeptide binding]; other site
362242003612	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
362242003613	cyclase homology domain; Region: CHD; cd07302
362242003614	nucleotidyl binding site; other site
362242003615	metal binding site [ion binding]; metal-binding site
362242003616	dimer interface [polypeptide binding]; other site
362242003617	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
362242003618	formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591
362242003619	[4Fe-4S] binding site [ion binding]; other site
362242003620	molybdopterin cofactor binding site; other site
362242003621	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
362242003622	molybdopterin cofactor binding site; other site
362242003623	sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931
362242003624	Flavodoxin; Region: Flavodoxin_1; pfam00258
362242003625	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
362242003626	FAD binding pocket [chemical binding]; other site
362242003627	FAD binding motif [chemical binding]; other site
362242003628	catalytic residues [active]
362242003629	NAD binding pocket [chemical binding]; other site
362242003630	phosphate binding motif [ion binding]; other site
362242003631	beta-alpha-beta structure motif; other site
362242003632	LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041
362242003633	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
362242003634	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
362242003635	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
362242003636	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
362242003637	catalytic residues [active]
362242003638	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
362242003639	catalytic residues [active]
362242003640	enoyl-CoA hydratase; Provisional; Region: PRK05864
362242003641	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
362242003642	substrate binding site [chemical binding]; other site
362242003643	oxyanion hole (OAH) forming residues; other site
362242003644	trimer interface [polypeptide binding]; other site
362242003645	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
362242003646	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
362242003647	Walker A/P-loop; other site
362242003648	ATP binding site [chemical binding]; other site
362242003649	Q-loop/lid; other site
362242003650	ABC transporter signature motif; other site
362242003651	Walker B; other site
362242003652	D-loop; other site
362242003653	H-loop/switch region; other site
362242003654	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
362242003655	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
362242003656	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
362242003657	aconitate hydratase; Validated; Region: PRK09277
362242003658	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
362242003659	substrate binding site [chemical binding]; other site
362242003660	ligand binding site [chemical binding]; other site
362242003661	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
362242003662	substrate binding site [chemical binding]; other site
362242003663	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
362242003664	NlpC/P60 family; Region: NLPC_P60; pfam00877
362242003665	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
362242003666	NlpC/P60 family; Region: NLPC_P60; pfam00877
362242003667	MoxR-like ATPases [General function prediction only]; Region: COG0714
362242003668	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
362242003669	Walker A motif; other site
362242003670	ATP binding site [chemical binding]; other site
362242003671	Walker B motif; other site
362242003672	arginine finger; other site
362242003673	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
362242003674	Protein of unknown function DUF58; Region: DUF58; pfam01882
362242003675	hypothetical protein; Provisional; Region: PRK13685
362242003676	Aerotolerance regulator N-terminal; Region: BatA; pfam07584
362242003677	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
362242003678	metal ion-dependent adhesion site (MIDAS); other site
362242003679	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
362242003680	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
362242003681	NAD(P) binding site [chemical binding]; other site
362242003682	homotetramer interface [polypeptide binding]; other site
362242003683	homodimer interface [polypeptide binding]; other site
362242003684	active site
362242003685	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889
362242003686	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
362242003687	NAD binding site [chemical binding]; other site
362242003688	homotetramer interface [polypeptide binding]; other site
362242003689	homodimer interface [polypeptide binding]; other site
362242003690	substrate binding site [chemical binding]; other site
362242003691	active site
362242003692	ferrochelatase; Reviewed; Region: hemH; PRK00035
362242003693	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
362242003694	C-terminal domain interface [polypeptide binding]; other site
362242003695	active site
362242003696	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
362242003697	active site
362242003698	N-terminal domain interface [polypeptide binding]; other site
362242003699	Transposase, Mutator family; Region: Transposase_mut; pfam00872
362242003700	MULE transposase domain; Region: MULE; pfam10551
362242003701	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
362242003702	DoxX-like family; Region: DoxX_2; pfam13564
362242003703	deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026
362242003704	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
362242003705	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
362242003706	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
362242003707	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
362242003708	active site
362242003709	phosphorylation site [posttranslational modification]
362242003710	intermolecular recognition site; other site
362242003711	dimerization interface [polypeptide binding]; other site
362242003712	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
362242003713	DNA binding site [nucleotide binding]
362242003714	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
362242003715	His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388
362242003716	dimer interface [polypeptide binding]; other site
362242003717	phosphorylation site [posttranslational modification]
362242003718	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
362242003719	ATP binding site [chemical binding]; other site
362242003720	Mg2+ binding site [ion binding]; other site
362242003721	G-X-G motif; other site
362242003722	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
362242003723	Uncharacterized conserved protein [Function unknown]; Region: COG0398
362242003724	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
362242003725	methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642
362242003726	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677
362242003727	heterodimer interface [polypeptide binding]; other site
362242003728	substrate interaction site [chemical binding]; other site
362242003729	Methylmalonyl-CoA mutase, C-terminal domain/subunit (cobalamin-binding) [Lipid metabolism]; Region: Sbm; COG2185
362242003730	methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
362242003731	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679
362242003732	active site
362242003733	substrate binding site [chemical binding]; other site
362242003734	coenzyme B12 binding site [chemical binding]; other site
362242003735	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
362242003736	B12 binding site [chemical binding]; other site
362242003737	cobalt ligand [ion binding]; other site
362242003738	membrane ATPase/protein kinase; Provisional; Region: PRK09435
362242003739	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
362242003740	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
362242003741	Walker A; other site
362242003742	Dodecin; Region: Dodecin; pfam07311
362242003743	UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721
362242003744	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
362242003745	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
362242003746	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
362242003747	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
362242003748	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
362242003749	NAD(P) binding site [chemical binding]; other site
362242003750	active site
362242003751	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242003752	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242003753	Transposase, Mutator family; Region: Transposase_mut; pfam00872
362242003754	MULE transposase domain; Region: MULE; pfam10551
362242003755	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
362242003756	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
362242003757	Probable Catalytic site; other site
362242003758	metal-binding site
362242003759	transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283
362242003760	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
362242003761	active site
362242003762	Protein of unknown function (DUF2910); Region: DUF2910; pfam11139
362242003763	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242003764	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242003765	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242003766	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
362242003767	active site
362242003768	TDP-binding site; other site
362242003769	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
362242003770	Condensation domain; Region: Condensation; pfam00668
362242003771	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039
362242003772	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
362242003773	HIGH motif; other site
362242003774	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
362242003775	active site
362242003776	KMSKS motif; other site
362242003777	Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961
362242003778	tRNA binding surface [nucleotide binding]; other site
362242003779	anticodon binding site; other site
362242003780	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
362242003781	S-adenosylmethionine binding site [chemical binding]; other site
362242003782	DNA polymerase IV; Provisional; Region: PRK03348
362242003783	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
362242003784	active site
362242003785	DNA binding site [nucleotide binding]
362242003786	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
362242003787	active site
362242003788	homodimer interface [polypeptide binding]; other site
362242003789	homotetramer interface [polypeptide binding]; other site
362242003790	lipoprotein signal peptidase; Provisional; Region: PRK14764
362242003791	pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
362242003792	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
362242003793	active site
362242003794	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
362242003795	S-adenosylmethionine binding site [chemical binding]; other site
362242003796	Uncharacterized protein conserved in bacteria, putative lipoprotein [Function unknown]; Region: LprI; COG4461
362242003797	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
362242003798	Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864
362242003799	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
362242003800	apolar tunnel; other site
362242003801	heme binding site [chemical binding]; other site
362242003802	dimerization interface [polypeptide binding]; other site
362242003803	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
362242003804	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
362242003805	NAD(P) binding site [chemical binding]; other site
362242003806	active site
362242003807	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
362242003808	hydrophobic ligand binding site; other site
362242003809	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
362242003810	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
362242003811	active site
362242003812	PHP Thumb interface [polypeptide binding]; other site
362242003813	metal binding site [ion binding]; metal-binding site
362242003814	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
362242003815	generic binding surface II; other site
362242003816	generic binding surface I; other site
362242003817	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
362242003818	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
362242003819	acyl-activating enzyme (AAE) consensus motif; other site
362242003820	putative AMP binding site [chemical binding]; other site
362242003821	putative active site [active]
362242003822	putative CoA binding site [chemical binding]; other site
362242003823	glycerol-3-phosphate acyltransferase; Reviewed; Region: PRK11915
362242003824	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993
362242003825	putative acyl-acceptor binding pocket; other site
362242003826	Domain of unknown function (DUF385); Region: DUF385; pfam04075
362242003827	threonine dehydratase; Validated; Region: PRK08639
362242003828	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
362242003829	tetramer interface [polypeptide binding]; other site
362242003830	pyridoxal 5'-phosphate binding site [chemical binding]; other site
362242003831	catalytic residue [active]
362242003832	C-terminal regulatory domain of Threonine dehydratase; Region: Thr_dehydrat_C; pfam00585
362242003833	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900
362242003834	transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481
362242003835	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
362242003836	DNA-binding site [nucleotide binding]; DNA binding site
362242003837	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
362242003838	pyridoxal 5'-phosphate binding site [chemical binding]; other site
362242003839	homodimer interface [polypeptide binding]; other site
362242003840	catalytic residue [active]
362242003841	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
362242003842	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
362242003843	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
362242003844	catalytic site [active]
362242003845	active site
362242003846	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
362242003847	malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401
362242003848	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
362242003849	active site
362242003850	catalytic site [active]
362242003851	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
362242003852	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
362242003853	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
362242003854	active site
362242003855	catalytic site [active]
362242003856	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
362242003857	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
362242003858	NlpC/P60 family; Region: NLPC_P60; pfam00877
362242003859	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964
362242003860	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
362242003861	inhibitor-cofactor binding pocket; inhibition site
362242003862	pyridoxal 5'-phosphate binding site [chemical binding]; other site
362242003863	catalytic residue [active]
362242003864	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
362242003865	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
362242003866	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
362242003867	catalytic residue [active]
362242003868	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
362242003869	2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563
362242003870	biotin synthase; Validated; Region: PRK06256
362242003871	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
362242003872	FeS/SAM binding site; other site
362242003873	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
362242003874	Protein of unknown function (DUF2567); Region: DUF2567; pfam10821
362242003875	Secretory lipase; Region: LIP; pfam03583
362242003876	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
362242003877	nudix motif; other site
362242003878	Uncharacterized conserved protein [General function prediction only]; Region: COG4111
362242003879	quinolinate synthetase; Provisional; Region: PRK09375
362242003880	L-aspartate oxidase; Provisional; Region: PRK07804
362242003881	L-aspartate oxidase; Provisional; Region: PRK06175
362242003882	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
362242003883	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896
362242003884	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
362242003885	dimerization interface [polypeptide binding]; other site
362242003886	active site
362242003887	Domain of unknown function (DUF385); Region: DUF385; cl04387
362242003888	Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815
362242003889	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
362242003890	NAD binding site [chemical binding]; other site
362242003891	dimerization interface [polypeptide binding]; other site
362242003892	product binding site; other site
362242003893	substrate binding site [chemical binding]; other site
362242003894	zinc binding site [ion binding]; other site
362242003895	catalytic residues [active]
362242003896	histidinol-phosphate aminotransferase; Provisional; Region: PRK03317
362242003897	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
362242003898	pyridoxal 5'-phosphate binding site [chemical binding]; other site
362242003899	homodimer interface [polypeptide binding]; other site
362242003900	catalytic residue [active]
362242003901	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
362242003902	4-fold oligomerization interface [polypeptide binding]; other site
362242003903	putative active site pocket [active]
362242003904	metal binding residues [ion binding]; metal-binding site
362242003905	3-fold/trimer interface [polypeptide binding]; other site
362242003906	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
362242003907	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
362242003908	putative active site [active]
362242003909	oxyanion strand; other site
362242003910	catalytic triad [active]
362242003911	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
362242003912	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
362242003913	catalytic residues [active]
362242003914	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
362242003915	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
362242003916	active site
362242003917	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
362242003918	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
362242003919	substrate binding site [chemical binding]; other site
362242003920	glutamase interaction surface [polypeptide binding]; other site
362242003921	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
362242003922	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250
362242003923	active site
362242003924	Zn binding site [ion binding]; other site
362242003925	Transposase, Mutator family; Region: Transposase_mut; pfam00872
362242003926	MULE transposase domain; Region: MULE; pfam10551
362242003927	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242003928	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242003929	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
362242003930	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
362242003931	catalytic triad [active]
362242003932	anthranilate synthase component I; Provisional; Region: PRK13571
362242003933	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
362242003934	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
362242003935	Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534
362242003936	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
362242003937	active site
362242003938	ribulose/triose binding site [chemical binding]; other site
362242003939	phosphate binding site [ion binding]; other site
362242003940	substrate (anthranilate) binding pocket [chemical binding]; other site
362242003941	product (indole) binding pocket [chemical binding]; other site
362242003942	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
362242003943	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
362242003944	pyridoxal 5'-phosphate binding site [chemical binding]; other site
362242003945	catalytic residue [active]
362242003946	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
362242003947	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
362242003948	substrate binding site [chemical binding]; other site
362242003949	active site
362242003950	catalytic residues [active]
362242003951	heterodimer interface [polypeptide binding]; other site
362242003952	TM2 domain; Region: TM2; pfam05154
362242003953	Protein of unknown function (DUF2752); Region: DUF2752; pfam10825
362242003954	Cutinase; Region: Cutinase; pfam01083
362242003955	pyruvate kinase; Provisional; Region: PRK06247
362242003956	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
362242003957	domain interfaces; other site
362242003958	active site
362242003959	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
362242003960	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
362242003961	active site
362242003962	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
362242003963	catalytic triad [active]
362242003964	dimer interface [polypeptide binding]; other site
362242003965	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
362242003966	thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868
362242003967	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
362242003968	Walker A/P-loop; other site
362242003969	ATP binding site [chemical binding]; other site
362242003970	Q-loop/lid; other site
362242003971	ABC transporter signature motif; other site
362242003972	Walker B; other site
362242003973	D-loop; other site
362242003974	H-loop/switch region; other site
362242003975	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
362242003976	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
362242003977	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
362242003978	Walker A/P-loop; other site
362242003979	ATP binding site [chemical binding]; other site
362242003980	Q-loop/lid; other site
362242003981	ABC transporter signature motif; other site
362242003982	Walker B; other site
362242003983	D-loop; other site
362242003984	H-loop/switch region; other site
362242003985	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
362242003986	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
362242003987	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
362242003988	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
362242003989	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
362242003990	active site
362242003991	phosphorylation site [posttranslational modification]
362242003992	intermolecular recognition site; other site
362242003993	dimerization interface [polypeptide binding]; other site
362242003994	ANTAR domain; Region: ANTAR; pfam03861
362242003995	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
362242003996	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
362242003997	DUF35 OB-fold domain; Region: DUF35; pfam01796
362242003998	DNA polymerase I; Provisional; Region: PRK05755
362242003999	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
362242004000	active site
362242004001	metal binding site 1 [ion binding]; metal-binding site
362242004002	putative 5' ssDNA interaction site; other site
362242004003	metal binding site 3; metal-binding site
362242004004	metal binding site 2 [ion binding]; metal-binding site
362242004005	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
362242004006	putative DNA binding site [nucleotide binding]; other site
362242004007	putative metal binding site [ion binding]; other site
362242004008	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
362242004009	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
362242004010	active site
362242004011	DNA binding site [nucleotide binding]
362242004012	catalytic site [active]
362242004013	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899
362242004014	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
362242004015	RNA binding site [nucleotide binding]; other site
362242004016	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
362242004017	RNA binding site [nucleotide binding]; other site
362242004018	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
362242004019	RNA binding site [nucleotide binding]; other site
362242004020	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
362242004021	RNA binding site [nucleotide binding]; other site
362242004022	dephospho-CoA kinase/protein folding accessory domain-containing protein; Provisional; Region: coaE; PRK03333
362242004023	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
362242004024	CoA-binding site [chemical binding]; other site
362242004025	ATP-binding [chemical binding]; other site
362242004026	Uncharacterized conserved protein [Function unknown]; Region: GrpB; COG2320
362242004027	DNA polymerase Ligase (LigD); Region: LigD_N; cl11819
362242004028	Protein of unknown function (DUF402); Region: DUF402; cl00979
362242004029	excinuclease ABC subunit B; Provisional; Region: PRK05298
362242004030	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
362242004031	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
362242004032	nucleotide binding region [chemical binding]; other site
362242004033	ATP-binding site [chemical binding]; other site
362242004034	Ultra-violet resistance protein B; Region: UvrB; pfam12344
362242004035	UvrB/uvrC motif; Region: UVR; pfam02151
362242004036	Major Facilitator Superfamily; Region: MFS_1; pfam07690
362242004037	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
362242004038	putative substrate translocation pore; other site
362242004039	Predicted membrane protein [Function unknown]; Region: COG5305
362242004040	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
362242004041	Ligand Binding Site [chemical binding]; other site
362242004042	Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631
362242004043	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
362242004044	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
362242004045	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
362242004046	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
362242004047	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
362242004048	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
362242004049	Predicted esterase [General function prediction only]; Region: COG0627
362242004050	lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983
362242004051	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
362242004052	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
362242004053	dimer interface [polypeptide binding]; other site
362242004054	putative anticodon binding site; other site
362242004055	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
362242004056	motif 1; other site
362242004057	dimer interface [polypeptide binding]; other site
362242004058	active site
362242004059	motif 2; other site
362242004060	motif 3; other site
362242004061	translation initiation factor IF-3; Region: infC; TIGR00168
362242004062	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
362242004063	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
362242004064	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
362242004065	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
362242004066	23S rRNA binding site [nucleotide binding]; other site
362242004067	L21 binding site [polypeptide binding]; other site
362242004068	L13 binding site [polypeptide binding]; other site
362242004069	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
362242004070	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
362242004071	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
362242004072	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662
362242004073	PE family; Region: PE; pfam00934
362242004074	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
362242004075	cyclase homology domain; Region: CHD; cd07302
362242004076	nucleotidyl binding site; other site
362242004077	metal binding site [ion binding]; metal-binding site
362242004078	dimer interface [polypeptide binding]; other site
362242004079	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
362242004080	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
362242004081	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
362242004082	dimer interface [polypeptide binding]; other site
362242004083	motif 1; other site
362242004084	active site
362242004085	motif 2; other site
362242004086	motif 3; other site
362242004087	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
362242004088	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
362242004089	putative tRNA-binding site [nucleotide binding]; other site
362242004090	B3/4 domain; Region: B3_4; pfam03483
362242004091	tRNA synthetase B5 domain; Region: B5; pfam03484
362242004092	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
362242004093	dimer interface [polypeptide binding]; other site
362242004094	motif 1; other site
362242004095	motif 3; other site
362242004096	motif 2; other site
362242004097	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
362242004098	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242004099	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242004100	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242004101	PE family; Region: PE; pfam00934
362242004102	PE family; Region: PE; pfam00934
362242004103	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242004104	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242004105	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242004106	Transposase, Mutator family; Region: Transposase_mut; pfam00872
362242004107	MULE transposase domain; Region: MULE; pfam10551
362242004108	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
362242004109	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
362242004110	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
362242004111	heterotetramer interface [polypeptide binding]; other site
362242004112	active site pocket [active]
362242004113	cleavage site
362242004114	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
362242004115	feedback inhibition sensing region; other site
362242004116	homohexameric interface [polypeptide binding]; other site
362242004117	nucleotide binding site [chemical binding]; other site
362242004118	N-acetyl-L-glutamate binding site [chemical binding]; other site
362242004119	acetylornithine aminotransferase; Provisional; Region: argD; PRK03244
362242004120	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
362242004121	inhibitor-cofactor binding pocket; inhibition site
362242004122	pyridoxal 5'-phosphate binding site [chemical binding]; other site
362242004123	catalytic residue [active]
362242004124	ornithine carbamoyltransferase; Provisional; Region: PRK00779
362242004125	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
362242004126	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
362242004127	arginine repressor; Provisional; Region: PRK03341
362242004128	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
362242004129	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
362242004130	argininosuccinate synthase; Provisional; Region: PRK13820
362242004131	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
362242004132	ANP binding site [chemical binding]; other site
362242004133	Substrate Binding Site II [chemical binding]; other site
362242004134	Substrate Binding Site I [chemical binding]; other site
362242004135	argininosuccinate lyase; Provisional; Region: PRK00855
362242004136	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
362242004137	active sites [active]
362242004138	tetramer interface [polypeptide binding]; other site
362242004139	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
362242004140	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
362242004141	active site
362242004142	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
362242004143	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
362242004144	Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424
362242004145	Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831
362242004146	malonyl-CoA binding site [chemical binding]; other site
362242004147	dimer interface [polypeptide binding]; other site
362242004148	active site
362242004149	product binding site; other site
362242004150	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
362242004151	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
362242004152	ABC transporter; Region: ABC_tran_2; pfam12848
362242004153	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
362242004154	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
362242004155	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
362242004156	acyl-CoA synthetase; Validated; Region: PRK07868
362242004157	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
362242004158	acyl-activating enzyme (AAE) consensus motif; other site
362242004159	AMP binding site [chemical binding]; other site
362242004160	active site
362242004161	CoA binding site [chemical binding]; other site
362242004162	Uncharacterized conserved protein [Function unknown]; Region: COG2835
362242004163	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353
362242004164	putative dimer interface [polypeptide binding]; other site
362242004165	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
362242004166	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
362242004167	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
362242004168	ABC-2 type transporter; Region: ABC2_membrane; cl17235
362242004169	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
362242004170	ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864
362242004171	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
362242004172	Walker A/P-loop; other site
362242004173	ATP binding site [chemical binding]; other site
362242004174	Q-loop/lid; other site
362242004175	ABC transporter signature motif; other site
362242004176	Walker B; other site
362242004177	D-loop; other site
362242004178	H-loop/switch region; other site
362242004179	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
362242004180	active site
362242004181	DNA binding site [nucleotide binding]
362242004182	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
362242004183	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
362242004184	active site
362242004185	HIGH motif; other site
362242004186	dimer interface [polypeptide binding]; other site
362242004187	KMSKS motif; other site
362242004188	S4 RNA-binding domain; Region: S4; smart00363
362242004189	RNA binding surface [nucleotide binding]; other site
362242004190	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242004191	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242004192	Double zinc ribbon; Region: DZR; pfam12773
362242004193	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
362242004194	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
362242004195	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242004196	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242004197	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242004198	Uncharacterized conserved protein [Function unknown]; Region: COG3482
362242004199	Protein of unknown function (DUF732); Region: DUF732; pfam05305
362242004200	Tetratrico peptide repeat; Region: TPR_5; pfam12688
362242004201	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
362242004202	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
362242004203	active site
362242004204	motif I; other site
362242004205	motif II; other site
362242004206	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
362242004207	DnaB-like helicase C terminal domain; Region: DnaB_C; pfam03796
362242004208	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
362242004209	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
362242004210	RNA binding surface [nucleotide binding]; other site
362242004211	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
362242004212	S-adenosylmethionine binding site [chemical binding]; other site
362242004213	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372
362242004214	ATP-NAD kinase; Region: NAD_kinase; pfam01513
362242004215	DNA repair protein RecN; Region: recN; TIGR00634
362242004216	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
362242004217	Walker A/P-loop; other site
362242004218	ATP binding site [chemical binding]; other site
362242004219	Q-loop/lid; other site
362242004220	ABC transporter signature motif; other site
362242004221	Walker B; other site
362242004222	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
362242004223	ABC transporter signature motif; other site
362242004224	Walker B; other site
362242004225	D-loop; other site
362242004226	H-loop/switch region; other site
362242004227	Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825
362242004228	Thiamine pyrophosphokinase; Region: TPK; cl08415
362242004229	Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555
362242004230	Protein of unknown function (DUF3186); Region: DUF3186; pfam11382
362242004231	CTP synthetase; Validated; Region: pyrG; PRK05380
362242004232	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
362242004233	Catalytic site [active]
362242004234	active site
362242004235	UTP binding site [chemical binding]; other site
362242004236	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
362242004237	active site
362242004238	putative oxyanion hole; other site
362242004239	catalytic triad [active]
362242004240	nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052
362242004241	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
362242004242	dimer interface [polypeptide binding]; other site
362242004243	ADP-ribose binding site [chemical binding]; other site
362242004244	active site
362242004245	nudix motif; other site
362242004246	metal binding site [ion binding]; metal-binding site
362242004247	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
362242004248	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
362242004249	active site
362242004250	DNA binding site [nucleotide binding]
362242004251	Int/Topo IB signature motif; other site
362242004252	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
362242004253	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
362242004254	S-adenosylmethionine binding site [chemical binding]; other site
362242004255	Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; pfam07994
362242004256	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
362242004257	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
362242004258	Xylose isomerase [Carbohydrate transport and metabolism]; Region: XylA; cl09945
362242004259	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
362242004260	TatD related DNase; Region: TatD_DNase; pfam01026
362242004261	active site
362242004262	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
362242004263	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242004264	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242004265	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242004266	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
362242004267	PPE family; Region: PPE; pfam00823
362242004268	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
362242004269	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
362242004270	PPE family; Region: PPE; pfam00823
362242004271	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
362242004272	MbtH-like protein; Region: MbtH; pfam03621
362242004273	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
362242004274	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
362242004275	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
362242004276	active site
362242004277	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242004278	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242004279	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242004280	spermidine synthase; Provisional; Region: PRK03612
362242004281	Spermine/spermidine synthase; Region: Spermine_synth; pfam01564
362242004282	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
362242004283	Domain of unknown function (DUF4247); Region: DUF4247; pfam14042
362242004284	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242004285	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242004286	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242004287	Protein of unknown function DUF2617; Region: DUF2617; pfam10936
362242004288	Domain of unknown function (DUF4178); Region: DUF4178; pfam13785
362242004289	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
362242004290	active site
362242004291	putative DNA-binding cleft [nucleotide binding]; other site
362242004292	dimer interface [polypeptide binding]; other site
362242004293	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
362242004294	RuvA N terminal domain; Region: RuvA_N; pfam01330
362242004295	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
362242004296	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
362242004297	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
362242004298	Walker A motif; other site
362242004299	ATP binding site [chemical binding]; other site
362242004300	Walker B motif; other site
362242004301	arginine finger; other site
362242004302	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
362242004304	PE family; Region: PE; pfam00934
362242004306	Protein of unknown function (DUF1304); Region: DUF1304; pfam06993
362242004307	PE family; Region: PE; pfam00934
362242004311	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
362242004312	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
362242004313	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
362242004314	acyl-activating enzyme (AAE) consensus motif; other site
362242004315	acyl-activating enzyme (AAE) consensus motif; other site
362242004316	AMP binding site [chemical binding]; other site
362242004317	active site
362242004318	CoA binding site [chemical binding]; other site
362242004319	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
362242004320	Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320
362242004321	extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235
362242004322	putative NAD(P) binding site [chemical binding]; other site
362242004323	active site
362242004324	putative substrate binding site [chemical binding]; other site
362242004325	4-aminobutyrate aminotransferase; Provisional; Region: PRK06058
362242004326	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
362242004327	inhibitor-cofactor binding pocket; inhibition site
362242004328	pyridoxal 5'-phosphate binding site [chemical binding]; other site
362242004329	catalytic residue [active]
362242004330	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05886
362242004331	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
362242004332	Protein export membrane protein; Region: SecD_SecF; cl14618
362242004333	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
362242004334	Protein export membrane protein; Region: SecD_SecF; pfam02355
362242004335	The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501
362242004336	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
362242004337	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
362242004338	active site
362242004339	(p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691
362242004340	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
362242004341	Zn2+ binding site [ion binding]; other site
362242004342	Mg2+ binding site [ion binding]; other site
362242004343	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
362242004344	synthetase active site [active]
362242004345	NTP binding site [chemical binding]; other site
362242004346	metal binding site [ion binding]; metal-binding site
362242004347	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
362242004348	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
362242004349	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
362242004350	active site
362242004351	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
362242004352	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
362242004353	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
362242004354	dimer interface [polypeptide binding]; other site
362242004355	motif 1; other site
362242004356	active site
362242004357	motif 2; other site
362242004358	motif 3; other site
362242004359	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
362242004360	anticodon binding site; other site
362242004361	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
362242004362	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
362242004363	FeS/SAM binding site; other site
362242004364	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
362242004365	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
362242004366	active site
362242004367	nucleophile elbow; other site
362242004368	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
362242004369	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
362242004370	non-specific DNA binding site [nucleotide binding]; other site
362242004371	salt bridge; other site
362242004372	sequence-specific DNA binding site [nucleotide binding]; other site
362242004373	Cupin domain; Region: Cupin_2; pfam07883
362242004374	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
362242004375	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
362242004376	inhibitor site; inhibition site
362242004377	active site
362242004378	dimer interface [polypeptide binding]; other site
362242004379	catalytic residue [active]
362242004380	Predicted metalloprotease [General function prediction only]; Region: COG2321
362242004381	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
362242004382	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
362242004383	putative hydrophobic ligand binding site [chemical binding]; other site
362242004384	protein interface [polypeptide binding]; other site
362242004385	gate; other site
362242004386	2-dehydropantoate 2-reductase; Provisional; Region: PRK12921
362242004387	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
362242004388	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
362242004389	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
362242004390	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
362242004391	dimer interface [polypeptide binding]; other site
362242004392	anticodon binding site; other site
362242004393	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
362242004394	homodimer interface [polypeptide binding]; other site
362242004395	motif 1; other site
362242004396	active site
362242004397	motif 2; other site
362242004398	GAD domain; Region: GAD; pfam02938
362242004399	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
362242004400	active site
362242004401	motif 3; other site
362242004402	Protein of unknown function (DUF419); Region: DUF419; cl15265
362242004403	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
362242004404	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
362242004405	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
362242004406	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307
362242004407	Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005
362242004408	A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448
362242004409	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
362242004410	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
362242004411	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
362242004412	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
362242004413	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
362242004414	Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899
362242004415	Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899
362242004416	Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291
362242004417	recombination factor protein RarA; Reviewed; Region: PRK13342
362242004418	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
362242004419	Walker A motif; other site
362242004420	ATP binding site [chemical binding]; other site
362242004421	Walker B motif; other site
362242004422	arginine finger; other site
362242004423	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
362242004424	Uncharacterized protein family UPF0047; Region: UPF0047; cl00439
362242004425	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
362242004426	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
362242004427	motif 1; other site
362242004428	active site
362242004429	motif 2; other site
362242004430	motif 3; other site
362242004431	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
362242004432	DHHA1 domain; Region: DHHA1; pfam02272
362242004433	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
362242004434	YceG-like family; Region: YceG; pfam02618
362242004435	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
362242004436	dimerization interface [polypeptide binding]; other site
362242004437	shikimate-5-dehydrogenase, fungal AROM-type; Region: Shik-DH-AROM; TIGR01809
362242004438	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
362242004439	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
362242004440	shikimate binding site; other site
362242004441	NAD(P) binding site [chemical binding]; other site
362242004442	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
362242004443	chorismate synthase; Validated; Region: PRK05382
362242004444	Tetramer interface [polypeptide binding]; other site
362242004445	active site
362242004446	FMN-binding site [chemical binding]; other site
362242004447	shikimate kinase; Reviewed; Region: aroK; PRK00131
362242004448	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
362242004449	ADP binding site [chemical binding]; other site
362242004450	magnesium binding site [ion binding]; other site
362242004451	putative shikimate binding site; other site
362242004452	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
362242004453	active site
362242004454	dimer interface [polypeptide binding]; other site
362242004455	metal binding site [ion binding]; metal-binding site
362242004456	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
362242004457	Dehydroquinase class II; Region: DHquinase_II; pfam01220
362242004458	trimer interface [polypeptide binding]; other site
362242004459	active site
362242004460	dimer interface [polypeptide binding]; other site
362242004461	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
362242004462	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
362242004463	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
362242004464	active site
362242004465	elongation factor P; Validated; Region: PRK00529
362242004466	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
362242004467	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
362242004468	RNA binding site [nucleotide binding]; other site
362242004469	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
362242004470	RNA binding site [nucleotide binding]; other site
362242004471	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
362242004472	putative RNA binding site [nucleotide binding]; other site
362242004473	hypothetical protein; Provisional; Region: PRK07236
362242004474	hypothetical protein; Provisional; Region: PRK07588
362242004475	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
362242004476	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
362242004477	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
362242004478	Beta-lactamase; Region: Beta-lactamase; pfam00144
362242004479	Protein of unknown function (DUF1396); Region: DUF1396; pfam07161
362242004480	Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; pfam00173
362242004481	Fatty acid desaturase; Region: FA_desaturase; pfam00487
362242004482	Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424
362242004483	Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831
362242004484	malonyl-CoA binding site [chemical binding]; other site
362242004485	dimer interface [polypeptide binding]; other site
362242004486	active site
362242004487	product binding site; other site
362242004488	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
362242004489	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
362242004490	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
362242004491	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
362242004492	active site
362242004493	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
362242004494	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
362242004495	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
362242004496	dihydroorotase; Validated; Region: pyrC; PRK09357
362242004497	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
362242004498	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
362242004499	active site
362242004500	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
362242004501	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
362242004502	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
362242004503	catalytic site [active]
362242004504	subunit interface [polypeptide binding]; other site
362242004505	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
362242004506	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
362242004507	ATP-grasp domain; Region: ATP-grasp_4; cl17255
362242004508	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
362242004509	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
362242004510	ATP-grasp domain; Region: ATP-grasp_4; cl17255
362242004511	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
362242004512	IMP binding site; other site
362242004513	dimer interface [polypeptide binding]; other site
362242004514	interdomain contacts; other site
362242004515	partial ornithine binding site; other site
362242004516	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
362242004517	active site
362242004518	dimer interface [polypeptide binding]; other site
362242004519	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
362242004520	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
362242004521	catalytic site [active]
362242004522	G-X2-G-X-G-K; other site
362242004523	DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690
362242004524	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
362242004525	Flavoprotein; Region: Flavoprotein; pfam02441
362242004526	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
362242004527	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
362242004528	S-adenosylmethionine synthetase; Validated; Region: PRK05250
362242004529	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
362242004530	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
362242004531	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
362242004532	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
362242004533	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
362242004534	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
362242004535	substrate binding pocket [chemical binding]; other site
362242004536	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
362242004537	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
362242004538	substrate binding pocket [chemical binding]; other site
362242004539	Predicted membrane protein [Function unknown]; Region: COG3714
362242004540	primosome assembly protein PriA; Provisional; Region: PRK14873
362242004541	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
362242004542	S-adenosylmethionine binding site [chemical binding]; other site
362242004543	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242004544	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242004545	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242004546	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
362242004547	MarR family; Region: MarR; pfam01047
362242004548	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
362242004549	S-adenosylmethionine binding site [chemical binding]; other site
362242004550	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
362242004551	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
362242004552	putative active site [active]
362242004553	substrate binding site [chemical binding]; other site
362242004554	putative cosubstrate binding site; other site
362242004555	catalytic site [active]
362242004556	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
362242004557	substrate binding site [chemical binding]; other site
362242004558	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
362242004559	putative RNA binding site [nucleotide binding]; other site
362242004560	16S rRNA methyltransferase B; Provisional; Region: PRK14902
362242004561	NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446
362242004562	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
362242004563	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
362242004564	substrate binding site [chemical binding]; other site
362242004565	hexamer interface [polypeptide binding]; other site
362242004566	metal binding site [ion binding]; metal-binding site
362242004567	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
362242004568	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
362242004569	catalytic motif [active]
362242004570	Zn binding site [ion binding]; other site
362242004571	RibD C-terminal domain; Region: RibD_C; pfam01872
362242004572	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
362242004573	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
362242004574	Protein of unknown function (DUF1396); Region: DUF1396; pfam07161
362242004575	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
362242004576	Lumazine binding domain; Region: Lum_binding; pfam00677
362242004577	Lumazine binding domain; Region: Lum_binding; pfam00677
362242004578	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
362242004579	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
362242004580	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
362242004581	dimerization interface [polypeptide binding]; other site
362242004582	active site
362242004583	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
362242004584	homopentamer interface [polypeptide binding]; other site
362242004585	active site
362242004586	Protein of unknown function (DUF2581); Region: DUF2581; pfam10756
362242004587	PknH-like extracellular domain; Region: PknH_C; pfam14032
362242004588	Domain of unknown function (DUF222); Region: DUF222; pfam02720
362242004589	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
362242004590	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
362242004591	active site
362242004592	GIY-YIG motif/motif A; other site
362242004593	catalytic site [active]
362242004594	putative DNA binding site [nucleotide binding]; other site
362242004595	metal binding site [ion binding]; metal-binding site
362242004596	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
362242004597	Helix-hairpin-helix motif; Region: HHH; pfam00633
362242004598	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
362242004599	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
362242004600	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
362242004601	phosphate binding site [ion binding]; other site
362242004602	putative substrate binding pocket [chemical binding]; other site
362242004603	dimer interface [polypeptide binding]; other site
362242004604	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
362242004605	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
362242004606	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
362242004607	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
362242004608	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
362242004609	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
362242004610	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
362242004611	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
362242004612	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
362242004613	putative acyl-acceptor binding pocket; other site
362242004614	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242004615	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242004616	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
362242004617	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
362242004618	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
362242004619	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
362242004620	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
362242004621	Phosphoglycerate kinase; Region: PGK; pfam00162
362242004622	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
362242004623	substrate binding site [chemical binding]; other site
362242004624	hinge regions; other site
362242004625	ADP binding site [chemical binding]; other site
362242004626	catalytic site [active]
362242004627	triosephosphate isomerase; Provisional; Region: PRK14567
362242004628	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
362242004629	substrate binding site [chemical binding]; other site
362242004630	dimer interface [polypeptide binding]; other site
362242004631	catalytic triad [active]
362242004632	Transcriptional regulators [Transcription]; Region: GntR; COG1802
362242004633	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
362242004634	DNA-binding site [nucleotide binding]; DNA binding site
362242004635	FCD domain; Region: FCD; pfam07729
362242004636	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
362242004637	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
362242004638	PE family; Region: PE; pfam00934
362242004641	PE family; Region: PE; pfam00934
362242004642	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
362242004643	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
362242004644	putative active site [active]
362242004645	glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534
362242004646	Glucose-6-P dehydrogenase subunit [Carbohydrate transport and metabolism]; Region: COG3429
362242004647	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
362242004648	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
362242004649	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
362242004650	Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955
362242004651	putative active site [active]
362242004652	transaldolase; Provisional; Region: PRK03903
362242004653	catalytic residue [active]
362242004654	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
362242004655	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
362242004656	TPP-binding site [chemical binding]; other site
362242004657	dimer interface [polypeptide binding]; other site
362242004658	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
362242004659	PYR/PP interface [polypeptide binding]; other site
362242004660	dimer interface [polypeptide binding]; other site
362242004661	TPP binding site [chemical binding]; other site
362242004662	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
362242004663	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
362242004664	UbiA prenyltransferase family; Region: UbiA; pfam01040
362242004665	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242004666	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242004667	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242004668	Transposase, Mutator family; Region: Transposase_mut; pfam00872
362242004669	MULE transposase domain; Region: MULE; pfam10551
362242004670	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242004671	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242004672	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242004673	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
362242004674	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
362242004675	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
362242004676	NADP binding site [chemical binding]; other site
362242004677	dimer interface [polypeptide binding]; other site
362242004678	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
362242004679	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
362242004680	ABC-2 type transporter; Region: ABC2_membrane; cl17235
362242004681	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
362242004682	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
362242004683	Walker A/P-loop; other site
362242004684	ATP binding site [chemical binding]; other site
362242004685	Q-loop/lid; other site
362242004686	ABC transporter signature motif; other site
362242004687	Walker B; other site
362242004688	D-loop; other site
362242004689	H-loop/switch region; other site
362242004690	carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459
362242004691	Predicted transcriptional regulator [Transcription]; Region: COG2345
362242004692	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
362242004693	dimerization interface [polypeptide binding]; other site
362242004694	putative DNA binding site [nucleotide binding]; other site
362242004695	putative Zn2+ binding site [ion binding]; other site
362242004696	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
362242004697	FeS assembly protein SufB; Region: sufB; TIGR01980
362242004698	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
362242004699	FeS assembly protein SufD; Region: sufD; TIGR01981
362242004700	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
362242004701	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
362242004702	Walker A/P-loop; other site
362242004703	ATP binding site [chemical binding]; other site
362242004704	Q-loop/lid; other site
362242004705	ABC transporter signature motif; other site
362242004706	Walker B; other site
362242004707	D-loop; other site
362242004708	H-loop/switch region; other site
362242004709	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
362242004710	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
362242004711	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
362242004712	catalytic residue [active]
362242004713	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
362242004714	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
362242004715	trimerization site [polypeptide binding]; other site
362242004716	active site
362242004717	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
362242004718	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
362242004719	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
362242004720	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
362242004721	active site
362242004722	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
362242004723	PE family; Region: PE; pfam00934
362242004724	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242004725	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242004726	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242004727	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
362242004728	catalytic residues [active]
362242004729	ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600
362242004730	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188
362242004731	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
362242004732	Class I ribonucleotide reductase; Region: RNR_I; cd01679
362242004733	active site
362242004734	dimer interface [polypeptide binding]; other site
362242004735	catalytic residues [active]
362242004736	effector binding site; other site
362242004737	R2 peptide binding site; other site
362242004738	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
362242004739	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
362242004740	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
362242004741	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
362242004742	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
362242004743	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
362242004744	Ligand-binding SRPBCC domain of Streptococcus mutans Smu.440 and related proteins; Region: SRPBCC_Smu440-like; cd08862
362242004745	putative hydrophobic ligand binding site [chemical binding]; other site
362242004746	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
362242004747	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
362242004748	dimer interface [polypeptide binding]; other site
362242004749	putative radical transfer pathway; other site
362242004750	diiron center [ion binding]; other site
362242004751	tyrosyl radical; other site
362242004752	Protein of unknown function (DUF3349); Region: DUF3349; pfam11829
362242004753	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
362242004754	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
362242004755	putative NAD(P) binding site [chemical binding]; other site
362242004756	putative substrate binding site [chemical binding]; other site
362242004757	catalytic Zn binding site [ion binding]; other site
362242004758	structural Zn binding site [ion binding]; other site
362242004759	dimer interface [polypeptide binding]; other site
362242004760	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
362242004761	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
362242004762	siderophore binding site; other site
362242004763	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
362242004764	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
362242004765	D-pathway; other site
362242004766	Putative ubiquinol binding site [chemical binding]; other site
362242004767	Low-spin heme (heme b) binding site [chemical binding]; other site
362242004768	Putative water exit pathway; other site
362242004769	Binuclear center (heme o3/CuB) [ion binding]; other site
362242004770	K-pathway; other site
362242004771	Putative proton exit pathway; other site
362242004772	CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870
362242004773	ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871
362242004774	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
362242004775	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
362242004776	motif II; other site
362242004777	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242004778	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242004779	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242004780	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194
362242004781	hydrogenase 4 subunit B; Validated; Region: PRK06521
362242004782	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
362242004783	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
362242004784	Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; cl17899
362242004785	hydrogenase 4 subunit F; Validated; Region: PRK06458
362242004786	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
362242004787	ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119
362242004788	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
362242004789	Walker A/P-loop; other site
362242004790	ATP binding site [chemical binding]; other site
362242004791	Q-loop/lid; other site
362242004792	ABC transporter signature motif; other site
362242004793	Walker B; other site
362242004794	D-loop; other site
362242004795	H-loop/switch region; other site
362242004796	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
362242004797	nudix motif; other site
362242004798	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
362242004799	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
362242004800	substrate binding site [chemical binding]; other site
362242004801	oxyanion hole (OAH) forming residues; other site
362242004802	trimer interface [polypeptide binding]; other site
362242004803	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
362242004804	S-adenosylmethionine binding site [chemical binding]; other site
362242004805	Predicted RNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG2263
362242004806	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
362242004807	FOG: WD40-like repeat [Function unknown]; Region: COG1520
362242004808	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
362242004809	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
362242004810	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
362242004811	trimer interface [polypeptide binding]; other site
362242004812	active site
362242004813	substrate binding site [chemical binding]; other site
362242004814	CoA binding site [chemical binding]; other site
362242004815	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
362242004816	Domain of unknown function (DUF4333); Region: DUF4333; pfam14230
362242004817	Domain of unknown function (DUF4333); Region: DUF4333; pfam14230
362242004818	DNA photolyase; Region: DNA_photolyase; pfam00875
362242004819	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
362242004820	TspO/MBR family; Region: TspO_MBR; pfam03073
362242004821	MMPL family; Region: MMPL; pfam03176
362242004822	MMPL family; Region: MMPL; pfam03176
362242004823	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242004824	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242004825	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242004826	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
362242004827	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
362242004828	NAD(P) binding site [chemical binding]; other site
362242004829	active site
362242004830	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
362242004831	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
362242004832	Uncharacterized conserved protein [Function unknown]; Region: COG1543
362242004833	Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191
362242004834	Domain of unknown function (DUF1957); Region: DUF1957; pfam09210
362242004835	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
362242004836	S-adenosylmethionine binding site [chemical binding]; other site
362242004837	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
362242004838	Ligand binding site [chemical binding]; other site
362242004839	Electron transfer flavoprotein domain; Region: ETF; pfam01012
362242004840	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
362242004841	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
362242004842	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
362242004843	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496
362242004844	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
362242004845	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
362242004846	putative acyl-acceptor binding pocket; other site
362242004847	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
362242004848	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
362242004849	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
362242004850	catalytic residue [active]
362242004851	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
362242004852	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
362242004853	Ligand Binding Site [chemical binding]; other site
362242004854	PknH-like extracellular domain; Region: PknH_C; pfam14032
362242004855	CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310
362242004856	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242004857	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242004858	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242004859	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
362242004860	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
362242004861	nucleotide binding pocket [chemical binding]; other site
362242004862	K-X-D-G motif; other site
362242004863	catalytic site [active]
362242004864	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
362242004865	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
362242004866	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
362242004867	Dimer interface [polypeptide binding]; other site
362242004868	BRCT sequence motif; other site
362242004869	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
362242004870	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
362242004871	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
362242004872	ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887
362242004873	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
362242004874	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
362242004875	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
362242004876	6-phosphofructokinase; Provisional; Region: PRK03202
362242004877	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
362242004878	active site
362242004879	ADP/pyrophosphate binding site [chemical binding]; other site
362242004880	dimerization interface [polypeptide binding]; other site
362242004881	allosteric effector site; other site
362242004882	fructose-1,6-bisphosphate binding site; other site
362242004883	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
362242004884	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
362242004885	GatB domain; Region: GatB_Yqey; smart00845
362242004886	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
362242004887	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
362242004888	Predicted membrane protein [Function unknown]; Region: COG2259
362242004889	Protein of unknown function (DUF2581); Region: DUF2581; pfam10756
362242004890	acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789
362242004891	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
362242004892	PYR/PP interface [polypeptide binding]; other site
362242004893	dimer interface [polypeptide binding]; other site
362242004894	TPP binding site [chemical binding]; other site
362242004895	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
362242004896	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
362242004897	TPP-binding site [chemical binding]; other site
362242004898	dimer interface [polypeptide binding]; other site
362242004899	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
362242004900	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
362242004901	putative valine binding site [chemical binding]; other site
362242004902	dimer interface [polypeptide binding]; other site
362242004903	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
362242004904	ketol-acid reductoisomerase; Provisional; Region: PRK05479
362242004905	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
362242004906	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
362242004907	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
362242004908	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
362242004909	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
362242004910	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
362242004911	ligand binding site [chemical binding]; other site
362242004912	NAD binding site [chemical binding]; other site
362242004913	dimerization interface [polypeptide binding]; other site
362242004914	catalytic site [active]
362242004915	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
362242004916	putative L-serine binding site [chemical binding]; other site
362242004917	3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437
362242004918	tartrate dehydrogenase; Region: TTC; TIGR02089
362242004919	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
362242004920	Domain of unknown function (DUF2437); Region: DUF2437; pfam10370
362242004921	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
362242004922	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
362242004923	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
362242004924	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
362242004925	active site
362242004926	KMSKS motif; other site
362242004927	PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618
362242004928	Nitronate monooxygenase; Region: NMO; pfam03060
362242004929	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
362242004930	FMN binding site [chemical binding]; other site
362242004931	substrate binding site [chemical binding]; other site
362242004932	putative catalytic residue [active]
362242004933	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242004934	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242004935	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242004936	Transposase, Mutator family; Region: Transposase_mut; pfam00872
362242004937	MULE transposase domain; Region: MULE; pfam10551
362242004938	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
362242004939	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
362242004940	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
362242004941	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
362242004942	catalytic residue [active]
362242004943	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
362242004944	Transcriptional regulator [Transcription]; Region: IclR; COG1414
362242004945	Bacterial transcriptional regulator; Region: IclR; pfam01614
362242004946	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
362242004947	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
362242004948	substrate binding site [chemical binding]; other site
362242004949	ligand binding site [chemical binding]; other site
362242004950	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
362242004951	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
362242004952	substrate binding site [chemical binding]; other site
362242004953	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
362242004954	IHF - DNA interface [nucleotide binding]; other site
362242004955	IHF dimer interface [polypeptide binding]; other site
362242004956	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
362242004957	active site
362242004958	Ap6A binding site [chemical binding]; other site
362242004959	nudix motif; other site
362242004960	metal binding site [ion binding]; metal-binding site
362242004961	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
362242004962	catalytic core [active]
362242004963	polyphosphate kinase; Provisional; Region: PRK05443
362242004964	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
362242004965	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
362242004966	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
362242004967	putative domain interface [polypeptide binding]; other site
362242004968	putative active site [active]
362242004969	catalytic site [active]
362242004970	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
362242004971	putative active site [active]
362242004972	catalytic site [active]
362242004973	Guanylyl transferase CofC like; Region: CofC; cl17472
362242004974	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
362242004975	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
362242004976	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
362242004977	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
362242004978	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
362242004979	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
362242004980	Protein of unknown function (DUF3515); Region: DUF3515; pfam12028
362242004981	thiamine monophosphate kinase; Provisional; Region: PRK05731
362242004982	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
362242004983	ATP binding site [chemical binding]; other site
362242004984	dimerization interface [polypeptide binding]; other site
362242004985	Protein of unknown function (DUF1330); Region: DUF1330; cl02288
362242004986	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
362242004987	ligand binding site [chemical binding]; other site
362242004988	active site
362242004989	UGI interface [polypeptide binding]; other site
362242004990	catalytic site [active]
362242004991	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
362242004992	dimer interface [polypeptide binding]; other site
362242004993	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
362242004994	RecG-like helicase [DNA replication, recombination, and repair / Transcription]; Region: RecG; COG1200
362242004995	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
362242004996	generic binding surface II; other site
362242004997	ssDNA binding site; other site
362242004998	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
362242004999	ATP binding site [chemical binding]; other site
362242005000	putative Mg++ binding site [ion binding]; other site
362242005001	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
362242005002	nucleotide binding region [chemical binding]; other site
362242005003	ATP-binding site [chemical binding]; other site
362242005004	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
362242005005	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
362242005006	active site
362242005007	catalytic tetrad [active]
362242005008	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
362242005009	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
362242005010	DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972
362242005011	catalytic residues [active]
362242005012	Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922
362242005013	putative active site [active]
362242005014	redox center [active]
362242005015	pyruvate carboxylase; Reviewed; Region: PRK12999
362242005016	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
362242005017	ATP-grasp domain; Region: ATP-grasp_4; cl17255
362242005018	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
362242005019	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
362242005020	active site
362242005021	catalytic residues [active]
362242005022	metal binding site [ion binding]; metal-binding site
362242005023	homodimer binding site [polypeptide binding]; other site
362242005024	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
362242005025	carboxyltransferase (CT) interaction site; other site
362242005026	biotinylation site [posttranslational modification]; other site
362242005027	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
362242005028	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
362242005029	active site
362242005030	(T/H)XGH motif; other site
362242005031	Predicted permease; Region: DUF318; pfam03773
362242005032	Methyltransferase domain; Region: Methyltransf_24; pfam13578
362242005033	Uncharacterized conserved protein [Function unknown]; Region: COG3268
362242005034	acyl-CoA synthetase; Validated; Region: PRK05850
362242005035	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
362242005036	acyl-activating enzyme (AAE) consensus motif; other site
362242005037	active site
362242005038	4-hydroxybenzoate synthetase (chorismate lyase) [Coenzyme metabolism]; Region: UbiC; COG3161
362242005039	acyl-CoA synthetase; Validated; Region: PRK06060
362242005040	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
362242005041	acyl-activating enzyme (AAE) consensus motif; other site
362242005042	AMP binding site [chemical binding]; other site
362242005043	active site
362242005044	CoA binding site [chemical binding]; other site
362242005045	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
362242005046	Erythronolide synthase docking; Region: Docking; pfam08990
362242005047	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
362242005048	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
362242005049	active site
362242005050	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
362242005051	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
362242005052	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
362242005053	Enoylreductase; Region: PKS_ER; smart00829
362242005054	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
362242005055	NAD(P) binding site [chemical binding]; other site
362242005056	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956
362242005057	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
362242005058	putative NADP binding site [chemical binding]; other site
362242005059	active site
362242005060	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
362242005061	Protein of unknown function (DUF1396); Region: DUF1396; pfam07161
362242005062	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
362242005063	acyl-CoA synthetase; Validated; Region: PRK05850
362242005064	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
362242005065	acyl-activating enzyme (AAE) consensus motif; other site
362242005066	active site
362242005067	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
362242005068	S-adenosylmethionine binding site [chemical binding]; other site
362242005069	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
362242005070	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
362242005071	active site
362242005072	Acyl transferase domain; Region: Acyl_transf_1; pfam00698
362242005073	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
362242005074	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
362242005075	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
362242005076	Enoylreductase; Region: PKS_ER; smart00829
362242005077	NAD(P) binding site [chemical binding]; other site
362242005078	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
362242005079	KR domain; Region: KR; pfam08659
362242005080	putative NADP binding site [chemical binding]; other site
362242005081	active site
362242005082	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
362242005083	acyltransferase PapA5; Provisional; Region: PRK09294
362242005084	ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025
362242005085	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
362242005086	ABC-2 type transporter; Region: ABC2_membrane; cl17235
362242005087	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
362242005088	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
362242005089	daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
362242005090	Walker A/P-loop; other site
362242005091	ATP binding site [chemical binding]; other site
362242005092	Q-loop/lid; other site
362242005093	ABC transporter signature motif; other site
362242005094	Walker B; other site
362242005095	D-loop; other site
362242005096	H-loop/switch region; other site
362242005097	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
362242005098	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
362242005099	active site
362242005100	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
362242005101	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
362242005102	Condensation domain; Region: Condensation; pfam00668
362242005103	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
362242005104	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
362242005105	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
362242005106	active site
362242005107	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
362242005108	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
362242005109	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
362242005110	KR domain; Region: KR; pfam08659
362242005111	putative NADP binding site [chemical binding]; other site
362242005112	active site
362242005113	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
362242005114	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
362242005115	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
362242005116	active site
362242005117	Acyl transferase domain; Region: Acyl_transf_1; cl08282
362242005118	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
362242005119	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
362242005120	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
362242005121	Enoylreductase; Region: PKS_ER; smart00829
362242005122	NAD(P) binding site [chemical binding]; other site
362242005123	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
362242005124	KR domain; Region: KR; pfam08659
362242005125	putative NADP binding site [chemical binding]; other site
362242005126	active site
362242005127	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
362242005128	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
362242005129	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
362242005130	active site
362242005131	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
362242005132	Acyl transferase domain; Region: Acyl_transf_1; cl08282
362242005133	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
362242005134	KR domain; Region: KR; pfam08659
362242005135	putative NADP binding site [chemical binding]; other site
362242005136	active site
362242005137	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
362242005138	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
362242005139	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
362242005140	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
362242005141	active site
362242005142	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
362242005143	Acyl transferase domain; Region: Acyl_transf_1; cl08282
362242005144	ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274
362242005145	KR domain; Region: KR; pfam08659
362242005146	NADP binding site [chemical binding]; other site
362242005147	active site
362242005148	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
362242005149	acyl-CoA synthetase; Validated; Region: PRK05850
362242005150	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
362242005151	acyl-activating enzyme (AAE) consensus motif; other site
362242005152	active site
362242005153	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242005154	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242005155	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
362242005156	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242005157	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242005158	Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599
362242005159	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
362242005160	Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399
362242005161	ribonuclease III; Reviewed; Region: rnc; PRK00102
362242005162	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
362242005163	dimerization interface [polypeptide binding]; other site
362242005164	active site
362242005165	metal binding site [ion binding]; metal-binding site
362242005166	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
362242005167	dsRNA binding site [nucleotide binding]; other site
362242005168	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
362242005169	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
362242005170	DNA binding site [nucleotide binding]
362242005171	catalytic residue [active]
362242005172	H2TH interface [polypeptide binding]; other site
362242005173	putative catalytic residues [active]
362242005174	turnover-facilitating residue; other site
362242005175	intercalation triad [nucleotide binding]; other site
362242005176	8OG recognition residue [nucleotide binding]; other site
362242005177	putative reading head residues; other site
362242005178	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
362242005179	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
362242005180	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
362242005181	acylphosphatase; Provisional; Region: PRK14422
362242005182	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
362242005183	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
362242005184	Walker A/P-loop; other site
362242005185	ATP binding site [chemical binding]; other site
362242005186	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
362242005187	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
362242005188	ABC transporter signature motif; other site
362242005189	Walker B; other site
362242005190	D-loop; other site
362242005191	H-loop/switch region; other site
362242005192	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
362242005193	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
362242005194	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
362242005195	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
362242005196	Nitrogen regulatory protein P-II; Region: P-II; smart00938
362242005197	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
362242005198	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
362242005199	ATP binding site [chemical binding]; other site
362242005200	putative Mg++ binding site [ion binding]; other site
362242005201	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
362242005202	ATP-binding site [chemical binding]; other site
362242005203	signal recognition particle protein; Provisional; Region: PRK10867
362242005204	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
362242005205	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
362242005206	P loop; other site
362242005207	GTP binding site [chemical binding]; other site
362242005208	Signal peptide binding domain; Region: SRP_SPB; pfam02978
362242005209	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
362242005210	Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299
362242005211	active site
362242005212	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
362242005213	Catalytic domain of Protein Kinases; Region: PKc; cd00180
362242005214	active site
362242005215	substrate binding site [chemical binding]; other site
362242005216	ATP binding site [chemical binding]; other site
362242005217	activation loop (A-loop); other site
362242005218	N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653
362242005219	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
362242005220	active site
362242005221	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
362242005222	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
362242005223	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
362242005224	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
362242005225	SnoaL-like domain; Region: SnoaL_4; pfam13577
362242005226	30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520
362242005227	hypothetical protein; Provisional; Region: PRK02821
362242005228	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
362242005229	G-X-X-G motif; other site
362242005230	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
362242005231	RimM N-terminal domain; Region: RimM; pfam01782
362242005232	PRC-barrel domain; Region: PRC; pfam05239
362242005233	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
362242005234	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
362242005235	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
362242005236	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
362242005237	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
362242005238	Catalytic site [active]
362242005239	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
362242005240	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
362242005241	RNA/DNA hybrid binding site [nucleotide binding]; other site
362242005242	active site
362242005243	Protein of unknown function (DUF2469); Region: DUF2469; pfam10611
362242005244	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
362242005245	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
362242005246	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
362242005247	NAD(P) binding site [chemical binding]; other site
362242005248	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
362242005249	active site
362242005250	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
362242005251	hypothetical protein; Reviewed; Region: PRK12497
362242005252	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
362242005253	DNA protecting protein DprA; Region: dprA; TIGR00732
362242005254	Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775
362242005255	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
362242005256	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
362242005257	FAD binding pocket [chemical binding]; other site
362242005258	FAD binding motif [chemical binding]; other site
362242005259	phosphate binding motif [ion binding]; other site
362242005260	NAD binding pocket [chemical binding]; other site
362242005261	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
362242005262	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
362242005263	active site
362242005264	DNA binding site [nucleotide binding]
362242005265	Int/Topo IB signature motif; other site
362242005266	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
362242005267	rRNA interaction site [nucleotide binding]; other site
362242005268	S8 interaction site; other site
362242005269	putative laminin-1 binding site; other site
362242005270	elongation factor Ts; Provisional; Region: tsf; PRK09377
362242005271	UBA/TS-N domain; Region: UBA; pfam00627
362242005272	Elongation factor TS; Region: EF_TS; pfam00889
362242005273	Elongation factor TS; Region: EF_TS; pfam00889
362242005274	amidase; Provisional; Region: PRK07869
362242005275	Amidase; Region: Amidase; pfam01425
362242005276	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
362242005277	MarR family; Region: MarR; pfam01047
362242005278	Domain of unknown function (DUF1942); Region: DUF1942; pfam09167
362242005279	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
362242005280	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
362242005281	putative acyl-acceptor binding pocket; other site
362242005282	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
362242005283	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
362242005284	DNA binding site [nucleotide binding]
362242005285	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
362242005286	putative nucleotide binding site [chemical binding]; other site
362242005287	uridine monophosphate binding site [chemical binding]; other site
362242005288	homohexameric interface [polypeptide binding]; other site
362242005289	ribosome recycling factor; Reviewed; Region: frr; PRK00083
362242005290	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
362242005291	hinge region; other site
362242005292	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
362242005293	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
362242005294	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459
362242005295	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
362242005296	FeS/SAM binding site; other site
362242005297	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
362242005298	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
362242005299	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
362242005300	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242005301	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242005302	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242005303	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
362242005304	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
362242005305	TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012
362242005306	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
362242005307	catalytic residues [active]
362242005308	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
362242005309	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
362242005310	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
362242005311	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
362242005312	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
362242005313	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
362242005314	active site
362242005315	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
362242005316	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
362242005317	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
362242005318	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
362242005319	Predicted acetyltransferase [General function prediction only]; Region: COG3393
362242005320	Domain of unknown function (DUF4081); Region: DUF4081; pfam13312
362242005321	NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223
362242005322	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
362242005323	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
362242005324	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
362242005325	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
362242005326	active site
362242005327	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
362242005328	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
362242005329	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
362242005330	catalytic triad [active]
362242005331	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
362242005332	PPE family; Region: PPE; pfam00823
362242005333	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
362242005334	PPE family; Region: PPE; pfam00823
362242005335	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
362242005336	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
362242005337	malate:quinone oxidoreductase; Validated; Region: PRK05257
362242005338	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
362242005339	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
362242005340	Coenzyme A binding pocket [chemical binding]; other site
362242005341	cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442
362242005342	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
362242005343	Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451
362242005344	metal ion-dependent adhesion site (MIDAS); other site
362242005345	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
362242005346	cob(I)alamin adenolsyltransferase/cobinamide ATP-dependent adenolsyltransferase; Validated; Region: PRK05986
362242005347	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
362242005348	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
362242005349	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
362242005350	catalytic triad [active]
362242005351	Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648
362242005352	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
362242005353	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
362242005354	active site
362242005355	SAM binding site [chemical binding]; other site
362242005356	homodimer interface [polypeptide binding]; other site
362242005357	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
362242005358	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
362242005359	putative substrate translocation pore; other site
362242005360	prolyl-tRNA synthetase; Provisional; Region: PRK09194
362242005361	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
362242005362	dimer interface [polypeptide binding]; other site
362242005363	motif 1; other site
362242005364	active site
362242005365	motif 2; other site
362242005366	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
362242005367	putative deacylase active site [active]
362242005368	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
362242005369	active site
362242005370	motif 3; other site
362242005371	HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266
362242005372	anticodon binding site; other site
362242005373	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
362242005374	dinuclear metal binding motif [ion binding]; other site
362242005375	ribosome maturation protein RimP; Reviewed; Region: PRK00092
362242005376	Sm and related proteins; Region: Sm_like; cl00259
362242005377	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
362242005378	putative oligomer interface [polypeptide binding]; other site
362242005379	putative RNA binding site [nucleotide binding]; other site
362242005380	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
362242005381	NusA N-terminal domain; Region: NusA_N; pfam08529
362242005382	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
362242005383	RNA binding site [nucleotide binding]; other site
362242005384	homodimer interface [polypeptide binding]; other site
362242005385	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
362242005386	G-X-X-G motif; other site
362242005387	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
362242005388	G-X-X-G motif; other site
362242005389	Protein of unknown function (DUF448); Region: DUF448; pfam04296
362242005390	putative RNA binding cleft [nucleotide binding]; other site
362242005391	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
362242005392	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
362242005393	Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532
362242005394	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
362242005395	G1 box; other site
362242005396	putative GEF interaction site [polypeptide binding]; other site
362242005397	GTP/Mg2+ binding site [chemical binding]; other site
362242005398	Switch I region; other site
362242005399	G2 box; other site
362242005400	G3 box; other site
362242005401	Switch II region; other site
362242005402	G4 box; other site
362242005403	G5 box; other site
362242005404	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
362242005405	Translation-initiation factor 2; Region: IF-2; pfam11987
362242005406	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
362242005407	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
362242005408	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
362242005409	DHH family; Region: DHH; pfam01368
362242005410	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
362242005411	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
362242005412	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
362242005413	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
362242005414	dimer interface [polypeptide binding]; other site
362242005415	conserved gate region; other site
362242005416	putative PBP binding loops; other site
362242005417	ABC-ATPase subunit interface; other site
362242005418	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242005419	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242005420	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242005421	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
362242005422	PPE family; Region: PPE; pfam00823
362242005423	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
362242005424	Predicted acyl esterases [General function prediction only]; Region: COG2936
362242005425	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
362242005426	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939
362242005427	Protein of unknown function (DUF3558); Region: DUF3558; pfam12079
362242005428	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
362242005429	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
362242005430	active site
362242005431	metal binding site [ion binding]; metal-binding site
362242005432	Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977
362242005433	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
362242005434	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287
362242005435	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
362242005436	RNA binding site [nucleotide binding]; other site
362242005437	active site
362242005438	tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142
362242005439	lipid-transfer protein; Provisional; Region: PRK08256
362242005440	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
362242005441	active site
362242005442	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
362242005443	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
362242005444	active site
362242005445	Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
362242005446	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
362242005447	putative DNA binding site [nucleotide binding]; other site
362242005448	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
362242005449	FeoA domain; Region: FeoA; pfam04023
362242005450	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
362242005451	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
362242005452	active site
362242005453	Riboflavin kinase; Region: Flavokinase; pfam01687
362242005454	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
362242005455	16S/18S rRNA binding site [nucleotide binding]; other site
362242005456	S13e-L30e interaction site [polypeptide binding]; other site
362242005457	25S rRNA binding site [nucleotide binding]; other site
362242005458	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
362242005459	guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696
362242005460	RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114
362242005461	oligomer interface [polypeptide binding]; other site
362242005462	RNA binding site [nucleotide binding]; other site
362242005463	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
362242005464	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
362242005465	RNase E interface [polypeptide binding]; other site
362242005466	trimer interface [polypeptide binding]; other site
362242005467	active site
362242005468	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
362242005469	putative nucleic acid binding region [nucleotide binding]; other site
362242005470	G-X-X-G motif; other site
362242005471	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
362242005472	RNA binding site [nucleotide binding]; other site
362242005473	domain interface; other site
362242005474	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242005475	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242005476	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242005477	Nitronate monooxygenase; Region: NMO; pfam03060
362242005478	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
362242005479	FMN binding site [chemical binding]; other site
362242005480	substrate binding site [chemical binding]; other site
362242005481	putative catalytic residue [active]
362242005482	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
362242005483	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
362242005484	hexamer interface [polypeptide binding]; other site
362242005485	ligand binding site [chemical binding]; other site
362242005486	putative active site [active]
362242005487	NAD(P) binding site [chemical binding]; other site
362242005488	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
362242005489	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
362242005490	putative DNA binding site [nucleotide binding]; other site
362242005491	putative Zn2+ binding site [ion binding]; other site
362242005492	AsnC family; Region: AsnC_trans_reg; pfam01037
362242005493	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
362242005494	hydrophobic ligand binding site; other site
362242005495	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
362242005496	Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118
362242005497	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
362242005498	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
362242005499	FMN-binding pocket [chemical binding]; other site
362242005500	flavin binding motif; other site
362242005501	phosphate binding motif [ion binding]; other site
362242005502	beta-alpha-beta structure motif; other site
362242005503	NAD binding pocket [chemical binding]; other site
362242005504	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
362242005505	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
362242005506	catalytic loop [active]
362242005507	iron binding site [ion binding]; other site
362242005508	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
362242005509	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
362242005510	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
362242005511	[2Fe-2S] cluster binding site [ion binding]; other site
362242005512	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
362242005513	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
362242005514	intersubunit interface [polypeptide binding]; other site
362242005515	dihydrodipicolinate reductase; Provisional; Region: PRK00048
362242005516	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
362242005517	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
362242005518	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
362242005519	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
362242005521	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
362242005522	PPE family; Region: PPE; pfam00823
362242005523	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
362242005524	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
362242005525	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242005526	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242005527	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
362242005528	classical (c) SDRs; Region: SDR_c; cd05233
362242005529	NAD(P) binding site [chemical binding]; other site
362242005530	active site
362242005531	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242005532	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242005533	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242005534	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
362242005535	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
362242005536	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
362242005537	active site
362242005538	Dienelactone hydrolase family; Region: DLH; pfam01738
362242005539	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
362242005540	thymidylate synthase; Reviewed; Region: thyA; PRK01827
362242005541	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
362242005542	dimerization interface [polypeptide binding]; other site
362242005543	active site
362242005544	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
362242005545	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
362242005546	folate binding site [chemical binding]; other site
362242005547	NADP+ binding site [chemical binding]; other site
362242005548	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214
362242005549	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
362242005550	FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847
362242005551	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
362242005552	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
362242005553	dimer interface [polypeptide binding]; other site
362242005554	active site
362242005555	catalytic residue [active]
362242005556	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242005557	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242005558	Domain of unknown function (DUF385); Region: DUF385; cl04387
362242005559	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
362242005560	metal binding site 2 [ion binding]; metal-binding site
362242005561	putative DNA binding helix; other site
362242005562	metal binding site 1 [ion binding]; metal-binding site
362242005563	dimer interface [polypeptide binding]; other site
362242005564	structural Zn2+ binding site [ion binding]; other site
362242005565	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
362242005566	Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196
362242005567	heme binding site [chemical binding]; other site
362242005568	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
362242005569	BCCT family transporter; Region: BCCT; pfam02028
362242005570	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242005571	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242005572	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242005573	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242005574	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242005575	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242005576	Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969
362242005577	putative catalytic residue [active]
362242005578	Nitroreductase family; Region: Nitroreductase; pfam00881
362242005579	FMN binding site [chemical binding]; other site
362242005580	dimer interface [polypeptide binding]; other site
362242005581	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
362242005582	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
362242005583	active site
362242005584	ATP binding site [chemical binding]; other site
362242005585	substrate binding site [chemical binding]; other site
362242005586	activation loop (A-loop); other site
362242005587	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
362242005588	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
362242005589	ligand binding site [chemical binding]; other site
362242005590	flexible hinge region; other site
362242005591	putative septicolysin, cholesterol-dependent cytolysin family and related proteins; Region: septicolysin_like; cd12208
362242005592	oligomer interface [polypeptide binding]; other site
362242005594	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
362242005595	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
362242005596	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267
362242005597	putative NAD(P) binding site [chemical binding]; other site
362242005598	Cellulose binding domain; Region: CBM_2; pfam00553
362242005599	Muconolactone delta-isomerase; Region: MIase; cl01992
362242005600	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818
362242005601	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
362242005602	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
362242005603	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
362242005604	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242005605	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242005606	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242005607	Transposase, Mutator family; Region: Transposase_mut; pfam00872
362242005608	MULE transposase domain; Region: MULE; pfam10551
362242005609	BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418
362242005610	active site
362242005611	Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970
362242005612	putative catalytic residues [active]
362242005613	Hemerythrin-like domain; Region: Hr-like; cd12108
362242005614	Fe binding site [ion binding]; other site
362242005616	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242005617	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242005618	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
362242005619	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
362242005620	putative dimer interface [polypeptide binding]; other site
362242005621	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
362242005622	active site
362242005623	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
362242005624	Ligand Binding Site [chemical binding]; other site
362242005625	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
362242005626	Ligand Binding Site [chemical binding]; other site
362242005627	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
362242005628	Ligand Binding Site [chemical binding]; other site
362242005629	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
362242005630	Ligand Binding Site [chemical binding]; other site
362242005631	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
362242005632	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
362242005633	DNA binding residues [nucleotide binding]
362242005634	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
362242005635	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
362242005636	OsmC-like protein; Region: OsmC; pfam02566
362242005637	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842
362242005638	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
362242005639	PPE family; Region: PPE; pfam00823
362242005640	PE family; Region: PE; pfam00934
362242005641	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
362242005642	PPE family; Region: PPE; pfam00823
362242005643	Protein of unknown function (DUF3097); Region: DUF3097; pfam11296
362242005644	PE family; Region: PE; pfam00934
362242005645	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
362242005646	ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207
362242005647	nucleophile elbow; other site
362242005648	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
362242005649	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
362242005650	Walker A/P-loop; other site
362242005651	ATP binding site [chemical binding]; other site
362242005652	Q-loop/lid; other site
362242005653	ABC transporter signature motif; other site
362242005654	Walker B; other site
362242005655	D-loop; other site
362242005656	H-loop/switch region; other site
362242005657	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
362242005658	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
362242005659	dimer interface [polypeptide binding]; other site
362242005660	conserved gate region; other site
362242005661	putative PBP binding loops; other site
362242005662	ABC-ATPase subunit interface; other site
362242005663	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
362242005664	dimer interface [polypeptide binding]; other site
362242005665	conserved gate region; other site
362242005666	putative PBP binding loops; other site
362242005667	ABC-ATPase subunit interface; other site
362242005668	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
362242005669	Isochorismatase family; Region: Isochorismatase; pfam00857
362242005670	catalytic triad [active]
362242005671	metal binding site [ion binding]; metal-binding site
362242005672	conserved cis-peptide bond; other site
362242005673	Predicted membrane protein [Function unknown]; Region: COG2259
362242005674	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
362242005675	AAA domain; Region: AAA_33; pfam13671
362242005676	ATP-binding site [chemical binding]; other site
362242005677	Gluconate-6-phosphate binding site [chemical binding]; other site
362242005678	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
362242005679	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
362242005680	substrate binding pocket [chemical binding]; other site
362242005681	catalytic triad [active]
362242005682	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
362242005683	Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544
362242005684	hypothetical protein; Provisional; Region: PRK05865
362242005685	UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240
362242005686	putative NAD(P) binding site [chemical binding]; other site
362242005687	active site
362242005688	putative substrate binding site [chemical binding]; other site
362242005689	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
362242005690	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
362242005691	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
362242005692	active site
362242005693	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
362242005694	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
362242005695	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
362242005696	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
362242005697	Enoylreductase; Region: PKS_ER; smart00829
362242005698	NAD(P) binding site [chemical binding]; other site
362242005699	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
362242005700	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956
362242005701	putative NADP binding site [chemical binding]; other site
362242005702	active site
362242005703	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
362242005704	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
362242005705	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
362242005706	active site
362242005707	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
362242005708	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
362242005709	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
362242005710	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
362242005711	Enoylreductase; Region: PKS_ER; smart00829
362242005712	NAD(P) binding site [chemical binding]; other site
362242005713	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956
362242005714	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
362242005715	putative NADP binding site [chemical binding]; other site
362242005716	active site
362242005717	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
362242005718	Domain of unknown function (DUF4109); Region: DUF4109; pfam13397
362242005719	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
362242005720	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
362242005721	Ligand binding site; other site
362242005722	Putative Catalytic site; other site
362242005723	DXD motif; other site
362242005724	Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815
362242005725	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
362242005726	putative active site [active]
362242005727	catalytic triad [active]
362242005728	putative dimer interface [polypeptide binding]; other site
362242005729	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
362242005730	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
362242005731	active site
362242005732	phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463
362242005733	Dienelactone hydrolase family; Region: DLH; pfam01738
362242005734	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
362242005735	Domain of unknown function (DUF389); Region: DUF389; pfam04087
362242005736	Uncharacterized conserved protein [Function unknown]; Region: COG2966
362242005737	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
362242005738	Uncharacterized conserved protein [Function unknown]; Region: COG3610
362242005739	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
362242005740	conserved cys residue [active]
362242005741	PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666
362242005742	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989
362242005743	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
362242005744	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
362242005745	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
362242005746	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
362242005747	Moco binding site; other site
362242005748	metal coordination site [ion binding]; other site
362242005749	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242005750	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242005751	short chain dehydrogenase; Provisional; Region: PRK07825
362242005752	classical (c) SDRs; Region: SDR_c; cd05233
362242005753	NAD(P) binding site [chemical binding]; other site
362242005754	active site
362242005755	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995
362242005756	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
362242005757	cyclase homology domain; Region: CHD; cd07302
362242005758	nucleotidyl binding site; other site
362242005759	metal binding site [ion binding]; metal-binding site
362242005760	dimer interface [polypeptide binding]; other site
362242005761	precorrin-3B synthase; Region: CobG; TIGR02435
362242005762	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
362242005763	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
362242005764	precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285
362242005765	Precorrin-8X methylmutase; Region: CbiC; pfam02570
362242005766	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
362242005767	active site
362242005768	SAM binding site [chemical binding]; other site
362242005769	homodimer interface [polypeptide binding]; other site
362242005770	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
362242005771	active site
362242005772	SAM binding site [chemical binding]; other site
362242005773	homodimer interface [polypeptide binding]; other site
362242005774	Methyltransferase domain; Region: Methyltransf_31; pfam13847
362242005775	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
362242005776	S-adenosylmethionine binding site [chemical binding]; other site
362242005777	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126
362242005778	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
362242005779	Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367
362242005780	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
362242005781	RNA polymerase sigma factor SigC; Reviewed; Region: PRK09649
362242005782	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
362242005783	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
362242005784	DNA binding residues [nucleotide binding]
362242005785	cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057
362242005786	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
362242005787	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
362242005788	active site
362242005789	SAM binding site [chemical binding]; other site
362242005790	homodimer interface [polypeptide binding]; other site
362242005791	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
362242005792	active site
362242005793	putative homodimer interface [polypeptide binding]; other site
362242005794	SAM binding site [chemical binding]; other site
362242005795	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
362242005796	precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; Region: CbiT; TIGR02469
362242005797	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
362242005798	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
362242005799	NAD(P) binding site [chemical binding]; other site
362242005800	active site
362242005801	PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618
362242005802	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242005803	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242005804	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242005805	chromosome segregation protein; Provisional; Region: PRK02224
362242005806	putative transposase OrfB; Reviewed; Region: PHA02517
362242005809	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913
362242005810	P-loop containing region of AAA domain; Region: AAA_29; cl17516
362242005811	Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558
362242005812	Domain of unknown function (DUF4194); Region: DUF4194; pfam13835
362242005813	Protein of unknown function (DUF3375); Region: DUF3375; pfam11855
362242005814	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
362242005815	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
362242005816	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
362242005817	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
362242005818	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279
362242005819	active site
362242005820	5'-3' exonuclease; Region: 53EXOc; smart00475
362242005821	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
362242005822	active site
362242005823	metal binding site 1 [ion binding]; metal-binding site
362242005824	putative 5' ssDNA interaction site; other site
362242005825	metal binding site 3; metal-binding site
362242005826	metal binding site 2 [ion binding]; metal-binding site
362242005827	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
362242005828	putative DNA binding site [nucleotide binding]; other site
362242005829	putative metal binding site [ion binding]; other site
362242005830	Domain of unknown function (DUF4333); Region: DUF4333; pfam14230
362242005831	Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581
362242005832	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
362242005833	ATP binding site [chemical binding]; other site
362242005834	putative Mg++ binding site [ion binding]; other site
362242005835	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
362242005836	nucleotide binding region [chemical binding]; other site
362242005837	ATP-binding site [chemical binding]; other site
362242005838	DSHCT (NUC185) domain; Region: DSHCT; pfam08148
362242005839	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
362242005840	twin arginine translocase protein A; Provisional; Region: tatA; PRK00575
362242005841	Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826
362242005842	Predicted transcriptional regulator [Transcription]; Region: COG2378
362242005843	WYL domain; Region: WYL; pfam13280
362242005844	Predicted transcriptional regulator [Transcription]; Region: COG2378
362242005845	WYL domain; Region: WYL; pfam13280
362242005846	proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686
362242005847	proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691
362242005848	proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906
362242005849	active site
362242005850	proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690
362242005851	proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906
362242005852	active site
362242005853	Pup-like protein; Region: Pup; cl05289
362242005854	proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688
362242005855	proteasome ATPase; Region: pup_AAA; TIGR03689
362242005856	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
362242005857	Walker A motif; other site
362242005858	ATP binding site [chemical binding]; other site
362242005859	Walker B motif; other site
362242005860	arginine finger; other site
362242005861	Protein of unknown function (DUF503); Region: DUF503; cl00669
362242005862	tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519
362242005863	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
362242005864	RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887
362242005865	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
362242005866	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242005867	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242005868	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242005870	Transposase, Mutator family; Region: Transposase_mut; pfam00872
362242005871	MULE transposase domain; Region: MULE; pfam10551
362242005872	Transposase, Mutator family; Region: Transposase_mut; pfam00872
362242005873	MULE transposase domain; Region: MULE; pfam10551
362242005874	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242005875	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242005876	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242005877	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
362242005878	ATP phosphoribosyltransferase; Region: hisG; TIGR00070
362242005879	ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455
362242005880	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547
362242005881	homodimer interface [polypeptide binding]; other site
362242005882	putative metal binding site [ion binding]; other site
362242005883	PE family; Region: PE; pfam00934
362242005884	PAC2 family; Region: PAC2; pfam09754
362242005885	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
362242005886	hypothetical protein; Provisional; Region: PRK07236
362242005887	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
362242005888	short chain dehydrogenase; Provisional; Region: PRK05872
362242005889	classical (c) SDRs; Region: SDR_c; cd05233
362242005890	NAD(P) binding site [chemical binding]; other site
362242005891	active site
362242005892	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
362242005893	cysteinyl-tRNA synthetase; Provisional; Region: PRK12418
362242005894	active site
362242005895	HIGH motif; other site
362242005896	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
362242005897	active site
362242005898	KMSKS motif; other site
362242005899	Anticodon-binding domain of cysteinyl tRNA synthetases and domain found in MshC; Region: Anticodon_Ia_Cys_like; cd07955
362242005900	putative tRNA binding surface [nucleotide binding]; other site
362242005901	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
362242005902	Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099
362242005903	NAD(P) binding site [chemical binding]; other site
362242005904	catalytic residues [active]
362242005905	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
362242005906	active site
362242005907	conserved hypothetical protein; Region: TIGR03843
362242005908	Protein of unknown function (DUF3090); Region: DUF3090; pfam11290
362242005909	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
362242005910	catalytic core [active]
362242005911	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554
362242005912	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
362242005913	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
362242005914	quinone interaction residues [chemical binding]; other site
362242005915	active site
362242005916	catalytic residues [active]
362242005917	FMN binding site [chemical binding]; other site
362242005918	substrate binding site [chemical binding]; other site
362242005919	Domain of unknown function (DUF222); Region: DUF222; pfam02720
362242005920	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
362242005921	active site
362242005922	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
362242005923	substrate binding site [chemical binding]; other site
362242005924	hypothetical protein; Provisional; Region: PRK07906
362242005925	M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675
362242005926	putative metal binding site [ion binding]; other site
362242005927	Methyltransferase domain; Region: Methyltransf_31; pfam13847
362242005928	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
362242005929	S-adenosylmethionine binding site [chemical binding]; other site
362242005930	MbtH-like protein; Region: MbtH; pfam03621
362242005931	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
362242005932	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242005933	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242005934	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242005935	Predicted transcriptional regulators [Transcription]; Region: COG1695
362242005936	Transcriptional regulator PadR-like family; Region: PadR; cl17335
362242005937	Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468
362242005938	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
362242005939	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
362242005940	active site
362242005941	MspA; Region: MspA; pfam09203
362242005942	PE family; Region: PE; pfam00934
362242005943	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
362242005944	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
362242005945	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
362242005946	TPR motif; other site
362242005947	binding surface
362242005948	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
362242005949	TPR motif; other site
362242005950	TPR repeat; Region: TPR_11; pfam13414
362242005951	binding surface
362242005952	ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464
362242005953	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
362242005954	ATP binding site [chemical binding]; other site
362242005955	Walker B motif; other site
362242005956	arginine finger; other site
362242005957	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242005958	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242005959	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242005960	Transposase, Mutator family; Region: Transposase_mut; pfam00872
362242005961	MULE transposase domain; Region: MULE; pfam10551
362242005962	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242005963	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242005964	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242005965	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
362242005966	SmpB-tmRNA interface; other site
362242005967	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
362242005968	FtsX-like permease family; Region: FtsX; pfam02687
362242005969	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
362242005970	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
362242005971	Walker A/P-loop; other site
362242005972	ATP binding site [chemical binding]; other site
362242005973	Q-loop/lid; other site
362242005974	ABC transporter signature motif; other site
362242005975	Walker B; other site
362242005976	D-loop; other site
362242005977	H-loop/switch region; other site
362242005978	Mechanosensitive ion channel; Region: MS_channel; pfam00924
362242005979	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
362242005980	peptide chain release factor 2; Validated; Region: prfB; PRK00578
362242005981	This domain is found in peptide chain release factors; Region: PCRF; smart00937
362242005982	RF-1 domain; Region: RF-1; pfam00472
362242005983	ferredoxin-NADP+ reductase; Region: PLN02852
362242005984	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
362242005985	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242005986	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242005987	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242005988	Domain of unknown function (DUF222); Region: DUF222; pfam02720
362242005989	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
362242005990	dimer interface [polypeptide binding]; other site
362242005991	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900
362242005992	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
362242005993	heme-binding site [chemical binding]; other site
362242005994	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
362242005995	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
362242005996	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
362242005997	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
362242005998	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
362242005999	GAF domain; Region: GAF_3; pfam13492
362242006000	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
362242006001	Histidine kinase; Region: HisKA_3; pfam07730
362242006002	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
362242006003	ATP binding site [chemical binding]; other site
362242006004	Mg2+ binding site [ion binding]; other site
362242006005	G-X-G motif; other site
362242006006	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
362242006007	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
362242006008	active site
362242006009	phosphorylation site [posttranslational modification]
362242006010	intermolecular recognition site; other site
362242006011	dimerization interface [polypeptide binding]; other site
362242006012	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
362242006013	DNA binding residues [nucleotide binding]
362242006014	dimerization interface [polypeptide binding]; other site
362242006015	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
362242006016	Ligand Binding Site [chemical binding]; other site
362242006017	Transposase, Mutator family; Region: Transposase_mut; pfam00872
362242006018	MULE transposase domain; Region: MULE; pfam10551
362242006019	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242006020	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242006021	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242006022	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
362242006023	PPE family; Region: PPE; pfam00823
362242006024	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
362242006025	PPE family; Region: PPE; pfam00823
362242006026	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
362242006027	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate,  or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
362242006028	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
362242006029	active site
362242006030	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
362242006031	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
362242006032	active site
362242006033	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
362242006034	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
362242006035	active site
362242006036	acetolactate synthase; Reviewed; Region: PRK08617
362242006037	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
362242006038	PYR/PP interface [polypeptide binding]; other site
362242006039	dimer interface [polypeptide binding]; other site
362242006040	TPP binding site [chemical binding]; other site
362242006041	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
362242006042	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
362242006043	TPP-binding site [chemical binding]; other site
362242006044	Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306
362242006045	4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195
362242006046	4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943
362242006047	active site
362242006048	catalytic residues [active]
362242006049	metal binding site [ion binding]; metal-binding site
362242006050	DmpG-like communication domain; Region: DmpG_comm; pfam07836
362242006051	acetaldehyde dehydrogenase; Validated; Region: PRK08300
362242006052	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
362242006053	Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290
362242006054	Amidohydrolase; Region: Amidohydro_2; pfam04909
362242006055	Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288
362242006056	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
362242006057	NADP binding site [chemical binding]; other site
362242006058	dimer interface [polypeptide binding]; other site
362242006059	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
362242006060	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
362242006061	NAD(P) binding site [chemical binding]; other site
362242006062	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
362242006063	PPE family; Region: PPE; pfam00823
362242006064	PE-PPE domain; Region: PE-PPE; pfam08237
362242006065	Transposase, Mutator family; Region: Transposase_mut; pfam00872
362242006066	MULE transposase domain; Region: MULE; pfam10551
362242006067	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242006068	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242006069	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242006070	homogentisate 1,2-dioxygenase; Region: HgmA; cl17306
362242006071	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
362242006072	CoA-transferase family III; Region: CoA_transf_3; pfam02515
362242006073	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
362242006074	active site
362242006075	catalytic residues [active]
362242006076	metal binding site [ion binding]; metal-binding site
362242006077	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
362242006078	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
362242006079	Phosphotransferase enzyme family; Region: APH; pfam01636
362242006080	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
362242006081	putative active site [active]
362242006082	putative substrate binding site [chemical binding]; other site
362242006083	ATP binding site [chemical binding]; other site
362242006084	SnoaL-like domain; Region: SnoaL_2; pfam12680
362242006085	YceI-like domain; Region: YceI; pfam04264
362242006086	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
362242006087	active site
362242006088	phosphorylation site [posttranslational modification]
362242006089	intermolecular recognition site; other site
362242006090	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242006091	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242006092	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242006093	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242006094	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242006095	NADH dehydrogenase subunit A; Validated; Region: PRK07928
362242006096	NADH dehydrogenase subunit B; Validated; Region: PRK06411
362242006097	NADH dehydrogenase subunit C; Provisional; Region: PRK07785
362242006098	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
362242006099	NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962
362242006100	NADH dehydrogenase subunit D; Validated; Region: PRK06075
362242006101	NADH dehydrogenase subunit E; Validated; Region: PRK07539
362242006102	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
362242006103	putative dimer interface [polypeptide binding]; other site
362242006104	[2Fe-2S] cluster binding site [ion binding]; other site
362242006105	NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959
362242006106	SLBB domain; Region: SLBB; pfam10531
362242006107	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
362242006108	NADH dehydrogenase subunit G; Validated; Region: PRK07860
362242006109	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
362242006110	catalytic loop [active]
362242006111	iron binding site [ion binding]; other site
362242006112	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
362242006113	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
362242006114	molybdopterin cofactor binding site; other site
362242006115	MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788
362242006116	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
362242006117	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
362242006118	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
362242006119	4Fe-4S binding domain; Region: Fer4; pfam00037
362242006120	4Fe-4S binding domain; Region: Fer4; pfam00037
362242006121	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
362242006122	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
362242006123	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
362242006124	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
362242006125	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
362242006126	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
362242006127	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
362242006128	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
362242006129	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
362242006130	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242006131	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242006132	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242006133	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
362242006134	Protein of unknown function DUF58; Region: DUF58; pfam01882
362242006135	MoxR-like ATPases [General function prediction only]; Region: COG0714
362242006136	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
362242006137	Walker A motif; other site
362242006138	ATP binding site [chemical binding]; other site
362242006139	Walker B motif; other site
362242006140	arginine finger; other site
362242006141	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
362242006142	classical (c) SDRs; Region: SDR_c; cd05233
362242006143	NAD(P) binding site [chemical binding]; other site
362242006144	active site
362242006145	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
362242006146	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
362242006147	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
362242006148	putative active site [active]
362242006149	putative substrate binding site [chemical binding]; other site
362242006150	ATP binding site [chemical binding]; other site
362242006151	PE family; Region: PE; pfam00934
362242006153	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
362242006154	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
362242006155	Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231
362242006156	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
362242006157	hydroxyglutarate oxidase; Provisional; Region: PRK11728
362242006158	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
362242006159	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
362242006160	probable polyamine oxidase; Region: PLN02268
362242006161	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
362242006162	SnoaL-like domain; Region: SnoaL_2; pfam12680
362242006163	glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208
362242006164	Protein of unknown function (DUF2652); Region: DUF2652; pfam10851
362242006165	citrate synthase; Provisional; Region: PRK14033
362242006166	Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416
362242006167	oxalacetate binding site [chemical binding]; other site
362242006168	citrylCoA binding site [chemical binding]; other site
362242006169	coenzyme A binding site [chemical binding]; other site
362242006170	catalytic triad [active]
362242006171	Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079
362242006172	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
362242006173	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
362242006174	non-specific DNA binding site [nucleotide binding]; other site
362242006175	salt bridge; other site
362242006176	sequence-specific DNA binding site [nucleotide binding]; other site
362242006177	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
362242006178	Domain of unknown function (DUF955); Region: DUF955; pfam06114
362242006179	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
362242006180	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
362242006181	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
362242006182	SnoaL-like domain; Region: SnoaL_4; pfam13577
362242006183	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
362242006184	Sulfatase; Region: Sulfatase; pfam00884
362242006185	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
362242006186	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
362242006187	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
362242006188	hypothetical protein; Validated; Region: PRK00068
362242006189	Uncharacterized conserved protein [Function unknown]; Region: COG1615
362242006190	Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480
362242006191	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
362242006192	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
362242006193	Uncharacterized conserved protein [Function unknown]; Region: COG5282
362242006194	uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883
362242006195	bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882
362242006196	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
362242006197	ABC1 family; Region: ABC1; pfam03109
362242006198	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
362242006199	active site
362242006200	ATP binding site [chemical binding]; other site
362242006201	Transcription factor WhiB; Region: Whib; pfam02467
362242006202	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
362242006203	Part of AAA domain; Region: AAA_19; pfam13245
362242006204	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
362242006205	Family description; Region: UvrD_C_2; pfam13538
362242006206	HRDC domain; Region: HRDC; pfam00570
362242006207	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
362242006208	catalytic residues [active]
362242006209	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
362242006210	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242006211	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242006212	Transposase, Mutator family; Region: Transposase_mut; pfam00872
362242006213	MULE transposase domain; Region: MULE; pfam10551
362242006214	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242006215	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242006216	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242006217	PknH-like extracellular domain; Region: PknH_C; pfam14032
362242006218	NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241
362242006219	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
362242006220	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
362242006221	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
362242006222	putative NADH binding site [chemical binding]; other site
362242006223	putative active site [active]
362242006224	nudix motif; other site
362242006225	putative metal binding site [ion binding]; other site
362242006226	Ion channel; Region: Ion_trans_2; pfam07885
362242006227	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
362242006228	TrkA-N domain; Region: TrkA_N; pfam02254
362242006229	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
362242006230	Part of AAA domain; Region: AAA_19; pfam13245
362242006231	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
362242006232	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
362242006233	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
362242006234	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
362242006235	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
362242006236	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
362242006237	catalytic site [active]
362242006238	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
362242006239	active site
362242006240	DNA binding site [nucleotide binding]
362242006241	TIGR02569 family protein; Region: TIGR02569_actnb
362242006242	molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878
362242006243	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
362242006244	ATP binding site [chemical binding]; other site
362242006245	substrate interface [chemical binding]; other site
362242006246	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
362242006247	active site residue [active]
362242006248	Protein of unknown function (DUF3152); Region: DUF3152; pfam11350
362242006249	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
362242006250	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
362242006251	Protein of unknown function (DUF3107); Region: DUF3107; pfam11305
362242006252	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
362242006253	dinuclear metal binding motif [ion binding]; other site
362242006254	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
362242006255	DEAD-like helicases superfamily; Region: DEXDc; smart00487
362242006256	ATP binding site [chemical binding]; other site
362242006257	Mg++ binding site [ion binding]; other site
362242006258	motif III; other site
362242006259	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
362242006260	nucleotide binding region [chemical binding]; other site
362242006261	ATP-binding site [chemical binding]; other site
362242006262	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
362242006263	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
362242006264	P-loop; other site
362242006265	Magnesium ion binding site [ion binding]; other site
362242006266	transport-energizing ATPase, TRC40/GET3/ArsA family; Region: GET3_arsA_TRC40; TIGR00345
362242006267	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
362242006268	Magnesium ion binding site [ion binding]; other site
362242006269	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
362242006270	catalytic core [active]
362242006271	Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169
362242006272	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
362242006273	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
362242006274	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
362242006275	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
362242006276	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
362242006277	Transcription factor WhiB; Region: Whib; pfam02467
362242006278	Signal transduction histidine kinase; Region: H_kinase_N; pfam12282
362242006279	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
362242006280	Histidine kinase; Region: HisKA_2; pfam07568
362242006281	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
362242006282	ATP binding site [chemical binding]; other site
362242006283	Mg2+ binding site [ion binding]; other site
362242006284	G-X-G motif; other site
362242006285	Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511
362242006286	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
362242006287	carboxyltransferase (CT) interaction site; other site
362242006288	biotinylation site [posttranslational modification]; other site
362242006289	anti-sigma factor, TIGR02949 family; Region: anti_SigH_actin
362242006290	RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino
362242006291	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
362242006292	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
362242006293	DNA binding residues [nucleotide binding]
362242006294	short chain dehydrogenase; Provisional; Region: PRK08278
362242006295	human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762
362242006296	NAD(P) binding site [chemical binding]; other site
362242006297	homodimer interface [polypeptide binding]; other site
362242006298	active site
362242006299	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022
362242006300	putative deacylase active site [active]
362242006301	YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575
362242006302	Protein of unknown function (DUF2580); Region: DUF2580; pfam10824
362242006303	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
362242006304	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
362242006305	DNA binding residues [nucleotide binding]
362242006306	dimerization interface [polypeptide binding]; other site
362242006307	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
362242006308	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
362242006309	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
362242006310	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
362242006311	Uncharacterized conserved protein [Function unknown]; Region: COG2135
362242006312	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
362242006313	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
362242006314	hinge; other site
362242006315	active site
362242006316	Predicted GTPases [General function prediction only]; Region: COG1162
362242006317	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
362242006318	GTPase/Zn-binding domain interface [polypeptide binding]; other site
362242006319	GTP/Mg2+ binding site [chemical binding]; other site
362242006320	G4 box; other site
362242006321	G5 box; other site
362242006322	G1 box; other site
362242006323	Switch I region; other site
362242006324	G2 box; other site
362242006325	G3 box; other site
362242006326	Switch II region; other site
362242006327	Predicted transcriptional regulators [Transcription]; Region: COG1733
362242006328	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
362242006329	acetyl-CoA acetyltransferase; Provisional; Region: PRK07801
362242006330	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
362242006331	dimer interface [polypeptide binding]; other site
362242006332	active site
362242006333	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
362242006334	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
362242006335	putative di-iron ligands [ion binding]; other site
362242006336	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
362242006337	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
362242006338	putative di-iron ligands [ion binding]; other site
362242006339	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216
362242006340	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
362242006341	FAD binding pocket [chemical binding]; other site
362242006342	FAD binding motif [chemical binding]; other site
362242006343	phosphate binding motif [ion binding]; other site
362242006344	beta-alpha-beta structure motif; other site
362242006345	NAD binding pocket [chemical binding]; other site
362242006346	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
362242006347	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
362242006348	catalytic loop [active]
362242006349	iron binding site [ion binding]; other site
362242006350	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
362242006351	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
362242006352	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
362242006353	Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490
362242006354	TrkA-C domain; Region: TrkA_C; pfam02080
362242006355	Phospholipid methyltransferase; Region: PEMT; cl17370
362242006356	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
362242006357	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
362242006358	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
362242006359	30S subunit binding site; other site
362242006360	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
362242006361	lipoprotein LpqB; Provisional; Region: PRK13616
362242006362	Sporulation and spore germination; Region: Germane; pfam10646
362242006363	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
362242006364	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
362242006365	dimerization interface [polypeptide binding]; other site
362242006366	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
362242006367	dimer interface [polypeptide binding]; other site
362242006368	phosphorylation site [posttranslational modification]
362242006369	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
362242006370	ATP binding site [chemical binding]; other site
362242006371	Mg2+ binding site [ion binding]; other site
362242006372	G-X-G motif; other site
362242006373	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
362242006374	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
362242006375	active site
362242006376	phosphorylation site [posttranslational modification]
362242006377	intermolecular recognition site; other site
362242006378	dimerization interface [polypeptide binding]; other site
362242006379	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
362242006380	DNA binding site [nucleotide binding]
362242006381	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
362242006382	Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125
362242006383	TMP-binding site; other site
362242006384	ATP-binding site [chemical binding]; other site
362242006385	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242006386	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242006387	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242006388	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242006389	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242006390	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242006392	Adenosylhomocysteinase; Provisional; Region: PTZ00075
362242006393	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
362242006394	homotetramer interface [polypeptide binding]; other site
362242006395	ligand binding site [chemical binding]; other site
362242006396	catalytic site [active]
362242006397	NAD binding site [chemical binding]; other site
362242006398	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
362242006399	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
362242006400	Rubredoxin [Energy production and conversion]; Region: COG1773
362242006401	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
362242006402	iron binding site [ion binding]; other site
362242006403	Rubredoxin [Energy production and conversion]; Region: COG1773
362242006404	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
362242006405	iron binding site [ion binding]; other site
362242006406	amino acid transporter; Region: 2A0306; TIGR00909
362242006407	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
362242006408	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
362242006409	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
362242006410	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
362242006411	mannose-6-phosphate isomerase; Provisional; Region: PRK15131
362242006412	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
362242006413	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
362242006414	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
362242006415	phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542
362242006416	active site
362242006417	substrate binding site [chemical binding]; other site
362242006418	metal binding site [ion binding]; metal-binding site
362242006419	Protein of unknown function (DUF3499); Region: DUF3499; pfam12005
362242006420	Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954
362242006421	Transcription factor WhiB; Region: Whib; pfam02467
362242006422	LPPG:FO 2-phospho-L-lactate transferase; Provisional; Region: PRK13606
362242006423	Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933
362242006424	dimer interface [polypeptide binding]; other site
362242006425	phosphate binding site [ion binding]; other site
362242006426	F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294
362242006427	F420-0:gamma-glutamyl ligase; Region: F420_cofE; TIGR01916
362242006428	F420 biosynthesis protein FbiB, C-terminal domain; Region: F420_FbiB_CTERM; TIGR03553
362242006429	FMN binding site [chemical binding]; other site
362242006430	dimer interface [polypeptide binding]; other site
362242006431	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827
362242006432	Methyltransferase domain; Region: Methyltransf_26; pfam13659
362242006433	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674
362242006434	nudix motif; other site
362242006435	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
362242006436	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
362242006437	active site
362242006438	Substrate binding site; other site
362242006439	Mg++ binding site; other site
362242006440	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
362242006441	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
362242006442	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
362242006443	Probable Catalytic site; other site
362242006444	metal-binding site
362242006445	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
362242006446	NADP binding site [chemical binding]; other site
362242006447	active site
362242006448	putative substrate binding site [chemical binding]; other site
362242006449	Transcriptional regulator [Transcription]; Region: LytR; COG1316
362242006450	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
362242006451	TIGR03089 family protein; Region: TIGR03089
362242006452	Protein of unknown function (DUF1490); Region: DUF1490; pfam07371
362242006453	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
362242006454	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
362242006455	Soluble P-type ATPase [General function prediction only]; Region: COG4087
362242006456	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
362242006457	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
362242006458	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
362242006459	CoA-transferase family III; Region: CoA_transf_3; pfam02515
362242006460	Response regulator receiver domain; Region: Response_reg; pfam00072
362242006461	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
362242006462	active site
362242006463	phosphorylation site [posttranslational modification]
362242006464	intermolecular recognition site; other site
362242006465	dimerization interface [polypeptide binding]; other site
362242006466	CHASE3 domain; Region: CHASE3; pfam05227
362242006467	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
362242006468	dimer interface [polypeptide binding]; other site
362242006469	phosphorylation site [posttranslational modification]
362242006470	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
362242006471	ATP binding site [chemical binding]; other site
362242006472	Mg2+ binding site [ion binding]; other site
362242006473	G-X-G motif; other site
362242006474	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
362242006475	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
362242006476	active site
362242006477	phosphorylation site [posttranslational modification]
362242006478	intermolecular recognition site; other site
362242006479	dimerization interface [polypeptide binding]; other site
362242006480	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
362242006481	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
362242006482	Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158
362242006483	FAD binding site [chemical binding]; other site
362242006484	homotetramer interface [polypeptide binding]; other site
362242006485	substrate binding pocket [chemical binding]; other site
362242006486	catalytic base [active]
362242006487	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
362242006488	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
362242006489	ATP-grasp domain; Region: ATP-grasp; pfam02222
362242006490	Predicted membrane protein [Function unknown]; Region: COG2246
362242006491	GtrA-like protein; Region: GtrA; pfam04138
362242006492	Bacterial PH domain; Region: DUF304; pfam03703
362242006493	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
362242006494	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
362242006495	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
362242006496	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
362242006497	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
362242006498	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
362242006499	Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822
362242006500	Maf-like protein; Region: Maf; pfam02545
362242006501	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
362242006502	active site
362242006503	dimer interface [polypeptide binding]; other site
362242006504	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
362242006505	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
362242006506	active site residue [active]
362242006507	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
362242006508	active site residue [active]
362242006509	Fe-S metabolism associated domain; Region: SufE; cl00951
362242006510	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
362242006511	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
362242006512	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
362242006513	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
362242006514	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
362242006515	carboxyltransferase (CT) interaction site; other site
362242006516	biotinylation site [posttranslational modification]; other site
362242006517	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
362242006518	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
362242006519	active site
362242006520	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
362242006521	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
362242006522	acyl-activating enzyme (AAE) consensus motif; other site
362242006523	AMP binding site [chemical binding]; other site
362242006524	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
362242006525	Condensation domain; Region: Condensation; pfam00668
362242006526	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
362242006527	Condensation domain; Region: Condensation; pfam00668
362242006528	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
362242006529	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
362242006530	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
362242006531	acyl-activating enzyme (AAE) consensus motif; other site
362242006532	AMP binding site [chemical binding]; other site
362242006533	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
362242006534	Condensation domain; Region: Condensation; pfam00668
362242006535	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
362242006536	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
362242006537	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
362242006538	WHG domain; Region: WHG; pfam13305
362242006539	RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122
362242006540	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
362242006541	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
362242006542	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
362242006543	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
362242006544	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
362242006545	L-lysine aminotransferase; Provisional; Region: PRK08297
362242006546	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
362242006547	inhibitor-cofactor binding pocket; inhibition site
362242006548	pyridoxal 5'-phosphate binding site [chemical binding]; other site
362242006549	catalytic residue [active]
362242006550	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
362242006551	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
362242006552	AsnC family; Region: AsnC_trans_reg; pfam01037
362242006553	Domain of unknown function (DUF1338); Region: DUF1338; pfam07063
362242006554	NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130
362242006555	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
362242006556	tetrameric interface [polypeptide binding]; other site
362242006557	NAD binding site [chemical binding]; other site
362242006558	catalytic residues [active]
362242006559	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
362242006560	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
362242006561	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
362242006562	N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971
362242006563	putative DNA binding site [nucleotide binding]; other site
362242006564	catalytic residue [active]
362242006565	putative H2TH interface [polypeptide binding]; other site
362242006566	putative catalytic residues [active]
362242006567	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
362242006568	Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509
362242006569	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242006570	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242006571	PBP superfamily domain; Region: PBP_like_2; cl17296
362242006572	Protein of unknown function (DUF732); Region: DUF732; pfam05305
362242006573	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
362242006574	Sulfatase; Region: Sulfatase; pfam00884
362242006575	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
362242006576	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
362242006577	active site
362242006578	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
362242006579	PhoU domain; Region: PhoU; pfam01895
362242006580	PhoU domain; Region: PhoU; pfam01895
362242006581	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
362242006582	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
362242006583	active site
362242006584	FMN binding site [chemical binding]; other site
362242006585	substrate binding site [chemical binding]; other site
362242006586	3Fe-4S cluster binding site [ion binding]; other site
362242006587	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
362242006588	flavoprotein disulfide reductase; Reviewed; Region: PRK07845
362242006589	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
362242006590	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
362242006591	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
362242006592	putative active site pocket [active]
362242006593	dimerization interface [polypeptide binding]; other site
362242006594	putative catalytic residue [active]
362242006595	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
362242006596	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014
362242006597	metal binding site [ion binding]; metal-binding site
362242006598	putative dimer interface [polypeptide binding]; other site
362242006599	M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672
362242006600	amidohydrolase; Region: amidohydrolases; TIGR01891
362242006601	metal binding site [ion binding]; metal-binding site
362242006602	purine nucleoside phosphorylase; Provisional; Region: PRK08202
362242006603	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
362242006604	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
362242006605	active site
362242006606	substrate binding site [chemical binding]; other site
362242006607	metal binding site [ion binding]; metal-binding site
362242006608	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
362242006609	active site
362242006610	Phosphoesterase family; Region: Phosphoesterase; pfam04185
362242006611	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
362242006612	Domain of unknown function (DUF222); Region: DUF222; pfam02720
362242006613	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
362242006614	active site
362242006615	uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555
362242006616	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
362242006617	Na binding site [ion binding]; other site
362242006618	putative substrate binding site [chemical binding]; other site
362242006619	putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212
362242006620	Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977
362242006621	active site
362242006622	catalytic site [active]
362242006623	tetramer interface [polypeptide binding]; other site
362242006624	allantoicase; Provisional; Region: PRK13257
362242006625	Allantoicase repeat; Region: Allantoicase; pfam03561
362242006626	Allantoicase repeat; Region: Allantoicase; pfam03561
362242006627	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
362242006630	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
362242006631	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242006632	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242006633	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
362242006634	PPE family; Region: PPE; pfam00823
362242006635	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242006636	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242006637	Transposase; Region: HTH_Tnp_1; cl17663
362242006638	SIR2-like domain; Region: SIR2_2; pfam13289
362242006639	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
362242006640	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
362242006641	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
362242006642	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
362242006643	Active Sites [active]
362242006644	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
362242006645	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
362242006646	putative active site [active]
362242006647	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414
362242006648	putative active site [active]
362242006649	Transcriptional regulator [Transcription]; Region: LysR; COG0583
362242006650	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
362242006651	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
362242006652	dimerization interface [polypeptide binding]; other site
362242006653	ferredoxin-NADP+ reductase; Region: PLN02852
362242006654	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
362242006655	4Fe-4S binding domain; Region: Fer4; cl02805
362242006656	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
362242006657	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
362242006658	PE family; Region: PE; pfam00934
362242006659	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
362242006660	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
362242006661	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
362242006662	Tocopherol cyclase; Region: Tocopherol_cycl; cl14571
362242006663	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
362242006664	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
362242006665	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
362242006666	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
362242006667	active site
362242006668	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
362242006669	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
362242006670	Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394
362242006671	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242006672	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242006673	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242006674	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
362242006675	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
362242006676	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
362242006677	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
362242006678	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
362242006679	propionate catabolism operon regulatory protein PrpR; Provisional; Region: PRK15424
362242006680	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
362242006681	PPE family; Region: PPE; pfam00823
362242006682	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
362242006683	CDP-diacylglycerol pyrophosphatase; Provisional; Region: PRK05471
362242006684	Peptidase family M23; Region: Peptidase_M23; pfam01551
362242006685	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
362242006686	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
362242006687	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
362242006688	Protein of unknown function (DUF732); Region: DUF732; pfam05305
362242006689	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838
362242006690	active site
362242006691	metal binding site [ion binding]; metal-binding site
362242006692	Uncharacterized ACR, COG1993; Region: DUF190; cl00872
362242006693	Uncharacterized ACR, COG1993; Region: DUF190; cl00872
362242006694	Uncharacterized ACR, COG1993; Region: DUF190; cl00872
362242006695	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
362242006696	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
362242006697	pyridoxal 5'-phosphate binding site [chemical binding]; other site
362242006698	homodimer interface [polypeptide binding]; other site
362242006699	catalytic residue [active]
362242006700	Predicted transcriptional regulators [Transcription]; Region: COG1695
362242006701	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
362242006702	Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400
362242006703	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
362242006704	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
362242006705	active site
362242006706	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242006707	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242006708	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242006709	Transposase, Mutator family; Region: Transposase_mut; pfam00872
362242006710	MULE transposase domain; Region: MULE; pfam10551
362242006711	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242006712	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242006713	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242006714	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
362242006715	PPE family; Region: PPE; pfam00823
362242006716	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
362242006717	Amidohydrolase; Region: Amidohydro_2; pfam04909
362242006718	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
362242006719	S-adenosylmethionine binding site [chemical binding]; other site
362242006720	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
362242006721	cyclase homology domain; Region: CHD; cd07302
362242006722	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
362242006723	nucleotidyl binding site; other site
362242006724	metal binding site [ion binding]; metal-binding site
362242006725	dimer interface [polypeptide binding]; other site
362242006726	Predicted ATPase [General function prediction only]; Region: COG3903
362242006727	heat shock protein 90; Provisional; Region: PRK05218
362242006728	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
362242006729	ATP binding site [chemical binding]; other site
362242006730	Mg2+ binding site [ion binding]; other site
362242006731	G-X-G motif; other site
362242006732	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
362242006733	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
362242006734	active site
362242006735	catalytic tetrad [active]
362242006736	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
362242006737	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
362242006738	Rubredoxin [Energy production and conversion]; Region: COG1773
362242006739	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
362242006740	iron binding site [ion binding]; other site
362242006741	Rubredoxin [Energy production and conversion]; Region: COG1773
362242006742	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
362242006743	iron binding site [ion binding]; other site
362242006744	Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512
362242006745	Fatty acid desaturase; Region: FA_desaturase; pfam00487
362242006746	Di-iron ligands [ion binding]; other site
362242006747	Transposase, Mutator family; Region: Transposase_mut; pfam00872
362242006748	MULE transposase domain; Region: MULE; pfam10551
362242006749	short chain dehydrogenase; Provisional; Region: PRK06482
362242006750	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
362242006751	NAD(P) binding site [chemical binding]; other site
362242006752	active site
362242006753	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
362242006754	NAD(P) binding site [chemical binding]; other site
362242006755	active site
362242006756	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
362242006757	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
362242006758	active site
362242006759	enoyl-CoA hydratase; Provisional; Region: PRK09245
362242006760	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
362242006761	substrate binding site [chemical binding]; other site
362242006762	oxyanion hole (OAH) forming residues; other site
362242006763	trimer interface [polypeptide binding]; other site
362242006764	Transcriptional regulator [Transcription]; Region: IclR; COG1414
362242006765	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
362242006767	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
362242006768	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
362242006769	S-adenosylmethionine binding site [chemical binding]; other site
362242006770	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
362242006771	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
362242006772	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
362242006773	RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808
362242006774	active site
362242006775	NTP binding site [chemical binding]; other site
362242006776	nucleic acid binding site [nucleotide binding]; other site
362242006777	Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far.  This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases).  Plant T2 RNases are expressed during leaf...; Region: RNase_T2; cl00208
362242006778	CAS motifs; other site
362242006779	active site
362242006780	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
362242006781	Mechanosensitive ion channel; Region: MS_channel; pfam00924
362242006782	Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699
362242006783	marine proteobacterial sortase target protein; Region: marine_srt_targ; TIGR03788
362242006784	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
362242006785	metal ion-dependent adhesion site (MIDAS); other site
362242006786	Domain of unknown function (DUF4349); Region: DUF4349; pfam14257
362242006787	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242006788	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242006789	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242006790	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
362242006791	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
362242006792	Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968
362242006793	Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437
362242006794	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
362242006795	PE family; Region: PE; pfam00934
362242006796	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
362242006797	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
362242006798	Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435
362242006799	gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473
362242006800	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
362242006801	NAD(P) binding site [chemical binding]; other site
362242006802	catalytic residues [active]
362242006803	AsnC family; Region: AsnC_trans_reg; pfam01037
362242006804	hypothetical protein; Provisional; Region: PRK06541
362242006805	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
362242006806	inhibitor-cofactor binding pocket; inhibition site
362242006807	pyridoxal 5'-phosphate binding site [chemical binding]; other site
362242006808	catalytic residue [active]
362242006809	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
362242006810	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
362242006811	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
362242006812	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
362242006813	short chain dehydrogenase; Provisional; Region: PRK06179
362242006814	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
362242006815	NADP binding site [chemical binding]; other site
362242006816	active site
362242006817	steroid binding site; other site
362242006818	Domain of unknown function (DUF385); Region: DUF385; cl04387
362242006819	Rifampin ADP-ribosyl transferase; Region: Arr-ms; pfam12120
362242006820	2-enoyl thioester reductase (ETR) like proteins, child 1; Region: ETR_like_1; cd08291
362242006821	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
362242006822	NADP binding site [chemical binding]; other site
362242006823	dimer interface [polypeptide binding]; other site
362242006824	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
362242006825	Amidase; Region: Amidase; pfam01425
362242006826	Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511
362242006827	Phosphoesterase family; Region: Phosphoesterase; pfam04185
362242006828	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
362242006829	active site
362242006830	catalytic triad [active]
362242006831	oxyanion hole [active]
362242006832	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
362242006833	ThiS interaction site; other site
362242006834	putative active site [active]
362242006835	tetramer interface [polypeptide binding]; other site
362242006836	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
362242006837	thiS-thiF/thiG interaction site; other site
362242006838	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
362242006839	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
362242006840	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
362242006841	thiamine phosphate binding site [chemical binding]; other site
362242006842	active site
362242006843	pyrophosphate binding site [ion binding]; other site
362242006844	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
362242006845	nudix motif; other site
362242006846	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
362242006847	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
362242006848	substrate binding pocket [chemical binding]; other site
362242006849	membrane-bound complex binding site; other site
362242006850	hinge residues; other site
362242006851	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
362242006852	Catalytic domain of Protein Kinases; Region: PKc; cd00180
362242006853	active site
362242006854	ATP binding site [chemical binding]; other site
362242006855	substrate binding site [chemical binding]; other site
362242006856	activation loop (A-loop); other site
362242006857	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
362242006858	putative active site [active]
362242006859	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
362242006860	propionate/acetate kinase; Provisional; Region: PRK12379
362242006861	glucose-6-phosphate dehydrogenase (coenzyme-F420); Region: F420_G6P_DH; TIGR03554
362242006862	probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620
362242006863	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
362242006864	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
362242006865	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242006866	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242006867	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242006868	Protein of unknown function (DUF3054); Region: DUF3054; pfam11255
362242006869	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
362242006870	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
362242006871	active site
362242006872	Transposase, Mutator family; Region: Transposase_mut; pfam00872
362242006873	MULE transposase domain; Region: MULE; pfam10551
362242006874	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242006875	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242006876	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242006878	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
362242006879	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
362242006880	substrate binding pocket [chemical binding]; other site
362242006882	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
362242006883	CoenzymeA binding site [chemical binding]; other site
362242006884	subunit interaction site [polypeptide binding]; other site
362242006885	PHB binding site; other site
362242006886	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
362242006887	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
362242006888	GDP-binding site [chemical binding]; other site
362242006889	ACT binding site; other site
362242006890	IMP binding site; other site
362242006891	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
362242006892	Peptidase family M50; Region: Peptidase_M50; pfam02163
362242006893	active site
362242006894	putative substrate binding region [chemical binding]; other site
362242006895	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
362242006896	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
362242006897	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
362242006898	Protein of unknown function (DUF3151); Region: DUF3151; pfam11349
362242006899	7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156
362242006900	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
362242006901	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242006902	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242006903	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242006904	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
362242006905	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
362242006906	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
362242006907	Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029
362242006908	G1 box; other site
362242006909	GTP/Mg2+ binding site [chemical binding]; other site
362242006910	G2 box; other site
362242006911	Switch I region; other site
362242006912	G3 box; other site
362242006913	Switch II region; other site
362242006914	G4 box; other site
362242006915	G5 box; other site
362242006916	Protein of unknown function (DUF742); Region: DUF742; pfam05331
362242006917	Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018
362242006918	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
362242006919	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
362242006920	ATP binding site [chemical binding]; other site
362242006921	Mg2+ binding site [ion binding]; other site
362242006922	G-X-G motif; other site
362242006923	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
362242006924	S-adenosylmethionine binding site [chemical binding]; other site
362242006925	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
362242006926	PE family; Region: PE; pfam00934
362242006928	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062
362242006929	FMN binding site [chemical binding]; other site
362242006930	dimer interface [polypeptide binding]; other site
362242006931	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242006932	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242006933	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242006934	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
362242006935	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242006936	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242006937	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242006938	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
362242006939	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
362242006940	mce related protein; Region: MCE; pfam02470
362242006941	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
362242006942	mce related protein; Region: MCE; pfam02470
362242006943	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
362242006944	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
362242006945	mce related protein; Region: MCE; pfam02470
362242006946	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
362242006947	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
362242006948	mce related protein; Region: MCE; pfam02470
362242006949	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
362242006950	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
362242006951	Permease; Region: Permease; pfam02405
362242006952	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
362242006953	Permease; Region: Permease; pfam02405
362242006954	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
362242006955	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
362242006956	SnoaL-like domain; Region: SnoaL_2; pfam12680
362242006957	GAF domain; Region: GAF; cl17456
362242006958	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
362242006959	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
362242006960	DNA binding residues [nucleotide binding]
362242006961	dimerization interface [polypeptide binding]; other site
362242006962	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
362242006963	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
362242006964	NAD(P) binding site [chemical binding]; other site
362242006965	catalytic residues [active]
362242006966	SCP-2 sterol transfer family; Region: SCP2; cl01225
362242006967	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
362242006968	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
362242006969	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
362242006970	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
362242006971	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
362242006972	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
362242006973	putative Zn2+ binding site [ion binding]; other site
362242006974	putative DNA binding site [nucleotide binding]; other site
362242006975	dimerization interface [polypeptide binding]; other site
362242006976	classical (c) SDR, subgroup 12; Region: SDR_c12; cd08944
362242006977	putative NAD(P) binding site [chemical binding]; other site
362242006978	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06550
362242006979	active site
362242006980	homodimer interface [polypeptide binding]; other site
362242006981	3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108
362242006982	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
362242006983	GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925
362242006984	dimerization interface [polypeptide binding]; other site
362242006985	active site
362242006986	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
362242006987	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
362242006988	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
362242006989	anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872
362242006990	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
362242006991	catalytic loop [active]
362242006992	iron binding site [ion binding]; other site
362242006993	Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209
362242006994	FAD binding pocket [chemical binding]; other site
362242006995	FAD binding motif [chemical binding]; other site
362242006996	phosphate binding motif [ion binding]; other site
362242006997	beta-alpha-beta structure motif; other site
362242006998	NAD binding pocket [chemical binding]; other site
362242006999	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
362242007000	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
362242007001	Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152
362242007002	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
362242007003	FAD binding site [chemical binding]; other site
362242007004	substrate binding site [chemical binding]; other site
362242007005	catalytic base [active]
362242007006	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
362242007007	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
362242007008	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
362242007009	Acyl-CoA dehydrogenase, C-terminal domain; Region: Acyl-CoA_dh_1; pfam00441
362242007010	active site
362242007011	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
362242007012	dimer interface [polypeptide binding]; other site
362242007013	catalytic triad [active]
362242007014	peroxidatic and resolving cysteines [active]
362242007015	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
362242007016	Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641
362242007017	FeS/SAM binding site; other site
362242007018	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242007019	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242007020	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242007021	Transposase, Mutator family; Region: Transposase_mut; pfam00872
362242007022	MULE transposase domain; Region: MULE; pfam10551
362242007023	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242007024	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242007025	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242007026	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
362242007027	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
362242007028	conserved cys residue [active]
362242007029	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
362242007030	RibD C-terminal domain; Region: RibD_C; cl17279
362242007031	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
362242007032	SnoaL-like domain; Region: SnoaL_2; pfam12680
362242007033	Uncharacterized conserved protein (COG2071); Region: DUF2071; pfam09844
362242007034	Protein of unknown function (DUF3478); Region: DUF3478; pfam11964
362242007035	Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812
362242007036	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
362242007037	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
362242007038	Transposase, Mutator family; Region: Transposase_mut; pfam00872
362242007039	MULE transposase domain; Region: MULE; pfam10551
362242007040	hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203
362242007041	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
362242007042	active site
362242007043	putative substrate binding pocket [chemical binding]; other site
362242007044	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242007045	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242007046	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242007047	putative fatty-acid--CoA ligase; Provisional; Region: PRK12476
362242007048	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
362242007049	acyl-activating enzyme (AAE) consensus motif; other site
362242007050	active site
362242007051	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
362242007052	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
362242007053	Predicted membrane protein [Function unknown]; Region: COG1950
362242007054	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
362242007055	anti sigma factor interaction site; other site
362242007056	regulatory phosphorylation site [posttranslational modification]; other site
362242007057	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
362242007058	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
362242007059	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242007060	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242007061	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242007062	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
362242007063	PPE family; Region: PPE; pfam00823
362242007064	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
362242007065	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
362242007066	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
362242007067	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
362242007068	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
362242007069	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
362242007070	NAD(P) binding site [chemical binding]; other site
362242007071	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
362242007072	putative hydrophobic ligand binding site [chemical binding]; other site
362242007073	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
362242007074	dimerization interface [polypeptide binding]; other site
362242007075	putative DNA binding site [nucleotide binding]; other site
362242007076	putative Zn2+ binding site [ion binding]; other site
362242007077	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242007078	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242007079	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242007080	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
362242007081	tetramer interface [polypeptide binding]; other site
362242007082	active site
362242007083	Mg2+/Mn2+ binding site [ion binding]; other site
362242007084	Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435
362242007085	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
362242007086	putative hydrophobic ligand binding site [chemical binding]; other site
362242007087	protein interface [polypeptide binding]; other site
362242007088	gate; other site
362242007089	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
362242007090	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
362242007091	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
362242007092	Beta-lactamase; Region: Beta-lactamase; pfam00144
362242007093	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
362242007094	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
362242007095	Transposase, Mutator family; Region: Transposase_mut; pfam00872
362242007096	MULE transposase domain; Region: MULE; pfam10551
362242007097	putative sialic acid transporter; Region: 2A0112; TIGR00891
362242007098	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
362242007099	putative substrate translocation pore; other site
362242007100	competence damage-inducible protein A; Provisional; Region: PRK00549
362242007101	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
362242007102	putative MPT binding site; other site
362242007103	Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546
362242007104	Macro domain, Unknown family 2. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_2; cd03330
362242007105	putative ADP-ribose binding site [chemical binding]; other site
362242007106	Domain of unknown function DUF77; Region: DUF77; pfam01910
362242007107	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
362242007108	putative active site [active]
362242007109	dimerization interface [polypeptide binding]; other site
362242007110	putative tRNAtyr binding site [nucleotide binding]; other site
362242007111	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
362242007112	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
362242007113	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
362242007114	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
362242007115	NAD(P) binding site [chemical binding]; other site
362242007116	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
362242007117	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD_like; cd08296
362242007118	putative NAD(P) binding site [chemical binding]; other site
362242007119	putative substrate binding site [chemical binding]; other site
362242007120	catalytic Zn binding site [ion binding]; other site
362242007121	structural Zn binding site [ion binding]; other site
362242007122	YceI-like domain; Region: YceI; smart00867
362242007123	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242007124	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242007125	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242007126	Putative esterase; Region: Esterase; pfam00756
362242007127	probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621
362242007128	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
362242007129	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
362242007130	chorismate mutase; Provisional; Region: PRK09269
362242007131	chorismate mutase, putative; Region: CM_mono2; TIGR01806
362242007132	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
362242007133	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
362242007134	hydrophobic ligand binding site; other site
362242007135	short chain dehydrogenase; Provisional; Region: PRK08267
362242007136	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
362242007137	NAD(P) binding site [chemical binding]; other site
362242007138	active site
362242007139	Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481
362242007140	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
362242007141	Cytochrome P450; Region: p450; cl12078
362242007142	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
362242007143	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
362242007144	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242007145	Transposase, Mutator family; Region: Transposase_mut; pfam00872
362242007146	MULE transposase domain; Region: MULE; pfam10551
362242007147	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242007148	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242007149	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242007150	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
362242007151	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
362242007152	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
362242007153	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
362242007154	heme binding site [chemical binding]; other site
362242007155	ferroxidase pore; other site
362242007156	ferroxidase diiron center [ion binding]; other site
362242007157	Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906
362242007158	enoyl-CoA hydratase; Provisional; Region: PRK06688
362242007159	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
362242007160	substrate binding site [chemical binding]; other site
362242007161	oxyanion hole (OAH) forming residues; other site
362242007162	trimer interface [polypeptide binding]; other site
362242007163	PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618
362242007164	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
362242007165	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
362242007166	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
362242007167	dimerization interface [polypeptide binding]; other site
362242007168	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
362242007169	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
362242007170	dimer interface [polypeptide binding]; other site
362242007171	decamer (pentamer of dimers) interface [polypeptide binding]; other site
362242007172	catalytic triad [active]
362242007173	peroxidatic and resolving cysteines [active]
362242007174	alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777
362242007175	alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778
362242007176	Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like; cd11354
362242007177	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
362242007178	active site
362242007179	catalytic site [active]
362242007180	Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809
362242007181	FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070
362242007182	active site
362242007183	substrate binding site [chemical binding]; other site
362242007184	FMN binding site [chemical binding]; other site
362242007185	putative catalytic residues [active]
362242007186	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
362242007187	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
362242007188	Walker A motif; other site
362242007189	ATP binding site [chemical binding]; other site
362242007190	Walker B motif; other site
362242007191	arginine finger; other site
362242007192	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
362242007193	Domain of unknown function (DUF385); Region: DUF385; pfam04075
362242007194	Protein of unknown function, DUF606; Region: DUF606; pfam04657
362242007195	hypothetical protein; Provisional; Region: PRK12320
362242007196	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
362242007197	NAD(P) binding site [chemical binding]; other site
362242007198	active site
362242007199	acetyl-CoA acetyltransferase; Validated; Region: PRK08257
362242007200	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
362242007201	active site
362242007202	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
362242007203	Coenzyme A binding pocket [chemical binding]; other site
362242007204	short chain dehydrogenase; Provisional; Region: PRK07825
362242007205	classical (c) SDRs; Region: SDR_c; cd05233
362242007206	NAD(P) binding site [chemical binding]; other site
362242007207	active site
362242007208	putative phosphoketolase; Provisional; Region: PRK05261
362242007209	Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011
362242007210	TPP-binding site; other site
362242007211	XFP C-terminal domain; Region: XFP_C; pfam09363
362242007212	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
362242007213	MOSC domain; Region: MOSC; pfam03473
362242007214	3-alpha domain; Region: 3-alpha; pfam03475
362242007215	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
362242007216	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822
362242007217	NAD(P) binding site [chemical binding]; other site
362242007218	Fibronectin-attachment protein (FAP); Region: FAP; pfam07174
362242007219	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
362242007220	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
362242007221	Walker A/P-loop; other site
362242007222	ATP binding site [chemical binding]; other site
362242007223	Q-loop/lid; other site
362242007224	ABC transporter signature motif; other site
362242007225	Walker B; other site
362242007226	D-loop; other site
362242007227	H-loop/switch region; other site
362242007228	TOBE domain; Region: TOBE; pfam03459
362242007229	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
362242007230	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
362242007231	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
362242007232	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
362242007233	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
362242007234	dimer interface [polypeptide binding]; other site
362242007235	conserved gate region; other site
362242007236	putative PBP binding loops; other site
362242007237	ABC-ATPase subunit interface; other site
362242007238	ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725
362242007239	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
362242007240	classical (c) SDRs; Region: SDR_c; cd05233
362242007241	gluconate 5-dehydrogenase; Provisional; Region: PRK08213
362242007242	NAD(P) binding site [chemical binding]; other site
362242007243	active site
362242007244	probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560
362242007245	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
362242007246	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
362242007247	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
362242007248	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
362242007249	UreD urease accessory protein; Region: UreD; cl00530
362242007250	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
362242007251	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
362242007252	UreF; Region: UreF; pfam01730
362242007253	urease subunit alpha; Reviewed; Region: ureC; PRK13206
362242007254	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
362242007255	subunit interactions [polypeptide binding]; other site
362242007256	active site
362242007257	flap region; other site
362242007258	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
362242007259	gamma-beta subunit interface [polypeptide binding]; other site
362242007260	alpha-beta subunit interface [polypeptide binding]; other site
362242007261	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
362242007262	alpha-gamma subunit interface [polypeptide binding]; other site
362242007263	beta-gamma subunit interface [polypeptide binding]; other site
362242007264	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
362242007265	CoenzymeA binding site [chemical binding]; other site
362242007266	subunit interaction site [polypeptide binding]; other site
362242007267	PHB binding site; other site
362242007268	Predicted transcriptional regulator [Transcription]; Region: COG3682
362242007269	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
362242007270	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
362242007271	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
362242007272	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
362242007273	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807
362242007274	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
362242007275	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
362242007276	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
362242007277	active site
362242007278	hypothetical protein; Provisional; Region: PRK05858
362242007279	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
362242007280	PYR/PP interface [polypeptide binding]; other site
362242007281	dimer interface [polypeptide binding]; other site
362242007282	TPP binding site [chemical binding]; other site
362242007283	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
362242007284	Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004
362242007285	TPP-binding site; other site
362242007286	dimer interface [polypeptide binding]; other site
362242007287	preprotein translocase subunit SecA; Reviewed; Region: PRK12326
362242007288	SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043
362242007289	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
362242007290	nucleotide binding region [chemical binding]; other site
362242007291	ATP-binding site [chemical binding]; other site
362242007292	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
362242007293	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879
362242007294	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
362242007295	Protein of unknown function (DUF1290); Region: DUF1290; cl01587
362242007296	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879
362242007297	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
362242007298	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
362242007299	lipoyl attachment site [posttranslational modification]; other site
362242007300	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
362242007301	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
362242007302	phosphopeptide binding site; other site
362242007303	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
362242007304	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
362242007305	DNA binding residues [nucleotide binding]
362242007306	Bifunctional nuclease; Region: DNase-RNase; pfam02577
362242007307	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
362242007308	DNA binding residues [nucleotide binding]
362242007309	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
362242007310	putative dimer interface [polypeptide binding]; other site
362242007311	glycine dehydrogenase; Provisional; Region: PRK05367
362242007312	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
362242007313	pyridoxal 5'-phosphate binding site [chemical binding]; other site
362242007314	tetramer interface [polypeptide binding]; other site
362242007315	catalytic residue [active]
362242007316	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
362242007317	tetramer interface [polypeptide binding]; other site
362242007318	pyridoxal 5'-phosphate binding site [chemical binding]; other site
362242007319	catalytic residue [active]
362242007320	haloalkane dehalogenase; Provisional; Region: PRK03204
362242007321	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
362242007322	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
362242007323	metal ion-dependent adhesion site (MIDAS); other site
362242007324	Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728
362242007325	active site
362242007326	PE family; Region: PE; pfam00934
362242007327	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
362242007328	ABC transporter transmembrane region 2; Region: ABC_membrane_2; pfam06472
362242007329	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
362242007330	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242007331	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242007332	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242007333	Transposase, Mutator family; Region: Transposase_mut; pfam00872
362242007334	MULE transposase domain; Region: MULE; pfam10551
362242007335	PE family; Region: PE; pfam00934
362242007336	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
362242007337	metal binding site [ion binding]; metal-binding site
362242007338	substrate binding site [chemical binding]; other site
362242007339	dimer interface [polypeptide binding]; other site
362242007340	hypothetical protein; Validated; Region: PRK07121
362242007341	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
362242007342	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242007343	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242007344	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242007345	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
362242007346	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
362242007347	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
362242007348	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
362242007349	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
362242007350	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
362242007351	MgtC family; Region: MgtC; pfam02308
362242007352	Protein of unknown function (DUF732); Region: DUF732; pfam05305
362242007353	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
362242007354	PPE family; Region: PPE; pfam00823
362242007355	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
362242007356	PPE family; Region: PPE; pfam00823
362242007357	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
362242007358	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
362242007359	PPE family; Region: PPE; pfam00823
362242007360	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
362242007361	PPE family; Region: PPE; pfam00823
362242007362	type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922
362242007363	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
362242007364	Walker A motif; other site
362242007365	ATP binding site [chemical binding]; other site
362242007366	Walker B motif; other site
362242007367	arginine finger; other site
362242007368	type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923
362242007369	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
362242007370	catalytic residues [active]
362242007371	type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921
362242007372	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306
362242007373	active site
362242007374	catalytic residues [active]
362242007375	type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920
362242007376	EspG family; Region: ESX-1_EspG; pfam14011
362242007377	Proteins of 100 residues with WXG; Region: WXG100; pfam06013
362242007378	WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930
362242007379	PE family; Region: PE; pfam00934
362242007380	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
362242007381	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242007382	Protein of unknown function (DUF732); Region: DUF732; pfam05305
362242007383	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
362242007384	PPE family; Region: PPE; pfam00823
362242007385	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
362242007386	PE family; Region: PE; pfam00934
362242007387	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
362242007388	PPE family; Region: PPE; pfam00823
362242007389	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
362242007390	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
362242007391	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
362242007392	Cytochrome P450; Region: p450; cl12078
362242007393	type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924
362242007394	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
362242007395	type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925
362242007396	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
362242007397	Protein of unknown function (DUF690); Region: DUF690; pfam05108
362242007398	4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052
362242007399	4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640
362242007401	TAP-like protein; Region: Abhydrolase_4; pfam08386
362242007402	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
362242007403	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
362242007404	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
362242007405	Domain of unknown function (DUF4344); Region: DUF4344; pfam14247
362242007406	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
362242007407	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
362242007408	classical (c) SDRs; Region: SDR_c; cd05233
362242007409	NAD(P) binding site [chemical binding]; other site
362242007410	active site
362242007411	Uncharacterized conserved protein [Function unknown]; Region: COG0393
362242007412	Putative heavy-metal-binding; Region: YbjQ_1; cl00426
362242007413	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
362242007414	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
362242007415	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
362242007416	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
362242007417	S-adenosylmethionine binding site [chemical binding]; other site
362242007418	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
362242007419	catalytic residues [active]
362242007420	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
362242007421	putative homotetramer interface [polypeptide binding]; other site
362242007422	putative homodimer interface [polypeptide binding]; other site
362242007423	putative allosteric switch controlling residues; other site
362242007424	putative metal binding site [ion binding]; other site
362242007425	putative homodimer-homodimer interface [polypeptide binding]; other site
362242007426	Domain of unknown function DUF302; Region: DUF302; pfam03625
362242007427	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
362242007428	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
362242007429	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813
362242007430	dimer interface [polypeptide binding]; other site
362242007431	active site
362242007432	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
362242007433	substrate binding site [chemical binding]; other site
362242007434	catalytic residue [active]
362242007435	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
362242007436	Peptidase family M28; Region: Peptidase_M28; pfam04389
362242007437	metal binding site [ion binding]; metal-binding site
362242007438	FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679
362242007439	FAD binding domain; Region: FAD_binding_4; pfam01565
362242007440	D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030
362242007441	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
362242007442	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
362242007443	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
362242007444	PPE family; Region: PPE; pfam00823
362242007445	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
362242007448	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
362242007449	Cytochrome P450; Region: p450; cl12078
362242007450	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242007451	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242007452	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242007453	short chain dehydrogenase; Provisional; Region: PRK08267
362242007454	classical (c) SDRs; Region: SDR_c; cd05233
362242007455	NAD(P) binding site [chemical binding]; other site
362242007456	active site
362242007457	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
362242007458	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
362242007459	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
362242007460	Amidohydrolase; Region: Amidohydro_2; pfam04909
362242007461	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007
362242007462	intersubunit interface [polypeptide binding]; other site
362242007463	active site
362242007464	Zn2+ binding site [ion binding]; other site
362242007465	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
362242007466	AMP-binding enzyme; Region: AMP-binding; pfam00501
362242007467	acyl-activating enzyme (AAE) consensus motif; other site
362242007468	AMP binding site [chemical binding]; other site
362242007469	active site
362242007470	CoA binding site [chemical binding]; other site
362242007471	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
362242007472	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
362242007473	Coenzyme A binding pocket [chemical binding]; other site
362242007474	Peptidase family M48; Region: Peptidase_M48; pfam01435
362242007475	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
362242007476	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
362242007477	phosphopeptide binding site; other site
362242007478	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
362242007479	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
362242007480	phosphopeptide binding site; other site
362242007481	Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213
362242007482	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
362242007483	Walker A/P-loop; other site
362242007484	ATP binding site [chemical binding]; other site
362242007485	Q-loop/lid; other site
362242007486	ABC transporter signature motif; other site
362242007487	Walker B; other site
362242007488	D-loop; other site
362242007489	H-loop/switch region; other site
362242007490	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
362242007491	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
362242007492	Uncharacterized conserved protein [Function unknown]; Region: COG5361
362242007493	Protein of unknown function (DUF1254); Region: DUF1254; pfam06863
362242007494	Protein of unknown function (DUF1214); Region: DUF1214; pfam06742
362242007495	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242007496	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242007497	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242007498	Transposase, Mutator family; Region: Transposase_mut; pfam00872
362242007499	MULE transposase domain; Region: MULE; pfam10551
362242007500	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
362242007501	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
362242007502	molybdopterin cofactor binding site; other site
362242007503	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
362242007504	Major Facilitator Superfamily; Region: MFS_1; pfam07690
362242007505	putative substrate translocation pore; other site
362242007506	Protein of unknown function (DUF1330); Region: DUF1330; cl02288
362242007507	Cupin domain; Region: Cupin_2; cl17218
362242007508	classical (c) SDRs; Region: SDR_c; cd05233
362242007509	short chain dehydrogenase; Provisional; Region: PRK07832
362242007510	NAD(P) binding site [chemical binding]; other site
362242007511	active site
362242007512	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
362242007513	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
362242007514	Protein of unknown function (DUF1298); Region: DUF1298; pfam06974
362242007515	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
362242007516	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
362242007517	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
362242007518	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
362242007519	classical (c) SDRs; Region: SDR_c; cd05233
362242007520	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
362242007521	NAD(P) binding site [chemical binding]; other site
362242007522	active site
362242007523	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
362242007524	PPE family; Region: PPE; pfam00823
362242007525	NYN domain; Region: NYN; pfam01936
362242007526	putative metal binding site [ion binding]; other site
362242007527	C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146
362242007528	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
362242007529	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
362242007530	catalytic residue [active]
362242007531	putative FPP diphosphate  binding site; other site
362242007532	putative FPP binding hydrophobic cleft; other site
362242007533	dimer interface [polypeptide binding]; other site
362242007534	putative IPP diphosphate binding site; other site
362242007535	Protein of unknown function (DUF1295); Region: DUF1295; cl17837
362242007536	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
362242007537	Domain of unknown function (DUF4185); Region: DUF4185; pfam13810
362242007538	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
362242007539	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
362242007540	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
362242007541	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
362242007542	RNA binding site [nucleotide binding]; other site
362242007543	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
362242007544	TrkA-N domain; Region: TrkA_N; pfam02254
362242007545	TrkA-C domain; Region: TrkA_C; pfam02080
362242007546	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
362242007547	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
362242007548	TrkA-C domain; Region: TrkA_C; pfam02080
362242007549	Acyltransferase family; Region: Acyl_transf_3; pfam01757
362242007550	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242007551	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242007552	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242007553	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
362242007554	Catalytic domain of Protein Kinases; Region: PKc; cd00180
362242007555	active site
362242007556	ATP binding site [chemical binding]; other site
362242007557	substrate binding site [chemical binding]; other site
362242007558	activation loop (A-loop); other site
362242007559	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
362242007560	amino acid transporter; Region: 2A0306; TIGR00909
362242007561	Protein of unknown function (DUF3478); Region: DUF3478; pfam11964
362242007562	PE family; Region: PE; pfam00934
362242007563	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
362242007564	putative substrate translocation pore; other site
362242007565	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
362242007566	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
362242007567	tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800
362242007568	succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407
362242007569	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101
362242007570	NAD(P) binding site [chemical binding]; other site
362242007571	catalytic residues [active]
362242007572	Choloylglycine hydrolase (CGH) is a bile salt-modifying enzyme that hydrolyzes non-peptide carbon-nitrogen bonds in choloylglycine and choloyltaurine, both of which are present in bile.  CGH is present in a number of probiotic microbial organisms that...; Region: Ntn_CGH; cd01902
362242007573	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
362242007574	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
362242007575	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
362242007576	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
362242007577	substrate binding pocket [chemical binding]; other site
362242007578	substrate-Mg2+ binding site; other site
362242007579	aspartate-rich region 1; other site
362242007580	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
362242007581	homotrimer interaction site [polypeptide binding]; other site
362242007582	putative active site [active]
362242007583	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224
362242007584	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224
362242007585	Uncharacterized conserved protein [Function unknown]; Region: COG1359
362242007586	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
362242007587	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
362242007588	DNA-binding site [nucleotide binding]; DNA binding site
362242007589	UTRA domain; Region: UTRA; pfam07702
362242007590	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
362242007591	probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560
362242007592	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
362242007593	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
362242007594	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
362242007595	active site
362242007596	catalytic residues [active]
362242007597	3-oxo-5-alpha-steroid 4-dehydrogenase; Region: Steroid_dh; cl17474
362242007602	Helix-turn-helix domain; Region: HTH_38; pfam13936
362242007603	Transposase, Mutator family; Region: Transposase_mut; pfam00872
362242007604	MULE transposase domain; Region: MULE; pfam10551
362242007606	TatD related DNase; Region: TatD_DNase; pfam01026
362242007607	active site
362242007608	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
362242007609	KAP family P-loop domain; Region: KAP_NTPase; pfam07693
362242007610	Predicted P-loop ATPase [General function prediction only]; Region: COG4928
362242007611	Protein of unknown function DUF45; Region: DUF45; pfam01863
362242007612	Transposase, Mutator family; Region: Transposase_mut; pfam00872
362242007613	MULE transposase domain; Region: MULE; pfam10551
362242007615	Transposase, Mutator family; Region: Transposase_mut; pfam00872
362242007616	MULE transposase domain; Region: MULE; pfam10551
362242007618	Transposase, Mutator family; Region: Transposase_mut; pfam00872
362242007619	MULE transposase domain; Region: MULE; pfam10551
362242007621	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242007622	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242007623	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242007625	Transposase, Mutator family; Region: Transposase_mut; pfam00872
362242007626	MULE transposase domain; Region: MULE; pfam10551
362242007628	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
362242007629	catalytic residues [active]
362242007630	Recombinase; Region: Recombinase; pfam07508
362242007631	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
362242007632	GTP-binding protein Der; Reviewed; Region: PRK03003
362242007633	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
362242007634	G1 box; other site
362242007635	GTP/Mg2+ binding site [chemical binding]; other site
362242007636	Switch I region; other site
362242007637	G2 box; other site
362242007638	Switch II region; other site
362242007639	G3 box; other site
362242007640	G4 box; other site
362242007641	G5 box; other site
362242007642	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
362242007643	G1 box; other site
362242007644	GTP/Mg2+ binding site [chemical binding]; other site
362242007645	Switch I region; other site
362242007646	G2 box; other site
362242007647	G3 box; other site
362242007648	Switch II region; other site
362242007649	G4 box; other site
362242007650	G5 box; other site
362242007651	cytidylate kinase; Provisional; Region: cmk; PRK00023
362242007652	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
362242007653	CMP-binding site; other site
362242007654	The sites determining sugar specificity; other site
362242007655	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
362242007656	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
362242007657	RNA binding surface [nucleotide binding]; other site
362242007658	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
362242007659	active site
362242007660	Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386
362242007661	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
362242007662	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
362242007663	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
362242007664	P loop; other site
362242007665	Nucleotide binding site [chemical binding]; other site
362242007666	DTAP/Switch II; other site
362242007667	Switch I; other site
362242007668	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
362242007669	Magnesium ion binding site [ion binding]; other site
362242007670	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242007671	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242007672	Transposase, Mutator family; Region: Transposase_mut; pfam00872
362242007673	MULE transposase domain; Region: MULE; pfam10551
362242007675	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
362242007676	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
362242007677	hypothetical protein; Validated; Region: PRK00110
362242007678	PE family; Region: PE; pfam00934
362242007681	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
362242007682	predicted active site [active]
362242007683	catalytic triad [active]
362242007684	acyl-CoA thioesterase II; Region: tesB; TIGR00189
362242007685	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
362242007686	active site
362242007687	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
362242007688	catalytic triad [active]
362242007689	dimer interface [polypeptide binding]; other site
362242007690	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
362242007691	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
362242007692	active site
362242007693	multimer interface [polypeptide binding]; other site
362242007694	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_26; cd04685
362242007695	nudix motif; other site
362242007696	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
362242007697	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
362242007698	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
362242007699	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
362242007700	putative acyl-acceptor binding pocket; other site
362242007701	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
362242007702	FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275
362242007703	nucleotide binding site/active site [active]
362242007704	HIT family signature motif; other site
362242007705	catalytic residue [active]
362242007706	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305
362242007707	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
362242007708	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
362242007709	active site
362242007710	dimer interface [polypeptide binding]; other site
362242007711	motif 1; other site
362242007712	motif 2; other site
362242007713	motif 3; other site
362242007714	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
362242007715	anticodon binding site; other site
362242007716	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
362242007717	CoenzymeA binding site [chemical binding]; other site
362242007718	subunit interaction site [polypeptide binding]; other site
362242007719	PHB binding site; other site
362242007720	Domain of unknown function (DUF1990); Region: DUF1990; pfam09348
362242007721	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
362242007722	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
362242007723	Predicted transcriptional regulator [Transcription]; Region: COG2345
362242007724	putative DNA binding site [nucleotide binding]; other site
362242007725	putative Zn2+ binding site [ion binding]; other site
362242007726	Ferredoxin [Energy production and conversion]; Region: COG1146
362242007727	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
362242007728	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
362242007729	S-adenosylmethionine binding site [chemical binding]; other site
362242007730	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
362242007731	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
362242007732	Ligand Binding Site [chemical binding]; other site
362242007733	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
362242007734	Ligand Binding Site [chemical binding]; other site
362242007735	SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164
362242007736	active site
362242007737	Peptidase family M50; Region: Peptidase_M50; pfam02163
362242007738	putative substrate binding region [chemical binding]; other site
362242007739	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612
362242007740	FOG: CBS domain [General function prediction only]; Region: COG0517
362242007741	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
362242007742	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
362242007743	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
362242007744	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
362242007745	acyl-activating enzyme (AAE) consensus motif; other site
362242007746	putative AMP binding site [chemical binding]; other site
362242007747	putative active site [active]
362242007748	putative CoA binding site [chemical binding]; other site
362242007749	Peptide chain release factor 1 (eRF1) [Translation, ribosomal structure and biogenesis]; Region: eRF1; COG1503
362242007750	peptide chain release factor 1; Provisional; Region: PRK04011
362242007751	Predicted phosphoribosyltransferases [General function prediction only]; Region: COG1926
362242007752	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
362242007753	Domain of unknown function (DUF1876); Region: DUF1876; pfam08962
362242007754	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
362242007755	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
362242007756	acyl-activating enzyme (AAE) consensus motif; other site
362242007757	acyl-activating enzyme (AAE) consensus motif; other site
362242007758	active site
362242007759	AMP binding site [chemical binding]; other site
362242007760	CoA binding site [chemical binding]; other site
362242007761	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
362242007762	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
362242007763	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
362242007764	anti sigma factor interaction site; other site
362242007765	regulatory phosphorylation site [posttranslational modification]; other site
362242007766	Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153
362242007767	putative heme binding pocket [chemical binding]; other site
362242007768	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
362242007769	putative DNA binding site [nucleotide binding]; other site
362242007770	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254
362242007771	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
362242007772	putative metal binding site [ion binding]; other site
362242007773	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
362242007774	dimerization interface [polypeptide binding]; other site
362242007775	putative DNA binding site [nucleotide binding]; other site
362242007776	putative Zn2+ binding site [ion binding]; other site
362242007777	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242007778	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242007779	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242007780	PE family; Region: PE; pfam00934
362242007785	TPR repeat; Region: TPR_11; pfam13414
362242007786	Tetratricopeptide repeat; Region: TPR_2; pfam07719
362242007787	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
362242007788	binding surface
362242007789	TPR motif; other site
362242007790	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
362242007791	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
362242007792	Protein of unknown function (DUF732); Region: DUF732; pfam05305
362242007793	Clp protease ATP binding subunit; Region: clpC; CHL00095
362242007794	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
362242007795	Coenzyme A binding pocket [chemical binding]; other site
362242007796	AFG1-like ATPase; Region: AFG1_ATPase; pfam03969
362242007797	hypothetical protein; Provisional; Region: PRK14059
362242007798	Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985
362242007799	Protein of unknown function (DUF2029); Region: DUF2029; pfam09594
362242007800	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229
362242007801	SelR domain; Region: SelR; pfam01641
362242007802	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
362242007803	Methyltransferase domain; Region: Methyltransf_31; pfam13847
362242007804	S-adenosylmethionine binding site [chemical binding]; other site
362242007805	Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253
362242007806	protoporphyrinogen oxidase; Reviewed; Region: PRK11883
362242007807	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
362242007808	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
362242007809	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
362242007810	substrate binding site [chemical binding]; other site
362242007811	active site
362242007812	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
362242007813	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
362242007814	substrate binding site [chemical binding]; other site
362242007815	oxyanion hole (OAH) forming residues; other site
362242007816	trimer interface [polypeptide binding]; other site
362242007817	Protein of unknown function (DUF3000); Region: DUF3000; pfam11452
362242007818	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
362242007819	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
362242007820	catalytic site [active]
362242007821	putative active site [active]
362242007822	putative substrate binding site [chemical binding]; other site
362242007823	Helicase and RNase D C-terminal; Region: HRDC; smart00341
362242007824	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242007825	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242007826	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242007827	PE family; Region: PE; pfam00934
362242007832	Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154
362242007833	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
362242007834	TPP-binding site; other site
362242007835	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
362242007836	PYR/PP interface [polypeptide binding]; other site
362242007837	dimer interface [polypeptide binding]; other site
362242007838	TPP binding site [chemical binding]; other site
362242007839	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
362242007840	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
362242007841	FOG: CBS domain [General function prediction only]; Region: COG0517
362242007842	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
362242007843	Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116
362242007844	transmembrane helices; other site
362242007845	TRAM domain; Region: TRAM; cl01282
362242007846	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
362242007847	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
362242007848	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
362242007849	TrkA-N domain; Region: TrkA_N; pfam02254
362242007850	TrkA-C domain; Region: TrkA_C; pfam02080
362242007851	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
362242007852	TrkA-N domain; Region: TrkA_N; pfam02254
362242007853	TrkA-C domain; Region: TrkA_C; pfam02080
362242007854	Protein of unknown function (DUF3159); Region: DUF3159; pfam11361
362242007855	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
362242007856	generic binding surface II; other site
362242007857	ssDNA binding site; other site
362242007858	Protein of unknown function (DUF3710); Region: DUF3710; pfam12502
362242007859	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
362242007860	trimer interface [polypeptide binding]; other site
362242007861	active site
362242007862	Protein of unknown function (DUF3093); Region: DUF3093; pfam11292
362242007863	Domain of unknown function (DUF4193); Region: DUF4193; pfam13834
362242007864	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
362242007865	FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289
362242007866	active site
362242007867	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
362242007868	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
362242007869	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
362242007870	nucleotide binding site [chemical binding]; other site
362242007871	RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921
362242007872	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
362242007873	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
362242007874	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
362242007875	DNA binding residues [nucleotide binding]
362242007876	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154
362242007877	homotrimer interaction site [polypeptide binding]; other site
362242007878	putative active site [active]
362242007879	Protein of unknown function (DUF952); Region: DUF952; cl01393
362242007880	Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295
362242007881	Protein of unknown function (DUF3039); Region: DUF3039; pfam11238
362242007882	Protein of unknown function (DUF3099); Region: DUF3099; pfam11298
362242007883	RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921
362242007884	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
362242007885	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
362242007886	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
362242007887	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
362242007888	DNA binding residues [nucleotide binding]
362242007889	Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
362242007890	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
362242007891	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
362242007892	This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899
362242007893	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242007894	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242007895	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242007896	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
362242007897	PAC2 family; Region: PAC2; pfam09754
362242007898	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
362242007899	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
362242007900	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
362242007901	nitrobindin heme-binding domain; Region: nitrobindin; cd07828
362242007902	heme-binding site [chemical binding]; other site
362242007903	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
362242007904	ATP cone domain; Region: ATP-cone; pfam03477
362242007905	LexA repressor; Validated; Region: PRK00215
362242007906	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
362242007907	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
362242007908	Catalytic site [active]
362242007909	Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479
362242007910	LGFP repeat; Region: LGFP; pfam08310
362242007911	LGFP repeat; Region: LGFP; pfam08310
362242007912	LGFP repeat; Region: LGFP; pfam08310
362242007913	LGFP repeat; Region: LGFP; pfam08310
362242007914	LGFP repeat; Region: LGFP; pfam08310
362242007915	Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325
362242007916	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
362242007917	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
362242007918	active site
362242007919	GTPases [General function prediction only]; Region: HflX; COG2262
362242007920	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
362242007921	HflX GTPase family; Region: HflX; cd01878
362242007922	G1 box; other site
362242007923	GTP/Mg2+ binding site [chemical binding]; other site
362242007924	Switch I region; other site
362242007925	G2 box; other site
362242007926	G3 box; other site
362242007927	Switch II region; other site
362242007928	G4 box; other site
362242007929	G5 box; other site
362242007930	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
362242007931	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
362242007932	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
362242007933	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
362242007934	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
362242007935	The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951
362242007936	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
362242007937	Catalytic domain of Protein Kinases; Region: PKc; cd00180
362242007938	active site
362242007939	ATP binding site [chemical binding]; other site
362242007940	substrate binding site [chemical binding]; other site
362242007941	activation loop (A-loop); other site
362242007942	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
362242007943	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
362242007944	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
362242007945	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326
362242007946	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
362242007947	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
362242007948	FeS/SAM binding site; other site
362242007949	TRAM domain; Region: TRAM; cl01282
362242007950	recombination regulator RecX; Reviewed; Region: recX; PRK00117
362242007951	recombinase A; Provisional; Region: recA; PRK09354
362242007952	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
362242007953	hexamer interface [polypeptide binding]; other site
362242007954	Walker A motif; other site
362242007955	ATP binding site [chemical binding]; other site
362242007956	Walker B motif; other site
362242007957	siderophore-iron reductase FhuF; Region: Fe_III_red_FhuF; TIGR03951
362242007958	FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575
362242007959	Protein of unknown function (DUF3046); Region: DUF3046; pfam11248
362242007960	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
362242007961	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
362242007962	Limonene-1,2-epoxide hydrolase catalytic domain; Region: LEH; pfam07858
362242007963	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
362242007964	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
362242007965	non-specific DNA binding site [nucleotide binding]; other site
362242007966	salt bridge; other site
362242007967	sequence-specific DNA binding site [nucleotide binding]; other site
362242007968	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
362242007969	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
362242007970	Coenzyme A binding pocket [chemical binding]; other site
362242007971	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
362242007972	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
362242007973	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
362242007974	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
362242007975	Uncharacterized conserved protein [Function unknown]; Region: COG1359
362242007976	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
362242007977	classical (c) SDRs; Region: SDR_c; cd05233
362242007978	NAD(P) binding site [chemical binding]; other site
362242007979	active site
362242007980	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
362242007981	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
362242007982	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242007983	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242007984	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
362242007985	Predicted flavoprotein [General function prediction only]; Region: COG0431
362242007986	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
362242007987	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
362242007988	short chain dehydrogenase; Provisional; Region: PRK07832
362242007989	classical (c) SDRs; Region: SDR_c; cd05233
362242007990	NAD(P) binding site [chemical binding]; other site
362242007991	active site
362242007992	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
362242007993	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
362242007994	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
362242007995	Cytochrome P450; Region: p450; cl12078
362242007996	MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417
362242007997	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
362242007998	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
362242007999	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
362242008000	active site
362242008001	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242008002	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242008003	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242008004	DUF35 OB-fold domain; Region: DUF35; pfam01796
362242008005	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
362242008006	S-adenosylmethionine binding site [chemical binding]; other site
362242008007	Predicted transcriptional regulators [Transcription]; Region: COG1733
362242008008	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
362242008009	dimerization interface [polypeptide binding]; other site
362242008010	putative DNA binding site [nucleotide binding]; other site
362242008011	putative Zn2+ binding site [ion binding]; other site
362242008012	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
362242008013	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
362242008014	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
362242008015	Acyl-CoA dehydrogenase, C-terminal domain; Region: Acyl-CoA_dh_1; pfam00441
362242008016	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
362242008017	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
362242008018	active site
362242008019	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
362242008020	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
362242008021	NAD(P) binding site [chemical binding]; other site
362242008022	active site
362242008023	ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180
362242008024	Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901
362242008025	active site
362242008026	DNA binding site [nucleotide binding]
362242008027	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972
362242008028	DNA binding site [nucleotide binding]
362242008029	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
362242008030	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
362242008031	ligand binding site [chemical binding]; other site
362242008032	flexible hinge region; other site
362242008033	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
362242008034	Transposase, Mutator family; Region: Transposase_mut; pfam00872
362242008035	MULE transposase domain; Region: MULE; pfam10551
362242008036	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242008037	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242008038	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242008039	Actin-like ATPase involved in cell morphogenesis [Cell division and chromosome partitioning]; Region: MreB; COG1077
362242008040	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
362242008041	nucleotide binding site [chemical binding]; other site
362242008042	putative NEF/HSP70 interaction site [polypeptide binding]; other site
362242008043	SBD interface [polypeptide binding]; other site
362242008044	short chain dehydrogenase; Provisional; Region: PRK06180
362242008045	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
362242008046	NADP binding site [chemical binding]; other site
362242008047	active site
362242008048	steroid binding site; other site
362242008049	HD domain protein, cyanamide hydratase family; Region: cyanamide_fam; TIGR03401
362242008050	Small Multidrug Resistance protein; Region: Multi_Drug_Res; pfam00893
362242008051	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226
362242008052	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
362242008053	Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015
362242008054	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
362242008055	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
362242008056	Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099
362242008057	NAD(P) binding site [chemical binding]; other site
362242008058	catalytic residues [active]
362242008059	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656
362242008060	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
362242008061	acyl-activating enzyme (AAE) consensus motif; other site
362242008062	putative AMP binding site [chemical binding]; other site
362242008063	putative active site [active]
362242008064	putative CoA binding site [chemical binding]; other site
362242008065	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
362242008066	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
362242008067	putative acyl-acceptor binding pocket; other site
362242008068	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
362242008069	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
362242008070	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
362242008071	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
362242008072	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242008073	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242008074	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242008075	Transposase, Mutator family; Region: Transposase_mut; pfam00872
362242008076	MULE transposase domain; Region: MULE; pfam10551
362242008081	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
362242008082	phosphoglucomutase; Validated; Region: PRK07564
362242008083	This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801
362242008084	active site
362242008085	substrate binding site [chemical binding]; other site
362242008086	metal binding site [ion binding]; metal-binding site
362242008087	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242008088	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242008089	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242008090	Uncharacterized ACR, COG1993; Region: DUF190; cl00872
362242008091	Uncharacterized ACR, COG1993; Region: DUF190; cl00872
362242008092	Uncharacterized ACR, COG1993; Region: DUF190; pfam02641
362242008093	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
362242008094	Siderophore biosynthesis protein domain; Region: AlcB; smart01006
362242008095	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
362242008096	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
362242008097	Protein of unknown function, DUF488; Region: DUF488; cl01246
362242008098	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
362242008099	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
362242008100	Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077
362242008101	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
362242008102	putative hydrophobic ligand binding site [chemical binding]; other site
362242008103	protein interface [polypeptide binding]; other site
362242008104	gate; other site
362242008105	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
362242008106	Sulfatase; Region: Sulfatase; pfam00884
362242008107	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
362242008108	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
362242008109	Domain of unknown function (DUF4267); Region: DUF4267; pfam14087
362242008110	hypothetical protein; Validated; Region: PRK00029
362242008111	Uncharacterized conserved protein [Function unknown]; Region: COG0397
362242008112	SPFH domain / Band 7 family; Region: Band_7; pfam01145
362242008113	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
362242008114	Protein of unknown function (DUF732); Region: DUF732; pfam05305
362242008115	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
362242008116	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
362242008117	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354
362242008118	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242008119	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242008120	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242008121	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
362242008122	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
362242008123	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334
362242008124	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
362242008125	homodimer interface [polypeptide binding]; other site
362242008126	metal binding site [ion binding]; metal-binding site
362242008127	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
362242008128	Prostaglandin dehydrogenases; Region: PGDH; cd05288
362242008129	NAD(P) binding site [chemical binding]; other site
362242008130	substrate binding site [chemical binding]; other site
362242008131	dimer interface [polypeptide binding]; other site
362242008132	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
362242008133	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
362242008134	active site
362242008135	Predicted transcriptional regulators [Transcription]; Region: COG1733
362242008136	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
362242008137	dimerization interface [polypeptide binding]; other site
362242008138	putative DNA binding site [nucleotide binding]; other site
362242008139	putative Zn2+ binding site [ion binding]; other site
362242008140	Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876
362242008141	LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041
362242008142	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721
362242008143	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242008144	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242008145	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900
362242008146	glutaminase; Reviewed; Region: PRK12356
362242008147	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
362242008148	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242008149	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242008150	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242008151	Transposase, Mutator family; Region: Transposase_mut; pfam00872
362242008152	MULE transposase domain; Region: MULE; pfam10551
362242008153	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
362242008154	TAP-like protein; Region: Abhydrolase_4; pfam08386
362242008155	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
362242008156	putative active site [active]
362242008157	DivIVA domain; Region: DivI1A_domain; TIGR03544
362242008158	Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599
362242008159	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
362242008160	Predicted integral membrane protein [Function unknown]; Region: COG0762
362242008161	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799
362242008162	Predicted enzyme with a TIM-barrel fold [General function prediction only]; Region: COG0325
362242008163	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
362242008164	catalytic residue [active]
362242008165	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
362242008166	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
362242008167	cell division protein FtsZ; Validated; Region: PRK09330
362242008168	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
362242008169	nucleotide binding site [chemical binding]; other site
362242008170	SulA interaction site; other site
362242008171	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
362242008172	Cell division protein FtsQ; Region: FtsQ; pfam03799
362242008173	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
362242008174	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
362242008175	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
362242008176	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
362242008177	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
362242008178	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
362242008179	active site
362242008180	homodimer interface [polypeptide binding]; other site
362242008181	cell division protein FtsW; Region: ftsW; TIGR02614
362242008182	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03369
362242008183	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
362242008184	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
362242008185	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
362242008186	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
362242008187	Mg++ binding site [ion binding]; other site
362242008188	putative catalytic motif [active]
362242008189	putative substrate binding site [chemical binding]; other site
362242008190	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
362242008191	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
362242008192	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
362242008193	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
362242008194	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
362242008195	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
362242008196	PE family; Region: PE; pfam00934
362242008199	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
362242008200	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
362242008201	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
362242008202	Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275
362242008203	MraW methylase family; Region: Methyltransf_5; cl17771
362242008204	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001
362242008205	MraZ protein; Region: MraZ; pfam02381
362242008206	MraZ protein; Region: MraZ; pfam02381
362242008207	Protein of unknown function (DUF3040); Region: DUF3040; pfam11239
362242008208	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
362242008209	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
362242008210	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
362242008211	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
362242008212	substrate binding pocket [chemical binding]; other site
362242008213	chain length determination region; other site
362242008214	substrate-Mg2+ binding site; other site
362242008215	catalytic residues [active]
362242008216	aspartate-rich region 1; other site
362242008217	active site lid residues [active]
362242008218	aspartate-rich region 2; other site
362242008219	carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459
362242008220	Helix-turn-helix domain; Region: HTH_17; cl17695
362242008221	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
362242008222	Catalytic domain of Protein Kinases; Region: PKc; cd00180
362242008223	active site
362242008224	ATP binding site [chemical binding]; other site
362242008225	substrate binding site [chemical binding]; other site
362242008226	activation loop (A-loop); other site
362242008227	Transposase, Mutator family; Region: Transposase_mut; pfam00872
362242008228	MULE transposase domain; Region: MULE; pfam10551
362242008229	Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase; cl00205
362242008230	homodimer interface [polypeptide binding]; other site
362242008231	substrate binding pocket [chemical binding]; other site
362242008232	catalytic residues [active]
362242008233	NADH/NADPH cofactor binding site [chemical binding]; other site
362242008234	phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220
362242008235	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
362242008236	diphosphomevalonate decarboxylase; Region: PLN02407
362242008237	mevalonate kinase; Region: mevalon_kin; TIGR00549
362242008238	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
362242008239	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242008240	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242008241	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242008242	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
362242008243	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
362242008244	dimer interface [polypeptide binding]; other site
362242008245	active site
362242008246	CoA binding pocket [chemical binding]; other site
362242008247	Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474
362242008248	Protein of unknown function (DUF2029); Region: DUF2029; pfam09594
362242008249	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
362242008250	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
362242008251	putative acyl-acceptor binding pocket; other site
362242008252	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
362242008253	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
362242008254	DTAP/Switch II; other site
362242008255	Switch I; other site
362242008256	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819
362242008257	putative hydrophobic ligand binding site [chemical binding]; other site
362242008258	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
362242008259	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
362242008260	acyl-activating enzyme (AAE) consensus motif; other site
362242008261	putative AMP binding site [chemical binding]; other site
362242008262	putative active site [active]
362242008263	putative CoA binding site [chemical binding]; other site
362242008264	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
362242008265	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
362242008266	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
362242008267	NlpC/P60 family; Region: NLPC_P60; pfam00877
362242008268	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
362242008269	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
362242008270	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
362242008271	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386
362242008272	Subunit I/III interface [polypeptide binding]; other site
362242008273	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
362242008274	Cytochrome c; Region: Cytochrom_C; pfam00034
362242008275	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
362242008276	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
362242008277	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
362242008278	iron-sulfur cluster [ion binding]; other site
362242008279	[2Fe-2S] cluster binding site [ion binding]; other site
362242008280	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
362242008281	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
362242008282	heme bH binding site [chemical binding]; other site
362242008283	intrachain domain interface; other site
362242008284	heme bL binding site [chemical binding]; other site
362242008285	interchain domain interface [polypeptide binding]; other site
362242008286	Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631
362242008287	Qo binding site; other site
362242008288	Protein of unknown function (DUF2561); Region: DUF2561; pfam10812
362242008289	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
362242008290	Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270
362242008291	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
362242008292	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
362242008293	Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367
362242008294	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
362242008295	dimer interface [polypeptide binding]; other site
362242008296	active site
362242008297	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
362242008298	Ligand Binding Site [chemical binding]; other site
362242008299	Molecular Tunnel; other site
362242008300	Ribokinase-like subgroup A.  Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942
362242008301	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
362242008302	substrate binding site [chemical binding]; other site
362242008303	ATP binding site [chemical binding]; other site
362242008304	Iron-sulfur cluster assembly accessory protein; Region: TIGR00049
362242008305	Glycerate kinase family; Region: Gly_kinase; pfam02595
362242008306	Protein of unknown function (DUF3043); Region: DUF3043; pfam11241
362242008307	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
362242008308	homotrimer interface [polypeptide binding]; other site
362242008309	Walker A motif; other site
362242008310	GTP binding site [chemical binding]; other site
362242008311	Walker B motif; other site
362242008312	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
362242008313	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
362242008314	active site pocket [active]
362242008315	putative dimer interface [polypeptide binding]; other site
362242008316	putative cataytic base [active]
362242008317	cobalamin synthase; Reviewed; Region: cobS; PRK00235
362242008318	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242008319	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242008320	MFS/sugar transport protein; Region: MFS_2; pfam13347
362242008321	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
362242008322	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
362242008323	homodimer interface [polypeptide binding]; other site
362242008324	substrate-cofactor binding pocket; other site
362242008325	catalytic residue [active]
362242008326	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
362242008327	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
362242008328	multifunctional aminopeptidase A; Provisional; Region: PRK00913
362242008329	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
362242008330	interface (dimer of trimers) [polypeptide binding]; other site
362242008331	Substrate-binding/catalytic site; other site
362242008332	Zn-binding sites [ion binding]; other site
362242008333	short chain dehydrogenase; Validated; Region: PRK05855
362242008334	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
362242008335	classical (c) SDRs; Region: SDR_c; cd05233
362242008336	NAD(P) binding site [chemical binding]; other site
362242008337	active site
362242008338	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
362242008339	E3 interaction surface; other site
362242008340	lipoyl attachment site [posttranslational modification]; other site
362242008341	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
362242008342	E3 interaction surface; other site
362242008343	lipoyl attachment site [posttranslational modification]; other site
362242008344	e3 binding domain; Region: E3_binding; pfam02817
362242008345	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857
362242008346	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
362242008347	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
362242008348	atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242
362242008349	putative NAD(P) binding site [chemical binding]; other site
362242008350	putative active site [active]
362242008351	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
362242008352	daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
362242008353	Walker A/P-loop; other site
362242008354	ATP binding site [chemical binding]; other site
362242008355	Q-loop/lid; other site
362242008356	ABC transporter signature motif; other site
362242008357	Walker B; other site
362242008358	D-loop; other site
362242008359	H-loop/switch region; other site
362242008360	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242008361	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242008362	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242008363	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
362242008364	Lumazine-binding domain; Region: Lumazine_bd; pfam12870
362242008365	SnoaL-like domain; Region: SnoaL_3; pfam13474
362242008366	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242008367	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242008368	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242008369	Interferon-induced transmembrane protein; Region: CD225; pfam04505
362242008370	Protein of unknown function (DUF2752); Region: DUF2752; pfam10825
362242008371	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
362242008372	PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH.  Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816
362242008373	PA/protease or protease-like domain interface [polypeptide binding]; other site
362242008374	M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876
362242008375	Peptidase family M28; Region: Peptidase_M28; pfam04389
362242008376	active site
362242008377	metal binding site [ion binding]; metal-binding site
362242008378	Predicted metalloprotease [General function prediction only]; Region: COG2321
362242008379	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
362242008380	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
362242008381	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
362242008382	putative substrate translocation pore; other site
362242008383	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
362242008384	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
362242008385	ligand binding site [chemical binding]; other site
362242008386	flexible hinge region; other site
362242008387	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
362242008388	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
362242008389	active site
362242008390	nucleophile elbow; other site
362242008391	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242008392	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242008393	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242008394	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242008395	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242008396	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242008397	Response regulator receiver domain; Region: Response_reg; pfam00072
362242008398	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
362242008399	active site
362242008400	phosphorylation site [posttranslational modification]
362242008401	intermolecular recognition site; other site
362242008402	dimerization interface [polypeptide binding]; other site
362242008403	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
362242008404	cyclase homology domain; Region: CHD; cd07302
362242008405	nucleotidyl binding site; other site
362242008406	metal binding site [ion binding]; metal-binding site
362242008407	dimer interface [polypeptide binding]; other site
362242008408	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
362242008409	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
362242008410	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
362242008411	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
362242008412	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
362242008413	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
362242008414	dimer interface [polypeptide binding]; other site
362242008415	substrate binding site [chemical binding]; other site
362242008416	ATP binding site [chemical binding]; other site
362242008417	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
362242008418	ThiC-associated domain; Region: ThiC-associated; pfam13667
362242008419	ThiC family; Region: ThiC; pfam01964
362242008420	PAS fold; Region: PAS_3; pfam08447
362242008421	ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012
362242008422	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
362242008423	anti sigma factor interaction site; other site
362242008424	regulatory phosphorylation site [posttranslational modification]; other site
362242008425	Transposase, Mutator family; Region: Transposase_mut; pfam00872
362242008426	MULE transposase domain; Region: MULE; pfam10551
362242008427	Transposase, Mutator family; Region: Transposase_mut; pfam00872
362242008428	MULE transposase domain; Region: MULE; pfam10551
362242008429	glycyl-tRNA synthetase; Provisional; Region: PRK04173
362242008430	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
362242008431	motif 1; other site
362242008432	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774
362242008433	active site
362242008434	motif 2; other site
362242008435	motif 3; other site
362242008436	GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
362242008437	anticodon binding site; other site
362242008438	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
362242008439	dimerization interface [polypeptide binding]; other site
362242008440	putative DNA binding site [nucleotide binding]; other site
362242008441	putative Zn2+ binding site [ion binding]; other site
362242008442	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
362242008443	metal binding site 2 [ion binding]; metal-binding site
362242008444	putative DNA binding helix; other site
362242008445	metal binding site 1 [ion binding]; metal-binding site
362242008446	dimer interface [polypeptide binding]; other site
362242008447	structural Zn2+ binding site [ion binding]; other site
362242008448	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
362242008449	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
362242008450	catalytic residue [active]
362242008451	putative FPP diphosphate  binding site; other site
362242008452	putative FPP binding hydrophobic cleft; other site
362242008453	dimer interface [polypeptide binding]; other site
362242008454	putative IPP diphosphate binding site; other site
362242008455	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
362242008456	Recombination protein O N terminal; Region: RecO_N; pfam11967
362242008457	Recombination protein O C terminal; Region: RecO_C; pfam02565
362242008458	amidase; Provisional; Region: PRK06061
362242008459	Amidase; Region: Amidase; pfam01425
362242008460	GTPase Era; Reviewed; Region: era; PRK00089
362242008461	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
362242008462	G1 box; other site
362242008463	GTP/Mg2+ binding site [chemical binding]; other site
362242008464	Switch I region; other site
362242008465	G2 box; other site
362242008466	Switch II region; other site
362242008467	G3 box; other site
362242008468	G4 box; other site
362242008469	G5 box; other site
362242008470	KH domain; Region: KH_2; pfam07650
362242008471	metal-binding heat shock protein; Provisional; Region: PRK00016
362242008472	K homology RNA-binding domain; Region: KH; smart00322
362242008473	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
362242008474	PhoH-like protein; Region: PhoH; pfam02562
362242008475	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
362242008476	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
362242008477	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385
362242008478	RNA methyltransferase, RsmE family; Region: TIGR00046
362242008479	chaperone protein DnaJ; Provisional; Region: PRK14278
362242008480	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
362242008481	HSP70 interaction site [polypeptide binding]; other site
362242008482	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
362242008483	Zn binding sites [ion binding]; other site
362242008484	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
362242008485	dimer interface [polypeptide binding]; other site
362242008486	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
362242008487	HTH domain; Region: HTH_11; cl17392
362242008488	Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450
362242008489	Uncharacterized conserved protein [Function unknown]; Region: COG2128
362242008490	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
362242008491	RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636
362242008492	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
362242008493	Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433
362242008494	Condensation domain; Region: Condensation; pfam00668
362242008495	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
362242008496	Nonribosomal peptide synthase; Region: NRPS; pfam08415
362242008497	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114
362242008498	acyl-activating enzyme (AAE) consensus motif; other site
362242008499	AMP binding site [chemical binding]; other site
362242008500	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
362242008501	Condensation domain; Region: Condensation; pfam00668
362242008502	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
362242008503	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
362242008504	acyl-activating enzyme (AAE) consensus motif; other site
362242008505	AMP binding site [chemical binding]; other site
362242008506	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
362242008507	Condensation domain; Region: Condensation; pfam00668
362242008508	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
362242008509	Condensation domain; Region: Condensation; pfam00668
362242008510	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
362242008511	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
362242008512	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
362242008513	acyl-activating enzyme (AAE) consensus motif; other site
362242008514	AMP binding site [chemical binding]; other site
362242008515	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
362242008516	Condensation domain; Region: Condensation; pfam00668
362242008517	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
362242008518	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
362242008519	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
362242008520	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
362242008521	Siderophore biosynthesis protein domain; Region: AlcB; smart01006
362242008522	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
362242008523	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
362242008524	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
362242008525	active site
362242008526	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
362242008527	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
362242008528	ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274
362242008529	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
362242008530	NADP binding site [chemical binding]; other site
362242008531	active site
362242008532	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
362242008533	MbtH-like protein; Region: MbtH; pfam03621
362242008534	L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434
362242008535	Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021
362242008536	2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920
362242008537	acyl-activating enzyme (AAE) consensus motif; other site
362242008538	active site
362242008539	AMP binding site [chemical binding]; other site
362242008540	substrate binding site [chemical binding]; other site
362242008541	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
362242008542	short chain dehydrogenase; Provisional; Region: PRK07832
362242008543	classical (c) SDRs; Region: SDR_c; cd05233
362242008544	NAD(P) binding site [chemical binding]; other site
362242008545	active site
362242008546	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
362242008547	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
362242008548	Fatty acid desaturase; Region: FA_desaturase_2; pfam03405
362242008549	Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050
362242008550	homodimer interface [polypeptide binding]; other site
362242008551	putative substrate binding pocket [chemical binding]; other site
362242008552	diiron center [ion binding]; other site
362242008553	salicylate synthase MbtI; Reviewed; Region: PRK07912
362242008554	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
362242008555	Predicted permease [General function prediction only]; Region: COG3329
362242008556	coproporphyrinogen III oxidase; Validated; Region: PRK05628
362242008557	Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
362242008558	active site
362242008559	HemN C-terminal domain; Region: HemN_C; pfam06969
362242008560	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
362242008561	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
362242008562	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
362242008563	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
362242008564	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
362242008565	Active Sites [active]
362242008566	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
362242008567	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
362242008568	putative active site [active]
362242008569	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414
362242008570	putative active site [active]
362242008571	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
362242008572	sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968
362242008573	Walker A/P-loop; other site
362242008574	ATP binding site [chemical binding]; other site
362242008575	Q-loop/lid; other site
362242008576	ABC transporter signature motif; other site
362242008577	Walker B; other site
362242008578	D-loop; other site
362242008579	H-loop/switch region; other site
362242008580	TOBE domain; Region: TOBE; pfam03459
362242008581	sulfate transport protein; Provisional; Region: cysT; CHL00187
362242008582	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
362242008583	dimer interface [polypeptide binding]; other site
362242008584	conserved gate region; other site
362242008585	putative PBP binding loops; other site
362242008586	ABC-ATPase subunit interface; other site
362242008587	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
362242008588	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
362242008589	dimer interface [polypeptide binding]; other site
362242008590	conserved gate region; other site
362242008591	putative PBP binding loops; other site
362242008592	ABC-ATPase subunit interface; other site
362242008593	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
362242008594	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
362242008595	hypothetical protein; Provisional; Region: PRK06185
362242008596	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
362242008597	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
362242008598	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
362242008599	PknH-like extracellular domain; Region: PknH_C; pfam14032
362242008600	PknH-like extracellular domain; Region: PknH_C; pfam14032
362242008601	GTP-binding protein LepA; Provisional; Region: PRK05433
362242008602	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
362242008603	putative GEF interaction site [polypeptide binding]; other site
362242008604	Switch I region; other site
362242008605	G2 box; other site
362242008606	G3 box; other site
362242008607	Switch II region; other site
362242008608	GTP/Mg2+ binding site [chemical binding]; other site
362242008609	G4 box; other site
362242008610	G5 box; other site
362242008611	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
362242008612	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
362242008613	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
362242008614	PemK-like protein; Region: PemK; pfam02452
362242008615	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623
362242008616	FOG: CBS domain [General function prediction only]; Region: COG0517
362242008617	ribonuclease Z; Reviewed; Region: PRK00055
362242008618	PE family; Region: PE; pfam00934
362242008620	PE family; Region: PE; pfam00934
362242008622	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
362242008623	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
362242008624	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
362242008625	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
362242008626	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
362242008627	Uncharacterized conserved protein [Function unknown]; Region: COG2308
362242008628	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
362242008629	hypothetical protein; Reviewed; Region: PRK07914
362242008630	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
362242008631	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242008632	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242008633	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242008634	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
362242008635	Competence protein; Region: Competence; cl00471
362242008636	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
362242008637	Helix-hairpin-helix motif; Region: HHH; pfam00633
362242008638	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
362242008639	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
362242008640	active site
362242008641	pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203
362242008642	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
362242008643	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
362242008644	active site
362242008645	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
362242008646	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
362242008647	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
362242008648	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
362242008649	EDD domain protein, DegV family; Region: DegV; TIGR00762
362242008650	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
362242008651	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
362242008652	active site
362242008653	catalytic triad [active]
362242008654	oxyanion hole [active]
362242008655	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
362242008656	catalytic core [active]
362242008657	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
362242008658	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
362242008659	active site
362242008660	(T/H)XGH motif; other site
362242008661	Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799
362242008662	Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552
362242008663	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
362242008664	metal ion-dependent adhesion site (MIDAS); other site
362242008665	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
362242008666	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
362242008667	Walker A motif; other site
362242008668	ATP binding site [chemical binding]; other site
362242008669	Walker B motif; other site
362242008670	arginine finger; other site
362242008671	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
362242008672	putative catalytic cysteine [active]
362242008673	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
362242008674	Mechanosensitive ion channel; Region: MS_channel; pfam00924
362242008675	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
362242008676	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
362242008677	ligand binding site [chemical binding]; other site
362242008678	flexible hinge region; other site
362242008679	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
362242008680	dimerization interface [polypeptide binding]; other site
362242008681	Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044
362242008682	cyclase homology domain; Region: CHD; cd07302
362242008683	nucleotidyl binding site; other site
362242008684	metal binding site [ion binding]; metal-binding site
362242008685	dimer interface [polypeptide binding]; other site
362242008686	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
362242008687	Mechanosensitive ion channel; Region: MS_channel; pfam00924
362242008688	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
362242008689	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
362242008690	ligand binding site [chemical binding]; other site
362242008691	flexible hinge region; other site
362242008692	Transposase, Mutator family; Region: Transposase_mut; pfam00872
362242008693	MULE transposase domain; Region: MULE; pfam10551
362242008694	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242008695	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242008696	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242008697	PE family; Region: PE; pfam00934
362242008699	NAD synthetase; Reviewed; Region: nadE; PRK02628
362242008700	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
362242008701	multimer interface [polypeptide binding]; other site
362242008702	active site
362242008703	catalytic triad [active]
362242008704	protein interface 1 [polypeptide binding]; other site
362242008705	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
362242008706	homodimer interface [polypeptide binding]; other site
362242008707	NAD binding pocket [chemical binding]; other site
362242008708	ATP binding pocket [chemical binding]; other site
362242008709	Mg binding site [ion binding]; other site
362242008710	active-site loop [active]
362242008711	NAD-dependent deacetylase; Provisional; Region: PRK00481
362242008712	SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein...; Region: SIRT4; cd01409
362242008713	NAD+ binding site [chemical binding]; other site
362242008714	substrate binding site [chemical binding]; other site
362242008715	Zn binding site [ion binding]; other site
362242008716	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
362242008717	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
362242008720	gamma-glutamyl kinase; Provisional; Region: PRK05429
362242008721	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
362242008722	nucleotide binding site [chemical binding]; other site
362242008723	homotetrameric interface [polypeptide binding]; other site
362242008724	putative phosphate binding site [ion binding]; other site
362242008725	putative allosteric binding site; other site
362242008726	PUA domain; Region: PUA; pfam01472
362242008727	GTPase CgtA; Reviewed; Region: obgE; PRK12296
362242008728	GTP1/OBG; Region: GTP1_OBG; pfam01018
362242008729	Obg GTPase; Region: Obg; cd01898
362242008730	G1 box; other site
362242008731	GTP/Mg2+ binding site [chemical binding]; other site
362242008732	Switch I region; other site
362242008733	G2 box; other site
362242008734	G3 box; other site
362242008735	Switch II region; other site
362242008736	G4 box; other site
362242008737	G5 box; other site
362242008738	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
362242008739	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
362242008740	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
362242008741	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
362242008742	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
362242008743	homodimer interface [polypeptide binding]; other site
362242008744	oligonucleotide binding site [chemical binding]; other site
362242008746	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
362242008747	active site
362242008748	multimer interface [polypeptide binding]; other site
362242008749	Protein of unknown function (DUF4233); Region: DUF4233; pfam14017
362242008750	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
362242008751	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
362242008752	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
362242008753	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
362242008754	active site
362242008755	HIGH motif; other site
362242008756	nucleotide binding site [chemical binding]; other site
362242008757	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
362242008758	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
362242008759	active site
362242008760	KMSKS motif; other site
362242008761	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
362242008762	tRNA binding surface [nucleotide binding]; other site
362242008763	anticodon binding site; other site
362242008764	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
362242008765	Bulb-type mannose-specific lectin; Region: B_lectin; smart00108
362242008766	Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically...; Region: B_lectin; cd00028
362242008767	dimerization interface [polypeptide binding]; other site
362242008768	mannose binding site [chemical binding]; other site
362242008769	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
362242008770	Bacterial protein of unknown function (DUF937); Region: DUF937; pfam06078
362242008771	Uncharacterized conserved protein [Function unknown]; Region: COG3268
362242008772	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
362242008773	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
362242008775	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
362242008776	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
362242008777	GTP binding site; other site
362242008778	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867
362242008779	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
362242008780	TPP-binding site [chemical binding]; other site
362242008781	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
362242008782	2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710
362242008783	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
362242008784	dimer interface [polypeptide binding]; other site
362242008785	PYR/PP interface [polypeptide binding]; other site
362242008786	TPP binding site [chemical binding]; other site
362242008787	substrate binding site [chemical binding]; other site
362242008788	Major Facilitator Superfamily; Region: MFS_1; pfam07690
362242008789	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
362242008790	putative substrate translocation pore; other site
362242008791	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
362242008792	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
362242008793	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
362242008794	Walker A motif; other site
362242008795	ATP binding site [chemical binding]; other site
362242008796	Walker B motif; other site
362242008797	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
362242008798	methyl viologen resistance protein SmvA; Provisional; Region: PRK14995
362242008799	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
362242008800	putative substrate translocation pore; other site
362242008801	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
362242008802	ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553
362242008803	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
362242008804	oligomer interface [polypeptide binding]; other site
362242008805	active site residues [active]
362242008806	Clp protease; Region: CLP_protease; pfam00574
362242008807	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
362242008808	oligomer interface [polypeptide binding]; other site
362242008809	active site residues [active]
362242008810	trigger factor; Provisional; Region: tig; PRK01490
362242008811	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
362242008812	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
362242008813	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
362242008814	Beta-lactamase; Region: Beta-lactamase; pfam00144
362242008815	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
362242008816	N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970
362242008817	putative DNA binding site [nucleotide binding]; other site
362242008818	catalytic residue [active]
362242008819	putative H2TH interface [polypeptide binding]; other site
362242008820	putative catalytic residues [active]
362242008821	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
362242008822	ribose-5-phosphate isomerase B; Provisional; Region: PRK05571
362242008823	PE family; Region: PE; pfam00934
362242008824	aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412
362242008825	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602
362242008826	Zn binding site [ion binding]; other site
362242008827	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
362242008828	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
362242008829	active site
362242008830	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
362242008831	apolar tunnel; other site
362242008832	heme binding site [chemical binding]; other site
362242008833	dimerization interface [polypeptide binding]; other site
362242008834	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
362242008835	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
362242008836	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242008837	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242008838	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
362242008839	active site
362242008840	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
362242008841	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
362242008842	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
362242008843	ABC transporter; Region: ABC_tran_2; pfam12848
362242008844	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
362242008845	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
362242008846	dimer interface [polypeptide binding]; other site
362242008847	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
362242008848	ssDNA binding site [nucleotide binding]; other site
362242008849	tetramer (dimer of dimers) interface [polypeptide binding]; other site
362242008850	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
362242008851	HAD-superfamily subfamily IB hydrolase, TIGR01490; Region: HAD-SF-IB-hyp1
362242008852	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
362242008853	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
362242008854	putative acyl-acceptor binding pocket; other site
362242008855	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
362242008856	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
362242008857	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
362242008858	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
362242008859	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
362242008860	cobyric acid synthase; Provisional; Region: PRK00784
362242008861	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
362242008862	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
362242008863	catalytic triad [active]
362242008864	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
362242008865	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
362242008866	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
362242008867	S-adenosylmethionine binding site [chemical binding]; other site
362242008868	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
362242008869	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
362242008870	E3 interaction surface; other site
362242008871	lipoyl attachment site [posttranslational modification]; other site
362242008872	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
362242008873	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
362242008874	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
362242008875	alpha subunit interface [polypeptide binding]; other site
362242008876	TPP binding site [chemical binding]; other site
362242008877	heterodimer interface [polypeptide binding]; other site
362242008878	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
362242008879	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
362242008880	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
362242008881	tetramer interface [polypeptide binding]; other site
362242008882	TPP-binding site [chemical binding]; other site
362242008883	heterodimer interface [polypeptide binding]; other site
362242008884	phosphorylation loop region [posttranslational modification]
362242008885	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
362242008886	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
362242008887	putative active site [active]
362242008888	putative catalytic site [active]
362242008889	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
362242008890	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
362242008891	active site
362242008892	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
362242008893	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
362242008894	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
362242008895	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
362242008896	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
362242008897	carboxyltransferase (CT) interaction site; other site
362242008898	biotinylation site [posttranslational modification]; other site
362242008899	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
362242008900	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
362242008901	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242008902	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242008903	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242008904	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
362242008905	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
362242008906	Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270
362242008907	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
362242008908	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
362242008909	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
362242008910	NAD(P) binding site [chemical binding]; other site
362242008911	active site
362242008912	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
362242008913	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
362242008914	catalytic site [active]
362242008915	putative active site [active]
362242008916	putative substrate binding site [chemical binding]; other site
362242008917	dimer interface [polypeptide binding]; other site
362242008918	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
362242008919	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
362242008920	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
362242008921	Permease; Region: Permease; pfam02405
362242008922	mce related protein; Region: MCE; pfam02470
362242008923	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
362242008924	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
362242008925	mce related protein; Region: MCE; pfam02470
362242008926	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
362242008927	mce related protein; Region: MCE; pfam02470
362242008928	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
362242008929	mce related protein; Region: MCE; pfam02470
362242008930	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
362242008931	mce related protein; Region: MCE; pfam02470
362242008932	Mannan-binding protein; Region: MVL; pfam12151
362242008933	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431
362242008934	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
362242008935	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432
362242008936	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
362242008937	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
362242008938	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
362242008939	putative acyl-acceptor binding pocket; other site
362242008940	Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077
362242008941	Protein of unknown function (DUF3618); Region: DUF3618; pfam12277
362242008942	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
362242008943	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
362242008944	catalytic triad [active]
362242008945	hypothetical protein; Provisional; Region: PRK07907
362242008946	M20 Dipeptidases; Region: M20_Dipept_like; cd03893
362242008947	active site
362242008948	metal binding site [ion binding]; metal-binding site
362242008949	dimer interface [polypeptide binding]; other site
362242008950	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
362242008951	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
362242008952	active site
362242008953	phosphorylation site [posttranslational modification]
362242008954	intermolecular recognition site; other site
362242008955	dimerization interface [polypeptide binding]; other site
362242008956	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
362242008957	DNA binding residues [nucleotide binding]
362242008958	dimerization interface [polypeptide binding]; other site
362242008959	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
362242008960	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
362242008961	Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981
362242008962	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
362242008963	phosphate binding site [ion binding]; other site
362242008964	Domain of unknown function (DUF1729); Region: DUF1729; pfam08354
362242008965	FAS_MaoC, the MaoC-like hot dog fold of the fatty acid synthase, beta subunit.  Other enzymes with this fold include MaoC dehydratase, Hydratase-Dehydrogenase-Epimerase protein (HDE), and 17-beta-hydroxysteriod dehydrogenase (HSD); Region: FAS_MaoC; cd03447
362242008966	putative active site [active]
362242008967	putative catalytic site [active]
362242008968	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
362242008969	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
362242008970	3-oxoacyl-[acyl-carrier protein]; Region: COG4982
362242008971	ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950
362242008972	putative NAD(P) binding site [chemical binding]; other site
362242008973	active site
362242008974	"elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828
362242008975	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
362242008976	active site
362242008977	TAT (twin-arginine translocation) pathway signal sequence; Region: TAT_signal; pfam10518
362242008978	Domain of unknown function (DUF1906); Region: DUF1906; pfam08924
362242008979	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
362242008980	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
362242008981	[2Fe-2S] cluster binding site [ion binding]; other site
362242008982	C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_3; cd08887
362242008983	putative alpha subunit interface [polypeptide binding]; other site
362242008984	putative active site [active]
362242008985	putative substrate binding site [chemical binding]; other site
362242008986	Fe binding site [ion binding]; other site
362242008987	SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  The alpha- and...; Region: SAV4209; cd03455
362242008988	putative active site [active]
362242008989	putative catalytic site [active]
362242008990	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
362242008991	active site 2 [active]
362242008992	active site 1 [active]
362242008993	SnoaL-like domain; Region: SnoaL_4; pfam13577
362242008994	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
362242008995	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
362242008996	putative substrate translocation pore; other site
362242008997	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
362242008999	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242009000	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242009001	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242009002	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
362242009004	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
362242009005	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
362242009006	[2Fe-2S] cluster binding site [ion binding]; other site
362242009007	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
362242009008	hydrophobic ligand binding site; other site
362242009009	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
362242009010	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
362242009011	Transcriptional regulators [Transcription]; Region: FadR; COG2186
362242009012	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
362242009013	DNA-binding site [nucleotide binding]; DNA binding site
362242009014	FCD domain; Region: FCD; pfam07729
362242009015	Transposase, Mutator family; Region: Transposase_mut; pfam00872
362242009016	MULE transposase domain; Region: MULE; pfam10551
362242009017	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242009018	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242009019	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242009020	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242009021	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242009022	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242009023	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
362242009024	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
362242009025	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
362242009026	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
362242009027	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
362242009028	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
362242009029	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
362242009030	active site
362242009031	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
362242009032	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
362242009033	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
362242009034	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
362242009035	putative AMP binding site [chemical binding]; other site
362242009036	putative active site [active]
362242009037	acyl-activating enzyme (AAE) consensus motif; other site
362242009038	acyl-activating enzyme (AAE) consensus motif; other site
362242009039	putative CoA binding site [chemical binding]; other site
362242009040	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
362242009041	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
362242009042	putative sugar binding sites [chemical binding]; other site
362242009043	Q-X-W motif; other site
362242009044	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
362242009045	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
362242009046	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
362242009047	CoenzymeA binding site [chemical binding]; other site
362242009048	subunit interaction site [polypeptide binding]; other site
362242009049	PHB binding site; other site
362242009050	Amidohydrolase; Region: Amidohydro_2; pfam04909
362242009052	PAS fold; Region: PAS_4; pfam08448
362242009053	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
362242009054	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
362242009055	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
362242009056	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
362242009057	anti sigma factor interaction site; other site
362242009058	regulatory phosphorylation site [posttranslational modification]; other site
362242009059	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
362242009060	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
362242009061	active site
362242009062	type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348
362242009063	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
362242009064	Cytochrome P450; Region: p450; cl12078
362242009065	oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989
362242009066	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
362242009067	NAD binding site [chemical binding]; other site
362242009068	catalytic Zn binding site [ion binding]; other site
362242009069	substrate binding site [chemical binding]; other site
362242009070	structural Zn binding site [ion binding]; other site
362242009071	short chain dehydrogenase; Provisional; Region: PRK06197
362242009072	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
362242009073	putative NAD(P) binding site [chemical binding]; other site
362242009074	active site
362242009075	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
362242009076	Cytochrome P450; Region: p450; cl12078
362242009077	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
362242009078	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
362242009079	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
362242009080	short chain dehydrogenase; Validated; Region: PRK06182
362242009081	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
362242009082	NAD(P) binding site [chemical binding]; other site
362242009083	active site
362242009084	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
362242009085	probable F420-dependent oxidoreductase, MSMEG_2249 family; Region: F420_MSMEG_2249; TIGR03857
362242009086	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
362242009087	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
362242009088	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
362242009089	CoenzymeA binding site [chemical binding]; other site
362242009090	subunit interaction site [polypeptide binding]; other site
362242009091	PHB binding site; other site
362242009092	acyl-CoA synthetase; Validated; Region: PRK07798
362242009093	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
362242009094	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924
362242009095	acyl-activating enzyme (AAE) consensus motif; other site
362242009096	acyl-activating enzyme (AAE) consensus motif; other site
362242009097	putative AMP binding site [chemical binding]; other site
362242009098	putative active site [active]
362242009099	putative CoA binding site [chemical binding]; other site
362242009100	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242009101	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242009102	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242009103	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
362242009104	Cytochrome P450; Region: p450; cl12078
362242009105	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
362242009106	CoA-transferase family III; Region: CoA_transf_3; pfam02515
362242009107	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
362242009108	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
362242009109	active site
362242009110	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
362242009111	Amidohydrolase; Region: Amidohydro_2; pfam04909
362242009112	enoyl-CoA hydratase; Provisional; Region: PRK06210
362242009113	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
362242009114	substrate binding site [chemical binding]; other site
362242009115	oxyanion hole (OAH) forming residues; other site
362242009116	trimer interface [polypeptide binding]; other site
362242009117	tetracycline repressor protein TetR; Provisional; Region: PRK13756
362242009118	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
362242009119	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
362242009120	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
362242009121	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
362242009122	substrate binding site [chemical binding]; other site
362242009123	oxyanion hole (OAH) forming residues; other site
362242009124	trimer interface [polypeptide binding]; other site
362242009125	enoyl-CoA hydratase; Provisional; Region: PRK06688
362242009126	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
362242009127	substrate binding site [chemical binding]; other site
362242009128	oxyanion hole (OAH) forming residues; other site
362242009129	trimer interface [polypeptide binding]; other site
362242009130	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
362242009131	enoyl-CoA hydratase; Provisional; Region: PRK06494
362242009132	substrate binding site [chemical binding]; other site
362242009133	oxyanion hole (OAH) forming residues; other site
362242009134	trimer interface [polypeptide binding]; other site
362242009135	enoyl-CoA hydratase; Provisional; Region: PRK05980
362242009136	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
362242009137	substrate binding site [chemical binding]; other site
362242009138	oxyanion hole (OAH) forming residues; other site
362242009139	trimer interface [polypeptide binding]; other site
362242009140	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
362242009141	AMP-binding enzyme; Region: AMP-binding; pfam00501
362242009142	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
362242009143	acyl-activating enzyme (AAE) consensus motif; other site
362242009144	acyl-activating enzyme (AAE) consensus motif; other site
362242009145	AMP binding site [chemical binding]; other site
362242009146	active site
362242009147	CoA binding site [chemical binding]; other site
362242009148	Transcriptional regulators [Transcription]; Region: GntR; COG1802
362242009149	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
362242009150	DNA-binding site [nucleotide binding]; DNA binding site
362242009151	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
362242009152	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
362242009153	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
362242009154	active site
362242009155	mesaconyl-CoA isomerase; Region: mesacon_CoA_iso; TIGR04253
362242009156	CoA-transferase family III; Region: CoA_transf_3; pfam02515
362242009157	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
362242009158	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
362242009159	NAD(P) binding site [chemical binding]; other site
362242009160	active site
362242009161	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
362242009162	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
362242009163	Walker A/P-loop; other site
362242009164	ATP binding site [chemical binding]; other site
362242009165	Q-loop/lid; other site
362242009166	ABC transporter signature motif; other site
362242009167	Walker B; other site
362242009168	D-loop; other site
362242009169	H-loop/switch region; other site
362242009170	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
362242009171	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
362242009172	FAD binding pocket [chemical binding]; other site
362242009173	FAD binding motif [chemical binding]; other site
362242009174	phosphate binding motif [ion binding]; other site
362242009175	NAD binding pocket [chemical binding]; other site
362242009176	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
362242009177	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
362242009178	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
362242009179	Walker A/P-loop; other site
362242009180	ATP binding site [chemical binding]; other site
362242009181	Q-loop/lid; other site
362242009182	ABC transporter signature motif; other site
362242009183	Walker B; other site
362242009184	D-loop; other site
362242009185	H-loop/switch region; other site
362242009186	Glucitol operon activator protein (GutM); Region: GutM; cl01890
362242009187	Domain of unknown function (DUF3817); Region: DUF3817; pfam12823
362242009188	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
362242009189	active site
362242009190	dimerization interface [polypeptide binding]; other site
362242009191	Domain of unknown function (DUF4395); Region: DUF4395; pfam14340
362242009192	ribonuclease PH; Reviewed; Region: rph; PRK00173
362242009193	Ribonuclease PH; Region: RNase_PH_bact; cd11362
362242009194	hexamer interface [polypeptide binding]; other site
362242009195	active site
362242009196	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
362242009197	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
362242009198	TPP-binding site [chemical binding]; other site
362242009199	Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861
362242009200	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
362242009201	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
362242009202	dimerization interface [polypeptide binding]; other site
362242009203	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
362242009204	putative DNA binding site [nucleotide binding]; other site
362242009205	putative Zn2+ binding site [ion binding]; other site
362242009206	AsnC family; Region: AsnC_trans_reg; pfam01037
362242009207	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
362242009208	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
362242009209	Permease; Region: Permease; pfam02405
362242009210	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
362242009211	Permease; Region: Permease; pfam02405
362242009212	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
362242009213	mce related protein; Region: MCE; pfam02470
362242009214	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
362242009215	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
362242009216	mce related protein; Region: MCE; pfam02470
362242009217	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
362242009218	mce related protein; Region: MCE; pfam02470
362242009219	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
362242009220	mce related protein; Region: MCE; pfam02470
362242009221	mce related protein; Region: MCE; pfam02470
362242009222	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
362242009223	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
362242009224	mce related protein; Region: MCE; pfam02470
362242009225	glutamate racemase; Provisional; Region: PRK00865
362242009226	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
362242009227	MoaE interaction surface [polypeptide binding]; other site
362242009228	MoeB interaction surface [polypeptide binding]; other site
362242009229	thiocarboxylated glycine; other site
362242009230	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070
362242009231	MPN+ (JAMM) motif; other site
362242009232	Zinc-binding site [ion binding]; other site
362242009233	nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252
362242009234	nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252
362242009235	cleavage site
362242009236	Domain of unknown function (DUF2017); Region: DUF2017; pfam09438
362242009237	ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033
362242009238	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
362242009239	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
362242009240	active site
362242009241	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
362242009242	DEAD/DEAH box helicase; Region: DEAD; pfam00270
362242009243	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
362242009244	putative Mg++ binding site [ion binding]; other site
362242009245	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
362242009246	This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299
362242009247	putative homodimer interface [polypeptide binding]; other site
362242009248	putative active site pocket [active]
362242009249	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
362242009250	Domain of unknown function (DUF3416); Region: DUF3416; pfam11896
362242009251	Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344
362242009252	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
362242009253	active site
362242009254	homodimer interface [polypeptide binding]; other site
362242009255	catalytic site [active]
362242009256	acceptor binding site [chemical binding]; other site
362242009257	glycogen branching enzyme; Provisional; Region: PRK05402
362242009258	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
362242009259	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
362242009260	active site
362242009261	catalytic site [active]
362242009262	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
362242009263	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
362242009264	ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
362242009265	putative acyltransferase; Provisional; Region: PRK05790
362242009266	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
362242009267	dimer interface [polypeptide binding]; other site
362242009268	active site
362242009269	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
362242009270	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
362242009271	dimer interface [polypeptide binding]; other site
362242009272	substrate binding site [chemical binding]; other site
362242009273	metal binding site [ion binding]; metal-binding site
362242009274	Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637
362242009275	hypothetical protein; Provisional; Region: PRK03298
362242009276	Transposase, Mutator family; Region: Transposase_mut; pfam00872
362242009277	MULE transposase domain; Region: MULE; pfam10551
362242009278	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242009279	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242009280	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242009281	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
362242009282	dimerization interface [polypeptide binding]; other site
362242009283	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
362242009284	cyclase homology domain; Region: CHD; cd07302
362242009285	nucleotidyl binding site; other site
362242009286	metal binding site [ion binding]; metal-binding site
362242009287	dimer interface [polypeptide binding]; other site
362242009288	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169
362242009289	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
362242009290	AlkA N-terminal domain; Region: AlkA_N; pfam06029
362242009291	3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122
362242009292	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
362242009293	minor groove reading motif; other site
362242009294	helix-hairpin-helix signature motif; other site
362242009295	substrate binding pocket [chemical binding]; other site
362242009296	active site
362242009297	methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901
362242009298	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
362242009299	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
362242009300	DNA binding site [nucleotide binding]
362242009301	active site
362242009302	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
362242009303	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
362242009304	hinge; other site
362242009305	active site
362242009306	cob(I)alamin adenosyltransferase [Coenzyme transport and    metabolism]; Region: COG2096
362242009307	Protein of unknown function (DUF2550); Region: DUF2550; pfam10739
362242009308	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
362242009309	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
362242009310	epsilon subunit interface [polypeptide binding]; other site
362242009311	gamma subunit interface [polypeptide binding]; other site
362242009312	LBP interface [polypeptide binding]; other site
362242009313	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
362242009314	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
362242009315	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
362242009316	alpha subunit interaction interface [polypeptide binding]; other site
362242009317	Walker A motif; other site
362242009318	ATP binding site [chemical binding]; other site
362242009319	Walker B motif; other site
362242009320	inhibitor binding site; inhibition site
362242009321	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
362242009322	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
362242009323	core domain interface [polypeptide binding]; other site
362242009324	delta subunit interface [polypeptide binding]; other site
362242009325	epsilon subunit interface [polypeptide binding]; other site
362242009326	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
362242009327	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
362242009328	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
362242009329	beta subunit interaction interface [polypeptide binding]; other site
362242009330	Walker A motif; other site
362242009331	ATP binding site [chemical binding]; other site
362242009332	Walker B motif; other site
362242009333	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
362242009334	F0F1 ATP synthase subunit delta; Provisional; Region: PRK13428
362242009335	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
362242009336	F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210
362242009337	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
362242009338	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
362242009339	F0F1 ATP synthase subunit C; Validated; Region: PRK05880
362242009340	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
362242009341	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
362242009342	ATP synthase I chain; Region: ATP_synt_I; cl09170
362242009343	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
362242009344	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
362242009345	Mg++ binding site [ion binding]; other site
362242009346	putative catalytic motif [active]
362242009347	substrate binding site [chemical binding]; other site
362242009348	tRNA threonylcarbamoyl adenosine modification protein, Sua5/YciO/YrdC/YwlC family; Region: TIGR00057
362242009349	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
362242009350	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
362242009351	S-adenosylmethionine binding site [chemical binding]; other site
362242009352	peptide chain release factor 1; Validated; Region: prfA; PRK00591
362242009353	This domain is found in peptide chain release factors; Region: PCRF; smart00937
362242009354	RF-1 domain; Region: RF-1; pfam00472
362242009355	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
362242009356	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
362242009357	transcription termination factor Rho; Provisional; Region: PRK12608
362242009358	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
362242009359	RNA binding site [nucleotide binding]; other site
362242009360	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
362242009361	multimer interface [polypeptide binding]; other site
362242009362	Walker A motif; other site
362242009363	ATP binding site [chemical binding]; other site
362242009364	Walker B motif; other site
362242009365	Homoserine kinase [Amino acid transport and metabolism]; Region: ThrB; COG0083
362242009366	threonine synthase; Reviewed; Region: PRK06721
362242009367	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
362242009368	homodimer interface [polypeptide binding]; other site
362242009369	pyridoxal 5'-phosphate binding site [chemical binding]; other site
362242009370	catalytic residue [active]
362242009371	homoserine dehydrogenase; Provisional; Region: PRK06349
362242009372	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
362242009373	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
362242009374	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
362242009375	diaminopimelate decarboxylase; Region: lysA; TIGR01048
362242009376	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
362242009377	active site
362242009378	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
362242009379	substrate binding site [chemical binding]; other site
362242009380	catalytic residues [active]
362242009381	dimer interface [polypeptide binding]; other site
362242009382	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
362242009383	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
362242009384	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
362242009385	active site
362242009386	HIGH motif; other site
362242009387	KMSK motif region; other site
362242009388	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
362242009389	tRNA binding surface [nucleotide binding]; other site
362242009390	anticodon binding site; other site
362242009392	PE family; Region: PE; pfam00934
362242009393	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
362242009394	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
362242009395	putative catalytic cysteine [active]
362242009396	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
362242009397	active site
362242009398	NAD binding site [chemical binding]; other site
362242009399	metal binding site [ion binding]; metal-binding site
362242009400	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
362242009401	YCII-related domain; Region: YCII; cl00999
362242009402	haloalkane dehalogenase; Provisional; Region: PRK03592
362242009403	putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976
362242009404	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939
362242009405	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
362242009406	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
362242009407	PE family; Region: PE; pfam00934
362242009408	Transcriptional regulator [Transcription]; Region: LysR; COG0583
362242009409	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
362242009410	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423
362242009411	putative dimerization interface [polypeptide binding]; other site
362242009412	Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006
362242009413	EamA-like transporter family; Region: EamA; pfam00892
362242009414	Protein of unknown function (DUF1211); Region: DUF1211; pfam06736
362242009415	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
362242009416	dimerization interface [polypeptide binding]; other site
362242009417	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
362242009418	cyclase homology domain; Region: CHD; cd07302
362242009419	nucleotidyl binding site; other site
362242009420	metal binding site [ion binding]; metal-binding site
362242009421	dimer interface [polypeptide binding]; other site
362242009422	Protein of unknown function (DUF732); Region: DUF732; pfam05305
362242009423	PE family; Region: PE; pfam00934
362242009424	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
362242009425	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242
362242009426	putative dimer interface [polypeptide binding]; other site
362242009427	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
362242009428	ligand binding site [chemical binding]; other site
362242009429	Zn binding site [ion binding]; other site
362242009430	ChaP, an enzyme involved in the biosynthesis of the antitumor agent chartreusin (cha); and similar proteins; Region: ChaP_like; cd08351
362242009431	metal binding site [ion binding]; metal-binding site
362242009432	Rrf2 family protein; Region: rrf2_super; TIGR00738
362242009433	Transcriptional regulator; Region: Rrf2; pfam02082
362242009434	bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506
362242009435	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
362242009436	CysD dimerization site [polypeptide binding]; other site
362242009437	G1 box; other site
362242009438	putative GEF interaction site [polypeptide binding]; other site
362242009439	GTP/Mg2+ binding site [chemical binding]; other site
362242009440	Switch I region; other site
362242009441	G2 box; other site
362242009442	G3 box; other site
362242009443	Switch II region; other site
362242009444	G4 box; other site
362242009445	G5 box; other site
362242009446	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
362242009447	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
362242009448	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
362242009449	ligand-binding site [chemical binding]; other site
362242009450	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
362242009451	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
362242009452	Active Sites [active]
362242009453	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
362242009454	CoenzymeA binding site [chemical binding]; other site
362242009455	subunit interaction site [polypeptide binding]; other site
362242009456	PHB binding site; other site
362242009457	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379
362242009458	active site clefts [active]
362242009459	zinc binding site [ion binding]; other site
362242009460	dimer interface [polypeptide binding]; other site
362242009461	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
362242009462	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
362242009463	dimer interface [polypeptide binding]; other site
362242009464	conserved gate region; other site
362242009465	putative PBP binding loops; other site
362242009466	ABC-ATPase subunit interface; other site
362242009467	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
362242009468	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
362242009469	dimer interface [polypeptide binding]; other site
362242009470	conserved gate region; other site
362242009471	putative PBP binding loops; other site
362242009472	ABC-ATPase subunit interface; other site
362242009473	glutathione transporter ATP-binding protein; Provisional; Region: PRK10261
362242009474	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
362242009475	Walker A/P-loop; other site
362242009476	ATP binding site [chemical binding]; other site
362242009477	Q-loop/lid; other site
362242009478	ABC transporter signature motif; other site
362242009479	Walker B; other site
362242009480	D-loop; other site
362242009481	H-loop/switch region; other site
362242009482	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
362242009483	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
362242009484	Walker A/P-loop; other site
362242009485	ATP binding site [chemical binding]; other site
362242009486	Q-loop/lid; other site
362242009487	ABC transporter signature motif; other site
362242009488	Walker B; other site
362242009489	D-loop; other site
362242009490	H-loop/switch region; other site
362242009491	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
362242009492	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
362242009493	The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501
362242009494	choline dehydrogenase; Validated; Region: PRK02106
362242009495	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
362242009496	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
362242009497	Walker A/P-loop; other site
362242009498	ATP binding site [chemical binding]; other site
362242009499	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
362242009500	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
362242009501	active site
362242009502	metal binding site [ion binding]; metal-binding site
362242009503	DNA binding site [nucleotide binding]
362242009504	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
362242009505	catalytic core [active]
362242009506	Protein of unknown function (DUF3558); Region: DUF3558; pfam12079
362242009507	Protein of unknown function (DUF3558); Region: DUF3558; pfam12079
362242009508	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
362242009509	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
362242009510	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
362242009511	Walker A/P-loop; other site
362242009512	ATP binding site [chemical binding]; other site
362242009513	Q-loop/lid; other site
362242009514	ABC transporter signature motif; other site
362242009515	Walker B; other site
362242009516	D-loop; other site
362242009517	H-loop/switch region; other site
362242009518	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
362242009519	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
362242009520	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
362242009521	Walker A/P-loop; other site
362242009522	ATP binding site [chemical binding]; other site
362242009523	Q-loop/lid; other site
362242009524	ABC transporter signature motif; other site
362242009525	Walker B; other site
362242009526	D-loop; other site
362242009527	H-loop/switch region; other site
362242009529	Protein of unknown function (DUF732); Region: DUF732; pfam05305
362242009530	Protein of unknown function (DUF732); Region: DUF732; pfam05305
362242009531	Protein of unknown function (DUF1396); Region: DUF1396; pfam07161
362242009532	Domain of unknown function (DUF4189); Region: DUF4189; pfam13827
362242009533	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
362242009534	putative active site [active]
362242009535	DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629
362242009536	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486
362242009537	DNA binding site [nucleotide binding]
362242009538	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
362242009539	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
362242009540	phosphopeptide binding site; other site
362242009541	Transcriptional regulator [Transcription]; Region: LysR; COG0583
362242009542	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
362242009543	The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434
362242009544	putative dimerization interface [polypeptide binding]; other site
362242009545	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
362242009546	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
362242009547	putative active site [active]
362242009548	putative catalytic site [active]
362242009549	Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427
362242009550	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
362242009551	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
362242009552	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
362242009553	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
362242009554	active site
362242009555	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial protein Rv2277c and similar proteins; Region: GDPD_Rv2277c_like; cd08580
362242009556	Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009
362242009557	putative active site [active]
362242009558	catalytic site [active]
362242009559	putative metal binding site [ion binding]; other site
362242009560	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
362242009561	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
362242009562	putative DNA binding site [nucleotide binding]; other site
362242009563	putative Zn2+ binding site [ion binding]; other site
362242009564	AsnC family; Region: AsnC_trans_reg; pfam01037
362242009565	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253
362242009566	dimer interface [polypeptide binding]; other site
362242009567	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
362242009568	metal binding site [ion binding]; metal-binding site
362242009569	Transposase, Mutator family; Region: Transposase_mut; pfam00872
362242009570	MULE transposase domain; Region: MULE; pfam10551
362242009571	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242009572	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242009573	Protein of unknown function (DUF2910); Region: DUF2910; pfam11139
362242009574	Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275
362242009575	The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_2; cd09320
362242009576	gating phenylalanine in ion channel; other site
362242009577	LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041
362242009578	Transcriptional regulator [Transcription]; Region: LytR; COG1316
362242009579	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
362242009580	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
362242009581	classical (c) SDRs; Region: SDR_c; cd05233
362242009582	NAD(P) binding site [chemical binding]; other site
362242009583	active site
362242009584	short chain dehydrogenase; Provisional; Region: PRK05875
362242009585	classical (c) SDRs; Region: SDR_c; cd05233
362242009586	NAD(P) binding site [chemical binding]; other site
362242009587	active site
362242009588	Phosphopantetheine attachment site; Region: PP-binding; cl09936
362242009589	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768
362242009590	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
362242009591	acyl-activating enzyme (AAE) consensus motif; other site
362242009592	active site
362242009593	7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156
362242009594	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
362242009595	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
362242009596	catalytic residue [active]
362242009597	Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424
362242009598	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
362242009599	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
362242009600	Walker A/P-loop; other site
362242009601	ATP binding site [chemical binding]; other site
362242009602	Q-loop/lid; other site
362242009603	ABC transporter signature motif; other site
362242009604	Walker B; other site
362242009605	D-loop; other site
362242009606	H-loop/switch region; other site
362242009607	Predicted transcriptional regulators [Transcription]; Region: COG1695
362242009608	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
362242009609	Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380
362242009610	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
362242009611	active site
362242009612	homotetramer interface [polypeptide binding]; other site
362242009613	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
362242009614	Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; cl09823
362242009615	mce related protein; Region: MCE; pfam02470
362242009616	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
362242009617	mce related protein; Region: MCE; pfam02470
362242009618	mce related protein; Region: MCE; pfam02470
362242009619	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
362242009620	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
362242009621	mce related protein; Region: MCE; pfam02470
362242009622	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
362242009623	mce related protein; Region: MCE; pfam02470
362242009624	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
362242009625	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
362242009626	mce related protein; Region: MCE; pfam02470
362242009627	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
362242009628	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
362242009629	Permease; Region: Permease; pfam02405
362242009630	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
362242009631	Permease; Region: Permease; pfam02405
362242009632	short chain dehydrogenase; Provisional; Region: PRK07791
362242009633	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
362242009634	NAD(P) binding site [chemical binding]; other site
362242009635	active site
362242009636	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
362242009637	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
362242009638	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
362242009639	Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152
362242009640	FAD binding site [chemical binding]; other site
362242009641	substrate binding site [chemical binding]; other site
362242009642	catalytic base [active]
362242009643	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
362242009644	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
362242009645	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
362242009646	active site
362242009647	acyl-CoA synthetase; Validated; Region: PRK07867
362242009648	Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940
362242009649	acyl-activating enzyme (AAE) consensus motif; other site
362242009650	putative AMP binding site [chemical binding]; other site
362242009651	putative active site [active]
362242009652	putative CoA binding site [chemical binding]; other site
362242009655	hypothetical protein; Validated; Region: PRK07586
362242009656	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
362242009657	PYR/PP interface [polypeptide binding]; other site
362242009658	dimer interface [polypeptide binding]; other site
362242009659	TPP binding site [chemical binding]; other site
362242009660	Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002
362242009661	TPP-binding site [chemical binding]; other site
362242009662	dimer interface [polypeptide binding]; other site
362242009663	Fructosamine kinase; Region: Fructosamin_kin; cl17579
362242009664	Phosphotransferase enzyme family; Region: APH; pfam01636
362242009665	acyl-CoA synthetase; Validated; Region: PRK07798
362242009666	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
362242009667	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924
362242009668	acyl-activating enzyme (AAE) consensus motif; other site
362242009669	acyl-activating enzyme (AAE) consensus motif; other site
362242009670	putative AMP binding site [chemical binding]; other site
362242009671	putative active site [active]
362242009672	putative CoA binding site [chemical binding]; other site
362242009673	enoyl-CoA hydratase; Provisional; Region: PRK07799
362242009674	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
362242009675	substrate binding site [chemical binding]; other site
362242009676	oxyanion hole (OAH) forming residues; other site
362242009677	trimer interface [polypeptide binding]; other site
362242009678	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
362242009679	Cytochrome P450; Region: p450; cl12078
362242009680	Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314
362242009681	probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559
362242009682	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
362242009683	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
362242009684	DUF35 OB-fold domain; Region: DUF35; pfam01796
362242009685	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
362242009686	DUF35 OB-fold domain; Region: DUF35; pfam01796
362242009687	lipid-transfer protein; Provisional; Region: PRK07937
362242009688	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
362242009689	active site
362242009690	acetyl-CoA acetyltransferase; Provisional; Region: PRK08313
362242009691	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
362242009692	active site
362242009693	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
362242009694	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
362242009695	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
362242009697	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
362242009698	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
362242009699	trimer interface [polypeptide binding]; other site
362242009700	putative metal binding site [ion binding]; other site
362242009701	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
362242009702	The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH).  The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531
362242009703	Sulfotransferase family; Region: Sulfotransfer_3; pfam13469
362242009704	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
362242009705	short chain dehydrogenase; Provisional; Region: PRK07890
362242009706	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
362242009707	NAD(P) binding site [chemical binding]; other site
362242009708	active site
362242009709	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
362242009710	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
362242009711	A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448
362242009712	4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195
362242009713	4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943
362242009714	active site
362242009715	catalytic residues [active]
362242009716	metal binding site [ion binding]; metal-binding site
362242009717	DmpG-like communication domain; Region: DmpG_comm; pfam07836
362242009718	acetaldehyde dehydrogenase; Validated; Region: PRK08300
362242009719	Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290
362242009720	2-keto-4-pentenoate hydratase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3971
362242009721	3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843
362242009722	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
362242009723	enoyl-CoA hydratase; Region: PLN02864
362242009724	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
362242009725	HDE_HSD  The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins.  Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448
362242009726	dimer interaction site [polypeptide binding]; other site
362242009727	substrate-binding tunnel; other site
362242009728	active site
362242009729	catalytic site [active]
362242009730	substrate binding site [chemical binding]; other site
362242009731	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
362242009732	lipid-transfer protein; Provisional; Region: PRK07855
362242009733	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
362242009734	active site
362242009735	SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  The alpha- and...; Region: SAV4209; cd03455
362242009736	putative active site [active]
362242009737	putative catalytic site [active]
362242009738	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
362242009739	active site
362242009740	catalytic site [active]
362242009741	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
362242009742	DUF35 OB-fold domain; Region: DUF35; pfam01796
362242009743	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
362242009744	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
362242009745	active site
362242009746	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
362242009747	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
362242009748	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
362242009749	active site
362242009750	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
362242009751	Cytochrome P450; Region: p450; cl12078
362242009752	acetyl-CoA acetyltransferase; Provisional; Region: PRK07850
362242009753	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
362242009754	dimer interface [polypeptide binding]; other site
362242009755	active site
362242009756	Domain of unknown function (DUF385); Region: DUF385; pfam04075
362242009757	short chain dehydrogenase; Provisional; Region: PRK07791
362242009758	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
362242009759	NAD(P) binding site [chemical binding]; other site
362242009760	active site
362242009761	short chain dehydrogenase; Provisional; Region: PRK07856
362242009762	classical (c) SDRs; Region: SDR_c; cd05233
362242009763	NAD(P) binding site [chemical binding]; other site
362242009764	active site
362242009765	enoyl-CoA hydratase; Provisional; Region: PRK06495
362242009766	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
362242009767	substrate binding site [chemical binding]; other site
362242009768	oxyanion hole (OAH) forming residues; other site
362242009769	trimer interface [polypeptide binding]; other site
362242009770	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
362242009771	Coenzyme A transferase; Region: CoA_trans; cl17247
362242009772	Nitronate monooxygenase; Region: NMO; pfam03060
362242009773	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
362242009774	FMN binding site [chemical binding]; other site
362242009775	substrate binding site [chemical binding]; other site
362242009776	putative catalytic residue [active]
362242009777	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
362242009778	Beta-carotene hydroxylase (CrtR), the carotenoid zeaxanthin biosynthetic enzyme catalyzes the addition of hydroxyl groups to the beta-ionone rings of beta-carotene to form zeaxanthin and is found in bacteria and red algae. Carotenoids are important...; Region: CrtR_beta-carotene-hydroxylase; cd03514
362242009779	putative di-iron ligands [ion binding]; other site
362242009780	phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160
362242009781	NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214
362242009782	FAD binding pocket [chemical binding]; other site
362242009783	FAD binding motif [chemical binding]; other site
362242009784	phosphate binding motif [ion binding]; other site
362242009785	beta-alpha-beta structure motif; other site
362242009786	NAD(p) ribose binding residues [chemical binding]; other site
362242009787	NAD binding pocket [chemical binding]; other site
362242009788	NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site
362242009789	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
362242009790	catalytic loop [active]
362242009791	iron binding site [ion binding]; other site
362242009792	acetyl-CoA acetyltransferase; Provisional; Region: PRK07801
362242009793	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
362242009794	dimer interface [polypeptide binding]; other site
362242009795	active site
362242009796	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
362242009797	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
362242009798	YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359
362242009799	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242009800	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242009801	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242009802	short chain dehydrogenase; Provisional; Region: PRK07831
362242009803	classical (c) SDRs; Region: SDR_c; cd05233
362242009804	NAD(P) binding site [chemical binding]; other site
362242009805	active site
362242009806	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
362242009807	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
362242009808	active site
362242009809	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656
362242009810	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
362242009811	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
362242009812	acyl-activating enzyme (AAE) consensus motif; other site
362242009813	acyl-activating enzyme (AAE) consensus motif; other site
362242009814	putative AMP binding site [chemical binding]; other site
362242009815	putative active site [active]
362242009816	putative CoA binding site [chemical binding]; other site
362242009817	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
362242009818	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
362242009819	active site
362242009820	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
362242009821	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
362242009822	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
362242009823	active site
362242009824	pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203
362242009825	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
362242009826	aspartate aminotransferase; Provisional; Region: PRK05764
362242009827	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
362242009828	pyridoxal 5'-phosphate binding site [chemical binding]; other site
362242009829	homodimer interface [polypeptide binding]; other site
362242009830	catalytic residue [active]
362242009831	Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162
362242009832	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
362242009833	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
362242009834	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
362242009835	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
362242009836	Peptidase family M48; Region: Peptidase_M48; cl12018
362242009837	Penicillinase repressor; Region: Pencillinase_R; pfam03965
362242009838	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
362242009839	2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213
362242009840	N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252
362242009841	C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237
362242009842	active site
362242009843	Fe binding site [ion binding]; other site
362242009844	2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343
362242009845	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
362242009846	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
362242009847	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
362242009848	Naphthocyclinone hydroxylase; Region: NcnH; cd01159
362242009849	Flavin binding site [chemical binding]; other site
362242009850	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
362242009851	NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214
362242009852	FAD binding pocket [chemical binding]; other site
362242009853	FAD binding motif [chemical binding]; other site
362242009854	phosphate binding motif [ion binding]; other site
362242009855	beta-alpha-beta structure motif; other site
362242009856	NAD(p) ribose binding residues [chemical binding]; other site
362242009857	NAD binding pocket [chemical binding]; other site
362242009858	NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site
362242009859	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
362242009860	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
362242009861	catalytic loop [active]
362242009862	iron binding site [ion binding]; other site
362242009863	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
362242009864	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
362242009865	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
362242009866	active site
362242009867	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
362242009868	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
362242009869	active site
362242009870	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
362242009871	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
362242009872	Transcriptional regulators [Transcription]; Region: PurR; COG1609
362242009873	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
362242009874	DNA binding site [nucleotide binding]
362242009875	domain linker motif; other site
362242009876	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279
362242009877	putative dimerization interface [polypeptide binding]; other site
362242009878	putative ligand binding site [chemical binding]; other site
362242009879	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
362242009880	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
362242009881	intersubunit interface [polypeptide binding]; other site
362242009882	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
362242009883	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
362242009884	Walker A/P-loop; other site
362242009885	ATP binding site [chemical binding]; other site
362242009886	Q-loop/lid; other site
362242009887	ABC transporter signature motif; other site
362242009888	Walker B; other site
362242009889	D-loop; other site
362242009890	H-loop/switch region; other site
362242009891	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
362242009892	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
362242009893	PknH-like extracellular domain; Region: PknH_C; pfam14032
362242009894	PknH-like extracellular domain; Region: PknH_C; pfam14032
362242009895	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
362242009896	putative active site [active]
362242009897	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
362242009898	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
362242009899	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
362242009900	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
362242009901	transmembrane helices; other site
362242009902	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
362242009903	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
362242009904	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
362242009905	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
362242009906	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
362242009907	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
362242009908	active site
362242009909	HIGH motif; other site
362242009910	nucleotide binding site [chemical binding]; other site
362242009911	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
362242009912	KMSKS motif; other site
362242009913	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
362242009914	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
362242009915	homotrimer interaction site [polypeptide binding]; other site
362242009916	zinc binding site [ion binding]; other site
362242009917	CDP-binding sites; other site
362242009918	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
362242009919	substrate binding site; other site
362242009920	dimer interface; other site
362242009921	Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329
362242009922	DNA integrity scanning protein DisA; Provisional; Region: PRK13482
362242009923	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
362242009924	DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635
362242009925	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378
362242009926	active site clefts [active]
362242009927	zinc binding site [ion binding]; other site
362242009928	dimer interface [polypeptide binding]; other site
362242009929	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
362242009930	endonuclease III; Region: ENDO3c; smart00478
362242009931	minor groove reading motif; other site
362242009932	helix-hairpin-helix signature motif; other site
362242009933	substrate binding pocket [chemical binding]; other site
362242009934	active site
362242009935	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
362242009936	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
362242009937	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
362242009938	catalytic site [active]
362242009939	Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367
362242009940	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
362242009941	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
362242009942	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
362242009943	Ligand binding site; other site
362242009944	Putative Catalytic site; other site
362242009945	DXD motif; other site
362242009946	methyl viologen resistance protein SmvA; Provisional; Region: PRK14995
362242009947	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
362242009948	putative substrate translocation pore; other site
362242009949	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
362242009950	catalytic core [active]
362242009951	Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266
362242009954	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242009955	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242009956	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242009957	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
362242009958	Clp amino terminal domain; Region: Clp_N; pfam02861
362242009959	Clp amino terminal domain; Region: Clp_N; pfam02861
362242009960	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
362242009961	Walker A motif; other site
362242009962	ATP binding site [chemical binding]; other site
362242009963	Walker B motif; other site
362242009964	arginine finger; other site
362242009965	UvrB/uvrC motif; Region: UVR; pfam02151
362242009966	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
362242009967	Walker A motif; other site
362242009968	ATP binding site [chemical binding]; other site
362242009969	Walker B motif; other site
362242009970	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
362242009971	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242009972	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242009973	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242009974	Lsr2; Region: Lsr2; pfam11774
362242009975	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
362242009976	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
362242009977	dimer interface [polypeptide binding]; other site
362242009978	putative anticodon binding site; other site
362242009979	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
362242009980	motif 1; other site
362242009981	dimer interface [polypeptide binding]; other site
362242009982	active site
362242009983	motif 2; other site
362242009984	motif 3; other site
362242009985	pantothenate kinase; Reviewed; Region: PRK13318
362242009986	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
362242009987	tetramerization interface [polypeptide binding]; other site
362242009988	active site
362242009989	Pantoate-beta-alanine ligase; Region: PanC; cd00560
362242009990	pantoate--beta-alanine ligase; Region: panC; TIGR00018
362242009991	active site
362242009992	ATP-binding site [chemical binding]; other site
362242009993	pantoate-binding site; other site
362242009994	HXXH motif; other site
362242009995	Uncharacterized conserved protein [Function unknown]; Region: COG5495
362242009996	Rossmann-like domain; Region: Rossmann-like; pfam10727
362242009997	Domain of unknown function (DUF2520); Region: DUF2520; pfam10728
362242009998	Protein of unknown function (DUF3180); Region: DUF3180; pfam11377
362242009999	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
362242010000	catalytic center binding site [active]
362242010001	ATP binding site [chemical binding]; other site
362242010002	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
362242010003	homooctamer interface [polypeptide binding]; other site
362242010004	active site
362242010005	dihydropteroate synthase; Region: DHPS; TIGR01496
362242010006	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
362242010007	substrate binding pocket [chemical binding]; other site
362242010008	dimer interface [polypeptide binding]; other site
362242010009	inhibitor binding site; inhibition site
362242010010	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
362242010011	GTP cyclohydrolase I; Provisional; Region: PLN03044
362242010012	homodecamer interface [polypeptide binding]; other site
362242010013	active site
362242010014	putative catalytic site residues [active]
362242010015	zinc binding site [ion binding]; other site
362242010016	GTP-CH-I/GFRP interaction surface; other site
362242010017	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
362242010018	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
362242010019	Walker A motif; other site
362242010020	ATP binding site [chemical binding]; other site
362242010021	Walker B motif; other site
362242010022	arginine finger; other site
362242010023	Peptidase family M41; Region: Peptidase_M41; pfam01434
362242010024	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
362242010025	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
362242010026	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
362242010027	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
362242010028	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
362242010029	PPE family; Region: PPE; pfam00823
362242010030	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
362242010031	PE family; Region: PE; pfam00934
362242010032	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242010033	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242010034	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242010035	Uncharacterized conserved protein [Function unknown]; Region: COG2968
362242010036	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
362242010037	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
362242010038	active site
362242010039	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
362242010040	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
362242010041	Ligand Binding Site [chemical binding]; other site
362242010042	uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883
362242010043	putative hydrolase; Region: TIGR03624
362242010044	D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027
362242010045	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
362242010046	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
362242010047	dimer interface [polypeptide binding]; other site
362242010048	substrate binding site [chemical binding]; other site
362242010049	metal binding sites [ion binding]; metal-binding site
362242010050	hypothetical protein; Provisional; Region: PRK14013
362242010051	Transposase, Mutator family; Region: Transposase_mut; pfam00872
362242010052	MULE transposase domain; Region: MULE; pfam10551
362242010053	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
362242010054	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
362242010055	Ligand binding site; other site
362242010056	Putative Catalytic site; other site
362242010057	DXD motif; other site
362242010058	Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034
362242010059	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
362242010060	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
362242010061	NAD(P) binding site [chemical binding]; other site
362242010062	active site
362242010064	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
362242010065	Transposase, Mutator family; Region: Transposase_mut; pfam00872
362242010066	MULE transposase domain; Region: MULE; pfam10551
362242010068	VbhA antitoxin and related proteins; Region: VbhA_like; cd11586
362242010069	FIC domain binding interface [polypeptide binding]; other site
362242010070	DNA polymerase III subunit delta'; Validated; Region: PRK07940
362242010071	DNA polymerase III subunit delta'; Validated; Region: PRK08485
362242010072	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
362242010073	dimerization interface [polypeptide binding]; other site
362242010074	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
362242010075	cyclase homology domain; Region: CHD; cd07302
362242010076	nucleotidyl binding site; other site
362242010077	metal binding site [ion binding]; metal-binding site
362242010078	dimer interface [polypeptide binding]; other site
362242010079	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
362242010080	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
362242010081	active site
362242010082	interdomain interaction site; other site
362242010083	putative metal-binding site [ion binding]; other site
362242010084	nucleotide binding site [chemical binding]; other site
362242010085	Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436
362242010086	domain I; other site
362242010087	phosphate binding site [ion binding]; other site
362242010088	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
362242010089	domain II; other site
362242010090	domain III; other site
362242010091	nucleotide binding site [chemical binding]; other site
362242010092	DNA binding groove [nucleotide binding]
362242010093	catalytic site [active]
362242010094	domain IV; other site
362242010095	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
362242010096	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
362242010097	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
362242010098	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
362242010099	DNA-binding site [nucleotide binding]; DNA binding site
362242010100	RNA-binding motif; other site
362242010101	Protein of unknown function (DUF4244); Region: DUF4244; pfam14029
362242010102	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
362242010103	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
362242010104	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
362242010105	Walker A motif; other site
362242010106	hexamer interface [polypeptide binding]; other site
362242010107	ATP binding site [chemical binding]; other site
362242010108	Walker B motif; other site
362242010109	helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815
362242010110	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
362242010111	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
362242010112	motif II; other site
362242010113	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
362242010114	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
362242010115	Walker A/P-loop; other site
362242010116	ATP binding site [chemical binding]; other site
362242010117	Q-loop/lid; other site
362242010118	ABC transporter signature motif; other site
362242010119	Walker B; other site
362242010120	D-loop; other site
362242010121	H-loop/switch region; other site
362242010122	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
362242010123	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
362242010124	Walker A/P-loop; other site
362242010125	ATP binding site [chemical binding]; other site
362242010126	Q-loop/lid; other site
362242010127	ABC transporter signature motif; other site
362242010128	Walker B; other site
362242010129	D-loop; other site
362242010130	H-loop/switch region; other site
362242010131	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
362242010132	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
362242010133	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
362242010134	dimer interface [polypeptide binding]; other site
362242010135	conserved gate region; other site
362242010136	putative PBP binding loops; other site
362242010137	ABC-ATPase subunit interface; other site
362242010138	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
362242010139	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
362242010140	dimer interface [polypeptide binding]; other site
362242010141	conserved gate region; other site
362242010142	ABC-ATPase subunit interface; other site
362242010143	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
362242010144	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
362242010145	acetyl-CoA synthetase; Provisional; Region: PRK00174
362242010146	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
362242010147	active site
362242010148	CoA binding site [chemical binding]; other site
362242010149	acyl-activating enzyme (AAE) consensus motif; other site
362242010150	AMP binding site [chemical binding]; other site
362242010151	acetate binding site [chemical binding]; other site
362242010152	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
362242010153	Protein of unknown function (DUF1469); Region: DUF1469; pfam07332
362242010154	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
362242010155	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
362242010156	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
362242010157	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
362242010158	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
362242010159	catalytic residues [active]
362242010160	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
362242010161	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
362242010162	minor groove reading motif; other site
362242010163	helix-hairpin-helix signature motif; other site
362242010164	substrate binding pocket [chemical binding]; other site
362242010165	active site
362242010166	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
362242010167	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
362242010168	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
362242010169	ligand binding site [chemical binding]; other site
362242010170	flexible hinge region; other site
362242010171	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
362242010172	putative switch regulator; other site
362242010173	non-specific DNA interactions [nucleotide binding]; other site
362242010174	DNA binding site [nucleotide binding]
362242010175	sequence specific DNA binding site [nucleotide binding]; other site
362242010176	putative cAMP binding site [chemical binding]; other site
362242010177	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
362242010178	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
362242010179	homotrimer interaction site [polypeptide binding]; other site
362242010180	putative active site [active]
362242010181	Domain of unknown function (DUF4177); Region: DUF4177; pfam13783
362242010182	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
362242010183	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
362242010184	P loop; other site
362242010185	Nucleotide binding site [chemical binding]; other site
362242010186	DTAP/Switch II; other site
362242010187	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
362242010188	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
362242010189	DTAP/Switch II; other site
362242010190	Switch I; other site
362242010191	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
362242010192	Transcription factor WhiB; Region: Whib; pfam02467
362242010193	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
362242010194	Transglycosylase; Region: Transgly; pfam00912
362242010195	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
362242010196	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
362242010197	phosphodiesterase YaeI; Provisional; Region: PRK11340
362242010198	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
362242010199	putative active site [active]
362242010200	putative metal binding site [ion binding]; other site
362242010201	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
362242010202	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
362242010203	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
362242010204	catalytic residue [active]
362242010205	Domain of unknown function (DUF4193); Region: DUF4193; pfam13834
362242010206	Polysulphide reductase, NrfD; Region: NrfD; pfam03916
362242010207	Yqey-like protein; Region: YqeY; pfam09424
362242010208	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
362242010209	MoxR-like ATPases [General function prediction only]; Region: COG0714
362242010210	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
362242010211	Walker A motif; other site
362242010212	ATP binding site [chemical binding]; other site
362242010213	Walker B motif; other site
362242010214	arginine finger; other site
362242010215	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
362242010216	Protein of unknown function DUF58; Region: DUF58; pfam01882
362242010217	Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300
362242010218	Predicted membrane protein/domain [Function unknown]; Region: COG1714
362242010219	Predicted transcriptional regulators [Transcription]; Region: COG1695
362242010220	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
362242010223	glycerol kinase; Provisional; Region: glpK; PRK00047
362242010224	Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789
362242010225	N- and C-terminal domain interface [polypeptide binding]; other site
362242010226	active site
362242010227	MgATP binding site [chemical binding]; other site
362242010228	catalytic site [active]
362242010229	metal binding site [ion binding]; metal-binding site
362242010230	putative homotetramer interface [polypeptide binding]; other site
362242010231	glycerol binding site [chemical binding]; other site
362242010232	homodimer interface [polypeptide binding]; other site
362242010233	ergothioneine biosynthesis PLP-dependent enzyme EgtE; Region: egtE_PLP_lyase; TIGR04343
362242010234	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
362242010235	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
362242010236	catalytic residue [active]
362242010237	Uncharacterized conserved protein [Function unknown]; Region: COG4301
362242010238	Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017
362242010239	ergothioneine biosynthesis protein EgtC; Region: TIGR03442
362242010240	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
362242010241	putative active site [active]
362242010242	putative dimer interface [polypeptide binding]; other site
362242010243	ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440
362242010244	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
362242010245	PknH-like extracellular domain; Region: PknH_C; pfam14032
362242010246	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
362242010247	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
362242010248	tetramer interface [polypeptide binding]; other site
362242010249	heme binding pocket [chemical binding]; other site
362242010250	NADPH binding site [chemical binding]; other site
362242010253	Domain of unknown function (DUF4185); Region: DUF4185; pfam13810
362242010254	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
362242010255	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
362242010256	aspartate kinase; Reviewed; Region: PRK06635
362242010257	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
362242010258	putative nucleotide binding site [chemical binding]; other site
362242010259	putative catalytic residues [active]
362242010260	putative Mg ion binding site [ion binding]; other site
362242010261	putative aspartate binding site [chemical binding]; other site
362242010262	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
362242010263	putative allosteric regulatory site; other site
362242010264	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
362242010265	putative allosteric regulatory residue; other site
362242010266	2-isopropylmalate synthase; Validated; Region: PRK03739
362242010267	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
362242010268	active site
362242010269	catalytic residues [active]
362242010270	metal binding site [ion binding]; metal-binding site
362242010271	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
362242010272	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226
362242010273	DNA polymerase III subunit epsilon; Provisional; Region: PRK06063
362242010274	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
362242010275	active site
362242010276	catalytic site [active]
362242010277	substrate binding site [chemical binding]; other site
362242010278	UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769
362242010279	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
362242010280	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
362242010281	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
362242010282	catalytic triad [active]
362242010283	recombination protein RecR; Reviewed; Region: recR; PRK00076
362242010284	RecR protein; Region: RecR; pfam02132
362242010285	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
362242010286	putative active site [active]
362242010287	putative metal-binding site [ion binding]; other site
362242010288	tetramer interface [polypeptide binding]; other site
362242010289	hypothetical protein; Validated; Region: PRK00153
362242010290	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
362242010291	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
362242010292	active site
362242010293	metal binding site [ion binding]; metal-binding site
362242010294	Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604
362242010295	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
362242010296	FAD binding domain; Region: FAD_binding_4; pfam01565
362242010297	Conserved hypothetical protein (DUF2461); Region: DUF2461; cl02374
362242010298	RDD family; Region: RDD; cl00746
362242010299	DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
362242010300	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
362242010301	Walker A motif; other site
362242010302	ATP binding site [chemical binding]; other site
362242010303	Walker B motif; other site
362242010304	arginine finger; other site
362242010305	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
362242010306	Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897
362242010307	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
362242010308	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
362242010309	catalytic residue [active]
362242010310	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
362242010311	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
362242010312	substrate binding site [chemical binding]; other site
362242010313	oxyanion hole (OAH) forming residues; other site
362242010314	trimer interface [polypeptide binding]; other site
362242010315	Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481
362242010316	Cutinase; Region: Cutinase; pfam01083
362242010317	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
362242010318	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
362242010319	NAD(P) binding site [chemical binding]; other site
362242010320	active site
362242010321	PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666
362242010322	Uncharacterized conserved protein [Function unknown]; Region: COG2128
362242010323	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
362242010324	PE family; Region: PE; pfam00934
362242010325	LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865
362242010326	nucleotide binding site [chemical binding]; other site
362242010327	ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224
362242010328	Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905
362242010329	active site
362242010330	DNA binding site [nucleotide binding]
362242010331	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970
362242010332	DNA binding site [nucleotide binding]
362242010333	Uncharacterized protein conserved in bacteria (DUF2330); Region: DUF2330; pfam10092
362242010334	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
362242010335	nudix motif; other site
362242010336	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
362242010337	Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263
362242010338	putative NAD(P) binding site [chemical binding]; other site
362242010339	active site
362242010340	putative substrate binding site [chemical binding]; other site
362242010341	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
362242010342	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
362242010343	putative acyl-acceptor binding pocket; other site
362242010344	Adenosine specific kinase; Region: Adenosine_kin; pfam04008
362242010345	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
362242010346	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
362242010347	acyl-activating enzyme (AAE) consensus motif; other site
362242010348	putative AMP binding site [chemical binding]; other site
362242010349	putative active site [active]
362242010350	putative CoA binding site [chemical binding]; other site
362242010351	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
362242010352	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
362242010353	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
362242010354	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
362242010355	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
362242010356	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
362242010357	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
362242010358	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
362242010359	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
362242010360	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
362242010361	classical (c) SDRs; Region: SDR_c; cd05233
362242010362	NAD(P) binding site [chemical binding]; other site
362242010363	active site
362242010364	Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169
362242010365	dimerization interface [polypeptide binding]; other site
362242010366	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
362242010367	NAD binding site [chemical binding]; other site
362242010368	ligand binding site [chemical binding]; other site
362242010369	catalytic site [active]
362242010370	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
362242010371	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
362242010372	acyl-activating enzyme (AAE) consensus motif; other site
362242010373	AMP binding site [chemical binding]; other site
362242010374	active site
362242010375	CoA binding site [chemical binding]; other site
362242010376	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
362242010377	non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353
362242010378	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
362242010379	putative trimer interface [polypeptide binding]; other site
362242010380	putative CoA binding site [chemical binding]; other site
362242010381	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
362242010382	putative trimer interface [polypeptide binding]; other site
362242010383	putative CoA binding site [chemical binding]; other site
362242010384	Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603
362242010385	Zn binding site [ion binding]; other site
362242010386	Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996
362242010387	PE family; Region: PE; pfam00934
362242010388	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
362242010389	classical (c) SDRs; Region: SDR_c; cd05233
362242010390	NAD(P) binding site [chemical binding]; other site
362242010391	active site
362242010392	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
362242010393	TM2 domain; Region: TM2; pfam05154
362242010394	Putative heavy-metal-binding; Region: YbjQ_1; cl00426
362242010395	PE family; Region: PE; pfam00934
362242010398	Transposase, Mutator family; Region: Transposase_mut; pfam00872
362242010399	MULE transposase domain; Region: MULE; pfam10551
362242010400	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
362242010401	nucleoside/Zn binding site; other site
362242010402	dimer interface [polypeptide binding]; other site
362242010403	catalytic motif [active]
362242010404	putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941
362242010405	Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287
362242010406	prephenate dehydrogenase; Validated; Region: PRK08507
362242010407	Putative glycolipid-binding; Region: Glycolipid_bind; cl01425
362242010408	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
362242010409	ABC-ATPase subunit interface; other site
362242010410	ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174
362242010411	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
362242010412	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
362242010413	Uncharacterized integral membrane protein [Function unknown]; Region: COG5416
362242010414	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
362242010415	catalytic core [active]
362242010416	PE family; Region: PE; pfam00934
362242010420	Phosphotransferase enzyme family; Region: APH; pfam01636
362242010421	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
362242010422	putative active site [active]
362242010423	putative substrate binding site [chemical binding]; other site
362242010424	ATP binding site [chemical binding]; other site
362242010425	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
362242010426	classical (c) SDRs; Region: SDR_c; cd05233
362242010427	NAD(P) binding site [chemical binding]; other site
362242010428	active site
362242010429	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
362242010430	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
362242010431	active site
362242010432	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
362242010433	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
362242010434	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
362242010435	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
362242010436	NAD(P) binding site [chemical binding]; other site
362242010437	Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015
362242010438	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
362242010439	Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481
362242010440	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
362242010441	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
362242010442	active site
362242010443	phosphorylation site [posttranslational modification]
362242010444	intermolecular recognition site; other site
362242010445	dimerization interface [polypeptide binding]; other site
362242010446	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
362242010447	DNA binding site [nucleotide binding]
362242010448	Transposase, Mutator family; Region: Transposase_mut; pfam00872
362242010449	MULE transposase domain; Region: MULE; pfam10551
362242010450	Transposase, Mutator family; Region: Transposase_mut; pfam00872
362242010451	MULE transposase domain; Region: MULE; pfam10551
362242010452	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242010453	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242010454	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242010455	PE family; Region: PE; pfam00934
362242010458	PE family; Region: PE; pfam00934
362242010459	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242010460	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242010461	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242010462	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
362242010463	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
362242010464	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
362242010465	Phosphotransferase enzyme family; Region: APH; pfam01636
362242010466	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
362242010467	putative active site [active]
362242010468	putative substrate binding site [chemical binding]; other site
362242010469	ATP binding site [chemical binding]; other site
362242010470	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
362242010471	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
362242010472	pyridoxal 5'-phosphate binding site [chemical binding]; other site
362242010473	homodimer interface [polypeptide binding]; other site
362242010474	catalytic residue [active]
362242010475	GXWXG protein; Region: GXWXG; pfam14231
362242010476	Domain of unknown function (DUF4334); Region: DUF4334; pfam14232
362242010477	TIGR03086 family protein; Region: TIGR03086
362242010478	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
362242010479	enoyl-CoA hydratase; Provisional; Region: PRK06142
362242010480	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
362242010481	substrate binding site [chemical binding]; other site
362242010482	oxyanion hole (OAH) forming residues; other site
362242010483	trimer interface [polypeptide binding]; other site
362242010484	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
362242010485	Beta-lactamase; Region: Beta-lactamase; pfam00144
362242010486	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242010487	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242010488	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242010489	hypothetical protein; Provisional; Region: PRK07857
362242010490	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242010491	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242010492	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242010493	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
362242010494	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
362242010495	active site
362242010496	dimer interface [polypeptide binding]; other site
362242010497	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
362242010498	dimer interface [polypeptide binding]; other site
362242010499	active site
362242010500	short chain dehydrogenase; Provisional; Region: PRK08251
362242010501	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
362242010502	NAD(P) binding site [chemical binding]; other site
362242010503	active site
362242010504	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
362242010505	Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei  (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973
362242010506	putative DNA binding site [nucleotide binding]; other site
362242010507	catalytic residue [active]
362242010508	putative H2TH interface [polypeptide binding]; other site
362242010509	putative catalytic residues [active]
362242010510	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
362242010511	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
362242010512	PE family; Region: PE; pfam00934
362242010513	Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643
362242010514	active site
362242010515	SAM binding site [chemical binding]; other site
362242010516	homodimer interface [polypeptide binding]; other site
362242010517	P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583
362242010518	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
362242010519	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
362242010520	anti sigma factor interaction site; other site
362242010521	regulatory phosphorylation site [posttranslational modification]; other site
362242010522	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
362242010523	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
362242010524	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
362242010525	substrate binding site [chemical binding]; other site
362242010526	oxyanion hole (OAH) forming residues; other site
362242010527	trimer interface [polypeptide binding]; other site
362242010528	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
362242010529	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
362242010530	PE family; Region: PE; pfam00934
362242010531	ATP-dependent DNA ligase; Reviewed; Region: PRK09632
362242010532	MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863
362242010533	nucleotide binding site [chemical binding]; other site
362242010534	DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777
362242010535	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
362242010536	active site
362242010537	DNA binding site [nucleotide binding]
362242010538	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
362242010539	DNA binding site [nucleotide binding]
362242010540	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
362242010541	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
362242010542	putative substrate binding site [chemical binding]; other site
362242010543	putative ATP binding site [chemical binding]; other site
362242010544	Ku protein, prokaryotic; Region: Ku_bact; TIGR02772
362242010545	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
362242010546	putative DNA binding site [nucleotide binding]; other site
362242010547	putative homodimer interface [polypeptide binding]; other site
362242010548	PBP superfamily domain; Region: PBP_like_2; cl17296
362242010549	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
362242010550	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
362242010551	dimer interface [polypeptide binding]; other site
362242010552	conserved gate region; other site
362242010553	putative PBP binding loops; other site
362242010554	ABC-ATPase subunit interface; other site
362242010555	phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138
362242010556	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
362242010557	dimer interface [polypeptide binding]; other site
362242010558	conserved gate region; other site
362242010559	putative PBP binding loops; other site
362242010560	ABC-ATPase subunit interface; other site
362242010561	PBP superfamily domain; Region: PBP_like_2; cl17296
362242010562	short chain dehydrogenase; Provisional; Region: PRK07814
362242010563	classical (c) SDRs; Region: SDR_c; cd05233
362242010564	NAD(P) binding site [chemical binding]; other site
362242010565	active site
362242010566	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
362242010567	manganese transport protein MntH; Reviewed; Region: PRK00701
362242010568	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
362242010569	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
362242010570	putative active site pocket [active]
362242010571	dimerization interface [polypeptide binding]; other site
362242010572	putative catalytic residue [active]
362242010573	Protein of unknown function (DUF867); Region: DUF867; cl01713
362242010574	probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621
362242010575	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
362242010576	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
362242010581	Transposase IS200 like; Region: Y1_Tnp; pfam01797
362242010582	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
362242010583	PPE family; Region: PPE; pfam00823
362242010584	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
362242010585	S-adenosylmethionine binding site [chemical binding]; other site
362242010586	Cupin superfamily (DUF985); Region: Cupin_5; cl01418
362242010587	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
362242010588	PE family; Region: PE; pfam00934
362242010589	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
362242010590	PPE family; Region: PPE; pfam00823
362242010591	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
362242010592	Transposase, Mutator family; Region: Transposase_mut; pfam00872
362242010593	MULE transposase domain; Region: MULE; pfam10551
362242010594	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
362242010595	cyclase homology domain; Region: CHD; cd07302
362242010596	nucleotidyl binding site; other site
362242010597	metal binding site [ion binding]; metal-binding site
362242010598	dimer interface [polypeptide binding]; other site
362242010599	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
362242010600	Catalytic domain of Protein Kinases; Region: PKc; cd00180
362242010601	active site
362242010602	ATP binding site [chemical binding]; other site
362242010603	substrate binding site [chemical binding]; other site
362242010604	activation loop (A-loop); other site
362242010605	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242010606	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242010607	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242010608	Transposase, Mutator family; Region: Transposase_mut; pfam00872
362242010609	MULE transposase domain; Region: MULE; pfam10551
362242010610	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242010611	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242010612	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242010613	amidase; Provisional; Region: PRK12470
362242010614	Amidase; Region: Amidase; cl11426
362242010615	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
362242010616	HIT family signature motif; other site
362242010617	catalytic residue [active]
362242010618	Domain of unknown function (DUF385); Region: DUF385; pfam04075
362242010619	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
362242010620	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
362242010621	hypothetical protein; Validated; Region: PRK05868
362242010622	hypothetical protein; Provisional; Region: PRK07236
362242010623	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
362242010624	Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031
362242010625	Fe-S cluster binding site [ion binding]; other site
362242010626	DNA binding site [nucleotide binding]
362242010627	active site
362242010628	FAD binding domain; Region: FAD_binding_4; pfam01565
362242010629	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
362242010630	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
362242010631	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
362242010632	PE family; Region: PE; pfam00934
362242010633	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
362242010634	PPE family; Region: PPE; pfam00823
362242010635	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
362242010636	LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041
362242010637	Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251
362242010638	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
362242010639	RNase_H superfamily; Region: RNase_H_2; pfam13482
362242010640	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
362242010641	Part of AAA domain; Region: AAA_19; pfam13245
362242010642	AAA domain; Region: AAA_12; pfam13087
362242010643	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242010644	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
362242010645	alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270
362242010646	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
362242010647	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
362242010648	TPP-binding site [chemical binding]; other site
362242010649	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
362242010650	dimer interface [polypeptide binding]; other site
362242010651	PYR/PP interface [polypeptide binding]; other site
362242010652	TPP binding site [chemical binding]; other site
362242010653	classical (c) SDRs; Region: SDR_c; cd05233
362242010654	short chain dehydrogenase; Provisional; Region: PRK08267
362242010655	NAD(P) binding site [chemical binding]; other site
362242010656	active site
362242010657	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
362242010658	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
362242010659	Malic enzyme, N-terminal domain; Region: malic; pfam00390
362242010660	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
362242010661	putative NAD(P) binding site [chemical binding]; other site
362242010662	malate dehydrogenase; Provisional; Region: PRK05442
362242010663	Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338
362242010664	NAD(P) binding site [chemical binding]; other site
362242010665	dimer interface [polypeptide binding]; other site
362242010666	malate binding site [chemical binding]; other site
362242010667	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242010668	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242010669	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242010670	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
362242010671	alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565
362242010672	active site
362242010673	dimer interface [polypeptide binding]; other site
362242010674	non-prolyl cis peptide bond; other site
362242010675	insertion regions; other site
362242010676	gamma-aminobutyrate permease; Region: GABAperm; TIGR01773
362242010677	Suppressor of fused protein (SUFU); Region: SUFU; pfam05076
362242010678	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
362242010679	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
362242010680	dimer interface [polypeptide binding]; other site
362242010681	conserved gate region; other site
362242010682	ABC-ATPase subunit interface; other site
362242010683	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
362242010684	dimer interface [polypeptide binding]; other site
362242010685	conserved gate region; other site
362242010686	putative PBP binding loops; other site
362242010687	ABC-ATPase subunit interface; other site
362242010688	Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951
362242010689	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
362242010690	N-acetyl-D-glucosamine binding site [chemical binding]; other site
362242010691	catalytic residue [active]
362242010692	Domain of unknown function DUF59; Region: DUF59; cl00941
362242010693	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
362242010694	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
362242010695	sec-independent translocase; Provisional; Region: PRK03100
362242010696	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
362242010697	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
362242010698	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
362242010699	protein binding site [polypeptide binding]; other site
362242010700	RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647
362242010701	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
362242010702	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
362242010703	DNA binding residues [nucleotide binding]
362242010704	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
362242010705	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
362242010706	S-adenosylmethionine binding site [chemical binding]; other site
362242010707	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
362242010708	PE family; Region: PE; pfam00934
362242010709	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844
362242010710	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
362242010711	ligand binding site; other site
362242010712	oligomer interface; other site
362242010713	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
362242010714	dimer interface [polypeptide binding]; other site
362242010715	N-terminal domain interface [polypeptide binding]; other site
362242010716	sulfate 1 binding site; other site
362242010717	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242010718	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242010719	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242010720	Transposase, Mutator family; Region: Transposase_mut; pfam00872
362242010721	MULE transposase domain; Region: MULE; pfam10551
362242010722	Uncharacterized conserved protein [Function unknown]; Region: COG2128
362242010723	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
362242010724	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
362242010725	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
362242010726	non-specific DNA binding site [nucleotide binding]; other site
362242010727	salt bridge; other site
362242010728	sequence-specific DNA binding site [nucleotide binding]; other site
362242010729	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
362242010730	Domain of unknown function (DUF955); Region: DUF955; pfam06114
362242010731	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
362242010732	Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884
362242010733	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
362242010734	active site 2 [active]
362242010735	active site 1 [active]
362242010736	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
362242010737	active site 2 [active]
362242010738	isocitrate lyase; Provisional; Region: PRK15063
362242010739	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
362242010740	tetramer interface [polypeptide binding]; other site
362242010741	active site
362242010742	Mg2+/Mn2+ binding site [ion binding]; other site
362242010743	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819
362242010744	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
362242010745	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
362242010746	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
362242010747	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
362242010748	S-adenosylmethionine binding site [chemical binding]; other site
362242010749	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
362242010750	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
362242010751	S-adenosylmethionine binding site [chemical binding]; other site
362242010752	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
362242010753	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
362242010754	Predicted membrane protein [Function unknown]; Region: COG2733
362242010755	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
362242010756	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
362242010757	non-specific DNA binding site [nucleotide binding]; other site
362242010758	salt bridge; other site
362242010759	sequence-specific DNA binding site [nucleotide binding]; other site
362242010760	Protein of unknown function (DUF2516); Region: DUF2516; pfam10724
362242010761	Protein of unknown function (DUF2599); Region: DUF2599; pfam10783
362242010762	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
362242010763	intersubunit interface [polypeptide binding]; other site
362242010764	active site
362242010765	catalytic residue [active]
362242010766	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
362242010767	Predicted amidohydrolase [General function prediction only]; Region: COG0388
362242010768	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581
362242010769	putative active site [active]
362242010770	catalytic triad [active]
362242010771	putative dimer interface [polypeptide binding]; other site
362242010774	Protein of unknown function (DUF2505); Region: DUF2505; pfam10698
362242010775	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903
362242010776	FAD binding domain; Region: FAD_binding_4; pfam01565
362242010777	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
362242010778	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431
362242010779	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
362242010780	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432
362242010781	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
362242010782	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
362242010783	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
362242010784	NAD(P) binding site [chemical binding]; other site
362242010785	active site
362242010786	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
362242010787	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
362242010788	D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449
362242010789	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
362242010790	putative ADP-binding pocket [chemical binding]; other site
362242010791	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
362242010792	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
362242010793	catalytic core [active]
362242010794	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
362242010795	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
362242010796	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
362242010797	dimer interface [polypeptide binding]; other site
362242010798	phosphorylation site [posttranslational modification]
362242010799	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
362242010800	ATP binding site [chemical binding]; other site
362242010801	Mg2+ binding site [ion binding]; other site
362242010802	G-X-G motif; other site
362242010803	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
362242010804	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
362242010805	active site
362242010806	phosphorylation site [posttranslational modification]
362242010807	intermolecular recognition site; other site
362242010808	dimerization interface [polypeptide binding]; other site
362242010809	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
362242010810	DNA binding site [nucleotide binding]
362242010811	Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618
362242010812	GMC oxidoreductase; Region: GMC_oxred_N; pfam00732
362242010813	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
362242010814	Transcriptional regulators [Transcription]; Region: FadR; COG2186
362242010815	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
362242010816	DNA-binding site [nucleotide binding]; DNA binding site
362242010817	FCD domain; Region: FCD; cl11656
362242010818	exopolyphosphatase; Region: exo_poly_only; TIGR03706
362242010819	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
362242010820	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
362242010821	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
362242010822	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
362242010823	Diacylglycerol kinase catalytic domain (presumed); Region: DAGKc; smart00046
362242010824	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
362242010825	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
362242010826	DNA binding domain, excisionase family; Region: excise; TIGR01764
362242010827	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
362242010828	UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240
362242010829	putative NAD(P) binding site [chemical binding]; other site
362242010830	active site
362242010831	putative substrate binding site [chemical binding]; other site
362242010832	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
362242010833	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
362242010834	putative acyl-acceptor binding pocket; other site
362242010835	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
362242010836	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
362242010837	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
362242010838	S-adenosylmethionine binding site [chemical binding]; other site
362242010839	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
362242010840	active site
362242010841	catalytic site [active]
362242010842	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
362242010843	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
362242010844	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
362242010845	active site
362242010846	motif I; other site
362242010847	motif II; other site
362242010848	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
362242010849	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
362242010850	catalytic loop [active]
362242010851	iron binding site [ion binding]; other site
362242010852	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
362242010853	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
362242010854	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
362242010855	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
362242010856	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
362242010857	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
362242010858	PE family; Region: PE; pfam00934
362242010861	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242010862	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242010863	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242010864	Transposase, Mutator family; Region: Transposase_mut; pfam00872
362242010865	MULE transposase domain; Region: MULE; pfam10551
362242010866	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242010867	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242010868	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242010869	Transposase, Mutator family; Region: Transposase_mut; pfam00872
362242010870	MULE transposase domain; Region: MULE; pfam10551
362242010871	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242010872	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242010873	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242010874	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242010875	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242010876	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242010877	YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575
362242010878	Protein of unknown function (DUF2580); Region: DUF2580; pfam10824
362242010879	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
362242010880	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242010881	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242010882	Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768
362242010883	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
362242010884	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
362242010885	tRNA; other site
362242010886	putative tRNA binding site [nucleotide binding]; other site
362242010887	putative NADP binding site [chemical binding]; other site
362242010888	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
362242010889	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
362242010890	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
362242010891	domain interfaces; other site
362242010892	active site
362242010893	S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815
362242010894	active site
362242010895	homodimer interface [polypeptide binding]; other site
362242010896	SAM binding site [chemical binding]; other site
362242010897	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
362242010898	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
362242010899	active site
362242010900	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
362242010901	dimer interface [polypeptide binding]; other site
362242010902	active site
362242010903	Schiff base residues; other site
362242010904	Transposase, Mutator family; Region: Transposase_mut; pfam00872
362242010905	MULE transposase domain; Region: MULE; pfam10551
362242010906	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242010907	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242010908	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242010909	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242010910	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242010911	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242010912	Transposase, Mutator family; Region: Transposase_mut; pfam00872
362242010913	MULE transposase domain; Region: MULE; pfam10551
362242010914	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242010915	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242010916	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242010917	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
362242010918	dimerization interface [polypeptide binding]; other site
362242010919	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
362242010920	cyclase homology domain; Region: CHD; cd07302
362242010921	nucleotidyl binding site; other site
362242010922	metal binding site [ion binding]; metal-binding site
362242010923	dimer interface [polypeptide binding]; other site
362242010924	PE family; Region: PE; pfam00934
362242010925	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
362242010926	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
362242010927	PPE family; Region: PPE; pfam00823
362242010928	WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930
362242010929	Proteins of 100 residues with WXG; Region: WXG100; pfam06013
362242010930	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
362242010931	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
362242010932	active site
362242010933	phosphorylation site [posttranslational modification]
362242010934	intermolecular recognition site; other site
362242010935	dimerization interface [polypeptide binding]; other site
362242010936	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
362242010937	DNA binding site [nucleotide binding]
362242010938	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
362242010939	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
362242010940	dimer interface [polypeptide binding]; other site
362242010941	phosphorylation site [posttranslational modification]
362242010942	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
362242010943	ATP binding site [chemical binding]; other site
362242010944	Mg2+ binding site [ion binding]; other site
362242010945	G-X-G motif; other site
362242010946	Hydantoin racemase [Amino acid transport and metabolism]; Region: COG4126
362242010947	exopolyphosphatase; Region: exo_poly_only; TIGR03706
362242010948	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
362242010949	Uncharacterized conserved protein [Function unknown]; Region: COG1507
362242010950	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
362242010951	Septum formation initiator; Region: DivIC; pfam04977
362242010952	enolase; Provisional; Region: eno; PRK00077
362242010953	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
362242010954	dimer interface [polypeptide binding]; other site
362242010955	metal binding site [ion binding]; metal-binding site
362242010956	substrate binding pocket [chemical binding]; other site
362242010957	Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951
362242010958	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
362242010959	N-acetyl-D-glucosamine binding site [chemical binding]; other site
362242010960	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334
362242010961	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
362242010962	homodimer interface [polypeptide binding]; other site
362242010963	metal binding site [ion binding]; metal-binding site
362242010964	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
362242010965	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
362242010966	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
362242010967	ATP binding site [chemical binding]; other site
362242010968	putative Mg++ binding site [ion binding]; other site
362242010969	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
362242010970	nucleotide binding region [chemical binding]; other site
362242010971	ATP-binding site [chemical binding]; other site
362242010972	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
362242010973	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
362242010974	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
362242010975	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352
362242010976	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
362242010977	Substrate binding site; other site
362242010978	Mg++ binding site; other site
362242010979	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
362242010980	active site
362242010981	substrate binding site [chemical binding]; other site
362242010982	CoA binding site [chemical binding]; other site
362242010983	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
362242010984	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092
362242010985	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
362242010986	active site
362242010987	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
362242010988	ArsC family; Region: ArsC; pfam03960
362242010989	catalytic residues [active]
362242010990	Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738
362242010991	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242010992	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242010993	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242010994	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
362242010995	ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731
362242010996	5S rRNA interface [nucleotide binding]; other site
362242010997	CTC domain interface [polypeptide binding]; other site
362242010998	L16 interface [polypeptide binding]; other site
362242010999	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
362242011000	putative active site [active]
362242011001	catalytic residue [active]
362242011002	Domain of unknown function DUF302; Region: DUF302; pfam03625
362242011003	Domain of unknown function DUF302; Region: DUF302; pfam03625
362242011006	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768
362242011007	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
362242011008	acyl-activating enzyme (AAE) consensus motif; other site
362242011009	active site
362242011010	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188
362242011011	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
362242011012	Ribosomal RNA adenine dimethylase; Region: RrnaAD; pfam00398
362242011013	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
362242011014	S-adenosylmethionine binding site [chemical binding]; other site
362242011015	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583
362242011016	Domain of unknown function (DUF348); Region: DUF348; pfam03990
362242011017	Domain of unknown function (DUF348); Region: DUF348; pfam03990
362242011018	Domain of unknown function (DUF348); Region: DUF348; pfam03990
362242011019	G5 domain; Region: G5; pfam07501
362242011020	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
362242011021	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
362242011022	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
362242011023	active site
362242011024	methionyl-tRNA synthetase; Reviewed; Region: PRK11893
362242011025	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
362242011026	active site
362242011027	HIGH motif; other site
362242011028	KMSKS motif; other site
362242011029	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
362242011030	tRNA binding surface [nucleotide binding]; other site
362242011031	anticodon binding site; other site
362242011033	colanic acid biosynthesis acetyltransferase WcaB; Region: WcaB; TIGR04016
362242011034	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
362242011035	trimer interface [polypeptide binding]; other site
362242011036	active site
362242011037	substrate binding site [chemical binding]; other site
362242011038	CoA binding site [chemical binding]; other site
362242011039	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
362242011040	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
362242011041	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
362242011042	aminodeoxychorismate synthase component I; Provisional; Region: PRK05877
362242011043	chorismate binding enzyme; Region: Chorismate_bind; cl10555
362242011044	Predicted methyltransferases [General function prediction only]; Region: COG0313
362242011045	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
362242011046	putative SAM binding site [chemical binding]; other site
362242011047	putative homodimer interface [polypeptide binding]; other site
362242011048	Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928
362242011049	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
362242011050	arginine deiminase; Provisional; Region: PRK01388
362242011051	Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145
362242011052	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
362242011053	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
362242011054	ligand binding site [chemical binding]; other site
362242011055	flexible hinge region; other site
362242011056	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
362242011057	Methyltransferase domain; Region: Methyltransf_31; pfam13847
362242011058	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
362242011059	S-adenosylmethionine binding site [chemical binding]; other site
362242011060	Protein of unknown function (DUF4239); Region: DUF4239; pfam14023
362242011061	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
362242011062	PPE family; Region: PPE; pfam00823
362242011063	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
362242011064	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
362242011065	Bacterial sugar transferase; Region: Bac_transf; pfam02397
362242011066	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
362242011067	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
362242011068	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
362242011069	active site
362242011070	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
362242011071	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
362242011072	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
362242011073	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
362242011074	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
362242011075	Methyltransferase domain; Region: Methyltransf_23; pfam13489
362242011076	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
362242011077	S-adenosylmethionine binding site [chemical binding]; other site
362242011078	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
362242011079	Methyltransferase domain; Region: Methyltransf_23; pfam13489
362242011080	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
362242011081	S-adenosylmethionine binding site [chemical binding]; other site
362242011082	Methyltransferase domain; Region: Methyltransf_11; pfam08241
362242011083	Predicted amidohydrolase [General function prediction only]; Region: COG0388
362242011084	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197
362242011085	active site
362242011086	catalytic triad [active]
362242011087	dimer interface [polypeptide binding]; other site
362242011088	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
362242011089	S-adenosylmethionine binding site [chemical binding]; other site
362242011090	O-Antigen ligase; Region: Wzy_C; pfam04932
362242011091	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
362242011092	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
362242011093	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
362242011094	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
362242011095	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
362242011096	dimer interface [polypeptide binding]; other site
362242011097	putative functional site; other site
362242011098	putative MPT binding site; other site
362242011099	UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210
362242011100	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
362242011101	active site
362242011102	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
362242011103	5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212
362242011104	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2331
362242011105	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
362242011106	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
362242011107	Large-conductance mechanosensitive channel, MscL; Region: MscL; pfam01741
362242011108	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
362242011109	MPT binding site; other site
362242011110	trimer interface [polypeptide binding]; other site
362242011111	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
362242011112	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
362242011113	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
362242011114	protein binding site [polypeptide binding]; other site
362242011115	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
362242011116	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
362242011117	dimerization interface [polypeptide binding]; other site
362242011118	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
362242011119	dimer interface [polypeptide binding]; other site
362242011120	phosphorylation site [posttranslational modification]
362242011121	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
362242011122	ATP binding site [chemical binding]; other site
362242011123	Mg2+ binding site [ion binding]; other site
362242011124	G-X-G motif; other site
362242011125	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
362242011126	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
362242011127	active site
362242011128	phosphorylation site [posttranslational modification]
362242011129	intermolecular recognition site; other site
362242011130	dimerization interface [polypeptide binding]; other site
362242011131	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
362242011132	DNA binding site [nucleotide binding]
362242011133	Protein of unknown function (DUF1446); Region: DUF1446; pfam07287
362242011134	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
362242011135	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
362242011136	active site
362242011137	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
362242011138	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
362242011139	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
362242011140	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
362242011141	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
362242011142	ATP-grasp domain; Region: ATP-grasp_4; cl17255
362242011143	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
362242011144	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
362242011145	carboxyltransferase (CT) interaction site; other site
362242011146	biotinylation site [posttranslational modification]; other site
362242011147	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
362242011148	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
362242011149	active site
362242011150	enoyl-CoA hydratase; Provisional; Region: PRK07827
362242011151	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
362242011152	substrate binding site [chemical binding]; other site
362242011153	oxyanion hole (OAH) forming residues; other site
362242011154	trimer interface [polypeptide binding]; other site
362242011156	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
362242011157	Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867
362242011158	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
362242011159	metal ion-dependent adhesion site (MIDAS); other site
362242011160	Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239
362242011161	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
362242011162	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
362242011163	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
362242011164	purine monophosphate binding site [chemical binding]; other site
362242011165	dimer interface [polypeptide binding]; other site
362242011166	putative catalytic residues [active]
362242011167	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
362242011168	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
362242011169	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
362242011170	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
362242011171	active site
362242011172	substrate binding site [chemical binding]; other site
362242011173	cosubstrate binding site; other site
362242011174	catalytic site [active]
362242011175	acetyl-CoA acetyltransferase; Validated; Region: PRK08257
362242011176	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
362242011177	active site
362242011179	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
362242011180	CoA binding domain; Region: CoA_binding; smart00881
362242011181	CoA-ligase; Region: Ligase_CoA; pfam00549
362242011182	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
362242011183	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
362242011184	CoA-ligase; Region: Ligase_CoA; pfam00549
362242011185	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
362242011186	Peptidase family M23; Region: Peptidase_M23; pfam01551
362242011187	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
362242011188	Part of AAA domain; Region: AAA_19; pfam13245
362242011189	Family description; Region: UvrD_C_2; pfam13538
362242011190	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242011191	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242011192	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242011193	Transposase, Mutator family; Region: Transposase_mut; pfam00872
362242011194	MULE transposase domain; Region: MULE; pfam10551
362242011195	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242011196	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242011197	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242011198	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
362242011199	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
362242011200	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
362242011201	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
362242011202	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
362242011203	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
362242011204	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
362242011205	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
362242011206	ligand binding site [chemical binding]; other site
362242011207	homodimer interface [polypeptide binding]; other site
362242011208	NAD(P) binding site [chemical binding]; other site
362242011209	trimer interface B [polypeptide binding]; other site
362242011210	trimer interface A [polypeptide binding]; other site
362242011211	SnoaL-like domain; Region: SnoaL_2; pfam12680
362242011212	Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365
362242011213	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
362242011214	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
362242011215	Protein of unknown function (DUF3060); Region: DUF3060; pfam11259
362242011216	glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218
362242011217	active site
362242011218	catalytic residues [active]
362242011219	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242011220	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242011221	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242011222	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242011223	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242011224	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242011225	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242011226	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
362242011227	Catalytic domain of Protein Kinases; Region: PKc; cd00180
362242011228	active site
362242011229	ATP binding site [chemical binding]; other site
362242011230	substrate binding site [chemical binding]; other site
362242011231	activation loop (A-loop); other site
362242011232	Predicted ATPase [General function prediction only]; Region: COG3903
362242011233	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
362242011234	Catalytic domain of Protein Kinases; Region: PKc; cd00180
362242011235	active site
362242011236	ATP binding site [chemical binding]; other site
362242011237	substrate binding site [chemical binding]; other site
362242011238	activation loop (A-loop); other site
362242011239	Predicted ATPase [General function prediction only]; Region: COG3903
362242011240	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
362242011241	FMN binding site [chemical binding]; other site
362242011242	dimer interface [polypeptide binding]; other site
362242011243	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
362242011244	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
362242011245	NAD(P) binding site [chemical binding]; other site
362242011246	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
362242011247	(3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353
362242011248	homodimer interface [polypeptide binding]; other site
362242011249	NAD binding site [chemical binding]; other site
362242011250	active site
362242011251	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
362242011252	ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087
362242011253	NAD(P) binding site [chemical binding]; other site
362242011254	catalytic residues [active]
362242011255	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
362242011256	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
362242011257	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
362242011258	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
362242011259	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
362242011260	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
362242011261	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
362242011262	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
362242011263	Pirin-related protein [General function prediction only]; Region: COG1741
362242011264	Pirin; Region: Pirin; pfam02678
362242011265	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
362242011266	Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631
362242011267	Domain of unknown function (DUF427); Region: DUF427; cl00998
362242011268	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
362242011269	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
362242011270	NAD(P) binding site [chemical binding]; other site
362242011271	active site
362242011272	SnoaL-like domain; Region: SnoaL_2; pfam12680
362242011273	methionine sulfoxide reductase A; Provisional; Region: PRK14054
362242011274	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
362242011275	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
362242011276	Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585
362242011277	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
362242011278	6-hydroxycyclohex-1-ene-1-carboxyl-CoA dehydrogenase, N-benzyl-3-pyrrolidinol dehydrogenase, and other MDR family members; Region: hydroxyacyl_CoA_DH; cd08254
362242011279	putative NAD(P) binding site [chemical binding]; other site
362242011280	catalytic Zn binding site [ion binding]; other site
362242011281	structural Zn binding site [ion binding]; other site
362242011282	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
362242011283	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
362242011284	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
362242011285	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
362242011286	probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559
362242011287	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
362242011288	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
362242011289	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
362242011290	hydrophobic ligand binding site; other site
362242011291	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
362242011292	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
362242011293	putative di-iron ligands [ion binding]; other site
362242011294	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216
362242011295	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
362242011296	FAD binding pocket [chemical binding]; other site
362242011297	FAD binding motif [chemical binding]; other site
362242011298	phosphate binding motif [ion binding]; other site
362242011299	beta-alpha-beta structure motif; other site
362242011300	NAD binding pocket [chemical binding]; other site
362242011301	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
362242011302	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
362242011303	catalytic loop [active]
362242011304	iron binding site [ion binding]; other site
362242011305	DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202
362242011306	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
362242011307	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
362242011308	Coenzyme A binding pocket [chemical binding]; other site
362242011309	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
362242011310	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
362242011311	active site
362242011312	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
362242011313	putative active site [active]
362242011314	putative catalytic site [active]
362242011315	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
362242011316	active site
362242011317	metal binding site [ion binding]; metal-binding site
362242011318	homotetramer interface [polypeptide binding]; other site
362242011319	Putative esterase; Region: Esterase; pfam00756
362242011320	trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457
362242011321	Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281
362242011322	trehalose synthase; Region: treS_nterm; TIGR02456
362242011323	Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
362242011324	active site
362242011325	catalytic site [active]
362242011326	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
362242011327	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
362242011328	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
362242011329	protein binding site [polypeptide binding]; other site
362242011330	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531
362242011331	PPOX class probable F420-dependent enzyme, Rv0121 family; Region: Rv0121_F420; TIGR03668
362242011332	acyl-CoA synthetase; Validated; Region: PRK05852
362242011333	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
362242011334	Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; Region: FACL_fum10p_like; cd05926
362242011335	acyl-activating enzyme (AAE) consensus motif; other site
362242011336	acyl-activating enzyme (AAE) consensus motif; other site
362242011337	putative AMP binding site [chemical binding]; other site
362242011338	putative active site [active]
362242011339	putative CoA binding site [chemical binding]; other site
362242011340	putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259
362242011341	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
362242011342	PYR/PP interface [polypeptide binding]; other site
362242011343	dimer interface [polypeptide binding]; other site
362242011344	TPP binding site [chemical binding]; other site
362242011345	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
362242011346	Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004
362242011347	TPP-binding site; other site
362242011348	dimer interface [polypeptide binding]; other site
362242011349	Transcriptional regulator [Transcription]; Region: LysR; COG0583
362242011350	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
362242011351	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
362242011352	dimerization interface [polypeptide binding]; other site
362242011353	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431
362242011354	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
362242011355	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
362242011356	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
362242011357	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
362242011358	Methyltransferase domain; Region: Methyltransf_24; pfam13578
362242011359	S-adenosylmethionine binding site [chemical binding]; other site
362242011360	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
362242011361	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
362242011362	active site
362242011363	catalytic triad [active]
362242011364	oxyanion hole [active]
362242011365	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
362242011366	CoA-transferase family III; Region: CoA_transf_3; pfam02515
362242011367	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
362242011368	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
362242011369	NAD(P) binding site [chemical binding]; other site
362242011370	active site
362242011371	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
362242011372	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
362242011373	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
362242011374	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
362242011375	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
362242011376	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
362242011377	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
362242011378	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
362242011379	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
362242011380	DNA-binding site [nucleotide binding]; DNA binding site
362242011381	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
362242011382	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
362242011383	classical (c) SDRs; Region: SDR_c; cd05233
362242011384	NAD(P) binding site [chemical binding]; other site
362242011385	active site
362242011386	Rhomboid family; Region: Rhomboid; pfam01694
362242011387	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242011388	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242011389	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242011390	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
362242011391	ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494
362242011392	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
362242011393	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
362242011394	motif II; other site
362242011395	acyl-CoA synthetase; Provisional; Region: PRK13383
362242011396	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
362242011397	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
362242011398	AMP binding site [chemical binding]; other site
362242011399	active site
362242011400	acyl-activating enzyme (AAE) consensus motif; other site
362242011401	CoA binding site [chemical binding]; other site
362242011402	short chain dehydrogenase; Provisional; Region: PRK07454
362242011403	classical (c) SDRs; Region: SDR_c; cd05233
362242011404	NAD(P) binding site [chemical binding]; other site
362242011405	active site
362242011406	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
362242011407	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
362242011408	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
362242011409	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
362242011410	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
362242011411	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
362242011412	30S ribosomal protein S18; Provisional; Region: PRK13401
362242011413	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995
362242011414	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
362242011415	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
362242011416	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
362242011417	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
362242011418	cyclase homology domain; Region: CHD; cd07302
362242011419	nucleotidyl binding site; other site
362242011420	metal binding site [ion binding]; metal-binding site
362242011421	dimer interface [polypeptide binding]; other site
362242011422	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242011423	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242011424	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242011425	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
362242011426	classical (c) SDRs; Region: SDR_c; cd05233
362242011427	NAD(P) binding site [chemical binding]; other site
362242011428	active site
362242011429	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
362242011430	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
362242011431	metal-binding site [ion binding]
362242011432	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
362242011433	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
362242011434	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
362242011435	metal-binding site [ion binding]
362242011436	Predicted membrane protein [Function unknown]; Region: COG3336
362242011437	RNA polymerase sigma factor SigY; Reviewed; Region: PRK09638
362242011438	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
362242011439	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
362242011440	DNA binding residues [nucleotide binding]
362242011441	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
362242011442	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
362242011443	metal-binding site [ion binding]
362242011444	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
362242011445	Soluble P-type ATPase [General function prediction only]; Region: COG4087
362242011446	Predicted integral membrane protein [Function unknown]; Region: COG5660
362242011447	Putative zinc-finger; Region: zf-HC2; pfam13490
362242011448	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
362242011449	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
362242011450	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
362242011451	PPE family; Region: PPE; pfam00823
362242011452	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
362242011453	Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668
362242011454	FcoT-like thioesterase domain; Region: FcoT; pfam10862
362242011455	acyl-CoA synthetase; Validated; Region: PRK05857
362242011456	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
362242011457	Adenylate forming domain, Class I; Region: AFD_class_I; cd04433
362242011458	acyl-activating enzyme (AAE) consensus motif; other site
362242011459	acyl-activating enzyme (AAE) consensus motif; other site
362242011460	AMP binding site [chemical binding]; other site
362242011461	active site
362242011462	CoA binding site [chemical binding]; other site
362242011463	AMP-binding enzyme; Region: AMP-binding; pfam00501
362242011464	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
362242011465	acyl-activating enzyme (AAE) consensus motif; other site
362242011466	AMP binding site [chemical binding]; other site
362242011467	active site
362242011468	CoA binding site [chemical binding]; other site
362242011469	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
362242011470	NAD(P) binding site [chemical binding]; other site
362242011471	active site
362242011472	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
362242011473	classical (c) SDRs; Region: SDR_c; cd05233
362242011474	NAD(P) binding site [chemical binding]; other site
362242011475	active site
362242011476	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825
362242011477	putative hydrophobic ligand binding site [chemical binding]; other site
362242011478	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
362242011479	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
362242011480	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
362242011481	2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase; Region: dhbA_paeA; TIGR04316
362242011482	NAD(P) binding site [chemical binding]; other site
362242011483	active site
362242011484	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
362242011485	CoenzymeA binding site [chemical binding]; other site
362242011486	subunit interaction site [polypeptide binding]; other site
362242011487	PHB binding site; other site
362242011488	Predicted membrane protein [Function unknown]; Region: COG3305
362242011489	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
362242011490	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
362242011491	substrate binding site [chemical binding]; other site
362242011492	oxyanion hole (OAH) forming residues; other site
362242011493	trimer interface [polypeptide binding]; other site
362242011494	Methyltransferase domain; Region: Methyltransf_23; pfam13489
362242011495	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
362242011496	S-adenosylmethionine binding site [chemical binding]; other site
362242011497	short chain dehydrogenase; Provisional; Region: PRK06940
362242011498	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
362242011499	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
362242011500	active site
362242011501	oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989
362242011502	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
362242011503	NAD binding site [chemical binding]; other site
362242011504	catalytic Zn binding site [ion binding]; other site
362242011505	substrate binding site [chemical binding]; other site
362242011506	structural Zn binding site [ion binding]; other site
362242011507	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
362242011508	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
362242011509	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
362242011510	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
362242011511	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
362242011512	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
362242011513	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
362242011514	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
362242011515	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
362242011516	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
362242011517	hydrophobic ligand binding site; other site
362242011518	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
362242011519	metal-binding site [ion binding]
362242011520	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
362242011521	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
362242011522	iron-sulfur cluster [ion binding]; other site
362242011523	[2Fe-2S] cluster binding site [ion binding]; other site
362242011524	C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_3; cd08887
362242011525	putative alpha subunit interface [polypeptide binding]; other site
362242011526	putative active site [active]
362242011527	putative substrate binding site [chemical binding]; other site
362242011528	Fe binding site [ion binding]; other site
362242011529	PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223
362242011530	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
362242011531	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
362242011532	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
362242011533	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
362242011534	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
362242011535	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
362242011536	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
362242011537	Protein of unknown function (DUF1214); Region: DUF1214; cl08447
362242011538	Transposase, Mutator family; Region: Transposase_mut; pfam00872
362242011539	MULE transposase domain; Region: MULE; pfam10551
362242011540	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242011541	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242011542	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242011543	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
362242011544	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
362242011545	hypothetical protein; Validated; Region: PRK07121
362242011546	Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002
362242011547	Predicted oxidoreductase [General function prediction only]; Region: COG3573
362242011548	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
362242011549	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
362242011550	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
362242011551	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
362242011552	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
362242011553	dimer interface [polypeptide binding]; other site
362242011554	active site
362242011555	glycine-pyridoxal phosphate binding site [chemical binding]; other site
362242011556	folate binding site [chemical binding]; other site
362242011557	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
362242011558	lipoyl attachment site [posttranslational modification]; other site
362242011559	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242011560	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242011561	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242011562	PE family; Region: PE; pfam00934
362242011564	Proteins of 100 residues with WXG; Region: WXG100; pfam06013
362242011565	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242011566	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242011567	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
362242011568	mce related protein; Region: MCE; pfam02470
362242011569	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
362242011570	mce related protein; Region: MCE; pfam02470
362242011571	mce related protein; Region: MCE; pfam02470
362242011572	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
362242011573	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
362242011574	mce related protein; Region: MCE; pfam02470
362242011575	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
362242011576	mce related protein; Region: MCE; pfam02470
362242011577	mce related protein; Region: MCE; pfam02470
362242011578	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
362242011579	Permease; Region: Permease; pfam02405
362242011580	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
362242011581	Permease; Region: Permease; pfam02405
362242011582	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768
362242011583	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
362242011584	acyl-activating enzyme (AAE) consensus motif; other site
362242011585	active site
362242011586	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
362242011587	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
362242011588	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
362242011589	Walker A/P-loop; other site
362242011590	ATP binding site [chemical binding]; other site
362242011591	Q-loop/lid; other site
362242011592	ABC transporter signature motif; other site
362242011593	Walker B; other site
362242011594	D-loop; other site
362242011595	H-loop/switch region; other site
362242011596	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
362242011597	hydrophobic ligand binding site; other site
362242011598	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
362242011599	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
362242011600	catalytic residue [active]
362242011601	diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06938
362242011602	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
362242011603	inhibitor-cofactor binding pocket; inhibition site
362242011604	pyridoxal 5'-phosphate binding site [chemical binding]; other site
362242011605	catalytic residue [active]
362242011606	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
362242011607	uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228
362242011608	putative NADP binding site [chemical binding]; other site
362242011609	putative substrate binding site [chemical binding]; other site
362242011610	active site
362242011611	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
362242011612	Coenzyme A binding pocket [chemical binding]; other site
362242011613	Mannan-binding protein; Region: MVL; pfam12151
362242011614	Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838
362242011615	Monomeric isocitrate dehydrogenase; Region: IDH; pfam03971
362242011616	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
362242011617	cyclase homology domain; Region: CHD; cd07302
362242011618	nucleotidyl binding site; other site
362242011619	metal binding site [ion binding]; metal-binding site
362242011620	dimer interface [polypeptide binding]; other site
362242011621	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
362242011622	putative active site [active]
362242011623	putative substrate binding site [chemical binding]; other site
362242011624	ATP binding site [chemical binding]; other site
362242011625	probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559
362242011626	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
362242011627	SnoaL-like domain; Region: SnoaL_2; pfam12680
362242011628	Predicted transcriptional regulators [Transcription]; Region: COG1695
362242011629	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
362242011630	Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400
362242011631	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
362242011632	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
362242011633	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
362242011634	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
362242011635	active site
362242011636	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
362242011637	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
362242011638	homodimer interface [polypeptide binding]; other site
362242011639	active site
362242011640	TDP-binding site; other site
362242011641	acceptor substrate-binding pocket; other site
362242011642	CAAX protease self-immunity; Region: Abi; pfam02517
362242011643	Predicted ATPase [General function prediction only]; Region: COG4637
362242011644	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
362242011645	Walker A/P-loop; other site
362242011646	ATP binding site [chemical binding]; other site
362242011647	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
362242011648	ABC transporter signature motif; other site
362242011649	Walker B; other site
362242011650	D-loop; other site
362242011651	H-loop/switch region; other site
362242011652	Transcriptional regulators [Transcription]; Region: MarR; COG1846
362242011653	MarR family; Region: MarR; pfam01047
362242011654	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
362242011655	DUF35 OB-fold domain; Region: DUF35; pfam01796
362242011656	acetyl-CoA acetyltransferase; Validated; Region: PRK06157
362242011657	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
362242011658	active site
362242011659	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
362242011660	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
362242011661	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
362242011662	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
362242011663	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
362242011664	active site
362242011665	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
362242011666	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
362242011667	active site
362242011668	Amidohydrolase; Region: Amidohydro_2; pfam04909
362242011669	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
362242011670	Major Facilitator Superfamily; Region: MFS_1; pfam07690
362242011671	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
362242011672	putative substrate translocation pore; other site
362242011673	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
362242011674	putative active site [active]
362242011675	putative CoA binding site [chemical binding]; other site
362242011676	nudix motif; other site
362242011677	metal binding site [ion binding]; metal-binding site
362242011678	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242011679	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242011680	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242011681	nucleoside diphosphate kinase regulator; Provisional; Region: PRK05892
362242011682	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
362242011683	Predicted membrane protein [Function unknown]; Region: COG2246
362242011684	GtrA-like protein; Region: GtrA; pfam04138
362242011685	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
362242011686	FAD binding domain; Region: FAD_binding_4; pfam01565
362242011687	D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030
362242011688	short chain dehydrogenase; Provisional; Region: PRK07904
362242011689	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
362242011690	NAD(P) binding site [chemical binding]; other site
362242011691	active site
362242011692	Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250
362242011693	Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249
362242011694	Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602
362242011695	Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602
362242011696	Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602
362242011697	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242011698	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242011699	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242011703	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
362242011704	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
362242011705	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
362242011706	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
362242011707	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
362242011708	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
362242011709	active site
362242011710	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
362242011711	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
362242011712	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
362242011713	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
362242011714	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769
362242011715	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
362242011716	acyl-activating enzyme (AAE) consensus motif; other site
362242011717	active site
362242011718	Cutinase; Region: Cutinase; pfam01083
362242011719	Predicted esterase [General function prediction only]; Region: COG0627
362242011720	Putative esterase; Region: Esterase; pfam00756
362242011721	phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324
362242011722	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
362242011723	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
362242011724	active site
362242011725	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
362242011726	UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562
362242011727	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
362242011728	UDP-galactopyranose mutase; Region: GLF; pfam03275
362242011729	Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479
362242011730	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
362242011731	amidase catalytic site [active]
362242011732	Zn binding residues [ion binding]; other site
362242011733	substrate binding site [chemical binding]; other site
362242011734	LGFP repeat; Region: LGFP; pfam08310
362242011735	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
362242011736	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
362242011737	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
362242011738	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
362242011739	putative acyl-acceptor binding pocket; other site
362242011740	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
362242011741	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
362242011742	putative acyl-acceptor binding pocket; other site
362242011743	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
362242011744	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
362242011745	putative acyl-acceptor binding pocket; other site
362242011746	Phosphotransferase enzyme family; Region: APH; pfam01636
362242011747	Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150
362242011748	active site
362242011749	ATP binding site [chemical binding]; other site
362242011750	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
362242011751	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
362242011752	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
362242011753	iron-sulfur cluster [ion binding]; other site
362242011754	[2Fe-2S] cluster binding site [ion binding]; other site
362242011755	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
362242011756	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
362242011757	Protein of unknown function (DUF2834); Region: DUF2834; pfam11196
362242011758	seryl-tRNA synthetase; Provisional; Region: PRK05431
362242011759	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
362242011760	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
362242011761	dimer interface [polypeptide binding]; other site
362242011762	active site
362242011763	motif 1; other site
362242011764	motif 2; other site
362242011765	motif 3; other site
362242011766	Septum formation; Region: Septum_form; pfam13845
362242011767	Septum formation; Region: Septum_form; pfam13845
362242011768	Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952
362242011769	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
362242011770	catalytic core [active]
362242011771	prephenate dehydratase; Provisional; Region: PRK11898
362242011772	Prephenate dehydratase; Region: PDT; pfam00800
362242011773	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
362242011774	putative L-Phe binding site [chemical binding]; other site
362242011775	Protein of unknown function (DUF2470); Region: DUF2470; pfam10615
362242011776	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816
362242011777	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
362242011778	Ferritin-like domain; Region: Ferritin; pfam00210
362242011779	ferroxidase diiron center [ion binding]; other site
362242011780	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582
362242011781	Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009
362242011782	putative active site [active]
362242011783	catalytic site [active]
362242011784	putative metal binding site [ion binding]; other site
362242011785	Domain of unknown function (DUF4328); Region: DUF4328; pfam14219
362242011786	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
362242011787	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
362242011788	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
362242011789	Predicted membrane protein [Function unknown]; Region: COG2119
362242011790	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
362242011791	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
362242011792	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
362242011793	ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372
362242011794	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
362242011795	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
362242011796	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
362242011797	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
362242011798	DNA polymerase IV; Validated; Region: PRK03858
362242011799	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
362242011800	active site
362242011801	DNA binding site [nucleotide binding]
362242011802	hypothetical protein; Provisional; Region: PRK07945
362242011803	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
362242011804	Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436
362242011805	active site
362242011806	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
362242011807	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
362242011808	Ligand Binding Site [chemical binding]; other site
362242011809	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
362242011810	Ligand Binding Site [chemical binding]; other site
362242011811	probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560
362242011812	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
362242011813	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
362242011814	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
362242011815	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
362242011816	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
362242011817	active site
362242011818	dimer interface [polypeptide binding]; other site
362242011819	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
362242011820	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
362242011821	active site
362242011822	FMN binding site [chemical binding]; other site
362242011823	substrate binding site [chemical binding]; other site
362242011824	3Fe-4S cluster binding site [ion binding]; other site
362242011825	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
362242011826	domain interface; other site
362242011827	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242011828	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242011829	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242011830	Transposase, Mutator family; Region: Transposase_mut; pfam00872
362242011831	MULE transposase domain; Region: MULE; pfam10551
362242011832	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242011833	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
362242011834	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
362242011835	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
362242011836	N-acetyl-D-glucosamine binding site [chemical binding]; other site
362242011837	catalytic residue [active]
362242011839	Proteins of 100 residues with WXG; Region: WXG100; pfam06013
362242011840	Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259
362242011841	Protein of unknown function (DUF2563); Region: DUF2563; pfam10817
362242011842	tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692
362242011843	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
362242011844	active site
362242011845	NTP binding site [chemical binding]; other site
362242011846	metal binding triad [ion binding]; metal-binding site
362242011847	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
362242011848	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
362242011849	Zn2+ binding site [ion binding]; other site
362242011850	Mg2+ binding site [ion binding]; other site
362242011851	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
362242011852	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
362242011853	active site
362242011854	Ap6A binding site [chemical binding]; other site
362242011855	nudix motif; other site
362242011856	metal binding site [ion binding]; metal-binding site
362242011857	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
362242011858	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
362242011859	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
362242011860	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
362242011861	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
362242011862	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
362242011863	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
362242011864	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
362242011865	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
362242011866	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
362242011867	catalytic residues [active]
362242011868	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
362242011869	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
362242011870	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
362242011871	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
362242011872	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
362242011873	active site
362242011874	metal binding site [ion binding]; metal-binding site
362242011875	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
362242011876	ParB-like nuclease domain; Region: ParB; smart00470
362242011877	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
362242011878	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
362242011879	P-loop; other site
362242011880	Magnesium ion binding site [ion binding]; other site
362242011881	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
362242011882	Magnesium ion binding site [ion binding]; other site
362242011883	rRNA small subunit methyltransferase G; Region: GidB; pfam02527
362242011884	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
362242011885	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
362242011886	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
362242011887	G-X-X-G motif; other site
362242011888	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
362242011889	RxxxH motif; other site
362242011890	putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449
362242011891	hypothetical protein; Validated; Region: PRK00041
362242011892	ribonuclease P; Reviewed; Region: rnpA; PRK00588
362242011893	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399